Tnc - SNV Details



 Gene Information 
Gene Name Tnc
Old Gene Names for Tnc C130033p17rik , Hxb , Ai528729 , Ten
Gene Description tenascin C [Source:MGI Symbol;Acc:MGI:101922]
MGI phenotype Mice homozygous for several different targeted mutations show variable behavioral and nervous system phenotypes such as abnormal circadian rhythm, anxiety behavior, novelty-induced activity, swimming, impaired synaptic plasticity, long term potentiation and serotonin and dopamine neurotransmission.
Uniprot Name
CCDS Name
Gene GO
basement membrane; extracellular matrix; prostate gland epithelium morphogenesis; signal transduction; cell adhesion; neuromuscular junction development; syndecan binding; peripheral nervous system axon regeneration; protein binding; mesenchymal-epithelial cell signaling involved in prostate gland development; response to wounding; extracellular region; interstitial matrix; receptor binding; extracellular space; positive regulation of cell proliferation; positive regulation of gene expression
Homolog in other species TNC
Omim http://omim.org/entry/187380
Immgen Expression
MEDIAN(HIGHER IN DC.LC.SK)
Gnf Expression
MEDIAN(HIGH IN RETINA, PITUITARY, DORSALROOTGANGLION, TRIGEMINAL, KIDNEY, LIVER, C2C12, UMBLICALCORD, NIH.3T3, OSTEOBLASTS, EPITH GROUP, IMM.G2, TRACHEA, PROSTATE, LUNG, BLADDER, UTERUS, OVARY, ADIPOSETISSUE, ADRENALGLAND)
Novel Yes

 Mutation Information 
Mutation Type Splice
Ensembl ID ENSMUSG00000028364
Chromosome 4
Coordinate 63,970,307     (Assembly: GRCm38)    
Ref Base T
Var Base C
Zygosity Heterozygous
Read Depth 30
Allele Frequency
T:R0.70
C:V0.30
Amino Acid Change Disrupted splicing
Splice Position 7
Sample ID IGL01661
Median Base Quality 38.5
Backgrounds C57BL/6NCrl
Source Australian Phenomics Facility (APF-G1)
Other variants in this mouse 22 Other Mutations

 Predictions 
Druggable Yes, View known drug interactions

 Availability Details 
Availability Progeny Cryopreserved , Cryopreserved