Tpp2 - SNV Details



 Gene Information 
Gene Name Tpp2
Gene Description tripeptidyl peptidase II [Source:MGI Symbol;Acc:MGI:102724]
MGI phenotype Engineered mutations of this gene result in decreased lifespan and symptoms of immunohematopoietic senescence.
Uniprot Name
CCDS Name
Gene GO
aminopeptidase activity; cytoplasm; peptide binding; nucleus; tripeptidyl-peptidase activity; proteolysis; serine-type endopeptidase activity
Homolog in other species TPP2
Omim http://omim.org/entry/190470
Immgen Expression
HIGH
Gnf Expression
HIGH
Novel Yes

 Mutation Information 
Mutation Type Non-synonymous
Ensembl ID ENSMUSG00000041763
Chromosome 1
Coordinate 43,954,653     (Assembly: GRCm38)    
Ref Base T
Codon Change Tac/Cac
Var Base C
Zygosity Heterozygous
Read Depth 59
Allele Frequency
T:R0.37
C:V0.63
Amino Acid Position 233
Amino Acid Change Y->H (Tyrosine -> Histidine)
Sample ID IGL01642
Median Base Quality 36
Backgrounds Balb/c:C57BL/6
Source Walter and Eliza Hall Institute (WEHI-G1)
Other variants in this mouse 61 Other Mutations

 Predictions 
Polyphen Score 0.88
Polyphen Prediction Possibly damaging
Sift Score 0.32
Sift Prediction tolerated
Druggable Yes, View known drug interactions

 Protein domains 
ENSMUSP00000085244:
Image provided by Ensembl

Full name Short name Interpro SeqRegionName Type Start End Description Search pathways
Peptidase S8/S53 domain Peptidase_S8/S53_dom IPR000209 ENSMUSP00000085244 Superfamily 12
510 Description available Search pathways
Peptidase S8/S53 domain Peptidase_S8/S53_dom IPR000209 ENSMUSP00000085244 Pfam 26
500 Description available Search pathways

 Availability Details 
Availability Cryopreserved