Tlk1 - SNV Details



 Gene Information 
Gene Name Tlk1
Old Gene Names for Tlk1 4930545j15rik
Gene Description tousled-like kinase 1 [Source:MGI Symbol;Acc:MGI:2441683]
Uniprot Name
CCDS Name
Gene GO
intracellular signal transduction; protein kinase activity; cell cycle; transferase activity
transferring phosphorus-containing groups; intracellular protein transport; nucleus; regulation of chromatin assembly or disassembly; chromatin modification; protein phosphorylation; response to DNA damage stimulus; protein tyrosine kinase activity; ATP binding; protein serine/threonine kinase activity
Homolog in other species TLK1
Immgen Expression
MEDIAN(LOW IN PROB.FRBC.FL, DC8+.TH, DC.LC.SK)
Gnf Expression
HIGH(LOWER IN FERTILIZED EGG, OOCYTE, PANCREAS, SPLEEN, BONE MARROW, THYROID)
Novel Yes

 Mutation Information 
Mutation Type Non-synonymous
Ensembl ID ENSMUSG00000041997
Chromosome 2
Coordinate 70,752,266     (Assembly: GRCm38)    
Ref Base T
Codon Change aAc/aGc
Var Base C
Zygosity Heterozygous
Read Depth 29
Allele Frequency
T:R0.34
C:V0.66
Amino Acid Position 173
Amino Acid Change N->S (Asparagine -> Serine)
Sample ID IGL01514
Median Base Quality 34
Backgrounds C57BL/6NCrl
Source Australian Phenomics Facility (APF-G1)
Other variants in this mouse 35 Other Mutations

 Predictions 
Polyphen Score 0
Polyphen Prediction Benign
Sift Score 0.52
Sift Prediction tolerated
Druggable Yes, View known drug interactions

 Availability Details 
Availability Progeny Cryopreserved