Id|IGL Id|Chromosome|Coordinate (Assembly version: GRCm38)|Amino Acid Change|Splice Position|Polyphen Score|Polyphen Prediction|SIFT Score|SIFT Prediction|MGI accession Id|Gene Name|Gene Description|Zygosity|Phenotype|Ref Base|Var Base|Read Depth|Median Base Quality|Snp Exon Type|Availability|Source
817025|IGL00430|19|43784202|S->N||0.39|Benign|0.08|tolerated|MGI:1352447|Abcc2|ATP-binding cassette, sub-family C (CFTR/MRP), member 2 [Source:MGI Symbol;Acc:MGI:1352447]|Heterozygous|Mice homozygous for disruptions in this gene have moderately enlarged livers, elevated plasma and urin bilirubin, and a reduced ability to clear various drugs and carcinogens from the blood.|G|A|140|33.0|Non-synonymous|Unprocessed|APF-G1
817026|IGL00430|12|101886147|I->V||0.05|Benign|0.21|tolerated|MGI:1924393|Trip11|thyroid hormone receptor interactor 11 [Source:MGI Symbol;Acc:MGI:1924393]|Heterozygous|Mice homozygous for a null allele exhibit neonatal lethality associated with small size, lung hypoplasia, omphalocele, and ventricular septal defects.|T|C|116|38.0|Non-synonymous|Unprocessed|APF-G1
817027|IGL00430|6|142101651|C->Stop|||N/A|||MGI:1351906|Slco1a6|solute carrier organic anion transporter family, member 1a6 [Source:MGI Symbol;Acc:MGI:1351906]|Heterozygous||A|T|100|38.0|Non-synonymous|Unprocessed|APF-G1
817028|IGL00430|4|127101949|C->Stop|||N/A|||MGI:106505|Zmym6|zinc finger, MYM-type 6 [Source:MGI Symbol;Acc:MGI:106505]|Heterozygous||T|A|89|39.0|Non-synonymous|Unprocessed|APF-G1
817029|IGL00430|13|63858319|V->F||0.05|Benign|0.18|tolerated|MGI:1923501|0610007p08rik|RIKEN cDNA 0610007P08 gene [Source:MGI Symbol;Acc:MGI:1923501]|Heterozygous||G|T|88|39.0|Non-synonymous|Unprocessed|APF-G1
817030|IGL00430|19|38725017|E->G||0.98|Probably damaging|0.01|deleterious|MGI:1921305|Plce1|phospholipase C, epsilon 1 [Source:MGI Symbol;Acc:MGI:1921305]|Heterozygous|Homozygous mutation of this gene results in a congenital semilunar valvulogenesis defect which causes regurgitation and stenosis, and decreased incidence of induced skin tumors. Another mutant exhibits decreased cardiac contraction and increased hypertrophy in response to chronic stress.|A|G|74|36.5|Non-synonymous|Unprocessed|APF-G1
817031|IGL00430|4|73771425|Q->Stop|||N/A|||MGI:2448565|Rasef|RAS and EF hand domain containing [Source:MGI Symbol;Acc:MGI:2448565]|Heterozygous||G|A|71|39.0|Non-synonymous|Unprocessed|APF-G1
817032|IGL00430|15|79719136|G->W||0.1|Benign|0.01|deleterious|MGI:109443|Gtpbp1|GTP binding protein 1 [Source:MGI Symbol;Acc:MGI:109443]|Heterozygous|Homozygous mice for a targeted null mutation were viable and fertile with no obvious morphological or behavioral defects.  In addition, no defects in macrophage function were observed.|G|T|66|33.0|Non-synonymous|Unprocessed|APF-G1
817033|IGL00430|17|43836384|T->A|||N/A|0.63|tolerated|MGI:1858219|Rcan2|regulator of calcineurin 2 [Source:MGI Symbol;Acc:MGI:1858219]|Heterozygous|Mice homozygous for a knock-out alle exhibit decreased body weight and resistance to diet-induced obesity, steatosis, glucose intolerance, and insulin sensitivity.|A|G|66|35.0|Non-synonymous|Unprocessed|APF-G1
817034|IGL00430|10|97681147|K->N||0.09|Benign|0.65|tolerated|MGI:107942|Epyc|epiphycan [Source:MGI Symbol;Acc:MGI:107942]|Heterozygous||A|T|62|38.0|Non-synonymous|Unprocessed|APF-G1
817035|IGL00430|18|37296463|Q->H|||Benign|0.31|tolerated|MGI:2136735|Pcdhb2|protocadherin beta 2 [Source:MGI Symbol;Acc:MGI:2136735]|Heterozygous||A|T|61|35.0|Non-synonymous|Unprocessed|APF-G1
817036|IGL00430|5|145993360|M->K||1.0|Probably damaging||deleterious|MGI:1930638|Cyp3a25|cytochrome P450, family 3, subfamily a, polypeptide 25 [Source:MGI Symbol;Acc:MGI:1930638]|Heterozygous||A|T|61|37.0|Non-synonymous|Unprocessed|APF-G1
817037|IGL00430|9|65182019|D->A||0.98|Probably damaging||deleterious|MGI:1202390|Igdcc3|immunoglobulin superfamily, DCC subclass, member 3 [Source:MGI Symbol;Acc:MGI:1202390]|Heterozygous|Homozygotes for a gene trap mutation exhibit reduced performance on the rotarod, suggesting impaired cerebellar function.|A|C|55|35.0|Non-synonymous|Unprocessed|APF-G1
817038|IGL00430|14|16422692|S->R|||Benign|0.32|tolerated|MGI:98791|Top2b|topoisomerase (DNA) II beta [Source:MGI Symbol;Acc:MGI:98791]|Heterozygous|Homozygous null mice exhibit abnormal innervation. Offspring die shortly after birth due to respiratory failure.|T|A|53|37.0|Non-synonymous|Unprocessed|APF-G1
817039|IGL00430|8|13413128|Y->Stop|||N/A|||MGI:1345146|Grk1|G protein-coupled receptor kinase 1 [Source:MGI Symbol;Acc:MGI:1345146]|Heterozygous|Analysis of homozygous null mice revealed abnormal photoresponses and light-induced apoptosis in rods. Mutant mice may serve as models of Oguchi disease and retinal degeneration.|C|A|52|36.0|Non-synonymous|Unprocessed|APF-G1
817040|IGL00430|14|119026429|L->Stop|||N/A|||MGI:1913685|Uggt2|UDP-glucose glycoprotein glucosyltransferase 2 [Source:MGI Symbol;Acc:MGI:1913685]|Heterozygous||A|T|45|37.0|Non-synonymous|Unprocessed|APF-G1
817041|IGL00430|2|59912795|A->S||0.31|Benign|0.13|tolerated|MGI:2442782|Baz2b|bromodomain adjacent to zinc finger domain, 2B [Source:MGI Symbol;Acc:MGI:2442782]|Heterozygous||C|A|45|38.0|Non-synonymous|Unprocessed|APF-G1
817042|IGL00430|14|55543944|A->V|||Benign|0.02|deleterious|MGI:1860456|Pck2|phosphoenolpyruvate carboxykinase 2 (mitochondrial) [Source:MGI Symbol;Acc:MGI:1860456]|Heterozygous||C|T|44|35.0|Non-synonymous|Unprocessed|APF-G1
817043|IGL00430|7|126447216|W->Stop|||N/A|||MGI:105058|Atp2a1|ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 [Source:MGI Symbol;Acc:MGI:105058]|Heterozygous|Homozygous mutation of this gene results in perinatal lethality. Mutant neonates display respiratory distress, progressive cyanosis, and die within 30 minutes-2 hours after birth. Lung tissues and the diaphragm muscle show aberrant morphology.|C|T|43|36.0|Non-synonymous|Unprocessed|APF-G1
817044|IGL00430|10|100508724|I->L||0.47|Possibly damaging|0.19|tolerated|MGI:2384917|Cep290|centrosomal protein 290 [Source:MGI Symbol;Acc:MGI:2384917]|Heterozygous|Mice homozygous for a spontaneous in-frame deletion display mislocalization of ciliary and phototransduction proteins resulting in early-onset retinal degeneration.|A|T|42|38.5|Non-synonymous|Unprocessed|APF-G1
817045|IGL00430|16|10542445|D->E||0.26|Benign|||MGI:1926236|Dexi|dexamethasone-induced transcript [Source:MGI Symbol;Acc:MGI:1926236]|Heterozygous||A|T|42|35.0|Non-synonymous|Unprocessed|APF-G1
817046|IGL00430|11|100757654|T->A||1.0|Probably damaging||deleterious|MGI:2156184|Kcnh4|potassium voltage-gated channel, subfamily H (eag-related), member 4 [Source:MGI Symbol;Acc:MGI:2156184]|Heterozygous||T|C|40|35.0|Non-synonymous|Unprocessed|APF-G1
817047|IGL00430|1|84763861|H->P||0.1|Benign|0.01|deleterious|MGI:1309481|Trip12|thyroid hormone receptor interactor 12 [Source:MGI Symbol;Acc:MGI:1309481]|Heterozygous||T|G|39|35.0|Non-synonymous|Unprocessed|APF-G1
817048|IGL00430|3|107194728|V->G||1.0|Probably damaging||deleterious|MGI:3037820|Kcna10|potassium voltage-gated channel, shaker-related subfamily, member 10 [Source:MGI Symbol;Acc:MGI:3037820]|Heterozygous||T|G|39|36.0|Non-synonymous|Unprocessed|APF-G1
817049|IGL00430|3|153509403|N->S|||Benign|0.66|tolerated|MGI:1341828|St6galnac3|ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 [Source:MGI Symbol;Acc:MGI:1341828]|Heterozygous||T|C|39|38.0|Non-synonymous|Unprocessed|APF-G1
817050|IGL00430|17|84521775|M->L||0.64|Possibly damaging|1.0|tolerated|MGI:2146813|Plekhh2|pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 [Source:MGI Symbol;Acc:MGI:2146813]|Heterozygous||A|T|38|36.0|Non-synonymous|Unprocessed|APF-G1
817051|IGL00430|8|120033560|R->S||1.0|Probably damaging|0.01|deleterious|MGI:1926142|Crispld2|cysteine-rich secretory protein LCCL domain containing 2 [Source:MGI Symbol;Acc:MGI:1926142]|Heterozygous||A|T|36|36.0|Non-synonymous|Unprocessed|APF-G1
817052|IGL00430|15|55540201|K->N||1.0|Probably damaging|0.12|tolerated|MGI:2137218|Mrpl13|mitochondrial ribosomal protein L13 [Source:MGI Symbol;Acc:MGI:2137218]|Heterozygous||T|A|35|36.0|Non-synonymous|Unprocessed|APF-G1
817053|IGL00430|19|5051376|N->S|||Benign|1.0|tolerated|MGI:2385695|Rin1|Ras and Rab interactor 1 [Source:MGI Symbol;Acc:MGI:2385695]|Heterozygous|Mice homozygous for disruptions in this gene display an enhanced conditioned response in cued conditioning protocols and avoidance learning tests.|A|G|33|35.0|Non-synonymous|Unprocessed|APF-G1
817054|IGL00430|5|30120147|V->M||0.94|Possibly damaging||deleterious|MGI:2135593|Hadha|hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit [Source:MGI Symbol;Acc:MGI:2135593]|Heterozygous|Mice homozygous for disruptions in this gene die within 36 hours with hypoglycemia and liver steatosis.  Liver steatosis and insulin resistance develop in heterozygotes with age.|C|T|30|37.0|Non-synonymous|Unprocessed|APF-G1
817055|IGL00430|17|73494232|V->I||1.0|Probably damaging|0.19|tolerated|MGI:1918935|Galnt14|UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 [Source:MGI Symbol;Acc:MGI:1918935]|Heterozygous||C|T|21|35.0|Non-synonymous|Unprocessed|APF-G1
817056|IGL00430|10|39045704|E->G||0.64|Possibly damaging|0.01|deleterious|MGI:109321|Lama4|laminin, alpha 4 [Source:MGI Symbol;Acc:MGI:109321]|Heterozygous|Homozygotes for targeted null mutations exhibit impaired motor control of the hind limbs associated with improperly positioned synaptic active zones and junctional folds, and prenatal and neonatal hemorrhages associated with capillary defects.|A|G|18|40.0|Non-synonymous|Unprocessed|APF-G1
817057|IGL00430|19|4811426|V->A||1.0|Probably damaging||deleterious|MGI:1929092|Rbm14|RNA binding motif protein 14 [Source:MGI Symbol;Acc:MGI:1929092]|Heterozygous||A|G|13|35.0|Non-synonymous|Unprocessed|APF-G1
817059|IGL00430|19|41877334|Disrupted splicing|||N/A|||MGI:2147437|Rrp12|ribosomal RNA processing 12 homolog (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:2147437]|Heterozygous||A|G|30|35.0|Splice|Unprocessed|APF-G1
817061|IGL00430|11|113709218|Disrupted splicing|||N/A|||MGI:1277182|Cpsf4l|cleavage and polyadenylation specific factor 4-like [Source:MGI Symbol;Acc:MGI:1277182]|Heterozygous||C|T|10|35.0|Splice|Unprocessed|APF-G1
1513999|IGL00648|3|56009260|S->P||0.98|Probably damaging|0.02|deleterious|MGI:1347075|Nbea|neurobeachin [Source:MGI Symbol;Acc:MGI:1347075]|Heterozygous|Mice homozygous for a gene trapped allele or transgene insertion die shortly after birth, are cyanotic, and exhibit no response to tactile stimuli, no spontaneous movement, and impaired CNS synaptic transmission.|A|G|78|38.5|Non-synonymous|Unprocessed|APF-G1
1514000|IGL00648|13|38022993|S->Stop|||N/A|||MGI:1918463|Cage1|cancer antigen 1 [Source:MGI Symbol;Acc:MGI:1918463]|Heterozygous||G|T|57|40.0|Non-synonymous|Unprocessed|APF-G1
1514001|IGL00648|14|31052283|I->F||0.99|Probably damaging|0.03|deleterious|MGI:1923998|Pbrm1|polybromo 1 [Source:MGI Symbol;Acc:MGI:1923998]|Heterozygous|Homozygous null mice display embryonic lethality with hypoplastic cardiac ventricular chambers and malformation of the placenta.|A|T|56|41.0|Non-synonymous|Unprocessed|APF-G1
1514002|IGL00648|8|84842702|D->V|||Unknown|0.03|deleterious|MGI:88252|Calr|calreticulin [Source:MGI Symbol;Acc:MGI:88252]|Heterozygous|Homozygotes for targeted null mutations exhibit decreased cardiac cell mass, increased apoptosis of cardiac myocytes, neural tube defects (sometimes associated with exencephaly), omphalocele, and mid- to late-gestational lethality.|T|A|27|37.0|Non-synonymous|Unprocessed|APF-G1
1514003|IGL00648|10|23985508|V->M||0.04|Benign|0.33|tolerated|MGI:2685074|Taar6|trace amine-associated receptor 6 [Source:MGI Symbol;Acc:MGI:2685074]|Heterozygous||C|T|24|39.0|Non-synonymous|Unprocessed|APF-G1
1514004|IGL00648|13|24460276|K->Stop|||N/A|||MGI:103227|Cmah|cytidine monophospho-N-acetylneuraminic acid hydroxylase [Source:MGI Symbol;Acc:MGI:103227]|Heterozygous|Mice with homozygous mutation of Cmah show subtle incidence of lethality, with slightly abnormal B and T cell physiolgy, including cytokine production in response to stimulation.|A|T|23|40.0|Non-synonymous|Unprocessed|APF-G1
1514005|IGL00648|15|99322670|T->I||0.4|Benign|0.4|tolerated|MGI:109569|Fmnl3|formin-like 3 [Source:MGI Symbol;Acc:MGI:109569]|Heterozygous||G|A|23|39.0|Non-synonymous|Unprocessed|APF-G1
1514006|IGL00648|16|97478399|G->E||0.85|Possibly damaging|0.09|tolerated|MGI:1270150|Fam3b|family with sequence similarity 3, member B [Source:MGI Symbol;Acc:MGI:1270150]|Heterozygous|Mice homozygous for a deletion of this gene display elevated blood glucose in glucose tolerance tests  and elevated blood insulin after glucose injection, probably due to impaired insulin clearance.|C|T|22|37.5|Non-synonymous|Unprocessed|APF-G1
1514007|IGL00648|10|107646716|L->F||0.86|Possibly damaging|0.07|tolerated|MGI:1096349|Ptprq|protein tyrosine phosphatase, receptor type, Q [Source:MGI Symbol;Acc:MGI:1096349]|Heterozygous|Homozygotes for targeted mutations show absence of shaft connectors from vestibular hair bundles, postnatal degeneration in cochlear hair-bundle structure, reduced transducer currents but otherwise normal adaptation properties, a progressive loss of basal-coil cochlear hair cells, and deafness.|G|A|21|39.0|Non-synonymous|Unprocessed|APF-G1
1514008|IGL00648|11|60261116|Y->C||0.43|Possibly damaging|0.16|tolerated|MGI:2443306|Tom1l2|target of myb1-like 2 (chicken) [Source:MGI Symbol;Acc:MGI:2443306]|Heterozygous|Mice homozygous for a hypomorphic gene trap allele show malocclusion, kyphosis, hydrocephaly, patchy hair, splenomegaly, high B- and T-cell counts, thrombopenia, impaired humoral responses, a high frequency of infections and tumors, renal cysts, skin lesions, freezing behavior and sporadic bleeding.|T|C|17|38.0|Non-synonymous|Unprocessed|APF-G1
1514009|IGL00648|11|71092957|T->A|||Benign|0.47|tolerated|MGI:2684861|Nlrp1a|NLR family, pyrin domain containing 1A [Source:MGI Symbol;Acc:MGI:2684861]|Heterozygous||T|C|16|39.0|Non-synonymous|Unprocessed|APF-G1
1514010|IGL00648|6|108851207|Disrupted splicing|||N/A|||MGI:2180139|Edem1|ER degradation enhancer, mannosidase alpha-like 1 [Source:MGI Symbol;Acc:MGI:2180139]|Heterozygous||T|A|39|40.0|Splice|Unprocessed|APF-G1
1514011|IGL00648|2|105842366|Disrupted splicing|||N/A|||MGI:1925016|Elp4|elongation protein 4 homolog (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1925016]|Heterozygous||A|T|22|40.0|Splice|Unprocessed|APF-G1
1514513|IGL00639|4|85006434|E->G||0.02|Benign|0.04|deleterious|MGI:2443104|Cntln|centlein, centrosomal protein [Source:MGI Symbol;Acc:MGI:2443104]|Heterozygous||A|G|112|40.0|Non-synonymous|Unprocessed|APF-G1
1514514|IGL00639|13|34899173|N->S|||Unknown|0.02|deleterious|MGI:109584|Prpf4b|PRP4 pre-mRNA processing factor 4 homolog B (yeast) [Source:MGI Symbol;Acc:MGI:109584]|Heterozygous||A|G|102|39.0|Non-synonymous|Unprocessed|APF-G1
1514515|IGL00639|6|119370168|C->Stop|||N/A|||MGI:93830|Adipor2|adiponectin receptor 2 [Source:MGI Symbol;Acc:MGI:93830]|Heterozygous|Mice homozygous for disruptions in this gene display small testes and epididymis, degeneration of the seminiferous tubules, and abnormal sperm maturation.|A|T|94|40.0|Non-synonymous|Unprocessed|APF-G1
1514516|IGL00639|8|33575311|S->P|||N/A|0.18|tolerated|MGI:1934816|Tex15|testis expressed gene 15 [Source:MGI Symbol;Acc:MGI:1934816]|Heterozygous|Male mice are infertile due to arrest of meiosis stemming from failure to repair double-strand breaks.  However, female mice are fertile.|T|C|92|37.0|Non-synonymous|Unprocessed|APF-G1
1514517|IGL00639|3|49755616|I->V||0.11|Benign|0.42|tolerated|MGI:1920423|Pcdh18|protocadherin 18 [Source:MGI Symbol;Acc:MGI:1920423]|Heterozygous||T|C|67|40.0|Non-synonymous|Unprocessed|APF-G1
1514518|IGL00639|13|112549559|Y->Stop|||N/A|||MGI:2180511|Il31ra|interleukin 31 receptor A [Source:MGI Symbol;Acc:MGI:2180511]|Heterozygous|Homozygous null mice display no apparent abnormalities.|A|T|40|39.5|Non-synonymous|Unprocessed|APF-G1
1514519|IGL00639|5|145244145|Y->C||1.0|Probably damaging||deleterious|MGI:1919861|Zfp655|zinc finger protein 655 [Source:MGI Symbol;Acc:MGI:1919861]|Heterozygous||A|G|26|39.0|Non-synonymous|Unprocessed|APF-G1
1514520|IGL00639|1|65062091|R->Q||0.94|Possibly damaging|0.15|tolerated|MGI:88524|Crygd|crystallin, gamma D [Source:MGI Symbol;Acc:MGI:88524]|Heterozygous|Heterozygotes for a spontaneous mutation exhibit a dense nuclear cataract and mild microphthalmia by 2-months of age, followed by posterior capsular rupture into the posterior vitreous by 3-months. In homozygotes, the microphthalmia is more pronounced.|C|T|23|39.0|Non-synonymous|Unprocessed|APF-G1
1514521|IGL00639|4|126165578|G->S|||Benign|1.0|tolerated|MGI:2442637|Thrap3|thyroid hormone receptor associated protein 3 [Source:MGI Symbol;Acc:MGI:2442637]|Heterozygous||C|T|20|39.5|Non-synonymous|Unprocessed|APF-G1
1514522|IGL00639|8|116956657|D->G||0.98|Probably damaging||deleterious|MGI:2682328|Atmin|ATM interactor [Source:MGI Symbol;Acc:MGI:2682328]|Heterozygous||A|G|20|37.5|Non-synonymous|Unprocessed|APF-G1
1514523|IGL00639|5|151042239|E->G||1.0|Probably damaging|0.01|deleterious|MGI:2385331|Stard13|StAR-related lipid transfer (START) domain containing 13 [Source:MGI Symbol;Acc:MGI:2385331]|Heterozygous|Mice homozygous for a knock-out allele exhibit small body size, decreased weight, and reduced adipose tissue. Mice homozygous for another knock-out allele exhibit increased angiogenesis in matrigel plugs and implanted tumors.|T|C|19|40.0|Non-synonymous|Unprocessed|APF-G1
1514524|IGL00639|7|25343684|F->L||0.98|Probably damaging|0.02|deleterious|MGI:2446294|Megf8|multiple EGF-like-domains 8 [Source:MGI Symbol;Acc:MGI:2446294]|Heterozygous||T|C|16|37.5|Non-synonymous|Unprocessed|APF-G1
1514525|IGL00639|12|106055916|Disrupted splicing|||N/A|||MGI:1261847|Vrk1|vaccinia related kinase 1 [Source:MGI Symbol;Acc:MGI:1261847]|Heterozygous|Homozygotes for a gene trap allele yielding nearly full-length protein levels are fertile and overtly normal. Homozygotes for a hypomorphic gene trap allele are sterile; male infertility is due to progressive loss of proliferating spermatogonia leading to lack of meiotic cells and mature sperm.|T|A|29|39.0|Splice|Unprocessed|APF-G1
1514800|IGL00640|9|95865052|V->A||1.0|Probably damaging|0.01|deleterious|MGI:108028|Atr|ataxia telangiectasia and Rad3 related [Source:MGI Symbol;Acc:MGI:108028]|Heterozygous|Mice homozygous for a knock-out allele exhibit early embryonic lethality.  Mice heterozygous for a knock-out allele exhibit premature death and increased tumor incidence.|T|C|180|40.0|Non-synonymous|Unprocessed|APF-G1
1514801|IGL00640|11|41971772|I->L||0.68|Possibly damaging|0.02|deleterious|MGI:95623|Gabrg2|gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 [Source:MGI Symbol;Acc:MGI:95623]|Heterozygous|Homozygotes for a targeted null mutation exhibit retarded postnatal growth, impaired sensorimotor function, and greatly reduced lifespan. Heterozygotes show enhanced anxiety-related behaviors.|T|G|64|39.0|Non-synonymous|Unprocessed|APF-G1
1514802|IGL00640|15|35417577|I->L|||Benign|0.77|tolerated|MGI:1916380|Vps13b|vacuolar protein sorting 13B (yeast) [Source:MGI Symbol;Acc:MGI:1916380]|Heterozygous||A|T|64|39.0|Non-synonymous|Unprocessed|APF-G1
1514803|IGL00640|12|81729698|T->I||0.01|Benign|0.16|tolerated|MGI:2449952|Map3k9|mitogen-activated protein kinase kinase kinase 9 [Source:MGI Symbol;Acc:MGI:2449952]|Heterozygous|Mice homozygous for a reporter/null allele exhibit normal development, reproduction and lifespan.|G|A|57|39.0|Non-synonymous|Unprocessed|APF-G1
1514804|IGL00640|1|65062091|R->Q||0.94|Possibly damaging|0.15|tolerated|MGI:88524|Crygd|crystallin, gamma D [Source:MGI Symbol;Acc:MGI:88524]|Heterozygous|Heterozygotes for a spontaneous mutation exhibit a dense nuclear cataract and mild microphthalmia by 2-months of age, followed by posterior capsular rupture into the posterior vitreous by 3-months. In homozygotes, the microphthalmia is more pronounced.|C|T|31|39.0|Non-synonymous|Unprocessed|APF-G1
1514805|IGL00640|5|26104155|R->G||0.99|Probably damaging||deleterious|MGI:3036277|5031410i06rik|RIKEN cDNA 5031410I06 gene [Source:MGI Symbol;Acc:MGI:3036277]|Heterozygous||T|C|30|38.0|Non-synonymous|Unprocessed|APF-G1
1514806|IGL00640|8|90986132|E->G|||Unknown|0.02|deleterious|MGI:1924001|Chd9|chromodomain helicase DNA binding protein 9 [Source:MGI Symbol;Acc:MGI:1924001]|Heterozygous||A|G|28|41.0|Non-synonymous|Unprocessed|APF-G1
1514807|IGL00640|1|171601879|V->D||0.16|Benign|0.01|deleterious|MGI:96885|Ly9|lymphocyte antigen 9 [Source:MGI Symbol;Acc:MGI:96885]|Heterozygous|This locus controls an antigen on thymocytes, lymphocytes and bone marrow cells. The a allele determines Ly9.1 antigen in A/J, 129/Re, BALB/c and C3H/He; the b allele determines antigen Ly9.2 in the C57 family of strains, HTI/Go, MA/My, F/St and C58/Lw. Null mutants are viable, healthy and fertile.|A|T|21|38.0|Non-synonymous|Unprocessed|APF-G1
1514808|IGL00640|12|51389315|D->E||0.04|Benign|0.16|tolerated|MGI:1924233|Scfd1|Sec1 family domain containing 1 [Source:MGI Symbol;Acc:MGI:1924233]|Heterozygous||T|A|20|39.0|Non-synonymous|Unprocessed|APF-G1
1514809|IGL00640|6|60977513|L->P|||Benign|0.13|tolerated|MGI:1918195|Mmrn1|multimerin 1 [Source:MGI Symbol;Acc:MGI:1918195]|Heterozygous||T|C|20|40.0|Non-synonymous|Unprocessed|APF-G1
1514810|IGL00640|3|36908218|H->Q||0.98|Probably damaging|0.07|tolerated|MGI:2444631|4932438a13rik|RIKEN cDNA 4932438A13 gene [Source:MGI Symbol;Acc:MGI:2444631]|Heterozygous||C|A|19|40.0|Non-synonymous|Unprocessed|APF-G1
1514811|IGL00640|3|102158229|Disrupted splicing|||N/A|||MGI:2159344|Vangl1|vang-like 1 (van gogh, Drosophila) [Source:MGI Symbol;Acc:MGI:2159344]|Heterozygous|Mice homozygous for a gene trapped allele display abnormal orientation of cochlear hair cell stereociliary bundles but do not develop neural tube or cardiac outflow tract abnormalities.|T|A|92|39.0|Splice|Unprocessed|APF-G1
1515815|IGL00642|X|81420938|R->G|||Unknown|0.01|deleterious|MGI:3045300|4930595m18rik|RIKEN cDNA 4930595M18 gene [Source:MGI Symbol;Acc:MGI:3045300]|Heterozygous||T|C|91|40.0|Non-synonymous|Unprocessed|APF-G1
1515816|IGL00642|5|62733058|R->Stop|||N/A|||MGI:2684416|Arap2|ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 [Source:MGI Symbol;Acc:MGI:2684416]|Heterozygous||G|A|80|39.0|Non-synonymous|Unprocessed|APF-G1
1515817|IGL00642|5|106968860|I->V|||Benign|1.0|tolerated|MGI:1309511|Cdc7|cell division cycle 7 (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1309511]|Heterozygous|Homozygous mutation of this gene results in embryonic lethality between E3.5-E6.5. In conjunction with a Trp53-null allele, double homozygous mutant embryos survive up to E8.5.|A|G|51|38.0|Non-synonymous|Unprocessed|APF-G1
1515818|IGL00642|17|80274976|F->S|||Benign|0.16|tolerated|MGI:2147067|Dhx57|DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 [Source:MGI Symbol;Acc:MGI:2147067]|Heterozygous||A|G|47|41.0|Non-synonymous|Unprocessed|APF-G1
1515819|IGL00642|15|65855417|D->G||0.18|Benign|0.01|deleterious|MGI:1923990|Efr3a|EFR3 homolog A (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1923990]|Heterozygous||A|G|45|40.0|Non-synonymous|Unprocessed|APF-G1
1515820|IGL00642|9|4330169|Y->F|||Benign|0.71|tolerated|MGI:1916399|Kbtbd3|kelch repeat and BTB (POZ) domain containing 3 [Source:MGI Symbol;Acc:MGI:1916399]|Heterozygous||A|T|41|39.0|Non-synonymous|Unprocessed|APF-G1
1515821|IGL00642|17|71390432|E->G||0.92|Possibly damaging|0.05|deleterious|MGI:1921605|Smchd1|SMC hinge domain containing 1 [Source:MGI Symbol;Acc:MGI:1921605]|Heterozygous||T|C|40|41.0|Non-synonymous|Unprocessed|APF-G1
1515822|IGL00642|15|11394372|Y->H||0.9|Possibly damaging||deleterious|MGI:106314|Tars|threonyl-tRNA synthetase [Source:MGI Symbol;Acc:MGI:106314]|Heterozygous||A|G|38|39.0|Non-synonymous|Unprocessed|APF-G1
1515823|IGL00642|9|98579033|L->V||0.97|Probably damaging|0.01|deleterious|MGI:1354962|Copb2|coatomer protein complex, subunit beta 2 (beta prime) [Source:MGI Symbol;Acc:MGI:1354962]|Heterozygous||T|G|32|39.0|Non-synonymous|Unprocessed|APF-G1
1515824|IGL00642|5|3960842|Q->R||0.81|Possibly damaging|0.03|deleterious|MGI:2178217|Akap9|A kinase (PRKA) anchor protein (yotiao) 9 [Source:MGI Symbol;Acc:MGI:2178217]|Heterozygous||A|G|19|39.0|Non-synonymous|Unprocessed|APF-G1
1515825|IGL00642|10|88954667|E->K||1.0|Probably damaging||deleterious|MGI:2443344|Ano4|anoctamin 4 [Source:MGI Symbol;Acc:MGI:2443344]|Heterozygous||C|T|17|38.0|Non-synonymous|Unprocessed|APF-G1
1516816|IGL00644|18|65997622|Q->Stop|||N/A|||MGI:1917611|Lman1|lectin, mannose-binding, 1 [Source:MGI Symbol;Acc:MGI:1917611]|Heterozygous||G|A|54|40.0|Non-synonymous|Unprocessed|APF-G1
1516817|IGL00644|10|68533900|E->K|||Benign|0.04|deleterious|MGI:1920537|1700040l02rik|RIKEN cDNA 1700040L02 gene [Source:MGI Symbol;Acc:MGI:1920537]|Heterozygous||C|T|40|41.0|Non-synonymous|Unprocessed|APF-G1
1516818|IGL00644|2|125743844|P->S||1.0|Probably damaging|0.01|deleterious|MGI:1917604|Secisbp2l|SECIS binding protein 2-like [Source:MGI Symbol;Acc:MGI:1917604]|Heterozygous||G|A|40|40.0|Non-synonymous|Unprocessed|APF-G1
1516819|IGL00644|17|58888110|D->G|||Benign|1.0|tolerated|MGI:1916489|2610034m16rik|RIKEN cDNA 2610034M16 gene [Source:MGI Symbol;Acc:MGI:1916489]|Heterozygous||T|C|28|40.0|Non-synonymous|Unprocessed|APF-G1
1516820|IGL00644|5|67016552|A->S|||Benign|0.75|tolerated|MGI:1924819|Limch1|LIM and calponin homology domains 1 [Source:MGI Symbol;Acc:MGI:1924819]|Heterozygous||G|T|18|40.5|Non-synonymous|Unprocessed|APF-G1
1516821|IGL00644|3|158202368|Q->Stop|||N/A|||MGI:2676665|Lrrc7|leucine rich repeat containing 7 [Source:MGI Symbol;Acc:MGI:2676665]|Heterozygous||G|A|17|40.0|Non-synonymous|Unprocessed|APF-G1
1516822|IGL00644|X|21739656|I->K||0.27|Benign|0.08|tolerated|MGI:1890216|Slc6a14|solute carrier family 6 (neurotransmitter transporter), member 14 [Source:MGI Symbol;Acc:MGI:1890216]|Heterozygous||T|A|16|39.0|Non-synonymous|Unprocessed|APF-G1
1516823|IGL00644|10|82885176|Disrupted splicing|||N/A|||MGI:1354175|Txnrd1|thioredoxin reductase 1 [Source:MGI Symbol;Acc:MGI:1354175]|Heterozygous|Homozygous null mice exhibit early embryonic lethality (by E10.5) and display severe growth retardation and fail to turn.  Embryos also exhibit decreased cell proliferation.|T|A|39|39.0|Splice|Unprocessed|APF-G1
1517281|IGL00645|2|80654832|F->L||1.0|Probably damaging||deleterious|MGI:1916732|Nup35|nucleoporin 35 [Source:MGI Symbol;Acc:MGI:1916732]|Heterozygous||T|A|114|40.0|Non-synonymous|Unprocessed|APF-G1
1517282|IGL00645|15|71462546|V->A||0.97|Probably damaging|0.34|tolerated|MGI:1917613|Fam135b|family with sequence similarity 135, member B [Source:MGI Symbol;Acc:MGI:1917613]|Heterozygous||A|G|50|40.0|Non-synonymous|Unprocessed|APF-G1
1517283|IGL00645|13|4576313|D->G||1.0|Probably damaging||deleterious|MGI:1924587|Akr1c21|aldo-keto reductase family 1, member C21 [Source:MGI Symbol;Acc:MGI:1924587]|Heterozygous||A|G|37|39.0|Non-synonymous|Unprocessed|APF-G1
1517284|IGL00645|2|149409979|C->S||1.0|Probably damaging||deleterious|MGI:1930004|Cst10|cystatin 10 (chondrocytes) [Source:MGI Symbol;Acc:MGI:1930004]|Heterozygous|Mice homozygous for a knock-out allele display reduced chondrocyte calcification during endochondral ossification both under physiological and pathological conditions.|T|A|26|40.0|Non-synonymous|Unprocessed|APF-G1
1517285|IGL00645|1|55061309|T->A|||Benign|0.48|tolerated|MGI:1915126|Coq10b|coenzyme Q10 homolog B (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1915126]|Heterozygous||A|G|25|40.0|Non-synonymous|Unprocessed|APF-G1
1517286|IGL00645|12|104217340|F->L||0.91|Possibly damaging|0.09|tolerated|MGI:2182838|Serpina3f|serine (or cysteine) peptidase inhibitor, clade A, member 3F [Source:MGI Symbol;Acc:MGI:2182838]|Heterozygous||T|C|22|39.5|Non-synonymous|Unprocessed|APF-G1
1517287|IGL00645|3|101283223|N->D||0.18|Benign|0.13|tolerated|MGI:88320|Cd2|CD2 antigen [Source:MGI Symbol;Acc:MGI:88320]|Heterozygous|Homozygous mutation of this gene does not appear to result in a phenotype.|T|C|22|40.0|Non-synonymous|Unprocessed|APF-G1
1517288|IGL00645|3|107195465|E->K||0.99|Probably damaging|0.02|deleterious|MGI:3037820|Kcna10|potassium voltage-gated channel, shaker-related subfamily, member 10 [Source:MGI Symbol;Acc:MGI:3037820]|Heterozygous||G|A|20|38.5|Non-synonymous|Unprocessed|APF-G1
1517289|IGL00645|1|157566719|V->D||1.0|Probably damaging||deleterious|MGI:2148802|Sec16b|SEC16 homolog B (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:2148802]|Heterozygous||T|A|19|36.0|Non-synonymous|Unprocessed|APF-G1
1517290|IGL00645|11|98805421|C->S||0.98|Probably damaging|0.01|deleterious|MGI:1921276|Msl1|male-specific lethal 1 homolog (Drosophila) [Source:MGI Symbol;Acc:MGI:1921276]|Heterozygous||T|A|19|37.0|Non-synonymous|Unprocessed|APF-G1
1517291|IGL00645|2|125317103|Disrupted splicing|||N/A|||MGI:95489|Fbn1|fibrillin 1 [Source:MGI Symbol;Acc:MGI:95489]|Heterozygous|Lethality among homozygotes for spontaneous and targeted mutations ranges from embryonic death to death around 4 months. Abnormalities include vascular defects, excess bone growth, connective tissue hyperplasia, and lung emphysema.|A|G|17|39.0|Splice|Unprocessed|APF-G1
1517764|IGL00646|10|100501154|V->A||0.04|Benign||deleterious|MGI:2384917|Cep290|centrosomal protein 290 [Source:MGI Symbol;Acc:MGI:2384917]|Heterozygous|Mice homozygous for a spontaneous in-frame deletion display mislocalization of ciliary and phototransduction proteins resulting in early-onset retinal degeneration.|T|C|45|37.0|Non-synonymous|Unprocessed|APF-G1
1517765|IGL00646|2|178374459|I->V||0.44|Possibly damaging|0.81|tolerated|MGI:1933281|Sycp2|synaptonemal complex protein 2 [Source:MGI Symbol;Acc:MGI:1933281]|Heterozygous|Male mice homozygous for a knock-out allele are sterile due to lack of axial element formation and subsequent failure of chromosome synapsis in prophase I spermatocytes, while females are subfertile with a sharply reduced litter size.|T|C|45|40.0|Non-synonymous|Unprocessed|APF-G1
1517766|IGL00646|19|47117328|T->A||0.47|Possibly damaging|0.22|tolerated|MGI:1341788|Pdcd11|programmed cell death 11 [Source:MGI Symbol;Acc:MGI:1341788]|Heterozygous||A|G|31|38.0|Non-synonymous|Unprocessed|APF-G1
1517767|IGL00646|5|123739622|R->G|||Unknown|0.16|tolerated|MGI:1913489|Rsrc2|arginine/serine-rich coiled-coil 2 [Source:MGI Symbol;Acc:MGI:1913489]|Heterozygous||T|C|30|39.0|Non-synonymous|Unprocessed|APF-G1
1517768|IGL00646|11|107173460|V->I|||Benign|1.0|tolerated|MGI:1916229|Nol11|nucleolar protein 11 [Source:MGI Symbol;Acc:MGI:1916229]|Heterozygous||C|T|29|39.0|Non-synonymous|Unprocessed|APF-G1
1517769|IGL00646|7|24228812|K->Stop|||N/A|||MGI:1929099|Zfp109|zinc finger protein 109 [Source:MGI Symbol;Acc:MGI:1929099]|Heterozygous||T|A|26|38.0|Non-synonymous|Unprocessed|APF-G1
1517770|IGL00646|18|50164845|F->L|||Benign|1.0|tolerated|MGI:105089|Hsd17b4|hydroxysteroid (17-beta) dehydrogenase 4 [Source:MGI Symbol;Acc:MGI:105089]|Heterozygous|Mice homozygous for disruptions in this gene have abnormalities infatty acid metabolism.  The mice have retarded growth and abnormal bile salt composition.|T|A|20|39.0|Non-synonymous|Unprocessed|APF-G1
1517771|IGL00646|14|65921156|K->Stop|||N/A|||MGI:2444418|Scara3|scavenger receptor class A, member 3 [Source:MGI Symbol;Acc:MGI:2444418]|Heterozygous||T|A|17|37.0|Non-synonymous|Unprocessed|APF-G1
1517772|IGL00646|19|39513491|Disrupted splicing|||N/A|||MGI:1306818|Cyp2c39|cytochrome P450, family 2, subfamily c, polypeptide 39 [Source:MGI Symbol;Acc:MGI:1306818]|Heterozygous||T|A|90|40.0|Splice|Unprocessed|APF-G1
1518245|IGL00647|15|6483083|H->N||0.01|Benign|0.4|tolerated|MGI:1098282|C9|complement component 9 [Source:MGI Symbol;Acc:MGI:1098282]|Heterozygous||C|A|103|39.0|Non-synonymous|Unprocessed|APF-G1
1518246|IGL00647|13|61162742|N->S||0.99|Probably damaging|0.02|deleterious|MGI:1861723|Ctsr|cathepsin R [Source:MGI Symbol;Acc:MGI:1861723]|Heterozygous||T|C|46|40.0|Non-synonymous|Unprocessed|APF-G1
1518247|IGL00647|19|40914686|P->S||0.99|Probably damaging|0.92|tolerated|MGI:1919922|Zfp518a|zinc finger protein 518A [Source:MGI Symbol;Acc:MGI:1919922]|Heterozygous||C|T|38|40.0|Non-synonymous|Unprocessed|APF-G1
1518248|IGL00647|15|79671898|F->I||1.0|Probably damaging||deleterious|MGI:2450248|Tomm22|translocase of outer mitochondrial membrane 22 homolog (yeast) [Source:MGI Symbol;Acc:MGI:2450248]|Heterozygous||T|A|24|39.5|Non-synonymous|Unprocessed|APF-G1
1518249|IGL00647|6|122526016|V->M||0.67|Possibly damaging|0.01|deleterious|MGI:1354387|Mfap5|microfibrillar associated protein 5 [Source:MGI Symbol;Acc:MGI:1354387]|Heterozygous||G|A|23|39.0|Non-synonymous|Unprocessed|APF-G1
1518250|IGL00647|8|92830684|T->A|||Benign|0.81|tolerated|MGI:97009|Mmp2|matrix metallopeptidase 2 [Source:MGI Symbol;Acc:MGI:97009]|Heterozygous|Homozygotes for a targeted null mutation exhibit slightly delayed growth, reduced neovascularization, retarded tumor progression, an exaggerated asthma response to allergens, and impaired branching morphogenesis of the mammary gland.|A|G|22|37.0|Non-synonymous|Unprocessed|APF-G1
1518251|IGL00647|1|34552539|T->A|||Unknown|0.22|tolerated|MGI:1270857|Prss40|protease, serine, 40 [Source:MGI Symbol;Acc:MGI:1270857]|Heterozygous||T|C|21|37.0|Non-synonymous|Unprocessed|APF-G1
1518252|IGL00647|12|91537500|E->G||1.0|Probably damaging|0.06|tolerated|MGI:98849|Tshr|thyroid stimulating hormone receptor [Source:MGI Symbol;Acc:MGI:98849]|Heterozygous|Mutations in this gene exhibit profound hypothyroidism, developmental and growth retardation,  impaired hearing with cochlear defects, and infertility. One mutation results in high postweaning mortality.|A|G|19|37.0|Non-synonymous|Unprocessed|APF-G1
1518253|IGL00647|17|85063805|V->D||1.0|Probably damaging||deleterious|MGI:1195264|Slc3a1|solute carrier family 3, member 1 [Source:MGI Symbol;Acc:MGI:1195264]|Heterozygous|Mutation of this locus results in renal absorption defects and cystine urolithiasis. Homozygous mutant mice serve as a mouse model for human cystinuria type I.|T|A|16|39.5|Non-synonymous|Unprocessed|APF-G1
1518254|IGL00647|2|101630617|D->G||0.15|Benign|0.06|tolerated|MGI:97849|Rag2|recombination activating gene 2 [Source:MGI Symbol;Acc:MGI:97849]|Heterozygous|Homozygotes for targeted null mutations exhibit arrested development of T and B cell maturation at the CD4-8- thymocyte or B220+/CD43+pro-B cell stage due to inability to undergo V(D)J recombination.|A|G|16|39.0|Non-synonymous|Unprocessed|APF-G1
1518255|IGL00647|12|4613311|Disrupted splicing|||N/A|||MGI:1338049|Itsn2|intersectin 2 [Source:MGI Symbol;Acc:MGI:1338049]|Heterozygous||T|C|31|40.0|Splice|Unprocessed|APF-G1
1518256|IGL00647|14|46817381|Disrupted splicing|||N/A|||MGI:1927133|Gmfb|glia maturation factor, beta [Source:MGI Symbol;Acc:MGI:1927133]|Heterozygous|Homozygous null mice display impaired balance and eye blink conditioning behavior and abnormal metencephalon morphology.|C|T|22|39.0|Splice|Unprocessed|APF-G1
1518765|IGL00649|9|100776808|R->S||0.98|Probably damaging|0.05|tolerated|MGI:1098658|Stag1|stromal antigen 1 [Source:MGI Symbol;Acc:MGI:1098658]|Heterozygous||A|T|69|40.0|Non-synonymous|Unprocessed|APF-G1
1518766|IGL00649|16|4039024|Y->C||1.0|Probably damaging||deleterious|MGI:103157|Dnase1|deoxyribonuclease I [Source:MGI Symbol;Acc:MGI:103157]|Heterozygous|Some heterozygote and homozygote null mice have autoimmune symptoms similar to systemic lupus erythematosus.  These include enlarged lymph nodes, circulating auto-antibodies, kidney inflammation and premature death.|A|G|19|38.0|Non-synonymous|Unprocessed|APF-G1
1518767|IGL00649|2|32006721|F->L||0.02|Benign|0.02|deleterious|MGI:1095411|Nup214|nucleoporin 214 [Source:MGI Symbol;Acc:MGI:1095411]|Heterozygous|Embryos homozygous for a null mutation die between 4.0 and 4.5 dpc, following depletion of maternally-derived gene product.  In vitro, cultured 3.5-dpc mutant embryos arrest in the G2 phase, and show blastocoel contraction with defects in NLS-mediated protein import and polyadenylated RNA export.|T|A|16|39.0|Non-synonymous|Unprocessed|APF-G1
1518768|IGL00649|7|58794482|T->A||0.01|Benign|0.16|tolerated|MGI:1330809|Atp10a|ATPase, class V, type 10A [Source:MGI Symbol;Acc:MGI:1330809]|Heterozygous|Disruption of this gene at the distal end of the <A HREF= http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:3043517>p<sup>23DFiOD</sup></A> deletion may be responsible for the obesity phenotypes associate with that deletion.|A|G|16|39.0|Non-synonymous|Unprocessed|APF-G1
1518769|IGL00649|2|121397892|Disrupted splicing|||N/A|||MGI:2387404|Catsper2|cation channel, sperm associated 2 [Source:MGI Symbol;Acc:MGI:2387404]|Heterozygous|Homozygous null male mice are infertile due to a sperm motility defect.|T|A|27|40.0|Splice|Unprocessed|APF-G1
1520737|IGL00654|14|68649428|T->A|||Benign|0.57|tolerated|MGI:105988|Adam28|a disintegrin and metallopeptidase domain 28 [Source:MGI Symbol;Acc:MGI:105988]|Heterozygous||T|C|48|37.5|Non-synonymous|Unprocessed|APF-G1
1520738|IGL00654|7|107196144|L->F||1.0|Probably damaging|0.01|deleterious|MGI:1924108|Nlrp14|NLR family, pyrin domain containing 14 [Source:MGI Symbol;Acc:MGI:1924108]|Heterozygous||G|T|48|39.0|Non-synonymous|Unprocessed|APF-G1
1520739|IGL00654|14|78609593|M->R||0.71|Possibly damaging|0.01|deleterious|MGI:2444188|Dgkh|diacylglycerol kinase, eta [Source:MGI Symbol;Acc:MGI:2444188]|Heterozygous||A|C|43|38.0|Non-synonymous|Unprocessed|APF-G1
1520740|IGL00654|4|94827301|T->A|||Benign|0.72|tolerated|MGI:98664|Tek|endothelial-specific receptor tyrosine kinase [Source:MGI Symbol;Acc:MGI:98664]|Heterozygous|Homozygous mutation of this gene results in embryonic lethality during organogenesis, impaired vascular branching in the embryo and yolk sac, abnormal cardiac development, and in some cases hemorrhages.|A|G|38|37.5|Non-synonymous|Unprocessed|APF-G1
1520741|IGL00654|10|52312849|I->L|||Benign|1.0|tolerated|MGI:1913936|Dcbld1|discoidin, CUB and LCCL domain containing 1 [Source:MGI Symbol;Acc:MGI:1913936]|Heterozygous||A|C|32|39.0|Non-synonymous|Unprocessed|APF-G1
1520742|IGL00654|1|65062091|R->Q||0.94|Possibly damaging|0.15|tolerated|MGI:88524|Crygd|crystallin, gamma D [Source:MGI Symbol;Acc:MGI:88524]|Heterozygous|Heterozygotes for a spontaneous mutation exhibit a dense nuclear cataract and mild microphthalmia by 2-months of age, followed by posterior capsular rupture into the posterior vitreous by 3-months. In homozygotes, the microphthalmia is more pronounced.|C|T|28|40.0|Non-synonymous|Unprocessed|APF-G1
1520743|IGL00654|4|116692965|D->N|||Benign|0.08|tolerated|MGI:99523|Prdx1|peroxiredoxin 1 [Source:MGI Symbol;Acc:MGI:99523]|Heterozygous|Mutant mice exhibit defects in antioxidant defense that manifest as hemolytic anemia and malignancies. The phenotype is more severe in homozygous mutant mice which die prematurely.|G|A|26|39.0|Non-synonymous|Unprocessed|APF-G1
1520744|IGL00654|13|93094161|S->L||0.1|Benign|0.05|tolerated|MGI:1923719|Cmya5|cardiomyopathy associated 5 [Source:MGI Symbol;Acc:MGI:1923719]|Heterozygous||G|A|24|40.0|Non-synonymous|Unprocessed|APF-G1
1520745|IGL00654|4|116692950|R->C||0.12|Benign|0.08|tolerated|MGI:99523|Prdx1|peroxiredoxin 1 [Source:MGI Symbol;Acc:MGI:99523]|Heterozygous|Mutant mice exhibit defects in antioxidant defense that manifest as hemolytic anemia and malignancies. The phenotype is more severe in homozygous mutant mice which die prematurely.|C|T|24|39.0|Non-synonymous|Unprocessed|APF-G1
1520746|IGL00654|10|45115173|R->W||1.0|Probably damaging||deleterious|MGI:1270863|Prep|prolyl endopeptidase [Source:MGI Symbol;Acc:MGI:1270863]|Heterozygous|Mice homozygous for a gene trap allele exhibit sex-dependent resistance to diet-induced obesity and adiposity.  Mice heterozygous for a gene trap allele exhibit maternal inheritance influenced increase in body weight, organ weight, and adiposity.|C|T|22|37.0|Non-synonymous|Unprocessed|APF-G1
1520747|IGL00654|10|21141826|D->G|||Benign|0.19|tolerated|MGI:97249|Myb|myeloblastosis oncogene [Source:MGI Symbol;Acc:MGI:97249]|Heterozygous|Mice homozygous for deficient alleles of this gene display severe hematopoietic abnormalities. Red and white blood cells and platelets are all affected.|T|C|20|38.5|Non-synonymous|Unprocessed|APF-G1
1520748|IGL00654|16|5087308|I->V||0.88|Possibly damaging|0.04|deleterious|MGI:1194898|Ppl|periplakin [Source:MGI Symbol;Acc:MGI:1194898]|Heterozygous|Homozygous null mice are fertile and grossly normal with no apparent skin abnormalities.|T|C|20|39.5|Non-synonymous|Unprocessed|APF-G1
1520749|IGL00654|18|37443721|D->V||0.05|Benign|0.06|tolerated|MGI:2136748|Pcdhb13|protocadherin beta 13 [Source:MGI Symbol;Acc:MGI:2136748]|Heterozygous||A|T|20|38.5|Non-synonymous|Unprocessed|APF-G1
1520750|IGL00654|6|72328624|L->P||1.0|Probably damaging|0.01|deleterious|MGI:107622|Usp39|ubiquitin specific peptidase 39 [Source:MGI Symbol;Acc:MGI:107622]|Heterozygous||A|G|20|39.0|Non-synonymous|Unprocessed|APF-G1
1520751|IGL00654|15|82314210|V->A||0.02|Benign|0.47|tolerated|MGI:1921966|Wbp2nl|WBP2 N-terminal like [Source:MGI Symbol;Acc:MGI:1921966]|Heterozygous||T|C|17|38.0|Non-synonymous|Unprocessed|APF-G1
1520752|IGL00654|4|126165578|G->S|||Benign|1.0|tolerated|MGI:2442637|Thrap3|thyroid hormone receptor associated protein 3 [Source:MGI Symbol;Acc:MGI:2442637]|Heterozygous||C|T|17|36.0|Non-synonymous|Unprocessed|APF-G1
1520753|IGL00654|4|128617440|G->E||0.99|Probably damaging|1.0|tolerated|MGI:3045221|Tlr12|toll-like receptor 12 [Source:MGI Symbol;Acc:MGI:3045221]|Heterozygous||C|T|17|39.0|Non-synonymous|Unprocessed|APF-G1
1520754|IGL00654|1|60195011|Disrupted splicing|||N/A|||MGI:2444343|Nbeal1|neurobeachin like 1 [Source:MGI Symbol;Acc:MGI:2444343]|Heterozygous||A|G|73|41.0|Splice|Unprocessed|APF-G1
1520755|IGL00654|5|107603631|Disrupted splicing|||N/A|||MGI:2141142|Rpap2|RNA polymerase II associated protein 2 [Source:MGI Symbol;Acc:MGI:2141142]|Heterozygous||A|T|69|39.0|Splice|Unprocessed|APF-G1
1520756|IGL00654|16|32824377|Disrupted splicing|||N/A|||MGI:1915160|1700021k19rik|RIKEN cDNA 1700021K19 gene [Source:MGI Symbol;Acc:MGI:1915160]|Heterozygous||A|T|23|34.0|Splice|Unprocessed|APF-G1
1520757|IGL00654|5|129854077|Disrupted splicing|||N/A|||MGI:1915152|Sumf2|sulfatase modifying factor 2 [Source:MGI Symbol;Acc:MGI:1915152]|Heterozygous||G|T|23|37.0|Splice|Unprocessed|APF-G1
1520758|IGL00654|14|31032404|Disrupted splicing|||N/A|||MGI:1923998|Pbrm1|polybromo 1 [Source:MGI Symbol;Acc:MGI:1923998]|Heterozygous|Homozygous null mice display embryonic lethality with hypoplastic cardiac ventricular chambers and malformation of the placenta.|T|A|16|40.0|Splice|Unprocessed|APF-G1
1521269|IGL00655|16|34678420|G->C||1.0|Probably damaging|0.03|deleterious|MGI:1923628|Ropn1|ropporin, rhophilin associated protein 1 [Source:MGI Symbol;Acc:MGI:1923628]|Heterozygous||G|T|116|40.0|Non-synonymous|Unprocessed|APF-G1
1521270|IGL00655|3|155054555|I->F||0.04|Benign|0.15|tolerated|MGI:2443276|Tnni3k|TNNI3 interacting kinase [Source:MGI Symbol;Acc:MGI:2443276]|Heterozygous||T|A|82|41.0|Non-synonymous|Unprocessed|APF-G1
1521271|IGL00655|2|23400141|I->M||0.1|Benign|0.11|tolerated|MGI:107491|Nxph2|neurexophilin 2 [Source:MGI Symbol;Acc:MGI:107491]|Heterozygous||A|G|46|36.5|Non-synonymous|Unprocessed|APF-G1
1521272|IGL00655|4|49383250|P->L||1.0|Probably damaging||deleterious|MGI:2444345|Acnat2|acyl-coenzyme A amino acid N-acyltransferase 2 [Source:MGI Symbol;Acc:MGI:2444345]|Heterozygous||G|A|44|40.0|Non-synonymous|Unprocessed|APF-G1
1521273|IGL00655|8|9973305|N->K||0.01|Benign|0.21|tolerated|MGI:1335098|Lig4|ligase IV, DNA, ATP-dependent [Source:MGI Symbol;Acc:MGI:1335098]|Heterozygous|Null homozygotes die late in gestation with extensive CNS apoptosis, blocked lymphopoeiesis and failure of V(D)J joining. Carrier fibroblasts show elevated chromosome breaks. ~40% of homozygous hypomorphs survive, with retarded growth, reduced PBL and progressive loss of hematopoietic stem cells.|A|T|25|40.0|Non-synonymous|Unprocessed|APF-G1
1521274|IGL00655|11|57487587|I->F||1.0|Probably damaging||deleterious|MGI:1917629|Fam114a2|family with sequence similarity 114, member A2 [Source:MGI Symbol;Acc:MGI:1917629]|Heterozygous||T|A|21|40.0|Non-synonymous|Unprocessed|APF-G1
1521275|IGL00655|4|106390318|T->A||0.9|Possibly damaging|0.24|tolerated|MGI:1919936|Usp24|ubiquitin specific peptidase 24 [Source:MGI Symbol;Acc:MGI:1919936]|Heterozygous||A|G|21|36.0|Non-synonymous|Unprocessed|APF-G1
1521276|IGL00655|3|27538012|G->R||0.09|Benign|0.51|tolerated|MGI:1919257|Fndc3b|fibronectin type III domain containing 3B [Source:MGI Symbol;Acc:MGI:1919257]|Heterozygous|Mice homozygous for a knock-out allele die shortly after birth despite normal energy homeostasis. Mouse embryonic fibroblasts homozygous for a knock-out allele exhibit impaired adipogenesis and enhanced osteogenesis.|C|T|20|35.0|Non-synonymous|Unprocessed|APF-G1
1521277|IGL00655|6|28421198|R->H||1.0|Probably damaging|0.09|tolerated|MGI:1921625|Gcc1|golgi coiled coil 1 [Source:MGI Symbol;Acc:MGI:1921625]|Heterozygous||C|T|18|39.5|Non-synonymous|Unprocessed|APF-G1
1521278|IGL00655|3|94622784|E->D||0.56|Possibly damaging|0.26|tolerated|MGI:109572|Tuft1|tuftelin 1 [Source:MGI Symbol;Acc:MGI:109572]|Heterozygous||T|A|17|40.0|Non-synonymous|Unprocessed|APF-G1
1521279|IGL00655|7|75704398|K->E||0.99|Probably damaging|0.01|deleterious|MGI:2676556|Akap13|A kinase (PRKA) anchor protein 13 [Source:MGI Symbol;Acc:MGI:2676556]|Heterozygous||A|G|17|40.0|Non-synonymous|Unprocessed|APF-G1
1521280|IGL00655|9|109382244|Disrupted splicing|||N/A|||MGI:3643290|Fbxw22|F-box and WD-40 domain protein 22 [Source:MGI Symbol;Acc:MGI:3643290]|Heterozygous||T|C|40|39.0|Splice|Unprocessed|APF-G1
1521281|IGL00655|3|135231455|Disrupted splicing|||N/A|||MGI:1098230|Cenpe|centromere protein E [Source:MGI Symbol;Acc:MGI:1098230]|Heterozygous|Mice homozygous for a knock-out allele display early embryonic lethality. Mutant embryos grown in culture exhibit inner cell mass growth defects and mitotic chromosome misalignment.|T|C|26|38.5|Splice|Unprocessed|APF-G1
1521282|IGL00655|9|62371712|Disrupted splicing|||N/A|||MGI:108447|Anp32a|acidic (leucine-rich) nuclear phosphoprotein 32 family, member A [Source:MGI Symbol;Acc:MGI:108447]|Heterozygous|Homozygous mutant mice are viable, fertile, behaviorally normal, and show no defects of the central nervous system.|T|A|24|38.0|Splice|Unprocessed|APF-G1
1521796|IGL00656|1|139547755|N->S|||Benign|0.05|deleterious|MGI:2138169|Cfhr1|complement factor H-related 1 [Source:MGI Symbol;Acc:MGI:2138169]|Heterozygous||T|C|85|41.0|Non-synonymous|Unprocessed|APF-G1
1521797|IGL00656|1|156031467|N->S|||Benign|1.0|tolerated|MGI:3582693|Tor1aip1|torsin A interacting protein 1 [Source:MGI Symbol;Acc:MGI:3582693]|Heterozygous||T|C|71|41.0|Non-synonymous|Unprocessed|APF-G1
1521798|IGL00656|5|121795055|I->V|||Benign|||MGI:1277223|Atxn2|ataxin 2 [Source:MGI Symbol;Acc:MGI:1277223]|Heterozygous|Homozygous mice exhibit an enlarged fat pad, hepatic steatosis and enlarged seminal vesicles.  A mild defect in motor learning is seen, but no other notable behavioral or neurological defects are detectable.|A|G|68|38.0|Non-synonymous|Unprocessed|APF-G1
1521799|IGL00656|1|26682901|V->A||0.91|Possibly damaging|0.01|deleterious|MGI:3588222|4931408c20rik|RIKEN cDNA 4931408C20 gene [Source:MGI Symbol;Acc:MGI:3588222]|Heterozygous||A|G|66|39.0|Non-synonymous|Unprocessed|APF-G1
1521800|IGL00656|2|156162871|V->A||1.0|Probably damaging||deleterious|MGI:2157953|Rbm39|RNA binding motif protein 39 [Source:MGI Symbol;Acc:MGI:2157953]|Heterozygous|Homozygous disruption of this locus results in embryonic lethality.|A|G|55|39.0|Non-synonymous|Unprocessed|APF-G1
1521801|IGL00656|5|145372549|I->M||0.59|Possibly damaging|0.04|deleterious|MGI:3646373|Cyp3a57|cytochrome P450, family 3, subfamily a, polypeptide 57 [Source:MGI Symbol;Acc:MGI:3646373]|Heterozygous||A|G|46|40.0|Non-synonymous|Unprocessed|APF-G1
1521802|IGL00656|19|47098170|D->G||1.0|Probably damaging||deleterious|MGI:1341788|Pdcd11|programmed cell death 11 [Source:MGI Symbol;Acc:MGI:1341788]|Heterozygous||A|G|35|38.0|Non-synonymous|Unprocessed|APF-G1
1521803|IGL00656|5|120919207|Y->C||0.83|Possibly damaging|0.06|tolerated|MGI:2140770|Oas1d|2'-5' oligoadenylate synthetase 1D [Source:MGI Symbol;Acc:MGI:2140770]|Heterozygous|Homozygous null females exhibit reduced fertility due to defects in ovarian follicle development and decreased efficiency of ovulation.|A|G|27|37.0|Non-synonymous|Unprocessed|APF-G1
1521804|IGL00656|7|104141777|T->A|||Benign|0.73|tolerated|MGI:3045291|Ubqln3|ubiquilin 3 [Source:MGI Symbol;Acc:MGI:3045291]|Heterozygous||T|C|25|40.0|Non-synonymous|Unprocessed|APF-G1
1521805|IGL00656|9|7581382|T->P||0.8|Possibly damaging|0.07|tolerated|MGI:3039232|Mmp27|matrix metallopeptidase 27 [Source:MGI Symbol;Acc:MGI:3039232]|Heterozygous||A|C|23|40.0|Non-synonymous|Unprocessed|APF-G1
1521806|IGL00656|2|167019966|D->E|||Benign|0.76|tolerated|MGI:2385884|Ddx27|DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 [Source:MGI Symbol;Acc:MGI:2385884]|Heterozygous||T|A|19|40.0|Non-synonymous|Unprocessed|APF-G1
1521807|IGL00656|8|71643147|A->V||0.98|Probably damaging|0.09|tolerated|MGI:3051532|Unc13a|unc-13 homolog A (C. elegans) [Source:MGI Symbol;Acc:MGI:3051532]|Heterozygous||G|A|17|39.0|Non-synonymous|Unprocessed|APF-G1
1521808|IGL00656|6|7680215|Disrupted splicing|||N/A|||MGI:1350929|Asns|asparagine synthetase [Source:MGI Symbol;Acc:MGI:1350929]|Heterozygous||A|T|43|40.0|Splice|Unprocessed|APF-G1
1521809|IGL00656|12|31349595|Disrupted splicing|||N/A|||MGI:107450|Dld|dihydrolipoamide dehydrogenase [Source:MGI Symbol;Acc:MGI:107450]|Heterozygous|Embryos homozygous for a targeted null mutation exhibit a developmental delay at 7.5 days postcoitum and are resorbed by 9.5 days postcoitum.|A|G|42|39.0|Splice|Unprocessed|APF-G1
1521810|IGL00656|9|85717545|Disrupted splicing|||N/A|||MGI:1918677|Ibtk|inhibitor of Bruton agammaglobulinemia tyrosine kinase [Source:MGI Symbol;Acc:MGI:1918677]|Heterozygous||A|G|28|37.0|Splice|Unprocessed|APF-G1
1521811|IGL00656|2|37603138|Disrupted splicing|||N/A|||MGI:104626|Strbp|spermatid perinuclear RNA binding protein [Source:MGI Symbol;Acc:MGI:104626]|Heterozygous|Mice homozygous for a gene trap insertion exhibit premature death, a reduced body size and an abnormal clutching reflex.  Minor brain abnormalities and spermatogenesis defects were also noted.|T|C|20|40.0|Splice|Unprocessed|APF-G1
1521812|IGL00656|7|35206028|Disrupted splicing|||N/A|||MGI:3584516|Lrp3|low density lipoprotein receptor-related protein 3 [Source:MGI Symbol;Acc:MGI:3584516]|Heterozygous||T|C|20|40.0|Splice|Unprocessed|APF-G1
1522841|IGL00658|12|8009471|H->L||0.03|Benign|0.2|tolerated|MGI:88052|Apob|apolipoprotein B [Source:MGI Symbol;Acc:MGI:88052]|Heterozygous|Homozygous null mutants usually die by midgestation and longer survivors exhibit exencephaly. Heterozygotes show reduced plasma cholesterol and apolipoprotein levels. Single isoform B100 and B48 null mutants are viable.|A|T|68|41.0|Non-synonymous|Unprocessed|APF-G1
1522842|IGL00658|9|43113491|I->V||0.01|Benign|0.92|tolerated|MGI:2685030|Tmem136|transmembrane protein 136 [Source:MGI Symbol;Acc:MGI:2685030]|Heterozygous||T|C|60|37.0|Non-synonymous|Unprocessed|APF-G1
1522843|IGL00658|8|43568903|M->L|||Benign|0.17|tolerated|MGI:105985|Adam26a|a disintegrin and metallopeptidase domain 26A (testase 3) [Source:MGI Symbol;Acc:MGI:105985]|Heterozygous||T|A|52|41.0|Non-synonymous|Unprocessed|APF-G1
1522844|IGL00658|2|76897272|H->Y|||Unknown|||MGI:98864|Ttn|titin [Source:MGI Symbol;Acc:MGI:98864]|Heterozygous|Homozygous mutant mice show embryogenesis defects in frontonasal mass, first branchial arch and somites, and vascular, cardiac and skeletal muscle defects causing growth retardation, muscle weakness, abnormal posture, and premature death ranging from embryonic day 11.5 to 8 weeks of age.|G|A|38|36.0|Non-synonymous|Unprocessed|APF-G1
1522845|IGL00658|12|104265170|V->D||0.8|Possibly damaging|0.18|tolerated|MGI:2182841|Serpina3i|serine (or cysteine) peptidase inhibitor, clade A, member 3I [Source:MGI Symbol;Acc:MGI:2182841]|Heterozygous||T|A|36|38.5|Non-synonymous|Unprocessed|APF-G1
1522846|IGL00658|2|66286038|Q->R||0.95|Possibly damaging||deleterious|MGI:98246|Scn1a|sodium channel, voltage-gated, type I, alpha [Source:MGI Symbol;Acc:MGI:98246]|Heterozygous|Mice homozygous for a knock-out allele exhibit postnatal lethality, seizures, and abnormal behavior. Mice heterozygous for a knock-out allele exhibit premature death and seizures associated with abnormal nervous system electrophysiology.|T|C|29|39.0|Non-synonymous|Unprocessed|APF-G1
1522847|IGL00658|5|5625857|D->E||1.0|Probably damaging|0.01|deleterious|MGI:2443778|A330021e22rik|RIKEN cDNA A330021E22 gene [Source:MGI Symbol;Acc:MGI:2443778]|Heterozygous||A|T|27|38.0|Non-synonymous|Unprocessed|APF-G1
1522848|IGL00658|11|104357526|T->I||0.91|Possibly damaging|0.08|tolerated|MGI:1923969|1700081l11rik|RIKEN cDNA 1700081L11 gene [Source:MGI Symbol;Acc:MGI:1923969]|Heterozygous||G|A|25|41.0|Non-synonymous|Unprocessed|APF-G1
1522849|IGL00658|13|50644722|A->S||0.83|Possibly damaging|0.57|tolerated|MGI:2685750|Gm904|predicted gene 904 [Source:MGI Symbol;Acc:MGI:2685750]|Heterozygous||G|T|23|38.0|Non-synonymous|Unprocessed|APF-G1
1522850|IGL00658|17|12615315|D->V||0.12|Benign|0.22|tolerated|MGI:1335072|Slc22a2|solute carrier family 22 (organic cation transporter), member 2 [Source:MGI Symbol;Acc:MGI:1335072]|Heterozygous||A|T|23|37.0|Non-synonymous|Unprocessed|APF-G1
1522851|IGL00658|6|85628961|E->G|||Unknown||deleterious|MGI:1934606|Alms1|Alstrom syndrome 1 homolog (human) [Source:MGI Symbol;Acc:MGI:1934606]|Heterozygous|Homozygous null mice display obesity starting after puberty, hypogonadism, hyperinsulinemia, male-specific hyperglycemia, retinal dysfunction, and late-onset hearing loss.|A|G|21|40.0|Non-synonymous|Unprocessed|APF-G1
1522852|IGL00658|8|105618117|H->Y|||Unknown|1.0|tolerated|MGI:1922937|Fam65a|family with sequence similarity 65, member A [Source:MGI Symbol;Acc:MGI:1922937]|Heterozygous||C|T|18|31.0|Non-synonymous|Unprocessed|APF-G1
1522853|IGL00658|8|54156948|Disrupted splicing|||N/A|||MGI:109124|Vegfc|vascular endothelial growth factor C [Source:MGI Symbol;Acc:MGI:109124]|Heterozygous|Mutation of this gene affects the development of the lymphatic system. Homozygous inactivation is embryonic lethal.|T|C|25|37.0|Splice|Unprocessed|APF-G1
1523329|IGL00659|2|127063301|V->A||0.36|Benign|0.87|tolerated|MGI:1336993|Ap4e1|adaptor-related protein complex AP-4, epsilon 1 [Source:MGI Symbol;Acc:MGI:1336993]|Heterozygous||T|C|104|39.0|Non-synonymous|Unprocessed|APF-G1
1523330|IGL00659|8|86861802|D->E||1.0|Probably damaging||deleterious|MGI:2136825|N4bp1|NEDD4 binding protein 1 [Source:MGI Symbol;Acc:MGI:2136825]|Heterozygous||G|T|66|40.0|Non-synonymous|Unprocessed|APF-G1
1523331|IGL00659|4|139421245|T->I|||Unknown||deleterious|MGI:1916366|Ubr4|ubiquitin protein ligase E3 component n-recognin 4 [Source:MGI Symbol;Acc:MGI:1916366]|Heterozygous||C|T|60|40.0|Non-synonymous|Unprocessed|APF-G1
1523332|IGL00659|3|83070673|S->T||0.98|Probably damaging|0.03|deleterious|MGI:1858197|Plrg1|pleiotropic regulator 1, PRL1 homolog (Arabidopsis) [Source:MGI Symbol;Acc:MGI:1858197]|Heterozygous|Mice homozygous for a knock-out allele exhibit embryonic lethality by E1.5.|T|A|48|37.0|Non-synonymous|Unprocessed|APF-G1
1523333|IGL00659|5|145007246|I->F||0.99|Probably damaging||deleterious|MGI:2141165|Kpna7|karyopherin alpha 7 (importin alpha 8) [Source:MGI Symbol;Acc:MGI:2141165]|Heterozygous||T|A|45|40.0|Non-synonymous|Unprocessed|APF-G1
1523334|IGL00659|3|129836813|K->E|||Unknown|0.04|deleterious|MGI:105937|Cfi|complement component factor i [Source:MGI Symbol;Acc:MGI:105937]|Heterozygous|Homozygous null mice display uncontrolled alternative pathway activation as shown by reduced complement C3, factor B, and factor H levels, but do not develop C3 deposition along the glomerular basement membrane or membranoproliferative glomerulonephritis type II. Plasma C3 circulates as C3b.|A|G|37|37.0|Non-synonymous|Unprocessed|APF-G1
1523335|IGL00659|7|26557625|I->V||0.03|Benign|0.23|tolerated|MGI:2675292|Nlrp9a|NLR family, pyrin domain containing 9A [Source:MGI Symbol;Acc:MGI:2675292]|Heterozygous||A|G|31|39.0|Non-synonymous|Unprocessed|APF-G1
1523336|IGL00659|7|6962282|N->D||0.99|Probably damaging|0.04|deleterious|MGI:1888998|Usp29|ubiquitin specific peptidase 29 [Source:MGI Symbol;Acc:MGI:1888998]|Heterozygous||A|G|29|40.0|Non-synonymous|Unprocessed|APF-G1
1523337|IGL00659|8|119312667|D->G||1.0|Probably damaging|1.0|tolerated|MGI:99551|Cdh13|cadherin 13 [Source:MGI Symbol;Acc:MGI:99551]|Heterozygous|Mice homozygous for a null allele exhibit decreased retinal neovascularization and increased adiponectin levels.|A|G|26|37.0|Non-synonymous|Unprocessed|APF-G1
1523338|IGL00659|10|117702299|R->G||0.04|Benign|0.01|deleterious|MGI:96952|Mdm2|transformed mouse 3T3 cell double minute 2 [Source:MGI Symbol;Acc:MGI:96952]|Heterozygous|Mice homozygous for a gene trapped allele exhibit embryonic lethality.  Mice homozygous for a null allele exhibit prenatal lethality. Mice homozygous for one knock-in allele exhibit embryonic lethality while mice homozygous for a different knock-in allele exhibit alters cell cycle regulation.|T|C|21|39.0|Non-synonymous|Unprocessed|APF-G1
1523339|IGL00659|10|128570983|S->P|||Benign|0.27|tolerated|MGI:95411|Erbb3|v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) [Source:MGI Symbol;Acc:MGI:95411]|Heterozygous|Homozygotes for targeted null mutations exhibit a lack of Schwann-cell precursors leading to loss of sensory and motor neurons, hypoplasia of the primary sympathetic ganglion chain, cardiac defects, impaired brain development, and embryonic lethality.|A|G|19|38.0|Non-synonymous|Unprocessed|APF-G1
1523340|IGL00659|11|69640250|Q->K||0.01|Benign|0.32|tolerated|MGI:1346074|Fxr2|fragile X mental retardation, autosomal homolog 2 [Source:MGI Symbol;Acc:MGI:1346074]|Heterozygous|Homozygotes for a targeted null mutation exhibit hyperactivity, impaired Morris water task performance, and reductions in prepulse inhibition, contextual conditioned fear, and sensitivity to heat stimulus.|C|A|19|38.0|Non-synonymous|Unprocessed|APF-G1
1523341|IGL00659|17|74660653|V->E||0.08|Benign||deleterious|MGI:1276108|Birc6|baculoviral IAP repeat-containing 6 [Source:MGI Symbol;Acc:MGI:1276108]|Heterozygous|Homozygous mice exhibit perinatal lethality and exhibit placental defects.|T|A|18|40.0|Non-synonymous|Unprocessed|APF-G1
1523342|IGL00659|6|116626505|Q->Stop|||N/A|||MGI:1914505|Zfp422|zinc finger protein 422 [Source:MGI Symbol;Acc:MGI:1914505]|Heterozygous||G|A|17|41.0|Non-synonymous|Unprocessed|APF-G1
1523343|IGL00659|10|82227521|Disrupted splicing|||N/A|||MGI:3621440|Zfp938|zinc finger protein 938 [Source:MGI Symbol;Acc:MGI:3621440]|Heterozygous||T|A|148|41.0|Splice|Unprocessed|APF-G1
1523344|IGL00659|10|83191805|Disrupted splicing|||N/A|||MGI:1927166|Chst11|carbohydrate sulfotransferase 11 [Source:MGI Symbol;Acc:MGI:1927166]|Heterozygous|Mice homozygous for a null allele exhibit neonatal lethality associated with respiratory distress, dwarfism, and abnormal skeletal structures.|T|G|68|34.0|Splice|Unprocessed|APF-G1
1523345|IGL00659|9|36722599|Disrupted splicing|||N/A|||MGI:1202065|Chek1|checkpoint kinase 1 homolog (S. pombe) [Source:MGI Symbol;Acc:MGI:1202065]|Heterozygous|Mice homozygous for disruptions in this gene display embryonic lethality between E2.5 and E7.5, impaired cell cycle checkpoint function, increase in blastocyst apoptosis and lack of inner cell mass proliferation.|C|A|62|40.0|Splice|Unprocessed|APF-G1
1523346|IGL00659|8|33322377|Disrupted splicing|||N/A|||MGI:109635|Wrn|Werner syndrome homolog (human) [Source:MGI Symbol;Acc:MGI:109635]|Heterozygous|Homozygous mutants show enhanced frequency and variety of tumors in conjunction with Trp53 knockout alleles. Homozygotes also have an elevated frequency of somatic reversion of the pink-eyed dilution unstable mutation.|A|G|50|39.5|Splice|Unprocessed|APF-G1
1523347|IGL00659|4|62333680|Disrupted splicing|||N/A|||MGI:2444782|Fkbp15|FK506 binding protein 15 [Source:MGI Symbol;Acc:MGI:2444782]|Heterozygous||T|C|49|39.0|Splice|Unprocessed|APF-G1
1523348|IGL00659|13|112966635|Disrupted splicing|||N/A|||MGI:2145374|Dhx29|DEAH (Asp-Glu-Ala-His) box polypeptide 29 [Source:MGI Symbol;Acc:MGI:2145374]|Heterozygous||A|G|48|39.0|Splice|Unprocessed|APF-G1
1523349|IGL00659|2|144583770|Disrupted splicing|||N/A|||MGI:1350925|Sec23b|SEC23B (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1350925]|Heterozygous||T|C|46|39.0|Splice|Unprocessed|APF-G1
1523350|IGL00659|4|104801334|Disrupted splicing|||N/A|||MGI:88236|C8b|complement component 8, beta polypeptide [Source:MGI Symbol;Acc:MGI:88236]|Heterozygous|In a controlled microbial environment (clean) laboratory, mice homozygous for an inactivating mutation of this gene are viable and fertile and exhibit no apparent abonormal phenotype.|T|A|45|38.0|Splice|Unprocessed|APF-G1
1523351|IGL00659|2|129118100|Disrupted splicing|||N/A|||MGI:108014|Polr1b|polymerase (RNA) I polypeptide B [Source:MGI Symbol;Acc:MGI:108014]|Heterozygous|Mice homozygous for a gene trapped allele exhibit embryonic lethality prior to implantation.|T|C|16|39.5|Splice|Unprocessed|APF-G1
1523892|IGL00660|1|44206370|K->E||0.69|Possibly damaging|0.01|deleterious|MGI:3526905, MGI:3526906, MGI:3531331, MGI:3042876, MGI:3526902, MGI:3526946, MGI:3526904, MGI:3526903, MGI:3042883, MGI:3772854, MGI:3512165, MGI:3042878, MGI:2685837|4832428d23rik|RIKEN cDNA 4832428D23 gene [Source:MGI Symbol;Acc:MGI:2685837]|Heterozygous||T|C|76|40.0|Non-synonymous|Unprocessed|APF-G1
1523893|IGL00660|13|94390863|V->D||0.99|Probably damaging||deleterious|MGI:1333879|Ap3b1|adaptor-related protein complex 3, beta 1 subunit [Source:MGI Symbol;Acc:MGI:1333879]|Heterozygous|Homozygous mutants exhibit hypopigmentation, elevated kidney levels of lysosomal enzymes, platelet storage pool deficiency, reduced ipsilateral projections from the retina to brain, reduced sensitivity of dark-adapted retina and shortened life span.|T|A|74|39.0|Non-synonymous|Unprocessed|APF-G1
1523894|IGL00660|3|116546295|I->T||0.99|Probably damaging||deleterious|MGI:105386|Dbt|dihydrolipoamide branched chain transacylase E2 [Source:MGI Symbol;Acc:MGI:105386]|Heterozygous|Homozygous mutation of this gene results in postnatal lethality, pallor, respiratory distress, and an increase in branched-chain amino acids in the blood and urine. Homozygotes model Maple Syrup Urine Disease.|T|C|44|39.0|Non-synonymous|Unprocessed|APF-G1
1523895|IGL00660|10|53622973|L->Q||0.01|Benign|0.31|tolerated|MGI:1918817|Mcm9|minichromosome maintenance complex component 9 [Source:MGI Symbol;Acc:MGI:1918817]|Heterozygous||A|T|41|39.0|Non-synonymous|Unprocessed|APF-G1
1523896|IGL00660|7|24275692|K->N||1.0|Probably damaging||deleterious|MGI:107611|Zfp93|zinc finger protein 93 [Source:MGI Symbol;Acc:MGI:107611]|Heterozygous||G|T|40|37.0|Non-synonymous|Unprocessed|APF-G1
1523897|IGL00660|9|62875492|K->R|||Benign|1.0|tolerated|MGI:1922850|Calml4|calmodulin-like 4 [Source:MGI Symbol;Acc:MGI:1922850]|Heterozygous||A|G|39|40.0|Non-synonymous|Unprocessed|APF-G1
1523898|IGL00660|3|50427687|I->V|||Benign|0.77|tolerated|MGI:1347355|Slc7a11|solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 [Source:MGI Symbol;Acc:MGI:1347355]|Heterozygous|Homozygous mutant mice show a reduction in yellow pigment resulting in dilution of agouti; only pinna hairs are affected in nonagouti mice. Mice homozygous for an ENU-induced allele exhibit decreased survival of LPS-induced macrophages and increased incidence of chemically-induced tumors.|T|C|28|39.0|Non-synonymous|Unprocessed|APF-G1
1523899|IGL00660|2|115776985|A->V||0.01|Benign|0.01|deleterious|MGI:3026886|Bc052040|cDNA sequence BC052040 [Source:MGI Symbol;Acc:MGI:3026886]|Heterozygous||C|T|19|38.0|Non-synonymous|Unprocessed|APF-G1
1523900|IGL00660|9|7075797|M->I||0.83|Possibly damaging|0.02|deleterious|MGI:107736|Dync2h1|dynein cytoplasmic 2 heavy chain 1 [Source:MGI Symbol;Acc:MGI:107736]|Heterozygous|Mice homozygous for a gene trap allele exhibit embryonic lethality at E12.5 with altered heart looping.  Mice homozygous for one ENU-induced mutations exhibit embryonic lethality and altered left-right axis patterning.|C|T|19|38.0|Non-synonymous|Unprocessed|APF-G1
1523901|IGL00660|1|149886203|N->D||0.01|Benign|0.05|deleterious|MGI:1195256|Pla2g4a|phospholipase A2, group IVA (cytosolic, calcium-dependent) [Source:MGI Symbol;Acc:MGI:1195256]|Heterozygous|Mice homozygouse for disruptions in this gene display reduced allergic and autoimmune reactions.  They also display an increased incidence of insulin and reduced female reproductive performance.|T|C|18|39.0|Non-synonymous|Unprocessed|APF-G1
1523902|IGL00660|7|100639249|Disrupted splicing|||N/A|||MGI:894313|Rab6|RAB6, member RAS oncogene family [Source:MGI Symbol;Acc:MGI:894313]|Heterozygous||T|C|69|39.0|Splice|Unprocessed|APF-G1
1523903|IGL00660|2|174465805|Disrupted splicing|||N/A|||MGI:1913640|Slmo2|slowmo homolog 2 (Drosophila) [Source:MGI Symbol;Acc:MGI:1913640]|Heterozygous||T|C|45|36.0|Splice|Unprocessed|APF-G1
1523904|IGL00660|5|76854933|Disrupted splicing|||N/A|||MGI:2444817|C530008m17rik|RIKEN cDNA C530008M17 gene [Source:MGI Symbol;Acc:MGI:2444817]|Heterozygous||A|T|25|35.0|Splice|Unprocessed|APF-G1
1523905|IGL00660|4|59737743|Disrupted splicing|||N/A|||MGI:2442164|E130308a19rik|RIKEN cDNA E130308A19 gene [Source:MGI Symbol;Acc:MGI:2442164]|Heterozygous||C|T|16|40.0|Splice|Unprocessed|APF-G1
1524418|IGL00661|11|79999092|V->E||0.01|Benign|0.1|tolerated|MGI:1261758|Suz12|suppressor of zeste 12 homolog (Drosophila) [Source:MGI Symbol;Acc:MGI:1261758]|Heterozygous|Homozygous null mice die during early postimplantation stages with failure of embryonic and extraembyronic tissues and organogenesis.  Mice heterozygous for a knock-out allele exhibit abnormal brain and spinal cord development with varying penetrance.|T|A|85|40.0|Non-synonymous|Unprocessed|APF-G1
1524419|IGL00661|6|97176494|V->A|||Benign|0.77|tolerated|MGI:2684999|Tmf1|TATA element modulatory factor 1 [Source:MGI Symbol;Acc:MGI:2684999]|Heterozygous||A|G|75|39.0|Non-synonymous|Unprocessed|APF-G1
1524420|IGL00661|5|98004296|D->G||0.76|Possibly damaging|0.27|tolerated|MGI:1919164|Antxr2|anthrax toxin receptor 2 [Source:MGI Symbol;Acc:MGI:1919164]|Heterozygous|Mice homozygous for a null mutation display femaly infertility and are highly resistant to Bacillus anthracis or anthrax toxin induced lethality.|T|C|65|38.0|Non-synonymous|Unprocessed|APF-G1
1524421|IGL00661|6|41462619|K->N||0.35|Benign|0.56|tolerated|MGI:98839|Prss1|protease, serine, 1 (trypsin 1) [Source:MGI Symbol;Acc:MGI:98839]|Heterozygous||G|T|58|38.0|Non-synonymous|Unprocessed|APF-G1
1524422|IGL00661|8|69073731|W->R|||Benign|0.35|tolerated|MGI:106684|Slc18a1|solute carrier family 18 (vesicular monoamine), member 1 [Source:MGI Symbol;Acc:MGI:106684]|Heterozygous|Mice homozygous for disruptions in this gene display a normal phenotype.|A|T|51|40.0|Non-synonymous|Unprocessed|APF-G1
1524423|IGL00661|12|101588098|T->S||0.94|Possibly damaging|0.02|deleterious|MGI:2443988|Catsperb|cation channel, sperm-associated, beta [Source:MGI Symbol;Acc:MGI:2443988]|Heterozygous||A|T|50|39.0|Non-synonymous|Unprocessed|APF-G1
1524424|IGL00661|4|144703693|V->A||0.83|Possibly damaging|0.05|deleterious|MGI:3650721|Gm13178|predicted gene 13178 [Source:MGI Symbol;Acc:MGI:3650721]|Heterozygous||A|G|43|39.0|Non-synonymous|Unprocessed|APF-G1
1524425|IGL00661|8|79281570|R->C||0.74|Possibly damaging|0.16|tolerated|MGI:1923805|Mmaa|methylmalonic aciduria (cobalamin deficiency) type A [Source:MGI Symbol;Acc:MGI:1923805]|Heterozygous||G|A|39|37.0|Non-synonymous|Unprocessed|APF-G1
1524426|IGL00661|17|88750118|A->V|||Benign|0.34|tolerated|MGI:96783|Lhcgr|luteinizing hormone/choriogonadotropin receptor [Source:MGI Symbol;Acc:MGI:96783]|Heterozygous|Homozygous null mutants are infertile and have abnormal hormone levels. Males have undescended testes, immature external and accessory sex organs and blocked spermatogenesis. Females have small ovaries and uteri, immature follicles and do not cycle.|G|A|37|38.0|Non-synonymous|Unprocessed|APF-G1
1524427|IGL00661|15|89427591|R->S|||Benign|0.88|tolerated|MGI:1328313|Chkb|choline kinase beta [Source:MGI Symbol;Acc:MGI:1328313]|Heterozygous|Homozygous null mice display progressive muscular weakness and dystrophy in the hindlimbs but have normal nerve and neuromuscular junction morphology.|T|A|36|38.5|Non-synonymous|Unprocessed|APF-G1
1524428|IGL00661|3|135858112|K->N||0.01|Benign|0.39|tolerated|MGI:1914797|Slc39a8|solute carrier family 39 (metal ion transporter), member 8 [Source:MGI Symbol;Acc:MGI:1914797]|Heterozygous||A|C|35|38.0|Non-synonymous|Unprocessed|APF-G1
1524429|IGL00661|5|86081273|H->R||0.01|Benign|0.34|tolerated|MGI:1926193|Stap1|signal transducing adaptor family member 1 [Source:MGI Symbol;Acc:MGI:1926193]|Heterozygous||A|G|32|39.5|Non-synonymous|Unprocessed|APF-G1
1524430|IGL00661|13|23250084|S->P||0.97|Probably damaging|0.19|tolerated|MGI:3649245|Vmn1r223|vomeronasal 1 receptor 223 [Source:MGI Symbol;Acc:MGI:3649245]|Heterozygous||T|C|30|36.5|Non-synonymous|Unprocessed|APF-G1
1524431|IGL00661|17|84649240|D->V||0.71|Possibly damaging|0.01|deleterious|MGI:1913996|Dync2li1|dynein cytoplasmic 2 light intermediate chain 1 [Source:MGI Symbol;Acc:MGI:1913996]|Heterozygous|Mice homozygous for disruptions in this allele die before embryonic day 11.5.  They display neural tube defects in addition to a variety developmental patterning abnormalities.|A|T|26|38.5|Non-synonymous|Unprocessed|APF-G1
1524432|IGL00661|7|19616411|V->A||0.96|Probably damaging|0.05|tolerated|MGI:103289|Relb|avian reticuloendotheliosis viral (v-rel) oncogene related B [Source:MGI Symbol;Acc:MGI:103289]|Heterozygous|Homozygotes for targeted and insertional null mutations exhibit inflammatory cell infiltration of organs, myeloid hyperplasia, splenomegaly, reduction in thymic dendritic cells, impaired cellular immunity, hyperkeratosis, and epidermal hyperplasia.|A|G|26|39.0|Non-synonymous|Unprocessed|APF-G1
1524433|IGL00661|11|76965932|K->Stop|||N/A|||MGI:1345186|Blmh|bleomycin hydrolase [Source:MGI Symbol;Acc:MGI:1345186]|Heterozygous|About one-third of homozygous null mutants die neonatally; survivors develop variably penetrant tail dermatitis and pulmonary fibrosis following bleomycin treatment.|A|T|25|38.0|Non-synonymous|Unprocessed|APF-G1
1524434|IGL00661|7|129316299|I->N||0.4|Benign|0.03|deleterious|MGI:2685936|Ppapdc1a|phosphatidic acid phosphatase type 2 domain containing 1A [Source:MGI Symbol;Acc:MGI:2685936]|Heterozygous||T|A|23|35.0|Non-synonymous|Unprocessed|APF-G1
1524435|IGL00661|2|132870668|V->I||0.24|Benign|0.39|tolerated|MGI:2445154|Lrrn4|leucine rich repeat neuronal 4 [Source:MGI Symbol;Acc:MGI:2445154]|Heterozygous||C|T|20|36.5|Non-synonymous|Unprocessed|APF-G1
1524436|IGL00661|7|138898072|P->L||0.04|Benign|0.13|tolerated|MGI:109326|Bnip3|BCL2/adenovirus E1B interacting protein 3 [Source:MGI Symbol;Acc:MGI:109326]|Heterozygous|Mice homozygous for a null allele exhibit decreased post-ischemic ventricular remodeling.|G|A|20|38.0|Non-synonymous|Unprocessed|APF-G1
1524437|IGL00661|11|69357383|K->N||0.99|Probably damaging|0.04|deleterious|MGI:1344395|Chd3|chromodomain helicase DNA binding protein 3 [Source:MGI Symbol;Acc:MGI:1344395]|Heterozygous||C|A|19|40.0|Non-synonymous|Unprocessed|APF-G1
1524438|IGL00661|13|28021376|V->A||0.04|Benign|0.31|tolerated|MGI:1206587|Prl4a1|prolactin family 4, subfamily a, member 1 [Source:MGI Symbol;Acc:MGI:1206587]|Heterozygous|Female mice homozygous for a knock-out allele are unable to adapt to hypobaric hypoxia during gestation, resulting in pregnancy failure.|T|C|18|38.0|Non-synonymous|Unprocessed|APF-G1
1524439|IGL00661|5|12505839|S->P||1.0|Probably damaging|0.02|deleterious|MGI:1860118|Sema3d|sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D [Source:MGI Symbol;Acc:MGI:1860118]|Heterozygous||T|C|17|38.0|Non-synonymous|Unprocessed|APF-G1
1524440|IGL00661|8|25972937|V->M||0.45|Possibly damaging|0.22|tolerated|MGI:1196297|Hgsnat|heparan-alpha-glucosaminide N-acetyltransferase [Source:MGI Symbol;Acc:MGI:1196297]|Heterozygous||C|T|17|39.0|Non-synonymous|Unprocessed|APF-G1
1524441|IGL00661|7|109908372|N->S|||Benign|0.86|tolerated|MGI:1201681|Dennd5a|DENN/MADD domain containing 5A [Source:MGI Symbol;Acc:MGI:1201681]|Heterozygous||T|C|16|39.0|Non-synonymous|Unprocessed|APF-G1
1524442|IGL00661|2|140419904|Disrupted splicing|||N/A|||MGI:1920149|Macrod2|MACRO domain containing 2 [Source:MGI Symbol;Acc:MGI:1920149]|Heterozygous||G|A|144|40.0|Splice|Unprocessed|APF-G1
1524443|IGL00661|8|33319145|Disrupted splicing|||N/A|||MGI:109635|Wrn|Werner syndrome homolog (human) [Source:MGI Symbol;Acc:MGI:109635]|Heterozygous|Homozygous mutants show enhanced frequency and variety of tumors in conjunction with Trp53 knockout alleles. Homozygotes also have an elevated frequency of somatic reversion of the pink-eyed dilution unstable mutation.|T|A|140|38.0|Splice|Unprocessed|APF-G1
1524444|IGL00661|11|62837232|Disrupted splicing|||N/A|||MGI:2137356|Trim16|tripartite motif-containing 16 [Source:MGI Symbol;Acc:MGI:2137356]|Heterozygous||T|A|38|40.5|Splice|Unprocessed|APF-G1
1524445|IGL00661|13|74674789|Disrupted splicing|||N/A|||MGI:1933403|Erap1|endoplasmic reticulum aminopeptidase 1 [Source:MGI Symbol;Acc:MGI:1933403]|Heterozygous|Mice homozygous for a targeted mutation may exhibit extramedullary hematopoiesis of the spleen, thymus hyperplasia, or enlarged kidneys at older ages.|T|C|37|40.0|Splice|Unprocessed|APF-G1
1524446|IGL00661|11|52000292|Disrupted splicing|||N/A|||MGI:102944|Ube2b|ubiquitin-conjugating enzyme E2B, RAD6 homology (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:102944]|Heterozygous|Homozygous null mutants exhibit male sterility with failure at the stage of postmeiotic condensation of chromatin in spermatids. However, in 10-20% of males there is a nearly complete absence of all germ cell types.|C|T|32|38.0|Splice|Unprocessed|APF-G1
1524447|IGL00661|4|101652476|Disrupted splicing|||N/A|||MGI:2687005|Leprot|leptin receptor overlapping transcript [Source:MGI Symbol;Acc:MGI:2687005]|Heterozygous||T|C|28|39.5|Splice|Unprocessed|APF-G1
1524448|IGL00661|9|96577553|Disrupted splicing|||N/A|||MGI:2149960|Rasa2|RAS p21 protein activator 2 [Source:MGI Symbol;Acc:MGI:2149960]|Heterozygous||C|T|24|40.0|Splice|Unprocessed|APF-G1
1524938|IGL00662|19|16704540|K->I||0.87|Possibly damaging|0.02|deleterious|MGI:2444304|Vps13a|vacuolar protein sorting 13A (yeast) [Source:MGI Symbol;Acc:MGI:2444304]|Heterozygous|Aging mice homozygous for a knock-out allele display motor dysfunction and abnormal social interaction, hematologic anomalies including acanthocytosis, selective atrophy of the striatum with significant apoptosis and gliosis, and reduced homovanillic acid levels in midbrain.|T|A|206|39.0|Non-synonymous|Unprocessed|APF-G1
1524939|IGL00662|10|12664961|E->K||1.0|Probably damaging|0.08|tolerated|MGI:104631|Utrn|utrophin [Source:MGI Symbol;Acc:MGI:104631]|Heterozygous|Homozygous null mutants have reduced density of acetylcholine receptors and reduced number of junctional folds at neuromuscular junctions. Mice homozygous for utrophin and dystrophin knockouts die prematurely with severe, progressive muscular dystrophy.|C|T|158|40.0|Non-synonymous|Unprocessed|APF-G1
1524940|IGL00662|19|44097210|F->I||0.22|Benign|0.09|tolerated|MGI:99484|Chuk|conserved helix-loop-helix ubiquitous kinase [Source:MGI Symbol;Acc:MGI:99484]|Heterozygous|Homozygotes for targeted null mutations die neonataly and exhibit thickened, taut, adhesive skin that prevents appendages from protruding from the trunk, absence of whiskers, skeletal abnormalities, and closed esophagus.|A|T|73|39.0|Non-synonymous|Unprocessed|APF-G1
1524941|IGL00662|9|15996427|I->F||0.41|Benign|0.01|deleterious|MGI:2444314|Fat3|FAT tumor suppressor homolog 3 (Drosophila) [Source:MGI Symbol;Acc:MGI:2444314]|Heterozygous||T|A|57|39.0|Non-synonymous|Unprocessed|APF-G1
1524942|IGL00662|1|187117339|N->S|||Benign|0.51|tolerated|MGI:1921967|Spata17|spermatogenesis associated 17 [Source:MGI Symbol;Acc:MGI:1921967]|Heterozygous||T|C|53|37.0|Non-synonymous|Unprocessed|APF-G1
1524943|IGL00662|13|60798942|S->P||0.88|Possibly damaging|0.12|tolerated|MGI:1917452|Ctsll3|cathepsin L-like 3 [Source:MGI Symbol;Acc:MGI:1917452]|Heterozygous||A|G|51|39.0|Non-synonymous|Unprocessed|APF-G1
1524944|IGL00662|9|40211043|N->S|||Benign|1.0|tolerated|MGI:1933401|Zfp202|zinc finger protein 202 [Source:MGI Symbol;Acc:MGI:1933401]|Heterozygous||A|G|51|39.0|Non-synonymous|Unprocessed|APF-G1
1524945|IGL00662|5|45693160|S->T|||Benign|0.19|tolerated|MGI:1930197|Ncapg|non-SMC condensin I complex, subunit G [Source:MGI Symbol;Acc:MGI:1930197]|Heterozygous||T|A|49|38.0|Non-synonymous|Unprocessed|APF-G1
1524946|IGL00662|1|125587424|L->H||1.0|Probably damaging||deleterious|MGI:1921400|Slc35f5|solute carrier family 35, member F5 [Source:MGI Symbol;Acc:MGI:1921400]|Heterozygous||T|A|48|37.0|Non-synonymous|Unprocessed|APF-G1
1524947|IGL00662|8|40905622|Y->C||1.0|Probably damaging|0.01|deleterious|MGI:99828|Slc7a2|solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 [Source:MGI Symbol;Acc:MGI:99828]|Heterozygous|Homozygotes for a targeted null allele exhibit a marked reduction of nitric oxide production by cytokine-activated macrophages.|A|G|41|35.0|Non-synonymous|Unprocessed|APF-G1
1524948|IGL00662|6|29565846|L->Stop|||N/A|||MGI:1196412|Tnpo3|transportin 3 [Source:MGI Symbol;Acc:MGI:1196412]|Heterozygous||A|T|33|40.0|Non-synonymous|Unprocessed|APF-G1
1524949|IGL00662|6|83675926|I->T||0.81|Possibly damaging|0.04|deleterious|MGI:2180021|Cd207|CD207 antigen [Source:MGI Symbol;Acc:MGI:2180021]|Heterozygous||A|G|31|40.0|Non-synonymous|Unprocessed|APF-G1
1524950|IGL00662|1|57956738|T->A||1.0|Probably damaging||deleterious|MGI:3603813|Kctd18|potassium channel tetramerisation domain containing 18 [Source:MGI Symbol;Acc:MGI:3603813]|Heterozygous||T|C|29|39.0|Non-synonymous|Unprocessed|APF-G1
1524951|IGL00662|1|40541921|R->C||0.99|Probably damaging|0.2|tolerated|MGI:1338888|Il18rap|interleukin 18 receptor accessory protein [Source:MGI Symbol;Acc:MGI:1338888]|Heterozygous|Homozygous null mice exhibit defective IL-18-mediated immune responses such as the inability of splenocytes, T helper 1 cells and neutrophils to produce cytokines in response to IL-18.|C|T|27|40.0|Non-synonymous|Unprocessed|APF-G1
1524952|IGL00662|7|102194987|N->I||1.0|Probably damaging|0.04|deleterious|MGI:109404|Nup98|nucleoporin 98 [Source:MGI Symbol;Acc:MGI:109404]|Heterozygous|Homozygotes for a null allele die in utero with a severe growth delay and improper gastrulation and nuclear pore complex assembly/function. Heterozygotes for another null allele show impaired IFN-mediated responses, reduced T and B cell subsets in lymphoid organs and altered T and B cell functions.|T|A|27|39.0|Non-synonymous|Unprocessed|APF-G1
1524953|IGL00662|7|101289896|N->S|||Benign|1.0|tolerated|MGI:1920933|Atg16l2|autophagy related 16 like 2 (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1920933]|Heterozygous||T|C|26|35.5|Non-synonymous|Unprocessed|APF-G1
1524954|IGL00662|15|72546075|S->P||0.98|Probably damaging|0.04|deleterious|MGI:3521816|Kcnk9|potassium channel, subfamily K, member 9 [Source:MGI Symbol;Acc:MGI:3521816]|Heterozygous||A|G|20|38.0|Non-synonymous|Unprocessed|APF-G1
1524955|IGL00662|16|57303729|D->G||0.95|Possibly damaging|0.06|tolerated|MGI:1913747|2610528e23rik|RIKEN cDNA 2610528E23 gene [Source:MGI Symbol;Acc:MGI:1913747]|Heterozygous||T|C|20|39.5|Non-synonymous|Unprocessed|APF-G1
1524956|IGL00662|15|10490409|N->S||0.25|Benign|0.23|tolerated|MGI:1316678|Rad1|RAD1 homolog (S. pombe) [Source:MGI Symbol;Acc:MGI:1316678]|Heterozygous|Mice homozygous for a knock-in allele exhibit normal B cell DNA damage sensitivity, somatic hypermutation, and class switch recombination.|A|G|19|38.0|Non-synonymous|Unprocessed|APF-G1
1524957|IGL00662|6|87902370|T->I||0.9|Possibly damaging|0.02|deleterious|MGI:1858696|Copg|coatomer protein complex, subunit gamma [Source:MGI Symbol;Acc:MGI:1858696]|Heterozygous||C|T|19|35.0|Non-synonymous|Unprocessed|APF-G1
1524958|IGL00662|2|172551518|Y->H||0.63|Possibly damaging|0.12|tolerated|MGI:106032|Tcfap2c|transcription factor AP-2, gamma [Source:MGI Symbol;Acc:MGI:106032]|Heterozygous||T|C|16|30.5|Non-synonymous|Unprocessed|APF-G1
1524959|IGL00662|3|122512936|A->V|||Benign|1.0|tolerated|MGI:1352501|Bcar3|breast cancer anti-estrogen resistance 3 [Source:MGI Symbol;Acc:MGI:1352501]|Heterozygous|Mice homozygous for a knock-out allele exhibit cataracts due to rupture of the lens capsule and liquefaction of lens cortical fibers.|C|T|16|36.5|Non-synonymous|Unprocessed|APF-G1
1524960|IGL00662|3|109528392|Disrupted splicing|||N/A|||MGI:1888518|Vav3|vav 3 oncogene [Source:MGI Symbol;Acc:MGI:1888518]|Heterozygous|Homozygous mutation of this gene results in tachycardia, systemic arterial hypertension, cardiovascular remodeling, hyperactivity of sympathetic neurons and thus high catecholamine levels, and increased levels of kidney-related hormones.|T|A|179|39.0|Splice|Unprocessed|APF-G1
1524961|IGL00662|10|75168100|Disrupted splicing|||N/A|||MGI:88141|Bcr|breakpoint cluster region [Source:MGI Symbol;Acc:MGI:88141]|Heterozygous|Homozygous null mutants are defective in hormonal and behavioral stress response regulation and prone to septic shock, whereas chimeric mice carrying a BCR-ABL fusion mutation mimicking human Philadelphia chromosome develop chronic myeloid leukemia.|A|T|52|39.0|Splice|Unprocessed|APF-G1
1524962|IGL00662|8|116928587|Disrupted splicing|||N/A|||MGI:1919405|Cenpn|centromere protein N [Source:MGI Symbol;Acc:MGI:1919405]|Heterozygous||T|C|34|39.0|Splice|Unprocessed|APF-G1
1524963|IGL00662|5|30929675|Disrupted splicing|||N/A|||MGI:1096353|Khk|ketohexokinase [Source:MGI Symbol;Acc:MGI:1096353]|Heterozygous|Mice homozygous for alleles that do not produce isoform A or isoforms A and C exhibit normal fertility, development, blood chemistry, and tissue metabolite levels.|T|C|26|38.0|Splice|Unprocessed|APF-G1
1524964|IGL00662|4|40220389|Disrupted splicing|||N/A|||MGI:2442858|Ddx58|DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 [Source:MGI Symbol;Acc:MGI:2442858]|Heterozygous||A|G|19|40.0|Splice|Unprocessed|APF-G1
1524965|IGL00662|7|34215950|Disrupted splicing|||N/A|||MGI:95797|Gpi1|glucose phosphate isomerase 1 [Source:MGI Symbol;Acc:MGI:95797]|Heterozygous|Homozygotes for null mutations fail to develop beyond the egg cylinder stage and die by embryonic day 9.5. Homozygotes for a hypomorphic mutation exhibit nonspherocytic hemolytic anemia with hepatosplenomegaly.|A|G|19|37.0|Splice|Unprocessed|APF-G1
1525512|IGL00663|8|90983490|Y->C|||Unknown||deleterious|MGI:1924001|Chd9|chromodomain helicase DNA binding protein 9 [Source:MGI Symbol;Acc:MGI:1924001]|Heterozygous||A|G|149|40.0|Non-synonymous|Unprocessed|APF-G1
1525513|IGL00663|11|77137036|S->A||0.84|Possibly damaging|0.9|tolerated|MGI:2442440|Efcab5|EF-hand calcium binding domain 5 [Source:MGI Symbol;Acc:MGI:2442440]|Heterozygous||A|C|119|38.0|Non-synonymous|Unprocessed|APF-G1
1525514|IGL00663|11|23757043|M->T||0.08|Benign|0.39|tolerated|MGI:97897|Rel|reticuloendotheliosis oncogene [Source:MGI Symbol;Acc:MGI:97897]|Heterozygous||A|G|91|41.0|Non-synonymous|Unprocessed|APF-G1
1525515|IGL00663|X|36889099|T->N||0.93|Possibly damaging|0.19|tolerated|MGI:1924536|Nkrf|NF-kappaB repressing factor [Source:MGI Symbol;Acc:MGI:1924536]|Heterozygous|Homozygous female and hemizygous male null mice are viable and fertile with normal inflammatory responses, response to infection, peripheral blood cell populations and skin morphology.|G|T|36|37.0|Non-synonymous|Unprocessed|APF-G1
1525516|IGL00663|1|193187138|K->N||1.0|Probably damaging||deleterious|MGI:2441706|Traf3ip3|TRAF3 interacting protein 3 [Source:MGI Symbol;Acc:MGI:2441706]|Heterozygous||T|A|35|40.0|Non-synonymous|Unprocessed|APF-G1
1525517|IGL00663|5|8927916|E->G||1.0|Probably damaging||deleterious|MGI:97569|Abcb4|ATP-binding cassette, sub-family B (MDR/TAP), member 4 [Source:MGI Symbol;Acc:MGI:97569]|Heterozygous|Mice homozygous for targeted mutations that inactivate the gene are unable to secrete phospholipids into bile, leading to progressive hepatic disease, with an end stage of 3 months.|A|G|32|38.5|Non-synonymous|Unprocessed|APF-G1
1525518|IGL00663|2|122167714|T->A|||Benign|0.5|tolerated|MGI:1918178|Trim69|tripartite motif-containing 69 [Source:MGI Symbol;Acc:MGI:1918178]|Heterozygous||A|G|29|36.0|Non-synonymous|Unprocessed|APF-G1
1525519|IGL00663|5|37421891|V->A||0.02|Benign|0.09|tolerated|MGI:1915775|Evc2|Ellis van Creveld syndrome 2 homolog (human) [Source:MGI Symbol;Acc:MGI:1915775]|Heterozygous||T|C|25|36.0|Non-synonymous|Unprocessed|APF-G1
1525520|IGL00663|13|64922788|Q->Stop|||N/A|||MGI:1925374|4930458l03rik|RIKEN cDNA 4930458L03 gene [Source:MGI Symbol;Acc:MGI:1925374]|Heterozygous||C|T|18|39.0|Non-synonymous|Unprocessed|APF-G1
1525521|IGL00663|15|55411585|I->T|||Unknown|||MGI:1341272|Col14a1|collagen, type XIV, alpha 1 [Source:MGI Symbol;Acc:MGI:1341272]|Heterozygous|Mice homozygous for a null mutation display abnormal tendon morphology and abnormal biomechanical properties of the skin and tendons.|T|C|18|38.0|Non-synonymous|Unprocessed|APF-G1
1525522|IGL00663|13|4248129|Disrupted splicing|||N/A|||MGI:2653678|Akr1c19|aldo-keto reductase family 1, member C19 [Source:MGI Symbol;Acc:MGI:2653678]|Heterozygous||C|T|20|39.0|Splice|Unprocessed|APF-G1
1526012|IGL00664|11|64980650|V->A||0.79|Possibly damaging|0.15|tolerated|MGI:1890496|Elac2|elaC homolog 2 (E. coli) [Source:MGI Symbol;Acc:MGI:1890496]|Heterozygous||T|C|70|39.0|Non-synonymous|Unprocessed|APF-G1
1526013|IGL00664|11|107077665|D->V||0.03|Benign|||MGI:2444008|Bptf|bromodomain PHD finger transcription factor [Source:MGI Symbol;Acc:MGI:2444008]|Heterozygous|Mice homozygous for a null mutation display embryonic lethality during organogenesis with embryonic growth arrest around early gastrulation and a greatly reduced ectoplacental cone.|T|A|62|39.0|Non-synonymous|Unprocessed|APF-G1
1526014|IGL00664|8|43625969|V->E|||Benign|1.0|tolerated|MGI:3647273|Gm5346|predicted gene 5346 [Source:MGI Symbol;Acc:MGI:3647273]|Heterozygous||A|T|45|37.0|Non-synonymous|Unprocessed|APF-G1
1526015|IGL00664|4|88842099|V->A||0.09|Benign|0.05|deleterious|MGI:107664|Ifna4|interferon alpha 4 [Source:MGI Symbol;Acc:MGI:107664]|Heterozygous||T|C|22|39.5|Non-synonymous|Unprocessed|APF-G1
1526016|IGL00664|3|145027899|T->M||0.01|Benign|0.11|tolerated|MGI:1346342|Clca3|chloride channel calcium activated 3 [Source:MGI Symbol;Acc:MGI:1346342]|Heterozygous|Mice homozygous for a null allele exhibit an exacerbated mucin response.|G|A|19|38.0|Non-synonymous|Unprocessed|APF-G1
1526017|IGL00664|4|105015716|I->T||1.0|Probably damaging||deleterious|MGI:2685466|1700024p16rik|RIKEN cDNA 1700024P16 gene [Source:MGI Symbol;Acc:MGI:2685466]|Heterozygous||T|C|19|40.0|Non-synonymous|Unprocessed|APF-G1
1527024|IGL00666|2|146485136|S->G||0.62|Possibly damaging|0.21|tolerated|MGI:3036245|Ralgapa2|Ral GTPase activating protein, alpha subunit 2 (catalytic) [Source:MGI Symbol;Acc:MGI:3036245]|Heterozygous||T|C|153|41.0|Non-synonymous|Unprocessed|APF-G1
1527025|IGL00666|16|73961700|T->S|||Benign|0.35|tolerated|MGI:1890110|Robo2|roundabout homolog 2 (Drosophila) [Source:MGI Symbol;Acc:MGI:1890110]|Heterozygous|Homozygous mutants display postnatal lethality, abnormal ureteric bud development, multiple fused kidneys, multiple ureters, and abnormal commissural axon growth.|T|A|106|39.0|Non-synonymous|Unprocessed|APF-G1
1527026|IGL00666|13|12410450|S->R||0.08|Benign|0.27|tolerated|MGI:2442524|Heatr1|HEAT repeat containing 1 [Source:MGI Symbol;Acc:MGI:2442524]|Heterozygous||T|A|70|39.0|Non-synonymous|Unprocessed|APF-G1
1527027|IGL00666|8|16189990|T->K||0.92|Possibly damaging|0.02|deleterious|MGI:2137383|Csmd1|CUB and Sushi multiple domains 1 [Source:MGI Symbol;Acc:MGI:2137383]|Heterozygous||G|T|54|39.0|Non-synonymous|Unprocessed|APF-G1
1527028|IGL00666|10|85629216|V->A||0.32|Benign|0.3|tolerated|MGI:1921257|Btbd11|BTB (POZ) domain containing 11 [Source:MGI Symbol;Acc:MGI:1921257]|Heterozygous||T|C|50|39.0|Non-synonymous|Unprocessed|APF-G1
1527029|IGL00666|2|119070464|I->K||0.66|Possibly damaging|0.03|deleterious|MGI:1923714|Casc5|cancer susceptibility candidate 5 [Source:MGI Symbol;Acc:MGI:1923714]|Heterozygous||T|A|45|39.0|Non-synonymous|Unprocessed|APF-G1
1527030|IGL00666|6|82956665|Y->D||1.0|Probably damaging||deleterious|MGI:1315200|D6mm5e|DNA segment, Chr 6, Miriam Meisler 5, expressed [Source:MGI Symbol;Acc:MGI:1315200]|Heterozygous||T|G|44|38.5|Non-synonymous|Unprocessed|APF-G1
1527031|IGL00666|16|15736835|R->H||1.0|Probably damaging|0.01|deleterious|MGI:104779|Prkdc|protein kinase, DNA activated, catalytic polypeptide [Source:MGI Symbol;Acc:MGI:104779]|Heterozygous|Mutations at this locus effect genome stability, radiation sensitivity and DNA repair. Nonsense (scid) and null homozygotes have severe combined immunodeficiency. A BALB/c variant allele reduces enzyme activity and predisposes to breast cancer.|G|A|34|39.0|Non-synonymous|Unprocessed|APF-G1
1527032|IGL00666|13|84294596|Disrupted splicing|||N/A|||MGI:1919995|Tmem161b|transmembrane protein 161B [Source:MGI Symbol;Acc:MGI:1919995]|Heterozygous||A|G|102|39.0|Splice|Unprocessed|APF-G1
1527555|IGL00667|19|16759676|D->G||1.0|Probably damaging|0.02|deleterious|MGI:2444304|Vps13a|vacuolar protein sorting 13A (yeast) [Source:MGI Symbol;Acc:MGI:2444304]|Heterozygous|Aging mice homozygous for a knock-out allele display motor dysfunction and abnormal social interaction, hematologic anomalies including acanthocytosis, selective atrophy of the striatum with significant apoptosis and gliosis, and reduced homovanillic acid levels in midbrain.|T|C|185|41.0|Non-synonymous|Unprocessed|APF-G1
1527556|IGL00667|14|68521938|V->I||1.0|Probably damaging|0.41|tolerated|MGI:107247|Adam7|a disintegrin and metallopeptidase domain 7 [Source:MGI Symbol;Acc:MGI:107247]|Heterozygous||C|T|87|40.0|Non-synonymous|Unprocessed|APF-G1
1527557|IGL00667|18|74300192|M->R||0.99|Probably damaging||deleterious|MGI:1921703|Ccdc11|coiled-coil domain containing 11 [Source:MGI Symbol;Acc:MGI:1921703]|Heterozygous||T|G|58|40.0|Non-synonymous|Unprocessed|APF-G1
1527558|IGL00667|9|78684877|Y->H||1.0|Probably damaging|0.4|tolerated|MGI:2445221|Cd109|CD109 antigen [Source:MGI Symbol;Acc:MGI:2445221]|Heterozygous||T|C|53|38.0|Non-synonymous|Unprocessed|APF-G1
1527559|IGL00667|6|136400998|D->V||0.19|Benign||deleterious|MGI:2141773|E330021d16rik|RIKEN cDNA E330021D16 gene [Source:MGI Symbol;Acc:MGI:2141773]|Heterozygous||T|A|52|39.0|Non-synonymous|Unprocessed|APF-G1
1527560|IGL00667|9|44824386|C->G|||Unknown|0.01|deleterious|MGI:96995|Mll1|myeloid/lymphoid or mixed-lineage leukemia 1 [Source:MGI Symbol;Acc:MGI:96995]|Heterozygous|Homozygotes for targeted null mutations die at embryonic day 11.5-14.5 with edematous bodies, petechiae, and hematopoietic insufficiency. Heterozygotes show reduced growth, hematopoietic abnormalities, and homeotic transformations of the axial skeleton.|A|C|37|39.0|Non-synonymous|Unprocessed|APF-G1
1527561|IGL00667|16|96161412|S->P||0.73|Possibly damaging|0.22|tolerated|MGI:3041157|Lca5l|Leber congenital amaurosis 5-like [Source:MGI Symbol;Acc:MGI:3041157]|Heterozygous||A|G|33|38.0|Non-synonymous|Unprocessed|APF-G1
1527562|IGL00667|2|181589733|S->N||0.99|Probably damaging|0.05|deleterious|MGI:2685478|Znf512b|zinc finger protein 512B [Source:MGI Symbol;Acc:MGI:2685478]|Heterozygous||C|T|25|38.0|Non-synonymous|Unprocessed|APF-G1
1527563|IGL00667|9|5303756|I->V||0.01|Benign|0.89|tolerated|MGI:96544|Casp1|caspase 1 [Source:MGI Symbol;Acc:MGI:96544]|Heterozygous|Homozygous targeted mutants fail to produce mature IL1A and IL1B and are resistant to LPS-induced endotoxin shock and to FAS antibody-induced apoptosis.|A|G|21|40.0|Non-synonymous|Unprocessed|APF-G1
1527564|IGL00667|16|88506157|Disrupted splicing|||N/A|||MGI:2652030|Cldn17|claudin 17 [Source:MGI Symbol;Acc:MGI:2652030]|Heterozygous||A|T|75|41.0|Splice|Unprocessed|APF-G1
1527565|IGL00667|9|5352665|Disrupted splicing|||N/A|||MGI:1312922|Casp12|caspase 12 [Source:MGI Symbol;Acc:MGI:1312922]|Heterozygous|Homozygous mice for some mutations of this gene display resistance to ER stress-induced apoptosis.|A|G|37|39.0|Splice|Unprocessed|APF-G1
1528077|IGL00668|2|65353782|D->V||0.99|Probably damaging||deleterious|MGI:2443383|Slc38a11|solute carrier family 38, member 11 [Source:MGI Symbol;Acc:MGI:2443383]|Heterozygous||T|A|134|40.0|Non-synonymous|Unprocessed|APF-G1
1528078|IGL00668|15|66632849|Y->N||0.99|Probably damaging|0.12|tolerated|MGI:2444412|Phf20l1|PHD finger protein 20-like 1 [Source:MGI Symbol;Acc:MGI:2444412]|Heterozygous||T|A|111|40.0|Non-synonymous|Unprocessed|APF-G1
1528079|IGL00668|3|152742536|T->A||0.05|Benign|0.11|tolerated|MGI:1913863|Pigk|phosphatidylinositol glycan anchor biosynthesis, class K [Source:MGI Symbol;Acc:MGI:1913863]|Heterozygous||A|G|66|38.0|Non-synonymous|Unprocessed|APF-G1
1528080|IGL00668|X|107947196|Y->F||0.4|Benign|||MGI:2685578|Gm732|predicted gene 732 [Source:MGI Symbol;Acc:MGI:2685578]|Heterozygous||T|A|57|40.0|Non-synonymous|Unprocessed|APF-G1
1528081|IGL00668|X|101281186|S->P|||Benign|0.34|tolerated|MGI:1926212|Med12|mediator of RNA polymerase II transcription, subunit 12 homolog (yeast) [Source:MGI Symbol;Acc:MGI:1926212]|Heterozygous||T|C|46|39.0|Non-synonymous|Unprocessed|APF-G1
1528082|IGL00668|15|99802157|V->E||0.99|Probably damaging||deleterious|MGI:1920992|Lima1|LIM domain and actin binding 1 [Source:MGI Symbol;Acc:MGI:1920992]|Heterozygous||A|T|36|39.0|Non-synonymous|Unprocessed|APF-G1
1528083|IGL00668|11|87797334|N->S|||Benign|0.2|tolerated|MGI:97137|Mpo|myeloperoxidase [Source:MGI Symbol;Acc:MGI:97137]|Heterozygous||A|G|28|38.5|Non-synonymous|Unprocessed|APF-G1
1528084|IGL00668|18|49939553|L->P||0.35|Benign||deleterious|MGI:2443926|Dmxl1|Dmx-like 1 [Source:MGI Symbol;Acc:MGI:2443926]|Heterozygous||T|C|28|40.0|Non-synonymous|Unprocessed|APF-G1
1528085|IGL00668|6|67423628|T->A||0.96|Probably damaging|0.36|tolerated|MGI:2181693|Il23r|interleukin 23 receptor [Source:MGI Symbol;Acc:MGI:2181693]|Heterozygous|Th17 T cells from homozygous null mice have less secretion of IL-9 upon secondary stimulation.|T|C|27|38.0|Non-synonymous|Unprocessed|APF-G1
1528086|IGL00668|12|116257428|H->R||0.1|Benign|0.01|deleterious|MGI:2445085|Wdr60|WD repeat domain 60 [Source:MGI Symbol;Acc:MGI:2445085]|Heterozygous||T|C|26|38.5|Non-synonymous|Unprocessed|APF-G1
1528087|IGL00668|15|47913945|D->E||1.0|Probably damaging||deleterious|MGI:2386403|Csmd3|CUB and Sushi multiple domains 3 [Source:MGI Symbol;Acc:MGI:2386403]|Heterozygous||A|T|25|39.0|Non-synonymous|Unprocessed|APF-G1
1528088|IGL00668|18|78857770|E->G||1.0|Probably damaging||deleterious|MGI:1933199|Setbp1|SET binding protein 1 [Source:MGI Symbol;Acc:MGI:1933199]|Heterozygous||T|C|17|35.0|Non-synonymous|Unprocessed|APF-G1
1528089|IGL00668|2|144559218|Disrupted splicing|||N/A|||MGI:1350925|Sec23b|SEC23B (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1350925]|Heterozygous||A|G|96|39.0|Splice|Unprocessed|APF-G1
1528090|IGL00668|17|34420420|Disrupted splicing|||N/A|||MGI:3039565|Bc051142|cDNA sequence BC051142 [Source:MGI Symbol;Acc:MGI:3039565]|Heterozygous||A|G|34|40.0|Splice|Unprocessed|APF-G1
1528091|IGL00668|2|29993956|Disrupted splicing|||N/A|||MGI:98386|Spna2|spectrin alpha 2 [Source:MGI Symbol;Acc:MGI:98386]|Heterozygous|Homozygous deletion of the exons encoding the CCC (calpain, caspase, calmodulin ) region are healthy, fertile and behaviorally normal with no detectable histological abnormalities at the cellular or organ level.|G|A|24|40.0|Splice|Unprocessed|APF-G1
1528575|IGL00669|1|52904670|I->K|||Benign|0.11|tolerated|MGI:1923792|Hibch|3-hydroxyisobutyryl-Coenzyme A hydrolase [Source:MGI Symbol;Acc:MGI:1923792]|Heterozygous||T|A|126|41.0|Non-synonymous|Unprocessed|APF-G1
1528576|IGL00669|9|67858844|A->D||1.0|Probably damaging||deleterious|MGI:2444207|Vps13c|vacuolar protein sorting 13C (yeast) [Source:MGI Symbol;Acc:MGI:2444207]|Heterozygous||C|A|119|39.0|Non-synonymous|Unprocessed|APF-G1
1528577|IGL00669|17|28991337|F->L||0.17|Benign||deleterious|MGI:2442572|Stk38|serine/threonine kinase 38 [Source:MGI Symbol;Acc:MGI:2442572]|Heterozygous||A|T|111|36.0|Non-synonymous|Unprocessed|APF-G1
1528578|IGL00669|X|66654165|N->K||1.0|Probably damaging|0.1|tolerated|MGI:2679449|Slitrk2|SLIT and NTRK-like family, member 2 [Source:MGI Symbol;Acc:MGI:2679449]|Heterozygous||T|A|50|39.5|Non-synonymous|Unprocessed|APF-G1
1528579|IGL00669|10|76000442|E->G||0.55|Possibly damaging||deleterious|MGI:3646667|Gm5134|predicted gene 5134 [Source:MGI Symbol;Acc:MGI:3646667]|Heterozygous||A|G|46|37.5|Non-synonymous|Unprocessed|APF-G1
1528580|IGL00669|13|67619264|H->Y||0.87|Possibly damaging||deleterious|MGI:3036250|A530054k11rik|RIKEN cDNA A530054K11 gene [Source:MGI Symbol;Acc:MGI:3036250]|Heterozygous||G|A|46|37.5|Non-synonymous|Unprocessed|APF-G1
1528581|IGL00669|X|50902077|R->G||0.83|Possibly damaging|0.24|tolerated|MGI:2686379|Frmd7|FERM domain containing 7 [Source:MGI Symbol;Acc:MGI:2686379]|Heterozygous||T|C|34|39.0|Non-synonymous|Unprocessed|APF-G1
1528582|IGL00669|17|87411270|R->C||1.0|Probably damaging||deleterious|MGI:1922717|1700011e24rik|RIKEN cDNA 1700011E24 gene [Source:MGI Symbol;Acc:MGI:1922717]|Heterozygous||G|A|33|39.0|Non-synonymous|Unprocessed|APF-G1
1528583|IGL00669|6|83802439|Y->C||1.0|Probably damaging|0.01|deleterious|MGI:1860418|Nagk|N-acetylglucosamine kinase [Source:MGI Symbol;Acc:MGI:1860418]|Heterozygous|A gene trap insertion into an intron of this gene results in no obvious phenotype.|A|G|31|39.0|Non-synonymous|Unprocessed|APF-G1
1528584|IGL00669|17|14685882|T->K||0.68|Possibly damaging||deleterious|MGI:98738|Thbs2|thrombospondin 2 [Source:MGI Symbol;Acc:MGI:98738]|Heterozygous|Mice homozygous for a knock-out allele display premature death, abnormal tails, marked structural and functional abnormalities in a variety of connective tissues including skin, tendon, bone, and blood vessels, accelerated wound healing, and enhanced susceptibility to experimental skin tumors.|G|T|26|39.0|Non-synonymous|Unprocessed|APF-G1
1528585|IGL00669|4|68826878|D->V||1.0|Probably damaging||deleterious|MGI:1928478|Dbc1|deleted in bladder cancer 1 (human) [Source:MGI Symbol;Acc:MGI:1928478]|Heterozygous||T|A|24|39.0|Non-synonymous|Unprocessed|APF-G1
1528586|IGL00669|19|11101831|H->N||0.01|Benign|||MGI:1916619|1700017d01rik|RIKEN cDNA 1700017D01 gene [Source:MGI Symbol;Acc:MGI:1916619]|Heterozygous||G|T|23|41.0|Non-synonymous|Unprocessed|APF-G1
1528587|IGL00669|18|61127949|K->N||0.27|Benign|0.02|deleterious|MGI:1339758|Csf1r|colony stimulating factor 1 receptor [Source:MGI Symbol;Acc:MGI:1339758]|Heterozygous|Homozygotes for a targeted null mutation exhibit skeletal, sensory, and reproductive abnormalities associated with severe deficiencies in osteoclasts, macrophages, and brain microglia.|G|T|21|38.0|Non-synonymous|Unprocessed|APF-G1
1528588|IGL00669|3|138424186|V->F||1.0|Probably damaging|0.02|deleterious|MGI:1349472|Adh4|alcohol dehydrogenase 4 (class II), pi polypeptide [Source:MGI Symbol;Acc:MGI:1349472]|Heterozygous||G|T|20|41.0|Non-synonymous|Unprocessed|APF-G1
1528589|IGL00669|17|27705748|K->Stop|||N/A|||MGI:1345181|Pacsin1|protein kinase C and casein kinase substrate in neurons 1 [Source:MGI Symbol;Acc:MGI:1345181]|Heterozygous||A|T|19|39.0|Non-synonymous|Unprocessed|APF-G1
1528590|IGL00669|5|122116925|N->S||0.92|Possibly damaging|0.2|tolerated|MGI:3607777|Ccdc63|coiled-coil domain containing 63 [Source:MGI Symbol;Acc:MGI:3607777]|Heterozygous||T|C|19|34.0|Non-synonymous|Unprocessed|APF-G1
1528591|IGL00669|10|5801897|T->A||0.01|Benign|0.29|tolerated|MGI:1914391|Fbxo5|F-box protein 5 [Source:MGI Symbol;Acc:MGI:1914391]|Heterozygous|Mice homozygous for a null mutation display embryonic lethality before implantation, impaired embryogenesis, and mitotic abnormalities.|A|G|18|39.0|Non-synonymous|Unprocessed|APF-G1
1528592|IGL00669|10|77041936|V->M||0.05|Benign|0.05|tolerated|MGI:103182|Slc19a1|solute carrier family 19 (sodium/hydrogen exchanger), member 1 [Source:MGI Symbol;Acc:MGI:103182]|Heterozygous|Homozygous null embryos die due to abnormalities of hematopoietic organs. Mutant mice may be partially rescued with maternal folic acid supplementation, but these mice still present with hematopoietic organ defects and show impaired development of urogenital structures.|G|A|16|36.0|Non-synonymous|Unprocessed|APF-G1
1528593|IGL00669|11|120787781|I->F||0.41|Benign||deleterious|MGI:2384801|Gps1|G protein pathway suppressor 1 [Source:MGI Symbol;Acc:MGI:2384801]|Heterozygous||A|T|16|34.5|Non-synonymous|Unprocessed|APF-G1
1528594|IGL00669|4|43930993|Q->Stop|||N/A|||MGI:1855698|Reck|reversion-inducing-cysteine-rich protein with kazal motifs [Source:MGI Symbol;Acc:MGI:1855698]|Heterozygous|Homozygous mutation of this gene results in lethality around E10.5-E11.5, defects in collagen fibrils, basal lamina and vascular development.|C|T|16|40.0|Non-synonymous|Unprocessed|APF-G1
1529115|IGL00670|12|4764081|K->E||0.88|Possibly damaging|0.01|deleterious|MGI:2442121|A830093i24rik|RIKEN cDNA A830093I24 gene [Source:MGI Symbol;Acc:MGI:2442121]|Heterozygous||T|C|88|41.0|Non-synonymous|Unprocessed|APF-G1
1529116|IGL00670|8|22429190|D->G||0.97|Probably damaging||deleterious|MGI:1913153|Mrps31|mitochondrial ribosomal protein S31 [Source:MGI Symbol;Acc:MGI:1913153]|Heterozygous||A|G|63|40.0|Non-synonymous|Unprocessed|APF-G1
1529117|IGL00670|6|14719060|N->K||0.01|Benign|0.81|tolerated|MGI:2153588|Ppp1r3a|protein phosphatase 1, regulatory (inhibitor) subunit 3A [Source:MGI Symbol;Acc:MGI:2153588]|Heterozygous|Homozygous mutant mice have reduced levels of skeletal muscle glycogen. Whereas one model was normoglycemic and grossly normal, another on a similar genetic background was glucose intolerant, insulin resistant, and gained weight to the point of obesity.|A|T|53|39.0|Non-synonymous|Unprocessed|APF-G1
1529118|IGL00670|X|106445777|D->G|||Benign|0.81|tolerated|MGI:2685630|Fndc3c1|fibronectin type III domain containing 3C1 [Source:MGI Symbol;Acc:MGI:2685630]|Heterozygous||T|C|35|38.0|Non-synonymous|Unprocessed|APF-G1
1529119|IGL00670|13|3585241|I->N||0.14|Benign|0.3|tolerated|MGI:2145274|Bc016423|cDNA sequence BC016423 [Source:MGI Symbol;Acc:MGI:2145274]|Heterozygous||A|T|34|40.0|Non-synonymous|Unprocessed|APF-G1
1529120|IGL00670|4|96634275|D->A||0.87|Possibly damaging|0.15|tolerated|MGI:1270149|Cyp2j5|cytochrome P450, family 2, subfamily j, polypeptide 5 [Source:MGI Symbol;Acc:MGI:1270149]|Heterozygous|Female mice homozygous for a null mutation display increased systolic blood pressure, increased left ventricular weight, decreased litter sizes, decreased serum estrogen levels, and increased induced vasoconstriction responses.|T|G|34|35.5|Non-synonymous|Unprocessed|APF-G1
1529121|IGL00670|X|12754189|A->V||0.33|Benign|0.01|deleterious|MGI:1349442|Med14|mediator complex subunit 14 [Source:MGI Symbol;Acc:MGI:1349442]|Heterozygous||G|A|34|40.0|Non-synonymous|Unprocessed|APF-G1
1529122|IGL00670|15|82791741|M->L|||Benign|1.0|tolerated|MGI:1923529|Cyp2d26|cytochrome P450, family 2, subfamily d, polypeptide 26 [Source:MGI Symbol;Acc:MGI:1923529]|Heterozygous||T|A|25|35.0|Non-synonymous|Unprocessed|APF-G1
1529123|IGL00670|X|69544593|M->K||0.76|Possibly damaging|0.69|tolerated|MGI:1202294|Aff2|AF4/FMR2 family, member 2 [Source:MGI Symbol;Acc:MGI:1202294]|Heterozygous|Homozygotes for a targeted null mutation exhibit impaired conditioned fear responses and enhanced long-term potentiation in hippocampal slices.|T|A|25|40.0|Non-synonymous|Unprocessed|APF-G1
1529124|IGL00670|6|142687281|L->Q||1.0|Probably damaging|0.3|tolerated|MGI:1352630|Abcc9|ATP-binding cassette, sub-family C (CFTR/MRP), member 9 [Source:MGI Symbol;Acc:MGI:1352630]|Heterozygous|Mice homozygous for disruptions in this gene display lower serum glucose, enhanced insulin action, growth retardation, hypertension and spontaneous death starting at 6 weeks of age due to episodic coronary artery vasospasm.|A|T|23|39.0|Non-synonymous|Unprocessed|APF-G1
1529125|IGL00670|10|76163733|I->F||1.0|Probably damaging||deleterious|MGI:1927848|Slc5a4a|solute carrier family 5, member 4a [Source:MGI Symbol;Acc:MGI:1927848]|Heterozygous||A|T|22|38.0|Non-synonymous|Unprocessed|APF-G1
1529126|IGL00670|3|121775684|V->D||0.99|Probably damaging||deleterious|MGI:1349216|Abcd3|ATP-binding cassette, sub-family D (ALD), member 3 [Source:MGI Symbol;Acc:MGI:1349216]|Heterozygous||A|T|20|36.0|Non-synonymous|Unprocessed|APF-G1
1529127|IGL00670|10|24888584|L->P||0.98|Probably damaging|0.29|tolerated|MGI:1917458|Med23|mediator complex subunit 23 [Source:MGI Symbol;Acc:MGI:1917458]|Heterozygous||T|C|17|38.0|Non-synonymous|Unprocessed|APF-G1
1529128|IGL00670|6|132207146|Disrupted splicing|||N/A|||MGI:2681872|Prb1|proline-rich protein BstNI subfamily 1 [Source:MGI Symbol;Acc:MGI:2681872]|Heterozygous||A|T|35|37.0|Splice|Unprocessed|APF-G1
1529129|IGL00670|11|93304657|Disrupted splicing|||N/A|||MGI:1919855|Car10|carbonic anhydrase 10 [Source:MGI Symbol;Acc:MGI:1919855]|Heterozygous||C|T|19|40.0|Splice|Unprocessed|APF-G1
1529130|IGL00670|2|76826991|Disrupted splicing|||N/A|||MGI:98864|Ttn|titin [Source:MGI Symbol;Acc:MGI:98864]|Heterozygous|Homozygous mutant mice show embryogenesis defects in frontonasal mass, first branchial arch and somites, and vascular, cardiac and skeletal muscle defects causing growth retardation, muscle weakness, abnormal posture, and premature death ranging from embryonic day 11.5 to 8 weeks of age.|A|T|16|34.5|Splice|Unprocessed|APF-G1
1529578|IGL00671|17|65864612|E->V||1.0|Probably damaging|0.01|deleterious|MGI:108466|Ralbp1|ralA binding protein 1 [Source:MGI Symbol;Acc:MGI:108466]|Heterozygous|Homozygous and heterozygous null mice display increased sensitivity to X-ray irradiation, increased oxidative stress, and impaired glutathione homeostasis.|T|A|313|39.0|Non-synonymous|Unprocessed|APF-G1
1529579|IGL00671|1|139133737|I->F||0.97|Probably damaging||deleterious|MGI:2447812|Dennd1b|DENN/MADD domain containing 1B [Source:MGI Symbol;Acc:MGI:2447812]|Heterozygous||A|T|123|39.0|Non-synonymous|Unprocessed|APF-G1
1529580|IGL00671|8|71932542|R->Stop|||N/A|||MGI:2684459|Zfp617|zinc finger protein 617 [Source:MGI Symbol;Acc:MGI:2684459]|Heterozygous||C|T|52|37.0|Non-synonymous|Unprocessed|APF-G1
1529581|IGL00671|10|94789764|T->A||0.28|Benign|0.32|tolerated|MGI:1924298|Ccdc41|coiled-coil domain containing 41 [Source:MGI Symbol;Acc:MGI:1924298]|Heterozygous||A|G|50|39.0|Non-synonymous|Unprocessed|APF-G1
1529582|IGL00671|14|119042799|T->A|||Benign|0.11|tolerated|MGI:1913685|Uggt2|UDP-glucose glycoprotein glucosyltransferase 2 [Source:MGI Symbol;Acc:MGI:1913685]|Heterozygous||T|C|50|40.0|Non-synonymous|Unprocessed|APF-G1
1529583|IGL00671|1|31222972|V->I|||Benign|0.04|deleterious|MGI:1921958|4930521a18rik|RIKEN cDNA 4930521A18 gene [Source:MGI Symbol;Acc:MGI:1921958]|Heterozygous||G|A|48|39.0|Non-synonymous|Unprocessed|APF-G1
1529584|IGL00671|11|115331909|N->S||1.0|Probably damaging|0.01|deleterious|MGI:2388365|Otop2|otopetrin 2 [Source:MGI Symbol;Acc:MGI:2388365]|Heterozygous||A|G|45|36.0|Non-synonymous|Unprocessed|APF-G1
1529585|IGL00671|8|85093938|D->A||0.93|Possibly damaging|0.01|deleterious|MGI:107286|Man2b1|mannosidase 2, alpha B1 [Source:MGI Symbol;Acc:MGI:107286]|Heterozygous|Mice homozygous for a knock-out allele show urinary oligosaccharide excretion, storage of neutral sugars, oligosaccharide buildup in spleen, kidney, liver, testis and brain, clear vacuoles and axonal spheroids in CNS, PNS and other cell types, behavioral changes, and enhanced long-term potentiation.|A|C|44|38.5|Non-synonymous|Unprocessed|APF-G1
1529586|IGL00671|1|26684859|S->R||0.92|Possibly damaging|0.4|tolerated|MGI:3588222|4931408c20rik|RIKEN cDNA 4931408C20 gene [Source:MGI Symbol;Acc:MGI:3588222]|Heterozygous||A|T|40|38.0|Non-synonymous|Unprocessed|APF-G1
1529587|IGL00671|9|71868118|N->I||0.98|Probably damaging|0.01|deleterious|MGI:101877|Tcf12|transcription factor 12 [Source:MGI Symbol;Acc:MGI:101877]|Heterozygous|Mice homozygous for a targeted null mutation exhibit postnatal lethality within two weeks of birth and a 50% reduction in the number of pro-B cells.|T|A|39|39.0|Non-synonymous|Unprocessed|APF-G1
1529588|IGL00671|8|10361067|I->N||1.0|Probably damaging||deleterious|MGI:2685951|Myo16|myosin XVI [Source:MGI Symbol;Acc:MGI:2685951]|Heterozygous||T|A|38|38.0|Non-synonymous|Unprocessed|APF-G1
1529589|IGL00671|5|8930745|R->Stop|||N/A|||MGI:97569|Abcb4|ATP-binding cassette, sub-family B (MDR/TAP), member 4 [Source:MGI Symbol;Acc:MGI:97569]|Heterozygous|Mice homozygous for targeted mutations that inactivate the gene are unable to secrete phospholipids into bile, leading to progressive hepatic disease, with an end stage of 3 months.|A|T|35|39.0|Non-synonymous|Unprocessed|APF-G1
1529590|IGL00671|15|88914153|D->G||0.95|Possibly damaging|0.39|tolerated|MGI:1922902|Ttll8|tubulin tyrosine ligase-like family, member 8 [Source:MGI Symbol;Acc:MGI:1922902]|Heterozygous||T|C|34|35.0|Non-synonymous|Unprocessed|APF-G1
1529591|IGL00671|3|27138669|N->S|||Benign|0.67|tolerated|MGI:95281|Ect2|ect2 oncogene [Source:MGI Symbol;Acc:MGI:95281]|Heterozygous|Homozygous disruption of this locus is embryonic lethal.|T|C|31|38.0|Non-synonymous|Unprocessed|APF-G1
1529592|IGL00671|10|122449351|I->L|||Benign|0.4|tolerated|MGI:1859216|Avpr1a|arginine vasopressin receptor 1A [Source:MGI Symbol;Acc:MGI:1859216]|Heterozygous|Mice homozygous for disruptions in this gene display a stimulus processing deficit similar to that seen in schizophrenia. Anxiety-like behaviors are reduced in males but not females.  B cell development is also affected.|A|T|30|37.0|Non-synonymous|Unprocessed|APF-G1
1529593|IGL00671|19|45765540|A->S||0.21|Benign|0.4|tolerated|MGI:1932139|Mgea5|meningioma expressed antigen 5 (hyaluronidase) [Source:MGI Symbol;Acc:MGI:1932139]|Heterozygous||C|A|27|38.0|Non-synonymous|Unprocessed|APF-G1
1529594|IGL00671|3|10346024|H->R||1.0|Probably damaging||deleterious|MGI:1913611|Zfand1|zinc finger, AN1-type domain 1 [Source:MGI Symbol;Acc:MGI:1913611]|Heterozygous||T|C|24|38.5|Non-synonymous|Unprocessed|APF-G1
1529595|IGL00671|9|61412370|N->K||0.97|Probably damaging|0.18|tolerated|MGI:104634|Tle3|transducin-like enhancer of split 3, homolog of Drosophila E(spl) [Source:MGI Symbol;Acc:MGI:104634]|Heterozygous|Mice homzoygous for a gene trap allele exhibit embryonic lethality.|T|A|18|37.5|Non-synonymous|Unprocessed|APF-G1
1529596|IGL00671|11|67193357|E->G|||N/A|0.05|deleterious|MGI:1339710|Myh2|myosin, heavy polypeptide 2, skeletal muscle, adult [Source:MGI Symbol;Acc:MGI:1339710]|Heterozygous||A|G|17|38.0|Non-synonymous|Unprocessed|APF-G1
1529597|IGL00671|14|117186787|T->S|||Benign|0.68|tolerated|MGI:1346322|Gpc6|glypican 6 [Source:MGI Symbol;Acc:MGI:1346322]|Heterozygous||A|T|17|39.0|Non-synonymous|Unprocessed|APF-G1
1529598|IGL00671|2|157333469|H->Y|||Benign|1.0|tolerated|MGI:95709|Ghrh|growth hormone releasing hormone [Source:MGI Symbol;Acc:MGI:95709]|Heterozygous||G|A|17|38.0|Non-synonymous|Unprocessed|APF-G1
1529599|IGL00671|4|121082815|Disrupted splicing|||N/A|||MGI:1890508|Zmpste24|zinc metallopeptidase, STE24 homolog (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1890508]|Heterozygous|Mutants are deficient in proteolytic processing of prelamin A and display many abnormalities including retarded growth, bone fragility, hair loss, cardiomyopathy, muscular dystrophy and lipodystrophy. Most die prematurely, but some survive and reproduce.|A|G|83|40.0|Splice|Unprocessed|APF-G1
1529600|IGL00671|1|5124471|Disrupted splicing|||N/A|||MGI:1914864|Atp6v1h|ATPase, H+ transporting, lysosomal V1 subunit H [Source:MGI Symbol;Acc:MGI:1914864]|Heterozygous||T|C|30|34.5|Splice|Unprocessed|APF-G1
1529601|IGL00671|5|30385753|Disrupted splicing|||N/A|||MGI:1891247|Otof|otoferlin [Source:MGI Symbol;Acc:MGI:1891247]|Heterozygous|Homozygous mutants have no detectable auditory brainstem response at any frequency tested. Otoacoustic transmission distortion products are detected. Direct electrical stimulation of cochlear ganglia elicits brainstem responses. On depolarization, inner hair cells release almost no neurotransmitter.|C|T|22|37.5|Splice|Unprocessed|APF-G1
1529602|IGL00671|2|127344021|Disrupted splicing|||N/A|||MGI:3046414|Astl|astacin-like metalloendopeptidase (M12 family) [Source:MGI Symbol;Acc:MGI:3046414]|Heterozygous||T|C|18|33.0|Splice|Unprocessed|APF-G1
1530119|IGL00672|14|79213398|D->E|||Unknown|||MGI:2145729|Zfp957|zinc finger protein 957 [Source:MGI Symbol;Acc:MGI:2145729]|Heterozygous||G|T|153|38.0|Non-synonymous|Unprocessed|APF-G1
1530120|IGL00672|3|65391410|A->S||0.03|Benign|0.46|tolerated|MGI:1914687|Ssr3|signal sequence receptor, gamma [Source:MGI Symbol;Acc:MGI:1914687]|Heterozygous|Mice homozygous for a null mutation display neonatal lethality with growth retardation, reduced placental size and impaired placental vascular development.|C|A|135|40.0|Non-synonymous|Unprocessed|APF-G1
1530121|IGL00672|4|121065860|I->T||1.0|Probably damaging||deleterious|MGI:1890508|Zmpste24|zinc metallopeptidase, STE24 homolog (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1890508]|Heterozygous|Mutants are deficient in proteolytic processing of prelamin A and display many abnormalities including retarded growth, bone fragility, hair loss, cardiomyopathy, muscular dystrophy and lipodystrophy. Most die prematurely, but some survive and reproduce.|A|G|128|38.0|Non-synonymous|Unprocessed|APF-G1
1530122|IGL00672|12|109593000|S->G|||Unknown|||MGI:2656842|Rtl1|retrotransposon-like 1 [Source:MGI Symbol;Acc:MGI:2656842]|Heterozygous|Mice heterozygous for a paternally inherited knock-out allele exhibit fetal/neonatal lethality associated with underdevelopment of the placenta.  Mice heteroygous for a maternally inherited knock-out allele exhibit neonatal lethality and decreased survival associated with placental overdevelopment.|T|C|116|39.0|Non-synonymous|Unprocessed|APF-G1
1530123|IGL00672|14|78511341|A->V||1.0|Probably damaging||deleterious|MGI:2684060|Akap11|A kinase (PRKA) anchor protein 11 [Source:MGI Symbol;Acc:MGI:2684060]|Heterozygous||G|A|113|37.0|Non-synonymous|Unprocessed|APF-G1
1530124|IGL00672|2|154887709|I->L|||Benign|1.0|tolerated|MGI:1914454|Eif2s2|eukaryotic translation initiation factor 2, subunit 2 (beta) [Source:MGI Symbol;Acc:MGI:1914454]|Heterozygous|Mice homozygous for a gene trap allele exhibit embryonic lethallity prior to E8.5.  Mice heterozygous for a gene trap allele exhibit reduced incidence of testicular germ cell tumors.|T|A|107|40.0|Non-synonymous|Unprocessed|APF-G1
1530125|IGL00672|7|66714531|K->Stop|||N/A|||MGI:1919885|Lins|lines homolog (Drosophila) [Source:MGI Symbol;Acc:MGI:1919885]|Heterozygous||A|T|92|37.0|Non-synonymous|Unprocessed|APF-G1
1530126|IGL00672|4|149381366|V->A||0.01|Benign|0.1|tolerated|MGI:1927086|Ube4b|ubiquitination factor E4B, UFD2 homolog (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1927086]|Heterozygous|Mice homozygous for a disruption in this gene die by midgestation and exhibit cardiac development defects such as hemorrhage and cardiomyocyte apoptosis. Heterozygous mice exhibit axonal dystrophy in the nucleus gracilis, degeneration of Purkinje cells and gait abnormalities.|A|G|80|38.0|Non-synonymous|Unprocessed|APF-G1
1530127|IGL00672|7|4028731|T->S||0.18|Benign|0.82|tolerated|MGI:105492|Lair1|leukocyte-associated Ig-like receptor 1 [Source:MGI Symbol;Acc:MGI:105492]|Heterozygous||T|A|73|37.0|Non-synonymous|Unprocessed|APF-G1
1530128|IGL00672|17|84444218|S->R||0.02|Benign|0.2|tolerated|MGI:3039623|Thada|thyroid adenoma associated [Source:MGI Symbol;Acc:MGI:3039623]|Heterozygous||A|T|70|37.0|Non-synonymous|Unprocessed|APF-G1
1530129|IGL00672|6|129733071|I->F||1.0|Probably damaging||deleterious|MGI:2443965|Klri2|killer cell lectin-like receptor family I member 2 [Source:MGI Symbol;Acc:MGI:2443965]|Heterozygous||T|A|70|37.0|Non-synonymous|Unprocessed|APF-G1
1530130|IGL00672|19|47082301|D->V||1.0|Probably damaging||deleterious|MGI:2442144|Taf5|TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor [Source:MGI Symbol;Acc:MGI:2442144]|Heterozygous||A|T|68|38.0|Non-synonymous|Unprocessed|APF-G1
1530131|IGL00672|4|96749182|L->P||1.0|Probably damaging|0.02|deleterious|MGI:3650206|Gm12695|predicted gene 12695 [Source:MGI Symbol;Acc:MGI:3650206]|Heterozygous||A|G|66|38.0|Non-synonymous|Unprocessed|APF-G1
1530132|IGL00672|4|74343514|N->S||0.02|Benign|0.02|deleterious|MGI:1924054|Kdm4c|lysine (K)-specific demethylase 4C [Source:MGI Symbol;Acc:MGI:1924054]|Heterozygous||A|G|63|39.0|Non-synonymous|Unprocessed|APF-G1
1530133|IGL00672|2|164118079|K->E||0.02|Benign|0.93|tolerated|MGI:1929004|Stk4|serine/threonine kinase 4 [Source:MGI Symbol;Acc:MGI:1929004]|Heterozygous|Mice homozygous for a gene trap allele have low numbers of na�ve T cells that are hyper-responsive to stimulation. Mice homozygous for knock-out alleles exhibit decreased peripheral T cell numbers due to impaired emigration and homing.|A|G|56|39.5|Non-synonymous|Unprocessed|APF-G1
1530134|IGL00672|12|76064184|T->M||0.84|Possibly damaging||deleterious|MGI:2449316|Syne2|synaptic nuclear envelope 2 [Source:MGI Symbol;Acc:MGI:2449316]|Heterozygous|Homozygotes for one knock-out allele show normal myonuclear positioning of both synaptic and non-synaptic nuclei in skeletal muscle cells. Homozygotes for another knock-out allele exhibit a thickened epidermis and altered nuclear envelope architecture in primary dermal fibroblasts and keratinocytes.|C|T|48|39.0|Non-synonymous|Unprocessed|APF-G1
1530135|IGL00672|5|122238471|F->L||0.33|Benign|0.14|tolerated|MGI:1921346|Hvcn1|hydrogen voltage-gated channel 1 [Source:MGI Symbol;Acc:MGI:1921346]|Heterozygous|Mice homozygous for a gene trap allele lack neutrophil and macrophage voltage-gated proton pumps.|C|A|48|37.0|Non-synonymous|Unprocessed|APF-G1
1530136|IGL00672|7|70357766|S->P|||Benign|0.96|tolerated|MGI:1352452|Nr2f2|nuclear receptor subfamily 2, group F, member 2 [Source:MGI Symbol;Acc:MGI:1352452]|Heterozygous|Homozygotes for a targeted null mutation exhibit impaired angiogenesis and heart development with hemorrhagic brains and hearts, and die around embryonic day 10. About 5% of heterozygotes share the hemorrhagic phenotype at embryonic day 9.5.|A|G|47|39.0|Non-synonymous|Unprocessed|APF-G1
1530137|IGL00672|2|129125472|M->I||1.0|Probably damaging||deleterious|MGI:108014|Polr1b|polymerase (RNA) I polypeptide B [Source:MGI Symbol;Acc:MGI:108014]|Heterozygous|Mice homozygous for a gene trapped allele exhibit embryonic lethality prior to implantation.|G|A|43|38.0|Non-synonymous|Unprocessed|APF-G1
1530138|IGL00672|11|82818484|P->S||1.0|Probably damaging|0.07|tolerated|MGI:1914588|Rffl|ring finger and FYVE like domain containing protein [Source:MGI Symbol;Acc:MGI:1914588]|Heterozygous|Mice homozygous for an inactivating targeted mutation of this gene are born at the expected Mendelian frequency; they are viable and fertile and exhibit no apparent abnormal phenotype.|G|A|40|38.0|Non-synonymous|Unprocessed|APF-G1
1530139|IGL00672|9|66007746|S->I||1.0|Probably damaging||deleterious|MGI:2660884|Csnk1g1|casein kinase 1, gamma 1 [Source:MGI Symbol;Acc:MGI:2660884]|Heterozygous||G|T|40|39.0|Non-synonymous|Unprocessed|APF-G1
1530140|IGL00672|15|32618880|E->G||0.35|Benign|0.04|deleterious|MGI:107556|Sema5a|sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A [Source:MGI Symbol;Acc:MGI:107556]|Heterozygous|Homozygous null mice die between E11.5 and E12.5 and exhibit decreased complexity of the hierarchically organized branches of the cranial cardinal veins. Mice homozygous for a second targeted mutation appear normal.|A|G|31|36.0|Non-synonymous|Unprocessed|APF-G1
1530141|IGL00672|4|117178246|I->V|||Benign|0.43|tolerated|MGI:1921054|Kif2c|kinesin family member 2C [Source:MGI Symbol;Acc:MGI:1921054]|Heterozygous||T|C|31|40.0|Non-synonymous|Unprocessed|APF-G1
1530142|IGL00672|15|99325681|Y->N||0.61|Possibly damaging||deleterious|MGI:109569|Fmnl3|formin-like 3 [Source:MGI Symbol;Acc:MGI:109569]|Heterozygous||A|T|30|39.0|Non-synonymous|Unprocessed|APF-G1
1530143|IGL00672|15|94341105|I->T||0.98|Probably damaging|0.02|deleterious|MGI:2660628|Adamts20|a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 20 [Source:MGI Symbol;Acc:MGI:2660628]|Heterozygous|Homozygous mutants have a white belt across the back in the midtrunk region and a white belly patch that coalesces to form a white belt.|A|G|28|37.0|Non-synonymous|Unprocessed|APF-G1
1530144|IGL00672|1|182440976|H->L||0.99|Probably damaging||deleterious|MGI:2138319|Trp53bp2|transformation related protein 53 binding protein 2 [Source:MGI Symbol;Acc:MGI:2138319]|Heterozygous|Homozygous mutation is lethal by 30 days of age, although majority die embryonically. Heterozygotes show increased susceptibility to spontaneous and induced tumors of the lymphoma and sarcoma types|A|T|27|39.0|Non-synonymous|Unprocessed|APF-G1
1530145|IGL00672|1|120606938|F->L||1.0|Probably damaging||deleterious|MGI:95389|En1|engrailed 1 [Source:MGI Symbol;Acc:MGI:95389]|Heterozygous|Mutant homozygotes usually die within 24 hours of birth. Mutants exhibit nervous system defects, including a lack of most of the colliculi, cerebellum, and the third and fourth cranial nerves in some lines. Skeletal anomalies have also been described.|T|C|25|34.0|Non-synonymous|Unprocessed|APF-G1
1530146|IGL00672|4|59719697|S->G|||N/A|0.08|tolerated|MGI:2442164|E130308a19rik|RIKEN cDNA E130308A19 gene [Source:MGI Symbol;Acc:MGI:2442164]|Heterozygous||A|G|25|39.0|Non-synonymous|Unprocessed|APF-G1
1530147|IGL00672|15|82346183|V->I||0.1|Benign|0.44|tolerated|MGI:1916279|1500032l24rik|RIKEN cDNA 1500032L24 gene [Source:MGI Symbol;Acc:MGI:1916279]|Heterozygous||G|A|23|35.0|Non-synonymous|Unprocessed|APF-G1
1530148|IGL00672|9|114515830|V->A||0.98|Probably damaging||deleterious|MGI:2685973|Trim71|tripartite motif-containing 71 [Source:MGI Symbol;Acc:MGI:2685973]|Heterozygous||A|G|22|37.0|Non-synonymous|Unprocessed|APF-G1
1530149|IGL00672|5|110212244|L->S||1.0|Probably damaging|0.02|deleterious|MGI:96958|Golga3|golgi autoantigen, golgin subfamily a, 3 [Source:MGI Symbol;Acc:MGI:96958]|Heterozygous|Males homozygous for a hypomorphic transgenic insertional mutation exhibit impaired spermatogenesis involving loss of pachytene spermatocytes and are usually sterile.|T|C|20|40.0|Non-synonymous|Unprocessed|APF-G1
1530150|IGL00672|7|27661601|K->E||0.81|Possibly damaging|0.11|tolerated|MGI:1346879|Map3k10|mitogen-activated protein kinase kinase kinase 10 [Source:MGI Symbol;Acc:MGI:1346879]|Heterozygous|Mice homozygous for a null allele exhibit normal development, reproduction and lifespan.|T|C|20|35.5|Non-synonymous|Unprocessed|APF-G1
1530151|IGL00672|10|81242085|S->P||0.77|Possibly damaging|0.43|tolerated|MGI:2143792|Zfr2|zinc finger RNA binding protein 2 [Source:MGI Symbol;Acc:MGI:2143792]|Heterozygous||T|C|18|37.0|Non-synonymous|Unprocessed|APF-G1
1530152|IGL00672|18|4674835|S->P||0.01|Benign|0.19|tolerated|MGI:2685174|9430020k01rik|RIKEN cDNA 9430020K01 gene [Source:MGI Symbol;Acc:MGI:2685174]|Heterozygous||T|C|18|38.0|Non-synonymous|Unprocessed|APF-G1
1530153|IGL00672|7|24333610|T->A||0.25|Benign|0.02|deleterious|MGI:1916551|1700008p20rik|RIKEN cDNA 1700008P20 gene [Source:MGI Symbol;Acc:MGI:1916551]|Heterozygous||T|C|17|35.0|Non-synonymous|Unprocessed|APF-G1
1530154|IGL00672|2|132530548|Disrupted splicing|||N/A|||MGI:104898|Gpcpd1|glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:104898]|Heterozygous||G|T|105|40.0|Splice|Unprocessed|APF-G1
1530155|IGL00672|9|50746436|Disrupted splicing|||N/A|||MGI:1914202|2310030g06rik|RIKEN cDNA 2310030G06 gene [Source:MGI Symbol;Acc:MGI:1914202]|Heterozygous||A|G|62|35.0|Splice|Unprocessed|APF-G1
1530156|IGL00672|1|36438834|Disrupted splicing|||N/A|||MGI:2443010|Lman2l|lectin, mannose-binding 2-like [Source:MGI Symbol;Acc:MGI:2443010]|Heterozygous||T|A|35|41.0|Splice|Unprocessed|APF-G1
1530157|IGL00672|5|96759450|Disrupted splicing|||N/A|||MGI:2385368|Fras1|Fraser syndrome 1 homolog (human) [Source:MGI Symbol;Acc:MGI:2385368]|Heterozygous|Mice homozygous for mutations at this locus display a significant amount of embryonic lethality due to hemorrhaging of embryonic blisters.  Survival is variable on genetic backgrounds.  Kidney development is severely affected and syndactyly is common.|T|C|16|39.0|Splice|Unprocessed|APF-G1
1530715|IGL00673|7|141143125|C->F||0.08|Benign|0.04|deleterious|MGI:1351664|Ptdss2|phosphatidylserine synthase 2 [Source:MGI Symbol;Acc:MGI:1351664]|Heterozygous|Disruption of this gene causes infertility in about 10% of homozygous males.  The remaining males and all females were fertile.|G|T|102|40.0|Non-synonymous|Unprocessed|APF-G1
1530716|IGL00673|7|18427891|V->A||0.99|Probably damaging|0.03|deleterious|MGI:1891360|Psg28|pregnancy-specific glycoprotein 28 [Source:MGI Symbol;Acc:MGI:1891360]|Heterozygous||A|G|72|39.0|Non-synonymous|Unprocessed|APF-G1
1530717|IGL00673|15|65995271|T->M||1.0|Probably damaging||deleterious|MGI:1336181|Kcnq3|potassium voltage-gated channel, subfamily Q, member 3 [Source:MGI Symbol;Acc:MGI:1336181]|Heterozygous|Mice homozygous for a null allele exhibit abnormal apamin-insensitive afterhyperpolarization currents in granule cells, but not pyramidal cells, of the hippocampus.  Mice homozygous for a knock-in allele exhibit spontaneous seizures and premature death.|G|A|65|37.0|Non-synonymous|Unprocessed|APF-G1
1530718|IGL00673|11|104528435|Y->H||0.92|Possibly damaging|0.38|tolerated|MGI:102685|Cdc27|cell division cycle 27 homolog (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:102685]|Heterozygous||A|G|56|37.5|Non-synonymous|Unprocessed|APF-G1
1530719|IGL00673|6|142376921|N->I||0.39|Benign|0.04|deleterious|MGI:103021|Recql|RecQ protein-like [Source:MGI Symbol;Acc:MGI:103021]|Heterozygous|Homozygous mutation of this gene results in chromosomal instability, with embryonic fibroblasts exhibiting aneuploidy, spontaneous chromosomal breakage, frequent translocation events, increased sensitivity to ionizing radiation, and increased frequency of sister chromatid exchange.|T|A|44|40.0|Non-synonymous|Unprocessed|APF-G1
1530720|IGL00673|5|7305211|I->F||1.0|Probably damaging||deleterious|MGI:1918170|4921511h03rik|RIKEN cDNA 4921511H03 gene [Source:MGI Symbol;Acc:MGI:1918170]|Heterozygous||A|T|35|38.0|Non-synonymous|Unprocessed|APF-G1
1530721|IGL00673|13|27808453|S->P||1.0|Probably damaging|0.28|tolerated|MGI:1861446|Prl2a1|prolactin family 2, subfamily a, member 1 [Source:MGI Symbol;Acc:MGI:1861446]|Heterozygous||T|C|33|38.0|Non-synonymous|Unprocessed|APF-G1
1530722|IGL00673|18|10582078|F->L||0.92|Possibly damaging|0.04|deleterious|MGI:1925055|Esco1|establishment of cohesion 1 homolog 1 (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1925055]|Heterozygous||A|G|28|39.0|Non-synonymous|Unprocessed|APF-G1
1530723|IGL00673|2|30367717|M->R||0.12|Benign|0.05|tolerated|MGI:1922035|Fam73b|family with sequence similarity 73, member B [Source:MGI Symbol;Acc:MGI:1922035]|Heterozygous||T|G|28|37.0|Non-synonymous|Unprocessed|APF-G1
1530724|IGL00673|12|91234191|H->Q||0.11|Benign|0.35|tolerated|MGI:1922466|4930534b04rik|RIKEN cDNA 4930534B04 gene [Source:MGI Symbol;Acc:MGI:1922466]|Heterozygous||G|T|27|38.0|Non-synonymous|Unprocessed|APF-G1
1530725|IGL00673|2|55595272|D->Y||0.51|Possibly damaging||deleterious|MGI:104742|Kcnj3|potassium inwardly-rectifying channel, subfamily J, member 3 [Source:MGI Symbol;Acc:MGI:104742]|Heterozygous|Mice homozygous for a targeted null mutation display slightly increased resting heart rates, and blunted responses to both indirect vagal activation and direct adenosine A1 receptor activation (intended to activate the muscarinic-gated atrial potassium channel).|G|T|26|38.0|Non-synonymous|Unprocessed|APF-G1
1530726|IGL00673|7|24752017|F->Y||0.83|Possibly damaging|0.17|tolerated|MGI:1916141|Cd177|CD177 antigen [Source:MGI Symbol;Acc:MGI:1916141]|Heterozygous||A|T|23|38.0|Non-synonymous|Unprocessed|APF-G1
1530727|IGL00673|12|78829799|R->S||0.98|Probably damaging||deleterious|MGI:1927339|Mpp5|membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) [Source:MGI Symbol;Acc:MGI:1927339]|Heterozygous|Mice homozygous for a floxed allele activated in cortical neuron exhibit loss of cortex neurons due to premature differentiation and increased apoptosis. These mice also exhibit behavioral defects but are otherwise viable and fertile. Heterozygous mice exhibit an intermediate phenotype.|C|A|22|38.5|Non-synonymous|Unprocessed|APF-G1
1530728|IGL00673|2|70745516|Q->K||0.03|Benign|0.44|tolerated|MGI:2441683|Tlk1|tousled-like kinase 1 [Source:MGI Symbol;Acc:MGI:2441683]|Heterozygous||G|T|22|41.0|Non-synonymous|Unprocessed|APF-G1
1530729|IGL00673|14|37085528|V->A||0.81|Possibly damaging|0.03|deleterious|MGI:2157782|Cdhr1|cadherin-related family member 1 [Source:MGI Symbol;Acc:MGI:2157782]|Heterozygous|Mice homozygous for a targeted null mutation exhibit progressive degeneration of retinal photoreceptor cells and a slight reduction in light responses.|A|G|18|40.0|Non-synonymous|Unprocessed|APF-G1
1530730|IGL00673|18|10798490|S->G|||Benign|0.37|tolerated|MGI:2443157|Mib1|mindbomb homolog 1 (Drosophila) [Source:MGI Symbol;Acc:MGI:2443157]|Heterozygous|Homozygous null mice display embryonic lethality during organogenesis, failure of heart looping, impaired angiogenesis and arterial specification, premature neuronal precursor differentiation, posterior truncation, and abnormal somitogenesis with loss of posterior markers.|A|G|18|39.0|Non-synonymous|Unprocessed|APF-G1
1530731|IGL00673|4|47472329|D->N||0.96|Probably damaging|0.4|tolerated|MGI:1914731|Alg2|asparagine-linked glycosylation 2 homolog (yeast, alpha-1,3-mannosyltransferase) [Source:MGI Symbol;Acc:MGI:1914731]|Heterozygous||C|T|18|38.0|Non-synonymous|Unprocessed|APF-G1
1530732|IGL00673|1|140596051|N->K||0.6|Possibly damaging|0.02|deleterious|MGI:3036273|Kcnt2|potassium channel, subfamily T, member 2 [Source:MGI Symbol;Acc:MGI:3036273]|Heterozygous||T|G|17|40.0|Non-synonymous|Unprocessed|APF-G1
1530733|IGL00673|9|90193661|S->P||0.28|Benign|0.28|tolerated|MGI:1347346|Adamts7|a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 7 [Source:MGI Symbol;Acc:MGI:1347346]|Heterozygous||T|C|17|39.0|Non-synonymous|Unprocessed|APF-G1
1530734|IGL00673|2|120102220|S->P||1.0|Probably damaging||deleterious|MGI:1919619|Ehd4|EH-domain containing 4 [Source:MGI Symbol;Acc:MGI:1919619]|Heterozygous|Mice homozygous for a knock-out allele exhibit reduced male fertility.|A|G|16|39.5|Non-synonymous|Unprocessed|APF-G1
1530735|IGL00673|14|123846432|Disrupted splicing|||N/A|||MGI:2443439|Itgbl1|integrin, beta-like 1 [Source:MGI Symbol;Acc:MGI:2443439]|Heterozygous||C|T|35|40.0|Splice|Unprocessed|APF-G1
1531234|IGL00674|15|58108386|Q->L||0.04|Benign|0.19|tolerated|MGI:1917722|Atad2|ATPase family, AAA domain containing 2 [Source:MGI Symbol;Acc:MGI:1917722]|Heterozygous||T|A|124|40.0|Non-synonymous|Unprocessed|APF-G1
1531235|IGL00674|14|31118776|P->S|||N/A|0.02|deleterious|MGI:1923998|Pbrm1|polybromo 1 [Source:MGI Symbol;Acc:MGI:1923998]|Heterozygous|Homozygous null mice display embryonic lethality with hypoplastic cardiac ventricular chambers and malformation of the placenta.|C|T|103|37.0|Non-synonymous|Unprocessed|APF-G1
1531236|IGL00674|5|3849773|I->T|||Benign|1.0|tolerated|MGI:3045299|4932412h11rik|RIKEN cDNA 4932412H11 gene [Source:MGI Symbol;Acc:MGI:3045299]|Heterozygous||T|C|67|39.0|Non-synonymous|Unprocessed|APF-G1
1531237|IGL00674|2|117177858|P->L||1.0|Probably damaging||deleterious|MGI:2150016|Spred1|sprouty protein with EVH-1 domain 1, related sequence [Source:MGI Symbol;Acc:MGI:2150016]|Heterozygous|Homozygous null mice display increased airway hyperresponsiveness, eosinophilia, a kinked tail, shortened face, impaired spatial learning and memory, and altered CNS transmission.|C|T|54|40.0|Non-synonymous|Unprocessed|APF-G1
1531238|IGL00674|8|127388678|N->D||1.0|Probably damaging|0.03|deleterious|MGI:2135608|Pard3|par-3 (partitioning defective 3) homolog (C. elegans) [Source:MGI Symbol;Acc:MGI:2135608]|Heterozygous|Mice homozygous for a null allele exhibit embryonic lethality at E12.5 associated with growth retardation, abnormal heart development, and abnormal epicardial cell development.|A|G|44|39.5|Non-synonymous|Unprocessed|APF-G1
1531239|IGL00674|9|4329949|T->A||0.09|Benign|0.08|tolerated|MGI:1916399|Kbtbd3|kelch repeat and BTB (POZ) domain containing 3 [Source:MGI Symbol;Acc:MGI:1916399]|Heterozygous||A|G|43|41.0|Non-synonymous|Unprocessed|APF-G1
1531240|IGL00674|4|155808584|F->L|||Benign|0.75|tolerated|MGI:2137221|Mrpl20|mitochondrial ribosomal protein L20 [Source:MGI Symbol;Acc:MGI:2137221]|Heterozygous||T|C|36|36.5|Non-synonymous|Unprocessed|APF-G1
1531241|IGL00674|2|180150258|Y->H||0.99|Probably damaging|0.08|tolerated|MGI:2442832|Osbpl2|oxysterol binding protein-like 2 [Source:MGI Symbol;Acc:MGI:2442832]|Heterozygous||T|C|35|39.0|Non-synonymous|Unprocessed|APF-G1
1531242|IGL00674|17|42808785|N->K||0.84|Possibly damaging|0.11|tolerated|MGI:1330281|Cd2ap|CD2-associated protein [Source:MGI Symbol;Acc:MGI:1330281]|Heterozygous|Homozygotes for a targeted null mutation exhibit impaired immune function and die at 6 to 7 weeks of age from kidney failure associated with podocyte defects and mesangial cell hyperplasia. Heterozygotes develop glomerular changes around 9 months.|A|T|33|41.0|Non-synonymous|Unprocessed|APF-G1
1531243|IGL00674|1|184912106|G->S|||Benign|0.74|tolerated|MGI:2664902|Mark1|MAP/microtubule affinity-regulating kinase 1 [Source:MGI Symbol;Acc:MGI:2664902]|Heterozygous||C|T|30|37.5|Non-synonymous|Unprocessed|APF-G1
1531244|IGL00674|5|118095593|M->I||0.1|Benign|0.34|tolerated|MGI:1923041|Fbxw8|F-box and WD-40 domain protein 8 [Source:MGI Symbol;Acc:MGI:1923041]|Heterozygous|Mice homozygous for a null allele display partial late embryonic lethality with embryonic growth retardation and abnormal placental morphology.|C|T|24|37.0|Non-synonymous|Unprocessed|APF-G1
1531245|IGL00674|5|64980004|S->T||0.03|Benign|0.23|tolerated|MGI:1915553|Fam114a1|family with sequence similarity 114, member A1 [Source:MGI Symbol;Acc:MGI:1915553]|Heterozygous||T|A|22|38.5|Non-synonymous|Unprocessed|APF-G1
1531246|IGL00674|2|168755780|D->G||0.81|Possibly damaging|0.51|tolerated|MGI:2139360|Sall4|sal-like 4 (Drosophila) [Source:MGI Symbol;Acc:MGI:2139360]|Heterozygous|Homozygous mutation of this gene results in early embryonic lethality before somite formation. Heterozygous mutation of this locus causes variable phenotypes, from heart and digit defects to deafness, anogenital tract defects, cranial and carpal bone defects and renal agenesis or hypoplasia.|T|C|19|37.0|Non-synonymous|Unprocessed|APF-G1
1531247|IGL00674|4|63965607|D->V||0.99|Probably damaging|0.01|deleterious|MGI:101922|Tnc|tenascin C [Source:MGI Symbol;Acc:MGI:101922]|Heterozygous|Mice homozygous for several different targeted mutations show variable behavioral and nervous system phenotypes such as abnormal circadian rhythm, anxiety behavior, novelty-induced activity, swimming, impaired synaptic plasticity, long term potentiation and serotonin and dopamine neurotransmission.|T|A|16|38.0|Non-synonymous|Unprocessed|APF-G1
1531248|IGL00674|4|106372679|Disrupted splicing|||N/A|||MGI:1919936|Usp24|ubiquitin specific peptidase 24 [Source:MGI Symbol;Acc:MGI:1919936]|Heterozygous||T|A|85|39.0|Splice|Unprocessed|APF-G1
1531249|IGL00674|13|27159131|Disrupted splicing|||N/A|||MGI:2660938|Prl3d3|prolactin family 3, subfamily d, member 3 [Source:MGI Symbol;Acc:MGI:2660938]|Heterozygous||T|C|50|40.0|Splice|Unprocessed|APF-G1
1531250|IGL00674|13|21313808|Disrupted splicing|||N/A|||MGI:1922762|Gpx6|glutathione peroxidase 6 [Source:MGI Symbol;Acc:MGI:1922762]|Heterozygous||A|G|28|39.0|Splice|Unprocessed|APF-G1
1531251|IGL00674|9|107604041|Disrupted splicing|||N/A|||MGI:107561|Sema3b|sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B [Source:MGI Symbol;Acc:MGI:107561]|Heterozygous|Mice homozygous for one knock-out allele are viable and fertile with no obvious pathological abnormalities. Mice homozygous for a second knock-out allele exhibit improper positioning of a major brain commissural projection, the anterior commissure.|A|C|25|37.0|Splice|Unprocessed|APF-G1
1531252|IGL00674|4|63734246|Disrupted splicing|||N/A|||MGI:2180140|Tnfsf15|tumor necrosis factor (ligand) superfamily, member 15 [Source:MGI Symbol;Acc:MGI:2180140]|Heterozygous|Homozygous targeted mutants display decreased clinical severity in experimental autoimmune encephalomyelitis (EAE).|A|G|19|40.0|Splice|Unprocessed|APF-G1
1531253|IGL00674|11|100432909|Disrupted splicing|||N/A|||MGI:1915356|Nt5c3l|5'-nucleotidase, cytosolic III-like [Source:MGI Symbol;Acc:MGI:1915356]|Heterozygous||A|T|17|37.0|Splice|Unprocessed|APF-G1
1531766|IGL00675|11|110304985|D->E||1.0|Probably damaging|1.0|tolerated|MGI:2386607|Abca5|ATP-binding cassette, sub-family A (ABC1), member 5 [Source:MGI Symbol;Acc:MGI:2386607]|Heterozygous|Mice homozygous for a knock-out allele exhibit exophthalmos, tremors and collapse of the thyroid gland, and develop a dilated cardiomyopathy with large thrombi due to depression of the cardiac function. Severe edema, liver injury and premature death appear to be sensitive to genetic background.|A|T|105|40.0|Non-synonymous|Unprocessed|APF-G1
1531767|IGL00675|7|20023186|I->K||0.43|Benign||deleterious|MGI:2675377|Nlrp9b|NLR family, pyrin domain containing 9B [Source:MGI Symbol;Acc:MGI:2675377]|Heterozygous||T|A|63|40.0|Non-synonymous|Unprocessed|APF-G1
1531768|IGL00675|15|38018284|V->I||0.44|Possibly damaging|0.65|tolerated|MGI:1918040|Ubr5|ubiquitin protein ligase E3 component n-recognin 5 [Source:MGI Symbol;Acc:MGI:1918040]|Heterozygous|Homozygous null mice display embryonic lethality during organogenesis, impaired growth of the allantois, failure or impairment of chorioallantoic fusion, impaired angiogenesis in the yolk sac and allantois, decreased cell proliferation, and increased apoptosis.|C|T|44|41.0|Non-synonymous|Unprocessed|APF-G1
1531769|IGL00675|16|15787158|L->P||0.09|Benign|0.15|tolerated|MGI:104779|Prkdc|protein kinase, DNA activated, catalytic polypeptide [Source:MGI Symbol;Acc:MGI:104779]|Heterozygous|Mutations at this locus effect genome stability, radiation sensitivity and DNA repair. Nonsense (scid) and null homozygotes have severe combined immunodeficiency. A BALB/c variant allele reduces enzyme activity and predisposes to breast cancer.|T|C|44|41.0|Non-synonymous|Unprocessed|APF-G1
1531770|IGL00675|8|34167808|S->T|||Benign|1.0|tolerated|MGI:1915137|Tmem66|transmembrane protein 66 [Source:MGI Symbol;Acc:MGI:1915137]|Heterozygous||T|A|35|37.0|Non-synonymous|Unprocessed|APF-G1
1531771|IGL00675|10|23867168|K->N||0.2|Benign|0.36|tolerated|MGI:1347055|Vnn3|vanin 3 [Source:MGI Symbol;Acc:MGI:1347055]|Heterozygous||G|T|34|41.0|Non-synonymous|Unprocessed|APF-G1
1531772|IGL00675|18|20391918|L->Stop|||N/A|||MGI:2664357|Dsg1b|desmoglein 1 beta [Source:MGI Symbol;Acc:MGI:2664357]|Heterozygous||T|A|27|37.0|Non-synonymous|Unprocessed|APF-G1
1531773|IGL00675|11|50300996|S->P||0.06|Benign|0.15|tolerated|MGI:88261|Canx|calnexin [Source:MGI Symbol;Acc:MGI:88261]|Heterozygous|Homozygotes for a targeted null mutation exhibit motor defects, loss of large myelinated nerve fibers, small size, and very high mortality between birth and 4 weeks of age.|A|G|22|36.5|Non-synonymous|Unprocessed|APF-G1
1531774|IGL00675|15|84200375|S->F||1.0|Probably damaging||deleterious|MGI:1915903|Samm50|sorting and assembly machinery component 50 homolog (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1915903]|Heterozygous||C|T|22|38.5|Non-synonymous|Unprocessed|APF-G1
1531775|IGL00675|3|98111675|Y->H||0.02|Benign|0.07|tolerated|MGI:97364|Notch2|Notch gene homolog 2 (Drosophila) [Source:MGI Symbol;Acc:MGI:97364]|Heterozygous||T|C|21|36.0|Non-synonymous|Unprocessed|APF-G1
1531776|IGL00675|8|25851849|E->G|||N/A|0.42|tolerated|MGI:1202300|Kcnu1|potassium channel, subfamily U, member 1 [Source:MGI Symbol;Acc:MGI:1202300]|Heterozygous|Homozygous male mutants are infertile with impaird sperm capacitation.|A|G|21|39.0|Non-synonymous|Unprocessed|APF-G1
1531777|IGL00675|15|13041439|D->G||1.0|Probably damaging||deleterious|MGI:107435|Cdh6|cadherin 6 [Source:MGI Symbol;Acc:MGI:107435]|Heterozygous|Mice homozygous for a null allele exhibit delayed mesenchyme to epithelial conversion and loss of nephrons.|T|C|16|39.5|Non-synonymous|Unprocessed|APF-G1
1531778|IGL00675|6|142664621|F->L||1.0|Probably damaging|0.02|deleterious|MGI:1352630|Abcc9|ATP-binding cassette, sub-family C (CFTR/MRP), member 9 [Source:MGI Symbol;Acc:MGI:1352630]|Heterozygous|Mice homozygous for disruptions in this gene display lower serum glucose, enhanced insulin action, growth retardation, hypertension and spontaneous death starting at 6 weeks of age due to episodic coronary artery vasospasm.|A|G|16|38.0|Non-synonymous|Unprocessed|APF-G1
1531779|IGL00675|9|58019313|G->W||1.0|Probably damaging||deleterious|MGI:88582|Cyp11a1|cytochrome P450, family 11, subfamily a, polypeptide 1 [Source:MGI Symbol;Acc:MGI:88582]|Heterozygous|Homozygous null mice are exhibit a steroid deficiency and die within days of birth showing signs of dehydration. Males are feminized with female external genitalia and underdeveloped gonads.|G|T|16|37.5|Non-synonymous|Unprocessed|APF-G1
1531780|IGL00675|16|16333827|Disrupted splicing|||N/A|||MGI:1921256|Dnm1l|dynamin 1-like [Source:MGI Symbol;Acc:MGI:1921256]|Heterozygous|Mice homozygous for a knock-out allele exhibit embryonic lethality at E11.5 with internal hemorrhage and small size. Mice heterozygous for an ENU induced allele have dilated cardiomyopathy and congestive heart failure, homozygous are embryonic lethal with posterior truncation at E11.5.|A|G|28|41.0|Splice|Unprocessed|APF-G1
1531781|IGL00675|17|27876917|Disrupted splicing|||N/A|||MGI:3041238|Uhrf1bp1|UHRF1 (ICBP90) binding protein 1 [Source:MGI Symbol;Acc:MGI:3041238]|Heterozygous||C|T|28|39.0|Splice|Unprocessed|APF-G1
1531782|IGL00675|14|20716901|Disrupted splicing|||N/A|||MGI:1919156|2310021p13rik|RIKEN cDNA 2310021P13 gene [Source:MGI Symbol;Acc:MGI:1919156]|Heterozygous||T|C|25|40.0|Splice|Unprocessed|APF-G1
1531783|IGL00675|12|75114189|Disrupted splicing|||N/A|||MGI:3584508|Kcnh5|potassium voltage-gated channel, subfamily H (eag-related), member 5 [Source:MGI Symbol;Acc:MGI:3584508]|Heterozygous||A|T|20|40.0|Splice|Unprocessed|APF-G1
1532275|IGL00676|5|86831811|V->D||1.0|Probably damaging||deleterious|MGI:2443713|Ythdc1|YTH domain containing 1 [Source:MGI Symbol;Acc:MGI:2443713]|Heterozygous||T|A|125|39.0|Non-synonymous|Unprocessed|APF-G1
1532276|IGL00676|12|73971913|D->V||0.98|Probably damaging||deleterious|MGI:1922877|Snapc1|small nuclear RNA activating complex, polypeptide 1 [Source:MGI Symbol;Acc:MGI:1922877]|Heterozygous||A|T|83|39.0|Non-synonymous|Unprocessed|APF-G1
1532277|IGL00676|2|132554011|S->F||1.0|Probably damaging|0.08|tolerated|MGI:104898|Gpcpd1|glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:104898]|Heterozygous||G|A|53|41.0|Non-synonymous|Unprocessed|APF-G1
1532278|IGL00676|13|100152632|N->D||1.0|Probably damaging|0.15|tolerated|MGI:1298226|Naip2|NLR family, apoptosis inhibitory protein 2 [Source:MGI Symbol;Acc:MGI:1298226]|Heterozygous||T|C|48|39.5|Non-synonymous|Unprocessed|APF-G1
1532279|IGL00676|2|62290001|C->F||1.0|Probably damaging|0.03|deleterious|MGI:2150150|Slc4a10|solute carrier family 4, sodium bicarbonate cotransporter-like, member 10 [Source:MGI Symbol;Acc:MGI:2150150]|Heterozygous|Mice with homozygous disruption of this gene exhibit reduced brain ventricle volume, reduced neuronal excitability, impaired pH regulation of neurons, and increased threshold to induced seizures.|G|T|28|38.0|Non-synonymous|Unprocessed|APF-G1
1532280|IGL00676|2|118630138|H->R|||Benign|0.6|tolerated|MGI:1333889|Bub1b|budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1333889]|Heterozygous|Homozygous mutant embryos undergo extensive apoptosis and die during early gestation. Heterozygous mice are viable and exhibit splenomegaly, abnormal megakaryopoiesis, and an increased susceptibility to intestinal tumorigenesis. Hypomorphic homozygotes display infertility and premature aging.|A|G|25|37.0|Non-synonymous|Unprocessed|APF-G1
1532281|IGL00676|4|34807827|I->S||0.99|Probably damaging|0.01|deleterious|MGI:1353423|Zfp292|zinc finger protein 292 [Source:MGI Symbol;Acc:MGI:1353423]|Heterozygous||A|C|24|41.0|Non-synonymous|Unprocessed|APF-G1
1532282|IGL00676|8|71913827|E->G|||Benign|0.06|tolerated|MGI:3642748|Zfp882|zinc finger protein 882 [Source:MGI Symbol;Acc:MGI:3642748]|Heterozygous||A|G|23|40.0|Non-synonymous|Unprocessed|APF-G1
1532283|IGL00676|13|116303053|D->G|||Benign|0.38|tolerated|MGI:101791|Isl1|ISL1 transcription factor, LIM/homeodomain [Source:MGI Symbol;Acc:MGI:101791]|Heterozygous|Homozygotes for a targeted null mutation fail to develop motor neurons and die by embryonic day 11.5. They also show abnormal heart development with absence of heart looping, outflow tract, and the right ventricle and show abnormal pancreas development.|T|C|19|38.0|Non-synonymous|Unprocessed|APF-G1
1532284|IGL00676|17|57192562|T->A||1.0|Probably damaging|0.03|deleterious|MGI:1355317|Tnfsf14|tumor necrosis factor (ligand) superfamily, member 14 [Source:MGI Symbol;Acc:MGI:1355317]|Heterozygous||T|C|17|39.0|Non-synonymous|Unprocessed|APF-G1
1532285|IGL00676|6|87015599|P->Q||1.0|Probably damaging||deleterious|MGI:1913290|Nfu1|NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1913290]|Heterozygous||C|A|17|41.0|Non-synonymous|Unprocessed|APF-G1
1532286|IGL00676|8|123906298|Disrupted splicing|||N/A|||MGI:2442620|Nup133|nucleoporin 133 [Source:MGI Symbol;Acc:MGI:2442620]|Heterozygous|Mice homozygous for an ENU-induced allele exhibit embryonic lethality prior to E10.5, abnormal somitogenesis, pericardial edema, growth retardation, and abnormal neural development.|T|G|31|39.0|Splice|Unprocessed|APF-G1
1532287|IGL00676|8|94137276|Disrupted splicing|||N/A|||MGI:99692|Mt4|metallothionein 4 [Source:MGI Symbol;Acc:MGI:99692]|Heterozygous||A|G|19|40.0|Splice|Unprocessed|APF-G1
1532762|IGL00677|8|107170416|D->G|||Benign|0.37|tolerated|MGI:1913677|Cyb5b|cytochrome b5 type B [Source:MGI Symbol;Acc:MGI:1913677]|Heterozygous||A|G|85|40.0|Non-synonymous|Unprocessed|APF-G1
1532763|IGL00677|13|100316017|R->C||0.02|Benign|0.16|tolerated|MGI:1298222|Naip6|NLR family, apoptosis inhibitory protein 6 [Source:MGI Symbol;Acc:MGI:1298222]|Heterozygous||G|A|80|40.0|Non-synonymous|Unprocessed|APF-G1
1532764|IGL00677|12|70026860|K->I||1.0|Probably damaging|0.01|deleterious|MGI:105108|Nin|ninein [Source:MGI Symbol;Acc:MGI:105108]|Heterozygous||T|A|75|40.0|Non-synonymous|Unprocessed|APF-G1
1532765|IGL00677|13|49531318|E->K||0.01|Benign|0.74|tolerated|MGI:1913586, MGI:3039578|Ecm2,cenpp|extracellular matrix protein 2, female organ and adipocyte specific [Source:MGI Symbol;Acc:MGI:3039578],centromere protein P [Source:MGI Symbol;Acc:MGI:1913586]|Heterozygous||G|A|58|40.0|Non-synonymous|Unprocessed|APF-G1
1532766|IGL00677|1|131356700|M->K||0.01|Benign||deleterious|MGI:109605|Srgap2|SLIT-ROBO Rho GTPase activating protein 2 [Source:MGI Symbol;Acc:MGI:109605]|Heterozygous||A|T|54|40.0|Non-synonymous|Unprocessed|APF-G1
1532767|IGL00677|7|141857894|K->Stop|||N/A|||MGI:1921430|Muc5b|mucin 5, subtype B, tracheobronchial [Source:MGI Symbol;Acc:MGI:1921430]|Heterozygous||A|T|33|39.0|Non-synonymous|Unprocessed|APF-G1
1532768|IGL00677|11|70137106|V->A|||Unknown|||MGI:2385729|Mgl2|macrophage galactose N-acetyl-galactosamine specific lectin 2 [Source:MGI Symbol;Acc:MGI:2385729]|Heterozygous||T|C|18|39.0|Non-synonymous|Unprocessed|APF-G1
1532769|IGL00677|18|22921867|P->T||1.0|Probably damaging|0.27|tolerated|MGI:2441684|Nol4|nucleolar protein 4 [Source:MGI Symbol;Acc:MGI:2441684]|Heterozygous||G|T|16|39.5|Non-synonymous|Unprocessed|APF-G1
1532770|IGL00677|18|44192634|Disrupted splicing|||N/A|||MGI:3588289|Spink11|serine peptidase inhibitor, Kazal type 11 [Source:MGI Symbol;Acc:MGI:3588289]|Heterozygous||C|T|100|40.0|Splice|Unprocessed|APF-G1
1533241|IGL00678|1|6234085|T->A||0.97|Probably damaging||deleterious|MGI:1341850|Rb1cc1|RB1-inducible coiled-coil 1 [Source:MGI Symbol;Acc:MGI:1341850]|Heterozygous|Homozygous mutation of this gene results in embryonic lethality at mid/late gestation associated with heart failure and liver degeneration.|A|G|67|38.0|Non-synonymous|Unprocessed|APF-G1
1533242|IGL00678|1|98496344|S->G||0.01|Benign|1.0|tolerated|MGI:1918116|Slco6d1|solute carrier organic anion transporter family, member 6d1 [Source:MGI Symbol;Acc:MGI:1918116]|Heterozygous||A|G|64|39.5|Non-synonymous|Unprocessed|APF-G1
1533243|IGL00678|7|137452713|V->D||1.0|Probably damaging|0.09|tolerated|MGI:1353653|Glrx3|glutaredoxin 3 [Source:MGI Symbol;Acc:MGI:1353653]|Heterozygous|Mice homozygous for a gene trapped allele exhibit lethality during late organogenesis and early fetal development.  Mice heterozygous for this gene trapped allele exhibit increased response to cardiac injury and decreased cardiac muscle contractility.|T|A|48|39.0|Non-synonymous|Unprocessed|APF-G1
1533244|IGL00678|2|13467710|I->N||0.16|Benign|0.31|tolerated|MGI:1931256|Cubn|cubilin (intrinsic factor-cobalamin receptor) [Source:MGI Symbol;Acc:MGI:1931256]|Heterozygous|Mice homozygous for a null mutation display embryonic lethality during organogenesis, yolk sac and allantoic vasculature defects, embryonic and visceral endoderm defects, and lack somites.  Heterozygotes display incomplete penetrance of premature death.|A|T|27|38.0|Non-synonymous|Unprocessed|APF-G1
1533245|IGL00678|6|132777198|L->Q||0.99|Probably damaging|0.01|deleterious|MGI:2681304|Tas2r136|taste receptor, type 2, member 136 [Source:MGI Symbol;Acc:MGI:2681304]|Heterozygous||A|T|22|39.5|Non-synonymous|Unprocessed|APF-G1
1533246|IGL00678|10|127028442|Q->Stop|||N/A|||MGI:1913649|Tsfm|Ts translation elongation factor, mitochondrial [Source:MGI Symbol;Acc:MGI:1913649]|Heterozygous||G|A|21|41.0|Non-synonymous|Unprocessed|APF-G1
1533247|IGL00678|13|63844613|V->E||1.0|Probably damaging||deleterious|MGI:1923501|0610007p08rik|RIKEN cDNA 0610007P08 gene [Source:MGI Symbol;Acc:MGI:1923501]|Heterozygous||T|A|19|39.0|Non-synonymous|Unprocessed|APF-G1
1533248|IGL00678|2|60006183|E->G|||Unknown||deleterious|MGI:2442782|Baz2b|bromodomain adjacent to zinc finger domain, 2B [Source:MGI Symbol;Acc:MGI:2442782]|Heterozygous||T|C|16|37.5|Non-synonymous|Unprocessed|APF-G1
1533249|IGL00678|4|117564891|H->R||0.08|Benign|0.06|tolerated|MGI:2153887|Eri3|exoribonuclease 3 [Source:MGI Symbol;Acc:MGI:2153887]|Heterozygous||A|G|16|36.5|Non-synonymous|Unprocessed|APF-G1
1533250|IGL00678|7|112841880|Disrupted splicing|||N/A|||MGI:101876|Tead1|TEA domain family member 1 [Source:MGI Symbol;Acc:MGI:101876]|Heterozygous|Mice homozygous for disruptions in this gene die between embryonic day 11 and 12.5.  Abnormalities were seen in heart development.|A|G|90|39.0|Splice|Unprocessed|APF-G1
1533251|IGL00678|5|32485338|Disrupted splicing|||N/A|||MGI:104871|Ppp1cb|protein phosphatase 1, catalytic subunit, beta isoform [Source:MGI Symbol;Acc:MGI:104871]|Heterozygous|Homozygous mutation of this gene results in lethality before weaning.|T|A|51|40.0|Splice|Unprocessed|APF-G1
1533252|IGL00678|1|173594053|Disrupted splicing|||N/A|||MGI:3695276|Pydc4|pyrin domain containing 4 [Source:MGI Symbol;Acc:MGI:3695276]|Heterozygous||A|G|39|39.0|Splice|Unprocessed|APF-G1
1533253|IGL00678|1|191546626|Disrupted splicing|||N/A|||MGI:1924093|Dtl|denticleless homolog (Drosophila) [Source:MGI Symbol;Acc:MGI:1924093]|Heterozygous|Mutation of this gene results in very early embryonic lethality around or before E1.5. In vitro siRNA knockdown experiments show that the gene is essential cell survival and cell cycle progression to allow proper blastocyst formation.|A|C|39|39.0|Splice|Unprocessed|APF-G1
1533254|IGL00678|5|5249237|Disrupted splicing|||N/A|||MGI:894318|Cdk14|cyclin-dependent kinase 14 [Source:MGI Symbol;Acc:MGI:894318]|Heterozygous||T|C|19|37.0|Splice|Unprocessed|APF-G1
1533255|IGL00678|8|94089167|Disrupted splicing|||N/A|||MGI:2135267|Bbs2|Bardet-Biedl syndrome 2 (human) [Source:MGI Symbol;Acc:MGI:2135267]|Heterozygous|Homozygous null mice display obesity associated with polyphagia, retinopathy associated with mislocalization of rhodopsin, cilia defects, renal cysts, male sterility, abnormal brain neuroanatomy, reduced salivation and acoustic startle response, an olfactory deficit and abnormal social interaction.|T|A|17|40.0|Splice|Unprocessed|APF-G1
1533756|IGL00679|17|58055678|D->G||1.0|Probably damaging|0.05|deleterious|MGI:3646013|Cntnap5c|contactin associated protein-like 5C [Source:MGI Symbol;Acc:MGI:3646013]|Heterozygous||A|G|110|40.0|Non-synonymous|Unprocessed|APF-G1
1533757|IGL00679|11|108591053|K->R||1.0|Probably damaging|0.05|deleterious|MGI:1923673|Ccdc46|coiled-coil domain containing 46 [Source:MGI Symbol;Acc:MGI:1923673]|Heterozygous||A|G|92|39.0|Non-synonymous|Unprocessed|APF-G1
1533758|IGL00679|10|41719800|C->Stop|||N/A|||MGI:1915511|Cep57l1|centrosomal protein 57-like 1 [Source:MGI Symbol;Acc:MGI:1915511]|Heterozygous||A|T|47|39.0|Non-synonymous|Unprocessed|APF-G1
1533759|IGL00679|12|52517281|A->D||0.87|Possibly damaging|0.01|deleterious|MGI:1332637|Arhgap5|Rho GTPase activating protein 5 [Source:MGI Symbol;Acc:MGI:1332637]|Heterozygous|Homozygotes die at birth, are 30% smaller, do not inflate their lungs, and show a small thymus, abnormal adipocyte differentiation and brain defects in the corpus callosum, anterior commissure and lateral ventricles. Mutant MEFs show impaired adipogenesis but undergo myogenesis in response to IGF-1.|C|A|39|40.0|Non-synonymous|Unprocessed|APF-G1
1533760|IGL00679|5|142659149|D->G||1.0|Probably damaging|0.04|deleterious|MGI:1923831|Wipi2|WD repeat domain, phosphoinositide interacting 2 [Source:MGI Symbol;Acc:MGI:1923831]|Heterozygous||A|G|39|38.0|Non-synonymous|Unprocessed|APF-G1
1533761|IGL00679|15|94556628|M->K|||Benign|0.04|deleterious|MGI:2182474|Irak4|interleukin-1 receptor-associated kinase 4 [Source:MGI Symbol;Acc:MGI:2182474]|Heterozygous|Homozygous mutant mice exhibit defects of the innate immune system and show increased susceptibility to bacterial infection.|T|A|33|40.0|Non-synonymous|Unprocessed|APF-G1
1533762|IGL00679|9|109161964|P->L||1.0|Probably damaging|0.03|deleterious|MGI:2443323|Fbxw21|F-box and WD-40 domain protein 21 [Source:MGI Symbol;Acc:MGI:2443323]|Heterozygous||G|A|30|41.0|Non-synonymous|Unprocessed|APF-G1
1533763|IGL00679|5|76567023|H->L||1.0|Probably damaging|0.01|deleterious|MGI:2445020|Exoc1|exocyst complex component 1 [Source:MGI Symbol;Acc:MGI:2445020]|Heterozygous||A|T|26|40.0|Non-synonymous|Unprocessed|APF-G1
1533764|IGL00679|8|123827414|D->G||1.0|Probably damaging||deleterious|MGI:105069|Rab4a|RAB4A, member RAS oncogene family [Source:MGI Symbol;Acc:MGI:105069]|Heterozygous||A|G|22|37.5|Non-synonymous|Unprocessed|APF-G1
1533765|IGL00679|2|104994591|P->S||1.0|Probably damaging||deleterious|MGI:3606488|Ccdc73|coiled-coil domain containing 73 [Source:MGI Symbol;Acc:MGI:3606488]|Heterozygous||C|T|19|40.0|Non-synonymous|Unprocessed|APF-G1
1533766|IGL00679|3|108537635|E->G||0.56|Possibly damaging|0.01|deleterious|MGI:1922754|1700013f07rik|RIKEN cDNA 1700013F07 gene [Source:MGI Symbol;Acc:MGI:1922754]|Heterozygous||A|G|19|37.0|Non-synonymous|Unprocessed|APF-G1
1533767|IGL00679|4|116008283|L->Q||0.55|Possibly damaging|0.06|tolerated|MGI:109609|Faah|fatty acid amide hydrolase [Source:MGI Symbol;Acc:MGI:109609]|Heterozygous|Mice homozygous for disruptions in this gene show a normal phenotype.|A|T|19|37.0|Non-synonymous|Unprocessed|APF-G1
1533768|IGL00679|19|4326841|C->S||1.0|Probably damaging||deleterious|MGI:1354736|Kdm2a|lysine (K)-specific demethylase 2A [Source:MGI Symbol;Acc:MGI:1354736]|Heterozygous||A|T|18|39.0|Non-synonymous|Unprocessed|APF-G1
1533769|IGL00679|19|8604855|I->M||0.95|Possibly damaging||deleterious|MGI:1336187|Slc22a8|solute carrier family 22 (organic anion transporter), member 8 [Source:MGI Symbol;Acc:MGI:1336187]|Heterozygous|Mice homozygous for a null allele exhibit decreased urinary urate levels.|A|G|18|39.0|Non-synonymous|Unprocessed|APF-G1
1534278|IGL00684|10|11163037|D->G||0.08|Benign|0.24|tolerated|MGI:1917581|Shprh|SNF2 histone linker PHD RING helicase [Source:MGI Symbol;Acc:MGI:1917581]|Heterozygous||A|G|63|40.0|Non-synonymous|Unprocessed|APF-G1
1534279|IGL00684|5|24182043|A->E||0.82|Possibly damaging|0.1|tolerated|MGI:2387631|Nupl2|nucleoporin like 2 [Source:MGI Symbol;Acc:MGI:2387631]|Heterozygous||C|A|49|37.0|Non-synonymous|Unprocessed|APF-G1
1534280|IGL00684|19|18703382|E->G||0.6|Possibly damaging|0.15|tolerated|MGI:1914633|2410127l17rik|RIKEN cDNA 2410127L17 gene [Source:MGI Symbol;Acc:MGI:1914633]|Heterozygous||A|G|48|41.0|Non-synonymous|Unprocessed|APF-G1
1534281|IGL00684|15|98064838|S->P||0.96|Probably damaging|0.29|tolerated|MGI:2445054|Senp1|SUMO1/sentrin specific peptidase 1 [Source:MGI Symbol;Acc:MGI:2445054]|Heterozygous|Homozygous mutant mice die before birth. Depending on the allele mice may exhibit placental labyrinth defects and widespread cell death or severe anemia and a defect in definitive erythropoiesis in the fetal liver.|A|G|38|39.5|Non-synonymous|Unprocessed|APF-G1
1534282|IGL00684|7|16561700|R->S||0.05|Benign|0.15|tolerated|MGI:1929494|Grlf1|glucocorticoid receptor DNA binding factor 1 [Source:MGI Symbol;Acc:MGI:1929494]|Heterozygous|Mice homozygous for disruptions in this gene usually die within 2 days of birth and never survive beyond 3 weeks.  Abnormalities are seen in the retina and in the development of the brain and nervous system.|G|T|37|38.0|Non-synonymous|Unprocessed|APF-G1
1534283|IGL00684|6|38608176|D->G|||Unknown|0.35|tolerated|MGI:2183260|Luc7l2|LUC7-like 2 (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:2183260]|Heterozygous||A|G|35|40.0|Non-synonymous|Unprocessed|APF-G1
1534284|IGL00684|11|69674093|V->A||0.14|Benign|0.04|deleterious|MGI:2158736|Senp3|SUMO/sentrin specific peptidase 3 [Source:MGI Symbol;Acc:MGI:2158736]|Heterozygous||A|G|31|40.0|Non-synonymous|Unprocessed|APF-G1
1534285|IGL00684|4|108479466|M->T||0.95|Possibly damaging|0.45|tolerated|MGI:2445126|Zcchc11|zinc finger, CCHC domain containing 11 [Source:MGI Symbol;Acc:MGI:2445126]|Heterozygous||T|C|29|40.0|Non-synonymous|Unprocessed|APF-G1
1534286|IGL00684|2|74706766|V->A|||Benign|0.91|tolerated|MGI:96209|Hoxd8|homeobox D8 [Source:MGI Symbol;Acc:MGI:96209]|Heterozygous|Mice homozygous for a knock-out allele are viable and healthy but show minor and low penetrance  homeotic transformations in both lumbar (L1 to T13) and thoracic (T8 to T7) vertebrae.|T|C|26|37.0|Non-synonymous|Unprocessed|APF-G1
1534287|IGL00684|10|5342167|L->Stop|||N/A|||MGI:1927152|Syne1|synaptic nuclear envelope 1 [Source:MGI Symbol;Acc:MGI:1927152]|Heterozygous|Mice homozygous for an allele lacking the KASH domain exhibit neonatal and postnatal lethality, progressive muscular dystrophy, and limb weakness.|T|A|24|40.0|Non-synonymous|Unprocessed|APF-G1
1534288|IGL00684|11|101185092|A->V||0.98|Probably damaging|0.03|deleterious|MGI:1858201|Cntnap1|contactin associated protein-like 1 [Source:MGI Symbol;Acc:MGI:1858201]|Heterozygous|Homozygous mutant mice exhibit reduced body size and nervous system defects, including impaired balance, hypoactivity, and and ataxia.|C|T|17|38.0|Non-synonymous|Unprocessed|APF-G1
1534289|IGL00684|1|58827314|Disrupted splicing|||N/A|||MGI:1261423|Casp8|caspase 8 [Source:MGI Symbol;Acc:MGI:1261423]|Heterozygous|Homozygotes for a targeted null mutation exhibit impaired cardiac muscle development, cardiac erythrocyte congestion, low numbers of colony-forming cells, and prenatal lethality. T-cell restricted knockout mice are viable, but immunodeficient.|T|C|29|41.0|Splice|Unprocessed|APF-G1
1534290|IGL00684|1|87824424|Disrupted splicing|||N/A|||MGI:98227|Sag|retinal S-antigen [Source:MGI Symbol;Acc:MGI:98227]|Heterozygous||A|T|19|40.0|Splice|Unprocessed|APF-G1
1534787|IGL00685|6|132762525|N->S||0.09|Benign|0.18|tolerated|MGI:2681171|Tas2r102|taste receptor, type 2, member 102 [Source:MGI Symbol;Acc:MGI:2681171]|Heterozygous||A|G|88|40.0|Non-synonymous|Unprocessed|APF-G1
1534788|IGL00685|19|38201564|K->N||0.99|Probably damaging|0.06|tolerated|MGI:1917817|5730455o13rik|RIKEN cDNA 5730455O13 gene [Source:MGI Symbol;Acc:MGI:1917817]|Heterozygous||T|A|78|41.0|Non-synonymous|Unprocessed|APF-G1
1534789|IGL00685|3|145127873|N->Y||0.54|Possibly damaging|0.06|tolerated|MGI:1098600|Odf2l|outer dense fiber of sperm tails 2-like [Source:MGI Symbol;Acc:MGI:1098600]|Heterozygous||A|T|60|40.0|Non-synonymous|Unprocessed|APF-G1
1534790|IGL00685|17|88462877|S->P||0.28|Benign|0.18|tolerated|MGI:1347478|Foxn2|forkhead box N2 [Source:MGI Symbol;Acc:MGI:1347478]|Heterozygous||T|C|39|40.0|Non-synonymous|Unprocessed|APF-G1
1534791|IGL00685|4|26340578|L->P||0.99|Probably damaging||deleterious|MGI:2444484|Manea|mannosidase, endo-alpha [Source:MGI Symbol;Acc:MGI:2444484]|Heterozygous||A|G|32|40.0|Non-synonymous|Unprocessed|APF-G1
1534792|IGL00685|6|130182406|I->F||1.0|Probably damaging||deleterious|MGI:1321153|Klra9|killer cell lectin-like receptor subfamily A, member 9 [Source:MGI Symbol;Acc:MGI:1321153]|Heterozygous||T|A|31|35.0|Non-synonymous|Unprocessed|APF-G1
1535210|IGL00686|X|154484132|T->I||0.84|Possibly damaging|0.27|tolerated|MGI:1922435|4930542n07rik|RIKEN cDNA 4930542N07 gene [Source:MGI Symbol;Acc:MGI:1922435]|Heterozygous||C|T|46|41.0|Non-synonymous|Unprocessed|APF-G1
1535211|IGL00686|16|91055601|S->P|||Benign|0.03|deleterious|MGI:1921637|4932438h23rik|RIKEN cDNA 4932438H23 gene [Source:MGI Symbol;Acc:MGI:1921637]|Heterozygous||A|G|28|39.5|Non-synonymous|Unprocessed|APF-G1
1535212|IGL00686|15|71462319|S->P||0.82|Possibly damaging|0.28|tolerated|MGI:1917613|Fam135b|family with sequence similarity 135, member B [Source:MGI Symbol;Acc:MGI:1917613]|Heterozygous||A|G|19|39.0|Non-synonymous|Unprocessed|APF-G1
1535213|IGL00686|4|32641433|D->G||1.0|Probably damaging|0.01|deleterious|MGI:1349399|Casp8ap2|caspase 8 associated protein 2 [Source:MGI Symbol;Acc:MGI:1349399]|Heterozygous||A|G|19|38.0|Non-synonymous|Unprocessed|APF-G1
1535214|IGL00686|X|134559264|Y->H||1.0|Probably damaging||deleterious|MGI:88216|Btk|Bruton agammaglobulinemia tyrosine kinase [Source:MGI Symbol;Acc:MGI:88216]|Heterozygous|Mutants have immune defects including reduced B cell numbers, serum immunoglobulin deficiencies, and defective responses to B cell activators and thymus-independent antigens.  B-1 B cells are absent in these mice.|A|G|18|38.0|Non-synonymous|Unprocessed|APF-G1
1535215|IGL00686|10|82651513|N->Y||0.1|Benign|0.03|deleterious|MGI:1922032|Glt8d2|glycosyltransferase 8 domain containing 2 [Source:MGI Symbol;Acc:MGI:1922032]|Heterozygous||T|A|17|37.0|Non-synonymous|Unprocessed|APF-G1
1535216|IGL00686|7|126825003|Disrupted splicing|||N/A|||MGI:1916202|Fam57b|family with sequence similarity 57, member B [Source:MGI Symbol;Acc:MGI:1916202]|Heterozygous||C|T|17|38.0|Splice|Unprocessed|APF-G1
1535635|IGL00687|8|126382164|F->L|||Benign|1.0|tolerated|MGI:2444426|Slc35f3|solute carrier family 35, member F3 [Source:MGI Symbol;Acc:MGI:2444426]|Heterozygous||T|C|218|39.0|Non-synonymous|Unprocessed|APF-G1
1535636|IGL00687|19|11421318|S->P||1.0|Probably damaging|0.01|deleterious|MGI:1927656|Ms4a4c|membrane-spanning 4-domains, subfamily A, member 4C [Source:MGI Symbol;Acc:MGI:1927656]|Heterozygous||T|C|133|40.0|Non-synonymous|Unprocessed|APF-G1
1535637|IGL00687|5|104310068|E->G|||Unknown|0.06|tolerated|MGI:96389|Ibsp|integrin binding sialoprotein [Source:MGI Symbol;Acc:MGI:96389]|Heterozygous|Mice homozygous for a knock-out allele exhibit reduced body weight/size and impaired long bone growth and mineralization, concomitant with severely reduced bone formation.|A|G|65|38.0|Non-synonymous|Unprocessed|APF-G1
1535638|IGL00687|11|74416259|D->V||0.99|Probably damaging|0.05|deleterious|MGI:3028623|Rap1gap2|RAP1 GTPase activating protein 2 [Source:MGI Symbol;Acc:MGI:3028623]|Heterozygous||T|A|44|38.5|Non-synonymous|Unprocessed|APF-G1
1535639|IGL00687|X|112624811|R->Q||1.0|Probably damaging|0.11|tolerated|MGI:3045342|Zfp711|zinc finger protein 711 [Source:MGI Symbol;Acc:MGI:3045342]|Heterozygous||G|A|42|41.0|Non-synonymous|Unprocessed|APF-G1
1535640|IGL00687|14|75275093|I->M||0.35|Benign|0.08|tolerated|MGI:1891837|Cpb2|carboxypeptidase B2 (plasma) [Source:MGI Symbol;Acc:MGI:1891837]|Heterozygous||A|G|25|39.0|Non-synonymous|Unprocessed|APF-G1
1535641|IGL00687|1|20524070|N->S||0.01|Benign|0.32|tolerated|MGI:2155808|Pkhd1|polycystic kidney and hepatic disease 1 [Source:MGI Symbol;Acc:MGI:2155808]|Heterozygous|Mice homozygous for a mutation in this gene display variable progressive liver cysts and fibrosis, but do not display kidney cysts and are fertile.  Mice homozygous for a hypomorphic and null allele display renal, pancreatic, billiary and liver cysts.|T|C|21|40.0|Non-synonymous|Unprocessed|APF-G1
1535642|IGL00687|5|92065848|E->G||0.28|Benign|0.05|deleterious|MGI:2442040|G3bp2|GTPase activating protein (SH3 domain) binding protein 2 [Source:MGI Symbol;Acc:MGI:2442040]|Heterozygous||T|C|17|40.0|Non-synonymous|Unprocessed|APF-G1
1535643|IGL00687|8|28715813|Disrupted splicing|||N/A|||MGI:2389364|Unc5d|unc-5 homolog D (C. elegans) [Source:MGI Symbol;Acc:MGI:2389364]|Heterozygous||A|T|51|39.0|Splice|Unprocessed|APF-G1
1535644|IGL00687|12|117922004|Disrupted splicing|||N/A|||MGI:1100864|Dnahc11|dynein, axonemal, heavy chain 11 [Source:MGI Symbol;Acc:MGI:1100864]|Heterozygous|Approximately half of live-born homozygous mutants show situs inversus indicating that this gene is no longer properly controlling left-right asymmetry.|T|A|38|39.0|Splice|Unprocessed|APF-G1
1535645|IGL00687|11|101030505|Disrupted splicing|||N/A|||MGI:103286|Atp6v0a1|ATPase, H+ transporting, lysosomal V0 subunit A1 [Source:MGI Symbol;Acc:MGI:103286]|Heterozygous||T|A|17|39.0|Splice|Unprocessed|APF-G1
1536194|IGL00688|15|94566863|H->R||0.19|Benign|0.52|tolerated|MGI:2182474|Irak4|interleukin-1 receptor-associated kinase 4 [Source:MGI Symbol;Acc:MGI:2182474]|Heterozygous|Homozygous mutant mice exhibit defects of the innate immune system and show increased susceptibility to bacterial infection.|A|G|55|39.0|Non-synonymous|Unprocessed|APF-G1
1536195|IGL00688|4|116553474|I->V|||Benign|0.4|tolerated|MGI:3045357|Tmem69|transmembrane protein 69 [Source:MGI Symbol;Acc:MGI:3045357]|Heterozygous||T|C|55|39.0|Non-synonymous|Unprocessed|APF-G1
1536196|IGL00688|9|31389049|D->E||0.14|Benign|0.04|deleterious|MGI:2442410|Nfrkb|nuclear factor related to kappa B binding protein [Source:MGI Symbol;Acc:MGI:2442410]|Heterozygous||T|A|47|39.0|Non-synonymous|Unprocessed|APF-G1
1536197|IGL00688|11|105798690|Y->C||0.99|Probably damaging|0.2|tolerated|MGI:2444121|Tanc2|tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 [Source:MGI Symbol;Acc:MGI:2444121]|Heterozygous|Mice homozygous for a gene trap vector die prior to E12.|A|G|45|38.0|Non-synonymous|Unprocessed|APF-G1
1536198|IGL00688|2|126089445|T->A||0.12|Benign|0.75|tolerated|MGI:1923073, MGI:95521|Fgf7,4930525f21rik|fibroblast growth factor 7 [Source:MGI Symbol;Acc:MGI:95521],RIKEN cDNA 4930525F21 gene [Source:MGI Symbol;Acc:MGI:1923073]|Heterozygous|Mice homozygous for a knock-out allele exhibit abnormal coat appearance, abnormal kidney morphology, spleen hypoplasia, decreased vesicles clustering in GABAergic synapses, decreased miniature inhibitory postsynaptic currents, and increased susceptibility to drug-induced seizures.,NO_PHENOTYPE|A|G|42|38.5|Non-synonymous|Unprocessed|APF-G1
1536199|IGL00688|2|29148445|S->R||0.24|Benign|0.19|tolerated|MGI:2443480|Setx|senataxin [Source:MGI Symbol;Acc:MGI:2443480]|Heterozygous||T|A|38|39.5|Non-synonymous|Unprocessed|APF-G1
1536200|IGL00688|4|143965822|P->Q||0.97|Probably damaging|0.16|tolerated|MGI:3650204|Gm13101|predicted gene 13101 [Source:MGI Symbol;Acc:MGI:3650204]|Heterozygous||G|T|37|41.0|Non-synonymous|Unprocessed|APF-G1
1536201|IGL00688|15|99316131|K->E|||Unknown|0.15|tolerated|MGI:1925583|Prpf40b|PRP40 pre-mRNA processing factor 40 homolog B (yeast) [Source:MGI Symbol;Acc:MGI:1925583]|Heterozygous||A|G|27|41.0|Non-synonymous|Unprocessed|APF-G1
1536202|IGL00688|11|104425066|T->A||1.0|Probably damaging|0.31|tolerated|MGI:1923969|1700081l11rik|RIKEN cDNA 1700081L11 gene [Source:MGI Symbol;Acc:MGI:1923969]|Heterozygous||T|C|26|38.0|Non-synonymous|Unprocessed|APF-G1
1536203|IGL00688|X|101562939|E->G||0.96|Probably damaging|0.29|tolerated|MGI:1336878|Taf1|TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor [Source:MGI Symbol;Acc:MGI:1336878]|Heterozygous||A|G|25|40.0|Non-synonymous|Unprocessed|APF-G1
1536204|IGL00688|4|39451443|L->F||0.03|Benign|0.09|tolerated|MGI:1922721|1700009n14rik|RIKEN cDNA 1700009N14 gene [Source:MGI Symbol;Acc:MGI:1922721]|Heterozygous||A|T|23|39.0|Non-synonymous|Unprocessed|APF-G1
1536205|IGL00688|19|4725938|E->G||1.0|Probably damaging||deleterious|MGI:3054746, MGI:1313261|Spnb3|spectrin beta 3 [Source:MGI Symbol;Acc:MGI:1313261]|Heterozygous|Homozygous hypomorphic mutants exhibit a progressive ataxic phenotype with gait abnormalities, tremor, deteriorating motor coordination, Purkinje cell loss, and cerebellar atrophy (molecular layer thinning) and age-related reduction in simple firing rate in surviving Purkinje cells.|A|G|19|39.0|Non-synonymous|Unprocessed|APF-G1
1536206|IGL00688|2|59815391|L->R||1.0|Probably damaging||deleterious|MGI:1914110|Tanc1|tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 [Source:MGI Symbol;Acc:MGI:1914110]|Heterozygous|Mice homozygous for a gene trap vector exhibit decreased spine density in the CA3 region and impaired spatial memory.|T|G|18|37.5|Non-synonymous|Unprocessed|APF-G1
1536207|IGL00688|12|74898397|K->E||0.99|Probably damaging||deleterious|MGI:3584508|Kcnh5|potassium voltage-gated channel, subfamily H (eag-related), member 5 [Source:MGI Symbol;Acc:MGI:3584508]|Heterozygous||T|C|17|39.0|Non-synonymous|Unprocessed|APF-G1
1536208|IGL00688|18|34349693|S->R|||Benign|0.59|tolerated|MGI:1270152|Reep5|receptor accessory protein 5 [Source:MGI Symbol;Acc:MGI:1270152]|Heterozygous||A|T|17|37.0|Non-synonymous|Unprocessed|APF-G1
1536209|IGL00688|15|10322381|Disrupted splicing|||N/A|||MGI:97763|Prlr|prolactin receptor [Source:MGI Symbol;Acc:MGI:97763]|Heterozygous|Mice homozygous for a knock-out allele exhibit abnormal growth, hormone and glucose homeostasis, hair cycling, female reproductive behavior, morphology, and function, and thyroid, prostate, Hardarian, and lacrimal gland morphologies. Heterozygous mice exhibit defective neuron proliferation.|T|C|55|39.0|Splice|Unprocessed|APF-G1
1536210|IGL00688|2|91686497|Disrupted splicing|||N/A|||MGI:1196429|Atg13|ATG13 autophagy related 13 homolog (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1196429]|Heterozygous||A|T|21|38.0|Splice|Unprocessed|APF-G1
1537198|IGL00690|9|13819016|N->K||0.08|Benign|0.09|tolerated|MGI:1915551|Cep57|centrosomal protein 57 [Source:MGI Symbol;Acc:MGI:1915551]|Heterozygous||A|T|78|39.0|Non-synonymous|Unprocessed|APF-G1
1537199|IGL00690|11|98169400|D->E|||Unknown|1.0|tolerated|MGI:1100846|Med1|mediator complex subunit 1 [Source:MGI Symbol;Acc:MGI:1100846]|Heterozygous|Homozygotes for targeted null mutations have defects of placental vasculature, heart, and lens,  arrested erythrocytic differentiation, impaired neuronal development, and die by embryonic day 11.5.|A|C|62|40.0|Non-synonymous|Unprocessed|APF-G1
1537200|IGL00690|12|104151939|L->M||0.97|Probably damaging|0.12|tolerated|MGI:102848|Serpina3c|serine (or cysteine) peptidase inhibitor, clade A, member 3C [Source:MGI Symbol;Acc:MGI:102848]|Heterozygous||A|T|52|39.0|Non-synonymous|Unprocessed|APF-G1
1537201|IGL00690|15|64699302|V->A|||N/A||deleterious|MGI:1341110|Adcy8|adenylate cyclase 8 [Source:MGI Symbol;Acc:MGI:1341110]|Heterozygous|Homozygous mutation of this gene results in reduced body size (in female animals only), reduced anxiety, and impaired long term depression (LTD).|A|G|44|38.0|Non-synonymous|Unprocessed|APF-G1
1537202|IGL00690|4|143965822|P->Q||0.97|Probably damaging|0.16|tolerated|MGI:3650204|Gm13101|predicted gene 13101 [Source:MGI Symbol;Acc:MGI:3650204]|Heterozygous||G|T|35|41.0|Non-synonymous|Unprocessed|APF-G1
1537203|IGL00690|7|19206143|W->R||0.02|Benign|0.28|tolerated|MGI:1919455|Eml2|echinoderm microtubule associated protein like 2 [Source:MGI Symbol;Acc:MGI:1919455]|Heterozygous||T|A|34|38.5|Non-synonymous|Unprocessed|APF-G1
1537204|IGL00690|2|121235995|I->T||0.92|Possibly damaging|0.67|tolerated|MGI:1351320|Trp53bp1|transformation related protein 53 binding protein 1 [Source:MGI Symbol;Acc:MGI:1351320]|Heterozygous|Homozygous mutations in this gene result in growth retardation, immunodeficiency, thymic hypoplasia, and increased incidence of thymic lymphomas.|A|G|33|39.0|Non-synonymous|Unprocessed|APF-G1
1537205|IGL00690|10|50699943|Q->Stop|||N/A|||MGI:1925237|Ascc3|activating signal cointegrator 1 complex subunit 3 [Source:MGI Symbol;Acc:MGI:1925237]|Heterozygous||C|T|27|36.0|Non-synonymous|Unprocessed|APF-G1
1537206|IGL00690|X|95081679|C->Y||1.0|Probably damaging||deleterious|MGI:2442233|Arhgef9|CDC42 guanine nucleotide exchange factor (GEF) 9 [Source:MGI Symbol;Acc:MGI:2442233]|Heterozygous|Male mice hemizygous for a null allele exhibit impaired spatial learning, increased anxiety-associated behaviors, and altered central nervous system synaptic transmission.|C|T|24|40.0|Non-synonymous|Unprocessed|APF-G1
1537207|IGL00690|16|96017586|Y->H||1.0|Probably damaging|0.12|tolerated|MGI:1890651|Brwd1|bromodomain and WD repeat domain containing 1 [Source:MGI Symbol;Acc:MGI:1890651]|Heterozygous|Homozygous males and females are infertile. Spermiogenesis is impaired; males have low epididymal sperm concentration with low motility and abnormal sperm head morphology. Female oocytes commonly contain vacuoles and have low developmental competence to 2-cell and blastocyst stages.|A|G|22|37.0|Non-synonymous|Unprocessed|APF-G1
1537208|IGL00690|4|120163452|R->H||1.0|Probably damaging||deleterious|MGI:95284|Edn2|endothelin 2 [Source:MGI Symbol;Acc:MGI:95284]|Heterozygous||G|A|22|35.0|Non-synonymous|Unprocessed|APF-G1
1537209|IGL00690|11|80059337|S->P||1.0|Probably damaging|0.06|tolerated|MGI:1860086|Crlf3|cytokine receptor-like factor 3 [Source:MGI Symbol;Acc:MGI:1860086]|Heterozygous||A|G|20|40.0|Non-synonymous|Unprocessed|APF-G1
1537210|IGL00690|14|55832562|F->S||1.0|Probably damaging|0.01|deleterious|MGI:1920431|Nfatc4|nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 [Source:MGI Symbol;Acc:MGI:1920431]|Heterozygous|Mice homozygous for a knock-out allele are viable and overtly normal and exhibit normal embryonic heart morphology as well as normal pathophysiologic cardiac hypertrophy in response to angiotensin II infusion or aortic banding.|T|C|20|35.0|Non-synonymous|Unprocessed|APF-G1
1537211|IGL00690|12|51610438|I->V||0.04|Benign|0.47|tolerated|MGI:2151064|Strn3|striatin, calmodulin binding protein 3 [Source:MGI Symbol;Acc:MGI:2151064]|Heterozygous||T|C|19|40.0|Non-synonymous|Unprocessed|APF-G1
1537212|IGL00690|9|78065016|D->V||0.95|Possibly damaging||deleterious|MGI:108045|Gcm1|glial cells missing homolog 1 (Drosophila) [Source:MGI Symbol;Acc:MGI:108045]|Heterozygous|Homozygotes for targeted null mutations exhibit impaired branching of the chorioallantoic interface, absence of the placental labyrinth, lack of fusion of chorionic trophoblast cells, and lethality between embryonic days 5.5-10.|A|T|16|38.5|Non-synonymous|Unprocessed|APF-G1
1537213|IGL00690|10|61092690|Disrupted splicing|||N/A|||MGI:94873|Pcbd1|pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 1 [Source:MGI Symbol;Acc:MGI:94873]|Heterozygous|Homozygous mutant mice display hyperphenylalaninemia, are mildly glucose intolerant, and are predisposed to cataract formation.|T|C|28|38.0|Splice|Unprocessed|APF-G1
1537214|IGL00690|1|120150606|Disrupted splicing|||N/A|||MGI:1920353|3110009e18rik|RIKEN cDNA 3110009E18 gene [Source:MGI Symbol;Acc:MGI:1920353]|Heterozygous||T|C|24|39.0|Splice|Unprocessed|APF-G1
1537719|IGL00691|3|116779258|Q->K|||N/A|1.0|tolerated|MGI:1924809|Agl|amylo-1,6-glucosidase, 4-alpha-glucanotransferase [Source:MGI Symbol;Acc:MGI:1924809]|Heterozygous||G|T|81|40.0|Non-synonymous|Unprocessed|APF-G1
1537720|IGL00691|5|3863929|I->S||0.96|Probably damaging||deleterious|MGI:3045299|4932412h11rik|RIKEN cDNA 4932412H11 gene [Source:MGI Symbol;Acc:MGI:3045299]|Heterozygous||T|G|62|40.0|Non-synonymous|Unprocessed|APF-G1
1537721|IGL00691|3|152428514|T->K||0.01|Benign|0.48|tolerated|MGI:1920453|Zzz3|zinc finger, ZZ domain containing 3 [Source:MGI Symbol;Acc:MGI:1920453]|Heterozygous||C|A|52|38.0|Non-synonymous|Unprocessed|APF-G1
1537722|IGL00691|15|44627591|I->V||0.97|Probably damaging|0.59|tolerated|MGI:1859920|Ebag9|estrogen receptor-binding fragment-associated gene 9 [Source:MGI Symbol;Acc:MGI:1859920]|Heterozygous|Homozygous null mice have decreased susceptibility to bacterial infections and have CD8<sup>+</sup> T cells with enhanced cytolytic activity.|A|G|42|40.5|Non-synonymous|Unprocessed|APF-G1
1537723|IGL00691|2|58447573|D->G|||Benign|0.36|tolerated|MGI:87911|Acvr1|activin A receptor, type 1 [Source:MGI Symbol;Acc:MGI:87911]|Heterozygous||T|C|39|41.0|Non-synonymous|Unprocessed|APF-G1
1537724|IGL00691|5|52170093|Y->C||1.0|Probably damaging||deleterious|MGI:1099786|Dhx15|DEAH (Asp-Glu-Ala-His) box polypeptide 15 [Source:MGI Symbol;Acc:MGI:1099786]|Heterozygous||T|C|33|39.0|Non-synonymous|Unprocessed|APF-G1
1537725|IGL00691|10|81581739|D->G||0.46|Possibly damaging|0.05|tolerated|MGI:104635|Tle2|transducin-like enhancer of split 2, homolog of Drosophila E(spl) [Source:MGI Symbol;Acc:MGI:104635]|Heterozygous||A|G|26|38.0|Non-synonymous|Unprocessed|APF-G1
1537726|IGL00691|7|34245485|V->M||1.0|Probably damaging|0.11|tolerated|MGI:1924311|4931406p16rik|RIKEN cDNA 4931406P16 gene [Source:MGI Symbol;Acc:MGI:1924311]|Heterozygous||C|T|26|40.0|Non-synonymous|Unprocessed|APF-G1
1537727|IGL00691|8|76909590|S->F||0.36|Benign|0.15|tolerated|MGI:99459|Nr3c2|nuclear receptor subfamily 3, group C, member 2 [Source:MGI Symbol;Acc:MGI:99459]|Heterozygous|Mice homozygous for a targeted null mutation exhibit weight loss and symptoms of pseudohypoaldosteronism, and eventually die at around day 10 after birth from renal salt wasting and dehydration.|C|T|24|36.5|Non-synonymous|Unprocessed|APF-G1
1537728|IGL00691|X|112624811|R->Q||1.0|Probably damaging|0.11|tolerated|MGI:3045342|Zfp711|zinc finger protein 711 [Source:MGI Symbol;Acc:MGI:3045342]|Heterozygous||G|A|24|38.5|Non-synonymous|Unprocessed|APF-G1
1537729|IGL00691|9|106057407|G->C||1.0|Probably damaging||deleterious|MGI:1915803|Col6a4|collagen, type VI, alpha 4 [Source:MGI Symbol;Acc:MGI:1915803]|Heterozygous||C|A|22|37.5|Non-synonymous|Unprocessed|APF-G1
1537730|IGL00691|9|35053069|Disrupted splicing|||N/A|||MGI:1316743|St3gal4|ST3 beta-galactoside alpha-2,3-sialyltransferase 4 [Source:MGI Symbol;Acc:MGI:1316743]|Heterozygous|Mice homozygous for a knock-out allele display low platelet counts, altered platelet clearance by hepatocytes, prolonged bleeding times, and absence of L-selectin mediated leukocyte rolling.|A|G|32|39.0|Splice|Unprocessed|APF-G1
1537731|IGL00691|12|116138748|Disrupted splicing|||N/A|||MGI:107166|Vipr2|vasoactive intestinal peptide receptor 2 [Source:MGI Symbol;Acc:MGI:107166]|Heterozygous|Homozygotes for a targeted null mutation exhibit enhanced delayed-type hypersensitivity (type IV) and reduced immediate-type hypersensitivity (type I).|A|G|27|40.0|Splice|Unprocessed|APF-G1
1537732|IGL00691|2|157238307|Disrupted splicing|||N/A|||MGI:3603828|4922505g16rik|RIKEN cDNA 4922505G16 gene [Source:MGI Symbol;Acc:MGI:3603828]|Heterozygous||T|C|18|39.0|Splice|Unprocessed|APF-G1
1538706|IGL00693|13|106897260|F->Y||1.0|Probably damaging|0.01|deleterious|MGI:2442377|Ipo11|importin 11 [Source:MGI Symbol;Acc:MGI:2442377]|Heterozygous||A|T|154|39.0|Non-synonymous|Unprocessed|APF-G1
1538707|IGL00693|2|62734254|R->K|||Benign|0.59|tolerated|MGI:2159566|Kcnh7|potassium voltage-gated channel, subfamily H (eag-related), member 7 [Source:MGI Symbol;Acc:MGI:2159566]|Heterozygous||C|T|102|40.0|Non-synonymous|Unprocessed|APF-G1
1538708|IGL00693|4|143965822|P->Q||0.97|Probably damaging|0.16|tolerated|MGI:3650204|Gm13101|predicted gene 13101 [Source:MGI Symbol;Acc:MGI:3650204]|Heterozygous||G|T|61|41.0|Non-synonymous|Unprocessed|APF-G1
1538709|IGL00693|3|98806278|L->R||0.74|Possibly damaging|0.01|deleterious|MGI:109598|Hsd3b6|hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6 [Source:MGI Symbol;Acc:MGI:109598]|Heterozygous||A|C|60|40.0|Non-synonymous|Unprocessed|APF-G1
1538710|IGL00693|19|20700046|P->S||1.0|Probably damaging||deleterious|MGI:1347050|Aldh1a7|aldehyde dehydrogenase family 1, subfamily A7 [Source:MGI Symbol;Acc:MGI:1347050]|Heterozygous||G|A|44|41.0|Non-synonymous|Unprocessed|APF-G1
1538711|IGL00693|5|112422013|I->N||1.0|Probably damaging||deleterious|MGI:1935121|Sez6l|seizure related 6 homolog like [Source:MGI Symbol;Acc:MGI:1935121]|Heterozygous|Mice homozygous for a knock-out allele display slightly impaired coordination in the rotarod task.|A|T|43|40.0|Non-synonymous|Unprocessed|APF-G1
1538712|IGL00693|14|60238520|S->T|||Benign|0.14|tolerated|MGI:1919094|Nupl1|nucleoporin like 1 [Source:MGI Symbol;Acc:MGI:1919094]|Heterozygous||A|T|42|39.0|Non-synonymous|Unprocessed|APF-G1
1538713|IGL00693|17|46972981|T->A||0.04|Benign|0.86|tolerated|MGI:1861099|Ubr2|ubiquitin protein ligase E3 component n-recognin 2 [Source:MGI Symbol;Acc:MGI:1861099]|Heterozygous|On a mixed genetic background, female homozygotes for a targeted null mutation exhibit embryonic lethality, while males are viable, but sterile due to postnatal testicular degeneration. On an inbred background, both genders die in utero.|T|C|41|38.0|Non-synonymous|Unprocessed|APF-G1
1538714|IGL00693|9|73758602|D->E||1.0|Probably damaging|0.15|tolerated|MGI:2149021|Unc13c|unc-13 homolog C (C. elegans) [Source:MGI Symbol;Acc:MGI:2149021]|Heterozygous|Homozygous mutant mice demonstrate an impaired ability to learn complex motor tasks, putatively due to an observed increase in paired-pulse facilitation.|A|T|38|39.0|Non-synonymous|Unprocessed|APF-G1
1538715|IGL00693|1|131136337|I->V||0.01|Benign|0.4|tolerated|MGI:1330300|Dyrk3|dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 [Source:MGI Symbol;Acc:MGI:1330300]|Heterozygous|Mice homozygous for a null allele exhibit increased erythropoiesis in response to chemically-induced anemia.|T|C|36|39.0|Non-synonymous|Unprocessed|APF-G1
1538716|IGL00693|1|172561589|V->A||0.94|Possibly damaging|0.72|tolerated|MGI:3642995|Vsig8|V-set and immunoglobulin domain containing 8 [Source:MGI Symbol;Acc:MGI:3642995]|Heterozygous||T|C|33|40.0|Non-synonymous|Unprocessed|APF-G1
1538717|IGL00693|2|30255315|V->A||0.94|Possibly damaging|0.01|deleterious|MGI:2652847|Lrrc8a|leucine rich repeat containing 8A [Source:MGI Symbol;Acc:MGI:2652847]|Heterozygous||T|C|29|38.0|Non-synonymous|Unprocessed|APF-G1
1538718|IGL00693|11|40754058|V->A|||Benign|0.63|tolerated|MGI:102890|Ccng1|cyclin G1 [Source:MGI Symbol;Acc:MGI:102890]|Heterozygous|Depending on the allele, homozygous mutants exhibit increased cellular sensitivity to gamma-irradiation or decreased incidence of induced hepatic tumors.|A|G|26|39.0|Non-synonymous|Unprocessed|APF-G1
1538719|IGL00693|17|34591273|E->G||1.0|Probably damaging|0.01|deleterious|MGI:2146785|Gpsm3|G-protein signalling modulator 3 (AGS3-like, C. elegans) [Source:MGI Symbol;Acc:MGI:2146785]|Heterozygous||A|G|25|39.0|Non-synonymous|Unprocessed|APF-G1
1538720|IGL00693|2|180032626|N->D||1.0|Probably damaging|0.01|deleterious|MGI:3040677|Lsm14b|LSM14 homolog B (SCD6, S. cerevisiae) [Source:MGI Symbol;Acc:MGI:3040677]|Heterozygous||A|G|23|40.0|Non-synonymous|Unprocessed|APF-G1
1538721|IGL00693|1|82697754|Y->H|||Unknown|0.55|tolerated|MGI:104688|Col4a3|collagen, type IV, alpha 3 [Source:MGI Symbol;Acc:MGI:104688]|Heterozygous|Homozygotes for targeted null mutations exhibit renal pathology including reduced glomerular filtration, impaired glomerular integrity, and glomerulonephrosis, resulting in uremia, proteinuria, and high mortality in young adults.  Auditory thresholds are mildly increased across all test frequencies.|T|C|22|35.0|Non-synonymous|Unprocessed|APF-G1
1538722|IGL00693|15|58944124|D->V||1.0|Probably damaging||deleterious|MGI:2384818|Mtss1|metastasis suppressor 1 [Source:MGI Symbol;Acc:MGI:2384818]|Heterozygous|Mice homozygous for a gene trap allele exhibit polycystic kidney in 50% of mice by 5 months of age. Mouse embryonic fibroblasts from mice homozygous for a different gene trap allele exhibit altered cell morphology and physiology.|T|A|22|39.0|Non-synonymous|Unprocessed|APF-G1
1538723|IGL00693|16|69860518|M->K|||Benign|0.01|deleterious|MGI:2668488|Speer2|spermatogenesis associated glutamate (E)-rich protein 2 [Source:MGI Symbol;Acc:MGI:2668488]|Heterozygous||A|T|22|39.0|Non-synonymous|Unprocessed|APF-G1
1538724|IGL00693|18|32123513|V->A||0.02|Benign|0.42|tolerated|MGI:97771|Proc|protein C [Source:MGI Symbol;Acc:MGI:97771]|Heterozygous|Inactivation of the locus results in death within 24 hours of birth due to consumptive coagulopathy. Thromboses and bleeding are observed in the brains and livers of homozygous mutant mice.|A|G|21|38.0|Non-synonymous|Unprocessed|APF-G1
1538725|IGL00693|15|81815183|S->P|||Benign|0.25|tolerated|MGI:98663|Tef|thyrotroph embryonic factor [Source:MGI Symbol;Acc:MGI:98663]|Heterozygous|Homozygous mutant are subject to seizures.|T|C|20|35.5|Non-synonymous|Unprocessed|APF-G1
1538726|IGL00693|11|17211317|L->P|||Benign|0.28|tolerated|MGI:1913499|Pno1|partner of NOB1 homolog (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1913499]|Heterozygous||A|G|19|34.0|Non-synonymous|Unprocessed|APF-G1
1538727|IGL00693|18|7211504|G->D||1.0|Probably damaging|0.08|tolerated|MGI:1922184|Armc4|armadillo repeat containing 4 [Source:MGI Symbol;Acc:MGI:1922184]|Heterozygous||C|T|18|39.0|Non-synonymous|Unprocessed|APF-G1
1538728|IGL00693|7|110134853|Disrupted splicing|||N/A|||MGI:103075|Wee1|WEE 1 homolog 1 (S. pombe) [Source:MGI Symbol;Acc:MGI:103075]|Heterozygous||A|T|147|39.0|Splice|Unprocessed|APF-G1
1538729|IGL00693|3|37052547|Disrupted splicing|||N/A|||MGI:2444631|4932438a13rik|RIKEN cDNA 4932438A13 gene [Source:MGI Symbol;Acc:MGI:2444631]|Heterozygous||A|G|28|39.0|Splice|Unprocessed|APF-G1
1539243|IGL00694|14|52217970|V->G||1.0|Probably damaging||deleterious|MGI:1915022|Chd8|chromodomain helicase DNA binding protein 8 [Source:MGI Symbol;Acc:MGI:1915022]|Heterozygous|Homozygous null embryos are growth retarded starting at E5.5 and exhibit developmental arrest at E6.5.  Mutants develop into an egg cylinder but do not form a primitive streak or mesoderm and exhibit increased apoptosis at E7.5.|A|C|197|38.0|Non-synonymous|Unprocessed|APF-G1
1539244|IGL00694|2|23230168|Q->L||0.16|Benign||deleterious|MGI:1918231|4931423n10rik|RIKEN cDNA 4931423N10 gene [Source:MGI Symbol;Acc:MGI:1918231]|Heterozygous||A|T|143|40.0|Non-synonymous|Unprocessed|APF-G1
1539245|IGL00694|6|24570664|R->L||0.99|Probably damaging|0.13|tolerated|MGI:1926160|Asb15|ankyrin repeat and SOCS box-containing 15 [Source:MGI Symbol;Acc:MGI:1926160]|Heterozygous||G|T|136|39.0|Non-synonymous|Unprocessed|APF-G1
1539246|IGL00694|19|39321635|T->S|||Benign|0.08|tolerated|MGI:103238|Cyp2c29|cytochrome P450, family 2, subfamily c, polypeptide 29 [Source:MGI Symbol;Acc:MGI:103238]|Heterozygous||A|T|116|39.0|Non-synonymous|Unprocessed|APF-G1
1539247|IGL00694|6|94534223|I->N||0.94|Possibly damaging|0.11|tolerated|MGI:1914832|Slc25a26|solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 26 [Source:MGI Symbol;Acc:MGI:1914832]|Heterozygous|Embryos homozygous for a transposon insertion appear growth retarded and underdeveloped and die after E8.5 but prior to birth.|T|A|78|39.0|Non-synonymous|Unprocessed|APF-G1
1539248|IGL00694|8|110969581|H->L||0.97|Probably damaging|0.11|tolerated|MGI:99427|St3gal2|ST3 beta-galactoside alpha-2,3-sialyltransferase 2 [Source:MGI Symbol;Acc:MGI:99427]|Heterozygous|Mice homozygous for disruptions in this gene apparently display a normal phenotype.|A|T|74|39.0|Non-synonymous|Unprocessed|APF-G1
1539249|IGL00694|4|143965822|P->Q||0.97|Probably damaging|0.16|tolerated|MGI:3650204|Gm13101|predicted gene 13101 [Source:MGI Symbol;Acc:MGI:3650204]|Heterozygous||G|T|71|41.0|Non-synonymous|Unprocessed|APF-G1
1539250|IGL00694|5|100655314|S->N|||Benign|0.34|tolerated|MGI:1919133|Coq2|coenzyme Q2 homolog, prenyltransferase (yeast) [Source:MGI Symbol;Acc:MGI:1919133]|Heterozygous||C|T|62|40.0|Non-synonymous|Unprocessed|APF-G1
1539251|IGL00694|6|132657275|F->L|||Benign|1.0|tolerated|MGI:2681256|Tas2r120|taste receptor, type 2, member 120 [Source:MGI Symbol;Acc:MGI:2681256]|Heterozygous||T|C|51|39.0|Non-synonymous|Unprocessed|APF-G1
1539252|IGL00694|9|53563517|T->A|||Benign|1.0|tolerated|MGI:107605|Npat|nuclear protein in the AT region [Source:MGI Symbol;Acc:MGI:107605]|Heterozygous||A|G|45|40.0|Non-synonymous|Unprocessed|APF-G1
1539253|IGL00694|18|9989744|D->G||1.0|Probably damaging|0.01|deleterious|MGI:1919668|Thoc1|THO complex 1 [Source:MGI Symbol;Acc:MGI:1919668]|Heterozygous|Mutations in this gene result in embryonic lethality around implantation in homozygotes.|A|G|44|40.0|Non-synonymous|Unprocessed|APF-G1
1539254|IGL00694|6|142790289|I->T||0.79|Possibly damaging||deleterious|MGI:2685612|Gm766|predicted gene 766 [Source:MGI Symbol;Acc:MGI:2685612]|Heterozygous||A|G|43|40.0|Non-synonymous|Unprocessed|APF-G1
1539255|IGL00694|6|134849195|S->R||1.0|Probably damaging||deleterious|MGI:1889385|Crebl2|cAMP responsive element binding protein-like 2 [Source:MGI Symbol;Acc:MGI:1889385]|Heterozygous||T|A|42|38.0|Non-synonymous|Unprocessed|APF-G1
1539256|IGL00694|2|114151525|D->E||1.0|Probably damaging|0.01|deleterious|MGI:1276102|Aqr|aquarius [Source:MGI Symbol;Acc:MGI:1276102]|Heterozygous|Homozygotes for a targeted null mutation exhibit severe defects in placental vascularization with few vessels entering the placenta and little branching. Mutants die between embryonic days 9.5 and 10.5.|A|T|41|39.0|Non-synonymous|Unprocessed|APF-G1
1539257|IGL00694|15|57821760|N->S|||Benign|0.79|tolerated|MGI:2683087|Zhx2|zinc fingers and homeoboxes 2 [Source:MGI Symbol;Acc:MGI:2683087]|Heterozygous||A|G|38|36.5|Non-synonymous|Unprocessed|APF-G1
1539258|IGL00694|2|106967192|F->L||0.94|Possibly damaging|0.02|deleterious|MGI:1926020|2700007p21rik|RIKEN cDNA 2700007P21 gene [Source:MGI Symbol;Acc:MGI:1926020]|Heterozygous||A|T|38|40.0|Non-synonymous|Unprocessed|APF-G1
1539259|IGL00694|7|81306708|V->A||0.19|Benign|0.51|tolerated|MGI:1277116|Pde8a|phosphodiesterase 8A [Source:MGI Symbol;Acc:MGI:1277116]|Heterozygous|Targeted disruption of this gene results in a 4-fold increase in basal release of testosterone in isolated Leydig cells as well as a significant increase in the sensitivity to luteinizing hormone, measured as testosterone released into the media.|T|C|38|40.0|Non-synonymous|Unprocessed|APF-G1
1539260|IGL00694|2|34991629|I->V|||Benign|1.0|tolerated|MGI:96031|Hc|hemolytic complement [Source:MGI Symbol;Acc:MGI:96031]|Heterozygous|Macrophage from mice homozygous for disruptions of this gene do not secrete complement C5. The 2 bp deletion found in A/J and AKR/J strains is associated with susceptibility to allergen-induced bronchial hyperresponsiveness and is a candidate for QTL Abhr2.|T|C|33|38.0|Non-synonymous|Unprocessed|APF-G1
1539261|IGL00694|18|58037809|E->A||0.59|Possibly damaging|0.4|tolerated|MGI:95490|Fbn2|fibrillin 2 [Source:MGI Symbol;Acc:MGI:95490]|Heterozygous|Homozygotes for spontaneous, chemically-induced, and targeted null mutations show bilateral syndactyly with fusion of both soft and hard tissues. Deafness found in an X-ray induced allelic mutant is apparently due to the joint disruption of a linked gene.|T|G|29|39.0|Non-synonymous|Unprocessed|APF-G1
1539262|IGL00694|5|25293161|F->I||1.0|Probably damaging|0.01|deleterious|MGI:2444959|Mll3|myeloid/lymphoid or mixed-lineage leukemia 3 [Source:MGI Symbol;Acc:MGI:2444959]|Heterozygous|Mice homozygous for a knock-out allele display partial embryonic lethality, delayed eyelid opening, postnatal growth retardation, impaired fertility in both sexes, and decreased proliferation of cultured mouse embryonic fibroblasts.|A|T|29|36.0|Non-synonymous|Unprocessed|APF-G1
1539263|IGL00694|15|36227171|E->V||0.97|Probably damaging|0.01|deleterious|MGI:1349387|Spag1|sperm associated antigen 1 [Source:MGI Symbol;Acc:MGI:1349387]|Heterozygous||A|T|26|38.5|Non-synonymous|Unprocessed|APF-G1
1539264|IGL00694|6|108841601|I->T||0.97|Probably damaging||deleterious|MGI:2180139|Edem1|ER degradation enhancer, mannosidase alpha-like 1 [Source:MGI Symbol;Acc:MGI:2180139]|Heterozygous||T|C|24|39.5|Non-synonymous|Unprocessed|APF-G1
1539265|IGL00694|5|108613634|E->A||1.0|Probably damaging||deleterious|MGI:2442153|Gak|cyclin G associated kinase [Source:MGI Symbol;Acc:MGI:2442153]|Heterozygous||T|G|23|40.0|Non-synonymous|Unprocessed|APF-G1
1539266|IGL00694|12|30105994|R->S||0.98|Probably damaging|0.04|deleterious|MGI:98813|Tpo|thyroid peroxidase [Source:MGI Symbol;Acc:MGI:98813]|Heterozygous|Homozygous mice with a missense mutation exhibit hypothyroid dwarfism, including a goiter with colloid deficiency and abnormal follicle epithelium, reduced hematocrit and red blood cells and a lifespan of about 3 months.|T|A|22|37.5|Non-synonymous|Unprocessed|APF-G1
1539267|IGL00694|8|35590771|R->Q||1.0|Probably damaging|0.28|tolerated|MGI:1098644|Mfhas1|malignant fibrous histiocytoma amplified sequence 1 [Source:MGI Symbol;Acc:MGI:1098644]|Heterozygous||G|A|16|41.0|Non-synonymous|Unprocessed|APF-G1
1539268|IGL00694|3|151439396|Disrupted splicing|||N/A|||MGI:2655562|Eltd1|EGF, latrophilin seven transmembrane domain containing 1 [Source:MGI Symbol;Acc:MGI:2655562]|Heterozygous||T|C|48|38.0|Splice|Unprocessed|APF-G1
1539779|IGL00695|3|138221734|V->I||0.15|Benign|0.27|tolerated|MGI:87926|Adh7|alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide [Source:MGI Symbol;Acc:MGI:87926]|Heterozygous|Homozygous mutation of this gene results in defective ethanol clearance and reduced metabolism of retinal to retinoic acid.|G|A|30|39.0|Non-synonymous|Unprocessed|APF-G1
1539780|IGL00695|1|160993400|F->S||1.0|Probably damaging||deleterious|MGI:88095|Serpinc1|serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1 [Source:MGI Symbol;Acc:MGI:88095]|Heterozygous|Homozygotes for a targeted null mutation exhibit extensive subcutaneous hemorrhage, fibrin deposits in the myocardium and liver, and lethality by embryonic day 16.5. Heterozygotes challenged with lipopolysaccharide show increased fibrin deposits.|T|C|20|40.0|Non-synonymous|Unprocessed|APF-G1
1539781|IGL00695|8|26059250|T->A||0.69|Possibly damaging|0.19|tolerated|MGI:2443554|Hook3|hook homolog 3 (Drosophila) [Source:MGI Symbol;Acc:MGI:2443554]|Heterozygous||T|C|17|40.0|Non-synonymous|Unprocessed|APF-G1
1539782|IGL00695|16|35814061|Disrupted splicing|||N/A|||MGI:1913917|Hspbap1|Hspb associated protein 1 [Source:MGI Symbol;Acc:MGI:1913917]|Heterozygous||C|A|23|39.0|Splice|Unprocessed|APF-G1
1539783|IGL00695|13|74206906|Disrupted splicing|||N/A|||MGI:2443972|Exoc3|exocyst complex component 3 [Source:MGI Symbol;Acc:MGI:2443972]|Heterozygous||C|T|18|38.0|Splice|Unprocessed|APF-G1
1540234|IGL00696|6|7866475|V->A||0.99|Probably damaging||deleterious|MGI:2151071|C1galt1|core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1 [Source:MGI Symbol;Acc:MGI:2151071]|Heterozygous|Embryos homozygous for a null allele show impaired angiogenesis, chaotic microvascular networks in brain, and fatal hemorrhage by E14. Eggs homozygous for another null allele show a slightly thinner zona pellucida. Mice homozygous for an ENU-induced allele develop thrombocytopenia and renal disease.|T|C|81|40.0|Non-synonymous|Unprocessed|APF-G1
1540235|IGL00696|16|16342715|S->P|||N/A|0.28|tolerated|MGI:1921256|Dnm1l|dynamin 1-like [Source:MGI Symbol;Acc:MGI:1921256]|Heterozygous|Mice homozygous for a knock-out allele exhibit embryonic lethality at E11.5 with internal hemorrhage and small size. Mice heterozygous for an ENU induced allele have dilated cardiomyopathy and congestive heart failure, homozygous are embryonic lethal with posterior truncation at E11.5.|A|G|79|40.0|Non-synonymous|Unprocessed|APF-G1
1540236|IGL00696|X|155053436|F->S||0.68|Possibly damaging||deleterious|MGI:1333838|Magea5|melanoma antigen, family A, 5 [Source:MGI Symbol;Acc:MGI:1333838]|Heterozygous||A|G|59|41.0|Non-synonymous|Unprocessed|APF-G1
1540237|IGL00696|18|43767029|F->L|||Unknown|||MGI:2153470|Scgb3a2|secretoglobin, family 3A, member 2 [Source:MGI Symbol;Acc:MGI:2153470]|Heterozygous||T|A|34|41.0|Non-synonymous|Unprocessed|APF-G1
1540238|IGL00696|7|25342392|I->V|||Benign|0.37|tolerated|MGI:2446294|Megf8|multiple EGF-like-domains 8 [Source:MGI Symbol;Acc:MGI:2446294]|Heterozygous||A|G|33|40.0|Non-synonymous|Unprocessed|APF-G1
1540239|IGL00696|1|120171426|E->G||0.98|Probably damaging|0.02|deleterious|MGI:1920353|3110009e18rik|RIKEN cDNA 3110009E18 gene [Source:MGI Symbol;Acc:MGI:1920353]|Heterozygous||A|G|30|40.0|Non-synonymous|Unprocessed|APF-G1
1540240|IGL00696|4|124742535|M->R||0.92|Possibly damaging||deleterious|MGI:103257|Inpp5b|inositol polyphosphate-5-phosphatase B [Source:MGI Symbol;Acc:MGI:103257]|Heterozygous|Homozygous null male mice are infertile with a disruption in spermatogenesis and a defect in adherens junctions processing.|T|G|27|40.0|Non-synonymous|Unprocessed|APF-G1
1540241|IGL00696|15|99210894|K->R||0.34|Benign|0.21|tolerated|MGI:1919822|Spats2|spermatogenesis associated, serine-rich 2 [Source:MGI Symbol;Acc:MGI:1919822]|Heterozygous||A|G|25|40.0|Non-synonymous|Unprocessed|APF-G1
1540242|IGL00696|12|57542657|Y->C||1.0|Probably damaging||deleterious|MGI:1347472|Foxa1|forkhead box A1 [Source:MGI Symbol;Acc:MGI:1347472]|Heterozygous|Homozygotes for targeted null mutations exhibit abnormal feeding, hypoglycemia, impaired glucagon secretion, hypotryglyceridemia, wasting, and lethality between postnatal days 2 and 14.|T|C|23|33.0|Non-synonymous|Unprocessed|APF-G1
1540243|IGL00696|7|82651872|Disrupted splicing|||N/A|||MGI:2141969|Eftud1|elongation factor Tu GTP binding domain containing 1 [Source:MGI Symbol;Acc:MGI:2141969]|Heterozygous||G|A|52|40.0|Splice|Unprocessed|APF-G1
1540244|IGL00696|11|65841238|Disrupted splicing|||N/A|||MGI:1289279|Dnahc9|dynein, axonemal, heavy chain 9 [Source:MGI Symbol;Acc:MGI:1289279]|Heterozygous||T|C|24|39.0|Splice|Unprocessed|APF-G1
1540727|IGL00697|2|164289812|E->V||0.82|Possibly damaging|||MGI:1927635|Svs3a|seminal vesicle secretory protein 3A [Source:MGI Symbol;Acc:MGI:1927635]|Heterozygous|At this locus, the a allele determines a slow anodally migrating enzyme band and occurs in the B10.AKM/Sn strain; the b allele determines a faster band and occurs in AKR.M/Sn, C3H/He and C57BL/10Orl strains. Heterozygotes have the two parental bands.|A|T|52|37.0|Non-synonymous|Unprocessed|APF-G1
1540728|IGL00697|3|108775008|D->E|||Unknown|1.0|tolerated|MGI:3584453|Aknad1|AKNA domain containing 1 [Source:MGI Symbol;Acc:MGI:3584453]|Heterozygous||T|A|47|40.0|Non-synonymous|Unprocessed|APF-G1
1540729|IGL00697|X|152339714|D->G||1.0|Probably damaging|0.01|deleterious|MGI:106244|Tspyl2|TSPY-like 2 [Source:MGI Symbol;Acc:MGI:106244]|Heterozygous||T|C|41|38.0|Non-synonymous|Unprocessed|APF-G1
1540730|IGL00697|13|65066701|S->N|||Benign|0.36|tolerated|MGI:1913881|Hiatl1|hippocampus abundant transcript-like 1 [Source:MGI Symbol;Acc:MGI:1913881]|Heterozygous||C|T|36|40.0|Non-synonymous|Unprocessed|APF-G1
1540731|IGL00697|15|12373647|Y->C||0.16|Benign|0.08|tolerated|MGI:1922394|Pdzd2|PDZ domain containing 2 [Source:MGI Symbol;Acc:MGI:1922394]|Heterozygous|Mice homozygous for a gene trapped allele exhibit normal response to acute and chronic pain.|T|C|36|35.0|Non-synonymous|Unprocessed|APF-G1
1540732|IGL00697|5|23540379|R->Q||0.22|Benign|0.25|tolerated|MGI:1201408|Srpk2|serine/arginine-rich protein specific kinase 2 [Source:MGI Symbol;Acc:MGI:1201408]|Heterozygous|Mice homozygous for a targeted allele exhibit normal phenotype.|C|T|29|39.0|Non-synonymous|Unprocessed|APF-G1
1540733|IGL00697|7|125795450|V->M||0.92|Possibly damaging|0.11|tolerated|MGI:2442760|D430042o09rik|RIKEN cDNA D430042O09 gene [Source:MGI Symbol;Acc:MGI:2442760]|Heterozygous||G|A|28|40.0|Non-synonymous|Unprocessed|APF-G1
1540734|IGL00697|6|113314986|L->Q||1.0|Probably damaging||deleterious|MGI:1926033|Brpf1|bromodomain and PHD finger containing, 1 [Source:MGI Symbol;Acc:MGI:1926033]|Heterozygous||T|A|24|38.5|Non-synonymous|Unprocessed|APF-G1
1540735|IGL00697|13|49709728|F->Y||1.0|Probably damaging|0.01|deleterious|MGI:2145219|Iars|isoleucine-tRNA synthetase [Source:MGI Symbol;Acc:MGI:2145219]|Heterozygous||T|A|16|38.0|Non-synonymous|Unprocessed|APF-G1
1540736|IGL00697|4|6417163|Disrupted splicing|||N/A|||MGI:1341864|Nsmaf|neutral sphingomyelinase (N-SMase) activation associated factor [Source:MGI Symbol;Acc:MGI:1341864]|Heterozygous|Mice homozygous for a targeted null mutation show no gross phenotypic abnormalities but display delayed cutaneous barrier repair.  In addition, D-galactosamine-sensitized homozygotes are partially resistant to LPS- and TNF-induced lethality.|A|G|163|37.0|Splice|Unprocessed|APF-G1
1540737|IGL00697|18|20524689|Disrupted splicing|||N/A|||MGI:99499|Dsg3|desmoglein 3 [Source:MGI Symbol;Acc:MGI:99499]|Heterozygous|Homozygous mutants display runting from decreased food intake due to oropharyngeal epithelial lesions, blisters around snout and eyes, hair loss by weaning, and hair regrowth with bald patches throughout life.|T|C|67|40.0|Splice|Unprocessed|APF-G1
1540738|IGL00697|X|130460940|Disrupted splicing|||N/A|||MGI:1858500|Diap2|diaphanous homolog 2 (Drosophila) [Source:MGI Symbol;Acc:MGI:1858500]|Heterozygous||C|T|48|37.5|Splice|Unprocessed|APF-G1
1540739|IGL00697|1|55061265|Disrupted splicing|||N/A|||MGI:1915126|Coq10b|coenzyme Q10 homolog B (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1915126]|Heterozygous||T|A|20|39.0|Splice|Unprocessed|APF-G1
1541226|IGL00698|X|96338481|I->T||0.94|Possibly damaging|0.1|tolerated|MGI:3045337|Hsf3|heat shock transcription factor 3 [Source:MGI Symbol;Acc:MGI:3045337]|Heterozygous||A|G|67|37.0|Non-synonymous|Unprocessed|APF-G1
1541227|IGL00698|10|105793340|C->F||0.78|Possibly damaging|0.02|deleterious|MGI:3041259|Bc067068|cDNA sequence BC067068 [Source:MGI Symbol;Acc:MGI:3041259]|Heterozygous||C|A|56|41.0|Non-synonymous|Unprocessed|APF-G1
1541228|IGL00698|11|33441910|T->A|||Benign|0.46|tolerated|MGI:1929706|Ranbp17|RAN binding protein 17 [Source:MGI Symbol;Acc:MGI:1929706]|Heterozygous||T|C|56|38.5|Non-synonymous|Unprocessed|APF-G1
1541229|IGL00698|10|115419832|F->L||0.98|Probably damaging|||MGI:2446143|Zfc3h1|zinc finger, C3H1-type containing [Source:MGI Symbol;Acc:MGI:2446143]|Heterozygous||T|C|29|38.0|Non-synonymous|Unprocessed|APF-G1
1541230|IGL00698|11|69349871|S->P||0.99|Probably damaging|0.08|tolerated|MGI:1344395|Chd3|chromodomain helicase DNA binding protein 3 [Source:MGI Symbol;Acc:MGI:1344395]|Heterozygous||A|G|28|39.0|Non-synonymous|Unprocessed|APF-G1
1541231|IGL00698|11|12253722|N->K||0.16|Benign|0.33|tolerated|MGI:105056|Cobl|cordon-bleu [Source:MGI Symbol;Acc:MGI:105056]|Heterozygous|Animals homozygous for this mutation do not display a phenotype.  However, the allele exacerbates the neural tube defects seen in the loop tail mouse.|G|T|26|40.0|Non-synonymous|Unprocessed|APF-G1
1541232|IGL00698|11|76840444|E->G||0.93|Possibly damaging|0.35|tolerated|MGI:107265|Cpd|carboxypeptidase D [Source:MGI Symbol;Acc:MGI:107265]|Heterozygous||T|C|21|39.0|Non-synonymous|Unprocessed|APF-G1
1541233|IGL00698|17|55897565|T->A||0.79|Possibly damaging|0.01|deleterious|MGI:2385058|Zfp959|zinc finger protein 959 [Source:MGI Symbol;Acc:MGI:2385058]|Heterozygous||A|G|21|36.0|Non-synonymous|Unprocessed|APF-G1
1541234|IGL00698|3|38981145|P->Q|||Benign|0.19|tolerated|MGI:3045256|Fat4|FAT tumor suppressor homolog 4 (Drosophila) [Source:MGI Symbol;Acc:MGI:3045256]|Heterozygous||C|A|21|37.0|Non-synonymous|Unprocessed|APF-G1
1541235|IGL00698|6|65952895|V->E||1.0|Probably damaging||deleterious|MGI:1914903|4930544g11rik|RIKEN cDNA 4930544G11 gene [Source:MGI Symbol;Acc:MGI:1914903]|Heterozygous||T|A|21|38.0|Non-synonymous|Unprocessed|APF-G1
1541236|IGL00698|3|37320794|S->P|||Benign|0.26|tolerated|MGI:2686651|Bbs12|Bardet-Biedl syndrome 12 (human) [Source:MGI Symbol;Acc:MGI:2686651]|Heterozygous||T|C|16|38.5|Non-synonymous|Unprocessed|APF-G1
1541700|IGL00699|X|7617209|D->E||1.0|Probably damaging||deleterious|MGI:1859639|Cacna1f|calcium channel, voltage-dependent, alpha 1F subunit [Source:MGI Symbol;Acc:MGI:1859639]|Heterozygous|Homozygous or hemizygous mutation of this gene results in impaired eye electrophysiology, abnormal retinal neuronal layer, bipolar cell, and horizontal cell morphology, and impaired retinal synapse morphology.|T|A|62|37.0|Non-synonymous|Unprocessed|APF-G1
1541701|IGL00699|12|65053341|F->L||0.02|Benign|0.23|tolerated|MGI:104602|Prpf39|PRP39 pre-mRNA processing factor 39 homolog (yeast) [Source:MGI Symbol;Acc:MGI:104602]|Heterozygous||T|C|55|40.0|Non-synonymous|Unprocessed|APF-G1
1541702|IGL00699|10|18853632|M->V|||Benign|0.8|tolerated|MGI:1929938|Perp|PERP, TP53 apoptosis effector [Source:MGI Symbol;Acc:MGI:1929938]|Heterozygous|Homozygous inactivation of this locus results in increased lethality during the postnatal period.|A|G|37|40.0|Non-synonymous|Unprocessed|APF-G1
1541703|IGL00699|12|112852649|E->K||1.0|Probably damaging||deleterious|MGI:1890220|Gpr132|G protein-coupled receptor 132 [Source:MGI Symbol;Acc:MGI:1890220]|Heterozygous|Mice homozygous for disruptions in this gene display a generally normal phenotype but eventually develop a late onset lymphoproliferative autoimmune syndrome|C|T|34|39.5|Non-synonymous|Unprocessed|APF-G1
1541704|IGL00699|5|124387551|Y->H||1.0|Probably damaging||deleterious|MGI:2384298|Sbno1|sno, strawberry notch homolog 1 (Drosophila) [Source:MGI Symbol;Acc:MGI:2384298]|Heterozygous||A|G|27|37.0|Non-synonymous|Unprocessed|APF-G1
1541705|IGL00699|18|32097234|A->S|||Benign|0.68|tolerated|MGI:1920723|Iws1|IWS1 homolog (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1920723]|Heterozygous||G|T|22|40.0|Non-synonymous|Unprocessed|APF-G1
1541706|IGL00699|19|8678275|N->D||1.0|Probably damaging|0.01|deleterious|MGI:88396|Chrm1|cholinergic receptor, muscarinic 1, CNS [Source:MGI Symbol;Acc:MGI:88396]|Heterozygous|Homozygotes for targeted null mutations exhibit resistance to pilocarpine-induced seizures, selective memory deficits, elevated dopaminergic transmission in the striatum, and increased spontaneous and amphetamine-induced locomotion.|A|G|22|41.0|Non-synonymous|Unprocessed|APF-G1
1541707|IGL00699|4|126165578|G->S|||Benign|1.0|tolerated|MGI:2442637|Thrap3|thyroid hormone receptor associated protein 3 [Source:MGI Symbol;Acc:MGI:2442637]|Heterozygous||C|T|22|39.0|Non-synonymous|Unprocessed|APF-G1
1541708|IGL00699|7|3658080|T->M||0.97|Probably damaging|0.1|tolerated|MGI:2385261|Cnot3|CCR4-NOT transcription complex, subunit 3 [Source:MGI Symbol;Acc:MGI:2385261]|Heterozygous||C|T|21|40.0|Non-synonymous|Unprocessed|APF-G1
1541709|IGL00699|7|57765571|F->I||1.0|Probably damaging||deleterious|MGI:95621|Gabrb3|gamma-aminobutyric acid (GABA) A receptor, subunit beta 3 [Source:MGI Symbol;Acc:MGI:95621]|Heterozygous|Homozygous null mutants die at birth with cleft palate. Survivors show delayed growth, reduced lifespan, seizures, ataxia, hyperactivity, hyperresponsiveness and reduced learning, mothering ability and REM sleep. A point mutation lowers anesthetic effect.|T|A|21|39.0|Non-synonymous|Unprocessed|APF-G1
1541710|IGL00699|2|14102466|V->I|||Benign|0.27|tolerated|MGI:1329014|Stam|signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 [Source:MGI Symbol;Acc:MGI:1329014]|Heterozygous|Mice homozygous for a targeted null mutation exhibit progressive growth retardation, priapism, male infertility, degeneration of hippocapal CA3 pyramidal neurons and premature death, but exhibit normal lymphocyte development, proliferation and responses.|G|A|20|40.0|Non-synonymous|Unprocessed|APF-G1
1541711|IGL00699|9|98992165|G->R||1.0|Probably damaging|0.15|tolerated|MGI:1344387|Faim|Fas apoptotic inhibitory molecule [Source:MGI Symbol;Acc:MGI:1344387]|Heterozygous|Mice homozygous for a null allele have thymocytes with an enhanced susceptibility to FAS-induced apoptosis, and B cells that more susceptible to activation induced cell death.|G|A|20|39.0|Non-synonymous|Unprocessed|APF-G1
1541712|IGL00699|10|127526703|F->L||0.67|Possibly damaging|0.04|deleterious|MGI:1336197|Nxph4|neurexophilin 4 [Source:MGI Symbol;Acc:MGI:1336197]|Heterozygous||G|T|16|39.0|Non-synonymous|Unprocessed|APF-G1
1541713|IGL00699|5|21947427|V->A|||N/A|0.1|tolerated|MGI:103022|Reln|reelin [Source:MGI Symbol;Acc:MGI:103022]|Heterozygous|Homozygotes for most spontaneous or ENU-induced mutations show impaired righting responses, ataxia, tremors, and cerebellum and hippocampus abnormalities. Some mutants show postnatal or premature death and decreased body size while others have abnormal retinas or olfactory bulbs or infertility.|A|G|16|39.5|Non-synonymous|Unprocessed|APF-G1
1541714|IGL00699|1|180650732|Disrupted splicing|||N/A|||MGI:1919818|Lin9|lin-9 homolog (C. elegans) [Source:MGI Symbol;Acc:MGI:1919818]|Heterozygous|Mice homozygous for a gene trap allele die after implantation and exhibit abnormal embrygenesis. Mice homozygous for a conditional knock-out ubiquitously activated in adults die prematurely and exhibit small intestine epithelium atrophy and abnormal mitosis.|T|A|138|41.0|Splice|Unprocessed|APF-G1
1541715|IGL00699|3|105665547|Disrupted splicing|||N/A|||MGI:1928743|Kcnd3|potassium voltage-gated channel, Shal-related family, member 3 [Source:MGI Symbol;Acc:MGI:1928743]|Heterozygous|Mice homozygous for a reporter (null) allele are viable and fertile and exhibit normal cardiac morphology and function.|G|A|26|36.5|Splice|Unprocessed|APF-G1
1541716|IGL00699|2|65520821|Disrupted splicing|||N/A|||MGI:98249|Scn3a|sodium channel, voltage-gated, type III, alpha [Source:MGI Symbol;Acc:MGI:98249]|Heterozygous|Homozygous mutation of this gene results in lethality of most mutants by weaning. Heterozygous mice exhibit improved glucose tolerance.|A|G|23|40.0|Splice|Unprocessed|APF-G1
1542236|IGL00700|19|40180453|V->A||0.01|Benign|0.02|deleterious|MGI:2385878|Cyp2c70|cytochrome P450, family 2, subfamily c, polypeptide 70 [Source:MGI Symbol;Acc:MGI:2385878]|Heterozygous||A|G|44|37.0|Non-synonymous|Unprocessed|APF-G1
1542237|IGL00700|X|113116257|T->M||0.02|Benign|0.17|tolerated|MGI:892979|Chm|choroidermia [Source:MGI Symbol;Acc:MGI:892979]|Heterozygous|For one disruption of this gene, heterozygous female and hemizygous male null mice display embryonic lethality with abnormal extraembryonic tissue development.  For other disruptions however, heterozygous mice do survive and display depigmentation and degeneration of the retina.|G|A|44|40.0|Non-synonymous|Unprocessed|APF-G1
1542238|IGL00700|14|103139453|I->M|||Benign|0.38|tolerated|MGI:2179432|Mycbp2|MYC binding protein 2 [Source:MGI Symbol;Acc:MGI:2179432]|Heterozygous|Mice homozygous for a targeted allele exhibit neonatal lethality, defective diaphragm innervation, abnormal brain morphology and defective axonal guidance.|A|C|34|40.0|Non-synonymous|Unprocessed|APF-G1
1542239|IGL00700|15|9676489|N->K||0.83|Possibly damaging|0.08|tolerated|MGI:2443727|Spef2|sperm flagellar 2 [Source:MGI Symbol;Acc:MGI:2443727]|Heterozygous||A|T|20|41.0|Non-synonymous|Unprocessed|APF-G1
1542240|IGL00700|7|13357090|Q->Stop|||N/A|||MGI:1196403|Pla2g4c|phospholipase A2, group IVC (cytosolic, calcium-independent) [Source:MGI Symbol;Acc:MGI:1196403]|Heterozygous||C|T|19|40.0|Non-synonymous|Unprocessed|APF-G1
1542241|IGL00700|3|27146835|Disrupted splicing|||N/A|||MGI:95281|Ect2|ect2 oncogene [Source:MGI Symbol;Acc:MGI:95281]|Heterozygous|Homozygous disruption of this locus is embryonic lethal.|A|T|60|41.0|Splice|Unprocessed|APF-G1
1542242|IGL00700|2|150588901|Disrupted splicing|||N/A|||MGI:1919131|2310001a20rik|RIKEN cDNA 2310001A20 gene [Source:MGI Symbol;Acc:MGI:1919131]|Heterozygous||A|G|32|40.0|Splice|Unprocessed|APF-G1
1542644|IGL00701|14|31052248|E->G||1.0|Probably damaging||deleterious|MGI:1923998|Pbrm1|polybromo 1 [Source:MGI Symbol;Acc:MGI:1923998]|Heterozygous|Homozygous null mice display embryonic lethality with hypoplastic cardiac ventricular chambers and malformation of the placenta.|A|G|50|41.0|Non-synonymous|Unprocessed|APF-G1
1542645|IGL00701|12|78626167|Q->K||0.01|Benign|0.89|tolerated|MGI:109602|Gphn|gephyrin [Source:MGI Symbol;Acc:MGI:109602]|Heterozygous|Mice homozygous for disruption of this gene die within one day of birth, apparently due to an inability to suckle.  Apnea also develops within 12 hours of birth.|C|A|40|40.0|Non-synonymous|Unprocessed|APF-G1
1542646|IGL00701|7|25471914|N->I||0.81|Possibly damaging|0.02|deleterious|MGI:1347245|Ceacam1|carcinoembryonic antigen-related cell adhesion molecule 1 [Source:MGI Symbol;Acc:MGI:1347245]|Heterozygous|Mice lacking appreciable levels of the two isoforms containing 4 Ig domains and having increased levels of the two isoforms containing 2 Ig domains are viable and fertile. They are significantly more resistant to mouse hepatitis virus than wild-type mice.|T|A|31|40.0|Non-synonymous|Unprocessed|APF-G1
1542647|IGL00701|1|58535482|V->A||0.11|Benign|1.0|tolerated|MGI:1098784|Fam126b|family with sequence similarity 126, member B [Source:MGI Symbol;Acc:MGI:1098784]|Heterozygous||A|G|29|38.0|Non-synonymous|Unprocessed|APF-G1
1542648|IGL00701|11|53271033|V->I||0.83|Possibly damaging|0.08|tolerated|MGI:1342292|Hspa4|heat shock protein 4 [Source:MGI Symbol;Acc:MGI:1342292]|Heterozygous|Mice homozygous for a knock-out allele exhibit age-dependent neurofibrillary tangles and tau deposits, impaired contextual conditioning, and impaired bar grasping.|C|T|18|40.0|Non-synonymous|Unprocessed|APF-G1
1542649|IGL00701|18|42536342|S->P|||Unknown||deleterious|MGI:1926421|Tcerg1|transcription elongation regulator 1 (CA150) [Source:MGI Symbol;Acc:MGI:1926421]|Heterozygous||T|C|18|38.0|Non-synonymous|Unprocessed|APF-G1
1542650|IGL00701|13|89703726|F->L|||Benign|1.0|tolerated|MGI:102889|Vcan|versican [Source:MGI Symbol;Acc:MGI:102889]|Heterozygous|Homozygotes for an insertional mutation exhibit anterior-posterior segmental defects of the heart, lack endocardial cushions of the conus and atrioventricular region, and die and around embryonic day 10.5.|G|T|16|41.0|Non-synonymous|Unprocessed|APF-G1
1542651|IGL00701|15|82017200|Disrupted splicing|||N/A|||MGI:95606|Xrcc6|X-ray repair complementing defective repair in Chinese hamster cells 6 [Source:MGI Symbol;Acc:MGI:95606]|Heterozygous|Mice homozygous for a knock-out allele exhibit neuron apoptosis, decreased body size, abnormal B and T cell morphology, increased incidence of tumorigenesis, and increased cellular sensitivity to irradiation.|T|C|32|35.0|Splice|Unprocessed|APF-G1
1542652|IGL00701|11|85059125|Disrupted splicing|||N/A|||MGI:2144475|Usp32|ubiquitin specific peptidase 32 [Source:MGI Symbol;Acc:MGI:2144475]|Heterozygous||T|A|25|39.0|Splice|Unprocessed|APF-G1
1543051|IGL00702|5|87125219|N->K|||Benign|0.48|tolerated|MGI:98900|Ugt2b5|UDP glucuronosyltransferase 2 family, polypeptide B5 [Source:MGI Symbol;Acc:MGI:98900]|Heterozygous||A|T|135|39.0|Non-synonymous|Unprocessed|APF-G1
1543052|IGL00702|14|20528250|V->A|||Benign|1.0|tolerated|MGI:107163|Ppp3cb|protein phosphatase 3, catalytic subunit, beta isoform [Source:MGI Symbol;Acc:MGI:107163]|Heterozygous|Homozygous null mice have small hearts and thymi, and reduced body weight. Cardiac function is normal, but mice lack a cardiac hypertrophic response to pressure overload, angiotensin II, or isopreteronol. Thymi are hypoplastic, with abnormal T cell development and reduced numbers of T cells.|A|G|107|37.0|Non-synonymous|Unprocessed|APF-G1
1543053|IGL00702|9|53511831|V->A||0.07|Benign|0.38|tolerated|MGI:107202|Atm|ataxia telangiectasia mutated homolog (human) [Source:MGI Symbol;Acc:MGI:107202]|Heterozygous|Homozygotes for null mutations may exhibit locomotor abnormalities, motor learning deficits, growth retardation, sterility due to meiotic arrest, and susceptibility to thymic lymphomas.|A|G|107|40.0|Non-synonymous|Unprocessed|APF-G1
1543054|IGL00702|4|59596892|K->R||0.09|Benign|0.11|tolerated|MGI:1919729|Hsdl2|hydroxysteroid dehydrogenase like 2 [Source:MGI Symbol;Acc:MGI:1919729]|Heterozygous||A|G|43|39.0|Non-synonymous|Unprocessed|APF-G1
1543055|IGL00702|4|19605421|S->N||0.55|Possibly damaging|0.01|deleterious|MGI:1913552|Fam82b|family with sequence similarity 82, member B [Source:MGI Symbol;Acc:MGI:1913552]|Heterozygous||G|A|42|40.0|Non-synonymous|Unprocessed|APF-G1
1543056|IGL00702|11|99519063|Q->P||0.92|Possibly damaging||deleterious|MGI:3588208|Krt39|keratin 39 [Source:MGI Symbol;Acc:MGI:3588208]|Heterozygous||T|G|41|39.0|Non-synonymous|Unprocessed|APF-G1
1543057|IGL00702|10|33913072|N->Y||0.78|Possibly damaging|0.2|tolerated|MGI:3027894|Rsph4a|radial spoke head 4 homolog A (Chlamydomonas) [Source:MGI Symbol;Acc:MGI:3027894]|Heterozygous||A|T|28|40.0|Non-synonymous|Unprocessed|APF-G1
1543058|IGL00702|2|69708545|V->I||0.94|Possibly damaging|0.24|tolerated|MGI:2444596|Fastkd1|FAST kinase domains 1 [Source:MGI Symbol;Acc:MGI:2444596]|Heterozygous||C|T|17|40.0|Non-synonymous|Unprocessed|APF-G1
1543059|IGL00702|15|7185739|Disrupted splicing|||N/A|||MGI:96788|Lifr|leukemia inhibitory factor receptor [Source:MGI Symbol;Acc:MGI:96788]|Heterozygous|Homozygotes for targeted null mutations die as neonates with reduced numbers of facial and spinal motor neurons, neurons of the nucleus ambiguus, and astrocytes. Mutants also show impaired placentation, severe osteopenia, and low hepatic glycogen stores.|T|C|16|37.0|Splice|Unprocessed|APF-G1
1543578|IGL00703|8|43520179|D->E||1.0|Probably damaging|0.03|deleterious|MGI:3588304|Adam26b|a disintegrin and metallopeptidase domain 26B [Source:MGI Symbol;Acc:MGI:3588304]|Heterozygous||A|T|123|40.0|Non-synonymous|Unprocessed|APF-G1
1543579|IGL00703|14|76504828|R->G||0.83|Possibly damaging|0.05|deleterious|MGI:109127|Tsc22d1|TSC22 domain family, member 1 [Source:MGI Symbol;Acc:MGI:109127]|Heterozygous|Mcie homozygous for a null allele exhibit increased proliferation of bone marrow cells and decreased kidney and heart weights.|A|G|76|39.0|Non-synonymous|Unprocessed|APF-G1
1543580|IGL00703|6|14718408|T->A||0.04|Benign|0.48|tolerated|MGI:2153588|Ppp1r3a|protein phosphatase 1, regulatory (inhibitor) subunit 3A [Source:MGI Symbol;Acc:MGI:2153588]|Heterozygous|Homozygous mutant mice have reduced levels of skeletal muscle glycogen. Whereas one model was normoglycemic and grossly normal, another on a similar genetic background was glucose intolerant, insulin resistant, and gained weight to the point of obesity.|T|C|62|39.0|Non-synonymous|Unprocessed|APF-G1
1543581|IGL00703|5|87008192|Y->F||0.13|Benign|0.04|deleterious|MGI:3576100|Ugt2b35|UDP glucuronosyltransferase 2 family, polypeptide B35 [Source:MGI Symbol;Acc:MGI:3576100]|Heterozygous||A|T|58|39.0|Non-synonymous|Unprocessed|APF-G1
1543582|IGL00703|14|38370801|D->V||0.85|Possibly damaging|0.01|deleterious|MGI:1097165|Nrg3|neuregulin 3 [Source:MGI Symbol;Acc:MGI:1097165]|Heterozygous|Mutations in this gene result in abnormal, genetic background specific, mammary gland development.|T|A|57|38.0|Non-synonymous|Unprocessed|APF-G1
1543583|IGL00703|13|113045513|N->D||0.5|Possibly damaging|0.04|deleterious|MGI:1916840|Gpx8|glutathione peroxidase 8 (putative) [Source:MGI Symbol;Acc:MGI:1916840]|Heterozygous||T|C|52|39.0|Non-synonymous|Unprocessed|APF-G1
1543584|IGL00703|8|26125918|N->S||0.18|Benign|0.34|tolerated|MGI:1924983|Rnf170|ring finger protein 170 [Source:MGI Symbol;Acc:MGI:1924983]|Heterozygous||A|G|50|40.0|Non-synonymous|Unprocessed|APF-G1
1543585|IGL00703|13|102770767|E->Stop|||N/A|||MGI:1918885|Mast4|microtubule associated serine/threonine kinase family member 4 [Source:MGI Symbol;Acc:MGI:1918885]|Heterozygous||C|A|42|39.5|Non-synonymous|Unprocessed|APF-G1
1543586|IGL00703|16|36757791|I->V|||Benign|0.62|tolerated|MGI:1890457|Slc15a2|solute carrier family 15 (H+/peptide transporter), member 2 [Source:MGI Symbol;Acc:MGI:1890457]|Heterozygous|Homozygous mutant mice have impairments of dipeptide transportion, however, show no gross defects.|T|C|33|41.0|Non-synonymous|Unprocessed|APF-G1
1543587|IGL00703|6|124914956|K->E|||Unknown|||MGI:1916452|Ptms|parathymosin [Source:MGI Symbol;Acc:MGI:1916452]|Heterozygous||T|C|33|37.0|Non-synonymous|Unprocessed|APF-G1
1543588|IGL00703|1|74423960|L->P||0.9|Possibly damaging|0.29|tolerated|MGI:98930|Vil1|villin 1 [Source:MGI Symbol;Acc:MGI:98930]|Heterozygous|Homozygous null mutants do not exhibit gross abnormalities or apparent defects of microvilli morphogenesis, however in one line, an increased sensitivity to colitis induced by dextran sulfate was observed.|T|C|27|38.0|Non-synonymous|Unprocessed|APF-G1
1543589|IGL00703|4|25280631|V->A|||Benign|0.01|deleterious|MGI:1914740|1810074p20rik|RIKEN cDNA 1810074P20 gene [Source:MGI Symbol;Acc:MGI:1914740]|Heterozygous||A|G|23|38.0|Non-synonymous|Unprocessed|APF-G1
1543590|IGL00703|15|66696489|V->I||0.06|Benign|0.5|tolerated|MGI:98733|Tg|thyroglobulin [Source:MGI Symbol;Acc:MGI:98733]|Heterozygous|Mice homozygous for a spontaneous mutation exhibit enlarged thyroid gland, hypothyroidism, abnormal thyroid gland morphology, and decreased body weight.|G|A|22|40.0|Non-synonymous|Unprocessed|APF-G1
1543591|IGL00703|6|141655352|T->S||1.0|Probably damaging|0.09|tolerated|MGI:1351899|Slco1b2|solute carrier organic anion transporter family, member 1b2 [Source:MGI Symbol;Acc:MGI:1351899]|Heterozygous|Mice homozygous for a null mutation display slight abnormalities in blood chemistry and are resistant to injury induced by some classes of hepatotoxins.|A|T|19|40.0|Non-synonymous|Unprocessed|APF-G1
1543592|IGL00703|12|105592355|V->A|||Benign|0.04|deleterious|MGI:102845|Bdkrb2|bradykinin receptor, beta 2 [Source:MGI Symbol;Acc:MGI:102845]|Heterozygous|Homozygous null mutants are indistinguishable from normal littermates, but bradykinin response is eliminated in ileum, uterus, and cervical ganglia.|T|C|16|35.0|Non-synonymous|Unprocessed|APF-G1
1543593|IGL00703|3|116927391|Disrupted splicing|||N/A|||MGI:2148896|Palmd|palmdelphin [Source:MGI Symbol;Acc:MGI:2148896]|Heterozygous||A|G|113|40.0|Splice|Unprocessed|APF-G1
1543594|IGL00703|10|88525108|Disrupted splicing|||N/A|||MGI:1336213|Mybpc1|myosin binding protein C, slow-type [Source:MGI Symbol;Acc:MGI:1336213]|Heterozygous||T|C|85|40.0|Splice|Unprocessed|APF-G1
1543595|IGL00703|1|131255302|Disrupted splicing|||N/A|||MGI:1929612|Ikbke|inhibitor of kappaB kinase epsilon [Source:MGI Symbol;Acc:MGI:1929612]|Heterozygous|Homozygous null mice are viable and fertile.|A|T|56|39.0|Splice|Unprocessed|APF-G1
1543596|IGL00703|3|95232545|Disrupted splicing|||N/A|||MGI:1889510|Cdc42se1|CDC42 small effector 1 [Source:MGI Symbol;Acc:MGI:1889510]|Heterozygous||A|G|28|38.0|Splice|Unprocessed|APF-G1
1543597|IGL00703|13|106953430|Disrupted splicing|||N/A|||MGI:1913504|Dimt1|DIM1 dimethyladenosine transferase 1-like (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1913504]|Heterozygous||T|C|21|40.0|Splice|Unprocessed|APF-G1
1544124|IGL00704|1|82858403|T->I||0.97|Probably damaging||deleterious|MGI:1333754|Agfg1|ArfGAP with FG repeats 1 [Source:MGI Symbol;Acc:MGI:1333754]|Heterozygous|Male mice homozygous for disruptions in this gene are infertile as a result of abnormalities in spermatogenesis.  Otherwise, males and females are normal andlive a normal life span.|C|T|116|41.0|Non-synonymous|Unprocessed|APF-G1
1544125|IGL00704|5|8686257|I->F||0.46|Possibly damaging|0.07|tolerated|MGI:97570|Abcb1a|ATP-binding cassette, sub-family B (MDR/TAP), member 1A [Source:MGI Symbol;Acc:MGI:97570]|Heterozygous|Mutations in this gene result in increased sensitivity to various drugs, including avermectins and vinblastine.|A|T|48|41.0|Non-synonymous|Unprocessed|APF-G1
1544126|IGL00704|1|30804838|G->D|||Benign|0.87|tolerated|MGI:2446126|Phf3|PHD finger protein 3 [Source:MGI Symbol;Acc:MGI:2446126]|Heterozygous||C|T|45|37.0|Non-synonymous|Unprocessed|APF-G1
1544127|IGL00704|17|15732565|V->A||0.21|Benign|0.01|deleterious|MGI:88393|Chd1|chromodomain helicase DNA binding protein 1 [Source:MGI Symbol;Acc:MGI:88393]|Heterozygous||T|C|37|39.0|Non-synonymous|Unprocessed|APF-G1
1544128|IGL00704|1|194751461|V->E||0.01|Benign|0.05|deleterious|MGI:107684|Plxna2|plexin A2 [Source:MGI Symbol;Acc:MGI:107684]|Heterozygous|Mice homozygous for a knock-out allele show abnormal granule cell migration in the adult cerebellum and aberrant projection of mossy fibers in hippocampal slices. Mice homozygous for an ENU-induced allele are smaller and show granule cell migration defects and mild ataxia with incomplete penetrance.|T|A|29|39.0|Non-synonymous|Unprocessed|APF-G1
1544129|IGL00704|7|34158869|N->S||1.0|Probably damaging|0.01|deleterious|MGI:1858313|Uba2|ubiquitin-like modifier activating enzyme 2 [Source:MGI Symbol;Acc:MGI:1858313]|Heterozygous||T|C|29|38.0|Non-synonymous|Unprocessed|APF-G1
1544130|IGL00704|11|116858496|F->L||0.06|Benign|0.32|tolerated|MGI:1917150|Mfsd11|major facilitator superfamily domain containing 11 [Source:MGI Symbol;Acc:MGI:1917150]|Heterozygous||T|C|25|37.0|Non-synonymous|Unprocessed|APF-G1
1544131|IGL00704|7|23343140|D->V||0.99|Probably damaging||deleterious|MGI:3056600|Nlrp4e|NLR family, pyrin domain containing 4E [Source:MGI Symbol;Acc:MGI:3056600]|Heterozygous||A|T|25|38.0|Non-synonymous|Unprocessed|APF-G1
1544132|IGL00704|5|24439068|I->L||0.97|Probably damaging|0.09|tolerated|MGI:109351|Slc4a2|solute carrier family 4 (anion exchanger), member 2 [Source:MGI Symbol;Acc:MGI:109351]|Heterozygous|Mice homozygous for a mutant allele display male infertility associated with disrupted spermiogenesis and germ cell apoptosis.  However, mice homozygous for a null allele display perinatal and postnatal lethality, loss of gastric acid secretion, failure of tooth eruption, aphagia, and deafness.|A|C|23|36.0|Non-synonymous|Unprocessed|APF-G1
1544133|IGL00704|18|3423487|V->A|||Benign|0.81|tolerated|MGI:1918995|Cul2|cullin 2 [Source:MGI Symbol;Acc:MGI:1918995]|Heterozygous||T|C|22|40.0|Non-synonymous|Unprocessed|APF-G1
1544134|IGL00704|2|18872336|T->K||0.2|Benign|0.01|deleterious|MGI:1298206|Pip4k2a|phosphatidylinositol-5-phosphate 4-kinase, type II, alpha [Source:MGI Symbol;Acc:MGI:1298206]|Heterozygous||G|T|21|39.0|Non-synonymous|Unprocessed|APF-G1
1544135|IGL00704|18|43261249|Y->H||1.0|Probably damaging||deleterious|MGI:2442403|Stk32a|serine/threonine kinase 32A [Source:MGI Symbol;Acc:MGI:2442403]|Heterozygous||T|C|19|37.0|Non-synonymous|Unprocessed|APF-G1
1544136|IGL00704|2|128663984|V->E||0.28|Benign|0.06|tolerated|MGI:103097|Anapc1|anaphase promoting complex subunit 1 [Source:MGI Symbol;Acc:MGI:103097]|Heterozygous||A|T|19|39.0|Non-synonymous|Unprocessed|APF-G1
1544137|IGL00704|2|181234385|C->R||1.0|Probably damaging||deleterious|MGI:2385169|Bc006779|cDNA sequence BC006779 [Source:MGI Symbol;Acc:MGI:2385169]|Heterozygous||A|G|16|35.0|Non-synonymous|Unprocessed|APF-G1
1544138|IGL00704|6|4607979|Disrupted splicing|||N/A|||MGI:2384865|Casd1|CAS1 domain containing 1 [Source:MGI Symbol;Acc:MGI:2384865]|Heterozygous||A|T|40|40.0|Splice|Unprocessed|APF-G1
1544627|IGL00705|18|4379670|N->H||0.69|Possibly damaging|0.01|deleterious|MGI:1914690|Mtpap|mitochondrial poly(A) polymerase [Source:MGI Symbol;Acc:MGI:1914690]|Heterozygous||A|C|161|40.0|Non-synonymous|Unprocessed|APF-G1
1544628|IGL00705|7|103250438|T->I|||Benign|0.33|tolerated|MGI:3051372|Dub2a|deubiquitinating enzyme 2a [Source:MGI Symbol;Acc:MGI:3051372]|Heterozygous||G|A|101|38.0|Non-synonymous|Unprocessed|APF-G1
1544629|IGL00705|1|6244133|M->K||0.05|Benign|0.11|tolerated|MGI:1341850|Rb1cc1|RB1-inducible coiled-coil 1 [Source:MGI Symbol;Acc:MGI:1341850]|Heterozygous|Homozygous mutation of this gene results in embryonic lethality at mid/late gestation associated with heart failure and liver degeneration.|T|A|90|40.0|Non-synonymous|Unprocessed|APF-G1
1544630|IGL00705|8|124036637|V->D||0.01|Benign|0.6|tolerated|MGI:2681124|Urb2|URB2 ribosome biogenesis 2 homolog (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:2681124]|Heterozygous||T|A|69|39.0|Non-synonymous|Unprocessed|APF-G1
1544631|IGL00705|11|108472033|T->K|||Benign|1.0|tolerated|MGI:1923673|Ccdc46|coiled-coil domain containing 46 [Source:MGI Symbol;Acc:MGI:1923673]|Heterozygous||C|A|63|40.0|Non-synonymous|Unprocessed|APF-G1
1544632|IGL00705|8|33581592|P->Q|||N/A||deleterious|MGI:1934816|Tex15|testis expressed gene 15 [Source:MGI Symbol;Acc:MGI:1934816]|Heterozygous|Male mice are infertile due to arrest of meiosis stemming from failure to repair double-strand breaks.  However, female mice are fertile.|C|A|52|40.5|Non-synonymous|Unprocessed|APF-G1
1544633|IGL00705|7|15833737|S->T|||N/A|0.4|tolerated|MGI:2149036|Obox6|oocyte specific homeobox 6 [Source:MGI Symbol;Acc:MGI:2149036]|Heterozygous|Mice homozygous for a null allele exhibit no detectable abnormal phenotype.|A|T|47|38.0|Non-synonymous|Unprocessed|APF-G1
1544634|IGL00705|7|12849159|H->R||0.12|Benign|0.39|tolerated|MGI:1890378|Zfp110|zinc finger protein 110 [Source:MGI Symbol;Acc:MGI:1890378]|Heterozygous|Homozygous mutants on a C57BL/6 background die at embryonic day 12. On a strain 129 background, mutants are viable and fertile, but males are more docile and testis weight is greatly reduced. On an F2 background, 20% of homozygous pups die neonatally.|A|G|43|39.0|Non-synonymous|Unprocessed|APF-G1
1544635|IGL00705|1|163079503|S->P||0.96|Probably damaging|0.12|tolerated|MGI:1925508|4921528o07rik|RIKEN cDNA 4921528O07 gene [Source:MGI Symbol;Acc:MGI:1925508]|Heterozygous||A|G|38|39.0|Non-synonymous|Unprocessed|APF-G1
1544636|IGL00705|14|35445887|I->N||0.94|Possibly damaging|0.01|deleterious|MGI:95812|Grid1|glutamate receptor, ionotropic, delta 1 [Source:MGI Symbol;Acc:MGI:95812]|Heterozygous|Homozygotes for a targeted null mutation display a significant high-frequency hearing loss, associated with reductions of both cochlear outer hair cell function and endolymphatic potential, as well as increased vulnerability to acoustic injury.|T|A|34|40.0|Non-synonymous|Unprocessed|APF-G1
1544637|IGL00705|1|53348451|C->S||1.0|Probably damaging|0.01|deleterious|MGI:1917646|Asnsd1|asparagine synthetase domain containing 1 [Source:MGI Symbol;Acc:MGI:1917646]|Heterozygous||A|T|29|38.0|Non-synonymous|Unprocessed|APF-G1
1544638|IGL00705|9|3359588|H->Q||1.0|Probably damaging||deleterious|MGI:1914917|Alkbh8|alkB, alkylation repair homolog 8 (E. coli) [Source:MGI Symbol;Acc:MGI:1914917]|Heterozygous|Homozygous mutants show no obvious phenotype at 20 months of age.|T|A|27|41.0|Non-synonymous|Unprocessed|APF-G1
1544639|IGL00705|6|83977130|T->A||0.07|Benign|0.05|deleterious|MGI:1203484|Zfml|zinc finger, matrin-like [Source:MGI Symbol;Acc:MGI:1203484]|Heterozygous||A|G|24|38.0|Non-synonymous|Unprocessed|APF-G1
1544640|IGL00705|17|46412472|S->R||0.28|Benign|||MGI:1889348|Zfp318|zinc finger protein 318 [Source:MGI Symbol;Acc:MGI:1889348]|Heterozygous||T|A|23|39.0|Non-synonymous|Unprocessed|APF-G1
1544641|IGL00705|5|62678023|H->Q||1.0|Probably damaging||deleterious|MGI:2684416|Arap2|ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 [Source:MGI Symbol;Acc:MGI:2684416]|Heterozygous||A|T|23|40.0|Non-synonymous|Unprocessed|APF-G1
1544642|IGL00705|5|66993153|R->Stop|||N/A|||MGI:1924819|Limch1|LIM and calponin homology domains 1 [Source:MGI Symbol;Acc:MGI:1924819]|Heterozygous||A|T|23|40.0|Non-synonymous|Unprocessed|APF-G1
1544643|IGL00705|5|33735140|I->V||0.26|Benign|0.02|deleterious|MGI:95524|Fgfr3|fibroblast growth factor receptor 3 [Source:MGI Symbol;Acc:MGI:95524]|Heterozygous|Mice homozygous for a null allele abnormal skeletal development, decreased body size, and premature death.|A|G|19|39.0|Non-synonymous|Unprocessed|APF-G1
1544644|IGL00705|5|88621350|I->V||0.57|Possibly damaging|0.08|tolerated|MGI:106484|Rufy3|RUN and FYVE domain containing 3 [Source:MGI Symbol;Acc:MGI:106484]|Heterozygous||A|G|17|39.0|Non-synonymous|Unprocessed|APF-G1
1544645|IGL00705|11|107095708|Disrupted splicing|||N/A|||MGI:2444008|Bptf|bromodomain PHD finger transcription factor [Source:MGI Symbol;Acc:MGI:2444008]|Heterozygous|Mice homozygous for a null mutation display embryonic lethality during organogenesis with embryonic growth arrest around early gastrulation and a greatly reduced ectoplacental cone.|T|C|119|39.0|Splice|Unprocessed|APF-G1
1544646|IGL00705|3|96707200|Disrupted splicing|||N/A|||MGI:1925623|Nudt17|nudix (nucleoside diphosphate linked moiety X)-type motif 17 [Source:MGI Symbol;Acc:MGI:1925623]|Heterozygous||A|G|32|37.0|Splice|Unprocessed|APF-G1
1545166|IGL00706|19|9013730|S->Stop|||N/A|||MGI:1316648|Ahnak|AHNAK nucleoprotein (desmoyokin) [Source:MGI Symbol;Acc:MGI:1316648]|Heterozygous|Mice homozygous for one knock-out allele exhibit decreaed T cell proliferation and increased susceptibility to parasitic infection.|C|A|82|41.0|Non-synonymous|Unprocessed|APF-G1
1545167|IGL00706|6|102203949|V->I||0.19|Benign|0.34|tolerated|MGI:99534|Cntn3|contactin 3 [Source:MGI Symbol;Acc:MGI:99534]|Heterozygous||C|T|45|39.0|Non-synonymous|Unprocessed|APF-G1
1545168|IGL00706|7|140769153|I->T|||Benign|1.0|tolerated|MGI:88607|Cyp2e1|cytochrome P450, family 2, subfamily e, polypeptide 1 [Source:MGI Symbol;Acc:MGI:88607]|Heterozygous|Mice homozygous for a null allele exhibit altered responses to xenobiotics including decreased urethane-induced tumors and allylnitrile- or acetamenophen-associated mortality but increased allylnitrile-induced vestibular function loss.|T|C|44|35.5|Non-synonymous|Unprocessed|APF-G1
1545169|IGL00706|19|11283778|V->I||0.3|Benign|0.22|tolerated|MGI:2670985|Ms4a5|membrane-spanning 4-domains, subfamily A, member 5 [Source:MGI Symbol;Acc:MGI:2670985]|Heterozygous||C|T|43|39.0|Non-synonymous|Unprocessed|APF-G1
1545170|IGL00706|7|27155158|I->T||0.09|Benign|0.46|tolerated|MGI:2686296|Cyp2t4|cytochrome P450, family 2, subfamily t, polypeptide 4 [Source:MGI Symbol;Acc:MGI:2686296]|Heterozygous||T|C|37|37.0|Non-synonymous|Unprocessed|APF-G1
1545171|IGL00706|6|120406636|D->E||0.44|Possibly damaging|0.8|tolerated|MGI:2136980|Kdm5a|lysine (K)-specific demethylase 5A [Source:MGI Symbol;Acc:MGI:2136980]|Heterozygous|Mice homozygous for a knock-out allele exhibit reduced body size, abnormal involuntary movement and quantitative changes in the hematopoietic stem cell and myeloid progenitor compartments, consistent with enhanced survival and increased cycling. Neonatal survival is sensitive to genetic background.|T|A|32|39.5|Non-synonymous|Unprocessed|APF-G1
1545172|IGL00706|18|44107805|C->Y||1.0|Probably damaging||deleterious|MGI:1925492|Spink12|serine peptidase inhibitor, Kazal type 11 [Source:MGI Symbol;Acc:MGI:1925492]|Heterozygous||G|A|30|38.5|Non-synonymous|Unprocessed|APF-G1
1545173|IGL00706|19|34618882|T->S||0.26|Benign|0.61|tolerated|MGI:2148249|2010002m12rik|RIKEN cDNA 2010002M12 gene [Source:MGI Symbol;Acc:MGI:2148249]|Heterozygous||T|A|30|39.0|Non-synonymous|Unprocessed|APF-G1
1545174|IGL00706|2|21746773|L->P||1.0|Probably damaging||deleterious|MGI:2441697|Gpr158|G protein-coupled receptor 158 [Source:MGI Symbol;Acc:MGI:2441697]|Heterozygous||T|C|29|40.0|Non-synonymous|Unprocessed|APF-G1
1545175|IGL00706|16|22935696|T->A||0.8|Possibly damaging|0.04|deleterious|MGI:1890221|Fetub|fetuin beta [Source:MGI Symbol;Acc:MGI:1890221]|Heterozygous||A|G|28|39.0|Non-synonymous|Unprocessed|APF-G1
1545176|IGL00706|18|39286551|N->K||1.0|Probably damaging||deleterious|MGI:1918552|Arhgap26|Rho GTPase activating protein 26 [Source:MGI Symbol;Acc:MGI:1918552]|Heterozygous||T|A|25|41.0|Non-synonymous|Unprocessed|APF-G1
1545177|IGL00706|9|21977239|F->S||1.0|Probably damaging||deleterious|MGI:1918996|Rgl3|ral guanine nucleotide dissociation stimulator-like 3 [Source:MGI Symbol;Acc:MGI:1918996]|Heterozygous||A|G|25|35.0|Non-synonymous|Unprocessed|APF-G1
1545178|IGL00706|5|146211905|D->G||0.05|Benign|0.05|deleterious|MGI:1921382|Rnf6|ring finger protein (C3H2C3 type) 6 [Source:MGI Symbol;Acc:MGI:1921382]|Heterozygous||T|C|19|37.0|Non-synonymous|Unprocessed|APF-G1
1545179|IGL00706|1|71031426|R->H||0.5|Possibly damaging|0.42|tolerated|MGI:1328361|Bard1|BRCA1 associated RING domain 1 [Source:MGI Symbol;Acc:MGI:1328361]|Heterozygous|Mice homozygous for disruptions of this gene fail to develop past the egg cylinder stage.  The phenotype is similar to that of mice with homozygous for disruptions in Brca1 or homozygous for disruptions in both Bard1 and Brca1.|C|T|18|39.0|Non-synonymous|Unprocessed|APF-G1
1545180|IGL00706|1|166100552|E->G|||Benign|0.55|tolerated|MGI:2685055|Dusp27|dual specificity phosphatase 27 (putative) [Source:MGI Symbol;Acc:MGI:2685055]|Heterozygous||T|C|18|38.0|Non-synonymous|Unprocessed|APF-G1
1545181|IGL00706|3|62496842|C->S||1.0|Probably damaging||deleterious|MGI:1919412|Dhx36|DEAH (Asp-Glu-Ala-His) box polypeptide 36 [Source:MGI Symbol;Acc:MGI:1919412]|Heterozygous||A|T|17|39.0|Non-synonymous|Unprocessed|APF-G1
1545182|IGL00706|X|75005359|S->N||0.06|Benign|0.43|tolerated|MGI:2387324|Gab3|growth factor receptor bound protein 2-associated protein 3 [Source:MGI Symbol;Acc:MGI:2387324]|Heterozygous|Females homozygous and males hemizygous for disruptions in this X-linked gene developed normally, exhibted normal hematopoiesis, and were immunocompetent.|C|T|17|39.0|Non-synonymous|Unprocessed|APF-G1
1545183|IGL00706|3|100148100|Disrupted splicing|||N/A|||MGI:2443143|Wdr3|WD repeat domain 3 [Source:MGI Symbol;Acc:MGI:2443143]|Heterozygous||G|A|17|39.0|Splice|Unprocessed|APF-G1
1545703|IGL00707|11|72178504|T->K||1.0|Probably damaging||deleterious|MGI:1921727|4933427d14rik|RIKEN cDNA 4933427D14 gene [Source:MGI Symbol;Acc:MGI:1921727]|Heterozygous||G|T|59|39.0|Non-synonymous|Unprocessed|APF-G1
1545704|IGL00707|19|57673265|Y->F||0.93|Possibly damaging|0.06|tolerated|MGI:2147749|Atrnl1|attractin like 1 [Source:MGI Symbol;Acc:MGI:2147749]|Heterozygous|Mice homozygous for a null allele exhibit normal coat coloring and normal brain morphology.|A|T|54|40.0|Non-synonymous|Unprocessed|APF-G1
1545705|IGL00707|X|151860734|S->T||1.0|Probably damaging|0.02|deleterious|MGI:1926884|Huwe1|HECT, UBA and WWE domain containing 1 [Source:MGI Symbol;Acc:MGI:1926884]|Heterozygous|Mice homozygous for a conditional allele activated in neurons results in neonatal lethality, poorly developed dentate gyrus, small cerebellum, increased cortex density, and increased neuronal precursor cell proliferation.|T|A|49|38.0|Non-synonymous|Unprocessed|APF-G1
1545706|IGL00707|10|85878516|H->Q||1.0|Probably damaging||deleterious|MGI:1914735|Pwp1|PWP1 homolog (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1914735]|Heterozygous||T|A|39|39.0|Non-synonymous|Unprocessed|APF-G1
1545707|IGL00707|16|20689014|R->Q||1.0|Probably damaging||deleterious|MGI:2384784|Eif4g1|eukaryotic translation initiation factor 4, gamma 1 [Source:MGI Symbol;Acc:MGI:2384784]|Heterozygous||G|A|39|39.0|Non-synonymous|Unprocessed|APF-G1
1545708|IGL00707|11|9291586|T->S||1.0|Probably damaging|||MGI:2388707|Abca13|ATP-binding cassette, sub-family A (ABC1), member 13 [Source:MGI Symbol;Acc:MGI:2388707]|Heterozygous||A|T|33|37.0|Non-synonymous|Unprocessed|APF-G1
1545709|IGL00707|3|152449043|L->Stop|||N/A|||MGI:1920453|Zzz3|zinc finger, ZZ domain containing 3 [Source:MGI Symbol;Acc:MGI:1920453]|Heterozygous||T|A|30|39.5|Non-synonymous|Unprocessed|APF-G1
1545710|IGL00707|7|120133413|A->T||0.01|Benign|1.0|tolerated|MGI:99214|Zp2|zona pellucida glycoprotein 2 [Source:MGI Symbol;Acc:MGI:99214]|Heterozygous|Female homozygous mutants exhibit a thin zona pellucida matrix in early ovarian follicles that becomes disassociated in pre-ovulatory follicles. Few oocytes are produced, and any that are fertilized fail to survive to the two-cell stage.|C|T|29|39.0|Non-synonymous|Unprocessed|APF-G1
1545711|IGL00707|4|132580258|T->A||0.01|Benign|0.02|deleterious|MGI:106066|Ptafr|platelet-activating factor receptor [Source:MGI Symbol;Acc:MGI:106066]|Heterozygous|Inactivation of this locus affects the immune response. Homozygotes have a marked reduction in systemic anaphylactic symptoms but are otherwise healthy. Further studies showed delayed elimination of parasites, and resistance to pneumonococcal pneumonia infection.|A|G|25|38.0|Non-synonymous|Unprocessed|APF-G1
1545712|IGL00707|4|83681155|M->L|||Benign|1.0|tolerated|MGI:1922152|4930473a06rik|RIKEN cDNA 4930473A06 gene [Source:MGI Symbol;Acc:MGI:1922152]|Heterozygous||A|T|24|39.0|Non-synonymous|Unprocessed|APF-G1
1545713|IGL00707|9|36696608|T->I||0.45|Possibly damaging|0.01|deleterious|MGI:104590|Acrv1|acrosomal vesicle protein 1 [Source:MGI Symbol;Acc:MGI:104590]|Heterozygous||C|T|20|38.5|Non-synonymous|Unprocessed|APF-G1
1545714|IGL00707|10|21148384|E->V||1.0|Probably damaging||deleterious|MGI:97249|Myb|myeloblastosis oncogene [Source:MGI Symbol;Acc:MGI:97249]|Heterozygous|Mice homozygous for deficient alleles of this gene display severe hematopoietic abnormalities. Red and white blood cells and platelets are all affected.|T|A|19|38.0|Non-synonymous|Unprocessed|APF-G1
1545715|IGL00707|1|51133053|Disrupted splicing|||N/A|||MGI:1861735|Tmeff2|transmembrane protein with EGF-like and two follistatin-like domains 2 [Source:MGI Symbol;Acc:MGI:1861735]|Heterozygous||A|G|36|39.5|Splice|Unprocessed|APF-G1
1545716|IGL00707|1|169522435|Disrupted splicing|||N/A|||MGI:1914227|Nuf2|NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1914227]|Heterozygous||T|A|19|39.0|Splice|Unprocessed|APF-G1
1546212|IGL00708|14|105159960|V->I|||Unknown|0.01|deleterious|MGI:1921463|Rbm26|RNA binding motif protein 26 [Source:MGI Symbol;Acc:MGI:1921463]|Heterozygous||C|T|171|41.0|Non-synonymous|Unprocessed|APF-G1
1546213|IGL00708|9|72312135|V->A||0.01|Benign|0.04|deleterious|MGI:2384583|Zfp280d|zinc finger protein 280D [Source:MGI Symbol;Acc:MGI:2384583]|Heterozygous||T|C|160|40.0|Non-synonymous|Unprocessed|APF-G1
1546214|IGL00708|16|15779426|I->V||0.06|Benign|0.14|tolerated|MGI:104779|Prkdc|protein kinase, DNA activated, catalytic polypeptide [Source:MGI Symbol;Acc:MGI:104779]|Heterozygous|Mutations at this locus effect genome stability, radiation sensitivity and DNA repair. Nonsense (scid) and null homozygotes have severe combined immunodeficiency. A BALB/c variant allele reduces enzyme activity and predisposes to breast cancer.|A|G|122|40.0|Non-synonymous|Unprocessed|APF-G1
1546215|IGL00708|18|42571125|N->K||0.14|Benign|0.44|tolerated|MGI:1926421|Tcerg1|transcription elongation regulator 1 (CA150) [Source:MGI Symbol;Acc:MGI:1926421]|Heterozygous||T|A|120|41.0|Non-synonymous|Unprocessed|APF-G1
1546216|IGL00708|2|115864244|D->N||0.01|Benign|0.27|tolerated|MGI:108564|Meis2|Meis homeobox 2 [Source:MGI Symbol;Acc:MGI:108564]|Heterozygous||C|T|69|39.0|Non-synonymous|Unprocessed|APF-G1
1546217|IGL00708|7|44581421|T->A|||Benign|1.0|tolerated|MGI:109365|Napsa|napsin A aspartic peptidase [Source:MGI Symbol;Acc:MGI:109365]|Heterozygous||A|G|52|37.0|Non-synonymous|Unprocessed|APF-G1
1546218|IGL00708|8|41084349|T->I||0.98|Probably damaging||deleterious|MGI:2142572|Mtus1|mitochondrial tumor suppressor 1 [Source:MGI Symbol;Acc:MGI:2142572]|Heterozygous||G|A|42|40.0|Non-synonymous|Unprocessed|APF-G1
1546219|IGL00708|18|20461326|V->D||0.87|Possibly damaging||deleterious|MGI:2661061|Dsg4|desmoglein 4 [Source:MGI Symbol;Acc:MGI:2661061]|Heterozygous|Mice carrying mutations at this locus exhibit abnormalities in hair growth, vibrissae growth, and a thickened epidermis.|T|A|36|38.5|Non-synonymous|Unprocessed|APF-G1
1546220|IGL00708|4|47383992|T->I|||Benign|0.26|tolerated|MGI:98728|Tgfbr1|transforming growth factor, beta receptor I [Source:MGI Symbol;Acc:MGI:98728]|Heterozygous|Homozygotes for some targeted null mutations exhibit defects of the yolk sac and placenta, lack circulating erythrocytes, and die at midgestation. Mutant endothelial cells show enhanced proliferation, improper migration, and reduced fibronectin production.|C|T|35|40.0|Non-synonymous|Unprocessed|APF-G1
1546221|IGL00708|17|85078507|Y->C||1.0|Probably damaging|0.01|deleterious|MGI:2441932|Prepl|prolyl endopeptidase-like [Source:MGI Symbol;Acc:MGI:2441932]|Heterozygous||T|C|33|39.0|Non-synonymous|Unprocessed|APF-G1
1546222|IGL00708|4|137421969|L->F|||Benign|0.48|tolerated|MGI:1915118|Cela3b|chymotrypsin-like elastase family, member 3B [Source:MGI Symbol;Acc:MGI:1915118]|Heterozygous||C|A|31|39.0|Non-synonymous|Unprocessed|APF-G1
1546223|IGL00708|6|122047487|E->G||0.94|Possibly damaging|0.09|tolerated|MGI:99836|Mug2|murinoglobulin 2 [Source:MGI Symbol;Acc:MGI:99836]|Heterozygous||A|G|31|41.0|Non-synonymous|Unprocessed|APF-G1
1546224|IGL00708|19|56813447|S->R||0.01|Benign|0.17|tolerated|MGI:2445022|A630007b06rik|RIKEN cDNA A630007B06 gene [Source:MGI Symbol;Acc:MGI:2445022]|Heterozygous||A|T|29|40.0|Non-synonymous|Unprocessed|APF-G1
1546225|IGL00708|12|71072728|S->P|||Benign|0.08|tolerated|MGI:2444354|Arid4a|AT rich interactive domain 4A (RBP1-like) [Source:MGI Symbol;Acc:MGI:2444354]|Heterozygous|Mice homozygous for a knock-out allelle exhibit altered DNA methylation patterns, disrupted hematopoeisis and a portion develop acute myeloid leukemia.|T|C|26|39.0|Non-synonymous|Unprocessed|APF-G1
1546226|IGL00708|18|63778033|T->M||0.78|Possibly damaging||deleterious|MGI:1860197|Wdr7|WD repeat domain 7 [Source:MGI Symbol;Acc:MGI:1860197]|Heterozygous||C|T|26|38.0|Non-synonymous|Unprocessed|APF-G1
1546227|IGL00708|7|66968902|E->G||1.0|Probably damaging||deleterious|MGI:3588195|Adamts17|a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 17 [Source:MGI Symbol;Acc:MGI:3588195]|Heterozygous||A|G|20|38.0|Non-synonymous|Unprocessed|APF-G1
1546228|IGL00708|11|87186393|D->E||1.0|Probably damaging|0.07|tolerated|MGI:2153072|Trim37|tripartite motif-containing 37 [Source:MGI Symbol;Acc:MGI:2153072]|Heterozygous||T|A|19|41.0|Non-synonymous|Unprocessed|APF-G1
1546229|IGL00708|2|157220170|S->P||0.98|Probably damaging|0.12|tolerated|MGI:3603828|4922505g16rik|RIKEN cDNA 4922505G16 gene [Source:MGI Symbol;Acc:MGI:3603828]|Heterozygous||A|G|17|40.0|Non-synonymous|Unprocessed|APF-G1
1546230|IGL00708|7|105388260|R->Q||1.0|Probably damaging|0.06|tolerated|MGI:1921599|Fam160a2|family with sequence similarity 160, member A2 [Source:MGI Symbol;Acc:MGI:1921599]|Heterozygous||C|T|16|40.5|Non-synonymous|Unprocessed|APF-G1
1546231|IGL00708|8|84251648|I->N||1.0|Probably damaging||deleterious|MGI:1915123|Mri1|methylthioribose-1-phosphate isomerase homolog (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1915123]|Heterozygous||A|T|16|35.0|Non-synonymous|Unprocessed|APF-G1
1546726|IGL00709|18|41912423|N->Y||1.0|Probably damaging|0.06|tolerated|MGI:1924869|Prelid2|PRELI domain containing 2 [Source:MGI Symbol;Acc:MGI:1924869]|Heterozygous||T|A|92|39.0|Non-synonymous|Unprocessed|APF-G1
1546727|IGL00709|11|53669642|L->S||0.18|Benign|0.02|deleterious|MGI:109292|Rad50|RAD50 homolog (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:109292]|Heterozygous|Homozygotes for a targeted hypomorphic mutation exhibit growth defects, predisposition toward cancer, progressive loss of hematopoietic and spermatogenic stem cells, and lethality due to bone marrow depletion. A null mutation results in embryonic death.|A|G|59|40.0|Non-synonymous|Unprocessed|APF-G1
1546728|IGL00709|2|104114080|N->S|||Benign|0.03|deleterious|MGI:109177|Cd59a|CD59a antigen [Source:MGI Symbol;Acc:MGI:109177]|Heterozygous|Inactivation of this gene has been shown to result in an increased susceptibility of erythrocytes to complement lysis in vitro, however spontaneous hemolysis has only been observed in vivo in one of the two null mice lines.|A|G|56|40.0|Non-synonymous|Unprocessed|APF-G1
1546729|IGL00709|11|105798795|Y->C||0.98|Probably damaging|0.04|deleterious|MGI:2444121|Tanc2|tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 [Source:MGI Symbol;Acc:MGI:2444121]|Heterozygous|Mice homozygous for a gene trap vector die prior to E12.|A|G|51|38.0|Non-synonymous|Unprocessed|APF-G1
1546730|IGL00709|10|62598402|E->Stop|||N/A|||MGI:1860494|Ddx21|DEAD (Asp-Glu-Ala-Asp) box polypeptide 21 [Source:MGI Symbol;Acc:MGI:1860494]|Heterozygous||C|A|39|39.0|Non-synonymous|Unprocessed|APF-G1
1546731|IGL00709|12|78849754|H->R|||Benign|0.58|tolerated|MGI:1921084|Atp6v1d|ATPase, H+ transporting, lysosomal V1 subunit D [Source:MGI Symbol;Acc:MGI:1921084]|Heterozygous||T|C|32|40.0|Non-synonymous|Unprocessed|APF-G1
1546732|IGL00709|7|30242061|L->P||0.88|Possibly damaging|0.06|tolerated|MGI:1923696|Wdr62|WD repeat domain 62 [Source:MGI Symbol;Acc:MGI:1923696]|Heterozygous||A|G|22|38.5|Non-synonymous|Unprocessed|APF-G1
1546733|IGL00709|11|70613019|I->N||0.62|Possibly damaging||deleterious|MGI:1355329|Mink1|misshapen-like kinase 1 (zebrafish) [Source:MGI Symbol;Acc:MGI:1355329]|Heterozygous||T|A|19|37.0|Non-synonymous|Unprocessed|APF-G1
1546734|IGL00709|16|62822580|N->S||0.1|Benign|0.61|tolerated|MGI:1915409, MGI:1915396|Stx19,arl13b|ADP-ribosylation factor-like 13B [Source:MGI Symbol;Acc:MGI:1915396],syntaxin 19 [Source:MGI Symbol;Acc:MGI:1915409]|Heterozygous|NO_PHENOTYPE,Mice homozygous for an ENU-induced mutation die at E13-E14 exhibiting left-right randomization and absence of the floor plate in the caudal spinal cord.|A|G|18|39.0|Non-synonymous|Unprocessed|APF-G1
1546735|IGL00709|3|109159354|K->E||0.67|Possibly damaging|0.1|tolerated|MGI:1917160|Slc25a24|solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 24 [Source:MGI Symbol;Acc:MGI:1917160]|Heterozygous||A|G|17|40.0|Non-synonymous|Unprocessed|APF-G1
1546736|IGL00709|4|108590778|Disrupted splicing|||N/A|||MGI:1328337|Orc1|origin recognition complex, subunit 1 [Source:MGI Symbol;Acc:MGI:1328337]|Heterozygous||G|T|80|40.5|Splice|Unprocessed|APF-G1
1546737|IGL00709|16|44262011|Disrupted splicing|||N/A|||MGI:2443155|Sidt1|SID1 transmembrane family, member 1 [Source:MGI Symbol;Acc:MGI:2443155]|Heterozygous||C|T|16|40.5|Splice|Unprocessed|APF-G1
1547227|IGL00710|15|53344873|D->G||1.0|Probably damaging|0.19|tolerated|MGI:894663|Ext1|exostoses (multiple) 1 [Source:MGI Symbol;Acc:MGI:894663]|Heterozygous|Mice homozygous for disruptions in this gene display a lethal phenotype.|T|C|77|39.0|Non-synonymous|Unprocessed|APF-G1
1547228|IGL00710|5|86906589|Y->C||0.97|Probably damaging|0.08|tolerated|MGI:2140962|Ugt2b34|UDP glucuronosyltransferase 2 family, polypeptide B34 [Source:MGI Symbol;Acc:MGI:2140962]|Heterozygous||T|C|48|40.0|Non-synonymous|Unprocessed|APF-G1
1547229|IGL00710|17|74609089|T->A||0.97|Probably damaging|0.02|deleterious|MGI:1276108|Birc6|baculoviral IAP repeat-containing 6 [Source:MGI Symbol;Acc:MGI:1276108]|Heterozygous|Homozygous mice exhibit perinatal lethality and exhibit placental defects.|A|G|33|39.0|Non-synonymous|Unprocessed|APF-G1
1547230|IGL00710|2|124662288|K->R|||Benign|0.59|tolerated|MGI:2387661|Sema6d|sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D [Source:MGI Symbol;Acc:MGI:2387661]|Heterozygous||A|G|33|40.0|Non-synonymous|Unprocessed|APF-G1
1547231|IGL00710|9|59875311|Y->C||0.98|Probably damaging|0.13|tolerated|MGI:107735|Myo9a|myosin IXa [Source:MGI Symbol;Acc:MGI:107735]|Heterozygous||A|G|29|39.0|Non-synonymous|Unprocessed|APF-G1
1547232|IGL00710|6|124732356|D->E||0.02|Benign|0.02|deleterious|MGI:96055|Ptpn6|protein tyrosine phosphatase, non-receptor type 6 [Source:MGI Symbol;Acc:MGI:96055]|Heterozygous|Homozygous mutants are immunodeficient and autoimmune and exhibit neutrophilic skin lesions that disrupt hair follicles and give the motheaten appearance. Alleles vary in severity, with death occurring at 6-9 weeks postnatally due to severe pneumonitis.|A|T|19|37.0|Non-synonymous|Unprocessed|APF-G1
1547233|IGL00710|7|80893663|I->S|||Benign|0.65|tolerated|MGI:1919218|Wdr73|WD repeat domain 73 [Source:MGI Symbol;Acc:MGI:1919218]|Heterozygous||A|C|17|39.0|Non-synonymous|Unprocessed|APF-G1
1547741|IGL00711|9|70015376|N->I|||Benign|0.41|tolerated|MGI:1933289|Gtf2a2|general transcription factor II A, 2 [Source:MGI Symbol;Acc:MGI:1933289]|Heterozygous||A|T|78|39.0|Non-synonymous|Unprocessed|APF-G1
1547742|IGL00711|3|116793627|Y->C||1.0|Probably damaging||deleterious|MGI:1924809|Agl|amylo-1,6-glucosidase, 4-alpha-glucanotransferase [Source:MGI Symbol;Acc:MGI:1924809]|Heterozygous||T|C|71|39.0|Non-synonymous|Unprocessed|APF-G1
1547743|IGL00711|3|107104753|S->P|||Benign|0.36|tolerated|MGI:96659|Kcna2|potassium voltage-gated channel, shaker-related subfamily, member 2 [Source:MGI Symbol;Acc:MGI:96659]|Heterozygous|Mice homozygous for a null allele exhibit postnatal lethality, increased susceptibility to spontaneous and chemically-induced seizures and altered neuron electrophysiology. Mice homozygous for an ENU-induced allele exhibit abnormal gait, impaired coordination, and premature lethality.|T|C|45|39.0|Non-synonymous|Unprocessed|APF-G1
1547744|IGL00711|1|45823381|L->F|||Benign|0.48|tolerated|MGI:1920924|Wdr75|WD repeat domain 75 [Source:MGI Symbol;Acc:MGI:1920924]|Heterozygous||C|T|42|40.0|Non-synonymous|Unprocessed|APF-G1
1547745|IGL00711|1|74572434|Q->R||0.5|Possibly damaging|0.08|tolerated|MGI:1924514|Zfp142|zinc finger protein 142 [Source:MGI Symbol;Acc:MGI:1924514]|Heterozygous||T|C|24|35.0|Non-synonymous|Unprocessed|APF-G1
1547746|IGL00711|2|52111070|L->P||0.72|Possibly damaging|0.29|tolerated|MGI:1098622|Rif1|Rap1 interacting factor 1 homolog (yeast) [Source:MGI Symbol;Acc:MGI:1098622]|Heterozygous|Mice homozygous for a knock-out allele exhibit embryonic lethality.  Mice homozygous for a gene trap allele exhibit embryonic and postnatal lethality, reduced fertility, and decreased cell proliferation.|T|C|22|39.5|Non-synonymous|Unprocessed|APF-G1
1547747|IGL00711|11|116074403|M->R||0.96|Probably damaging||deleterious|MGI:1917700|Unc13d|unc-13 homolog D (C. elegans) [Source:MGI Symbol;Acc:MGI:1917700]|Heterozygous|Homozygous ENU mutant mice are sensitive to infection by mouse cytomegalovirus.|A|C|21|40.0|Non-synonymous|Unprocessed|APF-G1
1547748|IGL00711|9|118514271|Disrupted splicing|||N/A|||MGI:1859646|Golga4|golgi autoantigen, golgin subfamily a, 4 [Source:MGI Symbol;Acc:MGI:1859646]|Heterozygous||T|C|19|40.0|Splice|Unprocessed|APF-G1
1548250|IGL00712|7|107197241|N->D||1.0|Probably damaging||deleterious|MGI:1924108|Nlrp14|NLR family, pyrin domain containing 14 [Source:MGI Symbol;Acc:MGI:1924108]|Heterozygous||A|G|59|41.0|Non-synonymous|Unprocessed|APF-G1
1548251|IGL00712|11|69839237|L->S||0.87|Possibly damaging|0.05|deleterious|MGI:1916436|1810027o10rik|RIKEN cDNA 1810027O10 gene [Source:MGI Symbol;Acc:MGI:1916436]|Heterozygous||T|C|35|40.0|Non-synonymous|Unprocessed|APF-G1
1548252|IGL00712|15|8369474|R->S||0.92|Possibly damaging|0.53|tolerated|MGI:1913976|Nipbl|Nipped-B homolog (Drosophila) [Source:MGI Symbol;Acc:MGI:1913976]|Heterozygous|Mice heterozygous for a gene trap allele exhibit increased mortality from birth to early adulthood, decreased weight, decreased adipose tissue, delayed ossification, craniofacial abnormalities, and abnormal hearing, behavior, and eye morphology.|T|A|31|40.0|Non-synonymous|Unprocessed|APF-G1
1548253|IGL00712|19|9984799|T->A||0.01|Benign|0.07|tolerated|MGI:95588|Fth1|ferritin heavy chain 1 [Source:MGI Symbol;Acc:MGI:95588]|Heterozygous|Mice homozygous for disruptions in this gene die as embryos. Mice heterozygous for a knock-out allele exhibit oxidative stress in neurons.|A|G|20|39.0|Non-synonymous|Unprocessed|APF-G1
1548254|IGL00712|10|4357164|V->M||0.98|Probably damaging|0.17|tolerated|MGI:1932576|Akap12|A kinase (PRKA) anchor protein (gravin) 12 [Source:MGI Symbol;Acc:MGI:1932576]|Heterozygous|Mice homozygous for a gene trap allele that disrupts the widely expressed isoform, but not the testis-specific isoform exhibit no obvious mutant phenotype.|C|T|18|38.5|Non-synonymous|Unprocessed|APF-G1
1548255|IGL00712|6|146232436|D->G||0.61|Possibly damaging|0.29|tolerated|MGI:99418|Itpr2|inositol 1,4,5-triphosphate receptor 2 [Source:MGI Symbol;Acc:MGI:99418]|Heterozygous|Mice homozygous for a knock-out allele are viable and fertile with no apparent abnormalities in pancreatic and salivary secretion. Mice homozygous for a different knock-out allele have atrial myocytes that are significantly less prone to develop proarrhythmic disturbances in calcium signaling.|T|C|16|37.0|Non-synonymous|Unprocessed|APF-G1
1548256|IGL00712|1|54272550|Disrupted splicing|||N/A|||MGI:1925266|Ccdc150|coiled-coil domain containing 150 [Source:MGI Symbol;Acc:MGI:1925266]|Heterozygous||A|C|24|39.0|Splice|Unprocessed|APF-G1
1548257|IGL00712|12|13362625|Disrupted splicing|||N/A|||MGI:1918419|Nbas|neuroblastoma amplified sequence [Source:MGI Symbol;Acc:MGI:1918419]|Heterozygous||A|G|17|38.0|Splice|Unprocessed|APF-G1
1548681|IGL00713|5|86667505|S->G||0.95|Possibly damaging|0.08|tolerated|MGI:2442893|Tmprss11bnl|transmembrane protease, serine 11b N terminal like [Source:MGI Symbol;Acc:MGI:2442893]|Heterozygous||T|C|148|41.0|Non-synonymous|Unprocessed|APF-G1
1548682|IGL00713|2|120924175|N->K||0.84|Possibly damaging|0.16|tolerated|MGI:1277977|Ubr1|ubiquitin protein ligase E3 component n-recognin 1 [Source:MGI Symbol;Acc:MGI:1277977]|Heterozygous|Homozygous null mutants have 20% lower body weight and reduced muscle and adipose tissue. Skeletal muscle lacks a mechanism for targeting proteins for rapid catabolism. Aberrant regulation of fatty acid synthase upon starvation is also observed.|A|T|143|39.0|Non-synonymous|Unprocessed|APF-G1
1548683|IGL00713|6|67452474|S->P||0.98|Probably damaging|0.02|deleterious|MGI:2181693|Il23r|interleukin 23 receptor [Source:MGI Symbol;Acc:MGI:2181693]|Heterozygous|Th17 T cells from homozygous null mice have less secretion of IL-9 upon secondary stimulation.|A|G|62|39.0|Non-synonymous|Unprocessed|APF-G1
1548684|IGL00713|10|7799649|D->E|||Benign|0.92|tolerated|MGI:1914668|Ppil4|peptidylprolyl isomerase (cyclophilin)-like 4 [Source:MGI Symbol;Acc:MGI:1914668]|Heterozygous||T|A|45|41.0|Non-synonymous|Unprocessed|APF-G1
1548685|IGL00713|16|59915840|I->T||0.27|Benign|0.08|tolerated|MGI:108034|Epha6|Eph receptor A6 [Source:MGI Symbol;Acc:MGI:108034]|Heterozygous|Mice homozygous for a knock-out allele display discrete learning and memory deficits.|A|G|35|39.0|Non-synonymous|Unprocessed|APF-G1
1548686|IGL00713|4|148537422|I->V||0.59|Possibly damaging|0.04|deleterious|MGI:1928394|Mtor|mechanistic target of rapamycin (serine/threonine kinase) [Source:MGI Symbol;Acc:MGI:1928394]|Heterozygous|Mice homozygous for a null allele exhibit embryonic lethality by E12.5 due to abnormal embryogenesis.  Mice homozygous for an ENU mutation exhibit embryonic lethality by E12.5 with abnormal embryogenesis and brain development.  Mice homozygous for a gene trap allele exhibit abnormal embryogenesis.|A|G|27|40.0|Non-synonymous|Unprocessed|APF-G1
1548687|IGL00713|5|92245501|V->M||1.0|Probably damaging||deleterious|MGI:1342304|Ppef2|protein phosphatase, EF hand calcium-binding domain 2 [Source:MGI Symbol;Acc:MGI:1342304]|Heterozygous|Homozygotes for a targeted null mutation appear to be phenotypically normal.|C|T|26|39.5|Non-synonymous|Unprocessed|APF-G1
1548688|IGL00713|6|23002158|S->P||0.64|Possibly damaging||deleterious|MGI:97816|Ptprz1|protein tyrosine phosphatase, receptor type Z, polypeptide 1 [Source:MGI Symbol;Acc:MGI:97816]|Heterozygous|Mice homozygous for targeted null mutations demonstrate an impaired ability to recover from inflamatory lesions of the CNS or gastric mucosa.  Mice homozygous for a knock-out allele exhibit increased tactile and thermal nociception thresholds.|T|C|26|40.0|Non-synonymous|Unprocessed|APF-G1
1548689|IGL00713|17|43617217|V->E||0.8|Possibly damaging|0.05|tolerated|MGI:2679727|Tdrd6|tudor domain containing 6 [Source:MGI Symbol;Acc:MGI:2679727]|Heterozygous||A|T|24|38.5|Non-synonymous|Unprocessed|APF-G1
1548690|IGL00713|6|36920422|D->G||0.02|Benign|0.07|tolerated|MGI:2443430|Dgki|diacylglycerol kinase, iota [Source:MGI Symbol;Acc:MGI:2443430]|Heterozygous|Mice homozygous for a knock-out allele are grossly normal and do not develop tumors when wounded or when exposed to phorbol ester.|T|C|18|37.0|Non-synonymous|Unprocessed|APF-G1
1548691|IGL00713|5|90801244|Disrupted splicing|||N/A|||MGI:1339941|Cxcl15|chemokine (C-X-C motif) ligand 15 [Source:MGI Symbol;Acc:MGI:1339941]|Heterozygous|Mice homozygous for a targeted null mutation are viable and fertile but display reduced host defense against the pulmonary pathogen <I>Klebsiella pneumoniae</I>.|T|A|37|39.0|Splice|Unprocessed|APF-G1
1549140|IGL00714|2|144559225|A->V||0.22|Benign|0.06|tolerated|MGI:1350925|Sec23b|SEC23B (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1350925]|Heterozygous||C|T|73|39.0|Non-synonymous|Unprocessed|APF-G1
1549141|IGL00714|4|32649192|Q->R||0.72|Possibly damaging||deleterious|MGI:1349399|Casp8ap2|caspase 8 associated protein 2 [Source:MGI Symbol;Acc:MGI:1349399]|Heterozygous||A|G|37|40.0|Non-synonymous|Unprocessed|APF-G1
1549142|IGL00714|17|21026702|T->S|||Benign|0.12|tolerated|MGI:108187|Zfp160|zinc finger protein 160 [Source:MGI Symbol;Acc:MGI:108187]|Heterozygous||A|T|30|40.0|Non-synonymous|Unprocessed|APF-G1
1549143|IGL00714|16|36124999|V->A||1.0|Probably damaging||deleterious|MGI:3524930|Csta|cystatin A [Source:MGI Symbol;Acc:MGI:3524930]|Heterozygous||A|G|21|39.0|Non-synonymous|Unprocessed|APF-G1
1549144|IGL00714|7|30876147|M->V|||Benign|0.18|tolerated|MGI:88322|Cd22|CD22 antigen [Source:MGI Symbol;Acc:MGI:88322]|Heterozygous|Homozygous null mice have reduced mature B cell numbers with altered proliferation kinetics and reduced antibody production to T cell independent antigens.|T|C|19|39.0|Non-synonymous|Unprocessed|APF-G1
1549145|IGL00714|4|46649745|V->A||0.02|Benign|0.25|tolerated|MGI:2652885|Tbc1d2|TBC1 domain family, member 2 [Source:MGI Symbol;Acc:MGI:2652885]|Heterozygous||A|G|18|38.0|Non-synonymous|Unprocessed|APF-G1
1549146|IGL00714|2|152984260|E->A||1.0|Probably damaging|0.01|deleterious|MGI:1913589|Ttll9|tubulin tyrosine ligase-like family, member 9 [Source:MGI Symbol;Acc:MGI:1913589]|Heterozygous||A|C|17|40.0|Non-synonymous|Unprocessed|APF-G1
1549147|IGL00714|18|36932175|T->S|||N/A||deleterious|MGI:2150982|Pcdha1|protocadherin alpha 1 [Source:MGI Symbol;Acc:MGI:2150982]|Heterozygous|Mice homozygous for a null allele are viable and fertile.|A|T|16|36.0|Non-synonymous|Unprocessed|APF-G1
1549148|IGL00714|18|38198729|T->I||0.04|Benign|0.19|tolerated|MGI:104692|Pcdh1|protocadherin 1 [Source:MGI Symbol;Acc:MGI:104692]|Heterozygous||G|A|16|40.0|Non-synonymous|Unprocessed|APF-G1
1549149|IGL00714|7|12556004|Disrupted splicing|||N/A|||MGI:1920340|2900092c05rik|RIKEN cDNA 2900092C05 gene [Source:MGI Symbol;Acc:MGI:1920340]|Heterozygous||A|C|41|40.0|Splice|Unprocessed|APF-G1
1549150|IGL00714|3|34047627|Disrupted splicing|||N/A|||MGI:104860|Fxr1|fragile X mental retardation gene 1, autosomal homolog [Source:MGI Symbol;Acc:MGI:104860]|Heterozygous|Homozygous null mice display neonatal lethality with impaired muscle development. Mice homozygous for a hypomorphic allele display a reduced life span with impaired muscle development, growth retardation, and reduced grip strength.|T|C|40|39.5|Splice|Unprocessed|APF-G1
1549620|IGL00715|4|98934581|S->P|||Benign|0.28|tolerated|MGI:2385198|Usp1|ubiquitin specific peptidase 1 [Source:MGI Symbol;Acc:MGI:2385198]|Heterozygous|Homozygous null mice have a high rate of postnatal lethality related to cyanosis.  Male survivors are infertile while female survivors have reduced fertility.  Both sexes have reduced number of gametes, are sensitive to ionizing radiation, and have decreased numbers of bone marrow cells.|T|C|71|40.0|Non-synonymous|Unprocessed|APF-G1
1549621|IGL00715|1|125395076|A->T||0.05|Benign|0.04|deleterious|MGI:1921367|Actr3|ARP3 actin-related protein 3 homolog (yeast) [Source:MGI Symbol;Acc:MGI:1921367]|Heterozygous|Mice homozygous for a null allele die prior to E4.5 and exhibit abnormal embryogenesis.|C|T|67|40.0|Non-synonymous|Unprocessed|APF-G1
1549622|IGL00715|12|72652390|M->L||0.01|Benign|0.43|tolerated|MGI:1913625|Dhrs7|dehydrogenase/reductase (SDR family) member 7 [Source:MGI Symbol;Acc:MGI:1913625]|Heterozygous||T|A|65|36.0|Non-synonymous|Unprocessed|APF-G1
1549623|IGL00715|X|21084254|D->G||1.0|Probably damaging|0.02|deleterious|MGI:3045326|Zfp300|zinc finger protein 300 [Source:MGI Symbol;Acc:MGI:3045326]|Heterozygous||T|C|57|40.0|Non-synonymous|Unprocessed|APF-G1
1549624|IGL00715|3|72934124|I->T||0.95|Probably damaging||deleterious|MGI:97528|Sis|sucrase isomaltase (alpha-glucosidase) [Source:MGI Symbol;Acc:MGI:1917233]|Heterozygous||A|G|54|40.0|Non-synonymous|Unprocessed|APF-G1
1549625|IGL00715|1|162888713|K->Stop|||N/A|||MGI:1916776|Fmo2|flavin containing monooxygenase 2 [Source:MGI Symbol;Acc:MGI:1916776]|Heterozygous||T|A|52|40.0|Non-synonymous|Unprocessed|APF-G1
1549626|IGL00715|X|107102583|S->R||1.0|Probably damaging|0.17|tolerated|MGI:1926076|P2ry10|purinergic receptor P2Y, G-protein coupled 10 [Source:MGI Symbol;Acc:MGI:1926076]|Heterozygous||T|A|50|37.5|Non-synonymous|Unprocessed|APF-G1
1549627|IGL00715|13|33931512|F->S||0.66|Possibly damaging|0.11|tolerated|MGI:103123|Serpinb6a|serine (or cysteine) peptidase inhibitor, clade B, member 6a [Source:MGI Symbol;Acc:MGI:103123]|Heterozygous|Mice homozygous for a reporter allele are viable, fertile and developmentally normal, with no apparent alterations in growth, leukocyte function, or sensitivity to cerebral ischemia.|A|G|46|40.0|Non-synonymous|Unprocessed|APF-G1
1549628|IGL00715|9|92598614|R->H||1.0|Probably damaging|0.01|deleterious|MGI:1347007|Plod2|procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 [Source:MGI Symbol;Acc:MGI:1347007]|Heterozygous||G|A|43|40.0|Non-synonymous|Unprocessed|APF-G1
1549629|IGL00715|18|36785936|C->Y||0.15|Benign|0.02|deleterious|MGI:1918041|Hars2|histidyl-tRNA synthetase 2, mitochondrial (putative) [Source:MGI Symbol;Acc:MGI:1918041]|Heterozygous||G|A|41|39.0|Non-synonymous|Unprocessed|APF-G1
1549630|IGL00715|11|70639918|N->T||0.02|Benign|0.1|tolerated|MGI:1333744|Gp1ba|glycoprotein 1b, alpha polypeptide [Source:MGI Symbol;Acc:MGI:1333744]|Heterozygous|Homozygotes for a targeted null mutation exhibit prolonged bleeding times and reduced numbers of enlarged platelets. Heterozygotes have intermediate numbers of platelets.|A|C|34|38.5|Non-synonymous|Unprocessed|APF-G1
1549631|IGL00715|3|104463948|V->A||1.0|Probably damaging||deleterious|MGI:2443718|Lrig2|leucine-rich repeats and immunoglobulin-like domains 2 [Source:MGI Symbol;Acc:MGI:2443718]|Heterozygous||A|G|34|39.0|Non-synonymous|Unprocessed|APF-G1
1549632|IGL00715|X|139334234|D->G|||Unknown|||MGI:98818|Trap1a|tumor rejection antigen P1A [Source:MGI Symbol;Acc:MGI:98818]|Heterozygous|Tumor rejection antigens to mouse mastocytoma P815 were identified and transfectants expressing tumor rejection antigens in vitro obtained. The gene coding for the antigens is identical with the gene present in normal cells. This gene, Trap1a, has little/no expression in non-tumor cells.|A|G|31|38.0|Non-synonymous|Unprocessed|APF-G1
1549633|IGL00715|7|45830613|Y->H||1.0|Probably damaging|0.13|tolerated|MGI:2141989|Grwd1|glutamate-rich WD repeat containing 1 [Source:MGI Symbol;Acc:MGI:2141989]|Heterozygous||A|G|25|35.0|Non-synonymous|Unprocessed|APF-G1
1549634|IGL00715|14|30596003|N->S||1.0|Probably damaging|0.01|deleterious|MGI:97598|Prkcd|protein kinase C, delta [Source:MGI Symbol;Acc:MGI:97598]|Heterozygous|Mice homozygous for a null allele exhibit decreased neutrophil cell numbers and activity, increased B cell numbers and proliferation, increased acute inflammation, and increased IgG1 and IgA serum levels.|T|C|24|39.0|Non-synonymous|Unprocessed|APF-G1
1549635|IGL00715|7|123250174|A->V||0.86|Possibly damaging|0.02|deleterious|MGI:1919316|Slc5a11|solute carrier family 5 (sodium/glucose cotransporter), member 11 [Source:MGI Symbol;Acc:MGI:1919316]|Heterozygous||C|T|22|41.0|Non-synonymous|Unprocessed|APF-G1
1549636|IGL00715|12|99196607|E->G||1.0|Probably damaging|0.3|tolerated|MGI:1918625|Foxn3|forkhead box N3 [Source:MGI Symbol;Acc:MGI:1918625]|Heterozygous||T|C|20|37.5|Non-synonymous|Unprocessed|APF-G1
1549637|IGL00715|17|27083629|V->A|||Benign|0.58|tolerated|MGI:96624|Itpr3|inositol 1,4,5-triphosphate receptor 3 [Source:MGI Symbol;Acc:MGI:96624]|Heterozygous|Mice homozygous for a knock-out allele are viable and fertile and exhibit no apparent abnormalities in pancreatic and salivary secretion.|T|C|20|37.5|Non-synonymous|Unprocessed|APF-G1
1549638|IGL00715|7|35794712|E->G||0.81|Possibly damaging|0.05|tolerated|MGI:1916378|Zfp507|zinc finger protein 507 [Source:MGI Symbol;Acc:MGI:1916378]|Heterozygous||T|C|20|39.0|Non-synonymous|Unprocessed|APF-G1
1549639|IGL00715|2|118713734|Disrupted splicing|||N/A|||MGI:107465|Plcb2|phospholipase C, beta 2 [Source:MGI Symbol;Acc:MGI:107465]|Heterozygous|Homozygous mutant mice showed an increased sensitivity to both bacterial and viral infections and exhibited abnormal taste perception in which sweet, umami, and bitter stimuli could not be sensed.|C|T|43|39.0|Splice|Unprocessed|APF-G1
1549640|IGL00715|11|101183205|Disrupted splicing|||N/A|||MGI:1858201|Cntnap1|contactin associated protein-like 1 [Source:MGI Symbol;Acc:MGI:1858201]|Heterozygous|Homozygous mutant mice exhibit reduced body size and nervous system defects, including impaired balance, hypoactivity, and and ataxia.|C|T|41|36.0|Splice|Unprocessed|APF-G1
1549641|IGL00715|4|11797780|Disrupted splicing|||N/A|||MGI:1095414|Cdh17|cadherin 17 [Source:MGI Symbol;Acc:MGI:1095414]|Heterozygous|Homozygous mutant mice exhibit impaired B lymphocyte development and impaired IgG1 and IgG3 antibody response to T-independent antigen.|A|T|39|40.0|Splice|Unprocessed|APF-G1
1549642|IGL00715|6|106712474|Disrupted splicing|||N/A|||MGI:96558|Il5ra|interleukin 5 receptor, alpha [Source:MGI Symbol;Acc:MGI:96558]|Heterozygous|Mice homozygous for disruptions in this gene display a generally normal phenotype but with some immune system deficiencies.|C|T|38|40.5|Splice|Unprocessed|APF-G1
1549643|IGL00715|2|172989032|Disrupted splicing|||N/A|||MGI:1349669|Spo11|sporulation protein, meiosis-specific, SPO11 homolog (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1349669]|Heterozygous|Homozygotes for a targeted null mutation are sterile. Mutant males exhibit loss of spermatocytes in early prophase, while mutant females exhibit oocyte loss soon after birth.|T|C|23|39.0|Splice|Unprocessed|APF-G1
1549644|IGL00715|5|70815955|Disrupted splicing|||N/A|||MGI:103156|Gabrg1|gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 [Source:MGI Symbol;Acc:MGI:103156]|Heterozygous||A|G|23|40.0|Splice|Unprocessed|APF-G1
1549645|IGL00715|16|90753321|Disrupted splicing|||N/A|||MGI:2146468|Urb1|URB1 ribosome biogenesis 1 homolog (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:2146468]|Heterozygous||A|G|17|39.0|Splice|Unprocessed|APF-G1
1550643|IGL00717|14|56465750|T->A||0.05|Benign|0.44|tolerated|MGI:1353419|Rnf17|ring finger protein 17 [Source:MGI Symbol;Acc:MGI:1353419]|Heterozygous|Homozygous null mice display male infertility, azoospermia, arrest of spermatogenesis, and small testis.|A|G|90|39.5|Non-synonymous|Unprocessed|APF-G1
1550644|IGL00717|18|60246293|E->G||0.98|Probably damaging|0.01|deleterious|MGI:3644953|Gm4951|predicted gene 4951 [Source:MGI Symbol;Acc:MGI:3644953]|Heterozygous||A|G|88|40.0|Non-synonymous|Unprocessed|APF-G1
1550645|IGL00717|3|116114471|K->N||1.0|Probably damaging|0.55|tolerated|MGI:98926|Vcam1|vascular cell adhesion molecule 1 [Source:MGI Symbol;Acc:MGI:98926]|Heterozygous|Most homozygous null mutants die by embryonic day 12.5 due to defective placenta and failure of chorion/allantois fusion, and heart developmental anomalies. Survivors are generally normal, but have high numbers of circulating blood mononuclear leukocytes.|C|A|84|39.0|Non-synonymous|Unprocessed|APF-G1
1550646|IGL00717|15|79596280|M->T||0.01|Benign|0.1|tolerated|MGI:105393|Dmc1|DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast) [Source:MGI Symbol;Acc:MGI:105393]|Heterozygous|Homozygotes for targeted mutations are sterile with failure of homologous pairing in meiotic prophase in males and disrupted oogenesis in embryonic females with absence of germ cells in the adult ovary.|A|G|38|40.0|Non-synonymous|Unprocessed|APF-G1
1550647|IGL00717|7|79412700|L->F||0.99|Probably damaging|0.03|deleterious|MGI:2384790|Fanci|Fanconi anemia, complementation group I [Source:MGI Symbol;Acc:MGI:2384790]|Heterozygous||C|T|38|40.0|Non-synonymous|Unprocessed|APF-G1
1550648|IGL00717|1|83198179|I->F||0.01|Benign|0.05|deleterious|MGI:1923089|Wdr69|WD repeat domain 69 [Source:MGI Symbol;Acc:MGI:1923089]|Heterozygous||A|T|34|40.0|Non-synonymous|Unprocessed|APF-G1
1550649|IGL00717|9|5352702|T->A||0.34|Benign|0.01|deleterious|MGI:1312922|Casp12|caspase 12 [Source:MGI Symbol;Acc:MGI:1312922]|Heterozygous|Homozygous mice for some mutations of this gene display resistance to ER stress-induced apoptosis.|A|G|34|39.0|Non-synonymous|Unprocessed|APF-G1
1550650|IGL00717|12|98276055|I->M|||Benign|0.2|tolerated|MGI:108031|Gpr65|G-protein coupled receptor 65 [Source:MGI Symbol;Acc:MGI:108031]|Heterozygous|Homozygous mutant mice have thymocytes and splenocytes that are insensitive to pH-dependent cAMP production.|A|G|32|39.0|Non-synonymous|Unprocessed|APF-G1
1550651|IGL00717|7|143073990|V->E||0.1|Benign|0.04|deleterious|MGI:1861718|Trpm5|transient receptor potential cation channel, subfamily M, member 5 [Source:MGI Symbol;Acc:MGI:1861718]|Heterozygous|Homozygous mutant mice demonstrate abnormal taste perception, responding to sour and salty stimuli but not to sweet, or bitter stimuli.|A|T|24|33.0|Non-synonymous|Unprocessed|APF-G1
1550652|IGL00717|9|66485002|D->G||1.0|Probably damaging|0.03|deleterious|MGI:2384589|Herc1|hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1 [Source:MGI Symbol;Acc:MGI:2384589]|Heterozygous|Homozygotes for this spontaneous mutation exhibit an abnormal cerebellar Purkinje cell layer and Purkinje cell degeneration.|A|G|22|37.0|Non-synonymous|Unprocessed|APF-G1
1550653|IGL00717|19|8609929|I->K||0.01|Benign|0.06|tolerated|MGI:1336187|Slc22a8|solute carrier family 22 (organic anion transporter), member 8 [Source:MGI Symbol;Acc:MGI:1336187]|Heterozygous|Mice homozygous for a null allele exhibit decreased urinary urate levels.|T|A|17|37.0|Non-synonymous|Unprocessed|APF-G1
1550654|IGL00717|2|104430231|T->K||0.18|Benign|0.08|tolerated|MGI:1314882|Hipk3|homeodomain interacting protein kinase 3 [Source:MGI Symbol;Acc:MGI:1314882]|Heterozygous||G|T|17|40.0|Non-synonymous|Unprocessed|APF-G1
1550655|IGL00717|12|59160273|Disrupted splicing|||N/A|||MGI:1346056|Ctage5|CTAGE family, member 5 [Source:MGI Symbol;Acc:MGI:1346056]|Heterozygous||A|G|35|39.0|Splice|Unprocessed|APF-G1
1551164|IGL00718|3|123371339|I->M||0.96|Probably damaging|0.09|tolerated|MGI:2442926|Mettl14|methyltransferase like 14 [Source:MGI Symbol;Acc:MGI:2442926]|Heterozygous||T|C|208|41.0|Non-synonymous|Unprocessed|APF-G1
1551165|IGL00718|4|15933056|D->Y||0.08|Benign|0.05|tolerated|MGI:1914710|Decr1|2,4-dienoyl CoA reductase 1, mitochondrial [Source:MGI Symbol;Acc:MGI:1914710]|Heterozygous|Mice homozygous for a null allele exhibit increased sensitivity to fasting and cold stresses.|C|A|99|40.0|Non-synonymous|Unprocessed|APF-G1
1551166|IGL00718|19|11557971|N->I||0.98|Probably damaging||deleterious|MGI:1913857|Ms4a4d|membrane-spanning 4-domains, subfamily A, member 4D [Source:MGI Symbol;Acc:MGI:1913857]|Heterozygous||A|T|87|40.0|Non-synonymous|Unprocessed|APF-G1
1551167|IGL00718|18|37444821|Y->H||1.0|Probably damaging|0.03|deleterious|MGI:2136748|Pcdhb13|protocadherin beta 13 [Source:MGI Symbol;Acc:MGI:2136748]|Heterozygous||T|C|50|38.0|Non-synonymous|Unprocessed|APF-G1
1551168|IGL00718|14|65931427|T->I||1.0|Probably damaging|||MGI:2444418|Scara3|scavenger receptor class A, member 3 [Source:MGI Symbol;Acc:MGI:2444418]|Heterozygous||G|A|49|37.0|Non-synonymous|Unprocessed|APF-G1
1551169|IGL00718|8|25706534|V->A||0.56|Possibly damaging||deleterious|MGI:2142581|Whsc1l1|Wolf-Hirschhorn syndrome candidate 1-like 1 (human) [Source:MGI Symbol;Acc:MGI:2142581]|Heterozygous||T|C|49|39.0|Non-synonymous|Unprocessed|APF-G1
1551170|IGL00718|7|79444174|K->R||0.97|Probably damaging|0.26|tolerated|MGI:2384790|Fanci|Fanconi anemia, complementation group I [Source:MGI Symbol;Acc:MGI:2384790]|Heterozygous||A|G|45|40.0|Non-synonymous|Unprocessed|APF-G1
1551171|IGL00718|6|121040449|H->Q||0.51|Possibly damaging|0.3|tolerated|MGI:2442733|Mical3|microtubule associated monoxygenase, calponin and LIM domain containing 3 [Source:MGI Symbol;Acc:MGI:2442733]|Heterozygous||G|T|42|39.0|Non-synonymous|Unprocessed|APF-G1
1551172|IGL00718|4|106409704|S->P||0.6|Possibly damaging|0.02|deleterious|MGI:1919936|Usp24|ubiquitin specific peptidase 24 [Source:MGI Symbol;Acc:MGI:1919936]|Heterozygous||T|C|35|37.0|Non-synonymous|Unprocessed|APF-G1
1551173|IGL00718|8|107042626|N->S|||Benign|0.1|tolerated|MGI:1890520|Vps4a|vacuolar protein sorting 4a (yeast) [Source:MGI Symbol;Acc:MGI:1890520]|Heterozygous||A|G|35|39.0|Non-synonymous|Unprocessed|APF-G1
1551174|IGL00718|12|103169647|V->A||0.03|Benign|0.05|tolerated|MGI:2684729|Unc79|unc-79 homolog (C. elegans) [Source:MGI Symbol;Acc:MGI:2684729]|Heterozygous||T|C|30|37.0|Non-synonymous|Unprocessed|APF-G1
1551175|IGL00718|17|83448184|I->V|||Benign|1.0|tolerated|MGI:1926048|Eml4|echinoderm microtubule associated protein like 4 [Source:MGI Symbol;Acc:MGI:1926048]|Heterozygous||A|G|30|41.0|Non-synonymous|Unprocessed|APF-G1
1551176|IGL00718|9|30432326|L->Q||1.0|Probably damaging||deleterious|MGI:1921581|Snx19|sorting nexin 19 [Source:MGI Symbol;Acc:MGI:1921581]|Heterozygous||T|A|30|36.0|Non-synonymous|Unprocessed|APF-G1
1551177|IGL00718|2|25892407|T->M||1.0|Probably damaging||deleterious|MGI:1924627|Kcnt1|potassium channel, subfamily T, member 1 [Source:MGI Symbol;Acc:MGI:1924627]|Heterozygous||C|T|25|35.0|Non-synonymous|Unprocessed|APF-G1
1551178|IGL00718|4|134234701|E->G||0.1|Benign|0.28|tolerated|MGI:2670958|Cnksr1|connector enhancer of kinase suppressor of Ras 1 [Source:MGI Symbol;Acc:MGI:2670958]|Heterozygous||T|C|19|35.0|Non-synonymous|Unprocessed|APF-G1
1551179|IGL00718|9|106713455|T->A||1.0|Probably damaging||deleterious|MGI:1933196|Rad54l2|RAD54 like 2 (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1933196]|Heterozygous|Homozygous null embryos show delayed growth, reduced cell proliferation, increased apoptosis and die by E11.5. At E9.5-E10.5, most major organs are smaller and the neural tube is shrunk in some cases. Mutant MEFs cease to grow after 2-3 passages showing increased apoptosis and reduced DNA synthesis.|T|C|18|34.5|Non-synonymous|Unprocessed|APF-G1
1551180|IGL00718|4|35213015|L->H||1.0|Probably damaging||deleterious|MGI:1920455|3110043o21rik|RIKEN cDNA 3110043O21 gene [Source:MGI Symbol;Acc:MGI:1920455]|Heterozygous||A|T|16|37.0|Non-synonymous|Unprocessed|APF-G1
1551181|IGL00718|11|98249676|Disrupted splicing|||N/A|||MGI:1098802|Cdk12|cyclin-dependent kinase 12 [Source:MGI Symbol;Acc:MGI:1098802]|Heterozygous||T|C|41|39.0|Splice|Unprocessed|APF-G1
1551182|IGL00718|3|87813674|Disrupted splicing|||N/A|||MGI:1346037|Insrr|insulin receptor-related receptor [Source:MGI Symbol;Acc:MGI:1346037]|Heterozygous|Mice homozygous for a targeted null mutation exhibit no anomalies in pancreatic islet morphology, beta-cell mass or pancreatic secretory function.  This mutation in combination with Insr mutant mice does not affect the diabetes predisposition of Insr mutant mice.|G|T|34|39.0|Splice|Unprocessed|APF-G1
1551701|IGL00719|2|131305693|V->I|||Benign|0.14|tolerated|MGI:1261771|Rnf24|ring finger protein 24 [Source:MGI Symbol;Acc:MGI:1261771]|Heterozygous||C|T|146|40.0|Non-synonymous|Unprocessed|APF-G1
1551702|IGL00719|5|150722542|T->N||0.04|Benign|0.47|tolerated|MGI:2140945|Pds5b|PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:2140945]|Heterozygous|Mice homozygous for a null allele exhibit embryonic and neonatal lethality with cardiac defects, craniofacial abnormalities, axial skeletal defects, shortening of most of the long bones, abnormal enteric nervous system morphology, and decreased germ cells.|C|A|141|41.0|Non-synonymous|Unprocessed|APF-G1
1551703|IGL00719|14|103076032|T->M||0.12|Benign|0.03|deleterious|MGI:2442253|Cln5|ceroid-lipofuscinosis, neuronal 5 [Source:MGI Symbol;Acc:MGI:2442253]|Heterozygous|Homozygous mutants showed loss of vision and accumulation of autofluorescent storage material in the central nervous system.  Loss of a subset of GABAergic interneurons was seen in several brain areas.|C|T|118|41.0|Non-synonymous|Unprocessed|APF-G1
1551704|IGL00719|3|40801789|D->V||1.0|Probably damaging||deleterious|MGI:101783|Plk4|polo-like kinase 4 (Drosophila) [Source:MGI Symbol;Acc:MGI:101783]|Heterozygous|Mice homozygous for disruptions of this gene die before birth.  Development is arrested around E7.5.|A|T|57|40.0|Non-synonymous|Unprocessed|APF-G1
1551705|IGL00719|11|106235749|V->A||0.99|Probably damaging||deleterious|MGI:1919297|Ddx42|DEAD (Asp-Glu-Ala-Asp) box polypeptide 42 [Source:MGI Symbol;Acc:MGI:1919297]|Heterozygous||T|C|56|39.5|Non-synonymous|Unprocessed|APF-G1
1551706|IGL00719|11|106250179|D->G||0.89|Possibly damaging||deleterious|MGI:1860295|Ftsj3|FtsJ homolog 3 (E. coli) [Source:MGI Symbol;Acc:MGI:1860295]|Heterozygous||T|C|44|37.0|Non-synonymous|Unprocessed|APF-G1
1551707|IGL00719|17|23175742|T->A||0.47|Possibly damaging|0.14|tolerated|MGI:99185|Zfp40|zinc finger protein 40 [Source:MGI Symbol;Acc:MGI:99185]|Heterozygous||T|C|42|40.0|Non-synonymous|Unprocessed|APF-G1
1551708|IGL00719|10|41898325|T->I||0.74|Possibly damaging|0.07|tolerated|MGI:2155278|Sesn1|sestrin 1 [Source:MGI Symbol;Acc:MGI:2155278]|Heterozygous||C|T|33|39.0|Non-synonymous|Unprocessed|APF-G1
1551709|IGL00719|2|119947453|Y->Stop|||N/A|||MGI:1352483|Mga|MAX gene associated [Source:MGI Symbol;Acc:MGI:1352483]|Heterozygous||T|A|30|41.0|Non-synonymous|Unprocessed|APF-G1
1551710|IGL00719|13|32971546|T->S|||Benign||deleterious|MGI:894688|Serpinb6b|serine (or cysteine) peptidase inhibitor, clade B, member 6b [Source:MGI Symbol;Acc:MGI:894688]|Heterozygous||A|T|24|38.0|Non-synonymous|Unprocessed|APF-G1
1551711|IGL00719|18|34862494|E->K||0.67|Possibly damaging||deleterious|MGI:95295|Egr1|early growth response 1 [Source:MGI Symbol;Acc:MGI:95295]|Heterozygous|Homozygotes for targeted mutations are small and infertile due to pituitary defects. Mutants exhibit reductions in somatotropes and growth hormone content, and a lack of luteinizing hormone-beta expression. Ovaries lack luteinizing hormone receptors.  Memory defects are also seen.|G|A|23|39.0|Non-synonymous|Unprocessed|APF-G1
1551712|IGL00719|8|48279042|T->A|||N/A|0.02|deleterious|MGI:1345183|Odz3|odd Oz/ten-m homolog 3 (Drosophila) [Source:MGI Symbol;Acc:MGI:1345183]|Heterozygous|Mice homozygous for a null mutation display abnormal ipsilateral retinal ganglion cell projections and impaired performance in visually mediated behavioral tasks.|T|C|22|35.5|Non-synonymous|Unprocessed|APF-G1
1551713|IGL00719|12|28564249|E->K|||Benign|0.65|tolerated|MGI:2136971|Allc|allantoicase [Source:MGI Symbol;Acc:MGI:2136971]|Heterozygous||C|T|18|37.0|Non-synonymous|Unprocessed|APF-G1
1551714|IGL00719|5|3679087|I->N||1.0|Probably damaging||deleterious|MGI:1922305|4930511m11rik|RIKEN cDNA 4930511M11 gene [Source:MGI Symbol;Acc:MGI:1922305]|Heterozygous||T|A|18|41.0|Non-synonymous|Unprocessed|APF-G1
1551715|IGL00719|12|24939354|Disrupted splicing|||N/A|||MGI:1914466|Mboat2|membrane bound O-acyltransferase domain containing 2 [Source:MGI Symbol;Acc:MGI:1914466]|Heterozygous||T|A|27|40.0|Splice|Unprocessed|APF-G1
1551716|IGL00719|3|84969309|Disrupted splicing|||N/A|||MGI:1354695|Fbxw7|F-box and WD-40 domain protein 7 [Source:MGI Symbol;Acc:MGI:1354695]|Heterozygous|Homozygous inactivation of this locus disrupts embryonic and extraembryonic vasculature, resulting in death by midgestation.|A|G|23|37.0|Splice|Unprocessed|APF-G1
1551717|IGL00719|12|57307353|Disrupted splicing|||N/A|||MGI:1920740|Mipol1|mirror-image polydactyly gene 1 homolog (human) [Source:MGI Symbol;Acc:MGI:1920740]|Heterozygous||T|A|20|32.5|Splice|Unprocessed|APF-G1
1552218|IGL00720|2|165352605|F->I||1.0|Probably damaging||deleterious|MGI:2685854|Zfp663|zinc finger protein 663 [Source:MGI Symbol;Acc:MGI:2685854]|Heterozygous||A|T|57|39.0|Non-synonymous|Unprocessed|APF-G1
1552219|IGL00720|13|21445199|R->H|||Benign|0.14|tolerated|MGI:3531417|Zfp187|zinc finger protein 187 [Source:MGI Symbol;Acc:MGI:3531417]|Heterozygous||C|T|45|39.0|Non-synonymous|Unprocessed|APF-G1
1552220|IGL00720|8|48276421|N->D|||N/A|0.06|tolerated|MGI:1345183|Odz3|odd Oz/ten-m homolog 3 (Drosophila) [Source:MGI Symbol;Acc:MGI:1345183]|Heterozygous|Mice homozygous for a null mutation display abnormal ipsilateral retinal ganglion cell projections and impaired performance in visually mediated behavioral tasks.|T|C|33|40.0|Non-synonymous|Unprocessed|APF-G1
1552221|IGL00720|2|66676044|S->R||0.63|Possibly damaging||deleterious|MGI:102965|Scn7a|sodium channel, voltage-gated, type VII, alpha [Source:MGI Symbol;Acc:MGI:102965]|Heterozygous|Mice homozygous for disruptions in this gene have a modified dietary preference for NaCl but are phenotypically normal otherwise.|A|T|32|38.5|Non-synonymous|Unprocessed|APF-G1
1552222|IGL00720|13|54214821|V->A||0.77|Possibly damaging|0.13|tolerated|MGI:108482|Hrh2|histamine receptor H2 [Source:MGI Symbol;Acc:MGI:108482]|Heterozygous|Homozygotes for a targeted null mutation exhibit enlarged folds in gastric mucosa, elevated serum gastrin levels, increased numbers of parietal and enterochromaffin-like cells, and lack of secretion of gastric acid in response to histamine or gastrin.|T|C|26|38.0|Non-synonymous|Unprocessed|APF-G1
1552223|IGL00720|19|24921131|D->G||0.01|Benign|0.3|tolerated|MGI:2385089|Cbwd1|COBW domain containing 1 [Source:MGI Symbol;Acc:MGI:2385089]|Heterozygous||T|C|26|39.5|Non-synonymous|Unprocessed|APF-G1
1552224|IGL00720|6|83570437|S->R||0.99|Probably damaging|0.09|tolerated|MGI:1917777|Stambp|STAM binding protein [Source:MGI Symbol;Acc:MGI:1917777]|Heterozygous|Mice homozygous for a knock-out allele die of starvation at weaning exhibiting postnatal growth retardation, limb-clasping, a hypocellular cerebral cortex, and severe loss of hippocampal CA1 neurons accompanied by apoptosis; one-third of mutant mice display blepharoptosis.|A|T|26|34.5|Non-synonymous|Unprocessed|APF-G1
1552225|IGL00720|11|55311244|T->A|||Benign|1.0|tolerated|MGI:2685369|Fat2|FAT tumor suppressor homolog 2 (Drosophila) [Source:MGI Symbol;Acc:MGI:2685369]|Heterozygous||T|C|25|35.0|Non-synonymous|Unprocessed|APF-G1
1552226|IGL00720|8|71684037|I->V||0.7|Possibly damaging|0.04|deleterious|MGI:99928|Jak3|Janus kinase 3 [Source:MGI Symbol;Acc:MGI:99928]|Heterozygous|Homozygous null mutants exhibit a severe B cell development block. Mutants have small thymi, and in response to mitogenic signals their peripheral T cells fail to proliferate and secrete only small amounts of IL-2. Point mutation homozygotes develop autoimmune inflammatory bowel disease.|A|G|24|39.0|Non-synonymous|Unprocessed|APF-G1
1552227|IGL00720|6|85910975|M->T|||N/A|||MGI:1913366|Cml1|camello-like 1 [Source:MGI Symbol;Acc:MGI:1913366]|Heterozygous||A|G|20|38.5|Non-synonymous|Unprocessed|APF-G1
1552228|IGL00720|8|13127735|K->E||0.08|Benign|0.14|tolerated|MGI:1914487|Cul4a|cullin 4A [Source:MGI Symbol;Acc:MGI:1914487]|Heterozygous|Mice homozygous for one knock-out allele exhibit reduced female fertility, male infertility, impaired spermatogenesis, and impaired DNA repair.|A|G|19|40.0|Non-synonymous|Unprocessed|APF-G1
1552229|IGL00720|8|95138016|V->A||0.17|Benign|0.15|tolerated|MGI:109202|Kifc3|kinesin family member C3 [Source:MGI Symbol;Acc:MGI:109202]|Heterozygous|Mice homozygous for this targeted mutation are viable, fertile, and appear phenotypically indistinguishable from wild-type littermates.|A|G|17|37.0|Non-synonymous|Unprocessed|APF-G1
1552772|IGL00721|12|75007676|P->L||0.01|Benign|0.01|deleterious|MGI:3584508|Kcnh5|potassium voltage-gated channel, subfamily H (eag-related), member 5 [Source:MGI Symbol;Acc:MGI:3584508]|Heterozygous||G|A|46|41.0|Non-synonymous|Unprocessed|APF-G1
1552773|IGL00721|9|83863448|I->T||1.0|Probably damaging||deleterious|MGI:1194921|Ttk|Ttk protein kinase [Source:MGI Symbol;Acc:MGI:1194921]|Heterozygous|Mice homozygous for a floxed allele activated in oocytes exhibit reduced female fertility associated with defective spindle assembly checkpoint, premature chromosome segregation, and accelerated anaphase and polar body extrusion.|T|C|38|40.0|Non-synonymous|Unprocessed|APF-G1
1552774|IGL00721|6|3963414|D->G||0.66|Possibly damaging|0.22|tolerated|MGI:108543|Tfpi2|tissue factor pathway inhibitor 2 [Source:MGI Symbol;Acc:MGI:108543]|Heterozygous||T|C|35|39.0|Non-synonymous|Unprocessed|APF-G1
1552775|IGL00721|2|66226778|S->A||0.19|Benign|0.03|deleterious|MGI:1920918|Ttc21b|tetratricopeptide repeat domain 21B [Source:MGI Symbol;Acc:MGI:1920918]|Heterozygous|Homozygous mutation of this gene is embryonic lethal. Mutant embryos exhibit several deformities including polydactyly, microphthalmia, irregular shape of the long bones, rib fusion and truncation, neural tube defects, and abnormal brain structure.|A|C|25|40.0|Non-synonymous|Unprocessed|APF-G1
1552776|IGL00721|15|12374412|V->A||0.01|Benign|0.39|tolerated|MGI:1922394|Pdzd2|PDZ domain containing 2 [Source:MGI Symbol;Acc:MGI:1922394]|Heterozygous|Mice homozygous for a gene trapped allele exhibit normal response to acute and chronic pain.|A|G|24|40.0|Non-synonymous|Unprocessed|APF-G1
1552777|IGL00721|3|72943579|N->K||1.0|Probably damaging|0.02|deleterious|MGI:97528|Sis|sucrase isomaltase (alpha-glucosidase) [Source:MGI Symbol;Acc:MGI:1917233]|Heterozygous||G|T|22|37.0|Non-synonymous|Unprocessed|APF-G1
1552778|IGL00721|2|52119117|S->P||1.0|Probably damaging||deleterious|MGI:1098622|Rif1|Rap1 interacting factor 1 homolog (yeast) [Source:MGI Symbol;Acc:MGI:1098622]|Heterozygous|Mice homozygous for a knock-out allele exhibit embryonic lethality.  Mice homozygous for a gene trap allele exhibit embryonic and postnatal lethality, reduced fertility, and decreased cell proliferation.|T|C|21|39.0|Non-synonymous|Unprocessed|APF-G1
1552779|IGL00721|15|71846177|G->E|||Unknown|0.05|tolerated|MGI:1916950|Col22a1|collagen, type XXII, alpha 1 [Source:MGI Symbol;Acc:MGI:1916950]|Heterozygous||C|T|20|40.0|Non-synonymous|Unprocessed|APF-G1
1552780|IGL00721|17|47680703|D->G||1.0|Probably damaging||deleterious|MGI:2685391, MGI:1929648|Med20,usp49|ubiquitin specific peptidase 49 [Source:MGI Symbol;Acc:MGI:2685391],mediator complex subunit 20 [Source:MGI Symbol;Acc:MGI:1929648]|Heterozygous||A|G|16|39.0|Non-synonymous|Unprocessed|APF-G1
1552781|IGL00721|3|37030751|Disrupted splicing|||N/A|||MGI:2444631|4932438a13rik|RIKEN cDNA 4932438A13 gene [Source:MGI Symbol;Acc:MGI:2444631]|Heterozygous||A|T|28|39.0|Splice|Unprocessed|APF-G1
1553275|IGL00722|3|35819935|I->T||1.0|Probably damaging||deleterious|MGI:1923545|Atp11b|ATPase, class VI, type 11B [Source:MGI Symbol;Acc:MGI:1923545]|Heterozygous||T|C|102|41.0|Non-synonymous|Unprocessed|APF-G1
1553276|IGL00722|1|53764140|S->G||0.98|Probably damaging||deleterious|MGI:2138162|Stk17b|serine/threonine kinase 17b (apoptosis-inducing) [Source:MGI Symbol;Acc:MGI:2138162]|Heterozygous|Homozygous null mice display abnormal T cell numbers, increased T cell proliferation, abnormal cytokine physiology, and decreased susceptibility to experimental autoimmune encephalomyelitis.|T|C|101|40.0|Non-synonymous|Unprocessed|APF-G1
1553277|IGL00722|9|110551136|S->P||1.0|Probably damaging|0.01|deleterious|MGI:1918177|Setd2|SET domain containing 2 [Source:MGI Symbol;Acc:MGI:1918177]|Heterozygous|Mice homozygous for a knock-out allele exhibit impaired embryonic vascular remodeling in the embryo proper, yolk sac, and placenta that leads to death around E10.5.|T|C|101|40.0|Non-synonymous|Unprocessed|APF-G1
1553278|IGL00722|12|30897793|D->G||1.0|Probably damaging||deleterious|MGI:87881|Acp1|acid phosphatase 1, soluble [Source:MGI Symbol;Acc:MGI:87881]|Heterozygous||T|C|55|39.0|Non-synonymous|Unprocessed|APF-G1
1553279|IGL00722|9|18456521|P->T||1.0|Probably damaging|0.01|deleterious|MGI:1921681|Zfp558|zinc finger protein 558 [Source:MGI Symbol;Acc:MGI:1921681]|Heterozygous||G|T|48|39.0|Non-synonymous|Unprocessed|APF-G1
1553280|IGL00722|17|78692420|D->G||1.0|Probably damaging||deleterious|MGI:1333757|Strn|striatin, calmodulin binding protein [Source:MGI Symbol;Acc:MGI:1333757]|Heterozygous||T|C|42|40.0|Non-synonymous|Unprocessed|APF-G1
1553281|IGL00722|3|138109015|V->F||0.53|Possibly damaging|0.02|deleterious|MGI:106926|Mttp|microsomal triglyceride transfer protein [Source:MGI Symbol;Acc:MGI:106926]|Heterozygous|Most embryos homozygous for a reporter allele die at midgestation displaying delayed growth, neurodevelopmental anomalies, impaired erythropoiesis, deficient yolk sac lipoprotein production, hemorrhage and necrosis. Heterozygous mutant mice display altered plasma lipid and lipoprotein profiles.|C|A|40|39.0|Non-synonymous|Unprocessed|APF-G1
1553282|IGL00722|1|52901320|V->A||0.97|Probably damaging|0.03|deleterious|MGI:1923792|Hibch|3-hydroxyisobutyryl-Coenzyme A hydrolase [Source:MGI Symbol;Acc:MGI:1923792]|Heterozygous||T|C|37|40.0|Non-synonymous|Unprocessed|APF-G1
1553283|IGL00722|3|127680213|S->P||0.91|Possibly damaging|0.08|tolerated|MGI:1918731|Alpk1|alpha-kinase 1 [Source:MGI Symbol;Acc:MGI:1918731]|Heterozygous||A|G|29|40.0|Non-synonymous|Unprocessed|APF-G1
1553284|IGL00722|4|109072010|I->V||0.58|Possibly damaging|0.01|deleterious|MGI:1923784|Osbpl9|oxysterol binding protein-like 9 [Source:MGI Symbol;Acc:MGI:1923784]|Heterozygous||T|C|25|40.0|Non-synonymous|Unprocessed|APF-G1
1553285|IGL00722|4|119531110|R->K||0.78|Possibly damaging||deleterious|MGI:3035485|Aa415398|expressed sequence AA415398 [Source:MGI Symbol;Acc:MGI:3035485]|Heterozygous||C|T|24|39.0|Non-synonymous|Unprocessed|APF-G1
1553286|IGL00722|9|35268418|V->D||0.94|Possibly damaging|0.01|deleterious|MGI:1919239|Rpusd4|RNA pseudouridylate synthase domain containing 4 [Source:MGI Symbol;Acc:MGI:1919239]|Heterozygous||T|A|18|39.0|Non-synonymous|Unprocessed|APF-G1
1553287|IGL00722|X|23732309|Disrupted splicing|||N/A|||MGI:1919654|Wdr44|WD repeat domain 44 [Source:MGI Symbol;Acc:MGI:1919654]|Heterozygous||T|C|68|41.0|Splice|Unprocessed|APF-G1
1553779|IGL00724|5|25189942|D->E||0.01|Benign|0.07|tolerated|MGI:1915159|Galntl5|UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 5 [Source:MGI Symbol;Acc:MGI:1915159]|Heterozygous||T|A|60|39.0|Non-synonymous|Unprocessed|APF-G1
1553780|IGL00724|7|90382769|Q->R|||N/A|0.32|tolerated|MGI:1933366|Sytl2|synaptotagmin-like 2 [Source:MGI Symbol;Acc:MGI:1933366]|Heterozygous|Mice homozygous for a null allele display abnormal gastric surface mucus cell morphology and reduced basal mucin secretion from gastric cells|A|G|59|36.0|Non-synonymous|Unprocessed|APF-G1
1553781|IGL00724|3|116618328|E->K||0.98|Probably damaging|0.01|deleterious|MGI:1920026|Sass6|spindle assembly 6 homolog (C. elegans) [Source:MGI Symbol;Acc:MGI:1920026]|Heterozygous||G|A|56|36.5|Non-synonymous|Unprocessed|APF-G1
1553782|IGL00724|3|95578253|F->I|||Benign|0.69|tolerated|MGI:1915231|Hormad1|HORMA domain containing 1 [Source:MGI Symbol;Acc:MGI:1915231]|Heterozygous|Homozgous mice are infertile because of meiosis arrest associated with impaired synaptonemal-complex formation.|T|A|47|39.0|Non-synonymous|Unprocessed|APF-G1
1553783|IGL00724|1|65062091|R->Q||0.94|Possibly damaging|0.15|tolerated|MGI:88524|Crygd|crystallin, gamma D [Source:MGI Symbol;Acc:MGI:88524]|Heterozygous|Heterozygotes for a spontaneous mutation exhibit a dense nuclear cataract and mild microphthalmia by 2-months of age, followed by posterior capsular rupture into the posterior vitreous by 3-months. In homozygotes, the microphthalmia is more pronounced.|C|T|42|37.0|Non-synonymous|Unprocessed|APF-G1
1553784|IGL00724|17|35383132|W->Stop|||N/A|||MGI:95933|H2-gs10|MHC class I like protein GS10 [Source:MGI Symbol;Acc:MGI:3808875]|Heterozygous||G|A|40|36.0|Non-synonymous|Unprocessed|APF-G1
1553785|IGL00724|5|107266260|M->L|||Benign|0.7|tolerated|MGI:104637|Tgfbr3|transforming growth factor, beta receptor III [Source:MGI Symbol;Acc:MGI:104637]|Heterozygous|Mice homozygous for disruptions in this gene usually die as embryos.  The very few individuals that survive are poorly fertile with abnormalities of the spleen, liver, heart, and skeletal system.|T|A|39|35.0|Non-synonymous|Unprocessed|APF-G1
1553786|IGL00724|8|93335179|V->A||0.97|Probably damaging|0.02|deleterious|MGI:88378|Ces1g|carboxylesterase 1G [Source:MGI Symbol;Acc:MGI:88378]|Heterozygous||A|G|38|35.5|Non-synonymous|Unprocessed|APF-G1
1553787|IGL00724|11|51715146|Y->H||1.0|Probably damaging||deleterious|MGI:1924621|Sec24a|Sec24 related gene family, member A (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1924621]|Heterozygous||A|G|34|38.5|Non-synonymous|Unprocessed|APF-G1
1553788|IGL00724|9|92584552|N->K||0.01|Benign|0.7|tolerated|MGI:1347007|Plod2|procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 [Source:MGI Symbol;Acc:MGI:1347007]|Heterozygous||T|A|31|39.0|Non-synonymous|Unprocessed|APF-G1
1553789|IGL00724|8|94039053|K->N|||Benign|0.51|tolerated|MGI:2442978|Ogfod1|2-oxoglutarate and iron-dependent oxygenase domain containing 1 [Source:MGI Symbol;Acc:MGI:2442978]|Heterozygous||A|T|30|37.5|Non-synonymous|Unprocessed|APF-G1
1553790|IGL00724|12|38173773|P->L|||Benign|0.4|tolerated|MGI:2442474|Dgkb|diacylglycerol kinase, beta [Source:MGI Symbol;Acc:MGI:2442474]|Heterozygous|Mice homozygous for a transposon distruption have defects in long term potentiation, synapase morphology, and in spatial reference and working memory.|C|T|29|37.0|Non-synonymous|Unprocessed|APF-G1
1553791|IGL00724|4|106676625|N->Y||1.0|Probably damaging||deleterious|MGI:1919604|Ttc4|tetratricopeptide repeat domain 4 [Source:MGI Symbol;Acc:MGI:1919604]|Heterozygous||T|A|29|37.0|Non-synonymous|Unprocessed|APF-G1
1553792|IGL00724|9|22258113|L->P||0.99|Probably damaging||deleterious|MGI:2679006|Zfp599|zinc finger protein 599 [Source:MGI Symbol;Acc:MGI:2679006]|Heterozygous||A|G|28|37.0|Non-synonymous|Unprocessed|APF-G1
1553793|IGL00724|8|95706548|T->S|||Benign|0.72|tolerated|MGI:2384590|Ndrg4|N-myc downstream regulated gene 4 [Source:MGI Symbol;Acc:MGI:2384590]|Heterozygous||A|T|27|34.0|Non-synonymous|Unprocessed|APF-G1
1553794|IGL00724|6|128550773|N->I||0.98|Probably damaging||deleterious|MGI:3039594|Bc048546|cDNA sequence BC048546 [Source:MGI Symbol;Acc:MGI:3039594]|Heterozygous||T|A|26|38.0|Non-synonymous|Unprocessed|APF-G1
1553795|IGL00724|5|29287441|Q->L||0.97|Probably damaging|0.03|deleterious|MGI:1861746|Lmbr1|limb region 1 [Source:MGI Symbol;Acc:MGI:1861746]|Heterozygous|Mice homozygous for a null allele show minor coalitions of distal wrist bones and a low incidence of limb defects, including oligodactyly, brachyphalangia, and soft tissue or bony syndactyly. Homozygotes for another null allele exhibit normal morphology, clinical chemistry, hematology and behavior.|T|A|24|38.5|Non-synonymous|Unprocessed|APF-G1
1553796|IGL00724|13|74150873|T->I||0.56|Possibly damaging||deleterious|MGI:105064|Slc9a3|solute carrier family 9 (sodium/hydrogen exchanger), member 3 [Source:MGI Symbol;Acc:MGI:105064]|Heterozygous|Homozygous mutant mice have diarrhea associated with defects of renal and intestinal absorption. Males are infertile.|C|T|23|35.0|Non-synonymous|Unprocessed|APF-G1
1553797|IGL00724|4|9475015|M->K||1.0|Probably damaging||deleterious|MGI:1914186|Asph|aspartate-beta-hydroxylase [Source:MGI Symbol;Acc:MGI:1914186]|Heterozygous|Homozygotes for a mutation lacking aspartyl beta-hydroxylase expression exhibit syndactyly, facial dysmorphology, mild hard palate defects, and reduced female fertility.|A|T|22|37.5|Non-synonymous|Unprocessed|APF-G1
1553798|IGL00724|1|106777328|V->E||1.0|Probably damaging||deleterious|MGI:1100499|Vps4b|vacuolar protein sorting 4b (yeast) [Source:MGI Symbol;Acc:MGI:1100499]|Heterozygous||A|T|17|40.0|Non-synonymous|Unprocessed|APF-G1
1553799|IGL00724|3|94872326|V->A||0.92|Possibly damaging|0.22|tolerated|MGI:2442117|Pogz|pogo transposable element with ZNF domain [Source:MGI Symbol;Acc:MGI:2442117]|Heterozygous||T|C|17|32.0|Non-synonymous|Unprocessed|APF-G1
1553800|IGL00724|1|125976964|S->P|||Benign|1.0|tolerated|MGI:2686394|Nckap5|NCK-associated protein 5 [Source:MGI Symbol;Acc:MGI:2686394]|Heterozygous||A|G|16|36.0|Non-synonymous|Unprocessed|APF-G1
1553801|IGL00724|3|40810391|Disrupted splicing|||N/A|||MGI:101783|Plk4|polo-like kinase 4 (Drosophila) [Source:MGI Symbol;Acc:MGI:101783]|Heterozygous|Mice homozygous for disruptions of this gene die before birth.  Development is arrested around E7.5.|T|C|100|39.0|Splice|Unprocessed|APF-G1
1553802|IGL00724|X|74016545|Disrupted splicing|||N/A|||MGI:107420|Irak1|interleukin-1 receptor-associated kinase 1 [Source:MGI Symbol;Acc:MGI:107420]|Heterozygous|Mice homozygous for disruptions in this gene display an essentially normal phenotype.  Cytokine production and response to endotoxin are attenuated however.|T|C|24|34.0|Splice|Unprocessed|APF-G1
1554272|IGL00725|5|76254413|Y->Stop|||N/A|||MGI:99698|Clock|circadian locomotor output cycles kaput [Source:MGI Symbol;Acc:MGI:99698]|Heterozygous|Mice homozygous for a knock-out allele exhibit abnormal circadian phase.  Mice homozygous for a spontaneous mutation exhibit abnormal circadian rhythm, reproduction, behavior, hair cycle, macronutrient absorption, and metabolism.|A|C|205|38.0|Non-synonymous|Unprocessed|APF-G1
1554273|IGL00725|16|15816639|N->S||0.04|Benign|0.21|tolerated|MGI:104779|Prkdc|protein kinase, DNA activated, catalytic polypeptide [Source:MGI Symbol;Acc:MGI:104779]|Heterozygous|Mutations at this locus effect genome stability, radiation sensitivity and DNA repair. Nonsense (scid) and null homozygotes have severe combined immunodeficiency. A BALB/c variant allele reduces enzyme activity and predisposes to breast cancer.|A|G|194|39.0|Non-synonymous|Unprocessed|APF-G1
1554274|IGL00725|14|60243440|T->K||0.16|Benign|0.93|tolerated|MGI:1919094|Nupl1|nucleoporin like 1 [Source:MGI Symbol;Acc:MGI:1919094]|Heterozygous||G|T|84|37.0|Non-synonymous|Unprocessed|APF-G1
1554275|IGL00725|12|13245690|L->P||0.97|Probably damaging||deleterious|MGI:2144727|Ddx1|DEAD (Asp-Glu-Ala-Asp) box polypeptide 1 [Source:MGI Symbol;Acc:MGI:2144727]|Heterozygous||A|G|69|37.0|Non-synonymous|Unprocessed|APF-G1
1554276|IGL00725|13|17662772|S->R||1.0|Probably damaging||deleterious|MGI:1923221|5033411d12rik|RIKEN cDNA 5033411D12 gene [Source:MGI Symbol;Acc:MGI:1923221]|Heterozygous||A|T|60|36.5|Non-synonymous|Unprocessed|APF-G1
1554277|IGL00725|3|35827073|R->L||1.0|Probably damaging||deleterious|MGI:1923545|Atp11b|ATPase, class VI, type 11B [Source:MGI Symbol;Acc:MGI:1923545]|Heterozygous||G|T|58|39.0|Non-synonymous|Unprocessed|APF-G1
1554278|IGL00725|3|103928821|S->P||0.71|Possibly damaging|0.01|deleterious|MGI:2444993|Rsbn1|rosbin, round spermatid basic protein 1 [Source:MGI Symbol;Acc:MGI:2444993]|Heterozygous||T|C|56|37.0|Non-synonymous|Unprocessed|APF-G1
1554279|IGL00725|1|173682861|I->T||0.6|Possibly damaging|0.23|tolerated|MGI:2442822|Pydc3|pyrin domain containing 3 [Source:MGI Symbol;Acc:MGI:2442822]|Heterozygous||T|C|51|37.0|Non-synonymous|Unprocessed|APF-G1
1554280|IGL00725|10|5344922|Y->C||0.01|Benign|0.02|deleterious|MGI:1927152|Syne1|synaptic nuclear envelope 1 [Source:MGI Symbol;Acc:MGI:1927152]|Heterozygous|Mice homozygous for an allele lacking the KASH domain exhibit neonatal and postnatal lethality, progressive muscular dystrophy, and limb weakness.|A|G|50|35.0|Non-synonymous|Unprocessed|APF-G1
1554281|IGL00725|2|77188522|I->V|||Benign|0.98|tolerated|MGI:1916262|Sestd1|SEC14 and spectrin domains 1 [Source:MGI Symbol;Acc:MGI:1916262]|Heterozygous||T|C|49|35.0|Non-synonymous|Unprocessed|APF-G1
1554282|IGL00725|3|144839162|D->N||0.99|Probably damaging|0.27|tolerated|MGI:2181989|Clca4|chloride channel calcium activated 4 [Source:MGI Symbol;Acc:MGI:2181989]|Heterozygous||C|T|48|37.0|Non-synonymous|Unprocessed|APF-G1
1554283|IGL00725|6|106662655|V->E||1.0|Probably damaging||deleterious|MGI:1095737|Cntn4|contactin 4 [Source:MGI Symbol;Acc:MGI:1095737]|Heterozygous|Mice homozygous for a knock-out allele exhibit aberrant projection of olfactory axons to multiple glomeruli in the olfactory bulb.|T|A|44|37.0|Non-synonymous|Unprocessed|APF-G1
1554284|IGL00725|7|118730723|D->G||1.0|Probably damaging||deleterious|MGI:2141942|6330503k22rik|RIKEN cDNA 6330503K22 gene [Source:MGI Symbol;Acc:MGI:2141942]|Heterozygous||A|G|39|35.0|Non-synonymous|Unprocessed|APF-G1
1554285|IGL00725|5|31174408|V->A||0.97|Probably damaging|0.01|deleterious|MGI:1919002|Gtf3c2|general transcription factor IIIC, polypeptide 2, beta [Source:MGI Symbol;Acc:MGI:1919002]|Heterozygous||A|G|31|37.0|Non-synonymous|Unprocessed|APF-G1
1554286|IGL00725|6|13187412|V->A|||Benign|0.93|tolerated|MGI:2685313|Vwde|von Willebrand factor D and EGF domains [Source:MGI Symbol;Acc:MGI:2685313]|Heterozygous||A|G|31|39.0|Non-synonymous|Unprocessed|APF-G1
1554287|IGL00725|10|84594710|I->T||0.45|Possibly damaging|0.01|deleterious|MGI:2444679|Tcp11l2|t-complex 11 (mouse) like 2 [Source:MGI Symbol;Acc:MGI:2444679]|Heterozygous||T|C|28|39.0|Non-synonymous|Unprocessed|APF-G1
1554288|IGL00725|3|146596378|T->I||0.02|Benign|0.09|tolerated|MGI:1913283|Dnase2b|deoxyribonuclease II beta [Source:MGI Symbol;Acc:MGI:1913283]|Heterozygous|The inability of homozygous mutant mice to degrade DNA in differentiating lens cells leads to cataract formation in the nucleus lentis. Consequently, mutant mice exhibit an impaired response to light.|G|A|26|37.0|Non-synonymous|Unprocessed|APF-G1
1554289|IGL00725|11|100190006|E->V||1.0|Probably damaging|0.02|deleterious|MGI:96696|Krt9|keratin 9 [Source:MGI Symbol;Acc:MGI:96696]|Heterozygous||T|A|25|39.0|Non-synonymous|Unprocessed|APF-G1
1554290|IGL00725|7|25764483|D->E||1.0|Probably damaging|1.0|tolerated|MGI:1347244|Axl|AXL receptor tyrosine kinase [Source:MGI Symbol;Acc:MGI:1347244]|Heterozygous|Homozygous mutant mice are phenotypically normal, however in conjunction with mutations in other related receptor tyrosine kinases, mutations of this gene results in fertility defects, autoimmunity abnormalities, and aberrant apoptosis.|A|T|24|39.0|Non-synonymous|Unprocessed|APF-G1
1554291|IGL00725|18|60604077|V->I|||N/A|0.04|deleterious|MGI:1099446|Synpo|synaptopodin [Source:MGI Symbol;Acc:MGI:1099446]|Heterozygous|Mice homozygous for disruptions in this gene display abnormalities in telencephalic neurons, reduced long term potentiation, and behavioral abnormalities including hypoactivity, reduced anxiety, and learning deficiencies.|C|T|18|39.0|Non-synonymous|Unprocessed|APF-G1
1554292|IGL00725|7|46274092|S->G||1.0|Probably damaging|0.1|tolerated|MGI:1202064|Otog|otogelin [Source:MGI Symbol;Acc:MGI:1202064]|Heterozygous|Homozygotes for a number of different spontaneous and targeted mutations exhibit vestibular dysfunction, including circling, head tilt, impaired balance, coordination, and placing response. Mutants have impaired hearing, decreased brain stem auditory evoked potential, and ear abnormalities.|A|G|18|35.0|Non-synonymous|Unprocessed|APF-G1
1554293|IGL00725|17|14988066|Disrupted splicing|||N/A|||MGI:3583895|9030025p20rik|RIKEN cDNA 9030025P20 gene [Source:MGI Symbol;Acc:MGI:3583895]|Heterozygous||T|C|332|39.0|Splice|Unprocessed|APF-G1
1554294|IGL00725|12|13227459|Disrupted splicing|||N/A|||MGI:2144727|Ddx1|DEAD (Asp-Glu-Ala-Asp) box polypeptide 1 [Source:MGI Symbol;Acc:MGI:2144727]|Heterozygous||A|G|20|37.0|Splice|Unprocessed|APF-G1
1554770|IGL00726|15|103242437|D->G|||Unknown|0.18|tolerated|MGI:104820|Hnrnpa1|heterogeneous nuclear ribonucleoprotein A1 [Source:MGI Symbol;Acc:MGI:104820]|Heterozygous||A|G|83|34.0|Non-synonymous|Unprocessed|APF-G1
1554771|IGL00726|2|76734725|D->A||0.99|Probably damaging|||MGI:98864|Ttn|titin [Source:MGI Symbol;Acc:MGI:98864]|Heterozygous|Homozygous mutant mice show embryogenesis defects in frontonasal mass, first branchial arch and somites, and vascular, cardiac and skeletal muscle defects causing growth retardation, muscle weakness, abnormal posture, and premature death ranging from embryonic day 11.5 to 8 weeks of age.|T|G|54|37.0|Non-synonymous|Unprocessed|APF-G1
1554772|IGL00726|4|136010765|K->E||0.15|Benign|0.16|tolerated|MGI:1351315|Tceb3|transcription elongation factor B (SIII), polypeptide 3 [Source:MGI Symbol;Acc:MGI:1351315]|Heterozygous|Embryos homozygous for a knock-out allele are severely growth retarded, exhibit a wide range of developmental anomalies and die between E10.5 and E12.5, most likely due to massive apoptosis while mutant MEFs show increased apoptosis and senescence-like growth defects.|T|C|38|38.5|Non-synonymous|Unprocessed|APF-G1
1554773|IGL00726|6|14717852|V->A||0.45|Possibly damaging|0.12|tolerated|MGI:2153588|Ppp1r3a|protein phosphatase 1, regulatory (inhibitor) subunit 3A [Source:MGI Symbol;Acc:MGI:2153588]|Heterozygous|Homozygous mutant mice have reduced levels of skeletal muscle glycogen. Whereas one model was normoglycemic and grossly normal, another on a similar genetic background was glucose intolerant, insulin resistant, and gained weight to the point of obesity.|A|G|36|37.0|Non-synonymous|Unprocessed|APF-G1
1554774|IGL00726|1|166630392|F->Y||0.11|Benign|0.29|tolerated|MGI:3643320|Gm4847|predicted gene 4847 [Source:MGI Symbol;Acc:MGI:3643320]|Heterozygous||A|T|32|35.0|Non-synonymous|Unprocessed|APF-G1
1554775|IGL00726|3|28532898|E->G||1.0|Probably damaging||deleterious|MGI:1916264|Tnik|TRAF2 and NCK interacting kinase [Source:MGI Symbol;Acc:MGI:1916264]|Heterozygous||A|G|28|37.0|Non-synonymous|Unprocessed|APF-G1
1554776|IGL00726|5|21480342|N->K||1.0|Probably damaging||deleterious|MGI:2140983|Fam185a|family with sequence similarity 185, member A [Source:MGI Symbol;Acc:MGI:2140983]|Heterozygous||T|A|27|38.0|Non-synonymous|Unprocessed|APF-G1
1554777|IGL00726|8|123258337|S->P||0.04|Benign|0.32|tolerated|MGI:1888495|Zfp276|zinc finger protein (C2H2 type) 276 [Source:MGI Symbol;Acc:MGI:1888495]|Heterozygous||T|C|21|35.0|Non-synonymous|Unprocessed|APF-G1
1554778|IGL00726|17|46528096|N->I||1.0|Probably damaging||deleterious|MGI:1925559|Cul9|cullin 9 [Source:MGI Symbol;Acc:MGI:1925559]|Heterozygous|Mice homozygous for a knock-out allele exhibit decreased body weight, increased incidence of tumors, and decreased cellular sensitivity to radiation-induced apoptosis.|T|A|16|30.0|Non-synonymous|Unprocessed|APF-G1
1554779|IGL00726|6|106738489|N->I||1.0|Probably damaging||deleterious|MGI:96558|Il5ra|interleukin 5 receptor, alpha [Source:MGI Symbol;Acc:MGI:96558]|Heterozygous|Mice homozygous for disruptions in this gene display a generally normal phenotype but with some immune system deficiencies.|T|A|16|38.0|Non-synonymous|Unprocessed|APF-G1
1554780|IGL00726|12|40790068|Disrupted splicing|||N/A|||MGI:1918006|Dock4|dedicator of cytokinesis 4 [Source:MGI Symbol;Acc:MGI:1918006]|Heterozygous||T|A|50|35.0|Splice|Unprocessed|APF-G1
1554781|IGL00726|1|150806366|Disrupted splicing|||N/A|||MGI:2685047|Hmcn1|hemicentin 1 [Source:MGI Symbol;Acc:MGI:2685047]|Heterozygous||A|G|16|38.0|Splice|Unprocessed|APF-G1
1555209|IGL00727|10|108230473|R->Q||0.95|Possibly damaging|0.82|tolerated|MGI:1309528|Ppp1r12a|protein phosphatase 1, regulatory (inhibitor) subunit 12A [Source:MGI Symbol;Acc:MGI:1309528]|Heterozygous|Homozygous null mice die before E7.5.|G|A|46|35.0|Non-synonymous|Unprocessed|APF-G1
1555210|IGL00727|15|99322670|T->I||0.4|Benign|0.4|tolerated|MGI:109569|Fmnl3|formin-like 3 [Source:MGI Symbol;Acc:MGI:109569]|Heterozygous||G|A|34|36.5|Non-synonymous|Unprocessed|APF-G1
1555211|IGL00727|13|81524684|Y->F||0.15|Benign|0.69|tolerated|MGI:1274784|Gpr98|G protein-coupled receptor 98 [Source:MGI Symbol;Acc:MGI:1274784]|Heterozygous|Homozygotes for a spontaneous and a targeted mutation exhibit high sensitivity to audiogenic seizures. Targeted mutant mice lack the ankle links that connect growing stereocilia in the developing cochlear hair cells.|T|A|26|35.5|Non-synonymous|Unprocessed|APF-G1
1555212|IGL00727|6|129831509|Y->H||0.14|Benign|0.17|tolerated|MGI:2180674|Klra17|killer cell lectin-like receptor, subfamily A, member 17 [Source:MGI Symbol;Acc:MGI:2180674]|Heterozygous|Mice homozygous for a knock-in allele exhibit reduced plasmacytoid dendritic cell number and function.|A|G|26|37.0|Non-synonymous|Unprocessed|APF-G1
1555213|IGL00727|7|6066702|E->G||0.88|Possibly damaging|0.02|deleterious|MGI:1890518|Nlrp4c|NLR family, pyrin domain containing 4C [Source:MGI Symbol;Acc:MGI:1890518]|Heterozygous||A|G|26|36.5|Non-synonymous|Unprocessed|APF-G1
1555214|IGL00727|8|25641158|S->P||1.0|Probably damaging|0.04|deleterious|MGI:2142581|Whsc1l1|Wolf-Hirschhorn syndrome candidate 1-like 1 (human) [Source:MGI Symbol;Acc:MGI:2142581]|Heterozygous||T|C|26|37.0|Non-synonymous|Unprocessed|APF-G1
1555215|IGL00727|9|78435488|P->L||1.0|Probably damaging|0.02|deleterious|MGI:2442261|E330016a19rik|RIKEN cDNA E330016A19 gene [Source:MGI Symbol;Acc:MGI:2442261]|Heterozygous||G|A|21|39.0|Non-synonymous|Unprocessed|APF-G1
1555216|IGL00727|12|50364661|R->H||0.99|Probably damaging||deleterious|MGI:99879|Prkd1|protein kinase D1 [Source:MGI Symbol;Acc:MGI:99879]|Heterozygous|Mice homozygous for a knock-out allele exhibit embryonic lethality.|C|T|20|35.0|Non-synonymous|Unprocessed|APF-G1
1555217|IGL00727|3|92824427|S->T||0.65|Possibly damaging|0.58|tolerated|MGI:1920981|Kprp|keratinocyte expressed, proline-rich [Source:MGI Symbol;Acc:MGI:1920981]|Heterozygous||A|T|20|35.0|Non-synonymous|Unprocessed|APF-G1
1555218|IGL00727|4|128745844|V->G||1.0|Probably damaging||deleterious|MGI:1860454|Phc2|polyhomeotic-like 2 (Drosophila) [Source:MGI Symbol;Acc:MGI:1860454]|Heterozygous|Mice homozygous for a knock-out allele have normal skulls but exhibit posterior homeotic transformations of the axial skeleton. Cultured mouse embryonic fibroblasts show defects in proliferation and premature senescence.|T|G|18|34.0|Non-synonymous|Unprocessed|APF-G1
1555219|IGL00727|6|149006716|Disrupted splicing|||N/A|||MGI:2444273|Dennd5b|DENN/MADD domain containing 5B [Source:MGI Symbol;Acc:MGI:2444273]|Heterozygous||G|T|51|37.0|Splice|Unprocessed|APF-G1
1555220|IGL00727|3|158063871|Disrupted splicing|||N/A|||MGI:1914394|Lrrc40|leucine rich repeat containing 40 [Source:MGI Symbol;Acc:MGI:1914394]|Heterozygous||T|C|21|35.0|Splice|Unprocessed|APF-G1
1556571|IGL00730|3|98630057|S->T||0.99|Probably damaging|0.35|tolerated|MGI:104645|Hsd3b5|hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5 [Source:MGI Symbol;Acc:MGI:104645]|Heterozygous||A|T|70|36.0|Non-synonymous|Unprocessed|APF-G1
1556572|IGL00730|1|60147418|Q->Stop|||N/A|||MGI:2182269|Carf|calcium response factor [Source:MGI Symbol;Acc:MGI:2182269]|Heterozygous|Mice homozygous for a null allele have aberrant learning and memory.|C|T|60|36.0|Non-synonymous|Unprocessed|APF-G1
1556573|IGL00730|3|96868426|D->G|||Benign|0.12|tolerated|MGI:1928901|Pdzk1|PDZ domain containing 1 [Source:MGI Symbol;Acc:MGI:1928901]|Heterozygous|Homozygous mutation of this gene results in increased serum cholesterol levels.|A|G|60|37.0|Non-synonymous|Unprocessed|APF-G1
1556574|IGL00730|14|16389831|Y->C||1.0|Probably damaging||deleterious|MGI:98791|Top2b|topoisomerase (DNA) II beta [Source:MGI Symbol;Acc:MGI:98791]|Heterozygous|Homozygous null mice exhibit abnormal innervation. Offspring die shortly after birth due to respiratory failure.|A|G|55|39.0|Non-synonymous|Unprocessed|APF-G1
1556575|IGL00730|9|78435488|P->L||1.0|Probably damaging|0.02|deleterious|MGI:2442261|E330016a19rik|RIKEN cDNA E330016A19 gene [Source:MGI Symbol;Acc:MGI:2442261]|Heterozygous||G|A|54|38.0|Non-synonymous|Unprocessed|APF-G1
1556576|IGL00730|12|87077206|L->Q||0.04|Benign|0.29|tolerated|MGI:2444386|Tmem63c|transmembrane protein 63c [Source:MGI Symbol;Acc:MGI:2444386]|Heterozygous||T|A|47|39.0|Non-synonymous|Unprocessed|APF-G1
1556577|IGL00730|12|11261067|N->D||1.0|Probably damaging||deleterious|MGI:2443149|Gen1|Gen homolog 1, endonuclease (Drosophila) [Source:MGI Symbol;Acc:MGI:2443149]|Heterozygous||T|C|45|38.0|Non-synonymous|Unprocessed|APF-G1
1556578|IGL00730|18|80128032|I->N|||Benign|0.5|tolerated|MGI:2448562|Adnp2|ADNP homeobox 2 [Source:MGI Symbol;Acc:MGI:2448562]|Heterozygous||A|T|38|34.0|Non-synonymous|Unprocessed|APF-G1
1556579|IGL00730|10|116113026|D->E|||Benign|1.0|tolerated|MGI:3588269, MGI:109559|4933416c03rik,ptprr|RIKEN cDNA 4933416C03 gene [Source:MGI Symbol;Acc:MGI:3588269],protein tyrosine phosphatase, receptor type, R [Source:MGI Symbol;Acc:MGI:109559]|Heterozygous|NO_PHENOTYPE,Mice homozygous for a knock-out allele exhibit increased ERK1/2 phosphorylation levels in cerebellar Purkinje cells, decreased grip strength, and ataxia characterized by fine motor coordination and balance defects.|A|C|35|38.0|Non-synonymous|Unprocessed|APF-G1
1556580|IGL00730|15|63897804|R->W||1.0|Probably damaging|0.01|deleterious|MGI:1921798|Gsdmc4|gasdermin C4 [Source:MGI Symbol;Acc:MGI:1921798]|Heterozygous||T|A|31|33.0|Non-synonymous|Unprocessed|APF-G1
1556581|IGL00730|1|13647516|Disrupted splicing|||N/A|||MGI:2442551|Lactb2|lactamase, beta 2 [Source:MGI Symbol;Acc:MGI:2442551]|Heterozygous|Male mice homozygous for a null allele exhibit at 40 days of age preceeded by decreased body size, lethargy, enlarged and pale liver and hepatic steatosis.|T|G|189|39.0|Splice|Unprocessed|APF-G1
1556582|IGL00730|9|21419549|Disrupted splicing|||N/A|||MGI:1931441|Qtrt1|queuine tRNA-ribosyltransferase 1 [Source:MGI Symbol;Acc:MGI:1931441]|Heterozygous|Mice heterozygous or homozygous for a gene trap allele exhibit reduced phenylalanine conversion to tyrosine and reduced cell levels of queuosine-modified tRNA.|G|T|39|37.0|Splice|Unprocessed|APF-G1
1556583|IGL00730|5|139151668|Disrupted splicing|||N/A|||MGI:3616079|Heatr2|HEAT repeat containing 2 [Source:MGI Symbol;Acc:MGI:3616079]|Heterozygous||G|T|31|38.0|Splice|Unprocessed|APF-G1
1556584|IGL00730|10|77942915|Disrupted splicing|||N/A|||MGI:1351901|Trpm2|transient receptor potential cation channel, subfamily M, member 2 [Source:MGI Symbol;Acc:MGI:1351901]|Heterozygous|Mice homozygous for a knock-out allele display impaired reactive oxygen species (ROS)-induced chemokine production in monocytes, and reduced neutrophil infiltration and ulceration in a dextran sulfate sodium-induced colitis inflammation model.|T|C|29|37.0|Splice|Unprocessed|APF-G1
1559561|IGL00731|3|142546428|S->P|||Benign|0.39|tolerated|MGI:2444421|Gbp7|guanylate binding protein 7 [Source:MGI Symbol;Acc:MGI:2444421]|Heterozygous||T|C|127|38.0|Non-synonymous|Unprocessed|APF-G1
1559562|IGL00731|12|55702452|S->P||0.23|Benign|0.27|tolerated|MGI:1931050|Ralgapa1|Ral GTPase activating protein, alpha subunit 1 [Source:MGI Symbol;Acc:MGI:1931050]|Heterozygous||A|G|95|37.0|Non-synonymous|Unprocessed|APF-G1
1559563|IGL00731|2|73362613|L->P||0.96|Probably damaging||deleterious|MGI:1915776|Gpr155|G protein-coupled receptor 155 [Source:MGI Symbol;Acc:MGI:1915776]|Heterozygous||A|G|58|37.0|Non-synonymous|Unprocessed|APF-G1
1559564|IGL00731|2|90768643|V->L|||Benign|0.84|tolerated|MGI:1860513|Fnbp4|formin binding protein 4 [Source:MGI Symbol;Acc:MGI:1860513]|Heterozygous||G|T|57|37.0|Non-synonymous|Unprocessed|APF-G1
1559565|IGL00731|9|78435488|P->L||1.0|Probably damaging|0.02|deleterious|MGI:2442261|E330016a19rik|RIKEN cDNA E330016A19 gene [Source:MGI Symbol;Acc:MGI:2442261]|Heterozygous||G|A|52|39.0|Non-synonymous|Unprocessed|APF-G1
1559566|IGL00731|1|16107875|N->D|||Benign|0.58|tolerated|MGI:1924238|Rdh10|retinol dehydrogenase 10 (all-trans) [Source:MGI Symbol;Acc:MGI:1924238]|Heterozygous|Embryos homozygous for an ENU-induced mutation exhibit mid-gestational lethality and abnormal limb, craniofacial, cranial ganglia, lung, pancreas, liver, and reproductive system morphology.|A|G|33|35.0|Non-synonymous|Unprocessed|APF-G1
1559567|IGL00731|7|44105923|E->G||0.4|Benign|0.02|deleterious|MGI:892022|Klk1b21|kallikrein 1-related peptidase b21 [Source:MGI Symbol;Acc:MGI:892022]|Heterozygous||A|G|29|38.0|Non-synonymous|Unprocessed|APF-G1
1559568|IGL00731|15|6435710|S->P||0.8|Possibly damaging|0.04|deleterious|MGI:109175|Dab2|disabled homolog 2 (Drosophila) [Source:MGI Symbol;Acc:MGI:109175]|Heterozygous|Homozygous null mutants exhibit abnormal primitive endoderm structure and/or function, lack a proamniotic cavity and die prior to embryonic day 9.5. A conditional mutant survives, but shows kidney proximal tubule abnormality.|T|C|28|35.5|Non-synonymous|Unprocessed|APF-G1
1559569|IGL00731|2|103266840|V->M||1.0|Probably damaging||deleterious|MGI:1270840|Ehf|ets homologous factor [Source:MGI Symbol;Acc:MGI:1270840]|Heterozygous||C|T|28|35.0|Non-synonymous|Unprocessed|APF-G1
1559570|IGL00731|1|165572614|F->L|||Benign|1.0|tolerated|MGI:2660854|Adcy10|adenylate cyclase 10 [Source:MGI Symbol;Acc:MGI:2660854]|Heterozygous|Homozygous null male mutants are infertile with a severe sperm motility defect, female null mutants are fertile. Females exhibit increased cholesterol and triglyceride levels while both sexes have a slight increase in heart rate.|T|C|25|37.0|Non-synonymous|Unprocessed|APF-G1
1559571|IGL00731|1|157157764|D->E||0.03|Benign|0.15|tolerated|MGI:2443881|Rasal2|RAS protein activator like 2 [Source:MGI Symbol;Acc:MGI:2443881]|Heterozygous||A|C|22|39.5|Non-synonymous|Unprocessed|APF-G1
1559572|IGL00731|9|53562086|E->K||0.52|Possibly damaging|0.25|tolerated|MGI:107605|Npat|nuclear protein in the AT region [Source:MGI Symbol;Acc:MGI:107605]|Heterozygous||G|A|22|33.5|Non-synonymous|Unprocessed|APF-G1
1559573|IGL00731|11|35622154|D->Y||0.83|Possibly damaging||deleterious|MGI:1315202|Slit3|slit homolog 3 (Drosophila) [Source:MGI Symbol;Acc:MGI:1315202]|Heterozygous|Mice homozygous for a gene trap allele show congenital diaphragmatic hernia (CDH), variable renal defects and enlarged heart right ventricles. Mice homozygous for either of two reporter alleles show diaphragm dysgenesis and die prematurely; those with end-stage CDH show dyspnea and lung congestion.|G|T|21|38.0|Non-synonymous|Unprocessed|APF-G1
1559574|IGL00731|16|16860919|T->A|||Benign|||MGI:96529|Igll1|immunoglobulin lambda-like polypeptide 1 [Source:MGI Symbol;Acc:MGI:96529]|Heterozygous||T|C|20|36.0|Non-synonymous|Unprocessed|APF-G1
1559575|IGL00731|7|101508099|Y->C|||Benign|0.06|tolerated|MGI:2446107|Pde2a|phosphodiesterase 2A, cGMP-stimulated [Source:MGI Symbol;Acc:MGI:2446107]|Heterozygous|Mice homozygous for a knock-out allele exhibit lethality between E17 and E18.|A|G|17|39.0|Non-synonymous|Unprocessed|APF-G1
1559576|IGL00731|18|53384609|Disrupted splicing|||N/A|||MGI:1916476|Snx24|sorting nexing 24 [Source:MGI Symbol;Acc:MGI:1916476]|Heterozygous||C|T|164|39.0|Splice|Unprocessed|APF-G1
1559577|IGL00731|3|132904657|Disrupted splicing|||N/A|||MGI:2148811|Npnt|nephronectin [Source:MGI Symbol;Acc:MGI:2148811]|Heterozygous|Mice homozygous for a null allele frequently exhibit kidney agenesis or hypoplasia attributed to a delay in the invasion of the metanephric mesenchyme by the ureteric bud at an early stage of kidney development.|C|T|50|38.0|Splice|Unprocessed|APF-G1
1559578|IGL00731|18|44108110|Disrupted splicing|||N/A|||MGI:1925492|Spink12|serine peptidase inhibitor, Kazal type 11 [Source:MGI Symbol;Acc:MGI:1925492]|Heterozygous||G|A|37|37.0|Splice|Unprocessed|APF-G1
1559579|IGL00731|8|111044869|Disrupted splicing|||N/A|||MGI:2384560|Aars|alanyl-tRNA synthetase [Source:MGI Symbol;Acc:MGI:2384560]|Heterozygous|Mice homozygous for a spontaneous point mutation have a rough, unkempt and sticky fur, display follicular dystrophy and patchy hair loss, develop tremors that progress to ataxia, and exhibit extensive loss of cerebellar Purkinje cells by 6 weeks of age.|A|G|19|35.0|Splice|Unprocessed|APF-G1
1560056|IGL00732|3|116618328|E->K||0.98|Probably damaging|0.01|deleterious|MGI:1920026|Sass6|spindle assembly 6 homolog (C. elegans) [Source:MGI Symbol;Acc:MGI:1920026]|Heterozygous||G|A|92|37.0|Non-synonymous|Unprocessed|APF-G1
1560057|IGL00732|7|116364500|A->V||0.11|Benign|0.05|deleterious|MGI:1203729|Pik3c2a|phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide [Source:MGI Symbol;Acc:MGI:1203729]|Heterozygous|Mice homozygous for a gene trap allele exhibit chronic renal failure and a range of renal lesions that precedes immune involvement.|G|A|80|37.0|Non-synonymous|Unprocessed|APF-G1
1560058|IGL00732|17|30656641|Y->C||1.0|Probably damaging||deleterious|MGI:107714|Dnahc8|dynein, axonemal, heavy chain 8 [Source:MGI Symbol;Acc:MGI:107714]|Heterozygous||A|G|61|34.0|Non-synonymous|Unprocessed|APF-G1
1560059|IGL00732|X|167374142|I->N||0.74|Possibly damaging||deleterious|MGI:97776|Prps2|phosphoribosyl pyrophosphate synthetase 2 [Source:MGI Symbol;Acc:MGI:97776]|Heterozygous||A|T|57|37.0|Non-synonymous|Unprocessed|APF-G1
1560060|IGL00732|1|65062091|R->Q||0.94|Possibly damaging|0.15|tolerated|MGI:88524|Crygd|crystallin, gamma D [Source:MGI Symbol;Acc:MGI:88524]|Heterozygous|Heterozygotes for a spontaneous mutation exhibit a dense nuclear cataract and mild microphthalmia by 2-months of age, followed by posterior capsular rupture into the posterior vitreous by 3-months. In homozygotes, the microphthalmia is more pronounced.|C|T|51|38.0|Non-synonymous|Unprocessed|APF-G1
1560061|IGL00732|16|76293061|T->I||0.16|Benign|0.24|tolerated|MGI:1315213|Nrip1|nuclear receptor interacting protein 1 [Source:MGI Symbol;Acc:MGI:1315213]|Heterozygous|Homozygosity for targeted disruption of this gene results in female infertility due to ovulation failure. Heterozygous females are partially affected.  Male and female mice are smaller than wild-type littermates.|G|A|48|36.0|Non-synonymous|Unprocessed|APF-G1
1560062|IGL00732|8|111670418|G->D||0.97|Probably damaging|0.05|deleterious|MGI:99154|Zfp1|zinc finger protein 1 [Source:MGI Symbol;Acc:MGI:99154]|Heterozygous||G|A|36|34.5|Non-synonymous|Unprocessed|APF-G1
1560063|IGL00732|6|47880390|P->S||1.0|Probably damaging||deleterious|MGI:2141413|Zfp282|zinc finger protein 282 [Source:MGI Symbol;Acc:MGI:2141413]|Heterozygous||C|T|23|33.0|Non-synonymous|Unprocessed|APF-G1
1560064|IGL00732|1|17091740|S->P||0.98|Probably damaging|0.1|tolerated|MGI:1891495|Jph1|junctophilin 1 [Source:MGI Symbol;Acc:MGI:1891495]|Heterozygous|Homozygotes for a targeted null mutation fail to suckle and die shortly after birth. Mutants exhibit deficiencies of triad junctions and contraction in skeletal muscle.|A|G|22|35.0|Non-synonymous|Unprocessed|APF-G1
1560571|IGL00733|14|101915702|S->T||0.99|Probably damaging|0.01|deleterious|MGI:1353586|Lmo7|LIM domain only 7 [Source:MGI Symbol;Acc:MGI:1353586]|Heterozygous|Targeted mutations in this gene result in postnatal lethality, growth defects, skeletal muscle abnormalities and retinal defects reflective of retinal degeneration.|T|A|292|38.0|Non-synonymous|Unprocessed|APF-G1
1560572|IGL00733|17|21739502|N->I||0.7|Possibly damaging|0.15|tolerated|MGI:2679295|Zfp229|zinc finger protein [Source:MGI Symbol;Acc:MGI:2679295]|Heterozygous||A|T|222|36.0|Non-synonymous|Unprocessed|APF-G1
1560573|IGL00733|9|97483049|V->A||1.0|Probably damaging|0.03|deleterious|MGI:1929897|Clstn2|calsyntenin 2 [Source:MGI Symbol;Acc:MGI:1929897]|Heterozygous||A|G|55|37.0|Non-synonymous|Unprocessed|APF-G1
1560574|IGL00733|16|95296463|E->K||1.0|Probably damaging||deleterious|MGI:1310000|Kcnj15|potassium inwardly-rectifying channel, subfamily J, member 15 [Source:MGI Symbol;Acc:MGI:1310000]|Heterozygous||G|A|31|35.0|Non-synonymous|Unprocessed|APF-G1
1560575|IGL00733|4|123124409|I->F||0.15|Benign|0.32|tolerated|MGI:107335|Bmp8b|bone morphogenetic protein 8b [Source:MGI Symbol;Acc:MGI:107335]|Heterozygous|Incidence of lethality among homozygous null mutants is variable depending on genetic background and due to allantoic and embryonic abnormalities. Heterozygous and surviving homozygous males exhibit varying degrees of germ cell deficiency and infertility, also background dependent.|A|T|29|36.0|Non-synonymous|Unprocessed|APF-G1
1560576|IGL00733|7|3240757|Y->C||0.96|Probably damaging|0.27|tolerated|MGI:2676630|Nlrp12|NLR family, pyrin domain containing 12 [Source:MGI Symbol;Acc:MGI:2676630]|Heterozygous||T|C|26|36.0|Non-synonymous|Unprocessed|APF-G1
1560577|IGL00733|16|11403502|T->I||0.98|Probably damaging|0.02|deleterious|MGI:1921728|Rundc2a|RUN domain containing 2A [Source:MGI Symbol;Acc:MGI:2686583]|Heterozygous||C|T|18|34.5|Non-synonymous|Unprocessed|APF-G1
1560578|IGL00733|9|32752926|Disrupted splicing|||N/A|||MGI:95455|Ets1|E26 avian leukemia oncogene 1, 5' domain [Source:MGI Symbol;Acc:MGI:95455]|Heterozygous|Homozygotes for targeted null mutations exhibit reduced numbers of peripheral CD8+ T cells, impaired TCR-mediated activation of both CD4+ and CD8+ T cells, increased numbers of IgM-secreting plasma cells, and severely impaired NK cell development.|T|A|38|37.0|Splice|Unprocessed|APF-G1
1561097|IGL00736|15|85129700|E->G||0.11|Benign|0.04|deleterious|MGI:2154049|Smc1b|structural maintenance of chromosomes 1B [Source:MGI Symbol;Acc:MGI:2154049]|Heterozygous|Homozygous mutant mice display male and female infertility, abnormal male and female meiosis, and arrest of spematogenesis.|T|C|149|37.0|Non-synonymous|Unprocessed|APF-G1
1561098|IGL00736|17|65864723|Y->C||1.0|Probably damaging||deleterious|MGI:108466|Ralbp1|ralA binding protein 1 [Source:MGI Symbol;Acc:MGI:108466]|Heterozygous|Homozygous and heterozygous null mice display increased sensitivity to X-ray irradiation, increased oxidative stress, and impaired glutathione homeostasis.|T|C|142|37.0|Non-synonymous|Unprocessed|APF-G1
1561099|IGL00736|14|56903211|V->A|||Benign|0.12|tolerated|MGI:1923257|Zmym2|zinc finger, MYM-type 2 [Source:MGI Symbol;Acc:MGI:1923257]|Heterozygous||T|C|92|36.5|Non-synonymous|Unprocessed|APF-G1
1561100|IGL00736|18|57292710|R->Q||0.36|Benign|0.29|tolerated|MGI:2685177|Megf10|multiple EGF-like-domains 10 [Source:MGI Symbol;Acc:MGI:2685177]|Heterozygous||G|A|62|35.0|Non-synonymous|Unprocessed|APF-G1
1561101|IGL00736|15|81407573|I->F||0.91|Possibly damaging|0.06|tolerated|MGI:1914012, MGI:2445217|Xpnpep3,dnajb7|DnaJ (Hsp40) homolog, subfamily B, member 7 [Source:MGI Symbol;Acc:MGI:1914012],X-prolyl aminopeptidase (aminopeptidase P) 3, putative [Source:MGI Symbol;Acc:MGI:2445217]|Heterozygous||T|A|44|38.5|Non-synonymous|Unprocessed|APF-G1
1561102|IGL00736|5|105607114|V->M||1.0|Probably damaging||deleterious|MGI:2140839|Lrrc8c|leucine rich repeat containing 8 family, member C [Source:MGI Symbol;Acc:MGI:2140839]|Heterozygous||G|A|42|36.0|Non-synonymous|Unprocessed|APF-G1
1561103|IGL00736|19|7790162|Q->R||0.62|Possibly damaging|0.03|deleterious|MGI:2385316|Bc014805|cDNA sequence BC014805 [Source:MGI Symbol;Acc:MGI:2385316]|Heterozygous||T|C|37|38.0|Non-synonymous|Unprocessed|APF-G1
1561104|IGL00736|3|75267809|M->I||1.0|Probably damaging|0.02|deleterious|MGI:1915181|Serpini2|serine (or cysteine) peptidase inhibitor, clade I, member 2 [Source:MGI Symbol;Acc:MGI:1915181]|Heterozygous||C|T|36|37.0|Non-synonymous|Unprocessed|APF-G1
1561105|IGL00736|9|63139538|Q->H||1.0|Probably damaging||deleterious|MGI:2443473|Skor1|SKI family transcriptional corepressor 1 [Source:MGI Symbol;Acc:MGI:2443473]|Heterozygous||C|A|27|35.0|Non-synonymous|Unprocessed|APF-G1
1561106|IGL00736|10|77322490|L->P||1.0|Probably damaging|0.21|tolerated|MGI:891999|Adarb1|adenosine deaminase, RNA-specific, B1 [Source:MGI Symbol;Acc:MGI:891999]|Heterozygous|Homozygous mutation of this gene results in progressive seizure susceptibility and death within 20 days of age. Mice homozygous for a conditional allele activated in neurons exhibit motor neuron degeneration, motor function abnormalities, and premature death.|A|G|22|31.0|Non-synonymous|Unprocessed|APF-G1
1561107|IGL00736|7|29312908|K->Stop|||N/A|||MGI:1352748|Dpf1|D4, zinc and double PHD fingers family 1 [Source:MGI Symbol;Acc:MGI:1352748]|Heterozygous||A|T|22|33.0|Non-synonymous|Unprocessed|APF-G1
1561108|IGL00736|12|78884837|L->Q|||Unknown||deleterious|MGI:95299|Eif2s1|eukaryotic translation initiation factor 2, subunit 1 alpha [Source:MGI Symbol;Acc:MGI:95299]|Heterozygous|Mice homozygous for a knocked-in point mutation die within hours of birth and exhibit hypoglycemia.|T|A|21|36.0|Non-synonymous|Unprocessed|APF-G1
1561109|IGL00736|7|118698702|E->G||1.0|Probably damaging||deleterious|MGI:1891827|Gde1|glycerophosphodiester phosphodiesterase 1 [Source:MGI Symbol;Acc:MGI:1891827]|Heterozygous||T|C|20|37.0|Non-synonymous|Unprocessed|APF-G1
1561110|IGL00736|5|135240032|Y->C||1.0|Probably damaging|0.01|deleterious|MGI:1353499|Baz1b|bromodomain adjacent to zinc finger domain, 1B [Source:MGI Symbol;Acc:MGI:1353499]|Heterozygous|Mice homozygous for a null allele exhibit postnatal lethality by P2, small size at birth, impaired double strand DNA repair, and heart defects. Mice heterozygous for a null allele exhibit hypercalcemia and heart defects.  Mice homozygous for an ENU mutation exhibit craniofacial and skeletal defects.|A|G|17|35.0|Non-synonymous|Unprocessed|APF-G1
1561111|IGL00736|15|12833959|Y->N|||Unknown||deleterious|MGI:1261425|Drosha|drosha, ribonuclease type III [Source:MGI Symbol;Acc:MGI:1261425]|Heterozygous||T|A|16|35.0|Non-synonymous|Unprocessed|APF-G1
1561112|IGL00736|2|70105645|Disrupted splicing|||N/A|||MGI:2448580|Myo3b|myosin IIIB [Source:MGI Symbol;Acc:MGI:2448580]|Heterozygous||A|C|24|35.0|Splice|Unprocessed|APF-G1
1561550|IGL00737|14|56584163|T->A||0.94|Possibly damaging|0.03|deleterious|MGI:2685589|Parp4|poly (ADP-ribose) polymerase family, member 4 [Source:MGI Symbol;Acc:MGI:2685589]|Heterozygous||A|G|210|35.0|Non-synonymous|Unprocessed|APF-G1
1561551|IGL00737|1|43100858|H->Q||0.34|Benign|0.61|tolerated|MGI:2138299|Ai597479|expressed sequence AI597479 [Source:MGI Symbol;Acc:MGI:2138299]|Heterozygous||T|G|91|35.0|Non-synonymous|Unprocessed|APF-G1
1561552|IGL00737|1|163797270|I->F||1.0|Probably damaging|0.01|deleterious|MGI:107566|Kifap3|kinesin-associated protein 3 [Source:MGI Symbol;Acc:MGI:107566]|Heterozygous|About 70% of homozygotes for a knock-out mutation die of heart failure shortly after birth due to massive cardiomyocyte apoptosis triggered by cardiovascular overload. Neonatal thymocytes and developing neuronal cells undergo apoptosis while cultured thymocytes are susceptible to apoptotic inducers.|A|T|79|37.0|Non-synonymous|Unprocessed|APF-G1
1561553|IGL00737|9|78435488|P->L||1.0|Probably damaging|0.02|deleterious|MGI:2442261|E330016a19rik|RIKEN cDNA E330016A19 gene [Source:MGI Symbol;Acc:MGI:2442261]|Heterozygous||G|A|77|37.0|Non-synonymous|Unprocessed|APF-G1
1561554|IGL00737|2|25584120|K->E|||Unknown|0.03|deleterious|MGI:2442633|B230208h17rik|RIKEN cDNA B230208H17 gene [Source:MGI Symbol;Acc:MGI:2442633]|Heterozygous||T|C|69|37.0|Non-synonymous|Unprocessed|APF-G1
1561555|IGL00737|12|8733381|Y->C||1.0|Probably damaging||deleterious|MGI:1931751|Pum2|pumilio 2 (Drosophila) [Source:MGI Symbol;Acc:MGI:1931751]|Heterozygous|Mice homozygous for a gene trapped allele exhibit significantly smaller testes and seminiferous tubule degeneration but are otherwise viable and fertile.|A|G|67|36.0|Non-synonymous|Unprocessed|APF-G1
1561556|IGL00737|12|101983466|V->A||1.0|Probably damaging||deleterious|MGI:1861601|Cpsf2|cleavage and polyadenylation specific factor 2 [Source:MGI Symbol;Acc:MGI:1861601]|Heterozygous||T|C|62|37.0|Non-synonymous|Unprocessed|APF-G1
1561557|IGL00737|16|52253180|L->Q|||Unknown||deleterious|MGI:1313266|Alcam|activated leukocyte cell adhesion molecule [Source:MGI Symbol;Acc:MGI:1313266]|Heterozygous|Homozygous null mice display abnormal motor neuron and retinal ganglion cell morphology and retinal dysplasia.|A|T|61|37.0|Non-synonymous|Unprocessed|APF-G1
1561558|IGL00737|1|37895376|R->H||0.09|Benign|0.04|deleterious|MGI:1333820|Mrpl30|mitochondrial ribosomal protein L30 [Source:MGI Symbol;Acc:MGI:1333820]|Heterozygous||G|A|59|39.0|Non-synonymous|Unprocessed|APF-G1
1561559|IGL00737|8|92909206|D->G||1.0|Probably damaging|0.01|deleterious|MGI:3606214|Lpcat2|lysophosphatidylcholine acyltransferase 2 [Source:MGI Symbol;Acc:MGI:3606214]|Heterozygous||A|G|49|36.0|Non-synonymous|Unprocessed|APF-G1
1561560|IGL00737|18|31878116|W->R|||Unknown|||MGI:1921570|Wdr33|WD repeat domain 33 [Source:MGI Symbol;Acc:MGI:1921570]|Heterozygous||T|A|43|38.0|Non-synonymous|Unprocessed|APF-G1
1561561|IGL00737|19|41552700|T->A||0.63|Possibly damaging|0.02|deleterious|MGI:2443930|Lcor|ligand dependent nuclear receptor corepressor [Source:MGI Symbol;Acc:MGI:2443930]|Heterozygous||A|G|40|34.5|Non-synonymous|Unprocessed|APF-G1
1561562|IGL00737|8|111458736|N->S||0.87|Possibly damaging|0.34|tolerated|MGI:2442115|Wdr59|WD repeat domain 59 [Source:MGI Symbol;Acc:MGI:2442115]|Heterozygous||T|C|32|35.5|Non-synonymous|Unprocessed|APF-G1
1561563|IGL00737|19|25182976|T->A|||Benign|1.0|tolerated|MGI:1921396|Dock8|dedicator of cytokinesis 8 [Source:MGI Symbol;Acc:MGI:1921396]|Heterozygous|Mice homozygous for inactivating mutations of this gene exhibit loss of marginal zone B cells, decrease in peritoneal B1 cells and peripheral naive T cells, failure of sustained antibody response after immunization, failure of germinal center persistence, and failure of B cell affinity maturation.|A|G|30|33.5|Non-synonymous|Unprocessed|APF-G1
1561564|IGL00737|1|172074401|Y->H||0.13|Benign|0.22|tolerated|MGI:1891700|Ncstn|nicastrin [Source:MGI Symbol;Acc:MGI:1891700]|Heterozygous|Homozygous mutant embryos die exhibiting morphological defects of the somites, yolk sac vasculature, neural tube, and pericardial sacs.|A|G|27|35.0|Non-synonymous|Unprocessed|APF-G1
1561565|IGL00737|6|71373707|V->A||0.06|Benign|0.6|tolerated|MGI:88346|Cd8a|CD8 antigen, alpha chain [Source:MGI Symbol;Acc:MGI:88346]|Heterozygous|Animals homozygous for a mutation in this gene lack CD8+CD4- cytotoxic T cells in the thymus and spleen and do not mount a cytotoxic response to alloantigens.|T|C|27|32.0|Non-synonymous|Unprocessed|APF-G1
1561566|IGL00737|5|142666870|D->E|||Benign|1.0|tolerated|MGI:1923831|Wipi2|WD repeat domain, phosphoinositide interacting 2 [Source:MGI Symbol;Acc:MGI:1923831]|Heterozygous||T|A|26|34.0|Non-synonymous|Unprocessed|APF-G1
1561567|IGL00737|13|92521118|K->Stop|||N/A|||MGI:2145181|Zfyve16|zinc finger, FYVE domain containing 16 [Source:MGI Symbol;Acc:MGI:2145181]|Heterozygous||T|A|24|36.0|Non-synonymous|Unprocessed|APF-G1
1561568|IGL00737|7|6393430|V->A||0.68|Possibly damaging|0.54|tolerated|MGI:99175|Zfp28|zinc finger protein 28 [Source:MGI Symbol;Acc:MGI:99175]|Heterozygous||T|C|23|31.0|Non-synonymous|Unprocessed|APF-G1
1561569|IGL00737|10|85143040|N->D|||Benign|0.71|tolerated|MGI:1270841|Cry1|cryptochrome 1 (photolyase-like) [Source:MGI Symbol;Acc:MGI:1270841]|Heterozygous|Homozygotes for targeted null mutations exhibit a one-hour shorter circadian period under constant darkness and reduced expression of another circadian gene in the suprachiasmatic nucleus in response to acute light exposure.|T|C|18|38.0|Non-synonymous|Unprocessed|APF-G1
1561570|IGL00737|1|194746239|Disrupted splicing|||N/A|||MGI:107684|Plxna2|plexin A2 [Source:MGI Symbol;Acc:MGI:107684]|Heterozygous|Mice homozygous for a knock-out allele show abnormal granule cell migration in the adult cerebellum and aberrant projection of mossy fibers in hippocampal slices. Mice homozygous for an ENU-induced allele are smaller and show granule cell migration defects and mild ataxia with incomplete penetrance.|G|A|43|38.0|Splice|Unprocessed|APF-G1
1561571|IGL00737|11|110196997|Disrupted splicing|||N/A|||MGI:1923434|Abca6|ATP-binding cassette, sub-family A (ABC1), member 6 [Source:MGI Symbol;Acc:MGI:1923434]|Heterozygous||A|T|35|39.0|Splice|Unprocessed|APF-G1
1562004|IGL00740|1|167316268|N->K||0.01|Benign|0.83|tolerated|MGI:1921173|Tmco1|transmembrane and coiled-coil domains 1 [Source:MGI Symbol;Acc:MGI:1921173]|Heterozygous||C|A|540|38.0|Non-synonymous|Unprocessed|APF-G1
1562005|IGL00740|18|49917668|D->E||0.97|Probably damaging|0.19|tolerated|MGI:2443926|Dmxl1|Dmx-like 1 [Source:MGI Symbol;Acc:MGI:2443926]|Heterozygous||T|G|201|37.0|Non-synonymous|Unprocessed|APF-G1
1562006|IGL00740|4|19280956|K->N||0.99|Probably damaging||deleterious|MGI:1353562|Cngb3|cyclic nucleotide gated channel beta 3 [Source:MGI Symbol;Acc:MGI:1353562]|Heterozygous|Mice homozygous for a knock-out allele exhibit cone degeneration and decreased photopic response.|A|T|66|35.5|Non-synonymous|Unprocessed|APF-G1
1562007|IGL00740|7|141855598|Q->K||0.83|Possibly damaging||deleterious|MGI:1921430|Muc5b|mucin 5, subtype B, tracheobronchial [Source:MGI Symbol;Acc:MGI:1921430]|Heterozygous||C|A|65|34.0|Non-synonymous|Unprocessed|APF-G1
1562008|IGL00740|1|28778651|L->P|||Unknown|0.06|tolerated|MGI:2685443|Gm597|predicted gene 597 [Source:MGI Symbol;Acc:MGI:2685443]|Heterozygous||A|G|57|36.0|Non-synonymous|Unprocessed|APF-G1
1562009|IGL00740|13|23478485|I->V|||Benign|1.0|tolerated|MGI:3606486|Btn2a2|butyrophilin, subfamily 2, member A2 [Source:MGI Symbol;Acc:MGI:3606486]|Heterozygous||T|C|55|34.0|Non-synonymous|Unprocessed|APF-G1
1562010|IGL00740|5|129513233|Y->N|||N/A||deleterious|MGI:101760|Sfswap|splicing factor, suppressor of white-apricot homolog (Drosophila) [Source:MGI Symbol;Acc:MGI:101760]|Heterozygous||T|A|35|35.0|Non-synonymous|Unprocessed|APF-G1
1562011|IGL00740|12|100376213|A->V|||Benign|0.59|tolerated|MGI:2144724|Ttc7b|tetratricopeptide repeat domain 7B [Source:MGI Symbol;Acc:MGI:2144724]|Heterozygous||G|A|27|36.0|Non-synonymous|Unprocessed|APF-G1
1562012|IGL00740|10|75638048|M->K|||Benign|0.01|deleterious|MGI:1918983|Susd2|sushi domain containing 2 [Source:MGI Symbol;Acc:MGI:1918983]|Heterozygous||A|T|23|34.0|Non-synonymous|Unprocessed|APF-G1
1562013|IGL00740|7|17051916|Disrupted splicing|||N/A|||MGI:1859778|Hif3a|hypoxia inducible factor 3, alpha subunit [Source:MGI Symbol;Acc:MGI:1859778]|Heterozygous|Mice homozygous for a knock-out allele display impaired lung remodeling resulting in hypertrophy of the heart right ventricle and pulmonary hyperplasia.|A|T|33|35.0|Splice|Unprocessed|APF-G1
1562559|IGL00741|13|92524253|L->P||1.0|Probably damaging||deleterious|MGI:2145181|Zfyve16|zinc finger, FYVE domain containing 16 [Source:MGI Symbol;Acc:MGI:2145181]|Heterozygous||A|G|237|37.0|Non-synonymous|Unprocessed|APF-G1
1562560|IGL00741|6|142687230|V->G|||Benign|0.23|tolerated|MGI:1352630|Abcc9|ATP-binding cassette, sub-family C (CFTR/MRP), member 9 [Source:MGI Symbol;Acc:MGI:1352630]|Heterozygous|Mice homozygous for disruptions in this gene display lower serum glucose, enhanced insulin action, growth retardation, hypertension and spontaneous death starting at 6 weeks of age due to episodic coronary artery vasospasm.|A|C|132|35.0|Non-synonymous|Unprocessed|APF-G1
1562561|IGL00741|18|42568453|E->G||0.51|Possibly damaging|0.01|deleterious|MGI:1926421|Tcerg1|transcription elongation regulator 1 (CA150) [Source:MGI Symbol;Acc:MGI:1926421]|Heterozygous||A|G|115|36.0|Non-synonymous|Unprocessed|APF-G1
1562562|IGL00741|5|33669640|Y->C||1.0|Probably damaging||deleterious|MGI:1341163|Tacc3|transforming, acidic coiled-coil containing protein 3 [Source:MGI Symbol;Acc:MGI:1341163]|Heterozygous||A|G|111|34.0|Non-synonymous|Unprocessed|APF-G1
1562563|IGL00741|9|86522806|T->A||1.0|Probably damaging||deleterious|MGI:1289294|Dopey1|dopey family member 1 [Source:MGI Symbol;Acc:MGI:1289294]|Heterozygous||A|G|81|33.0|Non-synonymous|Unprocessed|APF-G1
1562564|IGL00741|4|8839454|V->A||1.0|Probably damaging||deleterious|MGI:2444748|Chd7|chromodomain helicase DNA binding protein 7 [Source:MGI Symbol;Acc:MGI:2444748]|Heterozygous|Heterozygotes for mutations of this gene exhibit a variety of combinations of hyperactivity, circling, head-bobbing, semicircular canal defects, hearing loss, reduced size, and tail-kink.|T|C|62|31.5|Non-synonymous|Unprocessed|APF-G1
1562565|IGL00741|16|38603001|V->A||0.89|Possibly damaging||deleterious|MGI:1333857|Arhgap31|Rho GTPase activating protein 31 [Source:MGI Symbol;Acc:MGI:1333857]|Heterozygous||A|G|30|31.5|Non-synonymous|Unprocessed|APF-G1
1562566|IGL00741|2|181153010|Q->R||0.98|Probably damaging|0.01|deleterious|MGI:1096317|Eef1a2|eukaryotic translation elongation factor 1 alpha 2 [Source:MGI Symbol;Acc:MGI:1096317]|Heterozygous|Homozygotes for a spontaneous mutation exhibit muscle wasting, lymphoid hypoplasia, lack of intestinal IgA plasma cells, cerebellar dysfunction, neurodegeneration, an age-dependent increase in chromosomal aberrations, and lethality around 28 days of age.|T|C|26|34.0|Non-synonymous|Unprocessed|APF-G1
1562567|IGL00741|4|86276948|V->A||0.97|Probably damaging|0.01|deleterious|MGI:1924989|Adamtsl1|ADAMTS-like 1 [Source:MGI Symbol;Acc:MGI:1924989]|Heterozygous||T|C|24|34.0|Non-synonymous|Unprocessed|APF-G1
1562568|IGL00741|2|102586621|S->R||0.66|Possibly damaging|0.28|tolerated|MGI:2445082|Pamr1|peptidase domain containing associated with muscle regeneration 1 [Source:MGI Symbol;Acc:MGI:2445082]|Heterozygous||A|C|18|37.5|Non-synonymous|Unprocessed|APF-G1
1562569|IGL00741|6|40964834|Disrupted splicing|||N/A|||MGI:1920876|1810009j06rik|RIKEN cDNA 1810009J06 gene [Source:MGI Symbol;Acc:MGI:1920876]|Heterozygous||T|A|101|37.0|Splice|Unprocessed|APF-G1
1562570|IGL00741|17|57220206|Disrupted splicing|||N/A|||MGI:88227|C3|complement component 3 [Source:MGI Symbol;Acc:MGI:88227]|Heterozygous|Homozygous mutant mice exhibit abnormal immune responses, including increased mortality upon bacterial infection and decreased inflammatory response.|A|G|82|35.0|Splice|Unprocessed|APF-G1
1562571|IGL00741|4|138996574|Disrupted splicing|||N/A|||MGI:1924306|Tmco4|transmembrane and coiled-coil domains 4 [Source:MGI Symbol;Acc:MGI:1924306]|Heterozygous||T|A|32|33.0|Splice|Unprocessed|APF-G1
1563346|IGL00653|8|86861726|S->G|||Benign|0.43|tolerated|MGI:2136825|N4bp1|NEDD4 binding protein 1 [Source:MGI Symbol;Acc:MGI:2136825]|Heterozygous||T|C|53|38.0|Non-synonymous|Unprocessed|APF-G1
1563347|IGL00653|5|104092922|G->D||0.08|Benign|0.9|tolerated|MGI:108110|Sparcl1|SPARC-like 1 [Source:MGI Symbol;Acc:MGI:108110]|Heterozygous|Mice homozygous for a targeted null mutation exhibit no discernable phenotype; mice are viable and fertile with normal histology and survival.|C|T|45|38.0|Non-synonymous|Unprocessed|APF-G1
1563348|IGL00653|8|104849736|Y->F||1.0|Probably damaging||deleterious|MGI:2385905|Ces2c|carboxylesterase 2C [Source:MGI Symbol;Acc:MGI:2385905]|Heterozygous||A|T|44|39.0|Non-synonymous|Unprocessed|APF-G1
1563349|IGL00653|7|51566513|S->P||0.95|Possibly damaging|0.01|deleterious|MGI:3576659|Ano5|anoctamin 5 [Source:MGI Symbol;Acc:MGI:3576659]|Heterozygous||T|C|42|39.0|Non-synonymous|Unprocessed|APF-G1
1563350|IGL00653|9|55859859|N->K||1.0|Probably damaging|0.07|tolerated|MGI:1925976|Scaper|S phase cyclin A-associated protein in the ER [Source:MGI Symbol;Acc:MGI:1925976]|Heterozygous||A|T|42|40.0|Non-synonymous|Unprocessed|APF-G1
1563351|IGL00653|11|82116602|L->F||1.0|Probably damaging||deleterious|MGI:101878|Ccl8|chemokine (C-C motif) ligand 8 [Source:MGI Symbol;Acc:MGI:101878]|Heterozygous|Some alleles of <A HREF=http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:108224>Ccl12</A> also affect expression of this gene.|C|T|24|40.5|Non-synonymous|Unprocessed|APF-G1
1563352|IGL00653|14|103143228|N->S||0.94|Possibly damaging|1.0|tolerated|MGI:2179432|Mycbp2|MYC binding protein 2 [Source:MGI Symbol;Acc:MGI:2179432]|Heterozygous|Mice homozygous for a targeted allele exhibit neonatal lethality, defective diaphragm innervation, abnormal brain morphology and defective axonal guidance.|T|C|19|38.0|Non-synonymous|Unprocessed|APF-G1
1563353|IGL00653|17|30930760|S->P||0.97|Probably damaging||deleterious|MGI:99571|Glp1r|glucagon-like peptide 1 receptor [Source:MGI Symbol;Acc:MGI:99571]|Heterozygous|Glucose tolerance and pancreatic secretion is impaired in homozygous null mice.|T|C|19|40.0|Non-synonymous|Unprocessed|APF-G1
1753125|IGL00763|1|116117677|I->T||0.18|Benign|0.15|tolerated|MGI:3643623|Cntnap5a|contactin associated protein-like 5A [Source:MGI Symbol;Acc:MGI:3643623]|Heterozygous||T|C|163|40.0|Non-synonymous|Unprocessed|APF-G1
1753126|IGL00763|7|6208500|Y->C||1.0|Probably damaging|0.01|deleterious|MGI:2663979|Galp|galanin-like peptide [Source:MGI Symbol;Acc:MGI:2663979]|Heterozygous|Mice homozygous for a knock-out allele exhibit resistance to diet induced obesity.|A|G|146|35.0|Non-synonymous|Unprocessed|APF-G1
1753127|IGL00763|10|58575715|F->Y||0.99|Probably damaging|0.23|tolerated|MGI:1923388|Ccdc138|coiled-coil domain containing 138 [Source:MGI Symbol;Acc:MGI:1923388]|Heterozygous||T|A|135|39.0|Non-synonymous|Unprocessed|APF-G1
1753128|IGL00763|13|73794082|N->I||0.99|Probably damaging|0.01|deleterious|MGI:1342283|Slc12a7|solute carrier family 12, member 7 [Source:MGI Symbol;Acc:MGI:1342283]|Heterozygous|Hearing is severely impaired in homozygous mutant mice, which also exhibit renal tubular acidosis.|A|T|100|38.0|Non-synonymous|Unprocessed|APF-G1
1753129|IGL00763|9|49028163|T->A|||Benign|0.47|tolerated|MGI:2442293|Usp28|ubiquitin specific peptidase 28 [Source:MGI Symbol;Acc:MGI:2442293]|Heterozygous||A|G|83|37.0|Non-synonymous|Unprocessed|APF-G1
1753130|IGL00763|16|48612326|Q->P||0.99|Probably damaging|0.01|deleterious|MGI:1316740|Morc1|microrchidia 1 [Source:MGI Symbol;Acc:MGI:1316740]|Heterozygous|Inactivation of this locus results in small testes and male sterility, the latter owing to meiotic arrest. Mutant females exhibited histologically normal ovaries and were fertile.|A|C|74|40.0|Non-synonymous|Unprocessed|APF-G1
1753131|IGL00763|1|157529257|T->A|||Benign|0.4|tolerated|MGI:2148802|Sec16b|SEC16 homolog B (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:2148802]|Heterozygous||A|G|66|37.0|Non-synonymous|Unprocessed|APF-G1
1753134|IGL00764|1|155940746|T->K||0.46|Possibly damaging|0.06|tolerated|MGI:1921331|Cep350|centrosomal protein 350 [Source:MGI Symbol;Acc:MGI:1921331]|Heterozygous||G|T|88|39.0|Non-synonymous|Unprocessed|APF-G1
1753135|IGL00764|7|79395912|M->V||0.96|Probably damaging||deleterious|MGI:2384790|Fanci|Fanconi anemia, complementation group I [Source:MGI Symbol;Acc:MGI:2384790]|Heterozygous||A|G|85|40.0|Non-synonymous|Unprocessed|APF-G1
1753136|IGL00764|19|37974923|C->S|||Benign|0.62|tolerated|MGI:1919192|Myof|myoferlin [Source:MGI Symbol;Acc:MGI:1919192]|Heterozygous||A|T|58|38.0|Non-synonymous|Unprocessed|APF-G1
1753137|IGL00764|7|7132684|K->N||1.0|Probably damaging||deleterious|MGI:1923623|Zfp773|zinc finger protein 773 [Source:MGI Symbol;Acc:MGI:1923623]|Heterozygous||T|G|55|39.0|Non-synonymous|Unprocessed|APF-G1
1753138|IGL00764|10|94043634|I->V||0.03|Benign|0.89|tolerated|MGI:1261419|Fgd6|FYVE, RhoGEF and PH domain containing 6 [Source:MGI Symbol;Acc:MGI:1261419]|Heterozygous||A|G|46|36.0|Non-synonymous|Unprocessed|APF-G1
1753139|IGL00764|6|73195620|N->S||0.01|Benign|0.76|tolerated|MGI:107744|Dnahc6|dynein, axonemal, heavy chain 6 [Source:MGI Symbol;Acc:MGI:107744]|Heterozygous||T|C|31|38.0|Non-synonymous|Unprocessed|APF-G1
1753140|IGL00764|X|78370019|Q->Stop|||N/A|||MGI:1922160|4930480e11rik|RIKEN cDNA 4930480E11 gene [Source:MGI Symbol;Acc:MGI:1922160]|Heterozygous||C|T|31|39.0|Non-synonymous|Unprocessed|APF-G1
1753141|IGL00764|X|48131154|V->A||0.04|Benign|0.12|tolerated|MGI:2180001|Xpnpep2|X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound [Source:MGI Symbol;Acc:MGI:2180001]|Heterozygous||T|C|29|38.0|Non-synonymous|Unprocessed|APF-G1
1753142|IGL00764|4|117066469|S->P|||Benign|0.25|tolerated|MGI:1313286|Eif2b3|eukaryotic translation initiation factor 2B, subunit 3 [Source:MGI Symbol;Acc:MGI:1313286]|Heterozygous||T|C|23|37.0|Non-synonymous|Unprocessed|APF-G1
1753143|IGL00764|6|3532177|Q->Stop|||N/A|||MGI:1920538|Ccdc132|coiled-coil domain containing 132 [Source:MGI Symbol;Acc:MGI:1920538]|Heterozygous||C|T|22|40.0|Non-synonymous|Unprocessed|APF-G1
1753144|IGL00764|2|174645908|E->G||0.76|Possibly damaging|0.69|tolerated|MGI:3641861|Zfp831|zinc finger protein 831 [Source:MGI Symbol;Acc:MGI:3641861]|Heterozygous||A|G|19|39.0|Non-synonymous|Unprocessed|APF-G1
1753145|IGL00764|13|49711827|I->T||0.08|Benign||deleterious|MGI:2145219|Iars|isoleucine-tRNA synthetase [Source:MGI Symbol;Acc:MGI:2145219]|Heterozygous||T|C|17|35.0|Non-synonymous|Unprocessed|APF-G1
1753146|IGL00764|17|14690252|D->E||1.0|Probably damaging||deleterious|MGI:98738|Thbs2|thrombospondin 2 [Source:MGI Symbol;Acc:MGI:98738]|Heterozygous|Mice homozygous for a knock-out allele display premature death, abnormal tails, marked structural and functional abnormalities in a variety of connective tissues including skin, tendon, bone, and blood vessels, accelerated wound healing, and enhanced susceptibility to experimental skin tumors.|G|T|17|37.0|Non-synonymous|Unprocessed|APF-G1
1753147|IGL00764|6|115967972|V->E||0.91|Possibly damaging|0.42|tolerated|MGI:2154244|Plxnd1|plexin D1 [Source:MGI Symbol;Acc:MGI:2154244]|Heterozygous|Homozygous null mice display neonatal lethality, thin-walled atria, and vascular abnormalities including abnormal branchial arch artery development, cardiac outflow tract abnormalities, and reduced vascular smooth muscle around some vessels.|A|T|17|34.0|Non-synonymous|Unprocessed|APF-G1
1753148|IGL00764|18|86498812|H->L||0.94|Possibly damaging|0.01|deleterious|MGI:2180216|Neto1|neuropilin (NRP) and tolloid (TLL)-like 1 [Source:MGI Symbol;Acc:MGI:2180216]|Heterozygous|Mice homozygous for a null allele exhibit depressed long term potentiation, reduced NMDAR excitatory postsynaptic potentiation, and decreased spartial learning and working memory.|A|T|16|39.5|Non-synonymous|Unprocessed|APF-G1
1753149|IGL00764|5|103597718|V->A||||0.01|deleterious|MGI:103293|Ptpn13|protein tyrosine phosphatase, non-receptor type 13 [Source:MGI Symbol;Acc:MGI:103293]|Heterozygous|Mice homozygous for a null allele exhibit abnormal T-helper cell differentiation.|T|C|16|35.5|Non-synonymous|Unprocessed|APF-G1
1753151|IGL00764|11|118096485|V->A||0.97|Probably damaging|0.01|deleterious|MGI:1917176|Dnahc17|dynein, axonemal, heavy chain 17 [Source:MGI Symbol;Acc:MGI:1917176]|Heterozygous||A|G|11|33.0|Non-synonymous|Unprocessed|APF-G1
1753157|IGL00764|10|92694974|Disrupted splicing||||||MGI:97293|Nedd1|neural precursor cell expressed, developmentally down-regulated gene 1 [Source:MGI Symbol;Acc:MGI:97293]|Heterozygous||A|T|41|39.0|Splice|Unprocessed|APF-G1
1753158|IGL00764|7|144896935|Disrupted splicing||||||MGI:1096383|Fgf15|fibroblast growth factor 15 [Source:MGI Symbol;Acc:MGI:1096383]|Heterozygous|Targeted inactivation of this gene leads to a severe underrepresentation of homozygotes at weaning as well as highly penetrant ventricular septal defects and malalignment of the aorta and pulmonary trunk. No abnormalities in otic induction or otic vesicle formation are observed.|A|G|12|35.0|Splice|Unprocessed|APF-G1
1753637|IGL00763|9|92484945|E->G||1.0|Probably damaging|0.01|deleterious|MGI:2143267|Plscr4|phospholipid scramblase 4 [Source:MGI Symbol;Acc:MGI:2143267]|Heterozygous||A|G|55|38.0|Non-synonymous|Unprocessed|APF-G1
1753638|IGL00763|5|98872379|R->S||0.48|Possibly damaging|0.62|tolerated|MGI:88179|Bmp3|bone morphogenetic protein 3 [Source:MGI Symbol;Acc:MGI:88179]|Heterozygous|Homozygous mutation of this gene results in increased bone density.|A|C|52|37.0|Non-synonymous|Unprocessed|APF-G1
1753639|IGL00763|1|149851325|D->G||0.99|Probably damaging|0.01|deleterious|MGI:1195256|Pla2g4a|phospholipase A2, group IVA (cytosolic, calcium-dependent) [Source:MGI Symbol;Acc:MGI:1195256]|Heterozygous|Mice homozygouse for disruptions in this gene display reduced allergic and autoimmune reactions.  They also display an increased incidence of insulin and reduced female reproductive performance.|T|C|51|38.0|Non-synonymous|Unprocessed|APF-G1
1753640|IGL00763|15|76633868|A->T||||0.04|deleterious|MGI:1919999|Tonsl|tonsoku-like, DNA repair protein [Source:MGI Symbol;Acc:MGI:1919999]|Heterozygous||C|T|50|35.0|Non-synonymous|Unprocessed|APF-G1
1753641|IGL00763|1|36779252|D->V||||0.01|deleterious|MGI:99613|Zap70|zeta-chain (TCR) associated protein kinase [Source:MGI Symbol;Acc:MGI:99613]|Heterozygous|Mutant mice show T cell defects. Null mutants lack alpha-beta T cells in the thymus and have fewer T cells in dendritic and intestinal epithelium. Spontaneous and knock-in missense mutations affect T cell receptor signaling, one of the former resulting in severe chronic arthritis.|A|T|48|35.5|Non-synonymous|Unprocessed|APF-G1
1753642|IGL00763|7|144899892|F->I||1.0|Probably damaging|0.04|deleterious|MGI:1096383|Fgf15|fibroblast growth factor 15 [Source:MGI Symbol;Acc:MGI:1096383]|Heterozygous|Targeted inactivation of this gene leads to a severe underrepresentation of homozygotes at weaning as well as highly penetrant ventricular septal defects and malalignment of the aorta and pulmonary trunk. No abnormalities in otic induction or otic vesicle formation are observed.|T|A|46|39.0|Non-synonymous|Unprocessed|APF-G1
1753643|IGL00763|11|114767168|V->I||0.02|Benign|0.94|tolerated|MGI:2447024|Kif19a|kinesin family member 19A [Source:MGI Symbol;Acc:MGI:2447024]|Heterozygous||G|A|45|37.0|Non-synonymous|Unprocessed|APF-G1
1753644|IGL00763|18|78192238|D->E||1.0|Probably damaging|0.04|deleterious|MGI:1351653|Slc14a2|solute carrier family 14 (urea transporter), member 2 [Source:MGI Symbol;Acc:MGI:1351653]|Heterozygous|Homozygous mice lacking the collecting duct specific isoforms display decreased urea permeability and urine osmolality and increased urine flow.|G|T|40|39.0|Non-synonymous|Unprocessed|APF-G1
1753646|IGL00763|11|117779046|L->P|||Benign|0.3|tolerated|MGI:1098686|Tmc6|transmembrane channel-like gene family 6 [Source:MGI Symbol;Acc:MGI:1098686]|Heterozygous||A|G|27|37.0|Non-synonymous|Unprocessed|APF-G1
1753647|IGL00763|2|181590151|F->I||0.99|Probably damaging||deleterious|MGI:2685478|Znf512b|zinc finger protein 512B [Source:MGI Symbol;Acc:MGI:2685478]|Heterozygous||A|T|27|39.0|Non-synonymous|Unprocessed|APF-G1
1753649|IGL00763|12|83539333|R->H||1.0|Probably damaging||deleterious|MGI:1921078|Dcaf4|DDB1 and CUL4 associated factor 4 [Source:MGI Symbol;Acc:MGI:1921078]|Heterozygous||G|A|25|38.0|Non-synonymous|Unprocessed|APF-G1
1753650|IGL00763|9|89971020|T->A||1.0|Probably damaging|0.04|deleterious|MGI:99694|Rasgrf1|RAS protein-specific guanine nucleotide-releasing factor 1 [Source:MGI Symbol;Acc:MGI:99694]|Heterozygous|Homozygotes for null mutations (and heterozygotes with a paternally inherited mutant allele) exhibit reduced postnatal growth, low insulin and IGF I levels, glucose intolerance, beta-cell hypoplasia, impaired long-term synaptic plasticity, and impaired hippocampal-dependent learning.|A|G|25|37.0|Non-synonymous|Unprocessed|APF-G1
1753651|IGL00763|2|132101500|A->E||0.01|Benign|0.24|tolerated|MGI:1859682|Slc23a2|solute carrier family 23 (nucleobase transporters), member 2 [Source:MGI Symbol;Acc:MGI:1859682]|Heterozygous|Mice homozygous for disruptions in this gene die within minutes of birth from respiratory distress.|G|T|22|37.0|Non-synonymous|Unprocessed|APF-G1
1753652|IGL00763|8|119494219|I->M|||Benign|0.51|tolerated|MGI:2685433|Slc38a8|solute carrier family 38, member 8 [Source:MGI Symbol;Acc:MGI:2685433]|Heterozygous||T|C|19|35.0|Non-synonymous|Unprocessed|APF-G1
1753653|IGL00763|11|69684710|D->G||0.03|Benign|0.12|tolerated|MGI:1916833, MGI:1196259, MGI:3845075|Tnfsf12,bc096441,tnfsf13|tumor necrosis factor (ligand) superfamily, member 13 [Source:MGI Symbol;Acc:MGI:1916833],tumor necrosis factor (ligand) superfamily, member 12 [Source:MGI Symbol;Acc:MGI:1196259],cDNA sequence BC096441 [Source:MGI Symbol;Acc:MGI:3845075]|Heterozygous|Homozygous null mice are viable and fertile. No apparent defects of the immune system have been reported.,NO_PHENOTYPE,Mice homozygous for disruptions in this gene have increased numbers of natural killer cells, particulalry in secondary lymph organs.  They display an enhanced inflammatory response, increased susceptibility to lipopolysaccharide, and increased tumor resistance.|T|C|16|39.0|Non-synonymous|Unprocessed|APF-G1
1753654|IGL00763|4|126165578|G->S|||Benign|1.0|tolerated|MGI:2442637|Thrap3|thyroid hormone receptor associated protein 3 [Source:MGI Symbol;Acc:MGI:2442637]|Heterozygous||C|T|10|39.0|Non-synonymous|Unprocessed|APF-G1
1753656|IGL00763|9|53160026|Disrupted splicing||||||MGI:1924841|Ddx10|DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 [Source:MGI Symbol;Acc:MGI:1924841]|Heterozygous||A|C|662|35.0|Splice|Unprocessed|APF-G1
1753657|IGL00763|12|31665532|Disrupted splicing||||||MGI:2145130|Cog5|component of oligomeric golgi complex 5 [Source:MGI Symbol;Acc:MGI:2145130]|Heterozygous||C|T|257|39.0|Splice|Unprocessed|APF-G1
1753658|IGL00763|14|62700865|Disrupted splicing||||||MGI:1202397|Ints6|integrator complex subunit 6 [Source:MGI Symbol;Acc:MGI:1202397]|Heterozygous||A|G|78|39.0|Splice|Unprocessed|APF-G1
1753659|IGL00763|6|118418402|Disrupted splicing||||||MGI:2446132|Bms1|BMS1 homolog, ribosome assembly protein (yeast) [Source:MGI Symbol;Acc:MGI:2446132]|Heterozygous||A|G|67|37.0|Splice|Unprocessed|APF-G1
1753660|IGL00763|16|36856287|Disrupted splicing||||||MGI:2443764|Iqcb1|IQ calmodulin-binding motif containing 1 [Source:MGI Symbol;Acc:MGI:2443764]|Heterozygous||A|T|48|38.0|Splice|Unprocessed|APF-G1
1753661|IGL00763|11|58612881|Disrupted splicing||||||MGI:1925604|2210407c18rik|RIKEN cDNA 2210407C18 gene [Source:MGI Symbol;Acc:MGI:1925604]|Heterozygous||T|G|39|39.0|Splice|Unprocessed|APF-G1
1753662|IGL00763|7|89869615|Disrupted splicing||||||MGI:1918134|Ccdc81|coiled-coil domain containing 81 [Source:MGI Symbol;Acc:MGI:1918134]|Heterozygous||T|C|23|35.0|Splice|Unprocessed|APF-G1
1754164|IGL00765|2|127829472|N->I||1.0|Probably damaging||deleterious|MGI:1100510|Bub1|budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1100510]|Heterozygous|Mice homozygous for a null mutation exhibit embryonic lethality prior to implantation.|T|A|148|40.0|Non-synonymous|Unprocessed|APF-G1
1754165|IGL00765|13|63848772|V->A||0.11|Benign|0.08|tolerated|MGI:1923501|0610007p08rik|RIKEN cDNA 0610007P08 gene [Source:MGI Symbol;Acc:MGI:1923501]|Heterozygous||T|C|144|38.0|Non-synonymous|Unprocessed|APF-G1
1754166|IGL00765|15|43278349|M->K||0.06|Benign|0.08|tolerated|MGI:99257|Eif3e|eukaryotic translation initiation factor 3, subunit E [Source:MGI Symbol;Acc:MGI:99257]|Heterozygous||A|T|106|40.0|Non-synonymous|Unprocessed|APF-G1
1754167|IGL00765|6|134541854|T->P||0.28|Benign|0.1|tolerated|MGI:1298218|Lrp6|low density lipoprotein receptor-related protein 6 [Source:MGI Symbol;Acc:MGI:1298218]|Heterozygous|Animals homozygous for this mutation exhibit partial embryonic lethality, growth retardation, crooked tail, abnormal vertebrae, small skull with occasional bent nose, absence of the third molars and small and/or unerupted lower incisors. Heterozygotes exhibit a crooked tail and abnormal vertebrae.|T|G|56|37.0|Non-synonymous|Unprocessed|APF-G1
1754168|IGL00765|7|92933099|S->P|||Benign|0.37|tolerated|MGI:1919711|Prcp|prolylcarboxypeptidase (angiotensinase C) [Source:MGI Symbol;Acc:MGI:1919711]|Heterozygous|Mice homozygous for a gene trap allele exhibit decreased body length, weight, and fat pads with resistance to diet-induced obesity.|T|C|45|39.0|Non-synonymous|Unprocessed|APF-G1
1754169|IGL00765|11|87078041|E->G||0.94|Possibly damaging|0.01|deleterious|MGI:1921383|1200011m11rik|RIKEN cDNA 1200011M11 gene [Source:MGI Symbol;Acc:MGI:1921383]|Heterozygous||T|C|44|40.0|Non-synonymous|Unprocessed|APF-G1
1754170|IGL00765|15|8153228|I->T|||Benign||deleterious|MGI:2181182|Nup155|nucleoporin 155 [Source:MGI Symbol;Acc:MGI:2181182]|Heterozygous|Mice homozygous for a gene trap allele die prior to E8.5.  Mice homozygous for a gene trap allele exhibit atria fibrillation associated with shortened action potential duration.|T|C|42|39.5|Non-synonymous|Unprocessed|APF-G1
1754171|IGL00765|1|62704251|S->Stop|||N/A|||MGI:1100492|Nrp2|neuropilin 2 [Source:MGI Symbol;Acc:MGI:1100492]|Heterozygous|Mice homozygous for a different gene trap allele exhibit partial prenatal lethality and abnormal nervous system morphology. Mice homozygous for a knock-out allele exhibit partial prenatal lethality, abnormal lymphangiogenesis, and seizure susceptibility.|C|A|40|36.0|Non-synonymous|Unprocessed|APF-G1
1754172|IGL00765|7|97535205|T->I||1.0|Probably damaging|0.01|deleterious|MGI:1917164|Ints4|integrator complex subunit 4 [Source:MGI Symbol;Acc:MGI:1917164]|Heterozygous||C|T|38|36.0|Non-synonymous|Unprocessed|APF-G1
1754173|IGL00765|2|59806301|M->L||0.04|Benign|0.15|tolerated|MGI:1914110|Tanc1|tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 [Source:MGI Symbol;Acc:MGI:1914110]|Heterozygous|Mice homozygous for a gene trap vector exhibit decreased spine density in the CA3 region and impaired spatial memory.|A|C|29|38.0|Non-synonymous|Unprocessed|APF-G1
1754174|IGL00765|7|107190139|V->A||0.99|Probably damaging|0.01|deleterious|MGI:1924108|Nlrp14|NLR family, pyrin domain containing 14 [Source:MGI Symbol;Acc:MGI:1924108]|Heterozygous||T|C|28|39.0|Non-synonymous|Unprocessed|APF-G1
1754175|IGL00765|15|78292716|S->P||0.61|Possibly damaging|0.14|tolerated|MGI:1339760|Csf2rb2|colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) [Source:MGI Symbol;Acc:MGI:1339760]|Heterozygous|Homozygotes for a targeted null mutation are apparently normal.|A|G|24|37.0|Non-synonymous|Unprocessed|APF-G1
1754176|IGL00765|17|7772693|S->P|||Unknown|0.35|tolerated|MGI:1915905|Fndc1|fibronectin type III domain containing 1 [Source:MGI Symbol;Acc:MGI:1915905]|Heterozygous||A|G|23|37.0|Non-synonymous|Unprocessed|APF-G1
1754177|IGL00765|5|105811952|T->I||0.02|Benign|0.19|tolerated|MGI:1922368|Lrrc8d|leucine rich repeat containing 8D [Source:MGI Symbol;Acc:MGI:1922368]|Heterozygous||C|T|20|34.0|Non-synonymous|Unprocessed|APF-G1
1754178|IGL00765|2|24980224|A->S||0.93|Possibly damaging|0.05|deleterious|MGI:2385325|Pnpla7|patatin-like phospholipase domain containing 7 [Source:MGI Symbol;Acc:MGI:2385325]|Heterozygous||G|T|16|36.5|Non-synonymous|Unprocessed|APF-G1
1754179|IGL00765|7|25714852|L->P||1.0|Probably damaging||deleterious|MGI:1196455|Ccdc97|coiled-coil domain containing 97 [Source:MGI Symbol;Acc:MGI:1196455]|Heterozygous||A|G|15|38.0|Non-synonymous|Unprocessed|APF-G1
1754180|IGL00765|16|14411508|T->I||0.9|Possibly damaging||deleterious|MGI:102676|Abcc1|ATP-binding cassette, sub-family C (CFTR/MRP), member 1 [Source:MGI Symbol;Acc:MGI:102676]|Heterozygous|Mice homozygous for targeted mutations that inactivate the gene have a reduced response to inflammatory stimulus, increased levels of glutathione due to impaired metabolism, and are hypersensitive to the anticancer drug etoposide.|C|T|14|32.0|Non-synonymous|Unprocessed|APF-G1
1754181|IGL00765|1|87195709|V->A||1.0|Probably damaging|0.51|tolerated|MGI:87893|Chrnd|cholinergic receptor, nicotinic, delta polypeptide [Source:MGI Symbol;Acc:MGI:87893]|Heterozygous||T|C|13|39.0|Non-synonymous|Unprocessed|APF-G1
1754185|IGL00765|8|104517950|Disrupted splicing||||||MGI:2384561|Nae1|NEDD8 activating enzyme E1 subunit 1 [Source:MGI Symbol;Acc:MGI:2384561]|Heterozygous||T|C|104|40.0|Splice|Unprocessed|APF-G1
1754186|IGL00765|13|98850104|Disrupted splicing||||||MGI:2681523|Tnpo1|transportin 1 [Source:MGI Symbol;Acc:MGI:2681523]|Heterozygous||A|G|35|35.0|Splice|Unprocessed|APF-G1
1754187|IGL00765|5|34877425|Disrupted splicing||||||MGI:96285|Htt|huntingtin [Source:MGI Symbol;Acc:MGI:96067]|Heterozygous|Null mutants gastrulate abnormally and die in utero. Conditional mutants are small with progressive neurodegeneration. Knock-ins of 20-150 CAG repeat units variably mimic Huntington's with late-onset motor defects, reactive gliosis and neuronal inclusions.|T|C|28|38.5|Splice|Unprocessed|APF-G1
1754188|IGL00765|9|54415422|Disrupted splicing||||||MGI:2444630|Dmxl2|Dmx-like 2 [Source:MGI Symbol;Acc:MGI:2444630]|Heterozygous||A|G|22|39.0|Splice|Unprocessed|APF-G1
1754189|IGL00765|2|152330954|Disrupted splicing||||||MGI:1344372|Rbck1|RanBP-type and C3HC4-type zinc finger containing 1 [Source:MGI Symbol;Acc:MGI:1344372]|Heterozygous|Mice homozygous for a knock-out allele exhibit increased TNF-induced hepatocyte apoptosis.|A|G|11|36.0|Splice|Unprocessed|APF-G1
1754669|IGL00766|11|30950623|K->Stop|||N/A|||MGI:1914003|Erlec1|endoplasmic reticulum lectin 1 [Source:MGI Symbol;Acc:MGI:1914003]|Heterozygous||T|A|143|40.0|Non-synonymous|Unprocessed|APF-G1
1754670|IGL00766|3|69037379|D->E|||Benign|0.81|tolerated|MGI:1914199|Trim59|tripartite motif-containing 59 [Source:MGI Symbol;Acc:MGI:1914199]|Heterozygous||A|C|105|38.0|Non-synonymous|Unprocessed|APF-G1
1754671|IGL00766|15|8252164|Q->L||0.05|Benign|0.73|tolerated|MGI:1920942|2410089e03rik|RIKEN cDNA 2410089E03 gene [Source:MGI Symbol;Acc:MGI:1920942]|Heterozygous||A|T|66|40.0|Non-synonymous|Unprocessed|APF-G1
1754672|IGL00766|11|46469546|V->A||0.98|Probably damaging|0.17|tolerated|MGI:2159682|Havcr2|hepatitis A virus cellular receptor 2 [Source:MGI Symbol;Acc:MGI:2159682]|Heterozygous||T|C|60|38.0|Non-synonymous|Unprocessed|APF-G1
1754673|IGL00766|13|56630595|D->G||0.61|Possibly damaging|0.04|deleterious|MGI:99959|Tgfbi|transforming growth factor, beta induced [Source:MGI Symbol;Acc:MGI:99959]|Heterozygous|Mice homozygous for a knock-out allele exhibit postnatal growth retardation with increased incidence of tumors and chemically-induced tumors.|A|G|56|37.0|Non-synonymous|Unprocessed|APF-G1
1754674|IGL00766|1|188995776|V->I||0.41|Benign|0.03|deleterious|MGI:2444629|Kctd3|potassium channel tetramerisation domain containing 3 [Source:MGI Symbol;Acc:MGI:2444629]|Heterozygous||C|T|52|39.0|Non-synonymous|Unprocessed|APF-G1
1754675|IGL00766|3|95765379|V->A||0.02|Benign|0.02|deleterious|MGI:1922387|Rprd2|regulation of nuclear pre-mRNA domain containing 2 [Source:MGI Symbol;Acc:MGI:1922387]|Heterozygous||A|G|52|38.0|Non-synonymous|Unprocessed|APF-G1
1754676|IGL00766|19|12651262|D->E||0.12|Benign|0.08|tolerated|MGI:2147502|Glyat|glycine-N-acyltransferase [Source:MGI Symbol;Acc:MGI:2147502]|Heterozygous||T|G|50|39.0|Non-synonymous|Unprocessed|APF-G1
1754677|IGL00766|6|126013253|D->V||1.0|Probably damaging||deleterious|MGI:2387214|Ano2|anoctamin 2 [Source:MGI Symbol;Acc:MGI:2387214]|Heterozygous|Mice homozygous for a knock-out allele lack calcium-activated chloride currents in the main olfactory epithelium and vomeronasal organ but normal olfaction in behavioral tasks.|A|T|46|40.0|Non-synonymous|Unprocessed|APF-G1
1754678|IGL00766|6|141547883|Y->H||1.0|Probably damaging||deleterious|MGI:1889679|Slco1c1|solute carrier organic anion transporter family, member 1c1 [Source:MGI Symbol;Acc:MGI:1889679]|Heterozygous||T|C|42|37.0|Non-synonymous|Unprocessed|APF-G1
1754679|IGL00766|11|29501046|H->Q||0.93|Possibly damaging|0.68|tolerated|MGI:1925177|Ccdc88a|coiled coil domain containing 88A [Source:MGI Symbol;Acc:MGI:1925177]|Heterozygous|Mice homozygous for a knock-out allele exhibit postnatal weight loss, reduced angiogenesis, and premature death by P25.|T|A|41|38.0|Non-synonymous|Unprocessed|APF-G1
1754680|IGL00766|X|112405769|K->E||0.79|Possibly damaging|0.17|tolerated|MGI:1921059|Satl1|spermidine/spermine N1-acetyl transferase-like 1 [Source:MGI Symbol;Acc:MGI:1921059]|Heterozygous||T|C|40|37.5|Non-synonymous|Unprocessed|APF-G1
1754681|IGL00766|1|10199787|V->A|||Benign|0.88|tolerated|MGI:2442988|Arfgef1|ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited) [Source:MGI Symbol;Acc:MGI:2442988]|Heterozygous||A|G|36|38.0|Non-synonymous|Unprocessed|APF-G1
1754682|IGL00766|16|44729305|Q->Stop|||N/A|||MGI:2384836|Bc027231|cDNA sequence BC027231 [Source:MGI Symbol;Acc:MGI:2384836]|Heterozygous||C|T|36|40.0|Non-synonymous|Unprocessed|APF-G1
1754683|IGL00766|3|68914653|Y->Stop|||N/A|||MGI:1915509|Ift80|intraflagellar transport 80 homolog (Chlamydomonas) [Source:MGI Symbol;Acc:MGI:1915509]|Heterozygous|Mice homozygous for a hypomorphic gene trap allele exhibit partial perinatal lethality, decreased body size, postnatal growth retardation, shortened long bones, constricted thoracic cage, periaxial polydactyly, and small cranium.|A|T|32|30.0|Non-synonymous|Unprocessed|APF-G1
1754684|IGL00766|1|12820463|D->A||1.0|Probably damaging|0.04|deleterious|MGI:2138563|Sulf1|sulfatase 1 [Source:MGI Symbol;Acc:MGI:2138563]|Heterozygous|Mice homozygous for a null allele display a slight increase in mortality early in life.|A|C|31|39.0|Non-synonymous|Unprocessed|APF-G1
1754685|IGL00766|3|29657153|I->V||0.01|Benign|0.01|deleterious|MGI:1922990|Egfem1|EGF-like and EMI domain containing 1 [Source:MGI Symbol;Acc:MGI:1922990]|Heterozygous||A|G|31|37.0|Non-synonymous|Unprocessed|APF-G1
1754686|IGL00766|X|23906599|A->E|||Benign|0.73|tolerated|MGI:3648288|Gm4907|predicted gene 4907 [Source:MGI Symbol;Acc:MGI:3648288]|Heterozygous||C|A|30|38.0|Non-synonymous|Unprocessed|APF-G1
1754687|IGL00766|9|66450741|Y->C||1.0|Probably damaging|0.08|tolerated|MGI:2384589|Herc1|hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1 [Source:MGI Symbol;Acc:MGI:2384589]|Heterozygous|Homozygotes for this spontaneous mutation exhibit an abnormal cerebellar Purkinje cell layer and Purkinje cell degeneration.|A|G|29|38.0|Non-synonymous|Unprocessed|APF-G1
1754688|IGL00766|8|14975006|Y->C||1.0|Probably damaging|0.14|tolerated|MGI:2444453|Arhgef10|Rho guanine nucleotide exchange factor (GEF) 10 [Source:MGI Symbol;Acc:MGI:2444453]|Heterozygous||A|G|27|36.0|Non-synonymous|Unprocessed|APF-G1
1754689|IGL00766|7|104142824|Q->K|||Benign|1.0|tolerated|MGI:3045291|Ubqln3|ubiquilin 3 [Source:MGI Symbol;Acc:MGI:3045291]|Heterozygous||G|T|24|39.0|Non-synonymous|Unprocessed|APF-G1
1754690|IGL00766|14|20838567|N->S|||Benign|1.0|tolerated|MGI:97611|Plau|plasminogen activator, urokinase [Source:MGI Symbol;Acc:MGI:97611]|Heterozygous|Homozygotes show occasional fibrin deposits in non-healing ulcerations and reduced neointima formation after arterial injury.  They are susceptible to thrombosis after traumatic or inflammatory challenge and appear to be immunologically hyporesponsive displaying characteristics of functional anergy.|A|G|20|37.0|Non-synonymous|Unprocessed|APF-G1
1754691|IGL00766|8|70888537|I->S||1.0|Probably damaging||deleterious|MGI:2149330|Slc5a5|solute carrier family 5 (sodium iodide symporter), member 5 [Source:MGI Symbol;Acc:MGI:2149330]|Heterozygous||A|C|19|39.0|Non-synonymous|Unprocessed|APF-G1
1754692|IGL00766|10|128941854|D->Y||0.13|Benign|1.0|tolerated|MGI:102700|Itga7|integrin alpha 7 [Source:MGI Symbol;Acc:MGI:102700]|Heterozygous||G|T|18|34.5|Non-synonymous|Unprocessed|APF-G1
1754693|IGL00766|X|98803114|D->G||1.0|Probably damaging||deleterious|MGI:2151070|Ophn1|oligophrenin 1 [Source:MGI Symbol;Acc:MGI:2151070]|Heterozygous|Mice homozygous for a null allele exhibit some premature death, dilated lateral and third ventricle, abnormal dendrite morphology, and abnormal behavior including decreased anxiety and aggression and increased activity and exploration.|T|C|18|39.0|Non-synonymous|Unprocessed|APF-G1
1754694|IGL00766|15|96370405|R->C||0.07|Benign|0.02|deleterious|MGI:1924294|Arid2|AT rich interactive domain 2 (ARID, RFX-like) [Source:MGI Symbol;Acc:MGI:1924294]|Heterozygous||C|T|17|36.0|Non-synonymous|Unprocessed|APF-G1
1754695|IGL00766|4|139440766|D->G|||Unknown||deleterious|MGI:1916366|Ubr4|ubiquitin protein ligase E3 component n-recognin 4 [Source:MGI Symbol;Acc:MGI:1916366]|Heterozygous||A|G|17|38.0|Non-synonymous|Unprocessed|APF-G1
1754696|IGL00766|7|75704512|T->A||0.96|Probably damaging|0.05|tolerated|MGI:2676556|Akap13|A kinase (PRKA) anchor protein 13 [Source:MGI Symbol;Acc:MGI:2676556]|Heterozygous||A|G|17|38.0|Non-synonymous|Unprocessed|APF-G1
1754698|IGL00766|5|81794568|D->E||||0.12|tolerated|MGI:2441950|Lphn3|latrophilin 3 [Source:MGI Symbol;Acc:MGI:2441950]|Heterozygous||T|A|15|35.0|Non-synonymous|Unprocessed|APF-G1
1754699|IGL00766|5|53700036|R->L||0.99|Probably damaging|0.02|deleterious|MGI:99478|Cckar|cholecystokinin A receptor [Source:MGI Symbol;Acc:MGI:99478]|Heterozygous|Homozygous mutant mice cannot regulate core body temperature in response to changes in ambient temperature.|C|A|14|38.5|Non-synonymous|Unprocessed|APF-G1
1754700|IGL00766|15|37336301|F->L||1.0|Probably damaging||deleterious|MGI:2182543|Grhl2|grainyhead-like 2 (Drosophila) [Source:MGI Symbol;Acc:MGI:2182543]|Heterozygous|Mice homozygous for a null mutation display embryonic lethality during organogenesis with cranioschisis, facial cleft, impaired neural fold elevation, and an open posterior neuropore.|T|C|12|37.0|Non-synonymous|Unprocessed|APF-G1
1754702|IGL00766|3|123016544|Disrupted splicing||||||MGI:1913063|Myoz2|myozenin 2 [Source:MGI Symbol;Acc:MGI:1913063]|Heterozygous|Homozygous null mutants show an excess of skeletal muscle fibers and chronically activated hypertrophic gene program despite the absence of hypertrophy.  However, stressed null mutants do form cardiac hypertrophy.|G|A|53|37.0|Splice|Unprocessed|APF-G1
1754703|IGL00766|3|72907237|Disrupted splicing||||||MGI:97528|Sis|sucrase isomaltase (alpha-glucosidase) [Source:MGI Symbol;Acc:MGI:1917233]|Heterozygous||C|T|44|39.0|Splice|Unprocessed|APF-G1
1754704|IGL00766|10|105779582|Disrupted splicing||||||MGI:3041259|Bc067068|cDNA sequence BC067068 [Source:MGI Symbol;Acc:MGI:3041259]|Heterozygous||A|G|25|38.0|Splice|Unprocessed|APF-G1
1754705|IGL00766|13|94542884|Disrupted splicing||||||MGI:1333879|Ap3b1|adaptor-related protein complex 3, beta 1 subunit [Source:MGI Symbol;Acc:MGI:1333879]|Heterozygous|Homozygous mutants exhibit hypopigmentation, elevated kidney levels of lysosomal enzymes, platelet storage pool deficiency, reduced ipsilateral projections from the retina to brain, reduced sensitivity of dark-adapted retina and shortened life span.|G|T|15|39.0|Splice|Unprocessed|APF-G1
1755171|IGL00767|8|60896802|I->V|||Benign|1.0|tolerated|MGI:1919862|2700029m09rik|RIKEN cDNA 2700029M09 gene [Source:MGI Symbol;Acc:MGI:1919862]|Heterozygous||A|G|105|39.0|Non-synonymous|Unprocessed|APF-G1
1755172|IGL00767|4|16006377|H->Y||0.9|Possibly damaging|0.06|tolerated|MGI:2384798|Osgin2|oxidative stress induced growth inhibitor family member 2 [Source:MGI Symbol;Acc:MGI:2384798]|Heterozygous||G|A|49|40.0|Non-synonymous|Unprocessed|APF-G1
1755173|IGL00767|1|107536077|V->F||0.8|Possibly damaging|0.04|deleterious|MGI:3583100, MGI:3511869, MGI:3531331, MGI:3042878, MGI:3046813, MGI:3026891, MGI:2138648, MGI:3526906, MGI:3042876, MGI:2387105, MGI:2681004|Serpinb10-ps|serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 10, pseudogene [Source:MGI Symbol;Acc:MGI:2138648]|Heterozygous||G|T|38|40.0|Non-synonymous|Unprocessed|APF-G1
1755174|IGL00767|17|24106861|K->N||0.15|Benign|0.23|tolerated|MGI:1338068|Pdpk1|3-phosphoinositide dependent protein kinase 1 [Source:MGI Symbol;Acc:MGI:1338068]|Heterozygous|Homozygous mutant mice exhibit embryogenesis defects, impaired forebrain development, and die by mid gestation. Cardiac muscle-specific conditional mutants exhibit thin ventricular walls and die of heart failure.|T|G|37|37.0|Non-synonymous|Unprocessed|APF-G1
1755175|IGL00767|18|44276318|T->A|||Benign|1.0|tolerated|MGI:1098590|Npy6r|neuropeptide Y receptor Y6 [Source:MGI Symbol;Acc:MGI:1098590]|Heterozygous||A|G|36|35.5|Non-synonymous|Unprocessed|APF-G1
1755176|IGL00767|2|69175775|T->A||0.84|Possibly damaging|0.17|tolerated|MGI:3606242|Nostrin|nitric oxide synthase trafficker [Source:MGI Symbol;Acc:MGI:3606242]|Heterozygous||A|G|30|37.5|Non-synonymous|Unprocessed|APF-G1
1755177|IGL00767|7|79840890|S->A|||Benign|0.86|tolerated|MGI:5000466|Anpep|alanyl (membrane) aminopeptidase [Source:MGI Symbol;Acc:MGI:96749]|Heterozygous||A|C|25|37.0|Non-synonymous|Unprocessed|APF-G1
1755178|IGL00767|2|120745745|V->A|||Benign|1.0|tolerated|MGI:2155779|Ttbk2|tau tubulin kinase 2 [Source:MGI Symbol;Acc:MGI:2155779]|Heterozygous|Mice homozygous for a knock-in allele exhibit complete preweaning lethality, decreased embryo size, growth retardation, and incomplete turning.|A|G|18|30.0|Non-synonymous|Unprocessed|APF-G1
1755179|IGL00767|6|71903448|I->K||0.57|Possibly damaging|0.01|deleterious|MGI:1917206|Ptcd3|pentatricopeptide repeat domain 3 [Source:MGI Symbol;Acc:MGI:1917206]|Heterozygous||A|T|18|37.0|Non-synonymous|Unprocessed|APF-G1
1755180|IGL00767|8|64071321|R->C||1.0|Probably damaging|0.01|deleterious|MGI:106923|Tll1|tolloid-like [Source:MGI Symbol;Acc:MGI:106923]|Heterozygous|Homozygous null mice are embryonic lethal with death at midgestation from cardiac failure. Cardiac defects include incomplete formation of the ventricular septum and abnormal positioning of the heart and aorta.|G|A|18|36.5|Non-synonymous|Unprocessed|APF-G1
1755181|IGL00767|8|45896790|G->R||1.0|Probably damaging|0.13|tolerated|MGI:1859274|Pdlim3|PDZ and LIM domain 3 [Source:MGI Symbol;Acc:MGI:1859274]|Heterozygous|Homozygotes for a knock-out allele show no major defects in skeletal muscle. However, homozygotes for another knock-out allele show partial background-sensitive prenatal lethality, embryonic right ventricular (RV) dilation and dysplasia, hypotrabeculation, and RV cardiomyopathy in surviving adults.|G|A|16|39.5|Non-synonymous|Unprocessed|APF-G1
1755182|IGL00767|14|24165285|T->S||0.01|Benign|0.49|tolerated|MGI:1918478|Dlg5|discs, large homolog 5 (Drosophila) [Source:MGI Symbol;Acc:MGI:1918478]|Heterozygous|Mice homozygous for a null allele exhibit growth retardation, hydroencephaly, abnormal brain morphology, abnormal neurogenesis, kidney cysts, ureter defects, and abnormal kidney morphology.|T|A|14|37.5|Non-synonymous|Unprocessed|APF-G1
1755183|IGL00767|6|67303562|I->V||0.07|Benign|0.78|tolerated|MGI:1270861|Il12rb2|interleukin 12 receptor, beta 2 [Source:MGI Symbol;Acc:MGI:1270861]|Heterozygous|Mice homozygous for a knock-out allele have defects in IFN-gamma production and cytotoxic T lymphocyte and NK cytotoxicity, develop an autoimmune/lymphoproliferative disorder associated with higher susceptibility to spontaneous tumor formation, but show reduced in vivo growth of B16 melanoma tumors.|T|C|14|38.5|Non-synonymous|Unprocessed|APF-G1
1755185|IGL00767|7|79451925|P->S||1.0|Probably damaging|0.01|deleterious|MGI:1196389|Polg|polymerase (DNA directed), gamma [Source:MGI Symbol;Acc:MGI:1196389]|Heterozygous|Homozygous proof-reading deficient mutants display reduced life spans and premature aging with weight loss, decreased subcutaneous fat, alopecia, kyphosis, osteoporosis, anemia, reduced fertility, and enlarged hearts. Homozygous null mice display embryonic lethality.|G|A|13|37.0|Non-synonymous|Unprocessed|APF-G1
1755186|IGL00767|2|11488754|D->G||1.0|Probably damaging||deleterious|MGI:2181202|Pfkfb3|6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 [Source:MGI Symbol;Acc:MGI:2181202]|Heterozygous|Homozygous null mice display embryonic lethality before E8|T|C|12|37.5|Non-synonymous|Unprocessed|APF-G1
1755187|IGL00767|2|76885673|K->R|||Unknown|||MGI:98864|Ttn|titin [Source:MGI Symbol;Acc:MGI:98864]|Heterozygous|Homozygous mutant mice show embryogenesis defects in frontonasal mass, first branchial arch and somites, and vascular, cardiac and skeletal muscle defects causing growth retardation, muscle weakness, abnormal posture, and premature death ranging from embryonic day 11.5 to 8 weeks of age.|T|C|10|36.0|Non-synonymous|Unprocessed|APF-G1
1755191|IGL00767|9|70634003|Disrupted splicing||||||MGI:2443086|Fam63b|family with sequence similarity 63, member B [Source:MGI Symbol;Acc:MGI:2443086]|Heterozygous||A|G|124|39.0|Splice|Unprocessed|APF-G1
1755192|IGL00767|1|53764023|Disrupted splicing||||||MGI:2138162|Stk17b|serine/threonine kinase 17b (apoptosis-inducing) [Source:MGI Symbol;Acc:MGI:2138162]|Heterozygous|Homozygous null mice display abnormal T cell numbers, increased T cell proliferation, abnormal cytokine physiology, and decreased susceptibility to experimental autoimmune encephalomyelitis.|A|G|115|39.0|Splice|Unprocessed|APF-G1
1755193|IGL00767|6|149334750|Disrupted splicing||||||MGI:1914496|2810474o19rik|RIKEN cDNA 2810474O19 gene [Source:MGI Symbol;Acc:MGI:1914496]|Heterozygous||T|C|56|38.0|Splice|Unprocessed|APF-G1
1755194|IGL00767|10|86820273|Disrupted splicing||||||MGI:3513266|Nt5dc3|5'-nucleotidase domain containing 3 [Source:MGI Symbol;Acc:MGI:3513266]|Heterozygous||T|A|33|37.0|Splice|Unprocessed|APF-G1
1755195|IGL00767|14|78587261|Disrupted splicing||||||MGI:2444188|Dgkh|diacylglycerol kinase, eta [Source:MGI Symbol;Acc:MGI:2444188]|Heterozygous||T|A|16|39.0|Splice|Unprocessed|APF-G1
1755621|IGL00768|3|30895949|Y->N||0.98|Probably damaging|0.04|deleterious|MGI:1919112|Gpr160|G protein-coupled receptor 160 [Source:MGI Symbol;Acc:MGI:1919112]|Heterozygous||T|A|70|36.0|Non-synonymous|Unprocessed|APF-G1
1755622|IGL00768|X|127060743|Q->Stop|||N/A|||MGI:2685228|Gm382|predicted gene 382 [Source:MGI Symbol;Acc:MGI:2685228]|Heterozygous||C|T|59|39.0|Non-synonymous|Unprocessed|APF-G1
1755623|IGL00768|12|38427479|E->D|||Benign|0.49|tolerated|MGI:2442474|Dgkb|diacylglycerol kinase, beta [Source:MGI Symbol;Acc:MGI:2442474]|Heterozygous|Mice homozygous for a transposon distruption have defects in long term potentiation, synapase morphology, and in spatial reference and working memory.|A|C|56|38.0|Non-synonymous|Unprocessed|APF-G1
1755624|IGL00768|1|21384181|D->V||0.04|Benign|0.26|tolerated|MGI:2138477|Khdc1b|KH domain containing 1B [Source:MGI Symbol;Acc:MGI:2138477]|Heterozygous||A|T|44|37.5|Non-synonymous|Unprocessed|APF-G1
1755625|IGL00768|12|8002107|N->Y||1.0|Probably damaging||deleterious|MGI:88052|Apob|apolipoprotein B [Source:MGI Symbol;Acc:MGI:88052]|Heterozygous|Homozygous null mutants usually die by midgestation and longer survivors exhibit exencephaly. Heterozygotes show reduced plasma cholesterol and apolipoprotein levels. Single isoform B100 and B48 null mutants are viable.|A|T|38|38.0|Non-synonymous|Unprocessed|APF-G1
1755626|IGL00768|3|144755251|D->G||0.98|Probably damaging|0.01|deleterious|MGI:1316732|Clca1|chloride channel calcium activated 1 [Source:MGI Symbol;Acc:MGI:1316732]|Heterozygous||T|C|31|33.0|Non-synonymous|Unprocessed|APF-G1
1755627|IGL00768|9|3635111|V->A||||0.02|deleterious|MGI:2660877|Gucy1a2|guanylate cyclase 1, soluble, alpha 2 [Source:MGI Symbol;Acc:MGI:2660877]|Heterozygous|Mice homozygous for a null mutation display normal blood vessel and platelet physiology.|T|C|31|38.0|Non-synonymous|Unprocessed|APF-G1
1755628|IGL00768|5|108576654|H->Q|||Benign|0.84|tolerated|MGI:2442153|Gak|cyclin G associated kinase [Source:MGI Symbol;Acc:MGI:2442153]|Heterozygous||G|T|27|37.0|Non-synonymous|Unprocessed|APF-G1
1755629|IGL00768|9|105782412|S->G||0.04|Benign|0.01|deleterious|MGI:2444259|Col6a6|collagen, type VI, alpha 6 [Source:MGI Symbol;Acc:MGI:2444259]|Heterozygous||T|C|26|37.0|Non-synonymous|Unprocessed|APF-G1
1755630|IGL00768|14|118528997|V->I||0.01|Benign|0.15|tolerated|MGI:2443111|Abcc4|ATP-binding cassette, sub-family C (CFTR/MRP), member 4 [Source:MGI Symbol;Acc:MGI:2443111]|Heterozygous|Homozygous null mice are viable and fertile. Homozygotes for one null allele display impaired organic anion transport in the blood-brain and blood-cerebrospinal fliud barriers and kidney. Homozygotes for a second null allele display hypoalgesia and abnormal PGE2 physiology.|C|T|14|38.5|Non-synonymous|Unprocessed|APF-G1
1755631|IGL00768|X|72476297|H->R||0.98|Probably damaging|0.15|tolerated|MGI:95615|Gabra3|gamma-aminobutyric acid (GABA) A receptor, subunit alpha 3 [Source:MGI Symbol;Acc:MGI:95615]|Heterozygous|Hemizygous males exhibit hyperactivity and an increased startle response with impaired prepulse inhibition.|T|C|13|40.0|Non-synonymous|Unprocessed|APF-G1
1755633|IGL00768|10|91164206|Disrupted splicing||||||MGI:106920|Tmpo|thymopoietin [Source:MGI Symbol;Acc:MGI:106920]|Heterozygous|Mice homozygous null for a protein isoform generated from this locus have hyperproliferation of epidermal and erythroid progenitor cells that leads to thickened paws and increased crypt lengths in the colon.|G|A|84|39.0|Splice|Unprocessed|APF-G1
1755634|IGL00768|4|12055029|Disrupted splicing||||||MGI:1923928|Tmem67|transmembrane protein 67 [Source:MGI Symbol;Acc:MGI:1923928]|Heterozygous||A|G|21|37.0|Splice|Unprocessed|APF-G1
1755635|IGL00768|8|43140961|Disrupted splicing||||||MGI:2687279|Triml1|tripartite motif family-like 1 [Source:MGI Symbol;Acc:MGI:2687279]|Heterozygous||A|G|21|38.0|Splice|Unprocessed|APF-G1
1756112|IGL00769|2|54880104|E->K||0.08|Benign|0.32|tolerated|MGI:2139447|Galnt13|UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 [Source:MGI Symbol;Acc:MGI:2139447]|Heterozygous|Galnt13 is expressed exclusively in neuronal cells. Conditional animals can be used with cre-expressing strains to produce total or tissue-specific deletion of this locus.|G|A|122|34.0|Non-synonymous|Unprocessed|APF-G1
1756113|IGL00769|18|80912853|H->N||0.02|Benign||deleterious|MGI:1354757|Atp9b|ATPase, class II, type 9B [Source:MGI Symbol;Acc:MGI:1354757]|Heterozygous||G|T|86|39.0|Non-synonymous|Unprocessed|APF-G1
1756114|IGL00769|X|36004062|N->S||0.08|Benign|0.56|tolerated|MGI:1923224|Dock11|dedicator of cytokinesis 11 [Source:MGI Symbol;Acc:MGI:1923224]|Heterozygous||A|G|82|39.0|Non-synonymous|Unprocessed|APF-G1
1756115|IGL00769|5|88501484|Y->F||0.1|Benign|||MGI:1333772|Enam|enamelin [Source:MGI Symbol;Acc:MGI:1333772]|Heterozygous|Homozygous null mice lack true enamel due to loss of mineralization at the secretory surface of ameloblasts and mandibular incisors are opaque with a rough surface and abnormal wear on the incisal edge. ENU-induced mutant mice provide models for various clinical subtypes of amelogenesis imperfecta.|A|T|54|39.0|Non-synonymous|Unprocessed|APF-G1
1756117|IGL00769|15|18985099|P->Q||0.19|Benign|0.24|tolerated|MGI:107436|Cdh10|cadherin 10 [Source:MGI Symbol;Acc:MGI:107436]|Heterozygous||C|A|43|40.0|Non-synonymous|Unprocessed|APF-G1
1756118|IGL00769|17|18583819|V->M|||Benign|0.08|tolerated|MGI:3644514|Vmn2r96|vomeronasal 2, receptor 96 [Source:MGI Symbol;Acc:MGI:3644514]|Heterozygous||G|A|41|40.0|Non-synonymous|Unprocessed|APF-G1
1756119|IGL00769|10|18660604|S->P||0.01|Benign|0.29|tolerated|MGI:106387|D10bwg1379e|DNA segment, Chr 10, Brigham & Women's Genetics 1379 expressed [Source:MGI Symbol;Acc:MGI:106387]|Heterozygous||A|G|33|40.0|Non-synonymous|Unprocessed|APF-G1
1756120|IGL00769|4|63144165|T->I||1.0|Probably damaging|0.06|tolerated|MGI:88002|Ambp|alpha 1 microglobulin/bikunin [Source:MGI Symbol;Acc:MGI:88002]|Heterozygous|Female homozygotes for targeted null mutations exhibit reduced ovulation rates, oocytes lacking a zona pellucida, and a very low fertilization rate.|G|A|27|38.0|Non-synonymous|Unprocessed|APF-G1
1756121|IGL00769|4|141180449|T->M||1.0|Probably damaging|0.01|deleterious|MGI:1924992|Fbxo42|F-box protein 42 [Source:MGI Symbol;Acc:MGI:1924992]|Heterozygous||C|T|26|39.0|Non-synonymous|Unprocessed|APF-G1
1756122|IGL00769|1|88139050|P->S||1.0|Probably damaging|0.01|deleterious|MGI:3032636, MGI:2137698, MGI:3580642, MGI:3580629, MGI:3576092|Ugt1a6a,ugt1a10,ugt1a6b,ugt1a9,ugt1a7c|UDP glycosyltransferase 1 family, polypeptide A10 [Source:MGI Symbol;Acc:MGI:3580642],UDP glucuronosyltransferase 1 family, polypeptide A6A [Source:MGI Symbol;Acc:MGI:2137698],UDP glucuronosyltransferase 1 family, polypeptide A6B [Source:MGI Symbol;Acc:MGI:3580629],UDP glucuronosyltransferase 1 family, polypeptide A7C [Source:MGI Symbol;Acc:MGI:3032636],UDP glucuronosyltransferase 1 family, polypeptide A9 [Source:MGI Symbol;Acc:MGI:3576092]|Heterozygous||C|T|25|35.0|Non-synonymous|Unprocessed|APF-G1
1756123|IGL00769|14|31743365|V->A||0.09|Benign|0.55|tolerated|MGI:2145661|Ankrd28|ankyrin repeat domain 28 [Source:MGI Symbol;Acc:MGI:2145661]|Heterozygous||A|G|24|38.0|Non-synonymous|Unprocessed|APF-G1
1756124|IGL00769|4|116692965|D->N|||Benign|0.08|tolerated|MGI:99523|Prdx1|peroxiredoxin 1 [Source:MGI Symbol;Acc:MGI:99523]|Heterozygous|Mutant mice exhibit defects in antioxidant defense that manifest as hemolytic anemia and malignancies. The phenotype is more severe in homozygous mutant mice which die prematurely.|G|A|22|39.5|Non-synonymous|Unprocessed|APF-G1
1756125|IGL00769|9|15326144|S->P||0.85|Possibly damaging|0.08|tolerated|MGI:2442521|5830418k08rik|RIKEN cDNA 5830418K08 gene [Source:MGI Symbol;Acc:MGI:2442521]|Heterozygous||A|G|20|38.5|Non-synonymous|Unprocessed|APF-G1
1756126|IGL00769|18|59072277|S->P||0.44|Possibly damaging|0.06|tolerated|MGI:2442934|A730017c20rik|RIKEN cDNA A730017C20 gene [Source:MGI Symbol;Acc:MGI:2442934]|Heterozygous||T|C|19|38.0|Non-synonymous|Unprocessed|APF-G1
1756127|IGL00769|11|97771581|F->S||1.0|Probably damaging||deleterious|MGI:1919465|1700001p01rik|RIKEN cDNA 1700001P01 gene [Source:MGI Symbol;Acc:MGI:1919465]|Heterozygous||A|G|18|34.5|Non-synonymous|Unprocessed|APF-G1
1756128|IGL00769|16|32256497|W->Stop|||N/A|||MGI:1916230|Wdr53|WD repeat domain 53 [Source:MGI Symbol;Acc:MGI:1916230]|Heterozygous||G|A|17|37.0|Non-synonymous|Unprocessed|APF-G1
1756129|IGL00769|X|168668748|E->V||1.0|Probably damaging||deleterious|MGI:1341851|Msl3|male-specific lethal 3 homolog (Drosophila) [Source:MGI Symbol;Acc:MGI:1341851]|Heterozygous||T|A|15|37.0|Non-synonymous|Unprocessed|APF-G1
1756130|IGL00769|7|48198901|D->V|||Benign|0.5|tolerated|MGI:3033119|Mrgprb4|MAS-related GPR, member B4 [Source:MGI Symbol;Acc:MGI:3033119]|Heterozygous||T|A|14|37.5|Non-synonymous|Unprocessed|APF-G1
1756131|IGL00769|5|31553777|Y->D||1.0|Probably damaging||deleterious|MGI:1196608|Slc4a1ap|solute carrier family 4 (anion exchanger), member 1, adaptor protein [Source:MGI Symbol;Acc:MGI:1196608]|Heterozygous||T|G|13|39.0|Non-synonymous|Unprocessed|APF-G1
1756132|IGL00769|11|101434274|D->G||1.0|Probably damaging||deleterious|MGI:2144506|Rundc1|RUN domain containing 1 [Source:MGI Symbol;Acc:MGI:2144506]|Heterozygous||A|G|12|39.0|Non-synonymous|Unprocessed|APF-G1
1756133|IGL00769|7|131082500|S->R|||Unknown|0.36|tolerated|MGI:106210|Dmbt1|deleted in malignant brain tumors 1 [Source:MGI Symbol;Acc:MGI:106210]|Heterozygous|Mice homozygous for one null allele display embryonic lethality and an abnormal inner cell mass.  Mice homozygous for a different null allele are viable and fertile with an increased susceptibility to induced colitis.|T|A|12|38.0|Non-synonymous|Unprocessed|APF-G1
1756134|IGL00769|11|48948212|V->A||0.66|Possibly damaging|0.16|tolerated|MGI:3041173|9930111j21rik1|RIKEN cDNA 9930111J21 gene 1 [Source:MGI Symbol;Acc:MGI:3041173]|Heterozygous||A|G|11|32.0|Non-synonymous|Unprocessed|APF-G1
1756136|IGL00769|8|67908679|Disrupted splicing||||||MGI:1918215|Psd3|pleckstrin and Sec7 domain containing 3 [Source:MGI Symbol;Acc:MGI:1918215]|Heterozygous||A|T|34|36.5|Splice|Unprocessed|APF-G1
1756137|IGL00769|X|75334180|Disrupted splicing||||||MGI:88383|F8|coagulation factor VIII [Source:MGI Symbol;Acc:MGI:88383]|Heterozygous|Male hemizygotes and female homozygotes for targeted null mutations produce no factor VIII, but are apparently healthy and fertile. However, affected mice show prolonged, exsanguinating bleeding following tail-clipping.|A|T|30|37.0|Splice|Unprocessed|APF-G1
1756138|IGL00769|3|92014622|Disrupted splicing||||||MGI:2685266|Pglyrp3|peptidoglycan recognition protein 3 [Source:MGI Symbol;Acc:MGI:2685266]|Heterozygous||A|T|18|38.0|Splice|Unprocessed|APF-G1
1756590|IGL00770|4|11593765|R->K|||Benign|1.0|tolerated|MGI:3605986|Rad54b|RAD54 homolog B (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:3605986]|Heterozygous||G|A|253|39.0|Non-synonymous|Unprocessed|APF-G1
1756591|IGL00770|8|110817638|I->N||0.89|Possibly damaging|0.2|tolerated|MGI:1289341|Sf3b3|splicing factor 3b, subunit 3 [Source:MGI Symbol;Acc:MGI:1289341]|Heterozygous||A|T|140|38.0|Non-synonymous|Unprocessed|APF-G1
1756592|IGL00770|2|65735853|D->G||1.0|Probably damaging||deleterious|MGI:98248|Scn2a1|sodium channel, voltage-gated, type II, alpha 1 [Source:MGI Symbol;Acc:MGI:98248]|Heterozygous|Homozygotes for a targeted mutation exhibit excess neuronal apoptosis (especially in the brainstem), reduced neuronal sodium channel currents in vitro, and severe hypoxia resulting in neonatal lethality.|A|G|85|39.0|Non-synonymous|Unprocessed|APF-G1
1756593|IGL00770|3|27098443|R->W||1.0|Probably damaging||deleterious|MGI:95281|Ect2|ect2 oncogene [Source:MGI Symbol;Acc:MGI:95281]|Heterozygous|Homozygous disruption of this locus is embryonic lethal.|G|A|80|38.0|Non-synonymous|Unprocessed|APF-G1
1756594|IGL00770|12|30588721|R->G|||Unknown|0.09|tolerated|MGI:2387176|Tmem18|transmembrane protein 18 [Source:MGI Symbol;Acc:MGI:2387176]|Heterozygous||A|G|72|35.5|Non-synonymous|Unprocessed|APF-G1
1756595|IGL00770|15|38006541|T->A||0.27|Benign|0.28|tolerated|MGI:1918040|Ubr5|ubiquitin protein ligase E3 component n-recognin 5 [Source:MGI Symbol;Acc:MGI:1918040]|Heterozygous|Homozygous null mice display embryonic lethality during organogenesis, impaired growth of the allantois, failure or impairment of chorioallantoic fusion, impaired angiogenesis in the yolk sac and allantois, decreased cell proliferation, and increased apoptosis.|T|C|70|31.0|Non-synonymous|Unprocessed|APF-G1
1756596|IGL00770|2|28665011|H->L||0.87|Possibly damaging|0.03|deleterious|MGI:1929183|Tsc1|tuberous sclerosis 1 [Source:MGI Symbol;Acc:MGI:1929183]|Heterozygous|Homozygous null mutants show liver hypoplasia, open neural tube and die by embryonic day 10.5-11.5. Heterozygotes develop kidney cystadenomas and liver hemangiomas. Conditional astrocyte-specific nulls show increased astrocyte numbers and seizures.|A|T|54|38.0|Non-synonymous|Unprocessed|APF-G1
1756597|IGL00770|4|152052015|S->P||0.92|Possibly damaging|0.22|tolerated|MGI:1921285|Nol9|nucleolar protein 9 [Source:MGI Symbol;Acc:MGI:1921285]|Heterozygous||T|C|53|38.0|Non-synonymous|Unprocessed|APF-G1
1756598|IGL00770|1|105597756|V->A||||0.14|tolerated|MGI:1351629|Pign|phosphatidylinositol glycan anchor biosynthesis, class N [Source:MGI Symbol;Acc:MGI:1351629]|Heterozygous||A|G|48|38.0|Non-synonymous|Unprocessed|APF-G1
1756599|IGL00770|1|53320246|I->V||0.16|Benign|0.09|tolerated|MGI:1919335|Osgepl1|O-sialoglycoprotein endopeptidase-like 1 [Source:MGI Symbol;Acc:MGI:1919335]|Heterozygous||A|G|41|38.0|Non-synonymous|Unprocessed|APF-G1
1756600|IGL00770|12|4855303|E->G||1.0|Probably damaging|0.05|deleterious|MGI:3040699|Bc068281|cDNA sequence BC068281 [Source:MGI Symbol;Acc:MGI:3040699]|Heterozygous||A|G|37|39.0|Non-synonymous|Unprocessed|APF-G1
1756601|IGL00770|13|29918704|D->E||0.9|Possibly damaging|0.03|deleterious|MGI:1096340|E2f3|E2F transcription factor 3 [Source:MGI Symbol;Acc:MGI:1096340]|Heterozygous|Mice homozygous for a null allele exhibit increased lethality prior to adulthood but otherwise appear normal.  Mouse embryonic fibroblast cells from mice homozygous for a null allele are defective in cell cycle progression and exhibit reduced proliferation.|A|T|32|38.0|Non-synonymous|Unprocessed|APF-G1
1756602|IGL00770|4|49536843|S->P||0.1|Benign|0.12|tolerated|MGI:87995|Aldob|aldolase B, fructose-bisphosphate [Source:MGI Symbol;Acc:MGI:87995]|Heterozygous||A|G|32|37.5|Non-synonymous|Unprocessed|APF-G1
1756603|IGL00770|8|104292930|S->P||0.96|Probably damaging|0.38|tolerated|MGI:2447160|Cmtm2a|CKLF-like MARVEL transmembrane domain containing 2A [Source:MGI Symbol;Acc:MGI:2447160]|Heterozygous||A|G|27|38.0|Non-synonymous|Unprocessed|APF-G1
1756604|IGL00770|11|60205139|R->Q||0.46|Possibly damaging|0.01|deleterious|MGI:107606|Srebf1|sterol regulatory element binding transcription factor 1 [Source:MGI Symbol;Acc:MGI:107606]|Heterozygous|Mice homozygous for a knock-out allele of transcript A die between E11.5 and E14.5. Mice homozygous for a knock-out allele of transcript C exhibit decreased circulating triglyceride levels. Mice homozygous for a gene trap allele exhibit decreased hepatic triglyceride storage.|C|T|26|39.0|Non-synonymous|Unprocessed|APF-G1
1756605|IGL00770|4|86388539|A->T||0.34|Benign|0.47|tolerated|MGI:1924989|Adamtsl1|ADAMTS-like 1 [Source:MGI Symbol;Acc:MGI:1924989]|Heterozygous||G|A|25|34.0|Non-synonymous|Unprocessed|APF-G1
1756606|IGL00770|9|70631033|D->G||0.04|Benign|0.4|tolerated|MGI:2443086|Fam63b|family with sequence similarity 63, member B [Source:MGI Symbol;Acc:MGI:2443086]|Heterozygous||T|C|25|40.0|Non-synonymous|Unprocessed|APF-G1
1756607|IGL00770|10|109816263|D->G||0.02|Benign|0.34|tolerated|MGI:2183703|Nav3|neuron navigator 3 [Source:MGI Symbol;Acc:MGI:2183703]|Heterozygous||T|C|22|38.0|Non-synonymous|Unprocessed|APF-G1
1756608|IGL00770|15|54254072|R->S||0.55|Possibly damaging|0.02|deleterious|MGI:109587|Tnfrsf11b|tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) [Source:MGI Symbol;Acc:MGI:109587]|Heterozygous|Homozygote null mice have abnormal bone remodeling that results in severe osteoperosis with increased risk of fractures and growth retardation.  Progressive hearing loss also results due to abnormal remodeling of the otic capsule.|T|G|21|39.0|Non-synonymous|Unprocessed|APF-G1
1756609|IGL00770|18|32228239|P->L||0.04|Benign|0.21|tolerated|MGI:1346873|Map3k2|mitogen-activated protein kinase kinase kinase 2 [Source:MGI Symbol;Acc:MGI:1346873]|Heterozygous|Mice homozygous for disruptions in this gene are grossly normal and fertile.|C|T|10|38.0|Non-synonymous|Unprocessed|APF-G1
1756610|IGL00770|15|91801833|Disrupted splicing||||||MGI:1913975|Lrrk2|leucine-rich repeat kinase 2 [Source:MGI Symbol;Acc:MGI:1913975]|Heterozygous|Mice homozygous for a knock-in allele exhibit impaired response to dopamine, amphetamine, and quinpirole.  Mice homozygous for one knock-out allele exhibit increased neurite growth. Mice homozygous for different knock-out alleles exhibit alopecia due to excessive grooming or kdiney atrophy.|T|G|175|39.0|Splice|Unprocessed|APF-G1
1756611|IGL00770|13|61198339|Disrupted splicing||||||MGI:1889619|Cts6|cathepsin 6 [Source:MGI Symbol;Acc:MGI:1889619]|Heterozygous||T|C|91|38.0|Splice|Unprocessed|APF-G1
1756612|IGL00770|5|72108446|Disrupted splicing||||||MGI:95619|Gabrb1|gamma-aminobutyric acid (GABA) A receptor, subunit beta 1 [Source:MGI Symbol;Acc:MGI:95619]|Heterozygous||G|T|77|40.0|Splice|Unprocessed|APF-G1
1756613|IGL00770|12|108514515|Disrupted splicing||||||MGI:1915769|Eml1|echinoderm microtubule associated protein like 1 [Source:MGI Symbol;Acc:MGI:1915769]|Heterozygous||A|G|57|37.0|Splice|Unprocessed|APF-G1
1756614|IGL00770|X|17558013|Disrupted splicing||||||MGI:1919268|Fundc1|FUN14 domain containing 1 [Source:MGI Symbol;Acc:MGI:1919268]|Heterozygous||T|A|51|39.0|Splice|Unprocessed|APF-G1
1756615|IGL00770|9|21987722|Disrupted splicing||||||MGI:1918996|Rgl3|ral guanine nucleotide dissociation stimulator-like 3 [Source:MGI Symbol;Acc:MGI:1918996]|Heterozygous||A|T|44|37.5|Splice|Unprocessed|APF-G1
1756616|IGL00770|3|101283029|Disrupted splicing||||||MGI:88320|Cd2|CD2 antigen [Source:MGI Symbol;Acc:MGI:88320]|Heterozygous|Homozygous mutation of this gene does not appear to result in a phenotype.|A|T|23|37.0|Splice|Unprocessed|APF-G1
1757600|IGL00772|12|50383416|E->G||1.0|Probably damaging||deleterious|MGI:99879|Prkd1|protein kinase D1 [Source:MGI Symbol;Acc:MGI:99879]|Heterozygous|Mice homozygous for a knock-out allele exhibit embryonic lethality.|T|C|87|39.0|Non-synonymous|Unprocessed|APF-G1
1757601|IGL00772|18|44006420|I->V||0.01|Benign|1.0|tolerated|MGI:1919682|Spink5|serine peptidase inhibitor, Kazal type 5 [Source:MGI Symbol;Acc:MGI:1919682]|Heterozygous|Homozygous mutant mice display neonatal lethality, exfoliative erythroderma, and severe dehydration.|A|G|65|38.0|Non-synonymous|Unprocessed|APF-G1
1757602|IGL00772|1|110949252|D->G||0.99|Probably damaging|0.01|deleterious|MGI:3588198|Cdh19|cadherin 19, type 2 [Source:MGI Symbol;Acc:MGI:3588198]|Heterozygous||T|C|62|38.0|Non-synonymous|Unprocessed|APF-G1
1757603|IGL00772|X|150655325|V->A||0.05|Benign|0.04|deleterious|MGI:1928994|Tro|trophinin [Source:MGI Symbol;Acc:MGI:1928994]|Heterozygous|Homozygous female or hemizygous male mice on a mixed 129 and NIH black Swiss background are viable, fertile and elderly mice exhibit no disorders.  On an inbred 129 background, homozygous female or hemizygous male mice show partial embryonic lethality between E3.5 and E8.5.|A|G|57|39.0|Non-synonymous|Unprocessed|APF-G1
1757604|IGL00772|5|96636112|I->N||0.67|Possibly damaging|0.01|deleterious|MGI:2385368|Fras1|Fraser syndrome 1 homolog (human) [Source:MGI Symbol;Acc:MGI:2385368]|Heterozygous|Mice homozygous for mutations at this locus display a significant amount of embryonic lethality due to hemorrhaging of embryonic blisters.  Survival is variable on genetic backgrounds.  Kidney development is severely affected and syndactyly is common.|T|A|37|38.0|Non-synonymous|Unprocessed|APF-G1
1757605|IGL00772|1|65062091|R->Q||0.94|Possibly damaging|0.15|tolerated|MGI:88524|Crygd|crystallin, gamma D [Source:MGI Symbol;Acc:MGI:88524]|Heterozygous|Heterozygotes for a spontaneous mutation exhibit a dense nuclear cataract and mild microphthalmia by 2-months of age, followed by posterior capsular rupture into the posterior vitreous by 3-months. In homozygotes, the microphthalmia is more pronounced.|C|T|36|39.0|Non-synonymous|Unprocessed|APF-G1
1757606|IGL00772|10|12649185|R->C|||Benign|0.23|tolerated|MGI:104631|Utrn|utrophin [Source:MGI Symbol;Acc:MGI:104631]|Heterozygous|Homozygous null mutants have reduced density of acetylcholine receptors and reduced number of junctional folds at neuromuscular junctions. Mice homozygous for utrophin and dystrophin knockouts die prematurely with severe, progressive muscular dystrophy.|G|A|35|39.0|Non-synonymous|Unprocessed|APF-G1
1757607|IGL00772|11|69451257|Y->D||0.53|Possibly damaging|0.04|deleterious|MGI:107731|Dnahc2|dynein, axonemal, heavy chain 2 [Source:MGI Symbol;Acc:MGI:107731]|Heterozygous||A|C|34|35.0|Non-synonymous|Unprocessed|APF-G1
1757608|IGL00772|1|59169896|C->Stop|||N/A|||MGI:1921268|Als2|amyotrophic lateral sclerosis 2 (juvenile) homolog (human) [Source:MGI Symbol;Acc:MGI:1921268]|Heterozygous|Homozygous null mutations in this gene may result in increased body weight, altered endosome trafficking, modest motor behavioral abnormalities, altered anxiety responses, impaired  axonal transport, and mild neurolopathogical deficits including axonal  degeneration in the corticospinal tract.|A|T|29|39.0|Non-synonymous|Unprocessed|APF-G1
1757609|IGL00772|11|94645451|L->P||1.0|Probably damaging||deleterious|MGI:3576783|Eme1|essential meiotic endonuclease 1 homolog 1 (S. pombe) [Source:MGI Symbol;Acc:MGI:3576783]|Heterozygous||A|G|27|37.0|Non-synonymous|Unprocessed|APF-G1
1757610|IGL00772|5|108786165|D->G|||Benign|0.66|tolerated|MGI:1914616|Tmed11|transmembrane emp24 protein transport domain containing [Source:MGI Symbol;Acc:MGI:1914616]|Heterozygous||T|C|27|38.0|Non-synonymous|Unprocessed|APF-G1
1757611|IGL00772|11|12266985|M->T||0.98|Probably damaging|0.01|deleterious|MGI:105056|Cobl|cordon-bleu [Source:MGI Symbol;Acc:MGI:105056]|Heterozygous|Animals homozygous for this mutation do not display a phenotype.  However, the allele exacerbates the neural tube defects seen in the loop tail mouse.|A|G|25|37.0|Non-synonymous|Unprocessed|APF-G1
1757612|IGL00772|4|111938923|I->V||0.11|Benign|0.7|tolerated|MGI:3651523|Skint8|selection and upkeep of intraepithelial T cells 8 [Source:MGI Symbol;Acc:MGI:3651523]|Heterozygous||A|G|25|40.0|Non-synonymous|Unprocessed|APF-G1
1757613|IGL00772|7|86731784|S->P||0.98|Probably damaging||deleterious|MGI:1858193|Folh1|folate hydrolase [Source:MGI Symbol;Acc:MGI:1858193]|Heterozygous|Homozygous mutation of this gene results in protection from peripheral neuropathy and ischemic brain injury. Mutant mice also exhibit increased food intake, increased anxiety-related behavior, smaller sciatic nerve axons, and impaired angiogenesis.|A|G|23|38.0|Non-synonymous|Unprocessed|APF-G1
1757614|IGL00772|9|98992165|G->R||1.0|Probably damaging|0.15|tolerated|MGI:1344387|Faim|Fas apoptotic inhibitory molecule [Source:MGI Symbol;Acc:MGI:1344387]|Heterozygous|Mice homozygous for a null allele have thymocytes with an enhanced susceptibility to FAS-induced apoptosis, and B cells that more susceptible to activation induced cell death.|G|A|23|39.0|Non-synonymous|Unprocessed|APF-G1
1757615|IGL00772|8|13405349|T->A|||Benign|0.13|tolerated|MGI:1345146|Grk1|G protein-coupled receptor kinase 1 [Source:MGI Symbol;Acc:MGI:1345146]|Heterozygous|Analysis of homozygous null mice revealed abnormal photoresponses and light-induced apoptosis in rods. Mutant mice may serve as models of Oguchi disease and retinal degeneration.|A|G|21|37.0|Non-synonymous|Unprocessed|APF-G1
1757616|IGL00772|7|81471949|E->G||0.39|Benign|0.01|deleterious|MGI:1100869|Ap3b2|adaptor-related protein complex 3, beta 2 subunit [Source:MGI Symbol;Acc:MGI:1100869]|Heterozygous|Mice homozygous for a knock-out allele have normal coat and skin pigmentation but exhibit hyperactivity, tonic-clonic seizures, and significantly reduced synaptic zinc levels throughout the brain with the largest reduction observed in the CA1 stratum oriens.|T|C|16|39.0|Non-synonymous|Unprocessed|APF-G1
1757617|IGL00772|15|97789954|Y->C||1.0|Probably damaging|0.04|deleterious|MGI:1914989|Slc48a1|solute carrier family 48 (heme transporter), member 1 [Source:MGI Symbol;Acc:MGI:1914989]|Heterozygous|An uncharacterized gene trap insertion does not result in an obvious phenotype during the observation period early in life, although abnormalities may still develop at older age.|A|G|11|38.0|Non-synonymous|Unprocessed|APF-G1
1757618|IGL00772|5|24435196|V->L||0.99|Probably damaging||deleterious|MGI:109351|Slc4a2|solute carrier family 4 (anion exchanger), member 2 [Source:MGI Symbol;Acc:MGI:109351]|Heterozygous|Mice homozygous for a mutant allele display male infertility associated with disrupted spermiogenesis and germ cell apoptosis.  However, mice homozygous for a null allele display perinatal and postnatal lethality, loss of gastric acid secretion, failure of tooth eruption, aphagia, and deafness.|G|T|11|39.0|Non-synonymous|Unprocessed|APF-G1
1757619|IGL00772|6|29758894|K->Stop|||N/A|||MGI:108075|Smo|smoothened homolog (Drosophila) [Source:MGI Symbol;Acc:MGI:108075]|Heterozygous|Both an ENU-induced mutation and a null mutation are midgestation lethal. Observed defects include failure of neural tube closure and heart and gut defects. Conditional knockouts in chondrocytes and dental epithelium result in short long bones and dentalepithelium derivative defects, respectively.|A|T|11|37.0|Non-synonymous|Unprocessed|APF-G1
1757621|IGL00772|16|75550366|Disrupted splicing||||||MGI:2443868|Lipi|lipase, member I [Source:MGI Symbol;Acc:MGI:2443868]|Heterozygous||A|T|97|31.0|Splice|Unprocessed|APF-G1
1757622|IGL00772|13|41055820|Disrupted splicing||||||MGI:96913|Mak|male germ cell-associated kinase [Source:MGI Symbol;Acc:MGI:96913]|Heterozygous|Males homozygous for a targeted null mutation exhibit slight reductions in litter size and sperm motility in vitro.|A|T|91|39.0|Splice|Unprocessed|APF-G1
1757623|IGL00772|1|86090198|Disrupted splicing||||||MGI:1917497|Psmd1|proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 [Source:MGI Symbol;Acc:MGI:1917497]|Heterozygous||T|C|36|36.5|Splice|Unprocessed|APF-G1
1757624|IGL00772|8|122477238|Disrupted splicing||||0.16|tolerated|MGI:1914215|Ctu2|cytosolic thiouridylase subunit 2 homolog (S. pombe) [Source:MGI Symbol;Acc:MGI:1914215]|Heterozygous||T|C|23|34.0|Splice|Unprocessed|APF-G1
1757625|IGL00772|14|65670562|Disrupted splicing||||||MGI:1918395|Scara5|scavenger receptor class A, member 5 (putative) [Source:MGI Symbol;Acc:MGI:1918395]|Heterozygous||G|A|19|37.0|Splice|Unprocessed|APF-G1
1757626|IGL00772|9|113905992|Disrupted splicing||||||MGI:1923749|Clasp2|CLIP associating protein 2 [Source:MGI Symbol;Acc:MGI:1923749]|Heterozygous|Targeted deletion of this gene leads to impaired formation of stable microtubules in a wound healing assay, and results in a 2-fold reduction of directionally persistent migration in mutant embryonic fibroblasts.|A|G|10|40.5|Splice|Unprocessed|APF-G1
1758099|IGL00773|11|83035529|H->L||0.21|Benign|||MGI:3512288|Slfn10-ps|schlafen 10, pseudogene [Source:MGI Symbol;Acc:MGI:3512288]|Heterozygous||T|A|109|39.0|Non-synonymous|Unprocessed|APF-G1
1758100|IGL00773|15|47590719|M->T||0.98|Probably damaging||deleterious|MGI:2386403|Csmd3|CUB and Sushi multiple domains 3 [Source:MGI Symbol;Acc:MGI:2386403]|Heterozygous||A|G|98|40.0|Non-synonymous|Unprocessed|APF-G1
1758101|IGL00773|9|53522144|H->N||0.06|Benign|0.91|tolerated|MGI:107202|Atm|ataxia telangiectasia mutated homolog (human) [Source:MGI Symbol;Acc:MGI:107202]|Heterozygous|Homozygotes for null mutations may exhibit locomotor abnormalities, motor learning deficits, growth retardation, sterility due to meiotic arrest, and susceptibility to thymic lymphomas.|G|T|95|40.0|Non-synonymous|Unprocessed|APF-G1
1758102|IGL00773|3|36035337|L->P||1.0|Probably damaging|0.04|deleterious|MGI:2681852|Ccdc144b|coiled-coil domain containing 144B [Source:MGI Symbol;Acc:MGI:2681852]|Heterozygous||A|G|86|40.0|Non-synonymous|Unprocessed|APF-G1
1758103|IGL00773|19|22900159|M->K||0.96|Probably damaging|0.36|tolerated|MGI:2443101|Trpm3|transient receptor potential cation channel, subfamily M, member 3 [Source:MGI Symbol;Acc:MGI:2443101]|Heterozygous||T|A|85|40.0|Non-synonymous|Unprocessed|APF-G1
1758104|IGL00773|8|41274277|L->P||1.0|Probably damaging|0.12|tolerated|MGI:1277958|Pcm1|pericentriolar material 1 [Source:MGI Symbol;Acc:MGI:1277958]|Heterozygous||T|C|79|39.0|Non-synonymous|Unprocessed|APF-G1
1758105|IGL00773|9|88394539|D->E||0.99|Probably damaging|0.22|tolerated|MGI:2155664|Snx14|sorting nexin 14 [Source:MGI Symbol;Acc:MGI:2155664]|Heterozygous||A|T|49|39.0|Non-synonymous|Unprocessed|APF-G1
1758106|IGL00773|2|3519355|D->G||0.11|Benign|0.12|tolerated|MGI:3606576|Cdnf|cerebral dopamine neurotrophic factor [Source:MGI Symbol;Acc:MGI:3606576]|Heterozygous||A|G|40|36.0|Non-synonymous|Unprocessed|APF-G1
1758107|IGL00773|3|59331539|V->A||0.04|Benign|0.35|tolerated|MGI:1923481|Igsf10|immunoglobulin superfamily, member 10 [Source:MGI Symbol;Acc:MGI:1923481]|Heterozygous||A|G|39|38.0|Non-synonymous|Unprocessed|APF-G1
1758108|IGL00773|6|24118017|M->I||0.48|Possibly damaging|0.04|deleterious|MGI:1859937|Slc13a1|solute carrier family 13 (sodium/sulfate symporters), member 1 [Source:MGI Symbol;Acc:MGI:1859937]|Heterozygous|Homozygous mutant mice exhibit hyposulfatemia, growth retardation, reduced female fertility, and spontaneous clonic seizures.|C|T|38|39.0|Non-synonymous|Unprocessed|APF-G1
1758109|IGL00773|17|84606868|T->M||0.12|Benign||deleterious|MGI:2146813|Plekhh2|pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 [Source:MGI Symbol;Acc:MGI:2146813]|Heterozygous||C|T|37|37.0|Non-synonymous|Unprocessed|APF-G1
1758110|IGL00773|X|166502861|L->F||0.01|Benign|0.74|tolerated|MGI:2685236|Tceanc|transcription elongation factor A (SII) N-terminal and central domain containing [Source:MGI Symbol;Acc:MGI:2685236]|Heterozygous||T|A|37|40.0|Non-synonymous|Unprocessed|APF-G1
1758111|IGL00773|16|63566684|Q->L||0.96|Probably damaging|0.13|tolerated|MGI:99612|Epha3|Eph receptor A3 [Source:MGI Symbol;Acc:MGI:99612]|Heterozygous|Mice homozygous for disruptions in this gene usually die within 48 hours of birth of cardiac failure.  Survivors develop normally with no indications of cardiac abnormalities.|T|A|34|37.5|Non-synonymous|Unprocessed|APF-G1
1758112|IGL00773|1|176755399|D->G||1.0|Probably damaging||deleterious|MGI:1918348|Cep170|centrosomal protein 170 [Source:MGI Symbol;Acc:MGI:1918348]|Heterozygous||T|C|30|36.5|Non-synonymous|Unprocessed|APF-G1
1758113|IGL00773|3|95765109|F->Y||1.0|Probably damaging|0.03|deleterious|MGI:1922387|Rprd2|regulation of nuclear pre-mRNA domain containing 2 [Source:MGI Symbol;Acc:MGI:1922387]|Heterozygous||A|T|26|36.5|Non-synonymous|Unprocessed|APF-G1
1758114|IGL00773|14|20447534|S->P||0.74|Possibly damaging|0.03|deleterious|MGI:1923920|Ttc18|tetratricopeptide repeat domain 18 [Source:MGI Symbol;Acc:MGI:1923920]|Heterozygous||A|G|23|32.0|Non-synonymous|Unprocessed|APF-G1
1758115|IGL00773|16|97952320|D->E|||Benign|0.29|tolerated|MGI:1927240|Zfp295|zinc finger protein 295 [Source:MGI Symbol;Acc:MGI:1927240]|Heterozygous||A|T|22|37.0|Non-synonymous|Unprocessed|APF-G1
1758116|IGL00773|5|103784077|S->F||1.0|Probably damaging|0.41|tolerated|MGI:1100819|Aff1|AF4/FMR2 family, member 1 [Source:MGI Symbol;Acc:MGI:1100819]|Heterozygous|Homozygotes for a targeted null mutation exhibit impaired B and T cell development. Heterozygotes for an ENU-induced mutation exhibit small size, ataxia, adult-onset Purkinje cell loss, cataracts, reduced survival, and low fertility.|C|T|20|38.5|Non-synonymous|Unprocessed|APF-G1
1758117|IGL00773|6|23002629|K->E||0.12|Benign|0.07|tolerated|MGI:97816|Ptprz1|protein tyrosine phosphatase, receptor type Z, polypeptide 1 [Source:MGI Symbol;Acc:MGI:97816]|Heterozygous|Mice homozygous for targeted null mutations demonstrate an impaired ability to recover from inflamatory lesions of the CNS or gastric mucosa.  Mice homozygous for a knock-out allele exhibit increased tactile and thermal nociception thresholds.|A|G|20|39.0|Non-synonymous|Unprocessed|APF-G1
1758118|IGL00773|18|34747241|S->T||1.0|Probably damaging|0.07|tolerated|MGI:88350|Cdc25c|cell division cycle 25 homolog C (S. pombe) [Source:MGI Symbol;Acc:MGI:88350]|Heterozygous|Mice homozygous for a targeted null mutation exhibit no discernable phenotype; mice are viable and fertile with normal T and B lymphocyte development and proliferative responses.|A|T|19|38.0|Non-synonymous|Unprocessed|APF-G1
1758119|IGL00773|12|98688313|M->I||||1.0|tolerated|MGI:1344406|Ptpn21|protein tyrosine phosphatase, non-receptor type 21 [Source:MGI Symbol;Acc:MGI:1344406]|Heterozygous||C|T|17|35.0|Non-synonymous|Unprocessed|APF-G1
1758120|IGL00773|9|106858333|S->T||0.2|Benign|0.12|tolerated|MGI:2445220|Vprbp|Vpr (HIV-1) binding protein [Source:MGI Symbol;Acc:MGI:2445220]|Heterozygous|Embryos homozygous for a knock-out allele die prior to E7.5.|T|A|17|33.0|Non-synonymous|Unprocessed|APF-G1
1758121|IGL00773|13|73544741|I->N||1.0|Probably damaging||deleterious|MGI:94862|Slc6a3|solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 [Source:MGI Symbol;Acc:MGI:94862]|Heterozygous|Homozygotes for targeted null mutations exhibit dwarfism, hyperactivity (especially in a novel environment), 5-fold higher extracellular dopamine levels, impaired spatial cognitive function, anterior pituitary hypoplasia, and failure to lactate.|T|A|16|39.0|Non-synonymous|Unprocessed|APF-G1
1758122|IGL00773|4|43518251|K->E||1.0|Probably damaging||deleterious|MGI:98810|Tpm2|tropomyosin 2, beta [Source:MGI Symbol;Acc:MGI:98810]|Heterozygous||T|C|15|39.0|Non-synonymous|Unprocessed|APF-G1
1758123|IGL00773|10|77949214|R->Stop|||N/A|||MGI:1351901|Trpm2|transient receptor potential cation channel, subfamily M, member 2 [Source:MGI Symbol;Acc:MGI:1351901]|Heterozygous|Mice homozygous for a knock-out allele display impaired reactive oxygen species (ROS)-induced chemokine production in monocytes, and reduced neutrophil infiltration and ulceration in a dextran sulfate sodium-induced colitis inflammation model.|T|A|13|39.0|Non-synonymous|Unprocessed|APF-G1
1758124|IGL00773|17|43602871|I->S||1.0|Probably damaging||deleterious|MGI:1351327|Pla2g7|phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) [Source:MGI Symbol;Acc:MGI:1351327]|Heterozygous||T|G|13|39.0|Non-synonymous|Unprocessed|APF-G1
1758125|IGL00773|5|90604140|V->M||1.0|Probably damaging||deleterious|MGI:1920496|Rassf6|Ras association (RalGDS/AF-6) domain family member 6 [Source:MGI Symbol;Acc:MGI:1920496]|Heterozygous||C|T|13|39.0|Non-synonymous|Unprocessed|APF-G1
1758126|IGL00773|4|107084296|A->V|||Benign|0.68|tolerated|MGI:1919657|Cyb5rl|cytochrome b5 reductase-like [Source:MGI Symbol;Acc:MGI:1919657]|Heterozygous||C|T|12|38.0|Non-synonymous|Unprocessed|APF-G1
1758127|IGL00773|11|67194421|I->T||||0.34|tolerated|MGI:1339710|Myh2|myosin, heavy polypeptide 2, skeletal muscle, adult [Source:MGI Symbol;Acc:MGI:1339710]|Heterozygous||T|C|11|37.0|Non-synonymous|Unprocessed|APF-G1
1758128|IGL00773|19|8621868|I->F||0.3|Benign|0.35|tolerated|MGI:892001|Slc22a6|solute carrier family 22 (organic anion transporter), member 6 [Source:MGI Symbol;Acc:MGI:892001]|Heterozygous|Homozygous mutation of this gene may result in increased thymus weight or impaired renal organic anion excretion for a subset of organic anions.|A|T|11|37.0|Non-synonymous|Unprocessed|APF-G1
1758132|IGL00773|2|114048113|Disrupted splicing||||||MGI:87905|Actc1|actin, alpha, cardiac muscle 1 [Source:MGI Symbol;Acc:MGI:87905]|Heterozygous|Homozygous null mutation of this gene results in embryonic and postnatal lethality. Animals that survive to birth die within the first 2 weeks and display reduced body size and heart muscle defects.|T|C|17|36.0|Splice|Unprocessed|APF-G1
1758593|IGL00774|4|11593765|R->K|||Benign|1.0|tolerated|MGI:3605986|Rad54b|RAD54 homolog B (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:3605986]|Heterozygous||G|A|244|39.0|Non-synonymous|Unprocessed|APF-G1
1758594|IGL00774|8|110817638|I->N||0.89|Possibly damaging|0.2|tolerated|MGI:1289341|Sf3b3|splicing factor 3b, subunit 3 [Source:MGI Symbol;Acc:MGI:1289341]|Heterozygous||A|T|226|38.0|Non-synonymous|Unprocessed|APF-G1
1758595|IGL00774|2|65735853|D->G||1.0|Probably damaging||deleterious|MGI:98248|Scn2a1|sodium channel, voltage-gated, type II, alpha 1 [Source:MGI Symbol;Acc:MGI:98248]|Heterozygous|Homozygotes for a targeted mutation exhibit excess neuronal apoptosis (especially in the brainstem), reduced neuronal sodium channel currents in vitro, and severe hypoxia resulting in neonatal lethality.|A|G|98|39.0|Non-synonymous|Unprocessed|APF-G1
1758596|IGL00774|15|38006541|T->A||0.27|Benign|0.28|tolerated|MGI:1918040|Ubr5|ubiquitin protein ligase E3 component n-recognin 5 [Source:MGI Symbol;Acc:MGI:1918040]|Heterozygous|Homozygous null mice display embryonic lethality during organogenesis, impaired growth of the allantois, failure or impairment of chorioallantoic fusion, impaired angiogenesis in the yolk sac and allantois, decreased cell proliferation, and increased apoptosis.|T|C|82|36.0|Non-synonymous|Unprocessed|APF-G1
1758597|IGL00774|12|30588721|R->G|||Unknown|0.09|tolerated|MGI:2387176|Tmem18|transmembrane protein 18 [Source:MGI Symbol;Acc:MGI:2387176]|Heterozygous||A|G|80|37.0|Non-synonymous|Unprocessed|APF-G1
1758598|IGL00774|3|27098443|R->W||1.0|Probably damaging||deleterious|MGI:95281|Ect2|ect2 oncogene [Source:MGI Symbol;Acc:MGI:95281]|Heterozygous|Homozygous disruption of this locus is embryonic lethal.|G|A|70|38.5|Non-synonymous|Unprocessed|APF-G1
1758599|IGL00774|4|115532538|I->F||1.0|Probably damaging||deleterious|MGI:88611|Cyp4a10|cytochrome P450, family 4, subfamily a, polypeptide 10 [Source:MGI Symbol;Acc:MGI:88611]|Heterozygous|Mice homozygous for a null mutation display salt-sensitive hypertension, decrease sodium excretion, and decreased urine output.|A|T|66|40.0|Non-synonymous|Unprocessed|APF-G1
1758600|IGL00774|1|105597756|V->A||||0.14|tolerated|MGI:1351629|Pign|phosphatidylinositol glycan anchor biosynthesis, class N [Source:MGI Symbol;Acc:MGI:1351629]|Heterozygous||A|G|61|39.0|Non-synonymous|Unprocessed|APF-G1
1758601|IGL00774|12|4855303|E->G||1.0|Probably damaging|0.05|deleterious|MGI:3040699|Bc068281|cDNA sequence BC068281 [Source:MGI Symbol;Acc:MGI:3040699]|Heterozygous||A|G|55|37.0|Non-synonymous|Unprocessed|APF-G1
1758602|IGL00774|2|28665011|H->L||0.87|Possibly damaging|0.03|deleterious|MGI:1929183|Tsc1|tuberous sclerosis 1 [Source:MGI Symbol;Acc:MGI:1929183]|Heterozygous|Homozygous null mutants show liver hypoplasia, open neural tube and die by embryonic day 10.5-11.5. Heterozygotes develop kidney cystadenomas and liver hemangiomas. Conditional astrocyte-specific nulls show increased astrocyte numbers and seizures.|A|T|54|38.0|Non-synonymous|Unprocessed|APF-G1
1758603|IGL00774|4|152052015|S->P||0.92|Possibly damaging|0.22|tolerated|MGI:1921285|Nol9|nucleolar protein 9 [Source:MGI Symbol;Acc:MGI:1921285]|Heterozygous||T|C|54|39.0|Non-synonymous|Unprocessed|APF-G1
1758604|IGL00774|4|49536843|S->P||0.1|Benign|0.12|tolerated|MGI:87995|Aldob|aldolase B, fructose-bisphosphate [Source:MGI Symbol;Acc:MGI:87995]|Heterozygous||A|G|53|37.0|Non-synonymous|Unprocessed|APF-G1
1758605|IGL00774|4|86388539|A->T||0.34|Benign|0.47|tolerated|MGI:1924989|Adamtsl1|ADAMTS-like 1 [Source:MGI Symbol;Acc:MGI:1924989]|Heterozygous||G|A|51|35.0|Non-synonymous|Unprocessed|APF-G1
1758606|IGL00774|11|60205139|R->Q||0.46|Possibly damaging|0.01|deleterious|MGI:107606|Srebf1|sterol regulatory element binding transcription factor 1 [Source:MGI Symbol;Acc:MGI:107606]|Heterozygous|Mice homozygous for a knock-out allele of transcript A die between E11.5 and E14.5. Mice homozygous for a knock-out allele of transcript C exhibit decreased circulating triglyceride levels. Mice homozygous for a gene trap allele exhibit decreased hepatic triglyceride storage.|C|T|48|38.0|Non-synonymous|Unprocessed|APF-G1
1758607|IGL00774|13|29918704|D->E||0.9|Possibly damaging|0.03|deleterious|MGI:1096340|E2f3|E2F transcription factor 3 [Source:MGI Symbol;Acc:MGI:1096340]|Heterozygous|Mice homozygous for a null allele exhibit increased lethality prior to adulthood but otherwise appear normal.  Mouse embryonic fibroblast cells from mice homozygous for a null allele are defective in cell cycle progression and exhibit reduced proliferation.|A|T|45|39.0|Non-synonymous|Unprocessed|APF-G1
1758608|IGL00774|8|104292930|S->P||0.96|Probably damaging|0.38|tolerated|MGI:2447160|Cmtm2a|CKLF-like MARVEL transmembrane domain containing 2A [Source:MGI Symbol;Acc:MGI:2447160]|Heterozygous||A|G|43|36.0|Non-synonymous|Unprocessed|APF-G1
1758609|IGL00774|1|53320246|I->V||0.16|Benign|0.09|tolerated|MGI:1919335|Osgepl1|O-sialoglycoprotein endopeptidase-like 1 [Source:MGI Symbol;Acc:MGI:1919335]|Heterozygous||A|G|41|37.0|Non-synonymous|Unprocessed|APF-G1
1758610|IGL00774|15|54254072|R->S||0.55|Possibly damaging|0.02|deleterious|MGI:109587|Tnfrsf11b|tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) [Source:MGI Symbol;Acc:MGI:109587]|Heterozygous|Homozygote null mice have abnormal bone remodeling that results in severe osteoperosis with increased risk of fractures and growth retardation.  Progressive hearing loss also results due to abnormal remodeling of the otic capsule.|T|G|39|37.0|Non-synonymous|Unprocessed|APF-G1
1758611|IGL00774|10|109816263|D->G||0.02|Benign|0.34|tolerated|MGI:2183703|Nav3|neuron navigator 3 [Source:MGI Symbol;Acc:MGI:2183703]|Heterozygous||T|C|32|37.0|Non-synonymous|Unprocessed|APF-G1
1758612|IGL00774|9|70631033|D->G||0.04|Benign|0.4|tolerated|MGI:2443086|Fam63b|family with sequence similarity 63, member B [Source:MGI Symbol;Acc:MGI:2443086]|Heterozygous||T|C|28|38.5|Non-synonymous|Unprocessed|APF-G1
1758613|IGL00774|18|32228239|P->L||0.04|Benign|0.21|tolerated|MGI:1346873|Map3k2|mitogen-activated protein kinase kinase kinase 2 [Source:MGI Symbol;Acc:MGI:1346873]|Heterozygous|Mice homozygous for disruptions in this gene are grossly normal and fertile.|C|T|18|38.5|Non-synonymous|Unprocessed|APF-G1
1758615|IGL00774|4|136994524|H->P||1.0|Probably damaging||deleterious|MGI:2682254|Zbtb40|zinc finger and BTB domain containing 40 [Source:MGI Symbol;Acc:MGI:2682254]|Heterozygous||T|G|14|36.5|Non-synonymous|Unprocessed|APF-G1
1758618|IGL00774|15|91801833|Disrupted splicing||||||MGI:1913975|Lrrk2|leucine-rich repeat kinase 2 [Source:MGI Symbol;Acc:MGI:1913975]|Heterozygous|Mice homozygous for a knock-in allele exhibit impaired response to dopamine, amphetamine, and quinpirole.  Mice homozygous for one knock-out allele exhibit increased neurite growth. Mice homozygous for different knock-out alleles exhibit alopecia due to excessive grooming or kdiney atrophy.|T|G|159|39.0|Splice|Unprocessed|APF-G1
1758619|IGL00774|13|61198339|Disrupted splicing||||||MGI:1889619|Cts6|cathepsin 6 [Source:MGI Symbol;Acc:MGI:1889619]|Heterozygous||T|C|126|38.0|Splice|Unprocessed|APF-G1
1758620|IGL00774|9|21987722|Disrupted splicing||||||MGI:1918996|Rgl3|ral guanine nucleotide dissociation stimulator-like 3 [Source:MGI Symbol;Acc:MGI:1918996]|Heterozygous||A|T|98|35.0|Splice|Unprocessed|APF-G1
1758621|IGL00774|5|72108446|Disrupted splicing||||||MGI:95619|Gabrb1|gamma-aminobutyric acid (GABA) A receptor, subunit beta 1 [Source:MGI Symbol;Acc:MGI:95619]|Heterozygous||G|T|96|39.5|Splice|Unprocessed|APF-G1
1758622|IGL00774|12|108514515|Disrupted splicing||||||MGI:1915769|Eml1|echinoderm microtubule associated protein like 1 [Source:MGI Symbol;Acc:MGI:1915769]|Heterozygous||A|G|81|34.0|Splice|Unprocessed|APF-G1
1758623|IGL00774|X|17558013|Disrupted splicing||||||MGI:1919268|Fundc1|FUN14 domain containing 1 [Source:MGI Symbol;Acc:MGI:1919268]|Heterozygous||T|A|64|40.0|Splice|Unprocessed|APF-G1
1758624|IGL00774|3|101283029|Disrupted splicing||||||MGI:88320|Cd2|CD2 antigen [Source:MGI Symbol;Acc:MGI:88320]|Heterozygous|Homozygous mutation of this gene does not appear to result in a phenotype.|A|T|53|39.0|Splice|Unprocessed|APF-G1
1759138|IGL00775|5|98784510|Y->H||0.92|Possibly damaging|0.21|tolerated|MGI:1916571|1700007g11rik|RIKEN cDNA 1700007G11 gene [Source:MGI Symbol;Acc:MGI:1916571]|Heterozygous||T|C|122|39.0|Non-synonymous|Unprocessed|APF-G1
1759139|IGL00775|13|24840538|T->A||1.0|Probably damaging|0.12|tolerated|MGI:1860486|Tdp2|tyrosyl-DNA phosphodiesterase 2 [Source:MGI Symbol;Acc:MGI:1860486]|Heterozygous|Homozygous mutant mice carrying a gene trap insertion into intron 5 but subsequently shown to harbor a partial duplication of the wild-type allele at the ES cell level are born with a normal Mendelian distribution.|A|G|47|38.0|Non-synonymous|Unprocessed|APF-G1
1759140|IGL00775|11|72728772|G->D||0.06|Benign|0.19|tolerated|MGI:1337008|Ankfy1|ankyrin repeat and FYVE domain containing 1 [Source:MGI Symbol;Acc:MGI:1337008]|Heterozygous||G|A|46|38.0|Non-synonymous|Unprocessed|APF-G1
1759141|IGL00775|5|105017845|N->S||1.0|Probably damaging||deleterious|MGI:1923324|Gbp8|guanylate-binding protein 8 [Source:MGI Symbol;Acc:MGI:1923324]|Heterozygous||T|C|36|40.0|Non-synonymous|Unprocessed|APF-G1
1759142|IGL00775|18|37519742|V->A||0.75|Possibly damaging|0.62|tolerated|MGI:2136760|Pcdhb22|protocadherin beta 22 [Source:MGI Symbol;Acc:MGI:2136760]|Heterozygous||T|C|30|38.5|Non-synonymous|Unprocessed|APF-G1
1759143|IGL00775|4|114194692|D->V||1.0|Probably damaging||deleterious|MGI:2685415|Skint11|selection and upkeep of intraepithelial T cells 11 [Source:MGI Symbol;Acc:MGI:2685415]|Heterozygous||A|T|29|37.0|Non-synonymous|Unprocessed|APF-G1
1759144|IGL00775|4|3904055|S->P|||Benign|0.32|tolerated|MGI:1891916|Plag1|pleiomorphic adenoma gene 1 [Source:MGI Symbol;Acc:MGI:1891916]|Heterozygous|Homozygous null mice display reduced male fertility, small seminal vesicles and ventral prostate, reduced litter size (females only), reduced embryonic and postnatal growth, and delayed eyelid opening.|A|G|18|38.0|Non-synonymous|Unprocessed|APF-G1
1759145|IGL00775|8|13879509|S->P||1.0|Probably damaging|0.05|tolerated|MGI:1196398|Zfp828|zinc finger protein 828 [Source:MGI Symbol;Acc:MGI:1196398]|Heterozygous||T|C|18|36.0|Non-synonymous|Unprocessed|APF-G1
1759146|IGL00775|7|119658301|N->S||0.02|Benign|0.05|deleterious|MGI:2152200|Acsm1|acyl-CoA synthetase medium-chain family member 1 [Source:MGI Symbol;Acc:MGI:2152200]|Heterozygous||A|G|16|38.5|Non-synonymous|Unprocessed|APF-G1
1759147|IGL00775|5|138133048|S->Stop|||N/A|||MGI:99182|Zscan21|zinc finger and SCAN domain containing 21 [Source:MGI Symbol;Acc:MGI:99182]|Heterozygous|Homozygotes for a targeted null mutation appear to be phenotypically normal.|C|A|14|38.0|Non-synonymous|Unprocessed|APF-G1
1759148|IGL00775|8|24921354|Y->C||1.0|Probably damaging|0.02|deleterious|MGI:2653822|Adam32|a disintegrin and metallopeptidase domain 32 [Source:MGI Symbol;Acc:MGI:2653822]|Heterozygous||T|C|14|37.0|Non-synonymous|Unprocessed|APF-G1
1759149|IGL00775|17|30767906|Y->Stop|||N/A|||MGI:107714|Dnahc8|dynein, axonemal, heavy chain 8 [Source:MGI Symbol;Acc:MGI:107714]|Heterozygous||T|G|11|38.0|Non-synonymous|Unprocessed|APF-G1
1759152|IGL00775|10|12745230|Disrupted splicing||||||MGI:104631|Utrn|utrophin [Source:MGI Symbol;Acc:MGI:104631]|Heterozygous|Homozygous null mutants have reduced density of acetylcholine receptors and reduced number of junctional folds at neuromuscular junctions. Mice homozygous for utrophin and dystrophin knockouts die prematurely with severe, progressive muscular dystrophy.|A|G|41|38.0|Splice|Unprocessed|APF-G1
1759153|IGL00775|11|70724134|Disrupted splicing||||||MGI:1098260|Kif1c|kinesin family member 1C [Source:MGI Symbol;Acc:MGI:1098260]|Heterozygous|Mice homozygous for a reporter allele are viable, fertile and overtly normal and display normal motor-dependent retrograde Golgi apparatus-to-endoplasmic reticulum transport.|A|G|13|38.0|Splice|Unprocessed|APF-G1
1759611|IGL00776|9|66421038|H->Q|||Benign|0.37|tolerated|MGI:2384589|Herc1|hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1 [Source:MGI Symbol;Acc:MGI:2384589]|Heterozygous|Homozygotes for this spontaneous mutation exhibit an abnormal cerebellar Purkinje cell layer and Purkinje cell degeneration.|T|A|430|39.0|Non-synonymous|Unprocessed|APF-G1
1759612|IGL00776|12|56770205|T->I||0.19|Benign|0.32|tolerated|MGI:2445059|Slc25a21|solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21 [Source:MGI Symbol;Acc:MGI:2445059]|Heterozygous||G|A|256|40.0|Non-synonymous|Unprocessed|APF-G1
1759613|IGL00776|5|3891809|W->G||1.0|Probably damaging||deleterious|MGI:1918240|Mterf|mitochondrial transcription termination factor [Source:MGI Symbol;Acc:MGI:1918240]|Heterozygous||A|C|88|38.0|Non-synonymous|Unprocessed|APF-G1
1759614|IGL00776|19|40597421|F->S||0.92|Possibly damaging||deleterious|MGI:1914840|Tctn3|tectonic family member 3 [Source:MGI Symbol;Acc:MGI:1914840]|Heterozygous||A|G|77|37.0|Non-synonymous|Unprocessed|APF-G1
1759615|IGL00776|12|118919854|S->G||1.0|Probably damaging||deleterious|MGI:1924956|Abcb5|ATP-binding cassette, sub-family B (MDR/TAP), member 5 [Source:MGI Symbol;Acc:MGI:1924956]|Heterozygous||T|C|72|38.0|Non-synonymous|Unprocessed|APF-G1
1759616|IGL00776|2|125080889|S->P||0.99|Probably damaging|0.01|deleterious|MGI:2677271|Slc24a5|solute carrier family 24, member 5 [Source:MGI Symbol;Acc:MGI:2677271]|Heterozygous||T|C|66|38.0|Non-synonymous|Unprocessed|APF-G1
1759617|IGL00776|2|62850376|I->T|||Benign|0.58|tolerated|MGI:2159566|Kcnh7|potassium voltage-gated channel, subfamily H (eag-related), member 7 [Source:MGI Symbol;Acc:MGI:2159566]|Heterozygous||A|G|46|37.5|Non-synonymous|Unprocessed|APF-G1
1759618|IGL00776|2|19540371|D->E||0.22|Benign|0.38|tolerated|MGI:1918087|4921504e06rik|RIKEN cDNA 4921504E06 gene [Source:MGI Symbol;Acc:MGI:1918087]|Heterozygous||A|T|43|39.0|Non-synonymous|Unprocessed|APF-G1
1759619|IGL00776|7|16830452|R->C||1.0|Probably damaging|0.01|deleterious|MGI:2142346|Strn4|striatin, calmodulin binding protein 4 [Source:MGI Symbol;Acc:MGI:2142346]|Heterozygous||C|T|35|37.0|Non-synonymous|Unprocessed|APF-G1
1759620|IGL00776|11|69669096|L->F||0.97|Probably damaging|0.01|deleterious|MGI:95303|Eif4a1|eukaryotic translation initiation factor 4A1 [Source:MGI Symbol;Acc:MGI:95303]|Heterozygous||G|A|29|38.0|Non-synonymous|Unprocessed|APF-G1
1759621|IGL00776|5|67749143|I->N||0.1|Benign|0.19|tolerated|MGI:1330848|Atp8a1|ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 [Source:MGI Symbol;Acc:MGI:1330848]|Heterozygous|Homozygous mutant mice are viable, fertile and phenotypically normal.|A|T|26|36.5|Non-synonymous|Unprocessed|APF-G1
1759622|IGL00776|14|30889604|V->I|||Benign|1.0|tolerated|MGI:109536|Itih4|inter alpha-trypsin inhibitor, heavy chain 4 [Source:MGI Symbol;Acc:MGI:109536]|Heterozygous|Mice homozygous for a knock-out allele are viable, fertile and overtly normal. Surprisingly, IL-6/STAT3 signaling is significantly suppressed in mutant liver tissues but hepatocytes remain well differentiated.|G|A|25|36.0|Non-synonymous|Unprocessed|APF-G1
1759623|IGL00776|5|144881774|S->P||0.43|Benign|0.02|deleterious|MGI:1923038|Smurf1|SMAD specific E3 ubiquitin protein ligase 1 [Source:MGI Symbol;Acc:MGI:1923038]|Heterozygous|Mice homozygous for one knock-out allele display increased osteoblast function, bone density, and thickness of the cortical bone in long bones.  Mice homozygous for a different knock-out allele are viable and only display gastrulation defects in combination with a Smurf2 knock-out allele.|A|G|23|38.0|Non-synonymous|Unprocessed|APF-G1
1759624|IGL00776|15|101473860|H->Y|||Benign|0.11|tolerated|MGI:109362|Krt86|keratin 86 [Source:MGI Symbol;Acc:MGI:109362]|Heterozygous||C|T|15|37.0|Non-synonymous|Unprocessed|APF-G1
1759625|IGL00776|10|81643145|Q->P|||Unknown|0.06|tolerated|MGI:1890394|Ankrd24|ankyrin repeat domain 24 [Source:MGI Symbol;Acc:MGI:1890394]|Heterozygous||A|C|12|37.0|Non-synonymous|Unprocessed|APF-G1
1759626|IGL00776|19|40344351|Disrupted splicing||||||MGI:700014|Sorbs1|sorbin and SH3 domain containing 1 [Source:MGI Symbol;Acc:MGI:700014]|Heterozygous|Mice homozygous for a null allele exhibit decreased triglyceride levels, altered glucose homeostasis, decreased white blood cells and resistance to developing glucose intolerance induced by a high fat diet.|C|T|278|37.0|Splice|Unprocessed|APF-G1
1760136|IGL00777|X|123142873|L->P||0.98|Probably damaging||deleterious|MGI:1920311|3110007f17rik|RIKEN cDNA 3110007F17 gene [Source:MGI Symbol;Acc:MGI:1920311]|Heterozygous||T|C|133|38.0|Non-synonymous|Unprocessed|APF-G1
1760137|IGL00777|5|45695765|S->G||0.84|Possibly damaging|0.02|deleterious|MGI:1930197|Ncapg|non-SMC condensin I complex, subunit G [Source:MGI Symbol;Acc:MGI:1930197]|Heterozygous||A|G|127|39.0|Non-synonymous|Unprocessed|APF-G1
1760138|IGL00777|17|81648580|I->T|||Benign|0.38|tolerated|MGI:107956|Slc8a1|solute carrier family 8 (sodium/calcium exchanger), member 1 [Source:MGI Symbol;Acc:MGI:107956]|Heterozygous|Homozygotes for targeted null mutations have underdeveloped, nonbeating hearts with massive apoptosis of myocytes, a dilated pericardium and die around embryonic day 9.5. Heterozygotes exhibit altered responses to experimental cardiac pressure overload.|A|G|90|39.0|Non-synonymous|Unprocessed|APF-G1
1760139|IGL00777|4|43448365|Y->C||0.83|Possibly damaging|0.14|tolerated|MGI:88345|Cd72|CD72 antigen [Source:MGI Symbol;Acc:MGI:88345]|Heterozygous|Homozygous mutation of this gene results in impaired B cell development and delayed maturation, resulting in reduced numbers of mature B cells and an expansion of pre-B cells. Mice have fewer peripheral mature B-2 cells and more B-1 cells. B cells are hyperproliferative in response to stimuli.|T|C|87|36.0|Non-synonymous|Unprocessed|APF-G1
1760140|IGL00777|13|23622022|K->M|||Unknown|0.01|deleterious|MGI:1931527|Hist1h1e|histone cluster 1, H1e [Source:MGI Symbol;Acc:MGI:1931527]|Heterozygous|Homozygotes for targeted null mutations are normal, but Hist1h1e/Hist1h1c double knockout males are significantly smaller than normal. The Hist1h1e/Hist1h1d/Hist1h1e triple knockout is lethal by embryonic day 12.5, and heterozygotes are underrepresented.|T|A|77|35.0|Non-synonymous|Unprocessed|APF-G1
1760141|IGL00777|2|121429556|L->Q||1.0|Probably damaging||deleterious|MGI:95834|Pdia3|protein disulfide isomerase associated 3 [Source:MGI Symbol;Acc:MGI:95834]|Heterozygous|Mice homozygous for a knock-out allele die by E13.5 with minor changes in ER calcium capacity and unfolded protein response in mouse embryonic fibroblasts. Mice homozygous for a gene trap allele die prior to birth while heterozygous mice exhibit abnormal bone volume bone morphology.|T|A|59|39.0|Non-synonymous|Unprocessed|APF-G1
1760142|IGL00777|10|62991054|C->Y||0.12|Benign|0.01|deleterious|MGI:1917682|Rufy2|RUN and FYVE domain-containing 2 [Source:MGI Symbol;Acc:MGI:1917682]|Heterozygous||G|A|58|36.0|Non-synonymous|Unprocessed|APF-G1
1760143|IGL00777|1|26682092|D->Y||1.0|Probably damaging|0.02|deleterious|MGI:3588222|4931408c20rik|RIKEN cDNA 4931408C20 gene [Source:MGI Symbol;Acc:MGI:3588222]|Heterozygous||C|A|51|38.0|Non-synonymous|Unprocessed|APF-G1
1760144|IGL00777|16|32836563|C->R||0.99|Probably damaging||deleterious|MGI:1915160|1700021k19rik|RIKEN cDNA 1700021K19 gene [Source:MGI Symbol;Acc:MGI:1915160]|Heterozygous||A|G|51|36.0|Non-synonymous|Unprocessed|APF-G1
1760145|IGL00777|5|86524065|Y->H||1.0|Probably damaging||deleterious|MGI:2442348|Tmprss11f|transmembrane protease, serine 11f [Source:MGI Symbol;Acc:MGI:2442348]|Heterozygous||A|G|50|37.0|Non-synonymous|Unprocessed|APF-G1
1760146|IGL00777|X|157177532|L->P||1.0|Probably damaging|0.34|tolerated|MGI:107489|Phex|phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets) [Source:MGI Symbol;Acc:MGI:107489]|Heterozygous|Males hemizygous for a null mutation exhibit reduced body size, shortened hindlimbs and tail, osteomalacia, and markedly reduced plasma phosphate levels due to impaired kidney reabsorption. Female heterozygotes exhibit milder symptoms.|A|G|41|38.0|Non-synonymous|Unprocessed|APF-G1
1760147|IGL00777|1|128287556|D->G|||Benign|0.38|tolerated|MGI:104576|Lct|lactase [Source:MGI Symbol;Acc:MGI:104576]|Heterozygous||T|C|37|34.0|Non-synonymous|Unprocessed|APF-G1
1760148|IGL00777|4|155651007|Y->S||0.06|Benign|0.45|tolerated|MGI:1347361|Mmp23|matrix metallopeptidase 23 [Source:MGI Symbol;Acc:MGI:1347361]|Heterozygous||T|G|37|37.0|Non-synonymous|Unprocessed|APF-G1
1760149|IGL00777|3|83899290|P->T||0.99|Probably damaging|0.03|deleterious|MGI:2443399|D930015e06rik|RIKEN cDNA D930015E06 gene [Source:MGI Symbol;Acc:MGI:2443399]|Heterozygous||G|T|35|33.0|Non-synonymous|Unprocessed|APF-G1
1760150|IGL00777|16|37613249|T->A||1.0|Probably damaging|0.02|deleterious|MGI:96078|Hgd|homogentisate 1, 2-dioxygenase [Source:MGI Symbol;Acc:MGI:96078]|Heterozygous|Mutations in this gene result in high levels of urinary homogentisic acid.|A|G|34|38.0|Non-synonymous|Unprocessed|APF-G1
1760151|IGL00777|2|5929657|L->H||1.0|Probably damaging||deleterious|MGI:2445096|Dhtkd1|dehydrogenase E1 and transketolase domain containing 1 [Source:MGI Symbol;Acc:MGI:2445096]|Heterozygous||A|T|31|37.0|Non-synonymous|Unprocessed|APF-G1
1760152|IGL00777|13|55238735|G->E||1.0|Probably damaging||deleterious|MGI:1276545|Nsd1|nuclear receptor-binding SET-domain protein 1 [Source:MGI Symbol;Acc:MGI:1276545]|Heterozygous|Homozygotes for targeted null mutations exhibit excess apoptosis and retarded growth, fail to complete gastrulation, and are resorbed by embryonic day 10.|G|A|28|37.0|Non-synonymous|Unprocessed|APF-G1
1760153|IGL00777|1|161109755|T->A|||Benign|0.03|deleterious|MGI:2444855|Klhl20|kelch-like 20 (Drosophila) [Source:MGI Symbol;Acc:MGI:2444855]|Heterozygous||T|C|26|32.5|Non-synonymous|Unprocessed|APF-G1
1760154|IGL00777|7|128203850|T->S||0.89|Possibly damaging||deleterious|MGI:3578624|Itgad|integrin, alpha D [Source:MGI Symbol;Acc:MGI:3578624]|Heterozygous||A|T|20|36.5|Non-synonymous|Unprocessed|APF-G1
1760155|IGL00777|11|75390808|M->K|||Benign|1.0|tolerated|MGI:2442796|Smyd4|SET and MYND domain containing 4 [Source:MGI Symbol;Acc:MGI:2442796]|Heterozygous||T|A|16|39.0|Non-synonymous|Unprocessed|APF-G1
1760156|IGL00777|19|17395336|V->E|||Benign|1.0|tolerated|MGI:1914688|Rfk|riboflavin kinase [Source:MGI Symbol;Acc:MGI:1914688]|Heterozygous|Mice homozygous for a knock-out allele die in utero prior to E7.5.|T|A|16|40.0|Non-synonymous|Unprocessed|APF-G1
1760157|IGL00777|5|50025758|I->T||0.97|Probably damaging||deleterious|MGI:1917943|Gpr125|G protein-coupled receptor 125 [Source:MGI Symbol;Acc:MGI:1917943]|Heterozygous|Homozygous mutant mice are fertile and grossly normal.|A|G|14|38.0|Non-synonymous|Unprocessed|APF-G1
1760158|IGL00777|15|8019607|M->K||0.02|Benign||deleterious|MGI:1921020|Wdr70|WD repeat domain 70 [Source:MGI Symbol;Acc:MGI:1921020]|Heterozygous||A|T|13|39.0|Non-synonymous|Unprocessed|APF-G1
1760161|IGL00777|5|22018850|Disrupted splicing||||||MGI:103022|Reln|reelin [Source:MGI Symbol;Acc:MGI:103022]|Heterozygous|Homozygotes for most spontaneous or ENU-induced mutations show impaired righting responses, ataxia, tremors, and cerebellum and hippocampus abnormalities. Some mutants show postnatal or premature death and decreased body size while others have abnormal retinas or olfactory bulbs or infertility.|A|G|50|37.5|Splice|Unprocessed|APF-G1
1760634|IGL00778|X|58034419|Y->C||0.98|Probably damaging|0.05|tolerated|MGI:106676|Zic3|zinc finger protein of the cerebellum 3 [Source:MGI Symbol;Acc:MGI:106676]|Heterozygous|Mutants show incomplete penetrance varying by genetic background and allele. Phenotypes range from bent tail/skeletal abnormalities to severe defects in embryo turning, cardiac development and neural tube closure resulting in death at embryonic day 18.5|A|G|84|38.0|Non-synonymous|Unprocessed|APF-G1
1760635|IGL00778|11|84877324|I->T||0.01|Benign|0.02|deleterious|MGI:1917575|Pigw|phosphatidylinositol glycan anchor biosynthesis, class W [Source:MGI Symbol;Acc:MGI:1917575]|Heterozygous||A|G|64|39.0|Non-synonymous|Unprocessed|APF-G1
1760636|IGL00778|10|24798262|C->F||1.0|Probably damaging||deleterious|MGI:2143702|Enpp3|ectonucleotide pyrophosphatase/phosphodiesterase 3 [Source:MGI Symbol;Acc:MGI:2143702]|Heterozygous||C|A|44|41.0|Non-synonymous|Unprocessed|APF-G1
1760637|IGL00778|14|56674443|I->V|||Benign|0.68|tolerated|MGI:1922589|Mphosph8|M-phase phosphoprotein 8 [Source:MGI Symbol;Acc:MGI:1922589]|Heterozygous||A|G|43|37.0|Non-synonymous|Unprocessed|APF-G1
1760638|IGL00778|6|118126272|M->K|||Benign|0.3|tolerated|MGI:1926002|Csgalnact2|chondroitin sulfate N-acetylgalactosaminyltransferase 2 [Source:MGI Symbol;Acc:MGI:1926002]|Heterozygous||A|T|40|37.0|Non-synonymous|Unprocessed|APF-G1
1760639|IGL00778|10|85879888|V->A||0.04|Benign|0.22|tolerated|MGI:1914735|Pwp1|PWP1 homolog (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1914735]|Heterozygous||T|C|34|37.5|Non-synonymous|Unprocessed|APF-G1
1760640|IGL00778|3|106201797|S->P|||Benign|0.04|deleterious|MGI:1341098|Chi3l4|chitinase 3-like 4 [Source:MGI Symbol;Acc:MGI:1341098]|Heterozygous||A|G|31|40.0|Non-synonymous|Unprocessed|APF-G1
1760641|IGL00778|4|101096271|Q->K|||Benign|1.0|tolerated|MGI:2443623|Raver2|ribonucleoprotein, PTB-binding 2 [Source:MGI Symbol;Acc:MGI:2443623]|Heterozygous||C|A|31|38.0|Non-synonymous|Unprocessed|APF-G1
1760642|IGL00778|4|136339545|D->E|||Unknown|0.46|tolerated|MGI:1891692|Hnrnpr|heterogeneous nuclear ribonucleoprotein R [Source:MGI Symbol;Acc:MGI:1891692]|Heterozygous||T|A|29|37.0|Non-synonymous|Unprocessed|APF-G1
1760643|IGL00778|13|102705409|S->N|||Benign|0.99|tolerated|MGI:1194924|Cd180|CD180 antigen [Source:MGI Symbol;Acc:MGI:1194924]|Heterozygous|Mice homozygous for a null mutation showed impaired proliferative and humoral immune responses of B cells to lipopolysaccharides.|G|A|27|38.0|Non-synonymous|Unprocessed|APF-G1
1760644|IGL00778|1|189654912|C->S|||Benign|0.67|tolerated|MGI:1313302|Cenpf|centromere protein F [Source:MGI Symbol;Acc:MGI:1313302]|Heterozygous||A|T|26|36.5|Non-synonymous|Unprocessed|APF-G1
1760645|IGL00778|4|53086132|D->G|||Benign|0.85|tolerated|MGI:99607|Abca1|ATP-binding cassette, sub-family A (ABC1), member 1 [Source:MGI Symbol;Acc:MGI:99607]|Heterozygous|Many homozygous null mutants die perinatally with placental defects. Survivors show altered steroidogenesis, defective lipid export in Golgi, low serum cholesterol, lipid accumulation in macrophages and lung, reduced fertility and kidney and heart defects.|T|C|26|38.0|Non-synonymous|Unprocessed|APF-G1
1760646|IGL00778|12|64950066|D->E||1.0|Probably damaging|0.05|deleterious|MGI:1913939|Klhl28|kelch-like 28 (Drosophila) [Source:MGI Symbol;Acc:MGI:1913939]|Heterozygous||A|T|21|38.0|Non-synonymous|Unprocessed|APF-G1
1760647|IGL00778|13|64215656|N->D||1.0|Probably damaging||deleterious|MGI:2441808|Cdc14b|CDC14 cell division cycle 14 homolog B (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:2441808]|Heterozygous|Mice homozygous for a knock-out allele exhibit premature aging, including premature cataracts and kyphosis; reduced fertility, particularly in female mice; and impaired contextual conditioning.|T|C|20|40.0|Non-synonymous|Unprocessed|APF-G1
1760648|IGL00778|2|84993732|C->Y||1.0|Probably damaging||deleterious|MGI:1858200|Prg3|proteoglycan 3 [Source:MGI Symbol;Acc:MGI:1858200]|Heterozygous||G|A|20|37.5|Non-synonymous|Unprocessed|APF-G1
1760649|IGL00778|7|125667374|R->W||1.0|Probably damaging||deleterious|MGI:107887|Gtf3c1|general transcription factor III C 1 [Source:MGI Symbol;Acc:MGI:107887]|Heterozygous||G|A|17|36.0|Non-synonymous|Unprocessed|APF-G1
1760650|IGL00778|2|10402007|E->G||1.0|Probably damaging|0.09|tolerated|MGI:2447794|Sfmbt2|Scm-like with four mbt domains 2 [Source:MGI Symbol;Acc:MGI:2447794]|Heterozygous||A|G|15|38.0|Non-synonymous|Unprocessed|APF-G1
1760651|IGL00778|7|101778608|R->Stop|||N/A|||MGI:1100517|Clpb|ClpB caseinolytic peptidase B homolog (E. coli) [Source:MGI Symbol;Acc:MGI:1100517]|Heterozygous||C|T|15|38.0|Non-synonymous|Unprocessed|APF-G1
1760652|IGL00778|5|67659903|K->N||0.86|Possibly damaging|0.12|tolerated|MGI:1330848|Atp8a1|ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 [Source:MGI Symbol;Acc:MGI:1330848]|Heterozygous|Homozygous mutant mice are viable, fertile and phenotypically normal.|T|G|14|37.5|Non-synonymous|Unprocessed|APF-G1
1760653|IGL00778|4|140727623|I->L||0.22|Benign||deleterious|MGI:2655198|Padi6|peptidyl arginine deiminase, type VI [Source:MGI Symbol;Acc:MGI:2655198]|Heterozygous|Mice homozygous for a null allele exhibit altered oocyte cytoplasmic structures that lead to a failure of zygotes to progress beyond the 2 cell stage and female infertility.|T|A|12|38.0|Non-synonymous|Unprocessed|APF-G1
1760654|IGL00778|10|127909828|S->P||1.0|Probably damaging||deleterious|MGI:1917311|Sdr9c7|4short chain dehydrogenase/reductase family 9C, member 7 [Source:MGI Symbol;Acc:MGI:1917311]|Heterozygous||T|C|10|34.5|Non-synonymous|Unprocessed|APF-G1
1760655|IGL00778|14|44163934|H->Y||0.04|Benign|1.0|tolerated|MGI:1922204|4930503e14rik|RIKEN cDNA 4930503E14 gene [Source:MGI Symbol;Acc:MGI:1922204]|Heterozygous||G|A|10|34.5|Non-synonymous|Unprocessed|APF-G1
1760658|IGL00778|4|6435056|Disrupted splicing||||||MGI:1341864|Nsmaf|neutral sphingomyelinase (N-SMase) activation associated factor [Source:MGI Symbol;Acc:MGI:1341864]|Heterozygous|Mice homozygous for a targeted null mutation show no gross phenotypic abnormalities but display delayed cutaneous barrier repair.  In addition, D-galactosamine-sensitized homozygotes are partially resistant to LPS- and TNF-induced lethality.|C|T|95|40.0|Splice|Unprocessed|APF-G1
1760659|IGL00778|9|95973447|Disrupted splicing||||||MGI:891964|Xrn1|5'-3' exoribonuclease 1 [Source:MGI Symbol;Acc:MGI:891964]|Heterozygous||T|C|92|40.0|Splice|Unprocessed|APF-G1
1760660|IGL00778|11|106171150|Disrupted splicing||||||MGI:1919399|Strada|STE20-related kinase adaptor alpha [Source:MGI Symbol;Acc:MGI:1919399]|Heterozygous||A|G|24|35.0|Splice|Unprocessed|APF-G1
1760661|IGL00778|14|101910885|Disrupted splicing||||||MGI:1353586|Lmo7|LIM domain only 7 [Source:MGI Symbol;Acc:MGI:1353586]|Heterozygous|Targeted mutations in this gene result in postnatal lethality, growth defects, skeletal muscle abnormalities and retinal defects reflective of retinal degeneration.|C|T|23|39.0|Splice|Unprocessed|APF-G1
1760662|IGL00778|9|80283586|Disrupted splicing||||||MGI:104785|Myo6|myosin VI [Source:MGI Symbol;Acc:MGI:104785]|Heterozygous|Homozygous mutant mice exhibit deafness and related behavioral characteristics such as circling, head tossing and hyperactivity.  Progressive degeneration of the cochlear hair cells and the organ of Corti is observed with one mutation.|T|A|19|39.0|Splice|Unprocessed|APF-G1
1761104|IGL00779|8|91078921|W->Stop|||N/A|||MGI:105085|Rbl2|retinoblastoma-like 2 [Source:MGI Symbol;Acc:MGI:105085]|Heterozygous|Homozygotes for targeted null mutations exhibit arrested embryonic growth and varying disorganization in neural and dermamyotome structures, with death by embryonic day 11-13. On a different background mutants were viable and fertile.|G|A|187|39.0|Non-synonymous|Unprocessed|APF-G1
1761105|IGL00779|4|56813204|S->T||0.13|Benign|0.26|tolerated|MGI:1859649|Ctnnal1|catenin (cadherin associated protein), alpha-like 1 [Source:MGI Symbol;Acc:MGI:1859649]|Heterozygous||A|T|109|39.0|Non-synonymous|Unprocessed|APF-G1
1761106|IGL00779|X|84773667|G->D||0.51|Possibly damaging|0.34|tolerated|MGI:94909|Dmd|dystrophin, muscular dystrophy [Source:MGI Symbol;Acc:MGI:94909]|Heterozygous|Hemizygous males and homozygous mutant females show progressive muscle atrophy, increased K+ and Ca+ in muscle with age, increased blood pyruvate kinase and other symptoms of Duchenne and Becker muscular dystrophy. Alleles vary in severity and may include cardiovascular and digestive system defects.|G|A|99|39.0|Non-synonymous|Unprocessed|APF-G1
1761107|IGL00779|7|92040846|Q->H||0.23|Benign|0.13|tolerated|MGI:1344351|Dlg2|discs, large homolog 2 (Drosophila) [Source:MGI Symbol;Acc:MGI:1344351]|Heterozygous|Mice homozygous for a knock-out allele display lower surface expression of NMDA receptor (NMDAR) subunits NR2A and NR2B in dorsal horn neurons and significantly reduced NMDAR-mediated excitatory synaptic currents and NMDAR-dependent persistent inflammatory or nerve injury-induced neuropathic pain.|A|C|88|39.0|Non-synonymous|Unprocessed|APF-G1
1761108|IGL00779|14|52212890|S->G|||Benign|0.31|tolerated|MGI:1915022|Chd8|chromodomain helicase DNA binding protein 8 [Source:MGI Symbol;Acc:MGI:1915022]|Heterozygous|Homozygous null embryos are growth retarded starting at E5.5 and exhibit developmental arrest at E6.5.  Mutants develop into an egg cylinder but do not form a primitive streak or mesoderm and exhibit increased apoptosis at E7.5.|T|C|77|38.0|Non-synonymous|Unprocessed|APF-G1
1761109|IGL00779|14|52159431|D->G||1.0|Probably damaging|||MGI:1932134|Rpgrip1|retinitis pigmentosa GTPase regulator interacting protein 1 [Source:MGI Symbol;Acc:MGI:1932134]|Heterozygous|Homozygous mutation of this gene results in photoreceptor cell dysmorphology. By 3 months of age mutant animals show near complete loss of photoreceptor cells.|A|G|73|38.0|Non-synonymous|Unprocessed|APF-G1
1761110|IGL00779|17|17892886|I->S||1.0|Probably damaging||deleterious|MGI:1278319|Fpr2|formyl peptide receptor 2 [Source:MGI Symbol;Acc:MGI:1278319]|Heterozygous|Mice homozygous for a targeted reporter allele exhibit altered leukocyte responses and experimentally induced inflammation.|T|G|65|39.0|Non-synonymous|Unprocessed|APF-G1
1761111|IGL00779|17|85023714|S->T||||0.2|tolerated|MGI:101841|Ppm1b|protein phosphatase 1B, magnesium dependent, beta isoform [Source:MGI Symbol;Acc:MGI:101841]|Heterozygous|Homozygous mutation of this gene results in early pre-implantation lethality.|T|A|57|36.0|Non-synonymous|Unprocessed|APF-G1
1761112|IGL00779|9|110376631|V->A||0.99|Probably damaging|0.03|deleterious|MGI:2135958|Scap|SREBF chaperone [Source:MGI Symbol;Acc:MGI:2135958]|Heterozygous||T|C|55|37.0|Non-synonymous|Unprocessed|APF-G1
1761113|IGL00779|19|45778677|K->E||0.55|Possibly damaging|0.1|tolerated|MGI:1932139|Mgea5|meningioma expressed antigen 5 (hyaluronidase) [Source:MGI Symbol;Acc:MGI:1932139]|Heterozygous||T|C|49|39.0|Non-synonymous|Unprocessed|APF-G1
1761114|IGL00779|2|128794524|D->G||0.99|Probably damaging|0.01|deleterious|MGI:96965|Mertk|c-mer proto-oncogene tyrosine kinase [Source:MGI Symbol;Acc:MGI:96965]|Heterozygous|Homozygotes for targeted null mutations show increased sensitivity to LPS-induced shock, defective phagocytosis of apoptotic cells, lupus-like autoimmunity, degeneration of photoreceptors, decreased platelet aggregation and protection from induced pulmonary thromboembolism and thrombosis.|A|G|49|37.0|Non-synonymous|Unprocessed|APF-G1
1761115|IGL00779|1|72339046|R->S||0.05|Benign|0.48|tolerated|MGI:104517|Xrcc5|X-ray repair complementing defective repair in Chinese hamster cells 5 [Source:MGI Symbol;Acc:MGI:104517]|Heterozygous|Mutants are defective in DNA double-strand break repair and show impaired growth and severe combined immunodeficiency due to defective assembly of TCRs and immunoglobulins. Mutants die early with osteopenia, atrophic skin and hepatic abnormalities.|A|T|44|37.5|Non-synonymous|Unprocessed|APF-G1
1761116|IGL00779|1|54547976|V->A||1.0|Probably damaging|0.02|deleterious|MGI:2443342|Pgap1|post-GPI attachment to proteins 1 [Source:MGI Symbol;Acc:MGI:2443342]|Heterozygous|Mutations in this gene result in a variety of forebrain, eye, jaw, craniofacial, ear, and vertebra defects that are background sensitive.|A|G|43|37.0|Non-synonymous|Unprocessed|APF-G1
1761117|IGL00779|X|48124664|N->D||0.85|Possibly damaging|0.43|tolerated|MGI:2180001|Xpnpep2|X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound [Source:MGI Symbol;Acc:MGI:2180001]|Heterozygous||A|G|37|36.0|Non-synonymous|Unprocessed|APF-G1
1761118|IGL00779|6|106678397|E->Stop|||N/A|||MGI:1095737|Cntn4|contactin 4 [Source:MGI Symbol;Acc:MGI:1095737]|Heterozygous|Mice homozygous for a knock-out allele exhibit aberrant projection of olfactory axons to multiple glomeruli in the olfactory bulb.|G|T|36|39.0|Non-synonymous|Unprocessed|APF-G1
1761119|IGL00779|1|188951533|T->A||0.88|Possibly damaging|0.05|tolerated|MGI:1341292|Ush2a|Usher syndrome 2A (autosomal recessive, mild) homolog (human) [Source:MGI Symbol;Acc:MGI:1341292]|Heterozygous|Mice homozygous for a knock-out allele display progressive retinal photoreceptor degeneration along with significantly reduced a- and b-wave amplitudes, and a moderate but nonprogressive high-frequency hearing loss associated with widespread loss of outer hair cells in the basal turn of the cochlea.|A|G|33|34.0|Non-synonymous|Unprocessed|APF-G1
1761120|IGL00779|9|110549879|S->P||0.76|Possibly damaging|0.01|deleterious|MGI:1918177|Setd2|SET domain containing 2 [Source:MGI Symbol;Acc:MGI:1918177]|Heterozygous|Mice homozygous for a knock-out allele exhibit impaired embryonic vascular remodeling in the embryo proper, yolk sac, and placenta that leads to death around E10.5.|T|C|33|39.0|Non-synonymous|Unprocessed|APF-G1
1761121|IGL00779|15|91321631|V->A||0.06|Benign|0.17|tolerated|MGI:2146030|Slc2a13|solute carrier family 2 (facilitated glucose transporter), member 13 [Source:MGI Symbol;Acc:MGI:2146030]|Heterozygous||A|G|32|39.5|Non-synonymous|Unprocessed|APF-G1
1761122|IGL00779|14|55973092|D->N|||Benign|0.64|tolerated|MGI:88426|Cma2|chymase 2, mast cell [Source:MGI Symbol;Acc:MGI:88426]|Heterozygous||G|A|30|38.0|Non-synonymous|Unprocessed|APF-G1
1761123|IGL00779|11|53883740|W->R||1.0|Probably damaging||deleterious|MGI:1329012|Slc22a5|solute carrier family 22 (organic cation transporter), member 5 [Source:MGI Symbol;Acc:MGI:1329012]|Heterozygous|Homozygotes for a spontaneous missense mutation exhibit systemic carnitine deficiency, cardiac hypertrophy, impaired Na-dependent carnitine transport, fatty liver, hypoglycemia, high postnatal mortality, and male infertility.|A|G|29|37.0|Non-synonymous|Unprocessed|APF-G1
1761124|IGL00779|17|80144980|V->I||0.68|Possibly damaging|0.24|tolerated|MGI:2442420|Galm|galactose mutarotase [Source:MGI Symbol;Acc:MGI:2442420]|Heterozygous||G|A|29|38.0|Non-synonymous|Unprocessed|APF-G1
1761125|IGL00779|6|29152351|V->A||0.01|Benign|0.75|tolerated|MGI:2655711|Rbm28|RNA binding motif protein 28 [Source:MGI Symbol;Acc:MGI:2655711]|Heterozygous||A|G|29|37.0|Non-synonymous|Unprocessed|APF-G1
1761126|IGL00779|10|12682369|R->C||1.0|Probably damaging||deleterious|MGI:104631|Utrn|utrophin [Source:MGI Symbol;Acc:MGI:104631]|Heterozygous|Homozygous null mutants have reduced density of acetylcholine receptors and reduced number of junctional folds at neuromuscular junctions. Mice homozygous for utrophin and dystrophin knockouts die prematurely with severe, progressive muscular dystrophy.|G|A|27|33.0|Non-synonymous|Unprocessed|APF-G1
1761127|IGL00779|11|103828500|N->D|||Benign|0.67|tolerated|MGI:104560|Nsf|N-ethylmaleimide sensitive fusion protein [Source:MGI Symbol;Acc:MGI:104560]|Heterozygous||T|C|26|35.0|Non-synonymous|Unprocessed|APF-G1
1761128|IGL00779|8|46524956|C->F|||Benign|0.64|tolerated|MGI:102797|Acsl1|acyl-CoA synthetase long-chain family member 1 [Source:MGI Symbol;Acc:MGI:102797]|Heterozygous|iver acyl-CoA levels are reduced when this gene is conditionally knocked out in the liver.|G|T|26|40.0|Non-synonymous|Unprocessed|APF-G1
1761129|IGL00779|11|108440536|S->Stop|||N/A|||MGI:1923673|Ccdc46|coiled-coil domain containing 46 [Source:MGI Symbol;Acc:MGI:1923673]|Heterozygous||C|A|25|37.0|Non-synonymous|Unprocessed|APF-G1
1761130|IGL00779|2|11743708|V->A|||Benign|0.61|tolerated|MGI:1354699|Fbxo18|F-box protein 18 [Source:MGI Symbol;Acc:MGI:1354699]|Heterozygous||A|G|25|36.0|Non-synonymous|Unprocessed|APF-G1
1761131|IGL00779|19|18792906|Q->Stop|||N/A|||MGI:2675603|Trpm6|transient receptor potential cation channel, subfamily M, member 6 [Source:MGI Symbol;Acc:MGI:2675603]|Heterozygous||C|T|20|38.5|Non-synonymous|Unprocessed|APF-G1
1761132|IGL00779|10|63136015|I->L||0.03|Benign|0.63|tolerated|MGI:1916052|Mypn|myopalladin [Source:MGI Symbol;Acc:MGI:1916052]|Heterozygous||T|G|19|38.0|Non-synonymous|Unprocessed|APF-G1
1761133|IGL00779|4|133185751|R->G|||Unknown|0.01|deleterious|MGI:1098641|Wasf2|WAS protein family, member 2 [Source:MGI Symbol;Acc:MGI:1098641]|Heterozygous|Homozygous mutants show impaired embryonic development and do not survive to term. In addition to reduced embryo size, observed defects include hemorrhaging, abnormal somite development, perturbed angiogenesis, and shrunken cerebral ventricles.|A|G|18|37.0|Non-synonymous|Unprocessed|APF-G1
1761134|IGL00779|1|151457819|Y->C|||Benign|0.2|tolerated|MGI:1916185|1190005f20rik|RIKEN cDNA 1190005F20 gene [Source:MGI Symbol;Acc:MGI:1916185]|Heterozygous|Mice homozygous for a gene trapped allele are viable and anatomically normal but display significantly impaired motor coordination and aberrant exploratory behavior.|A|G|14|37.5|Non-synonymous|Unprocessed|APF-G1
1761135|IGL00779|5|86709474|N->Y||1.0|Probably damaging||deleterious|MGI:3513175|Tmprss11e|transmembrane protease, serine 11e [Source:MGI Symbol;Acc:MGI:3513175]|Heterozygous||T|A|11|34.0|Non-synonymous|Unprocessed|APF-G1
1761138|IGL00779|2|112410240|Disrupted splicing||||||MGI:1919675|2410042d21rik|RIKEN cDNA 2410042D21 gene [Source:MGI Symbol;Acc:MGI:1919675]|Heterozygous||A|G|214|39.0|Splice|Unprocessed|APF-G1
1761139|IGL00779|18|20108936|Disrupted splicing||||||MGI:109173|Dsc1|desmocollin 1 [Source:MGI Symbol;Acc:MGI:109173]|Heterozygous|Mutants with targeted disruptions of this gene have fragile epidermis, flaky skin, and defects in the epidermal barrier, leading to chronic dermatitis and display abnormal epidermal differentiation as indicated by hyperproliferation and overxpression of keratin 6 and 16.|A|G|144|38.5|Splice|Unprocessed|APF-G1
1761140|IGL00779|8|24744113|Disrupted splicing||||||MGI:104730|Adam5|a disintegrin and metallopeptidase domain 5 [Source:MGI Symbol;Acc:MGI:104730]|Heterozygous||A|G|37|32.0|Splice|Unprocessed|APF-G1
1761141|IGL00779|7|121094675|Disrupted splicing||||||MGI:2149209|Otoa|otoancorin [Source:MGI Symbol;Acc:MGI:2149209]|Heterozygous||T|A|16|39.5|Splice|Unprocessed|APF-G1
1761605|IGL00780|5|122344247|I->V|||Benign|0.73|tolerated|MGI:2385231|Rad9b|RAD9 homolog B (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:2385231]|Heterozygous|Mice homozygous for a knock-out allele exhibit embryonic lethality, decreased forebrain and somite cell proliferation, and increased cellular sensitivity to gamma irradiation and mitomycin C. Mice heterozygous for a knock-out allele exhibit reduced embryonic, fetal, and early postnatal survival.|T|C|110|39.0|Non-synonymous|Unprocessed|APF-G1
1761606|IGL00780|5|12524326|R->Q||1.0|Probably damaging|0.06|tolerated|MGI:1860118|Sema3d|sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D [Source:MGI Symbol;Acc:MGI:1860118]|Heterozygous||G|A|87|40.0|Non-synonymous|Unprocessed|APF-G1
1761607|IGL00780|2|69732924|E->D||0.04|Benign|0.03|deleterious|MGI:2445173|Ppig|peptidyl-prolyl isomerase G (cyclophilin G) [Source:MGI Symbol;Acc:MGI:2445173]|Heterozygous||A|T|80|39.0|Non-synonymous|Unprocessed|APF-G1
1761608|IGL00780|5|25311051|T->I||0.15|Benign|0.2|tolerated|MGI:2444959|Mll3|myeloid/lymphoid or mixed-lineage leukemia 3 [Source:MGI Symbol;Acc:MGI:2444959]|Heterozygous|Mice homozygous for a knock-out allele display partial embryonic lethality, delayed eyelid opening, postnatal growth retardation, impaired fertility in both sexes, and decreased proliferation of cultured mouse embryonic fibroblasts.|G|A|62|39.0|Non-synonymous|Unprocessed|APF-G1
1761609|IGL00780|12|99893648|V->A||0.45|Possibly damaging|0.23|tolerated|MGI:1920036|Tdp1|tyrosyl-DNA phosphodiesterase 1 [Source:MGI Symbol;Acc:MGI:1920036]|Heterozygous|Mice homozygous for a null allele exhibit defective single strand DNA repair in neurons, decreased cerebellum size and increased sensitivity to topotecan.|T|C|59|40.0|Non-synonymous|Unprocessed|APF-G1
1761610|IGL00780|13|112851506|I->M||0.98|Probably damaging||deleterious|MGI:108412|Ppap2a|phosphatidic acid phosphatase type 2A [Source:MGI Symbol;Acc:MGI:108412]|Heterozygous|Mice homozygous for a hypomorphic allele are viable and fertile with elevated plasma levels of lysophosphatidic acid.|A|G|54|38.0|Non-synonymous|Unprocessed|APF-G1
1761611|IGL00780|13|100479221|D->G|||Benign|0.51|tolerated|MGI:1345669|Gtf2h2|general transcription factor II H, polypeptide 2 [Source:MGI Symbol;Acc:MGI:1345669]|Heterozygous||T|C|52|39.0|Non-synonymous|Unprocessed|APF-G1
1761612|IGL00780|5|45747295|N->S||0.89|Possibly damaging|0.56|tolerated|MGI:2651932|Lcorl|ligand dependent nuclear receptor corepressor-like [Source:MGI Symbol;Acc:MGI:2651932]|Heterozygous||T|C|51|39.0|Non-synonymous|Unprocessed|APF-G1
1761613|IGL00780|16|56602805|D->G||0.9|Possibly damaging|0.07|tolerated|MGI:2444583|Abi3bp|ABI gene family, member 3 (NESH) binding protein [Source:MGI Symbol;Acc:MGI:2444583]|Heterozygous||A|G|40|39.0|Non-synonymous|Unprocessed|APF-G1
1761614|IGL00780|2|64914718|P->S||0.94|Possibly damaging||deleterious|MGI:1355324|Grb14|growth factor receptor bound protein 14 [Source:MGI Symbol;Acc:MGI:1355324]|Heterozygous|Homozygous mutation of this gene results in improved glucose tolerance, lower circulating insulin levels and increased incorporation of glucose into glycogen in the liver and skeletal muscle of males. Both males and females exhibit a decrease in body size.|G|A|40|39.0|Non-synonymous|Unprocessed|APF-G1
1761615|IGL00780|4|116603999|E->Stop|||N/A|||MGI:1355328|Nasp|nuclear autoantigenic sperm protein (histone-binding) [Source:MGI Symbol;Acc:MGI:1355328]|Heterozygous|Mice homozygous for a null mutation display embryonic lethality before implantation.|C|A|38|38.0|Non-synonymous|Unprocessed|APF-G1
1761616|IGL00780|7|144655630|S->P||1.0|Probably damaging|0.01|deleterious|MGI:2142149|Ano1|anoctamin 1, calcium activated chloride channel [Source:MGI Symbol;Acc:MGI:2142149]|Heterozygous|Mice homozygous for a knockout allele exhibit postnatal death associated with aerophagia, slow postnatal weight gain, cyanosis, and abnormal tracheal morphology.|A|G|36|35.0|Non-synonymous|Unprocessed|APF-G1
1761617|IGL00780|16|33884975|V->I||1.0|Probably damaging|0.23|tolerated|MGI:96614|Itgb5|integrin beta 5 [Source:MGI Symbol;Acc:MGI:96614]|Heterozygous|Homozygotes for a targeted null mutation do not appear to differ from normal in respect to development, reproduction, adenovirus infection, or wound healing. Mutant keratinocytes do show reduced migration on, and adhesion to, vitronectin in vitro.|G|A|35|37.0|Non-synonymous|Unprocessed|APF-G1
1761618|IGL00780|7|7133114|Q->L||0.92|Possibly damaging|0.38|tolerated|MGI:1923623|Zfp773|zinc finger protein 773 [Source:MGI Symbol;Acc:MGI:1923623]|Heterozygous||T|A|35|39.0|Non-synonymous|Unprocessed|APF-G1
1761619|IGL00780|3|54302175|P->S||1.0|Probably damaging||deleterious|MGI:109525|Trpc4|transient receptor potential cation channel, subfamily C, member 4 [Source:MGI Symbol;Acc:MGI:109525]|Heterozygous|Homozygous null mice exhibit a significant reduction in agonist-induced Ca2+ entry and vasorelaxation of aortic rings.|C|T|33|36.0|Non-synonymous|Unprocessed|APF-G1
1761620|IGL00780|18|58095988|T->A||1.0|Probably damaging|0.01|deleterious|MGI:95490|Fbn2|fibrillin 2 [Source:MGI Symbol;Acc:MGI:95490]|Heterozygous|Homozygotes for spontaneous, chemically-induced, and targeted null mutations show bilateral syndactyly with fusion of both soft and hard tissues. Deafness found in an X-ray induced allelic mutant is apparently due to the joint disruption of a linked gene.|T|C|32|37.0|Non-synonymous|Unprocessed|APF-G1
1761621|IGL00780|19|40934446|K->M|||Benign|0.01|deleterious|MGI:96878|Blnk|B-cell linker [Source:MGI Symbol;Acc:MGI:96878]|Heterozygous|Homozygotes for targeted null mutations exhibit a partial block in pre-B cell development, a lack of B1 B cells, reduced numbers of mature B cells, lower IgM and IgG3 serum levels, poor IgM immune responses, and a high incidence of pre-B cell lymphoma.|T|A|31|38.0|Non-synonymous|Unprocessed|APF-G1
1761622|IGL00780|9|88841856|D->V||0.38|Benign|0.13|tolerated|MGI:3647365|Trim43c|tripartite motif-containing 43C [Source:MGI Symbol;Acc:MGI:3647365]|Heterozygous||A|T|31|38.0|Non-synonymous|Unprocessed|APF-G1
1761623|IGL00780|7|41480459|Y->C||1.0|Probably damaging||deleterious|MGI:2142212|Aw146154|expressed sequence AW146154 [Source:MGI Symbol;Acc:MGI:2142212]|Heterozygous||T|C|26|39.5|Non-synonymous|Unprocessed|APF-G1
1761624|IGL00780|15|83138479|G->R||1.0|Probably damaging|0.06|tolerated|MGI:1921076|Poldip3|polymerase (DNA-directed), delta interacting protein 3 [Source:MGI Symbol;Acc:MGI:1921076]|Heterozygous||C|T|25|35.0|Non-synonymous|Unprocessed|APF-G1
1761625|IGL00780|7|101778608|R->Stop|||N/A|||MGI:1100517|Clpb|ClpB caseinolytic peptidase B homolog (E. coli) [Source:MGI Symbol;Acc:MGI:1100517]|Heterozygous||C|T|24|35.5|Non-synonymous|Unprocessed|APF-G1
1761626|IGL00780|14|97901422|N->K||0.31|Benign|0.11|tolerated|MGI:1277991|Dach1|dachshund 1 (Drosophila) [Source:MGI Symbol;Acc:MGI:1277991]|Heterozygous|In spite of normal gross morphology, mice homozygous for targeted mutations that inactivate this gene die within 1 day of birth.|A|T|23|39.0|Non-synonymous|Unprocessed|APF-G1
1761627|IGL00780|3|131193130|F->L||0.04|Benign|0.12|tolerated|MGI:96770|Lef1|lymphoid enhancer binding factor 1 [Source:MGI Symbol;Acc:MGI:96770]|Heterozygous|Homozygotes for targeted null mutations lack teeth, mammary glands, hair, dentate gyrus granule cells, and submucosal glands, and die postnatally. Mutants' pro-B cells exhibit defects in proliferation and survival.|T|C|23|35.0|Non-synonymous|Unprocessed|APF-G1
1761628|IGL00780|12|108815537|I->S||1.0|Probably damaging|0.01|deleterious|MGI:99150|Yy1|YY1 transcription factor [Source:MGI Symbol;Acc:MGI:99150]|Heterozygous|Homozygous null mice die in utero shortly after implantation. Incomplete penetrance of embryonic growth retardation and exencephaly are observed in haploinsufficient mice.|T|G|22|35.5|Non-synonymous|Unprocessed|APF-G1
1761629|IGL00780|2|33273627|H->Q||1.0|Probably damaging||deleterious|MGI:1922008|Ralgps1|Ral GEF with PH domain and SH3 binding motif 1 [Source:MGI Symbol;Acc:MGI:1922008]|Heterozygous||A|T|22|40.0|Non-synonymous|Unprocessed|APF-G1
1761630|IGL00780|3|122549249|D->G||0.7|Possibly damaging|0.04|deleterious|MGI:1925642|Fnbp1l|formin binding protein 1-like [Source:MGI Symbol;Acc:MGI:1925642]|Heterozygous||T|C|22|36.0|Non-synonymous|Unprocessed|APF-G1
1761631|IGL00780|5|9422367|T->A||0.94|Possibly damaging|0.01|deleterious|MGI:2443264|9330182l06rik|RIKEN cDNA 9330182L06 gene [Source:MGI Symbol;Acc:MGI:2443264]|Heterozygous||A|G|22|33.5|Non-synonymous|Unprocessed|APF-G1
1761632|IGL00780|14|74706205|L->F||0.91|Possibly damaging|0.06|tolerated|MGI:109521|Htr2a|5-hydroxytryptamine (serotonin) receptor 2A [Source:MGI Symbol;Acc:MGI:109521]|Heterozygous||A|T|20|39.5|Non-synonymous|Unprocessed|APF-G1
1761633|IGL00780|16|17653487|T->I||0.98|Probably damaging||deleterious|MGI:2137379|Med15|mediator complex subunit 15 [Source:MGI Symbol;Acc:MGI:2137379]|Heterozygous||G|A|19|38.0|Non-synonymous|Unprocessed|APF-G1
1761634|IGL00780|17|45569564|N->S||0.99|Probably damaging|0.02|deleterious|MGI:96247|Hsp90ab1|heat shock protein 90 alpha (cytosolic), class B member 1 [Source:MGI Symbol;Acc:MGI:96247]|Heterozygous|Homozygotes for a gene-trapped null mutation exhibit placental defects including failure to form a placental labyrinth and lack of expansion of allantoic blood vessels. Mutants die around mid-gestation.|T|C|17|39.0|Non-synonymous|Unprocessed|APF-G1
1761635|IGL00780|6|48987739|D->G||0.34|Benign|0.01|deleterious|MGI:2682321|Svs1|seminal vesicle secretory protein 1 [Source:MGI Symbol;Acc:MGI:2682321]|Heterozygous||A|G|16|38.0|Non-synonymous|Unprocessed|APF-G1
1761636|IGL00780|12|98680371|T->K|||||deleterious|MGI:1344406|Ptpn21|protein tyrosine phosphatase, non-receptor type 21 [Source:MGI Symbol;Acc:MGI:1344406]|Heterozygous||G|T|15|40.0|Non-synonymous|Unprocessed|APF-G1
1761637|IGL00780|9|108209619|W->R||0.94|Possibly damaging||deleterious|MGI:101864|Dag1|dystroglycan 1 [Source:MGI Symbol;Acc:MGI:101864]|Heterozygous|Homozygous null mutant embryos show gross abnormalities, particularly defective Reichert's membrane by 6.5 days, indicating a possible role for this gene product in basement membrane organization.|A|T|12|38.0|Non-synonymous|Unprocessed|APF-G1
1761638|IGL00780|11|119274291|L->Stop|||N/A|||MGI:95609|Gaa|glucosidase, alpha, acid [Source:MGI Symbol;Acc:MGI:95609]|Heterozygous||T|A|11|39.0|Non-synonymous|Unprocessed|APF-G1
1761639|IGL00780|2|21826818|K->Stop|||N/A|||MGI:2441697|Gpr158|G protein-coupled receptor 158 [Source:MGI Symbol;Acc:MGI:2441697]|Heterozygous||A|T|11|39.0|Non-synonymous|Unprocessed|APF-G1
1761640|IGL00780|8|88170940|I->V|||Benign|0.3|tolerated|MGI:2444491|Heatr3|HEAT repeat containing 3 [Source:MGI Symbol;Acc:MGI:2444491]|Heterozygous||A|G|11|38.0|Non-synonymous|Unprocessed|APF-G1
1761641|IGL00780|15|101137367|F->Y||1.0|Probably damaging|0.13|tolerated|MGI:1338946|Acvrl1|activin A receptor, type II-like 1 [Source:MGI Symbol;Acc:MGI:1338946]|Heterozygous|Mice homozygous for targeted mutations that inactivate the gene die at midgestation with severe vascular abnormalities, including fusion of major arteries and veins.  Mice heterozygous for one targeted mutation provide a suitable model for hereditary hemorrhagic telangiectasia type 2.|T|A|10|35.0|Non-synonymous|Unprocessed|APF-G1
1761645|IGL00780|9|63281077|Disrupted splicing||||||MGI:1346345|Map2k5|mitogen-activated protein kinase kinase 5 [Source:MGI Symbol;Acc:MGI:1346345]|Heterozygous|Homozygous mutants die at E10.5 and exhibit abnormal cardiac development and a decrease in proliferation and an increase in apoptosis in the heart, head, and dorsal regions of the embryo.|T|C|42|34.0|Splice|Unprocessed|APF-G1
1761646|IGL00780|10|127875092|Disrupted splicing||||||MGI:3583955|Bc089597|cDNA sequence BC089597 [Source:MGI Symbol;Acc:MGI:3583955]|Heterozygous||T|C|41|37.0|Splice|Unprocessed|APF-G1
1761647|IGL00780|3|90190849|Disrupted splicing||||||MGI:1924845|Nup210l|nucleoporin 210-like [Source:MGI Symbol;Acc:MGI:1924845]|Heterozygous|Mice homozygous for a transgene insertion exhibit male infertility, asthenozoospermia, teratozoospermia, azoospermia, and seminiferous tubule degeneration.|A|T|34|40.0|Splice|Unprocessed|APF-G1
1761648|IGL00780|7|140945351|Disrupted splicing||||||MGI:2444047|Athl1|ATH1, acid trehalase-like 1 (yeast) [Source:MGI Symbol;Acc:MGI:2444047]|Heterozygous||T|C|11|38.0|Splice|Unprocessed|APF-G1
1762124|IGL00781|13|81578230|L->F||0.06|Benign|0.25|tolerated|MGI:1274784|Gpr98|G protein-coupled receptor 98 [Source:MGI Symbol;Acc:MGI:1274784]|Heterozygous|Homozygotes for a spontaneous and a targeted mutation exhibit high sensitivity to audiogenic seizures. Targeted mutant mice lack the ankle links that connect growing stereocilia in the developing cochlear hair cells.|G|A|87|38.0|Non-synonymous|Unprocessed|APF-G1
1762125|IGL00781|10|93232416|Y->C||1.0|Probably damaging||deleterious|MGI:97517|Cdk17|cyclin-dependent kinase 17 [Source:MGI Symbol;Acc:MGI:97517]|Heterozygous||A|G|57|37.0|Non-synonymous|Unprocessed|APF-G1
1762126|IGL00781|18|71809195|S->P||0.21|Benign|0.06|tolerated|MGI:94869|Dcc|deleted in colorectal carcinoma [Source:MGI Symbol;Acc:MGI:94869]|Heterozygous|Homozygous animals show defects in axonal projections and hypothalamic development affecting both visual and neruoendocrine systems.|A|G|48|38.5|Non-synonymous|Unprocessed|APF-G1
1762127|IGL00781|5|34613358|H->R||1.0|Probably damaging|0.02|deleterious|MGI:87918|Add1|adducin 1 (alpha) [Source:MGI Symbol;Acc:MGI:87918]|Heterozygous|Targeted gene deletion leads to reduced growth and compensated hemolytic anemia. RBCs are osmotically fragile, dehydrated, and spherocytic with severe loss of membrane surface area and reduced MCV. ~50% of homozygotes develop lethal hydrocephaly with dilation of the lateral, 3rd, and 4th ventricles.|A|G|46|39.0|Non-synonymous|Unprocessed|APF-G1
1762128|IGL00781|10|106966026|S->P||||0.33|tolerated|MGI:2685720|Acss3|acyl-CoA synthetase short-chain family member 3 [Source:MGI Symbol;Acc:MGI:2685720]|Heterozygous||A|G|44|37.5|Non-synonymous|Unprocessed|APF-G1
1762129|IGL00781|2|126919720|N->I||0.34|Benign|0.07|tolerated|MGI:1913802|2010106g01rik|RIKEN cDNA 2010106G01 gene [Source:MGI Symbol;Acc:MGI:1913802]|Heterozygous||T|A|44|37.0|Non-synonymous|Unprocessed|APF-G1
1762130|IGL00781|12|76024062|P->T|||Benign|1.0|tolerated|MGI:2449316|Syne2|synaptic nuclear envelope 2 [Source:MGI Symbol;Acc:MGI:2449316]|Heterozygous|Homozygotes for one knock-out allele show normal myonuclear positioning of both synaptic and non-synaptic nuclei in skeletal muscle cells. Homozygotes for another knock-out allele exhibit a thickened epidermis and altered nuclear envelope architecture in primary dermal fibroblasts and keratinocytes.|C|A|42|37.0|Non-synonymous|Unprocessed|APF-G1
1762131|IGL00781|16|13125369|V->A||0.97|Probably damaging|0.01|deleterious|MGI:1354163|Ercc4|excision repair cross-complementing rodent repair deficiency, complementation group 4 [Source:MGI Symbol;Acc:MGI:1354163]|Heterozygous|Homozygous null mice show impaired growth and do not survive longer than several weeks of age. Cultutred cells obtained from mutant mice were shown to be hypersensitive to UV irradiation.|T|C|36|40.0|Non-synonymous|Unprocessed|APF-G1
1762132|IGL00781|15|93254392|R->H||1.0|Probably damaging|0.04|deleterious|MGI:2684933|Gxylt1|glucoside xylosyltransferase 1 [Source:MGI Symbol;Acc:MGI:2684933]|Heterozygous||C|T|34|34.0|Non-synonymous|Unprocessed|APF-G1
1762133|IGL00781|11|58990697|L->P|||Benign|0.16|tolerated|MGI:2137355|Trim11|tripartite motif-containing 11 [Source:MGI Symbol;Acc:MGI:2137355]|Heterozygous||T|C|28|35.0|Non-synonymous|Unprocessed|APF-G1
1762134|IGL00781|7|139987245|N->K||1.0|Probably damaging||deleterious|MGI:107825|Adam8|a disintegrin and metallopeptidase domain 8 [Source:MGI Symbol;Acc:MGI:107825]|Heterozygous|Homozygous mutant mice do not exhibit any morphological or pathological abnormalities. Mice homozygous for a different knock-out allele exhibit reduced osteoclast differentiation and calvarial fibrosis in response to TNF-alpha treatment.|A|T|27|40.0|Non-synonymous|Unprocessed|APF-G1
1762135|IGL00781|13|97149339|F->S||0.96|Probably damaging||deleterious|MGI:2444783|Gfm2|G elongation factor, mitochondrial 2 [Source:MGI Symbol;Acc:MGI:2444783]|Heterozygous||T|C|26|37.0|Non-synonymous|Unprocessed|APF-G1
1762136|IGL00781|7|83947280|I->T||1.0|Probably damaging||deleterious|MGI:2443629|9930013l23rik|RIKEN cDNA 9930013L23 gene [Source:MGI Symbol;Acc:MGI:2443629]|Heterozygous||A|G|25|38.0|Non-synonymous|Unprocessed|APF-G1
1762137|IGL00781|9|44089165|R->Stop|||N/A|||MGI:1858178|Usp2|ubiquitin specific peptidase 2 [Source:MGI Symbol;Acc:MGI:1858178]|Heterozygous||C|T|23|34.0|Non-synonymous|Unprocessed|APF-G1
1762138|IGL00781|19|8773661|G->D||1.0|Probably damaging||deleterious|MGI:1914956|Tmem179b|transmembrane protein 179B [Source:MGI Symbol;Acc:MGI:1914956]|Heterozygous||C|T|17|37.0|Non-synonymous|Unprocessed|APF-G1
1762139|IGL00781|2|91146928|I->V|||Benign|0.1|tolerated|MGI:2444672|Madd|MAP-kinase activating death domain [Source:MGI Symbol;Acc:MGI:2444672]|Heterozygous||T|C|17|39.0|Non-synonymous|Unprocessed|APF-G1
1762140|IGL00781|9|31103779|S->P||1.0|Probably damaging||deleterious|MGI:1338881|St14|suppression of tumorigenicity 14 (colon carcinoma) [Source:MGI Symbol;Acc:MGI:1338881]|Heterozygous|Homozygous inactivation of this locus results in pleiotropic defects affecting the development of the epidermis, hair follicles, and immune system. Mutant mice become dehydrated due to impaired epidermal barrier function and die within days of birth.|A|G|16|37.0|Non-synonymous|Unprocessed|APF-G1
1762141|IGL00781|2|128893851|R->Q||1.0|Probably damaging|0.16|tolerated|MGI:1917620|Fbln7|fibulin 7 [Source:MGI Symbol;Acc:MGI:1917620]|Heterozygous||G|A|13|35.0|Non-synonymous|Unprocessed|APF-G1
1762142|IGL00781|2|181003479|V->F||0.93|Possibly damaging||deleterious|MGI:1920618|Col20a1|collagen, type XX, alpha 1 [Source:MGI Symbol;Acc:MGI:1920618]|Heterozygous||G|T|10|38.5|Non-synonymous|Unprocessed|APF-G1
1762145|IGL00781|5|45555192|Disrupted splicing||||||MGI:2442958|Fam184b|family with sequence similarity 184, member B [Source:MGI Symbol;Acc:MGI:2442958]|Heterozygous|Mice homozygous for a knock-out allele are viable and exhibit no overt phenotypic abnormalities.|A|T|63|39.0|Splice|Unprocessed|APF-G1
1762146|IGL00781|2|30083390|Disrupted splicing||||||MGI:2388285|Pkn3|protein kinase N3 [Source:MGI Symbol;Acc:MGI:2388285]|Heterozygous||C|A|31|36.0|Splice|Unprocessed|APF-G1
1763163|IGL00783|3|72946632|H->R|||Benign|0.41|tolerated|MGI:97528|Sis|sucrase isomaltase (alpha-glucosidase) [Source:MGI Symbol;Acc:MGI:1917233]|Heterozygous||T|C|108|40.0|Non-synonymous|Unprocessed|APF-G1
1763164|IGL00783|6|124872989|V->A||1.0|Probably damaging||deleterious|MGI:88335|Cd4|CD4 antigen [Source:MGI Symbol;Acc:MGI:88335]|Heterozygous|Mice homozygous for knock-out alleles exhibit abnormal immune system morphology and physiology.|A|G|49|38.0|Non-synonymous|Unprocessed|APF-G1
1763165|IGL00783|X|20377169|C->S||0.41|Benign|0.05|tolerated|MGI:1277953|Rp2h|retinitis pigmentosa 2 homolog (human) [Source:MGI Symbol;Acc:MGI:1277953]|Heterozygous||T|A|45|38.0|Non-synonymous|Unprocessed|APF-G1
1763166|IGL00783|5|23492358|I->V||0.98|Probably damaging|0.04|deleterious|MGI:1924825|Mll5|myeloid/lymphoid or mixed-lineage leukemia 5 [Source:MGI Symbol;Acc:MGI:1924825]|Heterozygous|Mice homozygous for a null allele exhibit neonatal and postnatal lethality, reduced fertility and growth, and abnormal lymphopoiesis.|A|G|42|38.0|Non-synonymous|Unprocessed|APF-G1
1763167|IGL00783|5|26104155|R->G||0.99|Probably damaging||deleterious|MGI:3036277|5031410i06rik|RIKEN cDNA 5031410I06 gene [Source:MGI Symbol;Acc:MGI:3036277]|Heterozygous||T|C|36|38.5|Non-synonymous|Unprocessed|APF-G1
1763168|IGL00783|7|28820642|F->L|||Benign|0.03|deleterious|MGI:104816|Hnrnpl|heterogeneous nuclear ribonucleoprotein L [Source:MGI Symbol;Acc:MGI:104816]|Heterozygous||T|C|36|36.0|Non-synonymous|Unprocessed|APF-G1
1763169|IGL00783|1|66608437|G->E|||Unknown|0.2|tolerated|MGI:2652882|Unc80|unc-80 homolog (C. elegans) [Source:MGI Symbol;Acc:MGI:2652882]|Heterozygous||G|A|33|37.0|Non-synonymous|Unprocessed|APF-G1
1763170|IGL00783|9|98992165|G->R||1.0|Probably damaging|0.15|tolerated|MGI:1344387|Faim|Fas apoptotic inhibitory molecule [Source:MGI Symbol;Acc:MGI:1344387]|Heterozygous|Mice homozygous for a null allele have thymocytes with an enhanced susceptibility to FAS-induced apoptosis, and B cells that more susceptible to activation induced cell death.|G|A|31|39.0|Non-synonymous|Unprocessed|APF-G1
1763171|IGL00783|17|80368230|I->L||0.01|Benign|0.93|tolerated|MGI:2685787|Arhgef33|Rho guanine nucleotide exchange factor (GEF) 33 [Source:MGI Symbol;Acc:MGI:2685787]|Heterozygous||A|T|30|38.5|Non-synonymous|Unprocessed|APF-G1
1763172|IGL00783|2|3314809|F->I||1.0|Probably damaging|0.01|deleterious|MGI:1202298|Nmt2|N-myristoyltransferase 2 [Source:MGI Symbol;Acc:MGI:1202298]|Heterozygous||T|A|29|38.0|Non-synonymous|Unprocessed|APF-G1
1763173|IGL00783|9|40922752|T->A|||Benign|0.13|tolerated|MGI:1918239|4931429i11rik|RIKEN cDNA 4931429I11 gene [Source:MGI Symbol;Acc:MGI:1918239]|Heterozygous||T|C|28|38.5|Non-synonymous|Unprocessed|APF-G1
1763174|IGL00783|6|115905902|H->Q|||Benign|0.56|tolerated|MGI:1932386|Ift122|intraflagellar transport 122 homolog (Chlamydomonas) [Source:MGI Symbol;Acc:MGI:1932386]|Heterozygous|Homozygotes for a null mutation display embryonic lethality during organogenesis with exencephaly, a ventralized caudal neural tube, preaxial polydactyly, abnormal cilia, and left-right patterning defects.|T|A|21|39.0|Non-synonymous|Unprocessed|APF-G1
1763175|IGL00783|2|66692564|E->A||1.0|Probably damaging||deleterious|MGI:102965|Scn7a|sodium channel, voltage-gated, type VII, alpha [Source:MGI Symbol;Acc:MGI:102965]|Heterozygous|Mice homozygous for disruptions in this gene have a modified dietary preference for NaCl but are phenotypically normal otherwise.|T|G|16|36.5|Non-synonymous|Unprocessed|APF-G1
1763176|IGL00783|11|106699798|D->G||0.99|Probably damaging||deleterious|MGI:97537|Pecam1|platelet/endothelial cell adhesion molecule 1 [Source:MGI Symbol;Acc:MGI:97537]|Heterozygous||T|C|15|38.0|Non-synonymous|Unprocessed|APF-G1
1763177|IGL00783|3|101431239|R->G||1.0|Probably damaging|0.04|deleterious|MGI:1926158|Igsf3|immunoglobulin superfamily, member 3 [Source:MGI Symbol;Acc:MGI:1926158]|Heterozygous||A|G|15|39.0|Non-synonymous|Unprocessed|APF-G1
1763178|IGL00783|11|5872412|E->G|||Benign|0.4|tolerated|MGI:1097163|Pold2|polymerase (DNA directed), delta 2, regulatory subunit [Source:MGI Symbol;Acc:MGI:1097163]|Heterozygous||T|C|13|33.0|Non-synonymous|Unprocessed|APF-G1
1763179|IGL00783|10|121416080|H->R|||Benign|0.39|tolerated|MGI:2179722|Rassf3|Ras association (RalGDS/AF-6) domain family member 3 [Source:MGI Symbol;Acc:MGI:2179722]|Heterozygous||T|C|12|37.0|Non-synonymous|Unprocessed|APF-G1
1763180|IGL00783|8|113652862|D->G|||Benign|0.02|deleterious|MGI:1922247|Syce1l|synaptonemal complex central element protein 1 like [Source:MGI Symbol;Acc:MGI:1922247]|Heterozygous||A|G|12|34.5|Non-synonymous|Unprocessed|APF-G1
1763181|IGL00783|11|115348510|Y->N||1.0|Probably damaging|0.08|tolerated|MGI:2445087|C630004h02rik|RIKEN cDNA C630004H02 gene [Source:MGI Symbol;Acc:MGI:2445087]|Heterozygous||A|T|11|35.0|Non-synonymous|Unprocessed|APF-G1
1763182|IGL00783|5|120738363|F->S||1.0|Probably damaging||deleterious|MGI:2180852|Oas2|2'-5' oligoadenylate synthetase 2 [Source:MGI Symbol;Acc:MGI:2180852]|Heterozygous||A|G|11|35.0|Non-synonymous|Unprocessed|APF-G1
1763188|IGL00783|1|80572449|Disrupted splicing||||||MGI:2146320|Dock10|dedicator of cytokinesis 10 [Source:MGI Symbol;Acc:MGI:2146320]|Heterozygous||A|G|25|38.0|Splice|Unprocessed|APF-G1
1763189|IGL00783|11|99070395|Disrupted splicing||||||MGI:2144377|Tns4|tensin 4 [Source:MGI Symbol;Acc:MGI:2144377]|Heterozygous||A|G|16|37.5|Splice|Unprocessed|APF-G1
1763190|IGL00783|8|94309023|Disrupted splicing||||||MGI:1919055|Nup93|nucleoporin 93 [Source:MGI Symbol;Acc:MGI:1919055]|Heterozygous||G|A|12|37.5|Splice|Unprocessed|APF-G1
1763663|IGL00784|6|124872989|V->A||1.0|Probably damaging||deleterious|MGI:88335|Cd4|CD4 antigen [Source:MGI Symbol;Acc:MGI:88335]|Heterozygous|Mice homozygous for knock-out alleles exhibit abnormal immune system morphology and physiology.|A|G|51|34.0|Non-synonymous|Unprocessed|APF-G1
1763664|IGL00784|17|80368230|I->L||0.01|Benign|0.93|tolerated|MGI:2685787|Arhgef33|Rho guanine nucleotide exchange factor (GEF) 33 [Source:MGI Symbol;Acc:MGI:2685787]|Heterozygous||A|T|39|39.0|Non-synonymous|Unprocessed|APF-G1
1763665|IGL00784|9|40922752|T->A|||Benign|0.13|tolerated|MGI:1918239|4931429i11rik|RIKEN cDNA 4931429I11 gene [Source:MGI Symbol;Acc:MGI:1918239]|Heterozygous||T|C|39|39.0|Non-synonymous|Unprocessed|APF-G1
1763666|IGL00784|7|28820642|F->L|||Benign|0.03|deleterious|MGI:104816|Hnrnpl|heterogeneous nuclear ribonucleoprotein L [Source:MGI Symbol;Acc:MGI:104816]|Heterozygous||T|C|35|37.0|Non-synonymous|Unprocessed|APF-G1
1763667|IGL00784|9|98992165|G->R||1.0|Probably damaging|0.15|tolerated|MGI:1344387|Faim|Fas apoptotic inhibitory molecule [Source:MGI Symbol;Acc:MGI:1344387]|Heterozygous|Mice homozygous for a null allele have thymocytes with an enhanced susceptibility to FAS-induced apoptosis, and B cells that more susceptible to activation induced cell death.|G|A|33|37.0|Non-synonymous|Unprocessed|APF-G1
1763668|IGL00784|1|66608437|G->E|||Unknown|0.2|tolerated|MGI:2652882|Unc80|unc-80 homolog (C. elegans) [Source:MGI Symbol;Acc:MGI:2652882]|Heterozygous||G|A|30|37.5|Non-synonymous|Unprocessed|APF-G1
1763669|IGL00784|15|35846900|D->Y||1.0|Probably damaging||deleterious|MGI:1916380|Vps13b|vacuolar protein sorting 13B (yeast) [Source:MGI Symbol;Acc:MGI:1916380]|Heterozygous||G|T|28|38.5|Non-synonymous|Unprocessed|APF-G1
1763670|IGL00784|2|3314809|F->I||1.0|Probably damaging|0.01|deleterious|MGI:1202298|Nmt2|N-myristoyltransferase 2 [Source:MGI Symbol;Acc:MGI:1202298]|Heterozygous||T|A|27|39.0|Non-synonymous|Unprocessed|APF-G1
1763671|IGL00784|8|113652862|D->G|||Benign|0.02|deleterious|MGI:1922247|Syce1l|synaptonemal complex central element protein 1 like [Source:MGI Symbol;Acc:MGI:1922247]|Heterozygous||A|G|26|38.0|Non-synonymous|Unprocessed|APF-G1
1763672|IGL00784|6|115905902|H->Q|||Benign|0.56|tolerated|MGI:1932386|Ift122|intraflagellar transport 122 homolog (Chlamydomonas) [Source:MGI Symbol;Acc:MGI:1932386]|Heterozygous|Homozygotes for a null mutation display embryonic lethality during organogenesis with exencephaly, a ventralized caudal neural tube, preaxial polydactyly, abnormal cilia, and left-right patterning defects.|T|A|20|36.0|Non-synonymous|Unprocessed|APF-G1
1763673|IGL00784|11|5872412|E->G|||Benign|0.4|tolerated|MGI:1097163|Pold2|polymerase (DNA directed), delta 2, regulatory subunit [Source:MGI Symbol;Acc:MGI:1097163]|Heterozygous||T|C|19|38.0|Non-synonymous|Unprocessed|APF-G1
1763674|IGL00784|2|66692564|E->A||1.0|Probably damaging||deleterious|MGI:102965|Scn7a|sodium channel, voltage-gated, type VII, alpha [Source:MGI Symbol;Acc:MGI:102965]|Heterozygous|Mice homozygous for disruptions in this gene have a modified dietary preference for NaCl but are phenotypically normal otherwise.|T|G|16|37.0|Non-synonymous|Unprocessed|APF-G1
1763675|IGL00784|5|120738363|F->S||1.0|Probably damaging||deleterious|MGI:2180852|Oas2|2'-5' oligoadenylate synthetase 2 [Source:MGI Symbol;Acc:MGI:2180852]|Heterozygous||A|G|13|39.0|Non-synonymous|Unprocessed|APF-G1
1763676|IGL00784|7|35405707|V->E||0.7|Possibly damaging|0.13|tolerated|MGI:1919390|Ccdc123|coiled-coil domain containing 123 [Source:MGI Symbol;Acc:MGI:1919390]|Heterozygous||T|A|13|38.0|Non-synonymous|Unprocessed|APF-G1
1763677|IGL00784|15|89370040|D->G||1.0|Probably damaging|0.13|tolerated|MGI:1289164|Ncaph2|non-SMC condensin II complex, subunit H2 [Source:MGI Symbol;Acc:MGI:1289164]|Heterozygous|Mice homozygous for an ENU-induced single point mutation display a specific defect in T cell development but are otherwise viable, fertile and overtly healthy with no apparent defects in B cell development.|A|G|12|36.5|Non-synonymous|Unprocessed|APF-G1
1763678|IGL00784|1|58988529|S->P||0.51|Possibly damaging|0.06|tolerated|MGI:2144047|Stradb|STE20-related kinase adaptor beta [Source:MGI Symbol;Acc:MGI:2144047]|Heterozygous||T|C|11|40.0|Non-synonymous|Unprocessed|APF-G1
1763681|IGL00784|9|110629763|Disrupted splicing||||||MGI:2448554|Nbeal2|neurobeachin-like 2 [Source:MGI Symbol;Acc:MGI:2448554]|Heterozygous||T|C|28|37.0|Splice|Unprocessed|APF-G1
1763682|IGL00784|1|80572449|Disrupted splicing||||||MGI:2146320|Dock10|dedicator of cytokinesis 10 [Source:MGI Symbol;Acc:MGI:2146320]|Heterozygous||A|G|24|38.5|Splice|Unprocessed|APF-G1
1763683|IGL00784|17|13849263|Disrupted splicing||||||MGI:1314653|Mllt4|myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 [Source:MGI Symbol;Acc:MGI:1314653]|Heterozygous|Homozygous null mice display embryonic lethality, abnormal ectoderm development including disrupted cell junctions, and absence of the somites, notochord, allantois, and neural folds.|A|G|22|39.5|Splice|Unprocessed|APF-G1
1764172|IGL00785|6|38598786|S->P|||Unknown|0.33|tolerated|MGI:2183260|Luc7l2|LUC7-like 2 (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:2183260]|Heterozygous||T|C|244|39.0|Non-synonymous|Unprocessed|APF-G1
1764173|IGL00785|19|37404298|L->P||0.99|Probably damaging||deleterious|MGI:1098231|Kif11|kinesin family member 11 [Source:MGI Symbol;Acc:MGI:1098231]|Heterozygous|Deletion of Kif11 results in early embryonic lethality of homozygotes, with developmental growth arrest at E3.5.|T|C|73|39.0|Non-synonymous|Unprocessed|APF-G1
1764174|IGL00785|19|37404297|L->I||0.29|Benign|0.11|tolerated|MGI:1098231|Kif11|kinesin family member 11 [Source:MGI Symbol;Acc:MGI:1098231]|Heterozygous|Deletion of Kif11 results in early embryonic lethality of homozygotes, with developmental growth arrest at E3.5.|C|A|72|39.0|Non-synonymous|Unprocessed|APF-G1
1764175|IGL00785|5|53065608|I->F||0.01|Benign|0.04|deleterious|MGI:1342284|Slc34a2|solute carrier family 34 (sodium phosphate), member 2 [Source:MGI Symbol;Acc:MGI:1342284]|Heterozygous|Homozygous null mice display embryonic lethality, embryonic growth arrest, failure of embryo turning and somitogenesis, impaired placental development and impaired yolk sac vascular remodeling.|A|T|62|39.0|Non-synonymous|Unprocessed|APF-G1
1764176|IGL00785|10|111273044|T->A||0.97|Probably damaging|0.1|tolerated|MGI:2443807|Osbpl8|oxysterol binding protein-like 8 [Source:MGI Symbol;Acc:MGI:2443807]|Heterozygous||A|G|59|38.0|Non-synonymous|Unprocessed|APF-G1
1764177|IGL00785|15|6776950|Q->P||0.97|Probably damaging|0.01|deleterious|MGI:1926007|Rictor|RPTOR independent companion of MTOR, complex 2 [Source:MGI Symbol;Acc:MGI:1926007]|Heterozygous|Mice homozygous for a null allele exhibit embryonic lethality during organogenesis associated with abnormal placental morphology.|A|C|57|39.0|Non-synonymous|Unprocessed|APF-G1
1764178|IGL00785|2|94045414|S->P||1.0|Probably damaging||deleterious|MGI:1926967|Hsd17b12|hydroxysteroid (17-beta) dehydrogenase 12 [Source:MGI Symbol;Acc:MGI:1926967]|Heterozygous|Mice homozygous for a gene trap allele exhibit die around E8.5 with abnormal embryonic and extraembryonic tissue development. ES cells heterozygous for this allele exhibit reduced arachidonic acid levels.|A|G|57|37.0|Non-synonymous|Unprocessed|APF-G1
1764179|IGL00785|7|107737887|T->A|||Benign|0.84|tolerated|MGI:894649|Ppfibp2|PTPRF interacting protein, binding protein 2 (liprin beta 2) [Source:MGI Symbol;Acc:MGI:894649]|Heterozygous||A|G|57|37.0|Non-synonymous|Unprocessed|APF-G1
1764180|IGL00785|17|46204692|V->A||0.78|Possibly damaging|0.59|tolerated|MGI:1913789|Xpo5|exportin 5 [Source:MGI Symbol;Acc:MGI:1913789]|Heterozygous||T|C|49|39.0|Non-synonymous|Unprocessed|APF-G1
1764181|IGL00785|15|85882831|D->E|||Benign|1.0|tolerated|MGI:1919276|Trmu|tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase [Source:MGI Symbol;Acc:MGI:1919276]|Heterozygous||T|A|45|39.0|Non-synonymous|Unprocessed|APF-G1
1764182|IGL00785|6|83929164|W->R||0.92|Possibly damaging||deleterious|MGI:1203484|Zfml|zinc finger, matrin-like [Source:MGI Symbol;Acc:MGI:1203484]|Heterozygous||T|C|42|37.0|Non-synonymous|Unprocessed|APF-G1
1764183|IGL00785|19|3366389|N->K||1.0|Probably damaging||deleterious|MGI:1098296|Cpt1a|carnitine palmitoyltransferase 1a, liver [Source:MGI Symbol;Acc:MGI:1098296]|Heterozygous|Homozygous null mice display embryonic lethality. Heterozygous null mice display decreased serum glucose and increased serum free fatty acid levels after fasting.|T|A|41|37.0|Non-synonymous|Unprocessed|APF-G1
1764184|IGL00785|13|48889133|S->P||0.06|Benign|0.36|tolerated|MGI:2446163|Fam120a|family with sequence similarity 120, member A [Source:MGI Symbol;Acc:MGI:2446163]|Heterozygous||A|G|36|34.0|Non-synonymous|Unprocessed|APF-G1
1764185|IGL00785|17|46944865|T->I||0.04|Benign|0.14|tolerated|MGI:1861099|Ubr2|ubiquitin protein ligase E3 component n-recognin 2 [Source:MGI Symbol;Acc:MGI:1861099]|Heterozygous|On a mixed genetic background, female homozygotes for a targeted null mutation exhibit embryonic lethality, while males are viable, but sterile due to postnatal testicular degeneration. On an inbred background, both genders die in utero.|G|A|32|37.5|Non-synonymous|Unprocessed|APF-G1
1764186|IGL00785|2|79657268|E->G||0.82|Possibly damaging|0.04|deleterious|MGI:1917849|Ssfa2|sperm specific antigen 2 [Source:MGI Symbol;Acc:MGI:1917849]|Heterozygous|Mice homozygous for a null mutation display decreased body weight, resistance to diet induced obesity, increased food intake, decreased adipose tissue mass, elevated metabolic rate, abnormal glucose homeostasis, and abnormal hormone levels.|A|G|32|37.0|Non-synonymous|Unprocessed|APF-G1
1764187|IGL00785|9|98992165|G->R||1.0|Probably damaging|0.15|tolerated|MGI:1344387|Faim|Fas apoptotic inhibitory molecule [Source:MGI Symbol;Acc:MGI:1344387]|Heterozygous|Mice homozygous for a null allele have thymocytes with an enhanced susceptibility to FAS-induced apoptosis, and B cells that more susceptible to activation induced cell death.|G|A|30|37.0|Non-synonymous|Unprocessed|APF-G1
1764188|IGL00785|2|120441598|Y->S||0.99|Probably damaging||deleterious|MGI:1923301|Ganc|glucosidase, alpha; neutral C [Source:MGI Symbol;Acc:MGI:1923301]|Heterozygous||A|C|28|38.5|Non-synonymous|Unprocessed|APF-G1
1764189|IGL00785|7|98054348|K->E|||||deleterious|MGI:104510|Myo7a|myosin VIIA [Source:MGI Symbol;Acc:MGI:104510]|Heterozygous|Homozygotes for spontaneous and chemically induced mutations exhibit deafness, hyperactivity, head-shaking, and circling, with degeneration of the organ of Corti, spiral ganglion, stria vascularis in the cochlea, and vestibular ganglion in the labyrinth.|T|C|22|37.0|Non-synonymous|Unprocessed|APF-G1
1764190|IGL00785|10|63566833|F->V||1.0|Probably damaging||deleterious|MGI:2661445|Ctnna3|catenin (cadherin associated protein), alpha 3 [Source:MGI Symbol;Acc:MGI:2661445]|Heterozygous||T|G|21|38.0|Non-synonymous|Unprocessed|APF-G1
1764191|IGL00785|2|37792064|C->Y||1.0|Probably damaging||deleterious|MGI:2679260|Crb2|crumbs homolog 2 (Drosophila) [Source:MGI Symbol;Acc:MGI:2679260]|Heterozygous||G|A|17|37.0|Non-synonymous|Unprocessed|APF-G1
1764192|IGL00785|3|55955393|S->P|||Benign|0.4|tolerated|MGI:1347075|Nbea|neurobeachin [Source:MGI Symbol;Acc:MGI:1347075]|Heterozygous|Mice homozygous for a gene trapped allele or transgene insertion die shortly after birth, are cyanotic, and exhibit no response to tactile stimuli, no spontaneous movement, and impaired CNS synaptic transmission.|A|G|17|37.0|Non-synonymous|Unprocessed|APF-G1
1764193|IGL00785|2|112836103|H->Q||0.04|Benign|||MGI:99684|Ryr3|ryanodine receptor 3 [Source:MGI Symbol;Acc:MGI:99684]|Heterozygous|Homozygotes for targeted null mutations exhibit impaired muscle contraction at an early age, changes in hippocampal synaptic plasticity, increased locomotor activity with a tendency to circle, and impaired relearning of a spatial task.|A|T|15|38.0|Non-synonymous|Unprocessed|APF-G1
1764194|IGL00785|5|114628625|V->A||1.0|Probably damaging||deleterious|MGI:1926945|Trpv4|transient receptor potential cation channel, subfamily V, member 4 [Source:MGI Symbol;Acc:MGI:1926945]|Heterozygous|Null mutations of this locus have been associated with reduced responsiveness to pressure sensations and abnormal osmotic regulation.|A|G|10|38.0|Non-synonymous|Unprocessed|APF-G1
1764197|IGL00785|3|104873579|Disrupted splicing||||||MGI:2386964|St7l|suppression of tumorigenicity 7-like [Source:MGI Symbol;Acc:MGI:2386964]|Heterozygous||A|G|42|38.0|Splice|Unprocessed|APF-G1
1764198|IGL00785|1|93274169|Disrupted splicing||||||MGI:3045960|Sned1|sushi, nidogen and EGF-like domains 1 [Source:MGI Symbol;Acc:MGI:3045960]|Heterozygous||C|A|25|36.0|Splice|Unprocessed|APF-G1
1764711|IGL00786|14|56672544|V->A||0.02|Benign|0.66|tolerated|MGI:1922589|Mphosph8|M-phase phosphoprotein 8 [Source:MGI Symbol;Acc:MGI:1922589]|Heterozygous||T|C|206|38.0|Non-synonymous|Unprocessed|APF-G1
1764712|IGL00786|11|102193105|M->V|||Benign|0.21|tolerated|MGI:1915651|G6pc3|glucose 6 phosphatase, catalytic, 3 [Source:MGI Symbol;Acc:MGI:1915651]|Heterozygous|Homozygous mutation of this gene results in females, but not males, that are growth retarded and weight less and exhibit elevated plasma glucagon levels but lowered plasma cholesterols after fasting.|A|G|119|35.0|Non-synonymous|Unprocessed|APF-G1
1764713|IGL00786|11|22100460|S->P||||0.02|deleterious|MGI:2667252|Ehbp1|EH domain binding protein 1 [Source:MGI Symbol;Acc:MGI:2667252]|Heterozygous||A|G|101|38.0|Non-synonymous|Unprocessed|APF-G1
1764714|IGL00786|17|85096491|V->A||0.97|Probably damaging|1.0|tolerated|MGI:1920832|1700106n22rik|RIKEN cDNA 1700106N22 gene [Source:MGI Symbol;Acc:MGI:1920832]|Heterozygous||T|C|101|38.0|Non-synonymous|Unprocessed|APF-G1
1764715|IGL00786|2|35375839|N->S|||Benign|0.31|tolerated|MGI:1922104|4930402f06rik|RIKEN cDNA 4930402F06 gene [Source:MGI Symbol;Acc:MGI:1922104]|Heterozygous||T|C|96|40.0|Non-synonymous|Unprocessed|APF-G1
1764716|IGL00786|4|155820880|R->W||1.0|Probably damaging||deleterious|MGI:1927119|Ccnl2|cyclin L2 [Source:MGI Symbol;Acc:MGI:1927119]|Heterozygous||C|T|87|40.0|Non-synonymous|Unprocessed|APF-G1
1764717|IGL00786|19|58760497|N->S|||Benign|0.17|tolerated|MGI:1336202|Pnliprp2|pancreatic lipase-related protein 2 [Source:MGI Symbol;Acc:MGI:1336202]|Heterozygous|Mice homozygous for disruptions in this gene display deficient lipid absorbtion before weaning which results in growth retardation.|A|G|54|37.0|Non-synonymous|Unprocessed|APF-G1
1764718|IGL00786|5|4070522|A->E||1.0|Probably damaging||deleterious|MGI:2178217|Akap9|A kinase (PRKA) anchor protein (yotiao) 9 [Source:MGI Symbol;Acc:MGI:2178217]|Heterozygous||C|A|52|38.0|Non-synonymous|Unprocessed|APF-G1
1764719|IGL00786|8|121104468|R->Q||1.0|Probably damaging|0.09|tolerated|MGI:2679252|Mthfsd|methenyltetrahydrofolate synthetase domain containing [Source:MGI Symbol;Acc:MGI:2679252]|Heterozygous||C|T|45|36.0|Non-synonymous|Unprocessed|APF-G1
1764720|IGL00786|9|21345935|V->E||0.99|Probably damaging|0.01|deleterious|MGI:1915932|Slc44a2|solute carrier family 44, member 2 [Source:MGI Symbol;Acc:MGI:1915932]|Heterozygous||T|A|44|38.0|Non-synonymous|Unprocessed|APF-G1
1764721|IGL00786|2|143079926|V->I||1.0|Probably damaging|0.04|deleterious|MGI:1888678|Otor|otoraplin [Source:MGI Symbol;Acc:MGI:1888678]|Heterozygous||G|A|43|40.0|Non-synonymous|Unprocessed|APF-G1
1764722|IGL00786|11|95031935|T->S|||Benign|1.0|tolerated|MGI:1343087|Pdk2|pyruvate dehydrogenase kinase, isoenzyme 2 [Source:MGI Symbol;Acc:MGI:1343087]|Heterozygous|Mice homozygous for a knock-out allele exhibit decreased muscle contractile force.|T|A|36|35.0|Non-synonymous|Unprocessed|APF-G1
1764723|IGL00786|6|13602675|I->V|||Benign|0.51|tolerated|MGI:1921794|Tmem168|transmembrane protein 168 [Source:MGI Symbol;Acc:MGI:1921794]|Heterozygous||T|C|30|39.0|Non-synonymous|Unprocessed|APF-G1
1764724|IGL00786|9|98992165|G->R||1.0|Probably damaging|0.15|tolerated|MGI:1344387|Faim|Fas apoptotic inhibitory molecule [Source:MGI Symbol;Acc:MGI:1344387]|Heterozygous|Mice homozygous for a null allele have thymocytes with an enhanced susceptibility to FAS-induced apoptosis, and B cells that more susceptible to activation induced cell death.|G|A|29|39.0|Non-synonymous|Unprocessed|APF-G1
1764725|IGL00786|17|27879292|I->N||0.99|Probably damaging|0.07|tolerated|MGI:3041238|Uhrf1bp1|UHRF1 (ICBP90) binding protein 1 [Source:MGI Symbol;Acc:MGI:3041238]|Heterozygous||T|A|27|37.0|Non-synonymous|Unprocessed|APF-G1
1764726|IGL00786|6|103675145|V->F||0.91|Possibly damaging||deleterious|MGI:1098266|Chl1|cell adhesion molecule with homology to L1CAM [Source:MGI Symbol;Acc:MGI:1098266]|Heterozygous|Homozygous mutation of this gene results in enlargement of the lateral ventricles and altered hippocampal mossy fiber organization. Mutant animals exhibit altered exploratory behavior.|G|T|27|38.0|Non-synonymous|Unprocessed|APF-G1
1764727|IGL00786|7|19202582|Y->C||1.0|Probably damaging||deleterious|MGI:1919455|Eml2|echinoderm microtubule associated protein like 2 [Source:MGI Symbol;Acc:MGI:1919455]|Heterozygous||A|G|27|37.0|Non-synonymous|Unprocessed|APF-G1
1764728|IGL00786|1|65166243|S->P||1.0|Probably damaging||deleterious|MGI:96413|Idh1|isocitrate dehydrogenase 1 (NADP+), soluble [Source:MGI Symbol;Acc:MGI:96413]|Heterozygous|Electrophoretic variation has been shown in tissues of liver, kidney, spleen and muscle. Strains C57BL/6, C3H/He carry the a allele; DBA/2 carries the b allele; M.m. castaneus and M.m. molossinus carry the c allele; the d allele is found at low frequency in M. m. molossinus in Japan.|A|G|26|37.5|Non-synonymous|Unprocessed|APF-G1
1764729|IGL00786|12|112657671|G->V||1.0|Probably damaging||deleterious|MGI:87986|Akt1|thymoma viral proto-oncogene 1 [Source:MGI Symbol;Acc:MGI:87986]|Heterozygous|Mutant homozygotes are smaller than sibs due to retarded prenatal and postnatal growth and exhibit increased apopotosis and decreased lifespan with genotoxic stress. Mice are fertile, but males have attenuated spermatogenesis and abnormal testes.|C|A|26|36.0|Non-synonymous|Unprocessed|APF-G1
1764730|IGL00786|4|117676396|R->Q||1.0|Probably damaging|0.01|deleterious|MGI:1913483|Dmap1|DNA methyltransferase 1-associated protein 1 [Source:MGI Symbol;Acc:MGI:1913483]|Heterozygous|Mice homozygous for a knock-out allele die prior to implantation with no 8-cell embryos detected.|C|T|25|35.0|Non-synonymous|Unprocessed|APF-G1
1764731|IGL00786|9|90064238|V->A||1.0|Probably damaging||deleterious|MGI:107285|Ctsh|cathepsin H [Source:MGI Symbol;Acc:MGI:107285]|Heterozygous|Mice homozygous for a reporter allele exhibit no abnormal phenotype.|T|C|25|38.0|Non-synonymous|Unprocessed|APF-G1
1764732|IGL00786|16|17211688|T->M||0.01|Benign||deleterious|MGI:2685449|Rimbp3|RIMS binding protein 3 [Source:MGI Symbol;Acc:MGI:2685449]|Heterozygous||C|T|22|37.5|Non-synonymous|Unprocessed|APF-G1
1764733|IGL00786|9|45949803|S->P||0.01|Benign|0.23|tolerated|MGI:2446134|Sidt2|SID1 transmembrane family, member 2 [Source:MGI Symbol;Acc:MGI:2446134]|Heterozygous||A|G|22|38.0|Non-synonymous|Unprocessed|APF-G1
1764734|IGL00786|6|25669318|V->A||0.84|Possibly damaging|0.07|tolerated|MGI:1313297|Gpr37|G protein-coupled receptor 37 [Source:MGI Symbol;Acc:MGI:1313297]|Heterozygous|Mice homozygous for disruptions in this gene exhibit reduced striatal dopamine content, enhanced amphetamine sensitivity, reduced motor activity and coordination and increased percentage of body fat in females.|A|G|21|31.0|Non-synonymous|Unprocessed|APF-G1
1764735|IGL00786|2|154167252|C->Y||1.0|Probably damaging||deleterious|MGI:1914385|2310021h06rik|RIKEN cDNA 2310021H06 gene [Source:MGI Symbol;Acc:MGI:1914385]|Heterozygous||G|A|20|36.5|Non-synonymous|Unprocessed|APF-G1
1764736|IGL00786|2|148872877|C->Stop|||N/A|||MGI:102519|Cst3|cystatin C [Source:MGI Symbol;Acc:MGI:102519]|Heterozygous|Mice homozygous for a null allele exhibit increased metastatic potential and decreased susceptibility to ischemic brain injury.|A|T|19|37.0|Non-synonymous|Unprocessed|APF-G1
1764737|IGL00786|19|8926785|E->G||0.01|Benign|0.24|tolerated|MGI:1919977|B3gat3|beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I) [Source:MGI Symbol;Acc:MGI:1919977]|Heterozygous||A|G|15|32.0|Non-synonymous|Unprocessed|APF-G1
1764738|IGL00786|17|78824634|H->N||0.98|Probably damaging|0.19|tolerated|MGI:2444098|Heatr5b|HEAT repeat containing 5B [Source:MGI Symbol;Acc:MGI:2444098]|Heterozygous||G|T|14|37.0|Non-synonymous|Unprocessed|APF-G1
1764741|IGL00786|5|92303773|Disrupted splicing||||||MGI:2140779|Sdad1|SDA1 domain containing 1 [Source:MGI Symbol;Acc:MGI:2140779]|Heterozygous||A|T|70|36.0|Splice|Unprocessed|APF-G1
1764742|IGL00786|2|13578510|Disrupted splicing||||||MGI:98932|Vim|vimentin [Source:MGI Symbol;Acc:MGI:98932]|Heterozygous|Homozygous null mutants exhibit impaired performance in motor coordination tests; cerebellum shows underdeveloped/abnormal Bergman glia and stunted, poorly branched Purkinje cells. Mutants are unable to survive experimental 75% reduction of kidney mass.|T|C|23|37.0|Splice|Unprocessed|APF-G1
1765219|IGL00787|8|104451807|S->T||0.07|Benign|0.48|tolerated|MGI:2443187|Ccdc79|coiled-coil domain containing 79 [Source:MGI Symbol;Acc:MGI:2443187]|Heterozygous||A|T|250|39.0|Non-synonymous|Unprocessed|APF-G1
1765220|IGL00787|5|81693554|N->K||1.0|Probably damaging|0.01|deleterious|MGI:2441950|Lphn3|latrophilin 3 [Source:MGI Symbol;Acc:MGI:2441950]|Heterozygous||T|G|82|39.0|Non-synonymous|Unprocessed|APF-G1
1765221|IGL00787|5|87242429|Y->F||0.5|Possibly damaging|0.17|tolerated|MGI:2148239|Ugt2b37|UDP glucuronosyltransferase 2 family, polypeptide B37 [Source:MGI Symbol;Acc:MGI:2148239]|Heterozygous||T|A|74|39.0|Non-synonymous|Unprocessed|APF-G1
1765222|IGL00787|6|125133546|S->L||1.0|Probably damaging||deleterious|MGI:107891|Nop2|NOP2 nucleolar protein homolog (yeast) [Source:MGI Symbol;Acc:MGI:107891]|Heterozygous||C|T|71|38.0|Non-synonymous|Unprocessed|APF-G1
1765223|IGL00787|11|41912522|R->G||0.01|Benign|0.42|tolerated|MGI:95623|Gabrg2|gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 [Source:MGI Symbol;Acc:MGI:95623]|Heterozygous|Homozygotes for a targeted null mutation exhibit retarded postnatal growth, impaired sensorimotor function, and greatly reduced lifespan. Heterozygotes show enhanced anxiety-related behaviors.|T|C|49|37.0|Non-synonymous|Unprocessed|APF-G1
1765224|IGL00787|11|30892290|F->L||0.97|Probably damaging|0.35|tolerated|MGI:2441843|Gpr75|G protein-coupled receptor 75 [Source:MGI Symbol;Acc:MGI:2441843]|Heterozygous||T|A|36|37.0|Non-synonymous|Unprocessed|APF-G1
1765225|IGL00787|3|98162170|S->T||0.01|Benign|0.66|tolerated|MGI:1918328|Adam30|a disintegrin and metallopeptidase domain 30 [Source:MGI Symbol;Acc:MGI:1918328]|Heterozygous||T|A|34|37.5|Non-synonymous|Unprocessed|APF-G1
1765226|IGL00787|14|31300063|V->E||0.64|Possibly damaging||deleterious|MGI:107721|Dnahc1|dynein, axonemal, heavy chain 1 [Source:MGI Symbol;Acc:MGI:107721]|Heterozygous|Homozygous mutants are male sterile, and show impaired ciliary and flagellar motility that is also observed in the tracheal cilia.|A|T|33|38.0|Non-synonymous|Unprocessed|APF-G1
1765227|IGL00787|5|73421489|F->I||0.02|Benign|0.39|tolerated|MGI:2444131|Cwh43|cell wall biogenesis 43 C-terminal homolog (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:2444131]|Heterozygous||T|A|31|38.0|Non-synonymous|Unprocessed|APF-G1
1765228|IGL00787|15|39143632|Y->Stop|||N/A|||MGI:2684929|Dcaf13|DDB1 and CUL4 associated factor 13 [Source:MGI Symbol;Acc:MGI:2684929]|Heterozygous||T|A|30|39.0|Non-synonymous|Unprocessed|APF-G1
1765229|IGL00787|8|93120366|S->T||1.0|Probably damaging|0.01|deleterious|MGI:95420|Ces1c|carboxylesterase 1C [Source:MGI Symbol;Acc:MGI:95420]|Heterozygous|Mice homozygous for a knock-out allele exhibit protection against nerve agents such as chlorpyrifos and chlorpyrifos oxon but increased sensitivity to soman coumarin.|A|T|30|38.0|Non-synonymous|Unprocessed|APF-G1
1765230|IGL00787|10|84676990|T->A|||Benign|0.78|tolerated|MGI:1917678|Polr3b|polymerase (RNA) III (DNA directed) polypeptide B [Source:MGI Symbol;Acc:MGI:1917678]|Heterozygous||A|G|22|37.0|Non-synonymous|Unprocessed|APF-G1
1765231|IGL00787|4|41397583|T->I||0.97|Probably damaging|0.01|deleterious|MGI:1918345|Kif24|kinesin family member 24 [Source:MGI Symbol;Acc:MGI:1918345]|Heterozygous||G|A|20|37.0|Non-synonymous|Unprocessed|APF-G1
1765232|IGL00787|4|41122198|V->I|||Benign|0.27|tolerated|MGI:2140151|Nol6|nucleolar protein family 6 (RNA-associated) [Source:MGI Symbol;Acc:MGI:2140151]|Heterozygous||C|T|11|38.0|Non-synonymous|Unprocessed|APF-G1
1765233|IGL00787|19|5111662|E->A||0.16|Benign|0.01|deleterious|MGI:107953|Klc2|kinesin light chain 2 [Source:MGI Symbol;Acc:MGI:107953]|Heterozygous||T|G|10|34.0|Non-synonymous|Unprocessed|APF-G1
1765241|IGL00787|18|6226973|Disrupted splicing||||||MGI:1098268|Kif5b|kinesin family member 5B [Source:MGI Symbol;Acc:MGI:1098268]|Heterozygous|Mice homozygous for disruptions in this gene die as embryos during organogenesis, exhibit growth retardation and fail to turn during gastrulation.|A|T|228|40.0|Splice|Unprocessed|APF-G1
1765242|IGL00787|14|78618514|Disrupted splicing||||||MGI:2444188|Dgkh|diacylglycerol kinase, eta [Source:MGI Symbol;Acc:MGI:2444188]|Heterozygous||A|C|67|39.0|Splice|Unprocessed|APF-G1
1765243|IGL00787|18|80458692|Disrupted splicing||||||MGI:1926953|Ctdp1|CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 [Source:MGI Symbol;Acc:MGI:1926953]|Heterozygous||C|A|34|38.0|Splice|Unprocessed|APF-G1
1765707|IGL00788|1|163024658|S->T|||Benign|0.62|tolerated|MGI:1925508|4921528o07rik|RIKEN cDNA 4921528O07 gene [Source:MGI Symbol;Acc:MGI:1925508]|Heterozygous||A|T|186|37.0|Non-synonymous|Unprocessed|APF-G1
1765708|IGL00788|3|86327685|M->L||0.74|Possibly damaging|0.58|tolerated|MGI:1933162|Lrba|LPS-responsive beige-like anchor [Source:MGI Symbol;Acc:MGI:1933162]|Heterozygous||A|T|86|39.0|Non-synonymous|Unprocessed|APF-G1
1765709|IGL00788|14|61605670|F->L|||Benign|0.82|tolerated|MGI:1913847|Trim13|tripartite motif-containing 13 [Source:MGI Symbol;Acc:MGI:1913847]|Heterozygous||T|C|79|37.0|Non-synonymous|Unprocessed|APF-G1
1765710|IGL00788|18|15453030|Y->H||0.02|Benign|0.25|tolerated|MGI:1918617|Chst9|carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9 [Source:MGI Symbol;Acc:MGI:1918617]|Heterozygous||A|G|65|39.0|Non-synonymous|Unprocessed|APF-G1
1765711|IGL00788|12|51748788|S->N||0.05|Benign|0.38|tolerated|MGI:2384768|Hectd1|HECT domain containing 1 [Source:MGI Symbol;Acc:MGI:2384768]|Heterozygous|Mice homozygous for a null mutation display perinatal lethality, exencephaly, impaired neural fold elevation, abnormal head mesenchyme morhology, and defects in eye and cranial vault morphology.|C|T|59|38.0|Non-synonymous|Unprocessed|APF-G1
1765712|IGL00788|1|193241458|M->I||0.17|Benign|0.08|tolerated|MGI:103562|Hsd11b1|hydroxysteroid 11-beta dehydrogenase 1 [Source:MGI Symbol;Acc:MGI:103562]|Heterozygous|Mice homozygous for disruptions in this gene display a normal morphology.  They have improved glucose tolerance and lower circulating lipid levels.|C|T|51|35.0|Non-synonymous|Unprocessed|APF-G1
1765713|IGL00788|X|93734909|F->L||0.04|Benign|0.39|tolerated|MGI:2147987|Pcyt1b|phosphate cytidylyltransferase 1, choline, beta isoform [Source:MGI Symbol;Acc:MGI:2147987]|Heterozygous|Homozygous null mice reduced fertility, abnormal ovaries with absent corpora lutea and follicles, benign ovarian tumors, seminiferous tubule degeneration, and reduced spermatogenesis.|T|C|51|38.0|Non-synonymous|Unprocessed|APF-G1
1765714|IGL00788|18|88972509|S->T|||Benign|0.57|tolerated|MGI:2179288|Rttn|rotatin [Source:MGI Symbol;Acc:MGI:2179288]|Heterozygous|Mice homozygous for an insertional mutation exhibit embryonic lethality and neurulation defects resulting in the arrest of gastrulation movements and abnormal left-right specification in the heart.|T|A|50|39.0|Non-synonymous|Unprocessed|APF-G1
1765715|IGL00788|7|90382698|D->E||||0.07|tolerated|MGI:1933366|Sytl2|synaptotagmin-like 2 [Source:MGI Symbol;Acc:MGI:1933366]|Heterozygous|Mice homozygous for a null allele display abnormal gastric surface mucus cell morphology and reduced basal mucin secretion from gastric cells|T|A|48|38.0|Non-synonymous|Unprocessed|APF-G1
1765716|IGL00788|1|12848449|D->G||0.02|Benign|0.02|deleterious|MGI:2138563|Sulf1|sulfatase 1 [Source:MGI Symbol;Acc:MGI:2138563]|Heterozygous|Mice homozygous for a null allele display a slight increase in mortality early in life.|A|G|29|38.0|Non-synonymous|Unprocessed|APF-G1
1765717|IGL00788|16|22018364|D->G||1.0|Probably damaging|0.13|tolerated|MGI:1923076|Senp2|SUMO/sentrin specific peptidase 2 [Source:MGI Symbol;Acc:MGI:1923076]|Heterozygous|Homozygous null mice are embryonic lethal due to placental defects resulting from abnormal trophoblast maturation.|A|G|28|35.0|Non-synonymous|Unprocessed|APF-G1
1765718|IGL00788|16|19957062|L->F|||Benign|0.7|tolerated|MGI:2686922|Klhl6|kelch-like 6 (Drosophila) [Source:MGI Symbol;Acc:MGI:2686922]|Heterozygous||G|A|24|39.5|Non-synonymous|Unprocessed|APF-G1
1765719|IGL00788|1|57885705|N->K||1.0|Probably damaging|0.03|deleterious|MGI:1914448|Spats2l|spermatogenesis associated, serine-rich 2-like [Source:MGI Symbol;Acc:MGI:1914448]|Heterozygous||T|A|21|40.0|Non-synonymous|Unprocessed|APF-G1
1765720|IGL00788|6|4624400|T->A||0.87|Possibly damaging|0.02|deleterious|MGI:2384865|Casd1|CAS1 domain containing 1 [Source:MGI Symbol;Acc:MGI:2384865]|Heterozygous||A|G|21|37.0|Non-synonymous|Unprocessed|APF-G1
1765721|IGL00788|1|65062091|R->Q||0.94|Possibly damaging|0.15|tolerated|MGI:88524|Crygd|crystallin, gamma D [Source:MGI Symbol;Acc:MGI:88524]|Heterozygous|Heterozygotes for a spontaneous mutation exhibit a dense nuclear cataract and mild microphthalmia by 2-months of age, followed by posterior capsular rupture into the posterior vitreous by 3-months. In homozygotes, the microphthalmia is more pronounced.|C|T|18|36.0|Non-synonymous|Unprocessed|APF-G1
1765722|IGL00788|5|16598230|Q->L||0.85|Possibly damaging||deleterious|MGI:96079|Hgf|hepatocyte growth factor [Source:MGI Symbol;Acc:MGI:96079]|Heterozygous|Homozygotes for targeted null mutations exhibit reduced embryonic livers, impaired migration of dermomyotome precursors affecting skeletal muscle formation, defective navigation of hypoglossal motor axons, abnormal placentas, and prenatal lethality.|A|T|18|40.0|Non-synonymous|Unprocessed|APF-G1
1765723|IGL00788|9|75168959|T->A||0.08|Benign|0.01|deleterious|MGI:105976|Myo5a|myosin VA [Source:MGI Symbol;Acc:MGI:105976]|Heterozygous|Mutations in this gene cause abnormal melanocyte structure, resulting in clumping of melanin pigment in hair of nonagouti mice, producing a gray coat color. Some alleles also produce a lethal or neurological phenotype.  Normal melanocyte structure and coat phenotype is restored in revertant alleles.|A|G|17|37.0|Non-synonymous|Unprocessed|APF-G1
1765724|IGL00788|5|4060480|E->G||1.0|Probably damaging||deleterious|MGI:2178217|Akap9|A kinase (PRKA) anchor protein (yotiao) 9 [Source:MGI Symbol;Acc:MGI:2178217]|Heterozygous||A|G|14|39.5|Non-synonymous|Unprocessed|APF-G1
1765725|IGL00788|5|100533555|E->G||1.0|Probably damaging|0.01|deleterious|MGI:1349414|Cops4|COP9 (constitutive photomorphogenic) homolog, subunit 4 (Arabidopsis thaliana) [Source:MGI Symbol;Acc:MGI:1349414]|Heterozygous||A|G|14|38.0|Non-synonymous|Unprocessed|APF-G1
1765726|IGL00788|5|105050997|E->D||0.08|Benign|0.59|tolerated|MGI:1923324|Gbp8|guanylate-binding protein 8 [Source:MGI Symbol;Acc:MGI:1923324]|Heterozygous||T|A|14|40.5|Non-synonymous|Unprocessed|APF-G1
1765727|IGL00788|5|21254024|V->M||0.84|Possibly damaging|0.01|deleterious|MGI:2442259|Pion|pigeon homolog (Drosophila) [Source:MGI Symbol;Acc:MGI:2442259]|Heterozygous||G|A|11|39.0|Non-synonymous|Unprocessed|APF-G1
1765728|IGL00788|7|25065393|H->Y||1.0|Probably damaging|0.04|deleterious|MGI:95818|Grik5|glutamate receptor, ionotropic, kainate 5 (gamma 2) [Source:MGI Symbol;Acc:MGI:95818]|Heterozygous|Mice homozygous for one allele display abnormal hippocampal synapse function. Mice homozygous for a second allele display decreased thermal nociception, increased startle response and increased susceptibility to pharmacologically induced seizures.|G|A|10|39.0|Non-synonymous|Unprocessed|APF-G1
1765730|IGL00788|16|49009069|Disrupted splicing||||||MGI:2146335|C330027c09rik|RIKEN cDNA C330027C09 gene [Source:MGI Symbol;Acc:MGI:2146335]|Heterozygous||T|A|301|40.0|Splice|Unprocessed|APF-G1
1765731|IGL00788|2|142210149|Disrupted splicing||||||MGI:1920149|Macrod2|MACRO domain containing 2 [Source:MGI Symbol;Acc:MGI:1920149]|Heterozygous||T|A|276|40.0|Splice|Unprocessed|APF-G1
1765732|IGL00788|12|56713812|Disrupted splicing||||||MGI:2445059|Slc25a21|solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21 [Source:MGI Symbol;Acc:MGI:2445059]|Heterozygous||A|T|140|39.0|Splice|Unprocessed|APF-G1
1765733|IGL00788|19|40337043|Disrupted splicing||||||MGI:700014|Sorbs1|sorbin and SH3 domain containing 1 [Source:MGI Symbol;Acc:MGI:700014]|Heterozygous|Mice homozygous for a null allele exhibit decreased triglyceride levels, altered glucose homeostasis, decreased white blood cells and resistance to developing glucose intolerance induced by a high fat diet.|A|G|50|38.0|Splice|Unprocessed|APF-G1
1765734|IGL00788|19|45932350|Disrupted splicing||||||MGI:1918867|9130011e15rik|RIKEN cDNA 9130011E15 gene [Source:MGI Symbol;Acc:MGI:1918867]|Heterozygous||C|T|46|40.0|Splice|Unprocessed|APF-G1
1765735|IGL00788|5|21221305|Disrupted splicing||||||MGI:2442259|Pion|pigeon homolog (Drosophila) [Source:MGI Symbol;Acc:MGI:2442259]|Heterozygous||G|A|39|38.0|Splice|Unprocessed|APF-G1
1765736|IGL00788|9|24462568|Disrupted splicing||||||MGI:1915685|Dpy19l1|dpy-19-like 1 (C. elegans) [Source:MGI Symbol;Acc:MGI:1915685]|Heterozygous||A|G|27|38.0|Splice|Unprocessed|APF-G1
1765737|IGL00788|7|25538573|Disrupted splicing||||||MGI:1347246|Ceacam2|carcinoembryonic antigen-related cell adhesion molecule 2 [Source:MGI Symbol;Acc:MGI:1347246]|Heterozygous||C|T|23|39.0|Splice|Unprocessed|APF-G1
1765738|IGL00788|2|52205732|Disrupted splicing||||||MGI:97292|Neb|nebulin [Source:MGI Symbol;Acc:MGI:97292]|Heterozygous||A|T|20|39.0|Splice|Unprocessed|APF-G1
1765739|IGL00788|9|21780479|Disrupted splicing||||||MGI:2384568|Kank2|KN motif and ankyrin repeat domains 2 [Source:MGI Symbol;Acc:MGI:2384568]|Heterozygous||A|G|19|36.0|Splice|Unprocessed|APF-G1
1766199|IGL00789|12|31760952|L->Q||0.65|Possibly damaging|0.15|tolerated|MGI:2145130|Cog5|component of oligomeric golgi complex 5 [Source:MGI Symbol;Acc:MGI:2145130]|Heterozygous||T|A|138|40.0|Non-synonymous|Unprocessed|APF-G1
1766200|IGL00789|10|10550812|N->S||0.05|Benign|0.2|tolerated|MGI:1915094|Rab32|RAB32, member RAS oncogene family [Source:MGI Symbol;Acc:MGI:1915094]|Heterozygous||T|C|44|37.0|Non-synonymous|Unprocessed|APF-G1
1766201|IGL00789|17|32470912|H->N||0.38|Benign|0.03|deleterious|MGI:2445210|Cyp4f39|cytochrome P450, family 4, subfamily f, polypeptide 39 [Source:MGI Symbol;Acc:MGI:2445210]|Heterozygous||C|A|41|37.0|Non-synonymous|Unprocessed|APF-G1
1766202|IGL00789|19|11185114|S->R||0.96|Probably damaging|0.01|deleterious|MGI:1920716|Ms4a13|membrane-spanning 4-domains, subfamily A, member 13 [Source:MGI Symbol;Acc:MGI:1920716]|Heterozygous||T|G|38|38.5|Non-synonymous|Unprocessed|APF-G1
1766203|IGL00789|15|8296869|V->M||1.0|Probably damaging|0.02|deleterious|MGI:1913976|Nipbl|Nipped-B homolog (Drosophila) [Source:MGI Symbol;Acc:MGI:1913976]|Heterozygous|Mice heterozygous for a gene trap allele exhibit increased mortality from birth to early adulthood, decreased weight, decreased adipose tissue, delayed ossification, craniofacial abnormalities, and abnormal hearing, behavior, and eye morphology.|C|T|34|39.0|Non-synonymous|Unprocessed|APF-G1
1766204|IGL00789|2|65126013|D->E||0.56|Possibly damaging|0.36|tolerated|MGI:2442894|Cobll1|Cobl-like 1 [Source:MGI Symbol;Acc:MGI:2442894]|Heterozygous||A|T|27|36.0|Non-synonymous|Unprocessed|APF-G1
1766205|IGL00789|7|102153971|V->A|||Benign|1.0|tolerated|MGI:109404|Nup98|nucleoporin 98 [Source:MGI Symbol;Acc:MGI:109404]|Heterozygous|Homozygotes for a null allele die in utero with a severe growth delay and improper gastrulation and nuclear pore complex assembly/function. Heterozygotes for another null allele show impaired IFN-mediated responses, reduced T and B cell subsets in lymphoid organs and altered T and B cell functions.|A|G|27|37.0|Non-synonymous|Unprocessed|APF-G1
1766206|IGL00789|11|33243249|T->I||0.12|Benign|0.04|deleterious|MGI:1929706|Ranbp17|RAN binding protein 17 [Source:MGI Symbol;Acc:MGI:1929706]|Heterozygous||G|A|24|38.0|Non-synonymous|Unprocessed|APF-G1
1766207|IGL00789|5|144285546|L->Stop|||N/A|||MGI:1914148|Baiap2l1|BAI1-associated protein 2-like 1 [Source:MGI Symbol;Acc:MGI:1914148]|Heterozygous||A|T|20|39.0|Non-synonymous|Unprocessed|APF-G1
1766214|IGL00789|5|144286069|Disrupted splicing||||||MGI:1914148|Baiap2l1|BAI1-associated protein 2-like 1 [Source:MGI Symbol;Acc:MGI:1914148]|Heterozygous||A|T|74|36.0|Splice|Unprocessed|APF-G1
1766215|IGL00789|2|71247955|Disrupted splicing||||||MGI:107750|Dync1i2|dynein cytoplasmic 1 intermediate chain 2 [Source:MGI Symbol;Acc:MGI:107750]|Heterozygous||G|A|16|39.0|Splice|Unprocessed|APF-G1
1766216|IGL00789|13|97173058|Disrupted splicing||||||MGI:2444783|Gfm2|G elongation factor, mitochondrial 2 [Source:MGI Symbol;Acc:MGI:2444783]|Heterozygous||A|G|13|33.0|Splice|Unprocessed|APF-G1
1766661|IGL00790|7|12494232|M->R||0.51|Possibly damaging||deleterious|MGI:1914620|Zfp606|zinc finger protein 606 [Source:MGI Symbol;Acc:MGI:1914620]|Heterozygous||T|G|71|39.0|Non-synonymous|Unprocessed|APF-G1
1766662|IGL00790|3|136935181|N->D||0.42|Benign|0.13|tolerated|MGI:107164|Ppp3ca|protein phosphatase 3, catalytic subunit, alpha isoform [Source:MGI Symbol;Acc:MGI:107164]|Heterozygous|Mice homozygous for a null allele exhibit decreased T cell proliferation and abnormal mossy fibers.|A|G|70|37.0|Non-synonymous|Unprocessed|APF-G1
1766663|IGL00790|3|94343409|D->V||1.0|Probably damaging|0.08|tolerated|MGI:1913448|Them5|thioesterase superfamily member 5 [Source:MGI Symbol;Acc:MGI:1913448]|Heterozygous||A|T|66|36.0|Non-synonymous|Unprocessed|APF-G1
1766664|IGL00790|4|43641612|V->D||0.09|Benign||deleterious|MGI:97372|Npr2|natriuretic peptide receptor 2 [Source:MGI Symbol;Acc:MGI:97372]|Heterozygous||T|A|65|36.0|Non-synonymous|Unprocessed|APF-G1
1766665|IGL00790|1|63306514|V->F||0.68|Possibly damaging|0.01|deleterious|MGI:1921134|Zdbf2|zinc finger, DBF-type containing 2 [Source:MGI Symbol;Acc:MGI:1921134]|Heterozygous||G|T|62|39.0|Non-synonymous|Unprocessed|APF-G1
1766666|IGL00790|1|65166122|Q->P||0.9|Possibly damaging||deleterious|MGI:96413|Idh1|isocitrate dehydrogenase 1 (NADP+), soluble [Source:MGI Symbol;Acc:MGI:96413]|Heterozygous|Electrophoretic variation has been shown in tissues of liver, kidney, spleen and muscle. Strains C57BL/6, C3H/He carry the a allele; DBA/2 carries the b allele; M.m. castaneus and M.m. molossinus carry the c allele; the d allele is found at low frequency in M. m. molossinus in Japan.|T|G|54|40.0|Non-synonymous|Unprocessed|APF-G1
1766667|IGL00790|17|33067387|V->A||||0.01|deleterious|MGI:1921292|4921501e09rik|RIKEN cDNA 4921501E09 gene [Source:MGI Symbol;Acc:MGI:1921292]|Heterozygous||A|G|42|38.0|Non-synonymous|Unprocessed|APF-G1
1766669|IGL00790|X|85621604|N->K||0.91|Possibly damaging|0.01|deleterious|MGI:1913974|Tab3|TGF-beta activated kinase 1/MAP3K7 binding protein 3 [Source:MGI Symbol;Acc:MGI:1913974]|Heterozygous||T|A|38|40.0|Non-synonymous|Unprocessed|APF-G1
1766670|IGL00790|9|59324065|D->G|||Benign|0.11|tolerated|MGI:2143311|Bbs4|Bardet-Biedl syndrome 4 (human) [Source:MGI Symbol;Acc:MGI:2143311]|Heterozygous|Homozygous null mice display partial embryonic lethality, low body weight before weaning, obesity and polyphagia after weaning, retinal degeneration, male infertility, absence of sperm cell flagella, impaired olfaction and abnormal olfactory epithelium and neurons.|T|C|36|37.0|Non-synonymous|Unprocessed|APF-G1
1766671|IGL00790|18|20094896|G->S||0.88|Possibly damaging||deleterious|MGI:109173|Dsc1|desmocollin 1 [Source:MGI Symbol;Acc:MGI:109173]|Heterozygous|Mutants with targeted disruptions of this gene have fragile epidermis, flaky skin, and defects in the epidermal barrier, leading to chronic dermatitis and display abnormal epidermal differentiation as indicated by hyperproliferation and overxpression of keratin 6 and 16.|C|T|33|39.0|Non-synonymous|Unprocessed|APF-G1
1766672|IGL00790|11|4918147|V->G||0.09|Benign||deleterious|MGI:1351333|Thoc5|THO complex 5 [Source:MGI Symbol;Acc:MGI:1351333]|Heterozygous|Mice homozygous for a knock-out allele exhibit embryonic lethality prior to E5.5.|T|G|31|36.0|Non-synonymous|Unprocessed|APF-G1
1766673|IGL00790|8|3429553|E->G||0.99|Probably damaging||deleterious|MGI:2142567|Arhgef18|rho/rac guanine nucleotide exchange factor (GEF) 18 [Source:MGI Symbol;Acc:MGI:2142567]|Heterozygous||A|G|29|37.0|Non-synonymous|Unprocessed|APF-G1
1766674|IGL00790|7|47981304|M->K||0.12|Benign||deleterious|MGI:3033100|Mrgpra4|MAS-related GPR, member A4 [Source:MGI Symbol;Acc:MGI:3033100]|Heterozygous||A|T|28|37.0|Non-synonymous|Unprocessed|APF-G1
1766675|IGL00790|6|136854495|Q->L||0.99|Probably damaging|0.01|deleterious|MGI:1202710|Art4|ADP-ribosyltransferase 4 [Source:MGI Symbol;Acc:MGI:1202710]|Heterozygous||T|A|26|36.0|Non-synonymous|Unprocessed|APF-G1
1766676|IGL00790|7|30038887|Y->Stop|||N/A|||MGI:99160|Zfp14|zinc finger protein 14 [Source:MGI Symbol;Acc:MGI:99160]|Heterozygous||G|T|26|36.0|Non-synonymous|Unprocessed|APF-G1
1766677|IGL00790|10|116507071|M->T||0.01|Benign|0.34|tolerated|MGI:1919318|Cnot2|CCR4-NOT transcription complex, subunit 2 [Source:MGI Symbol;Acc:MGI:1919318]|Heterozygous||A|G|22|38.0|Non-synonymous|Unprocessed|APF-G1
1766678|IGL00790|3|59319517|I->N||1.0|Probably damaging||deleterious|MGI:1923481|Igsf10|immunoglobulin superfamily, member 10 [Source:MGI Symbol;Acc:MGI:1923481]|Heterozygous||A|T|20|38.0|Non-synonymous|Unprocessed|APF-G1
1766679|IGL00790|17|35924859|N->I||1.0|Probably damaging||deleterious|MGI:1289273|Ppp1r10|protein phosphatase 1, regulatory subunit 10 [Source:MGI Symbol;Acc:MGI:1289273]|Heterozygous||A|T|19|38.0|Non-synonymous|Unprocessed|APF-G1
1766680|IGL00790|5|57721464|N->I||1.0|Probably damaging||deleterious|MGI:1860487|Pcdh7|protocadherin 7 [Source:MGI Symbol;Acc:MGI:1860487]|Heterozygous||A|T|17|39.0|Non-synonymous|Unprocessed|APF-G1
1766681|IGL00790|8|72468246|I->T|||Benign|0.58|tolerated|MGI:106417|Cherp|calcium homeostasis endoplasmic reticulum protein [Source:MGI Symbol;Acc:MGI:106417]|Heterozygous||A|G|17|36.0|Non-synonymous|Unprocessed|APF-G1
1766682|IGL00790|12|40834391|S->P||1.0|Probably damaging|0.09|tolerated|MGI:1918006|Dock4|dedicator of cytokinesis 4 [Source:MGI Symbol;Acc:MGI:1918006]|Heterozygous||T|C|16|38.0|Non-synonymous|Unprocessed|APF-G1
1766683|IGL00790|2|122292300|D->V||0.4|Benign|0.12|tolerated|MGI:3036280|Duox2|dual oxidase 2 [Source:MGI Symbol;Acc:MGI:3036280]|Heterozygous||T|A|15|30.0|Non-synonymous|Unprocessed|APF-G1
1766684|IGL00790|2|118786278|C->S||0.96|Probably damaging|0.07|tolerated|MGI:2388733|Disp2|dispatched homolog 2 (Drosophila) [Source:MGI Symbol;Acc:MGI:2388733]|Heterozygous||T|A|14|37.0|Non-synonymous|Unprocessed|APF-G1
1766685|IGL00790|10|5862624|Q->R||1.0|Probably damaging||deleterious|MGI:1927469|Rgs17|regulator of G-protein signaling 17 [Source:MGI Symbol;Acc:MGI:1927469]|Heterozygous||A|G|12|40.0|Non-synonymous|Unprocessed|APF-G1
1766686|IGL00790|17|65984180|N->K||||0.97|tolerated|MGI:1914357|Ankrd12|ankyrin repeat domain 12 [Source:MGI Symbol;Acc:MGI:1914357]|Heterozygous||A|T|12|38.0|Non-synonymous|Unprocessed|APF-G1
1766687|IGL00790|8|69817011|Y->Stop|||N/A|||MGI:1926066|Gmip|Gem-interacting protein [Source:MGI Symbol;Acc:MGI:1926066]|Heterozygous||T|A|10|35.0|Non-synonymous|Unprocessed|APF-G1
1766693|IGL00790|1|151442712|Disrupted splicing||||||MGI:1916185|1190005f20rik|RIKEN cDNA 1190005F20 gene [Source:MGI Symbol;Acc:MGI:1916185]|Heterozygous|Mice homozygous for a gene trapped allele are viable and anatomically normal but display significantly impaired motor coordination and aberrant exploratory behavior.|T|C|193|39.0|Splice|Unprocessed|APF-G1
1766694|IGL00790|15|100513178|Disrupted splicing||||||MGI:98509|Tcfcp2|transcription factor CP2 [Source:MGI Symbol;Acc:MGI:98509]|Heterozygous||T|C|23|40.0|Splice|Unprocessed|APF-G1
1766695|IGL00790|1|98421200|Disrupted splicing||||||MGI:1918116|Slco6d1|solute carrier organic anion transporter family, member 6d1 [Source:MGI Symbol;Acc:MGI:1918116]|Heterozygous||T|A|21|40.0|Splice|Unprocessed|APF-G1
1766696|IGL00790|18|67134289|Disrupted splicing||||||MGI:95774|Gnal|guanine nucleotide binding protein, alpha stimulating, olfactory type [Source:MGI Symbol;Acc:MGI:95774]|Heterozygous|Homozygous for a targeted mutation fail to feed, and ~75% die within 2 days after birth. Rare survivors reach sexual maturity and mate but are hyperactive and anosmic, exhibitng severely reduced odor-evoked electrophysical responses and significantly perturbed maternal behaviors.|A|G|15|36.0|Splice|Unprocessed|APF-G1
1767168|IGL00791|13|62454464|N->K||0.11|Benign||deleterious|MGI:1918758|Zfp935|zinc finger protein 935 [Source:MGI Symbol;Acc:MGI:1918758]|Heterozygous||A|C|58|39.5|Non-synonymous|Unprocessed|APF-G1
1767169|IGL00791|5|48304032|Y->H|||Benign|0.16|tolerated|MGI:1315205|Slit2|slit homolog 2 (Drosophila) [Source:MGI Symbol;Acc:MGI:1315205]|Heterozygous|Homozygous mutants display perinatal lethality, abnormal ureteric bud development, multiple fused kidneys, multiple ureters, and hydroureter.|T|C|56|37.0|Non-synonymous|Unprocessed|APF-G1
1767170|IGL00791|1|74522374|V->A|||Benign|0.12|tolerated|MGI:1928902|Rqcd1|rcd1 (required for cell differentiation) homolog 1 (S. pombe) [Source:MGI Symbol;Acc:MGI:1928902]|Heterozygous||T|C|52|36.0|Non-synonymous|Unprocessed|APF-G1
1767171|IGL00791|15|63804435|I->N||0.02|Benign|0.02|deleterious|MGI:1933176|Gsdmc|gasdermin C [Source:MGI Symbol;Acc:MGI:1933176]|Heterozygous||A|T|44|39.0|Non-synonymous|Unprocessed|APF-G1
1767172|IGL00791|9|90227428|S->G|||Benign|0.27|tolerated|MGI:1914266|Tbc1d2b|TBC1 domain family, member 2B [Source:MGI Symbol;Acc:MGI:1914266]|Heterozygous||T|C|43|38.0|Non-synonymous|Unprocessed|APF-G1
1767173|IGL00791|7|18013353|T->A||0.35|Benign|0.09|tolerated|MGI:1917035|Ceacam13|carcinoembryonic antigen-related cell adhesion molecule 13 [Source:MGI Symbol;Acc:MGI:1917035]|Heterozygous||A|G|34|36.5|Non-synonymous|Unprocessed|APF-G1
1767174|IGL00791|2|130616377|A->S|||Benign|0.3|tolerated|MGI:2139469|Fastkd5|FAST kinase domains 5 [Source:MGI Symbol;Acc:MGI:2139469]|Heterozygous||C|A|23|36.0|Non-synonymous|Unprocessed|APF-G1
1767175|IGL00791|15|91779841|L->R||1.0|Probably damaging||deleterious|MGI:1913975|Lrrk2|leucine-rich repeat kinase 2 [Source:MGI Symbol;Acc:MGI:1913975]|Heterozygous|Mice homozygous for a knock-in allele exhibit impaired response to dopamine, amphetamine, and quinpirole.  Mice homozygous for one knock-out allele exhibit increased neurite growth. Mice homozygous for different knock-out alleles exhibit alopecia due to excessive grooming or kdiney atrophy.|T|G|22|35.5|Non-synonymous|Unprocessed|APF-G1
1767176|IGL00791|7|140001498|L->P||0.02|Benign|0.11|tolerated|MGI:1921487|Tubgcp2|tubulin, gamma complex associated protein 2 [Source:MGI Symbol;Acc:MGI:1921487]|Heterozygous||A|G|21|37.0|Non-synonymous|Unprocessed|APF-G1
1767177|IGL00791|12|21239648|M->L||0.19|Benign|0.01|deleterious|MGI:2685438|6530401g17rik|RIKEN cDNA 6530401G17 gene [Source:MGI Symbol;Acc:MGI:1923478]|Heterozygous||A|T|20|39.0|Non-synonymous|Unprocessed|APF-G1
1767178|IGL00791|3|129332082|T->A||0.66|Possibly damaging|0.04|deleterious|MGI:106645|Enpep|glutamyl aminopeptidase [Source:MGI Symbol;Acc:MGI:106645]|Heterozygous|Mice homozygous for a targeted null mutation are viable, fertile and morphologically unaffected with normal B and T cell development.|T|C|20|32.0|Non-synonymous|Unprocessed|APF-G1
1767179|IGL00791|12|59108299|E->G||0.38|Benign|0.18|tolerated|MGI:2159614|Mia2|melanoma inhibitory activity 2 [Source:MGI Symbol;Acc:MGI:2159614]|Heterozygous||A|G|19|37.0|Non-synonymous|Unprocessed|APF-G1
1767180|IGL00791|8|14894689|M->K|||Benign||deleterious|MGI:1349447|Cln8|ceroid-lipofuscinosis, neuronal 8 [Source:MGI Symbol;Acc:MGI:1349447]|Heterozygous|Homozygous mutants exhibit late-onset progressive motor neuron degeneration and retinal photoreceptor degeneration. Mutants accumulate proteolipid in neuronal cytoplasm, have hindlimb weakness and ataxia, and die at 9-14 months of age.|T|A|18|34.5|Non-synonymous|Unprocessed|APF-G1
1767181|IGL00791|10|91162558|S->T||0.64|Possibly damaging|0.15|tolerated|MGI:106920|Tmpo|thymopoietin [Source:MGI Symbol;Acc:MGI:106920]|Heterozygous|Mice homozygous null for a protein isoform generated from this locus have hyperproliferation of epidermal and erythroid progenitor cells that leads to thickened paws and increased crypt lengths in the colon.|A|T|17|38.0|Non-synonymous|Unprocessed|APF-G1
1767182|IGL00791|11|121221160|S->G|||Benign|0.45|tolerated|MGI:3605542|Hexdc|hexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing [Source:MGI Symbol;Acc:MGI:3605542]|Heterozygous||A|G|16|37.0|Non-synonymous|Unprocessed|APF-G1
1767183|IGL00791|19|7435069|L->P||1.0|Probably damaging||deleterious|MGI:1339970|Rtn3|reticulon 3 [Source:MGI Symbol;Acc:MGI:1339970]|Heterozygous||A|G|16|39.0|Non-synonymous|Unprocessed|APF-G1
1767184|IGL00791|13|33151884|V->E||1.0|Probably damaging|0.05|tolerated|MGI:894669|Serpinb9c|serine (or cysteine) peptidase inhibitor, clade B, member 9c [Source:MGI Symbol;Acc:MGI:894669]|Heterozygous||A|T|14|38.0|Non-synonymous|Unprocessed|APF-G1
1767185|IGL00791|15|76172937|S->P||0.96|Probably damaging||deleterious|MGI:1277961|Plec|plectin [Source:MGI Symbol;Acc:MGI:1277961]|Heterozygous|Targeted mutations of this gene result in neonatal death, skin blistering, impaired myofibril integrity, reduced hemidesmosome number, and disintegration of intercalated disks in the heart. Mice lacking isoform 1 are viable with no skin blistering but leukocyte recruitment to wounds is impaired.|A|G|11|34.0|Non-synonymous|Unprocessed|APF-G1
1767186|IGL00791|7|44845313|S->P||0.02|Benign|0.08|tolerated|MGI:2449973|Tbc1d17|TBC1 domain family, member 17 [Source:MGI Symbol;Acc:MGI:2449973]|Heterozygous||A|G|10|35.5|Non-synonymous|Unprocessed|APF-G1
1767189|IGL00791|3|36575287|Disrupted splicing||||||MGI:1918742|Bbs7|Bardet-Biedl syndrome 7 (human) [Source:MGI Symbol;Acc:MGI:1918742]|Heterozygous||T|C|59|37.0|Splice|Unprocessed|APF-G1
1767190|IGL00791|11|83488923|Disrupted splicing||||||MGI:1917689|Taf15|TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor [Source:MGI Symbol;Acc:MGI:1917689]|Heterozygous||A|G|39|38.0|Splice|Unprocessed|APF-G1
1767191|IGL00791|11|58893059|Disrupted splicing||||||MGI:99183|Zfp39|zinc finger protein 39 [Source:MGI Symbol;Acc:MGI:99183]|Heterozygous||T|A|16|37.0|Splice|Unprocessed|APF-G1
1767662|IGL00792|10|24877004|I->T||0.55|Possibly damaging||deleterious|MGI:1917458|Med23|mediator complex subunit 23 [Source:MGI Symbol;Acc:MGI:1917458]|Heterozygous||T|C|191|38.0|Non-synonymous|Unprocessed|APF-G1
1767663|IGL00792|4|108816859|S->L||0.97|Probably damaging|0.01|deleterious|MGI:1915312|Btf3l4|basic transcription factor 3-like 4 [Source:MGI Symbol;Acc:MGI:1915312]|Heterozygous||G|A|190|39.0|Non-synonymous|Unprocessed|APF-G1
1767664|IGL00792|5|67342109|N->K||1.0|Probably damaging|0.01|deleterious|MGI:1923690|Slc30a9|solute carrier family 30 (zinc transporter), member 9 [Source:MGI Symbol;Acc:MGI:1923690]|Heterozygous||T|A|184|38.0|Non-synonymous|Unprocessed|APF-G1
1767665|IGL00792|7|131097607|C->S||0.77|Possibly damaging|0.01|deleterious|MGI:106210|Dmbt1|deleted in malignant brain tumors 1 [Source:MGI Symbol;Acc:MGI:106210]|Heterozygous|Mice homozygous for one null allele display embryonic lethality and an abnormal inner cell mass.  Mice homozygous for a different null allele are viable and fertile with an increased susceptibility to induced colitis.|T|A|177|39.0|Non-synonymous|Unprocessed|APF-G1
1767666|IGL00792|9|101211301|K->E||0.45|Possibly damaging|0.14|tolerated|MGI:2442104|Ppp2r3a|protein phosphatase 2, regulatory subunit B'', alpha [Source:MGI Symbol;Acc:MGI:2442104]|Heterozygous||T|C|153|39.0|Non-synonymous|Unprocessed|APF-G1
1767667|IGL00792|8|72255755|D->G||0.26|Benign|0.12|tolerated|MGI:102776|Ap1m1|adaptor-related protein complex AP-1, mu subunit 1 [Source:MGI Symbol;Acc:MGI:102776]|Heterozygous|Homozygous mutation of this gene results in embryonic lethality around E13.5. Homozygous embryos display hemorrhage of the ventricles and spinal canal.|A|G|124|35.0|Non-synonymous|Unprocessed|APF-G1
1767668|IGL00792|2|29763405|D->V||0.86|Possibly damaging||deleterious|MGI:3650473|Gm13547|predicted gene 13547 [Source:MGI Symbol;Acc:MGI:3650473]|Heterozygous||A|T|123|36.0|Non-synonymous|Unprocessed|APF-G1
1767669|IGL00792|2|157120548|H->Q||1.0|Probably damaging||deleterious|MGI:1927468|Samhd1|SAM domain and HD domain, 1 [Source:MGI Symbol;Acc:MGI:1927468]|Heterozygous||A|T|109|38.0|Non-synonymous|Unprocessed|APF-G1
1767670|IGL00792|2|79657463|A->V||0.13|Benign|0.28|tolerated|MGI:1917849|Ssfa2|sperm specific antigen 2 [Source:MGI Symbol;Acc:MGI:1917849]|Heterozygous|Mice homozygous for a null mutation display decreased body weight, resistance to diet induced obesity, increased food intake, decreased adipose tissue mass, elevated metabolic rate, abnormal glucose homeostasis, and abnormal hormone levels.|C|T|98|37.0|Non-synonymous|Unprocessed|APF-G1
1767671|IGL00792|11|115417849|F->S||0.99|Probably damaging||deleterious|MGI:1918929|Atp5h|ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d [Source:MGI Symbol;Acc:MGI:1918929]|Heterozygous||A|G|96|38.0|Non-synonymous|Unprocessed|APF-G1
1767672|IGL00792|9|60687838|S->P||0.27|Benign|0.13|tolerated|MGI:2442689|Lrrc49|leucine rich repeat containing 49 [Source:MGI Symbol;Acc:MGI:2442689]|Heterozygous||A|G|77|36.0|Non-synonymous|Unprocessed|APF-G1
1767673|IGL00792|16|14410926|I->V||0.02|Benign|0.22|tolerated|MGI:102676|Abcc1|ATP-binding cassette, sub-family C (CFTR/MRP), member 1 [Source:MGI Symbol;Acc:MGI:102676]|Heterozygous|Mice homozygous for targeted mutations that inactivate the gene have a reduced response to inflammatory stimulus, increased levels of glutathione due to impaired metabolism, and are hypersensitive to the anticancer drug etoposide.|A|G|73|37.0|Non-synonymous|Unprocessed|APF-G1
1767674|IGL00792|3|103778160|S->R||0.01|Benign|0.05|deleterious|MGI:1314873|Hipk1|homeodomain interacting protein kinase 1 [Source:MGI Symbol;Acc:MGI:1314873]|Heterozygous|Homozygous null mice are viable and fertile, do not develop spontaneous tumors, and are resistant to DMBA-induced skin tumor formation.|G|T|62|37.0|Non-synonymous|Unprocessed|APF-G1
1767675|IGL00792|2|76725626|D->V||1.0|Probably damaging|||MGI:98864|Ttn|titin [Source:MGI Symbol;Acc:MGI:98864]|Heterozygous|Homozygous mutant mice show embryogenesis defects in frontonasal mass, first branchial arch and somites, and vascular, cardiac and skeletal muscle defects causing growth retardation, muscle weakness, abnormal posture, and premature death ranging from embryonic day 11.5 to 8 weeks of age.|T|A|58|37.0|Non-synonymous|Unprocessed|APF-G1
1767676|IGL00792|11|101178966|N->K||0.1|Benign|1.0|tolerated|MGI:1858201|Cntnap1|contactin associated protein-like 1 [Source:MGI Symbol;Acc:MGI:1858201]|Heterozygous|Homozygous mutant mice exhibit reduced body size and nervous system defects, including impaired balance, hypoactivity, and and ataxia.|C|A|57|37.0|Non-synonymous|Unprocessed|APF-G1
1767677|IGL00792|2|62645870|R->W||1.0|Probably damaging||deleterious|MGI:1918836|Ifih1|interferon induced with helicase C domain 1 [Source:MGI Symbol;Acc:MGI:1918836]|Heterozygous|Mice homozygous for a null allele have increased virus-associated morbidity and mortality, and decreased cytokine response to  several viral infection.|T|A|55|38.0|Non-synonymous|Unprocessed|APF-G1
1767678|IGL00792|4|41521684|V->A||0.03|Benign|0.33|tolerated|MGI:1919151|2310028h24rik|RIKEN cDNA 2310028H24 gene [Source:MGI Symbol;Acc:MGI:1919151]|Heterozygous||A|G|53|36.0|Non-synonymous|Unprocessed|APF-G1
1767679|IGL00792|7|30015072|R->G|||Benign|0.06|tolerated|MGI:2142347|Zfp568|zinc finger protein 568 [Source:MGI Symbol;Acc:MGI:2142347]|Heterozygous|Homozygous null mutants are embryonic lethal with growth arrest around E8.5-9.0.  Mutant embryo shows shortened anterior-posterior axial extension with defects in somites and midline structures including open gut tube, cardia bifida, and failure to close neural tube.|A|G|52|37.0|Non-synonymous|Unprocessed|APF-G1
1767680|IGL00792|4|56743944|Y->F||0.42|Benign|0.01|deleterious|MGI:1343051|Actl7a|actin-like 7a [Source:MGI Symbol;Acc:MGI:1343051]|Heterozygous||A|T|50|36.5|Non-synonymous|Unprocessed|APF-G1
1767681|IGL00792|6|41702012|N->K||1.0|Probably damaging|0.14|tolerated|MGI:1346053|Kel|Kell blood group [Source:MGI Symbol;Acc:MGI:1346053]|Heterozygous||G|T|47|39.0|Non-synonymous|Unprocessed|APF-G1
1767682|IGL00792|1|74611117|L->F|||Benign|0.07|tolerated|MGI:1920831|Stk36|serine/threonine kinase 36 (fused homolog, Drosophila) [Source:MGI Symbol;Acc:MGI:1920831]|Heterozygous|Homozygotes for one knock-out allele become runty and emaciated and die before 3 wks of age. Homozygotes for another knock-out allele show a similar growth arrest and mortality in addition to hydrocephalus, a domed head, ataxia, rhinitis, immature lungs and kidneys, and thymus and spleen atrophy.|G|T|45|37.0|Non-synonymous|Unprocessed|APF-G1
1767683|IGL00792|9|37408211|L->F||1.0|Probably damaging|0.06|tolerated|MGI:1921394|Robo4|roundabout homolog 4 (Drosophila) [Source:MGI Symbol;Acc:MGI:1921394]|Heterozygous||C|T|42|36.0|Non-synonymous|Unprocessed|APF-G1
1767684|IGL00792|13|109935395|K->E||0.89|Possibly damaging|0.16|tolerated|MGI:99555|Pde4d|phosphodiesterase 4D, cAMP specific [Source:MGI Symbol;Acc:MGI:99555]|Heterozygous|Homozygotes for targeted null mutations exhibit delayed growth, female infertility associated with impaired ovulation, and reduced postnatal viability.|A|G|40|38.0|Non-synonymous|Unprocessed|APF-G1
1767685|IGL00792|6|129516741|S->T||0.28|Benign||deleterious|MGI:2442838|D630042f21rik|RIKEN cDNA D630042F21 gene [Source:MGI Symbol;Acc:MGI:2442838]|Heterozygous||T|A|40|38.0|Non-synonymous|Unprocessed|APF-G1
1767686|IGL00792|8|70854716|L->F||0.66|Possibly damaging|0.76|tolerated|MGI:1933993|Kcnn1|potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1 [Source:MGI Symbol;Acc:MGI:1933993]|Heterozygous|Homozygous null mice display normal hippocampal morphology and afterhyperpolarization currents.|G|A|38|35.0|Non-synonymous|Unprocessed|APF-G1
1767687|IGL00792|16|4288539|F->L||1.0|Probably damaging|0.02|deleterious|MGI:108450|Adcy9|adenylate cyclase 9 [Source:MGI Symbol;Acc:MGI:108450]|Heterozygous|Mice homozygous for disruptions in this gene show an increased IgG1 response to ovalbumin challenge.|A|G|34|37.0|Non-synonymous|Unprocessed|APF-G1
1767688|IGL00792|10|81078599|L->Stop|||N/A|||MGI:1354165|Thop1|thimet oligopeptidase 1 [Source:MGI Symbol;Acc:MGI:1354165]|Heterozygous||T|A|33|37.0|Non-synonymous|Unprocessed|APF-G1
1767689|IGL00792|3|95785104|S->P|||Benign|0.52|tolerated|MGI:1922387|Rprd2|regulation of nuclear pre-mRNA domain containing 2 [Source:MGI Symbol;Acc:MGI:1922387]|Heterozygous||A|G|32|38.5|Non-synonymous|Unprocessed|APF-G1
1767690|IGL00792|12|86140066|Q->L||0.11|Benign|0.3|tolerated|MGI:1923661|1700019e19rik|RIKEN cDNA 1700019E19 gene [Source:MGI Symbol;Acc:MGI:1923661]|Heterozygous||A|T|31|37.0|Non-synonymous|Unprocessed|APF-G1
1767691|IGL00792|3|100888347|V->A||1.0|Probably damaging||deleterious|MGI:3039619|Vtcn1|V-set domain containing T cell activation inhibitor 1 [Source:MGI Symbol;Acc:MGI:3039619]|Heterozygous||T|C|31|38.0|Non-synonymous|Unprocessed|APF-G1
1767692|IGL00792|11|99556546|Y->Stop|||N/A|||MGI:1913958|Krtap3-2|keratin associated protein 3-2 [Source:MGI Symbol;Acc:MGI:1913958]|Heterozygous||A|T|28|35.0|Non-synonymous|Unprocessed|APF-G1
1767693|IGL00792|1|60126009|V->L||0.07|Benign|0.11|tolerated|MGI:2182269|Carf|calcium response factor [Source:MGI Symbol;Acc:MGI:2182269]|Heterozygous|Mice homozygous for a null allele have aberrant learning and memory.|G|T|23|39.0|Non-synonymous|Unprocessed|APF-G1
1767694|IGL00792|2|156525019|R->C||1.0|Probably damaging|0.01|deleterious|MGI:103010|Epb4.1l1|erythrocyte protein band 4.1-like 1 [Source:MGI Symbol;Acc:MGI:103010]|Heterozygous|Mice homozygous for a knock-out allele exhibit normal glutamatergic synapse formation, AMPAR responses and long-term potentiation.|C|T|22|35.5|Non-synonymous|Unprocessed|APF-G1
1767696|IGL00792|12|38214389|Disrupted splicing||||||MGI:2442474|Dgkb|diacylglycerol kinase, beta [Source:MGI Symbol;Acc:MGI:2442474]|Heterozygous|Mice homozygous for a transposon distruption have defects in long term potentiation, synapase morphology, and in spatial reference and working memory.|G|A|158|39.0|Splice|Unprocessed|APF-G1
1767697|IGL00792|3|116885295|Disrupted splicing||||||MGI:108076|Frrs1|ferric-chelate reductase 1 [Source:MGI Symbol;Acc:MGI:108076]|Heterozygous||T|A|116|37.0|Splice|Unprocessed|APF-G1
1767698|IGL00792|18|36539596|Disrupted splicing||||||MGI:2443384|Slc4a9|solute carrier family 4, sodium bicarbonate cotransporter, member 9 [Source:MGI Symbol;Acc:MGI:2443384]|Heterozygous|Mice homozygous for a knock-out allele exhibit altered ion exchange in intestinal epithelia.|T|C|30|38.0|Splice|Unprocessed|APF-G1
1767699|IGL00792|10|126901100|Disrupted splicing||||||MGI:1916984|Xrcc6bp1|XRCC6 binding protein 1 [Source:MGI Symbol;Acc:MGI:1916984]|Heterozygous||A|T|12|37.5|Splice|Unprocessed|APF-G1
1768185|IGL00793|14|56602877|A->S||0.29|Benign|0.55|tolerated|MGI:2685589|Parp4|poly (ADP-ribose) polymerase family, member 4 [Source:MGI Symbol;Acc:MGI:2685589]|Heterozygous||G|T|208|37.0|Non-synonymous|Unprocessed|APF-G1
1768186|IGL00793|17|53665824|N->S|||Benign|0.85|tolerated|MGI:1343094|Kat2b|K(lysine) acetyltransferase 2B [Source:MGI Symbol;Acc:MGI:1343094]|Heterozygous|Mice homozygous for a null allele exhibit no abrnomal phenotype.|A|G|195|38.0|Non-synonymous|Unprocessed|APF-G1
1768187|IGL00793|12|51367762|S->T|||Benign|0.46|tolerated|MGI:2444298|G2e3|G2/M-phase specific E3 ubiquitin ligase [Source:MGI Symbol;Acc:MGI:2444298]|Heterozygous|Embryos homozygous for a gene trap allele that inactivates this gene die prior to implantation due to massive apoptosis which results in involution of the blastocyst.|T|A|138|39.0|Non-synonymous|Unprocessed|APF-G1
1768188|IGL00793|4|134828206|S->P||0.9|Possibly damaging|0.14|tolerated|MGI:1913396|Tmem57|transmembrane protein 57 [Source:MGI Symbol;Acc:MGI:1913396]|Heterozygous||A|G|136|37.0|Non-synonymous|Unprocessed|APF-G1
1768189|IGL00793|7|38106301|V->G|||Benign|0.48|tolerated|MGI:88316|Ccne1|cyclin E1 [Source:MGI Symbol;Acc:MGI:88316]|Heterozygous|Mice homozygous for disruptions in this gene display no abnormal phenotype.|A|C|112|37.0|Non-synonymous|Unprocessed|APF-G1
1768190|IGL00793|5|20896155|V->I|||Benign|0.58|tolerated|MGI:3036237|Rsbn1l|round spermatid basic protein 1-like [Source:MGI Symbol;Acc:MGI:3036237]|Heterozygous||C|T|93|39.0|Non-synonymous|Unprocessed|APF-G1
1768191|IGL00793|3|135884733|I->V||0.08|Benign|1.0|tolerated|MGI:1914797|Slc39a8|solute carrier family 39 (metal ion transporter), member 8 [Source:MGI Symbol;Acc:MGI:1914797]|Heterozygous||A|G|75|39.0|Non-synonymous|Unprocessed|APF-G1
1768192|IGL00793|4|107217889|D->G||1.0|Probably damaging||deleterious|MGI:3652166|Ldlrad1|low density lipoprotein receptor class A domain containing 1 [Source:MGI Symbol;Acc:MGI:3652166]|Heterozygous||A|G|71|37.0|Non-synonymous|Unprocessed|APF-G1
1768193|IGL00793|11|53411990|T->A||1.0|Probably damaging||deleterious|MGI:2136171|Aff4|AF4/FMR2 family, member 4 [Source:MGI Symbol;Acc:MGI:2136171]|Heterozygous|Homozygous null mice display embryonic and neonatal lethality with incomplete penetrance, abnormal respiration, and shrunken alveoli. Surviving males are infertile with azoospermia and arrest of spermatogenesis but, do not develop hematological abnormalities.|A|G|60|38.0|Non-synonymous|Unprocessed|APF-G1
1768194|IGL00793|12|75114346|V->F||0.98|Probably damaging|0.02|deleterious|MGI:3584508|Kcnh5|potassium voltage-gated channel, subfamily H (eag-related), member 5 [Source:MGI Symbol;Acc:MGI:3584508]|Heterozygous||C|A|57|37.0|Non-synonymous|Unprocessed|APF-G1
1768195|IGL00793|14|103126753|V->D||0.14|Benign||deleterious|MGI:2179432|Mycbp2|MYC binding protein 2 [Source:MGI Symbol;Acc:MGI:2179432]|Heterozygous|Mice homozygous for a targeted allele exhibit neonatal lethality, defective diaphragm innervation, abnormal brain morphology and defective axonal guidance.|A|T|57|37.0|Non-synonymous|Unprocessed|APF-G1
1768196|IGL00793|7|110628581|Y->C||1.0|Probably damaging|0.18|tolerated|MGI:108058|Adm|adrenomedullin [Source:MGI Symbol;Acc:MGI:108058]|Heterozygous|Homozygotes for a targeted null mutation exhibit cardiovascular defects, hyrdops fetalis, and lethality at midgestation.|A|G|57|31.0|Non-synonymous|Unprocessed|APF-G1
1768197|IGL00793|4|109087431|I->V|||Benign|0.59|tolerated|MGI:1923784|Osbpl9|oxysterol binding protein-like 9 [Source:MGI Symbol;Acc:MGI:1923784]|Heterozygous||T|C|54|37.0|Non-synonymous|Unprocessed|APF-G1
1768198|IGL00793|8|65014091|Y->N||0.04|Benign||deleterious|MGI:2387432|Trim61|tripartite motif-containing 61 [Source:MGI Symbol;Acc:MGI:2387432]|Heterozygous||A|T|54|39.0|Non-synonymous|Unprocessed|APF-G1
1768199|IGL00793|16|78334227|Y->Stop|||N/A|||MGI:1201679|Cxadr|coxsackie virus and adenovirus receptor [Source:MGI Symbol;Acc:MGI:1201679]|Heterozygous|Homozygous null mice display embryonic lethality with focal cardiomyocyte apoptosis and extensive thoracic hemorrhaging.|C|A|49|38.0|Non-synonymous|Unprocessed|APF-G1
1768200|IGL00793|2|119180960|E->G|||Benign|0.25|tolerated|MGI:1916658|Dnajc17|DnaJ (Hsp40) homolog, subfamily C, member 17 [Source:MGI Symbol;Acc:MGI:1916658]|Heterozygous|Mice homozygous for a gene trapped allele die before implantation.|T|C|46|38.0|Non-synonymous|Unprocessed|APF-G1
1768201|IGL00793|9|108397406|D->G||0.99|Probably damaging||deleterious|MGI:2148248|1700102p08rik|RIKEN cDNA 1700102P08 gene [Source:MGI Symbol;Acc:MGI:2148248]|Heterozygous||A|G|46|38.5|Non-synonymous|Unprocessed|APF-G1
1768202|IGL00793|15|98125594|V->A||0.19|Benign|0.78|tolerated|MGI:97548|Pfkm|phosphofructokinase, muscle [Source:MGI Symbol;Acc:MGI:97548]|Heterozygous|Mice homozygous for a gene trapped allele exhibit abnormal glucose homeostasis.  Mice homozygous for a knock-out allele exhibit premature death, exercise intolerance, abnormal glucose homeostasis, cardiomegaly, splenomegaly, and abnormal muscle morphology and physiology.|T|C|45|38.0|Non-synonymous|Unprocessed|APF-G1
1768203|IGL00793|5|26104155|R->G||0.99|Probably damaging||deleterious|MGI:3036277|5031410i06rik|RIKEN cDNA 5031410I06 gene [Source:MGI Symbol;Acc:MGI:3036277]|Heterozygous||T|C|45|37.0|Non-synonymous|Unprocessed|APF-G1
1768204|IGL00793|9|98585004|T->A|||Benign|0.81|tolerated|MGI:1354962|Copb2|coatomer protein complex, subunit beta 2 (beta prime) [Source:MGI Symbol;Acc:MGI:1354962]|Heterozygous||A|G|44|38.0|Non-synonymous|Unprocessed|APF-G1
1768205|IGL00793|12|83723018|S->T||0.58|Possibly damaging|0.19|tolerated|MGI:1202717|Psen1|presenilin 1 [Source:MGI Symbol;Acc:MGI:1202717]|Heterozygous|Homozygotes for targeted null mutations exhibit deformed axial skeletons, reduced Notch signaling, impaired brain growth with a deficiency of neural stem cells, cerebral hemorrhages, inhibited cleavage of amyloid precursor protein, and perinatal death.|T|A|39|37.0|Non-synonymous|Unprocessed|APF-G1
1768206|IGL00793|2|153672502|M->K||0.98|Probably damaging|0.04|deleterious|MGI:1261819|Dnmt3b|DNA methyltransferase 3B [Source:MGI Symbol;Acc:MGI:1261819]|Heterozygous|Homozygotes for a targeted null mutation exhibit growth retardation and rostral neural tube defects, and die prenatally. Mutants exhibit slight under-methylation of endogenous viral DNA and substantial demethylation of minor satellite DNA.|T|A|31|37.0|Non-synonymous|Unprocessed|APF-G1
1768207|IGL00793|10|115416874|V->A||0.95|Probably damaging|||MGI:2446143|Zfc3h1|zinc finger, C3H1-type containing [Source:MGI Symbol;Acc:MGI:2446143]|Heterozygous||T|C|26|38.0|Non-synonymous|Unprocessed|APF-G1
1768208|IGL00793|9|24254693|R->L||1.0|Probably damaging||deleterious|MGI:2441738|Npsr1|neuropeptide S receptor 1 [Source:MGI Symbol;Acc:MGI:2441738]|Heterozygous|Mice homozygous for a knock-out allele exhibit decreased airway resistance when treated with high concentrations of U-46619.|G|T|25|38.0|Non-synonymous|Unprocessed|APF-G1
1768209|IGL00793|11|118990545|N->I||1.0|Probably damaging||deleterious|MGI:3027917|Enpp7|ectonucleotide pyrophosphatase/phosphodiesterase 7 [Source:MGI Symbol;Acc:MGI:3027917]|Heterozygous||A|T|23|37.0|Non-synonymous|Unprocessed|APF-G1
1768210|IGL00793|10|127542205|V->A||||0.05|tolerated|MGI:96828|Lrp1|low density lipoprotein receptor-related protein 1 [Source:MGI Symbol;Acc:MGI:96828]|Heterozygous|Mice homozygous for a null allele exhibit lethality during late organogenesis.|A|G|17|37.0|Non-synonymous|Unprocessed|APF-G1
1768211|IGL00793|4|154152639|S->P||1.0|Probably damaging|0.02|deleterious|MGI:1891749|Wdr8|WD repeat domain 8 [Source:MGI Symbol;Acc:MGI:1891749]|Heterozygous||T|C|17|35.0|Non-synonymous|Unprocessed|APF-G1
1768212|IGL00793|1|70299650|C->R||1.0|Probably damaging|0.01|deleterious|MGI:1913972|Spag16|sperm associated antigen 16 [Source:MGI Symbol;Acc:MGI:1913972]|Heterozygous|Chimeric males carrying one copy of the mutated allele have impaired spermatogenesis, a significant loss of germ cells at the round spermatid stage, and disorganized sperm axoneme structure. No offspring carrying the mutated allele are produced from matings using male chimeras.|T|C|11|38.0|Non-synonymous|Unprocessed|APF-G1
1768214|IGL00793|4|135506407|Disrupted splicing||||||MGI:1926056|4930555i21rik|RIKEN cDNA 4930555I21 gene [Source:MGI Symbol;Acc:MGI:1926056]|Heterozygous||A|G|49|38.0|Splice|Unprocessed|APF-G1
1768215|IGL00793|9|103226143|Disrupted splicing||||||MGI:98821|Trf|transferrin [Source:MGI Symbol;Acc:MGI:98821]|Heterozygous|Homozygotes for a spontaneous mutation exhibit refractory iron-deficient, hypochromic, microcytic anemia with iron-loading in the liver, pancreas, heart and brain. Mutants usually die by two weeks of age. Heterozygotes show minor increases in iron stores.|A|G|45|39.0|Splice|Unprocessed|APF-G1
1768216|IGL00793|8|24837830|Disrupted splicing||||||MGI:2653822|Adam32|a disintegrin and metallopeptidase domain 32 [Source:MGI Symbol;Acc:MGI:2653822]|Heterozygous||A|T|35|37.0|Splice|Unprocessed|APF-G1
1768217|IGL00793|7|4628757|Disrupted splicing||||||MGI:1915505|Tmem86b|transmembrane protein 86B [Source:MGI Symbol;Acc:MGI:1915505]|Heterozygous||A|G|10|38.0|Splice|Unprocessed|APF-G1
1768718|IGL00794|9|66434189|D->G||0.05|Benign|0.37|tolerated|MGI:2384589|Herc1|hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1 [Source:MGI Symbol;Acc:MGI:2384589]|Heterozygous|Homozygotes for this spontaneous mutation exhibit an abnormal cerebellar Purkinje cell layer and Purkinje cell degeneration.|A|G|72|38.0|Non-synonymous|Unprocessed|APF-G1
1768719|IGL00794|2|76852135|T->A|||Unknown|||MGI:98864|Ttn|titin [Source:MGI Symbol;Acc:MGI:98864]|Heterozygous|Homozygous mutant mice show embryogenesis defects in frontonasal mass, first branchial arch and somites, and vascular, cardiac and skeletal muscle defects causing growth retardation, muscle weakness, abnormal posture, and premature death ranging from embryonic day 11.5 to 8 weeks of age.|T|C|61|38.0|Non-synonymous|Unprocessed|APF-G1
1768720|IGL00794|8|66512995|F->L||0.97|Probably damaging|0.05|tolerated|MGI:1921669|Tktl2|transketolase-like 2 [Source:MGI Symbol;Acc:MGI:1921669]|Heterozygous||T|C|49|38.0|Non-synonymous|Unprocessed|APF-G1
1768721|IGL00794|13|100219682|S->A||0.25|Benign|0.88|tolerated|MGI:1298220|Naip5|NLR family, apoptosis inhibitory protein 5 [Source:MGI Symbol;Acc:MGI:1298220]|Heterozygous|This locus controls resistance to Legionella pneumophila, the organism responsible for Legionnaire's disease. Cultured peritoneal macrophages from A/J mice are susceptible, supporting bacterial proliferation; other strains, e.g., C57BL/6 are resistant.|A|C|47|39.0|Non-synonymous|Unprocessed|APF-G1
1768722|IGL00794|3|73639966|N->S||1.0|Probably damaging|0.59|tolerated|MGI:894278|Bche|butyrylcholinesterase [Source:MGI Symbol;Acc:MGI:894278]|Heterozygous|Mice homozygous for a targeted null mutation do not exhibit any overt abnormalities.|T|C|47|39.0|Non-synonymous|Unprocessed|APF-G1
1768723|IGL00794|19|16740868|M->K||0.95|Possibly damaging|0.01|deleterious|MGI:2444304|Vps13a|vacuolar protein sorting 13A (yeast) [Source:MGI Symbol;Acc:MGI:2444304]|Heterozygous|Aging mice homozygous for a knock-out allele display motor dysfunction and abnormal social interaction, hematologic anomalies including acanthocytosis, selective atrophy of the striatum with significant apoptosis and gliosis, and reduced homovanillic acid levels in midbrain.|A|T|46|39.0|Non-synonymous|Unprocessed|APF-G1
1768724|IGL00794|7|88281497|V->M||0.97|Probably damaging|0.07|tolerated|MGI:109553|Ctsc|cathepsin C [Source:MGI Symbol;Acc:MGI:109553]|Heterozygous|Homozygotes for some targeted null mutations exhibit cytotoxic lymphocytes with inactive granzymes A and B which are incapable of granule-mediated apoptosis. Mutant mast cells lack activated chymase activity.  Homozygotes for other alleles display a scruffy coat with age and behavioral abnormalities|G|A|43|37.0|Non-synonymous|Unprocessed|APF-G1
1768725|IGL00794|2|73362563|T->A||0.01|Benign|0.75|tolerated|MGI:1915776|Gpr155|G protein-coupled receptor 155 [Source:MGI Symbol;Acc:MGI:1915776]|Heterozygous||T|C|42|36.5|Non-synonymous|Unprocessed|APF-G1
1768726|IGL00794|9|22368439|D->V|||Benign|0.16|tolerated|MGI:1920174|Anln|anillin, actin binding protein [Source:MGI Symbol;Acc:MGI:1920174]|Heterozygous||T|A|42|39.0|Non-synonymous|Unprocessed|APF-G1
1768727|IGL00794|9|106040621|D->A||0.96|Probably damaging|0.07|tolerated|MGI:1915803|Col6a4|collagen, type VI, alpha 4 [Source:MGI Symbol;Acc:MGI:1915803]|Heterozygous||T|G|24|34.5|Non-synonymous|Unprocessed|APF-G1
1768728|IGL00794|11|105780060|D->G|||Benign|0.15|tolerated|MGI:2444121|Tanc2|tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 [Source:MGI Symbol;Acc:MGI:2444121]|Heterozygous|Mice homozygous for a gene trap vector die prior to E12.|A|G|20|37.5|Non-synonymous|Unprocessed|APF-G1
1768729|IGL00794|6|85348791|I->N||1.0|Probably damaging||deleterious|MGI:1098586|Rab11fip5|RAB11 family interacting protein 5 (class I) [Source:MGI Symbol;Acc:MGI:1098586]|Heterozygous||A|T|20|36.5|Non-synonymous|Unprocessed|APF-G1
1768730|IGL00794|1|78692170|I->T|||Benign|0.58|tolerated|MGI:1921455|Acsl3|acyl-CoA synthetase long-chain family member 3 [Source:MGI Symbol;Acc:MGI:1921455]|Heterozygous||T|C|19|38.0|Non-synonymous|Unprocessed|APF-G1
1768731|IGL00794|12|104389556|T->S||0.38|Benign|1.0|tolerated|MGI:98378|Serpina3m|serine (or cysteine) peptidase inhibitor, clade A, member 3M [Source:MGI Symbol;Acc:MGI:98378]|Heterozygous||A|T|17|36.0|Non-synonymous|Unprocessed|APF-G1
1768732|IGL00794|17|12903288|I->N||0.95|Probably damaging|0.04|deleterious|MGI:2685159|Pnldc1|poly(A)-specific ribonuclease (PARN)-like domain containing 1 [Source:MGI Symbol;Acc:MGI:2685159]|Heterozygous||A|T|16|39.0|Non-synonymous|Unprocessed|APF-G1
1768733|IGL00794|17|32418798|D->E|||Benign|0.42|tolerated|MGI:1928099|Pglyrp2|peptidoglycan recognition protein 2 [Source:MGI Symbol;Acc:MGI:1928099]|Heterozygous|Mice homozygous for disruption of this gene are viable and fertile with no gross developmental defects.  Very subtle immune system effects are seen.|A|T|16|37.5|Non-synonymous|Unprocessed|APF-G1
1768734|IGL00794|5|137619726|S->P||0.71|Possibly damaging|0.26|tolerated|MGI:1918426|Fbxo24|F-box protein 24 [Source:MGI Symbol;Acc:MGI:1918426]|Heterozygous||A|G|16|36.5|Non-synonymous|Unprocessed|APF-G1
1768735|IGL00794|4|122948875|I->M||0.69|Possibly damaging|0.04|deleterious|MGI:1923824|Mfsd2a|major facilitator superfamily domain containing 2A [Source:MGI Symbol;Acc:MGI:1923824]|Heterozygous||T|C|15|37.0|Non-synonymous|Unprocessed|APF-G1
1768736|IGL00794|2|22826863|A->V||0.26|Benign||deleterious|MGI:1861354|Apbb1ip|amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein [Source:MGI Symbol;Acc:MGI:1861354]|Heterozygous||C|T|14|38.0|Non-synonymous|Unprocessed|APF-G1
1768737|IGL00794|15|76189350|L->P|||Unknown||deleterious|MGI:1277961|Plec|plectin [Source:MGI Symbol;Acc:MGI:1277961]|Heterozygous|Targeted mutations of this gene result in neonatal death, skin blistering, impaired myofibril integrity, reduced hemidesmosome number, and disintegration of intercalated disks in the heart. Mice lacking isoform 1 are viable with no skin blistering but leukocyte recruitment to wounds is impaired.|A|G|13|34.0|Non-synonymous|Unprocessed|APF-G1
1768738|IGL00794|5|115582423|L->P||0.94|Possibly damaging|0.08|tolerated|MGI:2444248|Gcn1l1|GCN1 general control of amino-acid synthesis 1-like 1 (yeast) [Source:MGI Symbol;Acc:MGI:2444248]|Heterozygous||T|C|13|38.0|Non-synonymous|Unprocessed|APF-G1
1768739|IGL00794|4|43024583|I->T||0.99|Probably damaging||deleterious|MGI:1861452|Pigo|phosphatidylinositol glycan anchor biosynthesis, class O [Source:MGI Symbol;Acc:MGI:1861452]|Heterozygous||A|G|11|38.0|Non-synonymous|Unprocessed|APF-G1
1768743|IGL00794|4|87049938|Disrupted splicing||||||MGI:1923626|Slc24a2|solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 [Source:MGI Symbol;Acc:MGI:1923626]|Heterozygous|Homozygous mutation of this gene results in loss of long term potentiation and an increase in long term depression and deficits in motor learning and spatial working memory.|C|T|30|38.5|Splice|Unprocessed|APF-G1
1768744|IGL00794|14|60709575|Disrupted splicing||||||MGI:104838|Spata13|spermatogenesis associated 13 [Source:MGI Symbol;Acc:MGI:104838]|Heterozygous||T|A|15|31.0|Splice|Unprocessed|APF-G1
1769211|IGL00795|2|70982090|I->N||0.99|Probably damaging||deleterious|MGI:2385142|Mettl8|methyltransferase like 8 [Source:MGI Symbol;Acc:MGI:2385142]|Heterozygous||A|T|148|37.0|Non-synonymous|Unprocessed|APF-G1
1769212|IGL00795|2|109293020|N->I||1.0|Probably damaging||deleterious|MGI:2446977|Kif18a|kinesin family member 18A [Source:MGI Symbol;Acc:MGI:2446977]|Heterozygous||A|T|68|37.0|Non-synonymous|Unprocessed|APF-G1
1769213|IGL00795|1|58552179|E->K||0.74|Possibly damaging||deleterious|MGI:1098784|Fam126b|family with sequence similarity 126, member B [Source:MGI Symbol;Acc:MGI:1098784]|Heterozygous||C|T|67|40.0|Non-synonymous|Unprocessed|APF-G1
1769214|IGL00795|2|127821815|V->A|||Benign|1.0|tolerated|MGI:1100510|Bub1|budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1100510]|Heterozygous|Mice homozygous for a null mutation exhibit embryonic lethality prior to implantation.|A|G|56|39.0|Non-synonymous|Unprocessed|APF-G1
1769215|IGL00795|1|163060622|T->S||0.97|Probably damaging|0.18|tolerated|MGI:1925508|4921528o07rik|RIKEN cDNA 4921528O07 gene [Source:MGI Symbol;Acc:MGI:1925508]|Heterozygous||T|A|35|37.0|Non-synonymous|Unprocessed|APF-G1
1769216|IGL00795|2|152574745|D->G|||Benign|0.34|tolerated|MGI:2684967|Defb21|defensin beta 21 [Source:MGI Symbol;Acc:MGI:2684967]|Heterozygous||A|G|35|40.0|Non-synonymous|Unprocessed|APF-G1
1769217|IGL00795|7|114842154|L->P||0.99|Probably damaging|0.06|tolerated|MGI:1917942|Insc|inscuteable homolog (Drosophila) [Source:MGI Symbol;Acc:MGI:1917942]|Heterozygous||T|C|34|37.5|Non-synonymous|Unprocessed|APF-G1
1769218|IGL00795|19|27422358|Y->F||0.99|Probably damaging||deleterious|MGI:106253|D19bwg1357e|DNA segment, Chr 19, Brigham & Women's Genetics 1357 expressed [Source:MGI Symbol;Acc:MGI:106253]|Heterozygous||T|A|33|39.0|Non-synonymous|Unprocessed|APF-G1
1769219|IGL00795|2|153746314|D->G||1.0|Probably damaging||deleterious|MGI:891995|Mapre1|microtubule-associated protein, RP/EB family, member 1 [Source:MGI Symbol;Acc:MGI:891995]|Heterozygous||A|G|32|39.0|Non-synonymous|Unprocessed|APF-G1
1769220|IGL00795|6|132957591|T->I||0.97|Probably damaging|0.19|tolerated|MGI:2681280|Tas2r131|taste receptor, type 2, member 131 [Source:MGI Symbol;Acc:MGI:2681280]|Heterozygous||G|A|32|40.0|Non-synonymous|Unprocessed|APF-G1
1769221|IGL00795|6|147507807|D->Y||1.0|Probably damaging||deleterious|MGI:1914265|Ccdc91|coiled-coil domain containing 91 [Source:MGI Symbol;Acc:MGI:1914265]|Heterozygous||G|T|30|38.5|Non-synonymous|Unprocessed|APF-G1
1769222|IGL00795|8|72253509|N->S||1.0|Probably damaging|0.07|tolerated|MGI:102776|Ap1m1|adaptor-related protein complex AP-1, mu subunit 1 [Source:MGI Symbol;Acc:MGI:102776]|Heterozygous|Homozygous mutation of this gene results in embryonic lethality around E13.5. Homozygous embryos display hemorrhage of the ventricles and spinal canal.|A|G|26|38.5|Non-synonymous|Unprocessed|APF-G1
1769223|IGL00795|11|121616932|I->S|||Benign|0.44|tolerated|MGI:1919686|Tbcd|tubulin-specific chaperone d [Source:MGI Symbol;Acc:MGI:1919686]|Heterozygous||T|G|20|37.5|Non-synonymous|Unprocessed|APF-G1
1769224|IGL00795|5|26104155|R->G||0.99|Probably damaging||deleterious|MGI:3036277|5031410i06rik|RIKEN cDNA 5031410I06 gene [Source:MGI Symbol;Acc:MGI:3036277]|Heterozygous||T|C|19|38.0|Non-synonymous|Unprocessed|APF-G1
1769225|IGL00795|11|118093634|C->F||0.12|Benign|0.01|deleterious|MGI:1917176|Dnahc17|dynein, axonemal, heavy chain 17 [Source:MGI Symbol;Acc:MGI:1917176]|Heterozygous||C|A|12|36.0|Non-synonymous|Unprocessed|APF-G1
1769226|IGL00795|6|72616252|A->T||0.02|Benign|0.4|tolerated|MGI:105080|Tgoln1|trans-golgi network protein [Source:MGI Symbol;Acc:MGI:105080]|Heterozygous||C|T|12|36.5|Non-synonymous|Unprocessed|APF-G1
1769703|IGL00796|7|97031580|L->Q||0.17|Benign|0.39|tolerated|MGI:2142075|Nars2|asparaginyl-tRNA synthetase 2 (mitochondrial)(putative) [Source:MGI Symbol;Acc:MGI:2142075]|Heterozygous||T|A|153|41.0|Non-synonymous|Unprocessed|APF-G1
1769704|IGL00796|7|97031579|L->I|||Benign|0.31|tolerated|MGI:2142075|Nars2|asparaginyl-tRNA synthetase 2 (mitochondrial)(putative) [Source:MGI Symbol;Acc:MGI:2142075]|Heterozygous||C|A|150|41.0|Non-synonymous|Unprocessed|APF-G1
1769705|IGL00796|2|155209082|H->L||0.97|Probably damaging||deleterious|MGI:1202301|Itch|itchy, E3 ubiquitin protein ligase [Source:MGI Symbol;Acc:MGI:1202301]|Heterozygous|The <A HREF=http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:1856404>a<sup>18H</sup></A> inversion mutation carries a distal breakpoint between exons 1 and 2 of the Itch gene.  Mice homozygous for this mutation do not express a functional Itch gene product.|A|T|130|40.0|Non-synonymous|Unprocessed|APF-G1
1769706|IGL00796|6|5157014|M->K||0.15|Benign|0.03|deleterious|MGI:2442401|Ppp1r9a|protein phosphatase 1, regulatory (inhibitor) subunit 9A [Source:MGI Symbol;Acc:MGI:2442401]|Heterozygous|Mice homozygous for a knock-out allele exhibit defects in dopamine-mediated neuromodulation, deficient long-term potentiation at corticostriatal synapses, increased spontaneous excitatory post-synaptic current frequency, and enhanced locomotor activation in response to cocaine treatment.|T|A|86|40.0|Non-synonymous|Unprocessed|APF-G1
1769707|IGL00796|5|76319175|T->I||0.54|Possibly damaging|0.05|deleterious|MGI:1890655|Pdcl2|phosducin-like 2 [Source:MGI Symbol;Acc:MGI:1890655]|Heterozygous||G|A|45|40.0|Non-synonymous|Unprocessed|APF-G1
1769708|IGL00796|3|138450981|T->A||0.01|Benign|0.03|deleterious|MGI:87929|Adh5|alcohol dehydrogenase 5 (class III), chi polypeptide [Source:MGI Symbol;Acc:MGI:87929]|Heterozygous|Homozygous null mutants are viable with increased S-nitrosothiols in RBCs, increased susceptibility to various toxins, and abnormal blood pressure regulation under anesthesia.|A|G|37|38.0|Non-synonymous|Unprocessed|APF-G1
1769709|IGL00796|1|46211337|V->A||0.23|Benign|0.08|tolerated|MGI:2684953|Dnahc7b|dynein, axonemal, heavy chain 7B [Source:MGI Symbol;Acc:MGI:2684953]|Heterozygous||T|C|36|38.0|Non-synonymous|Unprocessed|APF-G1
1769710|IGL00796|1|63307205|M->T||0.04|Benign|0.05|tolerated|MGI:1921134|Zdbf2|zinc finger, DBF-type containing 2 [Source:MGI Symbol;Acc:MGI:1921134]|Heterozygous||T|C|30|39.0|Non-synonymous|Unprocessed|APF-G1
1769711|IGL00796|5|33600827|D->E||0.04|Benign|0.54|tolerated|MGI:1919225|Fam53a|family with sequence similarity 53, member A [Source:MGI Symbol;Acc:MGI:1919225]|Heterozygous||A|T|28|35.0|Non-synonymous|Unprocessed|APF-G1
1769712|IGL00796|10|21141799|Q->P|||Benign|0.19|tolerated|MGI:97249|Myb|myeloblastosis oncogene [Source:MGI Symbol;Acc:MGI:97249]|Heterozygous|Mice homozygous for deficient alleles of this gene display severe hematopoietic abnormalities. Red and white blood cells and platelets are all affected.|T|G|22|35.5|Non-synonymous|Unprocessed|APF-G1
1769713|IGL00796|11|107054550|L->P||0.99|Probably damaging|||MGI:2444008|Bptf|bromodomain PHD finger transcription factor [Source:MGI Symbol;Acc:MGI:2444008]|Heterozygous|Mice homozygous for a null mutation display embryonic lethality during organogenesis with embryonic growth arrest around early gastrulation and a greatly reduced ectoplacental cone.|A|G|20|37.0|Non-synonymous|Unprocessed|APF-G1
1769714|IGL00796|14|32570002|S->P|||Benign|0.18|tolerated|MGI:1100494|Ercc6|excision repair cross-complementing rodent repair deficiency, complementation group 6 [Source:MGI Symbol;Acc:MGI:1100494]|Heterozygous|Homozygous mutant mice exhibit UV sensitivity, inactivation of transcription-coupled repair, increased incidence of induced skin and eye tumors, circling behavior, impaired coordination and lower body weight.|T|C|20|36.0|Non-synonymous|Unprocessed|APF-G1
1769715|IGL00796|2|165292014|C->S||||||MGI:2153045|Elmo2|engulfment and cell motility 2, ced-12 homolog (C. elegans) [Source:MGI Symbol;Acc:MGI:2153045]|Heterozygous||A|T|20|37.0|Non-synonymous|Unprocessed|APF-G1
1769716|IGL00796|13|49557417|I->M||0.79|Possibly damaging||deleterious|MGI:1913945, MGI:1913586|Cenpp,aspn|asporin [Source:MGI Symbol;Acc:MGI:1913945],centromere protein P [Source:MGI Symbol;Acc:MGI:1913586]|Heterozygous||A|G|19|37.0|Non-synonymous|Unprocessed|APF-G1
1769717|IGL00796|11|120450564|I->L|||Benign|0.08|tolerated|MGI:97526|Pde6g|phosphodiesterase 6G, cGMP-specific, rod, gamma [Source:MGI Symbol;Acc:MGI:97526]|Heterozygous|Mice homozygous for disruptions in this gene have poorly developed photoreceptors that degenerate with age.|T|A|18|32.5|Non-synonymous|Unprocessed|APF-G1
1769718|IGL00796|4|136554247|A->V||1.0|Probably damaging||deleterious|MGI:1196256|Kdm1a|lysine (K)-specific demethylase 1A [Source:MGI Symbol;Acc:MGI:1196256]|Heterozygous|Mice homozygous for a null allele exhibit early embryonic lethality (E7.5) due to failure of egg cylinder elongation, and failure to gastrulate.|G|A|18|39.0|Non-synonymous|Unprocessed|APF-G1
1769719|IGL00796|17|71905142|N->I||1.0|Probably damaging||deleterious|MGI:103305|Alk|anaplastic lymphoma kinase [Source:MGI Symbol;Acc:MGI:103305]|Heterozygous||T|A|15|39.0|Non-synonymous|Unprocessed|APF-G1
1769720|IGL00796|15|76625149|T->A|||Benign|0.14|tolerated|MGI:1914164|Vps28|vacuolar protein sorting 28 (yeast) [Source:MGI Symbol;Acc:MGI:1914164]|Heterozygous||T|C|14|37.0|Non-synonymous|Unprocessed|APF-G1
1769721|IGL00796|4|8847271|N->K||0.35|Benign||deleterious|MGI:2444748|Chd7|chromodomain helicase DNA binding protein 7 [Source:MGI Symbol;Acc:MGI:2444748]|Heterozygous|Heterozygotes for mutations of this gene exhibit a variety of combinations of hyperactivity, circling, head-bobbing, semicircular canal defects, hearing loss, reduced size, and tail-kink.|T|A|14|38.0|Non-synonymous|Unprocessed|APF-G1
1769722|IGL00796|X|7631031|D->E||1.0|Probably damaging|0.79|tolerated|MGI:1859639|Cacna1f|calcium channel, voltage-dependent, alpha 1F subunit [Source:MGI Symbol;Acc:MGI:1859639]|Heterozygous|Homozygous or hemizygous mutation of this gene results in impaired eye electrophysiology, abnormal retinal neuronal layer, bipolar cell, and horizontal cell morphology, and impaired retinal synapse morphology.|T|A|12|39.5|Non-synonymous|Unprocessed|APF-G1
1769723|IGL00796|3|80710790|N->D||0.01|Benign|0.2|tolerated|MGI:95809|Gria2|glutamate receptor, ionotropic, AMPA2 (alpha 2) [Source:MGI Symbol;Acc:MGI:95809]|Heterozygous|Homozygotes for targeted null mutations exhibit epilepsy, deficient dendritic architecture, altered exploratory behavior, impaired motor and learning performance, and increased mortality.|T|C|11|40.0|Non-synonymous|Unprocessed|APF-G1
1769726|IGL00796|X|8458220|Disrupted splicing||||||MGI:2446771|Ssxb2|synovial sarcoma, X member B, breakpoint 2 [Source:MGI Symbol;Acc:MGI:2446771]|Heterozygous||A|G|23|39.0|Splice|Unprocessed|APF-G1
1769727|IGL00796|15|77796995|Disrupted splicing||||||MGI:107717|Myh9|myosin, heavy polypeptide 9, non-muscle [Source:MGI Symbol;Acc:MGI:107717]|Heterozygous|Homozygous null mice display embryonic lethality. Heterozygous null mice display hearing loss with incomplete penetrance but no kidney or hematopoietic defects. Mice homozygous for a conditional allele activated in T cells exhibit impaired T cell migration and adhesion.|A|T|13|35.0|Splice|Unprocessed|APF-G1
1770184|IGL00797|5|43281447|T->I||1.0|Probably damaging||deleterious|MGI:2442640|Cpeb2|cytoplasmic polyadenylation element binding protein 2 [Source:MGI Symbol;Acc:MGI:2442640]|Heterozygous||C|T|86|38.0|Non-synonymous|Unprocessed|APF-G1
1770185|IGL00797|5|43758401|L->F||1.0|Probably damaging|0.03|deleterious|MGI:2152883|Fbxl5|F-box and leucine-rich repeat protein 5 [Source:MGI Symbol;Acc:MGI:2152883]|Heterozygous||T|A|20|40.0|Non-synonymous|Unprocessed|APF-G1
1770186|IGL00797|11|87098679|I->V|||Benign|1.0|tolerated|MGI:2444496|Prr11|proline rich 11 [Source:MGI Symbol;Acc:MGI:2444496]|Heterozygous||T|C|18|41.0|Non-synonymous|Unprocessed|APF-G1
1770187|IGL00797|11|78273150|T->A||0.93|Possibly damaging|0.38|tolerated|MGI:1919753|2610507b11rik|RIKEN cDNA 2610507B11 gene [Source:MGI Symbol;Acc:MGI:1919753]|Heterozygous||A|G|14|38.5|Non-synonymous|Unprocessed|APF-G1
1770188|IGL00797|2|35284037|D->Y||1.0|Probably damaging|0.01|deleterious|MGI:95851|Gsn|gelsolin [Source:MGI Symbol;Acc:MGI:95851]|Heterozygous|Mice homozygous for disruptions in this gene display abnormalities in the immune system, platelet and platelet function, bone density, nervous and circulatory system.  In addition, there are background related effects on viability and mammary gland development.|G|T|12|38.0|Non-synonymous|Unprocessed|APF-G1
1770189|IGL00797|4|34721562|S->N||1.0|Probably damaging|0.01|deleterious|MGI:1916579|1700003m02rik|RIKEN cDNA 1700003M02 gene [Source:MGI Symbol;Acc:MGI:1916579]|Heterozygous||C|T|11|38.0|Non-synonymous|Unprocessed|APF-G1
1770192|IGL00797|7|18718275|Disrupted splicing||||0.06|tolerated|MGI:1891354|Psg22|pregnancy-specific glycoprotein 22 [Source:MGI Symbol;Acc:MGI:1891354]|Heterozygous||A|G|31|39.0|Splice|Unprocessed|APF-G1
1770193|IGL00797|8|3602115|Disrupted splicing||||||MGI:1916947|2310057j16rik|RIKEN cDNA 2310057J16 gene [Source:MGI Symbol;Acc:MGI:1916947]|Heterozygous||T|A|20|39.5|Splice|Unprocessed|APF-G1
1770194|IGL00797|15|91854543|Disrupted splicing||||||MGI:1859618|Smgc|submandibular gland protein C [Source:MGI Symbol;Acc:MGI:1859618]|Heterozygous||A|T|18|37.0|Splice|Unprocessed|APF-G1
1770195|IGL00797|13|55607193|Disrupted splicing||||||MGI:2384987|B4galt7|xylosylprotein beta1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I) [Source:MGI Symbol;Acc:MGI:2384987]|Heterozygous||A|T|10|38.0|Splice|Unprocessed|APF-G1
1770633|IGL00798|3|31034499|V->A||0.03|Benign|0.91|tolerated|MGI:99260|Prkci|protein kinase C, iota [Source:MGI Symbol;Acc:MGI:99260]|Heterozygous|Mice homozygous for disruptions of this gene die as embryos before E10.|T|C|230|40.0|Non-synonymous|Unprocessed|APF-G1
1770634|IGL00798|18|60391001|M->T|||Benign|1.0|tolerated|MGI:1926259|Iigp1|interferon inducible GTPase 1 [Source:MGI Symbol;Acc:MGI:1926259]|Heterozygous|Targeted deletion of this gene results in partial loss of IFN-gamma-mediated Toxoplasma gondii growth restriction in primary mouse astrocytes.|T|C|158|40.0|Non-synonymous|Unprocessed|APF-G1
1770635|IGL00798|11|73711560|N->K||0.01|Benign|0.44|tolerated|MGI:1923640|Zfp735|zinc finger protein 735 [Source:MGI Symbol;Acc:MGI:1923640]|Heterozygous||T|A|85|38.0|Non-synonymous|Unprocessed|APF-G1
1770636|IGL00798|5|70782283|R->W||1.0|Probably damaging||deleterious|MGI:103156|Gabrg1|gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 [Source:MGI Symbol;Acc:MGI:103156]|Heterozygous||G|A|74|38.0|Non-synonymous|Unprocessed|APF-G1
1770637|IGL00798|6|121671010|F->I||0.99|Probably damaging||deleterious|MGI:2449119|A2m|alpha-2-macroglobulin [Source:MGI Symbol;Acc:MGI:2449119]|Heterozygous||T|A|59|39.0|Non-synonymous|Unprocessed|APF-G1
1770638|IGL00798|5|150539463|S->R||0.84|Possibly damaging|0.02|deleterious|MGI:109337|Brca2|breast cancer 2 [Source:MGI Symbol;Acc:MGI:109337]|Heterozygous|Homozygous null mutants are embryonic lethal with abnormalities including growth retardation, neural tube defects, and mesoderm abnormalities; conditional mutations cause genetic instability and enhanced tumor formation; mutants with truncated BRCA2 protein survive, are small, infertile, show improper tissue differentiation and develop lymphomas and carcinomas.|T|G|39|38.0|Non-synonymous|Unprocessed|APF-G1
1770639|IGL00798|13|110398034|S->P|||Benign|1.0|tolerated|MGI:1099790|Plk2|polo-like kinase 2 (Drosophila) [Source:MGI Symbol;Acc:MGI:1099790]|Heterozygous|Inactivation of this gene results in impaired embryonic growth and placental defects due to increased cell proliferation.|T|C|29|39.0|Non-synonymous|Unprocessed|APF-G1
1770640|IGL00798|13|93441402|S->P|||Benign|0.27|tolerated|MGI:1913096|Jmy|junction-mediating and regulatory protein [Source:MGI Symbol;Acc:MGI:1913096]|Heterozygous||A|G|27|37.0|Non-synonymous|Unprocessed|APF-G1
1770641|IGL00798|4|34721562|S->N||1.0|Probably damaging|0.01|deleterious|MGI:1916579|1700003m02rik|RIKEN cDNA 1700003M02 gene [Source:MGI Symbol;Acc:MGI:1916579]|Heterozygous||C|T|26|37.0|Non-synonymous|Unprocessed|APF-G1
1770642|IGL00798|5|121795235|K->E||0.98|Probably damaging|||MGI:1277223|Atxn2|ataxin 2 [Source:MGI Symbol;Acc:MGI:1277223]|Heterozygous|Homozygous mice exhibit an enlarged fat pad, hepatic steatosis and enlarged seminal vesicles.  A mild defect in motor learning is seen, but no other notable behavioral or neurological defects are detectable.|A|G|25|34.0|Non-synonymous|Unprocessed|APF-G1
1770643|IGL00798|7|102147204|F->S||0.99|Probably damaging||deleterious|MGI:109404|Nup98|nucleoporin 98 [Source:MGI Symbol;Acc:MGI:109404]|Heterozygous|Homozygotes for a null allele die in utero with a severe growth delay and improper gastrulation and nuclear pore complex assembly/function. Heterozygotes for another null allele show impaired IFN-mediated responses, reduced T and B cell subsets in lymphoid organs and altered T and B cell functions.|A|G|24|38.0|Non-synonymous|Unprocessed|APF-G1
1770644|IGL00798|18|39486871|G->D||0.94|Possibly damaging|0.02|deleterious|MGI:95824|Nr3c1|nuclear receptor subfamily 3, group C, member 1 [Source:MGI Symbol;Acc:MGI:95824]|Heterozygous|Homozygous null mutants die at birth of respiratory failure with underdeveloped lungs, enlarged adrenals, elevated serum corticosterone and ACTH, and failed adrenaline synthesis. Mice with a point mutation have impaired gluconeogenesis and erythropoiesis.|C|T|12|36.5|Non-synonymous|Unprocessed|APF-G1
1770645|IGL00798|2|125188194|I->T||1.0|Probably damaging||deleterious|MGI:103150|Slc12a1|solute carrier family 12, member 1 [Source:MGI Symbol;Acc:MGI:103150]|Heterozygous|Mice homozygous for disruptions in this gene do not survive to weaning and suffer from various metabolic abnormalities related to kidney function. Mice homozygous for an ENU-induced allele exhibit kidney disease, impaired urinary excretion of metabolism products, polyuria, and kidney alterations.|T|C|12|36.5|Non-synonymous|Unprocessed|APF-G1
1770650|IGL00798|18|74654076|Disrupted splicing||||||MGI:106598|Myo5b|myosin VB [Source:MGI Symbol;Acc:MGI:106598]|Heterozygous||A|G|17|38.0|Splice|Unprocessed|APF-G1
1771121|IGL00799|1|128174963|L->Q||0.99|Probably damaging||deleterious|MGI:2448514|R3hdm1|R3H domain 1 (binds single-stranded nucleic acids) [Source:MGI Symbol;Acc:MGI:2448514]|Heterozygous||T|A|97|40.0|Non-synonymous|Unprocessed|APF-G1
1771122|IGL00799|15|55617508|L->Stop|||N/A|||MGI:2146005|Mtbp|Mdm2, transformed 3T3 cell double minute p53 binding protein [Source:MGI Symbol;Acc:MGI:2146005]|Heterozygous||T|A|88|38.0|Non-synonymous|Unprocessed|APF-G1
1771123|IGL00799|2|34699860|D->E|||Benign|1.0|tolerated|MGI:1913941|Gapvd1|GTPase activating protein and VPS9 domains 1 [Source:MGI Symbol;Acc:MGI:1913941]|Heterozygous||A|T|46|39.5|Non-synonymous|Unprocessed|APF-G1
1771124|IGL00799|10|5347878|I->V||0.01|Benign|0.51|tolerated|MGI:1927152|Syne1|synaptic nuclear envelope 1 [Source:MGI Symbol;Acc:MGI:1927152]|Heterozygous|Mice homozygous for an allele lacking the KASH domain exhibit neonatal and postnatal lethality, progressive muscular dystrophy, and limb weakness.|A|G|42|38.0|Non-synonymous|Unprocessed|APF-G1
1771125|IGL00799|5|129999381|Y->C||1.0|Probably damaging|0.01|deleterious|MGI:95872|Gusb|glucuronidase, beta [Source:MGI Symbol;Acc:MGI:95872]|Heterozygous||T|C|33|36.0|Non-synonymous|Unprocessed|APF-G1
1771126|IGL00799|1|136890798|D->V||0.13|Benign|0.01|deleterious|MGI:1346834|Nr5a2|nuclear receptor subfamily 5, group A, member 2 [Source:MGI Symbol;Acc:MGI:1346834]|Heterozygous|Mice homozygous for disruptions in this gene die around embryonic day 7.5.  Heterozygotes are essentially normal but with lower plasma cholesterol, increased bile acids, and shorter intestinal crypt length.|T|A|28|38.0|Non-synonymous|Unprocessed|APF-G1
1771127|IGL00799|13|92477853|K->N||1.0|Probably damaging|0.01|deleterious|MGI:1921192|Fam151b|family with sequence similarity 151, member B [Source:MGI Symbol;Acc:MGI:1921192]|Heterozygous||C|A|25|37.0|Non-synonymous|Unprocessed|APF-G1
1771128|IGL00799|4|144555273|H->Q||0.45|Possibly damaging|0.63|tolerated|MGI:3652194|Gm13124|predicted gene 13124 [Source:MGI Symbol;Acc:MGI:3652194]|Heterozygous||A|T|24|39.0|Non-synonymous|Unprocessed|APF-G1
1771129|IGL00799|6|115877536|S->P||0.72|Possibly damaging|0.04|deleterious|MGI:1932386|Ift122|intraflagellar transport 122 homolog (Chlamydomonas) [Source:MGI Symbol;Acc:MGI:1932386]|Heterozygous|Homozygotes for a null mutation display embryonic lethality during organogenesis with exencephaly, a ventralized caudal neural tube, preaxial polydactyly, abnormal cilia, and left-right patterning defects.|T|C|18|37.5|Non-synonymous|Unprocessed|APF-G1
1771131|IGL00799|4|58828047|I->F||0.95|Possibly damaging|0.01|deleterious|MGI:2140220|Ai314180|expressed sequence AI314180 [Source:MGI Symbol;Acc:MGI:2140220]|Heterozygous||T|A|17|40.0|Non-synonymous|Unprocessed|APF-G1
1771132|IGL00799|8|105677336|D->G|||Unknown|0.11|tolerated|MGI:109447|Ctcf|CCCTC-binding factor [Source:MGI Symbol;Acc:MGI:109447]|Heterozygous|Mice homozygous for a null allele die prior to E9.5.  Mice homozygous for a conditional allele activated in T cells exhibit a defect in the transition from immature single positive T cells to double positive T cells.|A|G|16|38.0|Non-synonymous|Unprocessed|APF-G1
1771133|IGL00799|1|75133281|I->N||0.92|Possibly damaging||deleterious|MGI:104516|Slc23a3|solute carrier family 23 (nucleobase transporters), member 3 [Source:MGI Symbol;Acc:MGI:104516]|Heterozygous||A|T|15|35.0|Non-synonymous|Unprocessed|APF-G1
1771134|IGL00799|8|109575618|F->L|||Benign|1.0|tolerated|MGI:96211|Hp|haptoglobin [Source:MGI Symbol;Acc:MGI:96211]|Heterozygous||A|G|15|35.0|Non-synonymous|Unprocessed|APF-G1
1771135|IGL00799|7|15963467|A->T||0.9|Possibly damaging|0.03|deleterious|MGI:2154274|Ehd2|EH-domain containing 2 [Source:MGI Symbol;Acc:MGI:2154274]|Heterozygous||C|T|13|35.0|Non-synonymous|Unprocessed|APF-G1
1771136|IGL00799|15|51976125|D->E||1.0|Probably damaging|0.02|deleterious|MGI:108016|Rad21|RAD21 homolog (S. pombe) [Source:MGI Symbol;Acc:MGI:108016]|Heterozygous|Mice homozygous for a targeted allele exhibit prenatal lethality, reduced male fertility, and produce oocytes that fail to maintain sister chromatids in the first mitosis following fertilization.|A|T|12|34.5|Non-synonymous|Unprocessed|APF-G1
1771137|IGL00799|16|44492955|D->E||0.91|Possibly damaging|0.13|tolerated|MGI:2151153|Boc|biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein [Source:MGI Symbol;Acc:MGI:2151153]|Heterozygous|Mice homozygous for a null mutation display abnormal commissural axon projections.|G|T|11|37.0|Non-synonymous|Unprocessed|APF-G1
1771138|IGL00799|2|74692442|S->G||1.0|Probably damaging|0.01|deleterious|MGI:96202|Hoxd10|homeobox D10 [Source:MGI Symbol;Acc:MGI:96202]|Heterozygous|Homozygotes for a targeted null mutation exhibit an abnormal gait associated with defects in sacral vertebrae (including homeotic transformations), hindlimb bones, and muscle innervation. These defects are sometimes seen in heterozygotes as well.|A|G|11|36.0|Non-synonymous|Unprocessed|APF-G1
1771139|IGL00799|2|35707775|I->V||0.33|Benign|0.16|tolerated|MGI:1916851|Dab2ip|disabled homolog 2 (Drosophila) interacting protein [Source:MGI Symbol;Acc:MGI:1916851]|Heterozygous|Mice homozygous for a knock-out allele exhibit impaired IRE1-mediated endoplasmic reticulum (ER) stress-induced responses.|A|G|10|39.0|Non-synonymous|Unprocessed|APF-G1
1771144|IGL00799|13|95657944|Disrupted splicing||||||MGI:2449975|Iqgap2|IQ motif containing GTPase activating protein 2 [Source:MGI Symbol;Acc:MGI:2449975]|Heterozygous|Mice homozygous for a null mutation display reduced survival with increased incidence of hepatocellular carcinomas, increased hepatocyte apoptosis, and hepatocyte mitochondrial abnormalities.|A|G|43|39.0|Splice|Unprocessed|APF-G1
1771145|IGL00799|3|135228917|Disrupted splicing||||||MGI:1098230|Cenpe|centromere protein E [Source:MGI Symbol;Acc:MGI:1098230]|Heterozygous|Mice homozygous for a knock-out allele display early embryonic lethality. Mutant embryos grown in culture exhibit inner cell mass growth defects and mitotic chromosome misalignment.|T|A|18|38.5|Splice|Unprocessed|APF-G1
1771616|IGL00800|12|113490442|V->A||0.39|Benign|0.76|tolerated|MGI:2444636|Adam6b|a disintegrin and metallopeptidase domain 6B [Source:MGI Symbol;Acc:MGI:2444636]|Heterozygous||T|C|138|38.0|Non-synonymous|Unprocessed|APF-G1
1771617|IGL00800|10|40239759|Q->Stop|||N/A|||MGI:1914489|Rpf2|ribosome production factor 2 homolog (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1914489]|Heterozygous||G|A|115|37.0|Non-synonymous|Unprocessed|APF-G1
1771618|IGL00800|12|91255664|K->E||0.12|Benign|0.03|deleterious|MGI:1922466|4930534b04rik|RIKEN cDNA 4930534B04 gene [Source:MGI Symbol;Acc:MGI:1922466]|Heterozygous||T|C|107|39.0|Non-synonymous|Unprocessed|APF-G1
1771619|IGL00800|10|58490704|D->E|||Benign|1.0|tolerated|MGI:894323|Ranbp2|RAN binding protein 2 [Source:MGI Symbol;Acc:MGI:894323]|Heterozygous|Mice homozygous for a gene trap allele display embryonic lethality. Heterozygous mice on some backgrounds display reduced ATP levels in the CNS, decreased glucose clearance, decreased weight gain on a high fat diet, and reduced scotopic responses.|T|A|61|39.0|Non-synonymous|Unprocessed|APF-G1
1771620|IGL00800|5|150980768|W->Stop|||N/A|||MGI:1101771|Kl|klotho [Source:MGI Symbol;Acc:MGI:1101771]|Heterozygous|Homozygous mutant mice have a short lifespan and growth retardation  with one allele homeostatic imbalances and soft tissue calcification are also seen. With a second allele abnormal cancellous bone and femur morphology are seen.|G|A|54|37.0|Non-synonymous|Unprocessed|APF-G1
1771621|IGL00800|7|120255390|I->L|||Benign|0.82|tolerated|MGI:2388708|Abca14|ATP-binding cassette, sub-family A (ABC1), member 14 [Source:MGI Symbol;Acc:MGI:2388708]|Heterozygous||A|T|42|39.0|Non-synonymous|Unprocessed|APF-G1
1771622|IGL00800|10|61205418|T->S|||Benign|0.69|tolerated|MGI:2179942|Adamts14|a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 14 [Source:MGI Symbol;Acc:MGI:2179942]|Heterozygous||T|A|23|37.0|Non-synonymous|Unprocessed|APF-G1
1771623|IGL00800|13|17728142|V->A||0.97|Probably damaging||deleterious|MGI:1916812|Cdk13|cyclin-dependent kinase 13 [Source:MGI Symbol;Acc:MGI:1916812]|Heterozygous||A|G|18|36.0|Non-synonymous|Unprocessed|APF-G1
1771624|IGL00800|15|101473860|H->Y|||Benign|0.11|tolerated|MGI:109362|Krt86|keratin 86 [Source:MGI Symbol;Acc:MGI:109362]|Heterozygous||C|T|15|37.0|Non-synonymous|Unprocessed|APF-G1
1771625|IGL00800|19|44298130|L->P||1.0|Probably damaging||deleterious|MGI:98240|Scd2|stearoyl-Coenzyme A desaturase 2 [Source:MGI Symbol;Acc:MGI:98240]|Heterozygous|Homozygous null mice display neonatal lethality with variable penetrance depending on stain background, impaired skin barrier function, abnormal epidermal morphology, and abnormal lipid homeostasis in the skin and liver.|T|C|15|40.0|Non-synonymous|Unprocessed|APF-G1
1771626|IGL00800|6|84149998|N->S||0.11|Benign|0.16|tolerated|MGI:1349385|Dysf|dysferlin [Source:MGI Symbol;Acc:MGI:1349385]|Heterozygous|Homozygotes display dystrophic muscle changes and progressive muscle weakness developing over time.|A|G|15|36.0|Non-synonymous|Unprocessed|APF-G1
1771627|IGL00800|2|131040283|S->P|||||deleterious|MGI:1341873|Gfra4|glial cell line derived neurotrophic factor family receptor alpha 4 [Source:MGI Symbol;Acc:MGI:1341873]|Heterozygous|Homozygotes for targeted null mutations are mice were viable, fertile, showed no overt anatomical defects.  Thyroid tissue calcitonin content was reduced in null homozygotes and rate of bone formation was enhanced when in 129/B6 hybrid background strain.|A|G|13|33.0|Non-synonymous|Unprocessed|APF-G1
1771628|IGL00800|15|9525109|T->P||0.98|Probably damaging|0.01|deleterious|MGI:96562|Il7r|interleukin 7 receptor [Source:MGI Symbol;Acc:MGI:96562]|Heterozygous||T|G|10|37.5|Non-synonymous|Unprocessed|APF-G1
1771629|IGL00800|4|117912308|D->N||0.53|Possibly damaging|0.03|deleterious|MGI:2385205|Ipo13|importin 13 [Source:MGI Symbol;Acc:MGI:2385205]|Heterozygous||C|T|10|37.0|Non-synonymous|Unprocessed|APF-G1
1771632|IGL00800|6|91741170|Disrupted splicing||||||MGI:98488|Slc6a6|solute carrier family 6 (neurotransmitter transporter, taurine), member 6 [Source:MGI Symbol;Acc:MGI:98488]|Heterozygous|Homozygous mutant mice have impaired vision associated with retinal degeneration. In addition to the visual defects, mutant mice exhibit reduced female fertility and decreased levels of taurine in a variety of tissues.|T|A|42|35.5|Splice|Unprocessed|APF-G1
1772130|IGL00801|5|52857211|V->D||0.99|Probably damaging||deleterious|MGI:1098673|Anapc4|anaphase promoting complex subunit 4 [Source:MGI Symbol;Acc:MGI:1098673]|Heterozygous||T|A|224|38.5|Non-synonymous|Unprocessed|APF-G1
1772131|IGL00801|12|72881386|T->A||0.05|Benign|0.42|tolerated|MGI:1923051|4930447c04rik|RIKEN cDNA 4930447C04 gene [Source:MGI Symbol;Acc:MGI:1923051]|Heterozygous||T|C|183|38.0|Non-synonymous|Unprocessed|APF-G1
1772132|IGL00801|5|73304566|Y->N||1.0|Probably damaging||deleterious|MGI:1915345|Ociad1|OCIA domain containing 1 [Source:MGI Symbol;Acc:MGI:1915345]|Heterozygous||T|A|117|35.0|Non-synonymous|Unprocessed|APF-G1
1772133|IGL00801|2|5866357|F->S||1.0|Probably damaging||deleterious|MGI:1858232|Nudt5|nudix (nucleoside diphosphate linked moiety X)-type motif 5 [Source:MGI Symbol;Acc:MGI:1858232]|Heterozygous||T|C|116|39.0|Non-synonymous|Unprocessed|APF-G1
1772134|IGL00801|7|118852644|V->A||0.2|Benign|1.0|tolerated|MGI:1913606|2310008h09rik|RIKEN cDNA 2310008H09 gene [Source:MGI Symbol;Acc:MGI:1913606]|Heterozygous||A|G|115|37.0|Non-synonymous|Unprocessed|APF-G1
1772135|IGL00801|3|116294844|S->Stop|||N/A|||MGI:2442676|Cdc14a|CDC14 cell division cycle 14 homolog A (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:2442676]|Heterozygous||G|T|109|37.0|Non-synonymous|Unprocessed|APF-G1
1772136|IGL00801|8|71965888|M->R||1.0|Probably damaging||deleterious|MGI:3583954|Zfp961|zinc finger protein 961 [Source:MGI Symbol;Acc:MGI:3583954]|Heterozygous||T|G|99|39.0|Non-synonymous|Unprocessed|APF-G1
1772137|IGL00801|16|43881189|K->E||0.5|Possibly damaging|0.01|deleterious|MGI:1922194|Qtrtd1|queuine tRNA-ribosyltransferase domain containing 1 [Source:MGI Symbol;Acc:MGI:1922194]|Heterozygous||T|C|96|38.0|Non-synonymous|Unprocessed|APF-G1
1772138|IGL00801|19|55233103|R->Q||0.55|Possibly damaging|0.31|tolerated|MGI:106025|Gucy2g|guanylate cyclase 2g [Source:MGI Symbol;Acc:MGI:106025]|Heterozygous|Mice homozygous for a null mutation are viable and fertile with no gross abnormalities and are protected against acute ischemia induced renal injury.|C|T|95|38.0|Non-synonymous|Unprocessed|APF-G1
1772139|IGL00801|13|99430097|E->K|||Unknown|0.04|deleterious|MGI:1306778|Mtap1b|microtubule-associated protein 1B [Source:MGI Symbol;Acc:MGI:1306778]|Heterozygous|Mice homozygous for one knock-out allele die prior to E8.5.  While mice homozygous for other knock-out alleles exhibit behavioral, visual system, and nervous system defects.|C|T|94|39.0|Non-synonymous|Unprocessed|APF-G1
1772140|IGL00801|9|108842576|V->A|||Benign|0.44|tolerated|MGI:1858236|Celsr3|cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila) [Source:MGI Symbol;Acc:MGI:1858236]|Heterozygous|Mice homozygous for a null allele exhibit neonatal lethality, abnormal neurvous system development, and abnormal respiratory system development.|T|C|92|35.0|Non-synonymous|Unprocessed|APF-G1
1772141|IGL00801|18|61499834|Y->H||1.0|Probably damaging||deleterious|MGI:3045339|Arhgef37|Rho guanine nucleotide exchange factor (GEF) 37 [Source:MGI Symbol;Acc:MGI:3045339]|Heterozygous||A|G|87|37.0|Non-synonymous|Unprocessed|APF-G1
1772142|IGL00801|13|49662228|D->G||0.02|Benign|0.21|tolerated|MGI:1918180|Nol8|nucleolar protein 8 [Source:MGI Symbol;Acc:MGI:1918180]|Heterozygous||A|G|75|37.0|Non-synonymous|Unprocessed|APF-G1
1772143|IGL00801|7|57488988|W->L||1.0|Probably damaging|0.03|deleterious|MGI:95617|Gabra5|gamma-aminobutyric acid (GABA) A receptor, subunit alpha 5 [Source:MGI Symbol;Acc:MGI:95617]|Heterozygous|Mice having disruptions in this gene display abnormalities in hearing and in ear structure.  Subtle abnormalities in learning and in conditioning have also been reported.|C|A|72|37.0|Non-synonymous|Unprocessed|APF-G1
1772144|IGL00801|15|6794534|V->I||0.99|Probably damaging|0.04|deleterious|MGI:1926007|Rictor|RPTOR independent companion of MTOR, complex 2 [Source:MGI Symbol;Acc:MGI:1926007]|Heterozygous|Mice homozygous for a null allele exhibit embryonic lethality during organogenesis associated with abnormal placental morphology.|G|A|66|37.0|Non-synonymous|Unprocessed|APF-G1
1772145|IGL00801|3|145648610|D->V||0.92|Possibly damaging|0.16|tolerated|MGI:88613|Cyr61|cysteine rich protein 61 [Source:MGI Symbol;Acc:MGI:88613]|Heterozygous|Targeted null mice die pre- or perinatally, and none survive beyond 24 hrs of birth.  About 30% of embryos die by E10.5 from defects in chorioallantoic fusion, whereas 70% die from placental vascular defects, including impaired allantoic vessel bifurcation, and loss of large-vessel integrity.|T|A|64|37.0|Non-synonymous|Unprocessed|APF-G1
1772146|IGL00801|14|111680665|M->V||0.11|Benign|0.01|deleterious|MGI:2679448|Slitrk5|SLIT and NTRK-like family, member 5 [Source:MGI Symbol;Acc:MGI:2679448]|Heterozygous||A|G|56|37.0|Non-synonymous|Unprocessed|APF-G1
1772147|IGL00801|4|112625991|M->L||0.71|Possibly damaging|0.21|tolerated|MGI:3649629|Skint2|selection and upkeep of intraepithelial T cells 2 [Source:MGI Symbol;Acc:MGI:3649629]|Heterozygous||A|T|55|39.0|Non-synonymous|Unprocessed|APF-G1
1772148|IGL00801|1|63303038|F->S||0.68|Possibly damaging|0.36|tolerated|MGI:1921134|Zdbf2|zinc finger, DBF-type containing 2 [Source:MGI Symbol;Acc:MGI:1921134]|Heterozygous||T|C|54|38.0|Non-synonymous|Unprocessed|APF-G1
1772149|IGL00801|12|101926508|S->P||0.56|Possibly damaging|0.03|deleterious|MGI:1099442|Atxn3|ataxin 3 [Source:MGI Symbol;Acc:MGI:1099442]|Heterozygous|Decreased exploratory behavior is reported for mice homozygous for a disruption of this marker.|A|G|54|35.0|Non-synonymous|Unprocessed|APF-G1
1772150|IGL00801|2|68117976|T->S||0.02|Benign||deleterious|MGI:1349403|B3galt1|UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 [Source:MGI Symbol;Acc:MGI:1349403]|Heterozygous||A|T|53|36.0|Non-synonymous|Unprocessed|APF-G1
1772151|IGL00801|9|118538926|L->Q||0.88|Possibly damaging||deleterious|MGI:1859646|Golga4|golgi autoantigen, golgin subfamily a, 4 [Source:MGI Symbol;Acc:MGI:1859646]|Heterozygous||T|A|51|38.0|Non-synonymous|Unprocessed|APF-G1
1772152|IGL00801|10|128803145|L->R||0.9|Possibly damaging||deleterious|MGI:1921077|1110012d08rik|RIKEN cDNA 1110012D08 gene [Source:MGI Symbol;Acc:MGI:1921077]|Heterozygous||A|C|49|35.0|Non-synonymous|Unprocessed|APF-G1
1772153|IGL00801|X|104295978|I->V||0.01|Benign|0.12|tolerated|MGI:109533|Abcb7|ATP-binding cassette, sub-family B (MDR/TAP), member 7 [Source:MGI Symbol;Acc:MGI:109533]|Heterozygous|Hemizygous male and heterozygous female mice carrying a maternally inherited null allele display prenatal lethality.|T|C|48|39.0|Non-synonymous|Unprocessed|APF-G1
1772154|IGL00801|3|87813808|L->F||0.47|Possibly damaging|0.04|deleterious|MGI:1346037|Insrr|insulin receptor-related receptor [Source:MGI Symbol;Acc:MGI:1346037]|Heterozygous|Mice homozygous for a targeted null mutation exhibit no anomalies in pancreatic islet morphology, beta-cell mass or pancreatic secretory function.  This mutation in combination with Insr mutant mice does not affect the diabetes predisposition of Insr mutant mice.|C|T|46|39.5|Non-synonymous|Unprocessed|APF-G1
1772156|IGL00801|2|118122973|D->G||1.0|Probably damaging||deleterious|MGI:98737|Thbs1|thrombospondin 1 [Source:MGI Symbol;Acc:MGI:98737]|Heterozygous||A|G|31|40.0|Non-synonymous|Unprocessed|APF-G1
1772157|IGL00801|11|83855924|A->V||1.0|Probably damaging||deleterious|MGI:98505|Hnf1b|HNF1 homeobox B [Source:MGI Symbol;Acc:MGI:98505]|Heterozygous|Homozygotes for targeted null mutations exhibit reduced size, impaired development of extraembryonic membranes, lack of visceral or parietal endoderm, and early post-implantation lethality.|C|T|29|37.0|Non-synonymous|Unprocessed|APF-G1
1772158|IGL00801|1|14891333|M->T||0.24|Benign||deleterious|MGI:3522699|Trpa1|transient receptor potential cation channel, subfamily A, member 1 [Source:MGI Symbol;Acc:MGI:3522699]|Heterozygous||A|G|27|37.0|Non-synonymous|Unprocessed|APF-G1
1772159|IGL00801|19|37986073|I->T||0.99|Probably damaging||deleterious|MGI:1919192|Myof|myoferlin [Source:MGI Symbol;Acc:MGI:1919192]|Heterozygous||A|G|27|37.0|Non-synonymous|Unprocessed|APF-G1
1772160|IGL00801|15|101473860|H->Y|||Benign|0.11|tolerated|MGI:109362|Krt86|keratin 86 [Source:MGI Symbol;Acc:MGI:109362]|Heterozygous||C|T|26|35.0|Non-synonymous|Unprocessed|APF-G1
1772162|IGL00801|15|6644824|K->R||1.0|Probably damaging|0.02|deleterious|MGI:1346327|Fyb|FYN binding protein [Source:MGI Symbol;Acc:MGI:1346327]|Heterozygous|Mice homozygous for a null allele exhibit decreased T cell proliferation, thymocytes and platelet counts and decreased TCR-stimulated leukocyte adhesion.|A|G|23|35.0|Non-synonymous|Unprocessed|APF-G1
1772163|IGL00801|14|57124041|N->K||0.19|Benign|0.45|tolerated|MGI:107588|Gjb6|gap junction protein, beta 6 [Source:MGI Symbol;Acc:MGI:107588]|Heterozygous|Mice homozygous for this targeted mutation are viable and fertile but display progressive hearing loss, characterized by severe degeneration of the auditory hair cells and loss of the endocochlear potential.|A|T|16|39.5|Non-synonymous|Unprocessed|APF-G1
1772164|IGL00801|13|60761248|T->I|||Benign|0.07|tolerated|MGI:1916885|Dapk1|death associated protein kinase 1 [Source:MGI Symbol;Acc:MGI:1916885]|Heterozygous|Mice homozygous for a knock-out allele show decreased sensitivity to ER stress-induced cell death and reduced tunicamycin-induced kidney damage. Mice homozygous for a gene trapped allele show decreased infarct size and neuronal death with improved neurological scores after ischemic brain injury.|C|T|12|35.0|Non-synonymous|Unprocessed|APF-G1
1772166|IGL00801|11|79428700|Disrupted splicing||||||MGI:97306|Nf1|neurofibromatosis 1 [Source:MGI Symbol;Acc:MGI:97306]|Heterozygous|Homozygous embryos die by day 14.5 with enlarged head and chest, pale liver, microphthalmia, cardiac defects and delayed organ development. Heterozygotes have elevated astrocyte number, predisposition to multiple tumor types and learning/memory deficits.|A|T|85|39.0|Splice|Unprocessed|APF-G1
1772656|IGL00802|12|75007625|M->K||0.04|Benign|0.02|deleterious|MGI:3584508|Kcnh5|potassium voltage-gated channel, subfamily H (eag-related), member 5 [Source:MGI Symbol;Acc:MGI:3584508]|Heterozygous||A|T|82|40.0|Non-synonymous|Unprocessed|APF-G1
1772657|IGL00802|6|113805515|I->L||0.02|Benign|0.07|tolerated|MGI:105368|Atp2b2|ATPase, Ca++ transporting, plasma membrane 2 [Source:MGI Symbol;Acc:MGI:105368]|Heterozygous|Homozygous mutants exhibit slower growth, balance problems, and deafness, associated with cerebellar abnormalities, an absence of otoconia, and abnormalities of the organ of Corti.  Heterozygotes exhibit appreciable age-dependent hearing loss.|T|A|56|37.0|Non-synonymous|Unprocessed|APF-G1
1772658|IGL00802|4|98424406|D->G||0.59|Possibly damaging|0.26|tolerated|MGI:1277960|Inadl|InaD-like (Drosophila) [Source:MGI Symbol;Acc:MGI:1277960]|Heterozygous||A|G|49|37.0|Non-synonymous|Unprocessed|APF-G1
1772659|IGL00802|1|150664936|N->T|||Benign|0.78|tolerated|MGI:2685047|Hmcn1|hemicentin 1 [Source:MGI Symbol;Acc:MGI:2685047]|Heterozygous||T|G|45|39.0|Non-synonymous|Unprocessed|APF-G1
1772660|IGL00802|11|121608610|E->G||0.34|Benign|0.34|tolerated|MGI:1919686|Tbcd|tubulin-specific chaperone d [Source:MGI Symbol;Acc:MGI:1919686]|Heterozygous||A|G|35|40.0|Non-synonymous|Unprocessed|APF-G1
1772661|IGL00802|18|20041797|P->S||0.02|Benign|0.34|tolerated|MGI:103221|Dsc2|desmocollin 2 [Source:MGI Symbol;Acc:MGI:103221]|Heterozygous||G|A|28|36.5|Non-synonymous|Unprocessed|APF-G1
1772662|IGL00802|11|9297717|D->G||0.81|Possibly damaging|||MGI:2388707|Abca13|ATP-binding cassette, sub-family A (ABC1), member 13 [Source:MGI Symbol;Acc:MGI:2388707]|Heterozygous||A|G|26|37.0|Non-synonymous|Unprocessed|APF-G1
1772663|IGL00802|3|100931726|L->Q|||Unknown|||MGI:1918187|Trim45|tripartite motif-containing 45 [Source:MGI Symbol;Acc:MGI:1918187]|Heterozygous||T|A|26|39.0|Non-synonymous|Unprocessed|APF-G1
1772664|IGL00802|17|34209130|M->I||0.99|Probably damaging|0.01|deleterious|MGI:98484|Tap2|transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) [Source:MGI Symbol;Acc:MGI:98484]|Heterozygous|Homozygous mutant mice have no CD8+ T cells, although their numbers of CD4+ T cells and B cells are normal.|G|A|10|34.0|Non-synonymous|Unprocessed|APF-G1
1772667|IGL00802|8|78698580|Disrupted splicing||||||MGI:1924025|Slc10a7|solute carrier family 10 (sodium/bile acid cotransporter family), member 7 [Source:MGI Symbol;Acc:MGI:1924025]|Heterozygous||T|C|16|38.0|Splice|Unprocessed|APF-G1
1773130|IGL00803|5|34122760|L->I||0.02|Benign|0.43|tolerated|MGI:2675617|Poln|DNA polymerase N [Source:MGI Symbol;Acc:MGI:2675617]|Heterozygous||G|T|50|38.5|Non-synonymous|Unprocessed|APF-G1
1773131|IGL00803|11|71013454|V->E||0.98|Probably damaging|0.26|tolerated|MGI:2151483|Derl2|Der1-like domain family, member 2 [Source:MGI Symbol;Acc:MGI:2151483]|Heterozygous|Mice homozygous for a knock-out allele exhibit partial neonatal lethality with surviving mice exhibiting male sterility, inverted rib cage, abnormal chondrocytes in the ribs, lethality during pregancy, cachexia, and premature death.|A|T|46|39.0|Non-synonymous|Unprocessed|APF-G1
1773132|IGL00803|X|78090726|M->R||0.92|Possibly damaging|0.01|deleterious|MGI:1277949|Obp1a|odorant binding protein Ia [Source:MGI Symbol;Acc:MGI:1277949]|Heterozygous||A|C|35|39.0|Non-synonymous|Unprocessed|APF-G1
1773133|IGL00803|7|29069645|Q->L||0.65|Possibly damaging|||MGI:99659|Ryr1|ryanodine receptor 1, skeletal muscle [Source:MGI Symbol;Acc:MGI:99659]|Heterozygous|Homozygotes for a targeted null mutation and a similar ENU-induced mutation are born with a rounded body shape, edema, thin and misshapened ribs, and abnormal muscle fibers. Mutants die perinatally.|T|A|22|39.0|Non-synonymous|Unprocessed|APF-G1
1773134|IGL00803|3|93470900|T->A||0.66|Possibly damaging|0.53|tolerated|MGI:1918575|Tchhl1|trichohyalin-like 1 [Source:MGI Symbol;Acc:MGI:1918575]|Heterozygous||A|G|19|39.0|Non-synonymous|Unprocessed|APF-G1
1773135|IGL00803|1|34164124|V->I||0.03|Benign|||MGI:104627|Dst|dystonin [Source:MGI Symbol;Acc:MGI:104627]|Heterozygous|Mutations in this gene produce peripheral nervous system demyelination resulting in impaired muscle function and shorter lifespan.|G|A|17|34.0|Non-synonymous|Unprocessed|APF-G1
1773136|IGL00803|16|4483220|F->L||0.96|Probably damaging|0.01|deleterious|MGI:2146620|Srl|sarcalumenin [Source:MGI Symbol;Acc:MGI:2146620]|Heterozygous|Homozygous null mice exhibit impaired calcium store functions in skeletal and cardiac muscle cells resulting in slow contraction and relaxation phases. Muscle also exhibits enhanced resistance to fatigue.|G|T|17|37.0|Non-synonymous|Unprocessed|APF-G1
1773137|IGL00803|9|3430810|S->T||0.71|Possibly damaging|0.52|tolerated|MGI:1918023|Cwf19l2|CWF19-like 2, cell cycle control (S. pombe) [Source:MGI Symbol;Acc:MGI:1918023]|Heterozygous||T|A|14|40.5|Non-synonymous|Unprocessed|APF-G1
1773138|IGL00803|X|48369552|T->K||1.0|Probably damaging|0.12|tolerated|MGI:2443910|Bcorl1|BCL6 co-repressor-like 1 [Source:MGI Symbol;Acc:MGI:2443910]|Heterozygous||C|A|12|37.0|Non-synonymous|Unprocessed|APF-G1
1773139|IGL00803|5|31088044|S->P||1.0|Probably damaging|0.01|deleterious|MGI:1345280|Slc30a3|solute carrier family 30 (zinc transporter), member 3 [Source:MGI Symbol;Acc:MGI:1345280]|Heterozygous|While zinc is absent from synaptic vesicles in homozygous null mice, inactivation of this locus does not affect brain morphology.|A|G|10|36.5|Non-synonymous|Unprocessed|APF-G1
1773141|IGL00803|5|146001443|Disrupted splicing||||||MGI:1930638|Cyp3a25|cytochrome P450, family 3, subfamily a, polypeptide 25 [Source:MGI Symbol;Acc:MGI:1930638]|Heterozygous||A|T|21|33.0|Splice|Unprocessed|APF-G1
1773142|IGL00803|4|106385526|Disrupted splicing||||||MGI:1919936|Usp24|ubiquitin specific peptidase 24 [Source:MGI Symbol;Acc:MGI:1919936]|Heterozygous||T|C|16|39.0|Splice|Unprocessed|APF-G1
1773587|IGL00805|4|94798719|N->I||1.0|Probably damaging||deleterious|MGI:98664|Tek|endothelial-specific receptor tyrosine kinase [Source:MGI Symbol;Acc:MGI:98664]|Heterozygous|Homozygous mutation of this gene results in embryonic lethality during organogenesis, impaired vascular branching in the embryo and yolk sac, abnormal cardiac development, and in some cases hemorrhages.|A|T|96|39.0|Non-synonymous|Unprocessed|APF-G1
1773588|IGL00805|17|8437165|D->E|||Benign|0.24|tolerated|MGI:98472|T|brachyury [Source:MGI Symbol;Acc:MGI:98472]|Heterozygous|Mice carrying a t haplotype and heterozygous for a dominant brachyury allele are tailless. Mice inheriting specific combinations of t haplotypes may show transmission ratio distortion, recombination suppression, male sterility, or lethality.|T|A|69|36.0|Non-synonymous|Unprocessed|APF-G1
1773589|IGL00805|3|72934199|R->I|||Benign|0.36|tolerated|MGI:97528|Sis|sucrase isomaltase (alpha-glucosidase) [Source:MGI Symbol;Acc:MGI:1917233]|Heterozygous||C|A|61|39.0|Non-synonymous|Unprocessed|APF-G1
1773590|IGL00805|5|103554729|M->K||||0.92|tolerated|MGI:103293|Ptpn13|protein tyrosine phosphatase, non-receptor type 13 [Source:MGI Symbol;Acc:MGI:103293]|Heterozygous|Mice homozygous for a null allele exhibit abnormal T-helper cell differentiation.|T|A|48|39.0|Non-synonymous|Unprocessed|APF-G1
1773591|IGL00805|9|105064106|V->E||1.0|Probably damaging||deleterious|MGI:2137204|Mrpl3|mitochondrial ribosomal protein L3 [Source:MGI Symbol;Acc:MGI:2137204]|Heterozygous||T|A|38|39.0|Non-synonymous|Unprocessed|APF-G1
1773592|IGL00805|17|80398524|V->A||0.89|Possibly damaging|0.72|tolerated|MGI:98354|Sos1|son of sevenless homolog 1 (Drosophila) [Source:MGI Symbol;Acc:MGI:98354]|Heterozygous|Homozygous null mutant embryos exhibit placental and cardiovascular defects resulting in death around mid-gestation. When heterozygous, these mutations enhance the eye defects of homozygous mutants of the epidermal growth factor receptor gene.|A|G|26|38.5|Non-synonymous|Unprocessed|APF-G1
1773593|IGL00805|11|65881695|Y->C||0.06|Benign|0.04|deleterious|MGI:1289279|Dnahc9|dynein, axonemal, heavy chain 9 [Source:MGI Symbol;Acc:MGI:1289279]|Heterozygous||T|C|24|37.5|Non-synonymous|Unprocessed|APF-G1
1773594|IGL00805|3|108816351|D->E|||Benign|0.23|tolerated|MGI:107362|Stxbp3a|syntaxin binding protein 3A [Source:MGI Symbol;Acc:MGI:107362]|Heterozygous|Homozygous null mice display embryonic or perinatal lethality with reduced embryonic growth and malformation of the intermediate zone of the cerebral cortex.|A|T|18|39.0|Non-synonymous|Unprocessed|APF-G1
1773595|IGL00805|16|13122004|V->L||0.34|Benign|0.04|deleterious|MGI:1354163|Ercc4|excision repair cross-complementing rodent repair deficiency, complementation group 4 [Source:MGI Symbol;Acc:MGI:1354163]|Heterozygous|Homozygous null mice show impaired growth and do not survive longer than several weeks of age. Cultutred cells obtained from mutant mice were shown to be hypersensitive to UV irradiation.|G|T|15|39.0|Non-synonymous|Unprocessed|APF-G1
1773596|IGL00805|2|35380410|V->E||1.0|Probably damaging||deleterious|MGI:1922104|4930402f06rik|RIKEN cDNA 4930402F06 gene [Source:MGI Symbol;Acc:MGI:1922104]|Heterozygous||A|T|13|38.0|Non-synonymous|Unprocessed|APF-G1
1773597|IGL00805|7|110809865|I->V||0.02|Benign|0.08|tolerated|MGI:1096344|Ampd3|adenosine monophosphate deaminase 3 [Source:MGI Symbol;Acc:MGI:1096344]|Heterozygous||A|G|10|35.5|Non-synonymous|Unprocessed|APF-G1
1773598|IGL00805|18|62933865|Disrupted splicing||||||MGI:3513977|Apcdd1|adenomatosis polyposis coli down-regulated 1 [Source:MGI Symbol;Acc:MGI:3513977]|Heterozygous||T|A|38|36.5|Splice|Unprocessed|APF-G1
1773599|IGL00805|16|84815166|Disrupted splicing||||||MGI:1933820|Jam2|junction adhesion molecule 2 [Source:MGI Symbol;Acc:MGI:1933820]|Heterozygous|Mice homozygous for a knock-out allele are viable, fertile and overtly normal with no detectable spermatogenesis abnormalities or defects in embryonic, neural and hematopoietic stem cell properties.|T|C|18|36.0|Splice|Unprocessed|APF-G1
1774097|IGL00806|1|140523211|Y->H||0.92|Possibly damaging|0.05|tolerated|MGI:3036273|Kcnt2|potassium channel, subfamily T, member 2 [Source:MGI Symbol;Acc:MGI:3036273]|Heterozygous||T|C|338|40.0|Non-synonymous|Unprocessed|APF-G1
1774098|IGL00806|2|39052973|L->Stop|||N/A|||MGI:1924149|Golga1|golgi autoantigen, golgin subfamily a, 1 [Source:MGI Symbol;Acc:MGI:1924149]|Heterozygous||A|T|316|38.0|Non-synonymous|Unprocessed|APF-G1
1774099|IGL00806|4|94798719|N->I||1.0|Probably damaging||deleterious|MGI:98664|Tek|endothelial-specific receptor tyrosine kinase [Source:MGI Symbol;Acc:MGI:98664]|Heterozygous|Homozygous mutation of this gene results in embryonic lethality during organogenesis, impaired vascular branching in the embryo and yolk sac, abnormal cardiac development, and in some cases hemorrhages.|A|T|174|39.0|Non-synonymous|Unprocessed|APF-G1
1774100|IGL00806|8|43521342|Y->D||1.0|Probably damaging||deleterious|MGI:3588304|Adam26b|a disintegrin and metallopeptidase domain 26B [Source:MGI Symbol;Acc:MGI:3588304]|Heterozygous||A|C|146|39.0|Non-synonymous|Unprocessed|APF-G1
1774101|IGL00806|5|63937814|E->G||1.0|Probably damaging|0.38|tolerated|MGI:2140767|Rell1|RELT-like 1 [Source:MGI Symbol;Acc:MGI:2140767]|Heterozygous||T|C|135|37.0|Non-synonymous|Unprocessed|APF-G1
1774102|IGL00806|14|75963008|T->S||0.53|Possibly damaging|0.66|tolerated|MGI:1915955, MGI:1914766|Gtf2f2,kctd4|general transcription factor IIF, polypeptide 2 [Source:MGI Symbol;Acc:MGI:1915955],potassium channel tetramerisation domain containing 4 [Source:MGI Symbol;Acc:MGI:1914766]|Heterozygous||A|T|80|35.0|Non-synonymous|Unprocessed|APF-G1
1774103|IGL00806|12|95780529|I->T||1.0|Probably damaging||deleterious|MGI:3603594|Flrt2|fibronectin leucine rich transmembrane protein 2 [Source:MGI Symbol;Acc:MGI:3603594]|Heterozygous||T|C|63|35.0|Non-synonymous|Unprocessed|APF-G1
1774104|IGL00806|9|66089585|Y->Stop|||N/A|||MGI:1928395|Snx1|sorting nexin 1 [Source:MGI Symbol;Acc:MGI:1928395]|Heterozygous|Homozygous mutant mice are viable and fertile and do not exhibit any apparent abnormalities.|A|T|37|39.0|Non-synonymous|Unprocessed|APF-G1
1774105|IGL00806|17|74611529|V->D||0.56|Possibly damaging|0.26|tolerated|MGI:1276108|Birc6|baculoviral IAP repeat-containing 6 [Source:MGI Symbol;Acc:MGI:1276108]|Heterozygous|Homozygous mice exhibit perinatal lethality and exhibit placental defects.|T|A|33|37.0|Non-synonymous|Unprocessed|APF-G1
1774106|IGL00806|2|12255966|Q->Stop|||N/A|||MGI:109442|Itga8|integrin alpha 8 [Source:MGI Symbol;Acc:MGI:109442]|Heterozygous|Mice homozygous for disruptions in this gene usually die by the end of the second day after birth.  Those that do survive have reduced kidneys and abnormal steriocilia in the inner ear.|G|A|31|39.0|Non-synonymous|Unprocessed|APF-G1
1774107|IGL00806|8|66885800|Q->R||0.88|Possibly damaging|0.03|deleterious|MGI:2682306|Naf1|nuclear assembly factor 1 homolog (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:2682306]|Heterozygous||A|G|31|37.0|Non-synonymous|Unprocessed|APF-G1
1774108|IGL00806|2|118441166|E->G|||Benign|0.35|tolerated|MGI:1353427|Eif2ak4|eukaryotic translation initiation factor 2 alpha kinase 4 [Source:MGI Symbol;Acc:MGI:1353427]|Heterozygous|Mice homozygous for an ENU-induced allele exhibit increased susceptibility to macrophage infection with Ad5-F16-GFP and MCMV.|A|G|28|38.0|Non-synonymous|Unprocessed|APF-G1
1774109|IGL00806|9|98570664|C->R||0.86|Possibly damaging|0.33|tolerated|MGI:1354962|Copb2|coatomer protein complex, subunit beta 2 (beta prime) [Source:MGI Symbol;Acc:MGI:1354962]|Heterozygous||T|C|28|34.5|Non-synonymous|Unprocessed|APF-G1
1774110|IGL00806|15|37931622|D->N|||Benign|0.18|tolerated|MGI:2155865|Rrm2b|ribonucleotide reductase M2 B (TP53 inducible) [Source:MGI Symbol;Acc:MGI:2155865]|Heterozygous|Loss of both functional copies of this gene results in growth retardation, multiple organ failure, and ultimately premature death due to kidney failure. Spontaneous mutation rates and apoptosis are increased in the kidneys due to an attenuation of dNTP pools and a resulting impairment of DNA repair.|C|T|27|40.0|Non-synonymous|Unprocessed|APF-G1
1774111|IGL00806|8|68902366|S->P|||Benign|0.33|tolerated|MGI:96820|Lpl|lipoprotein lipase [Source:MGI Symbol;Acc:MGI:96820]|Heterozygous|Homozygotes for targeted null mutations become cyanotic and die within 2 days of birth due to chylomicron engorgement of capillaries. Mutants show hypertriglyceridemia and reduced fat stores. Heterozygotes show 1.5-2-fold elevated triglyceride levels.|T|C|26|39.0|Non-synonymous|Unprocessed|APF-G1
1774112|IGL00806|9|6288667|D->G|||Benign|0.62|tolerated|MGI:1919035|Pdgfd|platelet-derived growth factor, D polypeptide [Source:MGI Symbol;Acc:MGI:1919035]|Heterozygous||A|G|21|39.0|Non-synonymous|Unprocessed|APF-G1
1774113|IGL00806|2|29127026|Y->C||1.0|Probably damaging||deleterious|MGI:2443480|Setx|senataxin [Source:MGI Symbol;Acc:MGI:2443480]|Heterozygous||A|G|11|31.0|Non-synonymous|Unprocessed|APF-G1
1774604|IGL00807|11|80226102|H->Y||0.03|Benign|0.03|deleterious|MGI:1926078|Rhot1|ras homolog gene family, member T1 [Source:MGI Symbol;Acc:MGI:1926078]|Heterozygous||C|T|331|40.0|Non-synonymous|Unprocessed|APF-G1
1774605|IGL00807|4|94798719|N->I||1.0|Probably damaging||deleterious|MGI:98664|Tek|endothelial-specific receptor tyrosine kinase [Source:MGI Symbol;Acc:MGI:98664]|Heterozygous|Homozygous mutation of this gene results in embryonic lethality during organogenesis, impaired vascular branching in the embryo and yolk sac, abnormal cardiac development, and in some cases hemorrhages.|A|T|115|39.0|Non-synonymous|Unprocessed|APF-G1
1774606|IGL00807|2|75679413|D->G||1.0|Probably damaging||deleterious|MGI:108420|Nfe2l2|nuclear factor, erythroid derived 2, like 2 [Source:MGI Symbol;Acc:MGI:108420]|Heterozygous|Mice homozygous for a knock-out allele exhibit increased sensitivity to oxidative stress in a variety of organs and cells including brain, liver, erythrocytes, and spleen, abnormal tooth enamel, and abnormal response to various injuries, chemical treatments, and induced inflammatory diseases.|T|C|88|38.0|Non-synonymous|Unprocessed|APF-G1
1774607|IGL00807|19|9008522|V->E||0.83|Possibly damaging||deleterious|MGI:1316648|Ahnak|AHNAK nucleoprotein (desmoyokin) [Source:MGI Symbol;Acc:MGI:1316648]|Heterozygous|Mice homozygous for one knock-out allele exhibit decreaed T cell proliferation and increased susceptibility to parasitic infection.|T|A|72|38.0|Non-synonymous|Unprocessed|APF-G1
1774608|IGL00807|18|60245411|S->F||1.0|Probably damaging||deleterious|MGI:3644953|Gm4951|predicted gene 4951 [Source:MGI Symbol;Acc:MGI:3644953]|Heterozygous||C|T|64|39.0|Non-synonymous|Unprocessed|APF-G1
1774609|IGL00807|11|86233135|N->S||0.2|Benign|0.08|tolerated|MGI:1917672|Ints2|integrator complex subunit 2 [Source:MGI Symbol;Acc:MGI:1917672]|Heterozygous||T|C|37|33.0|Non-synonymous|Unprocessed|APF-G1
1774610|IGL00807|4|116705921|V->E||0.57|Possibly damaging||deleterious|MGI:1914346|Mmachc|methylmalonic aciduria cblC type, with homocystinuria [Source:MGI Symbol;Acc:MGI:1914346]|Heterozygous||A|T|36|36.5|Non-synonymous|Unprocessed|APF-G1
1774611|IGL00807|11|57012040|Y->H|||Benign|0.34|tolerated|MGI:95808|Gria1|glutamate receptor, ionotropic, AMPA1 (alpha 1) [Source:MGI Symbol;Acc:MGI:95808]|Heterozygous|Mice with mutations in phosphorylation sites have LTD and LTP deficits and spatial learning memory defects. Null homozygotes also show stimulus-reward learning deficits and increases locomotor activity and context-dependent sensitization to amphetamine.|T|C|33|36.0|Non-synonymous|Unprocessed|APF-G1
1774612|IGL00807|10|21395430|I->F||0.03|Benign|0.07|tolerated|MGI:2653900|Aldh8a1|aldehyde dehydrogenase 8 family, member A1 [Source:MGI Symbol;Acc:MGI:2653900]|Heterozygous||A|T|28|33.0|Non-synonymous|Unprocessed|APF-G1
1774613|IGL00807|1|180141453|I->V|||Benign|0.03|deleterious|MGI:2441841|Cdc42bpa|CDC42 binding protein kinase alpha [Source:MGI Symbol;Acc:MGI:2441841]|Heterozygous||A|G|26|38.0|Non-synonymous|Unprocessed|APF-G1
1774614|IGL00807|8|36572848|T->I|||Benign|0.03|deleterious|MGI:1354949|Dlc1|deleted in liver cancer 1 [Source:MGI Symbol;Acc:MGI:1354949]|Heterozygous|Homozygous mutants die by E10.5 with variable defects in the neural tube, heart, brain and placenta.|G|A|24|37.0|Non-synonymous|Unprocessed|APF-G1
1774615|IGL00807|13|13650423|M->K|||||deleterious|MGI:107448|Lyst|lysosomal trafficking regulator [Source:MGI Symbol;Acc:MGI:107448]|Heterozygous|Homozygous mice have a phenotype similar to human Chediak-Higashi syndrome patients, exhibiting lysosomal dysfunction with resultant protein storage; diluted coat color; abnormal melanogenesis; immune cell dysfunction resulting in increased susceptibility to bacterial, viral, and parasitic infections and decreased cytotoxic activity against tumor cells.|T|A|21|37.0|Non-synonymous|Unprocessed|APF-G1
1774616|IGL00807|7|101504412|V->M||1.0|Probably damaging|0.01|deleterious|MGI:2446107|Pde2a|phosphodiesterase 2A, cGMP-stimulated [Source:MGI Symbol;Acc:MGI:2446107]|Heterozygous|Mice homozygous for a knock-out allele exhibit lethality between E17 and E18.|G|A|20|39.0|Non-synonymous|Unprocessed|APF-G1
1774617|IGL00807|9|123977469|W->R|||Benign|0.35|tolerated|MGI:104617|Ccr1l1|chemokine (C-C motif) receptor 1-like 1 [Source:MGI Symbol;Acc:MGI:104617]|Heterozygous|Mice homozygous for a targeted null mutation do not exhibit any significant abnormalities compared to controls.|A|T|17|37.0|Non-synonymous|Unprocessed|APF-G1
1774618|IGL00807|11|9378285|T->S|||Benign|||MGI:2388707|Abca13|ATP-binding cassette, sub-family A (ABC1), member 13 [Source:MGI Symbol;Acc:MGI:2388707]|Heterozygous||A|T|15|35.0|Non-synonymous|Unprocessed|APF-G1
1774619|IGL00807|10|23940675|M->V||0.06|Benign|0.02|deleterious|MGI:2685071|Taar2|trace amine-associated receptor 2 [Source:MGI Symbol;Acc:MGI:2685071]|Heterozygous||A|G|10|37.0|Non-synonymous|Unprocessed|APF-G1
1774620|IGL00807|17|36964921|A->S||||0.33|tolerated|MGI:1923666|Znrd1as|ZNRD1 antisense RNA [Source:MGI Symbol;Acc:MGI:1923666]|Heterozygous||G|T|10|38.0|Non-synonymous|Unprocessed|APF-G1
1774622|IGL00807|1|127797891|Disrupted splicing||||||MGI:1920199|Ccnt2|cyclin T2 [Source:MGI Symbol;Acc:MGI:1920199]|Heterozygous|Mice homozygous for a gene trap allele die prior to the 4-cell stage.|T|C|52|37.0|Splice|Unprocessed|APF-G1
1774623|IGL00807|8|68329366|Disrupted splicing||||||MGI:1919531|Sh2d4a|SH2 domain containing 4A [Source:MGI Symbol;Acc:MGI:1919531]|Heterozygous|Mice homozygous for a knock-out allele display normal T cell development, homeostasis, proliferation, and function.|T|C|21|37.0|Splice|Unprocessed|APF-G1
1774624|IGL00807|10|117074886|Disrupted splicing||||||MGI:1100860|Frs2|fibroblast growth factor receptor substrate 2 [Source:MGI Symbol;Acc:MGI:1100860]|Heterozygous|Homozygous null mice exhibit embryonic lethality between E5.75 and E8 and defects in primitive streak formation and anterior-posterior axis formation.|A|C|12|37.0|Splice|Unprocessed|APF-G1
1775059|IGL00808|1|139461476|S->T|||Benign|0.07|tolerated|MGI:1334448|Aspm|asp (abnormal spindle)-like, microcephaly associated (Drosophila) [Source:MGI Symbol;Acc:MGI:1334448]|Heterozygous||T|A|210|37.0|Non-synonymous|Unprocessed|APF-G1
1775060|IGL00808|17|65983965|L->S||||0.05|deleterious|MGI:1914357|Ankrd12|ankyrin repeat domain 12 [Source:MGI Symbol;Acc:MGI:1914357]|Heterozygous||A|G|52|37.0|Non-synonymous|Unprocessed|APF-G1
1775061|IGL00808|7|97716514|H->R||1.0|Probably damaging||deleterious|MGI:109638|Clns1a|chloride channel, nucleotide-sensitive, 1A [Source:MGI Symbol;Acc:MGI:109638]|Heterozygous|Homozygous mutants die between E3.5-E7.5. Heterozygous mutants appear normal and healthy.|A|G|41|37.0|Non-synonymous|Unprocessed|APF-G1
1775062|IGL00808|15|65995754|D->G||0.42|Benign|0.36|tolerated|MGI:1336181|Kcnq3|potassium voltage-gated channel, subfamily Q, member 3 [Source:MGI Symbol;Acc:MGI:1336181]|Heterozygous|Mice homozygous for a null allele exhibit abnormal apamin-insensitive afterhyperpolarization currents in granule cells, but not pyramidal cells, of the hippocampus.  Mice homozygous for a knock-in allele exhibit spontaneous seizures and premature death.|T|C|33|37.0|Non-synonymous|Unprocessed|APF-G1
1775063|IGL00808|7|80259549|A->S||0.24|Benign|0.01|deleterious|MGI:1920845|Ttll13|tubulin tyrosine ligase-like family, member 13 [Source:MGI Symbol;Acc:MGI:1920845]|Heterozygous||G|T|33|37.0|Non-synonymous|Unprocessed|APF-G1
1775064|IGL00808|5|84106700|V->E||0.98|Probably damaging||deleterious|MGI:99654|Epha5|Eph receptor A5 [Source:MGI Symbol;Acc:MGI:99654]|Heterozygous|Homozygous mutant mice are overtly normal but show abnormal retinal axon mapping.|A|T|32|38.0|Non-synonymous|Unprocessed|APF-G1
1775065|IGL00808|6|118088203|K->M||0.56|Possibly damaging|0.03|deleterious|MGI:1917977|Rasgef1a|RasGEF domain family, member 1A [Source:MGI Symbol;Acc:MGI:1917977]|Heterozygous||A|T|30|35.0|Non-synonymous|Unprocessed|APF-G1
1775066|IGL00808|7|28614952|I->T||1.0|Probably damaging|0.01|deleterious|MGI:2142121|C330005m16rik|RIKEN cDNA C330005M16 gene [Source:MGI Symbol;Acc:MGI:2142121]|Heterozygous||A|G|19|37.0|Non-synonymous|Unprocessed|APF-G1
1775067|IGL00808|13|59462094|E->G||0.89|Possibly damaging|0.05|tolerated|MGI:2159437|Agtpbp1|ATP/GTP binding protein 1 [Source:MGI Symbol;Acc:MGI:2159437]|Heterozygous|Homozygotes show moderate ataxia due to degeneration of Purkinje cells of the cerebellum. Also, there is gradual degeneration of retina photoreceptor cells, olfactory bulb mitral cells and some thalamic neurons. Males have abnormal sperm and are sterile.|T|C|18|36.5|Non-synonymous|Unprocessed|APF-G1
1775068|IGL00808|15|66683813|Y->N||1.0|Probably damaging||deleterious|MGI:98733|Tg|thyroglobulin [Source:MGI Symbol;Acc:MGI:98733]|Heterozygous|Mice homozygous for a spontaneous mutation exhibit enlarged thyroid gland, hypothyroidism, abnormal thyroid gland morphology, and decreased body weight.|T|A|17|37.0|Non-synonymous|Unprocessed|APF-G1
1775069|IGL00808|1|157470676|F->L|||Benign|0.36|tolerated|MGI:2448516|Bc026585|cDNA sequence BC026585 [Source:MGI Symbol;Acc:MGI:2448516]|Heterozygous||T|C|15|36.0|Non-synonymous|Unprocessed|APF-G1
1775070|IGL00808|7|28290426|S->P||||0.45|tolerated|MGI:3608324|Bc089491|cDNA sequence BC089491 [Source:MGI Symbol;Acc:MGI:3608324]|Heterozygous||A|G|14|36.0|Non-synonymous|Unprocessed|APF-G1
1775071|IGL00808|7|29198146|S->P||0.95|Possibly damaging|0.27|tolerated|MGI:2443617|Catsperg1|cation channel, sperm-associated, gamma 1 [Source:MGI Symbol;Acc:MGI:2443617]|Heterozygous||A|G|13|39.0|Non-synonymous|Unprocessed|APF-G1
1775072|IGL00808|6|145246748|T->A||1.0|Probably damaging|0.02|deleterious|MGI:96680|Kras|v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog [Source:MGI Symbol;Acc:MGI:96680]|Heterozygous|Mice homozygous for a null allele exhibit embryonic lethality, decreased fetal growth, pericardial edema, anemia, and liver hypoplasia.  Mice heterozygous for various knock-in alleles exhibit increased tumorigenesis.|T|C|12|37.5|Non-synonymous|Unprocessed|APF-G1
1775073|IGL00808|7|81283014|Disrupted splicing||||||MGI:1277116|Pde8a|phosphodiesterase 8A [Source:MGI Symbol;Acc:MGI:1277116]|Heterozygous|Targeted disruption of this gene results in a 4-fold increase in basal release of testosterone in isolated Leydig cells as well as a significant increase in the sensitivity to luteinizing hormone, measured as testosterone released into the media.|G|A|56|38.0|Splice|Unprocessed|APF-G1
1775074|IGL00808|11|67335004|Disrupted splicing||||||MGI:1339967|Myh13|myosin, heavy polypeptide 13, skeletal muscle [Source:MGI Symbol;Acc:MGI:1339967]|Heterozygous||T|C|51|37.0|Splice|Unprocessed|APF-G1
1775075|IGL00808|13|14136261|Disrupted splicing||||||MGI:2137512|Arid4b|AT rich interactive domain 4B (RBP1-like) [Source:MGI Symbol;Acc:MGI:2137512]|Heterozygous|Mice homozygous for a null allele die pre-implantation.|T|C|23|39.0|Splice|Unprocessed|APF-G1
1775077|IGL00808|12|13566120|Disrupted splicing||||||MGI:1918419|Nbas|neuroblastoma amplified sequence [Source:MGI Symbol;Acc:MGI:1918419]|Heterozygous||T|C|13|35.0|Splice|Unprocessed|APF-G1
1775579|IGL00809|12|85049194|I->T||0.98|Probably damaging||deleterious|MGI:1926195|Ylpm1|YLP motif containing 1 [Source:MGI Symbol;Acc:MGI:1926195]|Heterozygous||T|C|357|39.0|Non-synonymous|Unprocessed|APF-G1
1775580|IGL00809|1|130452511|Y->Stop|||N/A|||MGI:104850|Cd55|CD55 antigen [Source:MGI Symbol;Acc:MGI:104850]|Heterozygous|Homozygous mutant mice show increased susceptibility to injury following ethanol exposure, to experimental autoimmune myasthenia gravis and to acute nephrotoxic nephritis. Another allele results in an abnormal complement cascade leading to increased C3 deposition.|A|T|238|38.0|Non-synonymous|Unprocessed|APF-G1
1775581|IGL00809|14|87000027|H->Q||0.03|Benign|0.63|tolerated|MGI:1927222|Diap3|diaphanous homolog 3 (Drosophila) [Source:MGI Symbol;Acc:MGI:1927222]|Heterozygous||A|T|138|38.0|Non-synonymous|Unprocessed|APF-G1
1775582|IGL00809|9|82871303|S->F||||0.02|deleterious|MGI:1932404|Phip|pleckstrin homology domain interacting protein [Source:MGI Symbol;Acc:MGI:1932404]|Heterozygous|Mice homozygous for a gene trapped allele exhibit postnatal and premature lethality associated with reduced body size, small myocardial cells and hepatocytes, hypoglycemia, increased insulin sensitivity, and reduced cell growth.|G|A|138|37.0|Non-synonymous|Unprocessed|APF-G1
1775583|IGL00809|4|103235786|T->A||0.57|Possibly damaging|0.08|tolerated|MGI:1918191|4921539e11rik|RIKEN cDNA 4921539E11 gene [Source:MGI Symbol;Acc:MGI:1918191]|Heterozygous||T|C|122|38.0|Non-synonymous|Unprocessed|APF-G1
1775584|IGL00809|11|61915071|N->I||0.93|Possibly damaging|0.37|tolerated|MGI:1890218|Akap10|A kinase (PRKA) anchor protein 10 [Source:MGI Symbol;Acc:MGI:1890218]|Heterozygous|Mice homozygous for a gene trapped allele display sinus arrhythmia, sinus pauses, and atrioventricular heart block indicating excessive vagus nerve sensitivity; about 50% of homozygous and 25% of heterozygous mutant mice die in the first year of life, and survival is sensitive to genetic background.|T|A|90|37.5|Non-synonymous|Unprocessed|APF-G1
1775585|IGL00809|1|169965755|Y->Stop|||N/A|||MGI:1330808|Hsd17b7|hydroxysteroid (17-beta) dehydrogenase 7 [Source:MGI Symbol;Acc:MGI:1330808]|Heterozygous|Mice homozygous for a targeted allele exhibit embryonic lethality, abnormal brain development, abnormal branchial arches, pericardial effusion, and abnormal cardiovascular development.|A|T|77|38.0|Non-synonymous|Unprocessed|APF-G1
1775586|IGL00809|13|114877625|A->S||0.96|Probably damaging|0.01|deleterious|MGI:96600|Itga2|integrin alpha 2 [Source:MGI Symbol;Acc:MGI:96600]|Heterozygous|Homozygotes for targeted null mutations were viable, fertile, showed no overt anatomical defects, and exhibited no bleeding anomalies.  Platelet, primary fibroblast and keratinocytes from homozygous mutant mice show less efficient adhesion to collagens in vitro.|C|A|68|38.0|Non-synonymous|Unprocessed|APF-G1
1775587|IGL00809|14|31014189|I->T||0.28|Benign|0.01|deleterious|MGI:1353651|Gnl3|guanine nucleotide binding protein-like 3 (nucleolar) [Source:MGI Symbol;Acc:MGI:1353651]|Heterozygous|Homozygous disruption of this gene leads to early embryonic loss as blastocysts fail to enter the S phase. MEFs heterozygous for a gene trap allele have reduced proliferative capacity while MEFs heterozygous for a null allele show reduced doubling rates, increased apoptosis and premature senescence.|A|G|61|37.0|Non-synonymous|Unprocessed|APF-G1
1775588|IGL00809|6|51467013|G->S||0.93|Possibly damaging||deleterious|MGI:104819|Hnrnpa2b1|heterogeneous nuclear ribonucleoprotein A2/B1 [Source:MGI Symbol;Acc:MGI:104819]|Heterozygous||C|T|50|38.0|Non-synonymous|Unprocessed|APF-G1
1775589|IGL00809|2|120760269|D->V||1.0|Probably damaging|0.01|deleterious|MGI:2155779|Ttbk2|tau tubulin kinase 2 [Source:MGI Symbol;Acc:MGI:2155779]|Heterozygous|Mice homozygous for a knock-in allele exhibit complete preweaning lethality, decreased embryo size, growth retardation, and incomplete turning.|T|A|46|37.0|Non-synonymous|Unprocessed|APF-G1
1775590|IGL00809|14|31300809|Q->Stop|||N/A|||MGI:107721|Dnahc1|dynein, axonemal, heavy chain 1 [Source:MGI Symbol;Acc:MGI:107721]|Heterozygous|Homozygous mutants are male sterile, and show impaired ciliary and flagellar motility that is also observed in the tracheal cilia.|G|A|45|37.0|Non-synonymous|Unprocessed|APF-G1
1775591|IGL00809|11|116859351|S->T||0.85|Possibly damaging||deleterious|MGI:1917150|Mfsd11|major facilitator superfamily domain containing 11 [Source:MGI Symbol;Acc:MGI:1917150]|Heterozygous||T|A|36|37.0|Non-synonymous|Unprocessed|APF-G1
1775592|IGL00809|2|66483935|I->N||0.97|Probably damaging||deleterious|MGI:107636|Scn9a|sodium channel, voltage-gated, type IX, alpha [Source:MGI Symbol;Acc:MGI:107636]|Heterozygous|Mice homozygous for a knock-out allele exhibit prenatal/neonatal lethality.  Mice homozygous for a knock-in allele exhibit increased susceptibility to electrically induced seizures.|A|T|35|38.0|Non-synonymous|Unprocessed|APF-G1
1775593|IGL00809|4|109133763|R->H||1.0|Probably damaging||deleterious|MGI:1923784|Osbpl9|oxysterol binding protein-like 9 [Source:MGI Symbol;Acc:MGI:1923784]|Heterozygous||C|T|35|33.0|Non-synonymous|Unprocessed|APF-G1
1775594|IGL00809|3|92572512|Q->L||0.05|Benign|0.01|deleterious|MGI:96626|Ivl|involucrin [Source:MGI Symbol;Acc:MGI:96626]|Heterozygous|Mice homozygous for disruptions in this gene display a normal phenotype.|T|A|33|37.0|Non-synonymous|Unprocessed|APF-G1
1775595|IGL00809|11|54649300|Q->K||0.99|Probably damaging|0.14|tolerated|MGI:2384761|Rapgef6|Rap guanine nucleotide exchange factor (GEF) 6 [Source:MGI Symbol;Acc:MGI:2384761]|Heterozygous|Mice homozygous for a null allele exhibit an inlarged spleen, increased IgE and IgG levels and altered cytokine production.|C|A|30|38.0|Non-synonymous|Unprocessed|APF-G1
1775596|IGL00809|9|98992165|G->R||1.0|Probably damaging|0.15|tolerated|MGI:1344387|Faim|Fas apoptotic inhibitory molecule [Source:MGI Symbol;Acc:MGI:1344387]|Heterozygous|Mice homozygous for a null allele have thymocytes with an enhanced susceptibility to FAS-induced apoptosis, and B cells that more susceptible to activation induced cell death.|G|A|28|37.0|Non-synonymous|Unprocessed|APF-G1
1775597|IGL00809|9|103453098|E->G||1.0|Probably damaging|0.01|deleterious|MGI:1333828|Bfsp2|beaded filament structural protein 2, phakinin [Source:MGI Symbol;Acc:MGI:1333828]|Heterozygous|Mutations at this locus result in eye abnormalities.|T|C|28|35.0|Non-synonymous|Unprocessed|APF-G1
1775598|IGL00809|5|47989151|E->K||1.0|Probably damaging|0.03|deleterious|MGI:1315205|Slit2|slit homolog 2 (Drosophila) [Source:MGI Symbol;Acc:MGI:1315205]|Heterozygous|Homozygous mutants display perinatal lethality, abnormal ureteric bud development, multiple fused kidneys, multiple ureters, and hydroureter.|G|A|27|38.0|Non-synonymous|Unprocessed|APF-G1
1775599|IGL00809|19|47681403|H->Q||1.0|Probably damaging|0.18|tolerated|MGI:88450|Col17a1|collagen, type XVII, alpha 1 [Source:MGI Symbol;Acc:MGI:88450]|Heterozygous|Mice homozygous for a knock-out allele are unable to reproduce and display postnatal growth retardation, blisters and erosion at sites of trauma, nonpigmented hair growth associated with hair loss, subepidermal blistering associated with poorly formed hemidesmosomes, and high postnatal lethality.|G|T|22|35.0|Non-synonymous|Unprocessed|APF-G1
1775600|IGL00809|5|14675797|D->E|||Benign|||MGI:1349390|Pclo|piccolo (presynaptic cytomatrix protein) [Source:MGI Symbol;Acc:MGI:1349390]|Heterozygous|Mice homozygous for one deletion of Pclo are viable and fertile, and display no overt abnormal phenotype. Mice homozygous for another knock-out allele exhibit some premature lethality, decreased body size, and abnormal synaptic vesicle number.|T|A|22|36.5|Non-synonymous|Unprocessed|APF-G1
1775601|IGL00809|4|134008056|G->S||0.99|Probably damaging|0.01|deleterious|MGI:1890546|Lin28a|lin-28 homolog A (C. elegans) [Source:MGI Symbol;Acc:MGI:1890546]|Heterozygous|Mice homozygous for a knock-out allele exhibit decreased birth weight and postnatal lethality.|C|T|21|37.0|Non-synonymous|Unprocessed|APF-G1
1775602|IGL00809|10|81370525|S->Stop|||N/A|||MGI:1926790|Fzr1|fizzy/cell division cycle 20 related 1 (Drosophila) [Source:MGI Symbol;Acc:MGI:1926790]|Heterozygous|Homozygous null mutants die embryonically at around E9.5-E12.5 with poorly developed placentae, no placental giant cells and/or erythroblast deficiency. Homozygous MEFs undergo premature senescence. Heterozygotes exhibit learning/memory defects and/or elevatedspontaneous epithelial tumor incidence.|G|T|20|36.0|Non-synonymous|Unprocessed|APF-G1
1775603|IGL00809|2|181697334|S->T||0.39|Benign|0.65|tolerated|MGI:2685538|4930526d03rik|RIKEN cDNA 4930526D03 gene [Source:MGI Symbol;Acc:MGI:2685538]|Heterozygous||A|T|19|35.0|Non-synonymous|Unprocessed|APF-G1
1775604|IGL00809|13|56822488|I->V|||Benign|1.0|tolerated|MGI:1349470|Trpc7|transient receptor potential cation channel, subfamily C, member 7 [Source:MGI Symbol;Acc:MGI:1349470]|Heterozygous||T|C|18|39.0|Non-synonymous|Unprocessed|APF-G1
1775605|IGL00809|6|50196589|R->C||0.03|Benign|0.05|deleterious|MGI:1927340|Mpp6|membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6) [Source:MGI Symbol;Acc:MGI:1927340]|Heterozygous||C|T|17|37.0|Non-synonymous|Unprocessed|APF-G1
1775606|IGL00809|3|103988667|S->P|||Benign|0.22|tolerated|MGI:1332671|Phtf1|putative homeodomain transcription factor 1 [Source:MGI Symbol;Acc:MGI:1332671]|Heterozygous||T|C|16|39.5|Non-synonymous|Unprocessed|APF-G1
1775607|IGL00809|10|81643067|D->V|||Unknown|0.11|tolerated|MGI:1890394|Ankrd24|ankyrin repeat domain 24 [Source:MGI Symbol;Acc:MGI:1890394]|Heterozygous||A|T|11|36.0|Non-synonymous|Unprocessed|APF-G1
1775609|IGL00809|10|86848174|Disrupted splicing||||||MGI:2178743|Stab2|stabilin 2 [Source:MGI Symbol;Acc:MGI:2178743]|Heterozygous|Mice homozygous for a knock-out allele exhibit no physical or behavioral abnormalities.|A|T|23|37.0|Splice|Unprocessed|APF-G1
1775610|IGL00809|10|128939169|Disrupted splicing||||||MGI:102700|Itga7|integrin alpha 7 [Source:MGI Symbol;Acc:MGI:102700]|Heterozygous||T|C|17|32.0|Splice|Unprocessed|APF-G1
1776104|IGL00810|X|154484116|I->V||0.87|Possibly damaging|0.42|tolerated|MGI:1922435|4930542n07rik|RIKEN cDNA 4930542N07 gene [Source:MGI Symbol;Acc:MGI:1922435]|Heterozygous||A|G|107|39.0|Non-synonymous|Unprocessed|APF-G1
1776105|IGL00810|2|119069246|I->T||0.99|Probably damaging|0.28|tolerated|MGI:1923714|Casc5|cancer susceptibility candidate 5 [Source:MGI Symbol;Acc:MGI:1923714]|Heterozygous||T|C|104|39.0|Non-synonymous|Unprocessed|APF-G1
1776106|IGL00810|X|135613382|V->E||1.0|Probably damaging|0.07|tolerated|MGI:1923079|Prame|preferentially expressed antigen in melanoma [Source:MGI Symbol;Acc:MGI:1923079]|Heterozygous||A|T|57|38.0|Non-synonymous|Unprocessed|APF-G1
1776107|IGL00810|7|80502753|P->Q||0.65|Possibly damaging|0.38|tolerated|MGI:1328362|Blm|Bloom syndrome, RecQ helicase-like [Source:MGI Symbol;Acc:MGI:1328362]|Heterozygous|Homozygous null mutants are developmentally delayed, with increased apopotosis in the epiblast and severe anemia, dying at embyronic day 13.5; but homozygotes for a cre mediated recombinant allele are viable Bloom syndrome-like mice prone to a wide variety of cancers and showing increased rates of LOH.|G|T|47|39.0|Non-synonymous|Unprocessed|APF-G1
1776108|IGL00810|X|21715194|E->V||0.02|Benign|0.01|deleterious|MGI:1890216|Slc6a14|solute carrier family 6 (neurotransmitter transporter), member 14 [Source:MGI Symbol;Acc:MGI:1890216]|Heterozygous||A|T|42|35.0|Non-synonymous|Unprocessed|APF-G1
1776109|IGL00810|6|125963606|A->D||0.72|Possibly damaging|0.01|deleterious|MGI:2387214|Ano2|anoctamin 2 [Source:MGI Symbol;Acc:MGI:2387214]|Heterozygous|Mice homozygous for a knock-out allele lack calcium-activated chloride currents in the main olfactory epithelium and vomeronasal organ but normal olfaction in behavioral tasks.|C|A|38|35.0|Non-synonymous|Unprocessed|APF-G1
1776110|IGL00810|15|63859119|R->W||1.0|Probably damaging|0.01|deleterious|MGI:3580656|Gsdmc3|gasdermin C3 [Source:MGI Symbol;Acc:MGI:3580656]|Heterozygous||G|A|31|37.0|Non-synonymous|Unprocessed|APF-G1
1776111|IGL00810|9|122930103|C->R|||||deleterious|MGI:1277119|Zfp105|zinc finger protein 105 [Source:MGI Symbol;Acc:MGI:1277119]|Heterozygous||T|C|30|39.0|Non-synonymous|Unprocessed|APF-G1
1776112|IGL00810|3|34064218|N->S||0.04|Benign|0.51|tolerated|MGI:104860, MGI:1914963|Dnajc19,fxr1|DnaJ (Hsp40) homolog, subfamily C, member 19 [Source:MGI Symbol;Acc:MGI:1914963],fragile X mental retardation gene 1, autosomal homolog [Source:MGI Symbol;Acc:MGI:104860]|Heterozygous|Homozygous null mice display neonatal lethality with impaired muscle development. Mice homozygous for a hypomorphic allele display a reduced life span with impaired muscle development, growth retardation, and reduced grip strength.,NO_PHENOTYPE|A|G|28|34.0|Non-synonymous|Unprocessed|APF-G1
1776113|IGL00810|8|95718527|W->R||0.68|Possibly damaging|0.27|tolerated|MGI:1913333|Setd6|SET domain containing 6 [Source:MGI Symbol;Acc:MGI:1913333]|Heterozygous||T|A|27|34.0|Non-synonymous|Unprocessed|APF-G1
1776114|IGL00810|5|14676392|R->Stop|||N/A|||MGI:1349390|Pclo|piccolo (presynaptic cytomatrix protein) [Source:MGI Symbol;Acc:MGI:1349390]|Heterozygous|Mice homozygous for one deletion of Pclo are viable and fertile, and display no overt abnormal phenotype. Mice homozygous for another knock-out allele exhibit some premature lethality, decreased body size, and abnormal synaptic vesicle number.|A|T|25|32.0|Non-synonymous|Unprocessed|APF-G1
1776115|IGL00810|5|87465529|M->K||0.98|Probably damaging|0.01|deleterious|MGI:2149905|Ugt2a1|UDP glucuronosyltransferase 2 family, polypeptide A1 [Source:MGI Symbol;Acc:MGI:2149905]|Heterozygous||A|T|24|39.0|Non-synonymous|Unprocessed|APF-G1
1776116|IGL00810|18|37486168|V->A||1.0|Probably damaging||deleterious|MGI:2136754|Pcdhb17|protocadherin beta 17 [Source:MGI Symbol;Acc:MGI:2136754]|Heterozygous||T|C|23|33.0|Non-synonymous|Unprocessed|APF-G1
1776117|IGL00810|5|47989151|E->K||1.0|Probably damaging|0.03|deleterious|MGI:1315205|Slit2|slit homolog 2 (Drosophila) [Source:MGI Symbol;Acc:MGI:1315205]|Heterozygous|Homozygous mutants display perinatal lethality, abnormal ureteric bud development, multiple fused kidneys, multiple ureters, and hydroureter.|G|A|23|39.0|Non-synonymous|Unprocessed|APF-G1
1776118|IGL00810|9|98992165|G->R||1.0|Probably damaging|0.15|tolerated|MGI:1344387|Faim|Fas apoptotic inhibitory molecule [Source:MGI Symbol;Acc:MGI:1344387]|Heterozygous|Mice homozygous for a null allele have thymocytes with an enhanced susceptibility to FAS-induced apoptosis, and B cells that more susceptible to activation induced cell death.|G|A|23|39.0|Non-synonymous|Unprocessed|APF-G1
1776119|IGL00810|13|100539461|I->V||0.99|Probably damaging|0.32|tolerated|MGI:106183|Ocln|occludin [Source:MGI Symbol;Acc:MGI:106183]|Heterozygous|Homozygous null mice display gastritis, loss of gastric parietal and chief cells, gastric mucus cell hyperplasia, reduced gastric acid secretion, growth retardation, male infertility, seminiferous tubule atrophy, failure to nurse pups, mineral deposits in the brain, and thinning of the compact bone.|T|C|21|38.0|Non-synonymous|Unprocessed|APF-G1
1776120|IGL00810|1|71292556|M->I|||Benign|0.95|tolerated|MGI:2676312|Abca12|ATP-binding cassette, sub-family A (ABC1), member 12 [Source:MGI Symbol;Acc:MGI:2676312]|Heterozygous|Mice homozygous for a null allele exhibit neonatal lethality associated with defective skin development and abnormal lung morphology.|C|A|17|38.0|Non-synonymous|Unprocessed|APF-G1
1776121|IGL00810|16|93690342|I->L|||Benign|0.21|tolerated|MGI:1309992|Cbr3|carbonyl reductase 3 [Source:MGI Symbol;Acc:MGI:1309992]|Heterozygous||A|C|17|37.0|Non-synonymous|Unprocessed|APF-G1
1776122|IGL00810|1|58159009|A->V||0.08|Benign|0.07|tolerated|MGI:1918974|Aox3|aldehyde oxidase 3 [Source:MGI Symbol;Acc:MGI:1918974]|Heterozygous||C|T|15|38.0|Non-synonymous|Unprocessed|APF-G1
1776123|IGL00810|10|14469026|Y->C||1.0|Probably damaging||deleterious|MGI:1916151|Gpr126|G protein-coupled receptor 126 [Source:MGI Symbol;Acc:MGI:1916151]|Heterozygous|Mice homozygous for a null mutation die during organogenesis and display signs of circulatory failure.|T|C|14|37.0|Non-synonymous|Unprocessed|APF-G1
1776124|IGL00810|1|164053067|C->F||1.0|Probably damaging||deleterious|MGI:98278|Sele|selectin, endothelial cell [Source:MGI Symbol;Acc:MGI:98278]|Heterozygous|Homozygotes for targeted null mutations exhibit mild defects in neutrophil infiltration during inflammatory responses. When combined with other selectin gene knockouts, more severe defects are present.|G|T|12|39.0|Non-synonymous|Unprocessed|APF-G1
1776125|IGL00810|12|87127333|Y->C||1.0|Probably damaging||deleterious|MGI:2444430|Pomt2|protein-O-mannosyltransferase 2 [Source:MGI Symbol;Acc:MGI:2444430]|Heterozygous||T|C|12|33.5|Non-synonymous|Unprocessed|APF-G1
1776128|IGL00810|3|117671892|Disrupted splicing||||||MGI:1923019|4833424o15rik|RIKEN cDNA 4833424O15 gene [Source:MGI Symbol;Acc:MGI:1923019]|Heterozygous||A|T|45|40.0|Splice|Unprocessed|APF-G1
1776130|IGL00810|X|152267888|Disrupted splicing||||||MGI:99781|Kdm5c|lysine (K)-specific demethylase 5C [Source:MGI Symbol;Acc:MGI:99781]|Heterozygous||T|A|15|38.0|Splice|Unprocessed|APF-G1
1776596|IGL00811|5|43758225|L->P||1.0|Probably damaging||deleterious|MGI:2152883|Fbxl5|F-box and leucine-rich repeat protein 5 [Source:MGI Symbol;Acc:MGI:2152883]|Heterozygous||A|G|110|39.0|Non-synonymous|Unprocessed|APF-G1
1776597|IGL00811|14|61604857|T->A||1.0|Probably damaging|0.27|tolerated|MGI:1913847|Trim13|tripartite motif-containing 13 [Source:MGI Symbol;Acc:MGI:1913847]|Heterozygous||A|G|108|39.0|Non-synonymous|Unprocessed|APF-G1
1776598|IGL00811|15|6815666|T->I||0.84|Possibly damaging|0.09|tolerated|MGI:1330819|Osmr|oncostatin M receptor [Source:MGI Symbol;Acc:MGI:1330819]|Heterozygous|Mice homozygous for a knock-out allele exhibit anemia, decreased hematocrit, and reduced erythroid progenitor, erythrocyte, platelet, and megakaryocyte cells.|G|A|107|40.0|Non-synonymous|Unprocessed|APF-G1
1776599|IGL00811|2|75925972|F->L|||Benign|0.62|tolerated|MGI:2443065|Agps|alkylglycerone phosphate synthase [Source:MGI Symbol;Acc:MGI:2443065]|Heterozygous|Mice homozygous for a spontaneous allele exhibit male infertility, azoospermia, microphthalmia, and cataracts.|T|C|100|39.0|Non-synonymous|Unprocessed|APF-G1
1776600|IGL00811|9|62796919|V->D||1.0|Probably damaging||deleterious|MGI:1335087|Fem1b|feminization 1 homolog b (C. elegans) [Source:MGI Symbol;Acc:MGI:1335087]|Heterozygous|Homozygous targeted mutants display abnormal glucose tolerance due to defective glucose-stimulated insulin secretion.|A|T|94|38.0|Non-synonymous|Unprocessed|APF-G1
1776601|IGL00811|11|49095417|F->L||0.01|Benign|0.92|tolerated|MGI:99448|Ifi47|interferon gamma inducible protein 47 [Source:MGI Symbol;Acc:MGI:99448]|Heterozygous|In the absence of infection, mice show no overt phenotype. Resistance to protozoan parasitic infection is impaired in homozygous mutant mice, whereas resistance to bacterial and viral infection are normal.|T|C|93|39.0|Non-synonymous|Unprocessed|APF-G1
1776602|IGL00811|11|77441926|A->V||1.0|Probably damaging||deleterious|MGI:2679255|Ssh2|slingshot homolog 2 (Drosophila) [Source:MGI Symbol;Acc:MGI:2679255]|Heterozygous||C|T|93|39.0|Non-synonymous|Unprocessed|APF-G1
1776603|IGL00811|5|14680010|T->A||0.88|Possibly damaging|||MGI:1349390|Pclo|piccolo (presynaptic cytomatrix protein) [Source:MGI Symbol;Acc:MGI:1349390]|Heterozygous|Mice homozygous for one deletion of Pclo are viable and fertile, and display no overt abnormal phenotype. Mice homozygous for another knock-out allele exhibit some premature lethality, decreased body size, and abnormal synaptic vesicle number.|A|G|89|39.0|Non-synonymous|Unprocessed|APF-G1
1776604|IGL00811|9|98992165|G->R||1.0|Probably damaging|0.15|tolerated|MGI:1344387|Faim|Fas apoptotic inhibitory molecule [Source:MGI Symbol;Acc:MGI:1344387]|Heterozygous|Mice homozygous for a null allele have thymocytes with an enhanced susceptibility to FAS-induced apoptosis, and B cells that more susceptible to activation induced cell death.|G|A|65|37.0|Non-synonymous|Unprocessed|APF-G1
1776605|IGL00811|9|69371290|T->K||0.24|Benign|0.32|tolerated|MGI:104661|Rora|RAR-related orphan receptor alpha [Source:MGI Symbol;Acc:MGI:104661]|Heterozygous|Homozygotes for null mutations exhibit ataxia, cerebellar dysgenesis, impaired Purkinje and granule cell development, olfactory defects, hypoalphalipoproteinemia, and death around 4 weeks. Heterozygotes show slow Purkinje cell dedritic atrophy and loss.|C|A|54|39.0|Non-synonymous|Unprocessed|APF-G1
1776606|IGL00811|2|124658469|P->Q||1.0|Probably damaging||deleterious|MGI:2387661|Sema6d|sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D [Source:MGI Symbol;Acc:MGI:2387661]|Heterozygous||C|A|49|37.0|Non-synonymous|Unprocessed|APF-G1
1776607|IGL00811|9|67948181|N->K||0.25|Benign|0.05|deleterious|MGI:2444207|Vps13c|vacuolar protein sorting 13C (yeast) [Source:MGI Symbol;Acc:MGI:2444207]|Heterozygous||T|A|47|37.0|Non-synonymous|Unprocessed|APF-G1
1776608|IGL00811|13|53367378|A->S||0.85|Possibly damaging|0.08|tolerated|MGI:1099431|Sptlc1|serine palmitoyltransferase, long chain base subunit 1 [Source:MGI Symbol;Acc:MGI:1099431]|Heterozygous|Mice homozygous for a knock-out allele exhibit prenatal lethality.  Mice homozygous for a knock-out allele exhibit abnormal sphingolipid levels.|C|A|45|39.0|Non-synonymous|Unprocessed|APF-G1
1776609|IGL00811|5|47989151|E->K||1.0|Probably damaging|0.03|deleterious|MGI:1315205|Slit2|slit homolog 2 (Drosophila) [Source:MGI Symbol;Acc:MGI:1315205]|Heterozygous|Homozygous mutants display perinatal lethality, abnormal ureteric bud development, multiple fused kidneys, multiple ureters, and hydroureter.|G|A|44|40.0|Non-synonymous|Unprocessed|APF-G1
1776610|IGL00811|2|181670420|E->G|||Benign|0.99|tolerated|MGI:103559|Sox18|SRY-box containing gene 18 [Source:MGI Symbol;Acc:MGI:103559]|Heterozygous|Homozygotes for some mutant alleles show low prenatal viability and cardiovascular defects. Most mutants show darkened coats, reduced zigzag hairs and, depending on the allele, sparse abnormal hair and edema. Heterozygotes show similar or milder defects.|T|C|38|38.5|Non-synonymous|Unprocessed|APF-G1
1776611|IGL00811|17|80253243|V->A||1.0|Probably damaging|0.02|deleterious|MGI:2147067|Dhx57|DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 [Source:MGI Symbol;Acc:MGI:2147067]|Heterozygous||A|G|33|37.0|Non-synonymous|Unprocessed|APF-G1
1776612|IGL00811|4|156168774|D->E||0.42|Benign|0.01|deleterious|MGI:87961|Agrn|agrin [Source:MGI Symbol;Acc:MGI:87961]|Heterozygous||A|T|30|39.0|Non-synonymous|Unprocessed|APF-G1
1776613|IGL00811|7|78840059|V->A|||Benign|0.65|tolerated|MGI:1923625|Det1|de-etiolated homolog 1 (Arabidopsis) [Source:MGI Symbol;Acc:MGI:1923625]|Heterozygous||A|G|30|36.0|Non-synonymous|Unprocessed|APF-G1
1776614|IGL00811|5|25374533|S->R||0.34|Benign|0.43|tolerated|MGI:2444959|Mll3|myeloid/lymphoid or mixed-lineage leukemia 3 [Source:MGI Symbol;Acc:MGI:2444959]|Heterozygous|Mice homozygous for a knock-out allele display partial embryonic lethality, delayed eyelid opening, postnatal growth retardation, impaired fertility in both sexes, and decreased proliferation of cultured mouse embryonic fibroblasts.|A|C|19|39.0|Non-synonymous|Unprocessed|APF-G1
1776615|IGL00811|7|46083308|A->V||0.52|Possibly damaging|0.59|tolerated|MGI:2385850|Nomo1|nodal modulator 1 [Source:MGI Symbol;Acc:MGI:2385850]|Heterozygous||C|T|15|38.0|Non-synonymous|Unprocessed|APF-G1
1776616|IGL00811|15|39292149|M->K||0.96|Probably damaging|0.02|deleterious|MGI:2152972|Rims2|regulating synaptic membrane exocytosis 2 [Source:MGI Symbol;Acc:MGI:2152972]|Heterozygous|Mice homozygous for a knock-out allele show reduced body size, aberrant insulin granule exocytosis, and impaired secretion of hormones associated with glucose homeostasis. Mice homozygous for another knock-out allele show a slightly reduced body size, abnormal maternal behavior and premature death.|T|A|14|39.5|Non-synonymous|Unprocessed|APF-G1
1776617|IGL00811|10|79756890|P->S||1.0|Probably damaging|0.04|deleterious|MGI:1914362|Fgf22|fibroblast growth factor 22 [Source:MGI Symbol;Acc:MGI:1914362]|Heterozygous||C|T|13|37.0|Non-synonymous|Unprocessed|APF-G1
1776618|IGL00811|4|28961285|Disrupted splicing||||||MGI:95276|Epha7|Eph receptor A7 [Source:MGI Symbol;Acc:MGI:95276]|Heterozygous|Some homozygous mutants display anencephaly. Mutants also exhibit increased proliferation of neural progenitor cells in the lateral ventricle wall of the adult brain.|T|A|150|38.0|Splice|Unprocessed|APF-G1
1776619|IGL00811|8|123199615|Disrupted splicing||||||MGI:94917|Dpep1|dipeptidase 1 (renal) [Source:MGI Symbol;Acc:MGI:94917]|Heterozygous|Mice homozygous for disruption of this gene ar phenotypically normal although defects have been noted in the conversion of leukotriene D4 to leukotrience E4.|T|C|70|38.0|Splice|Unprocessed|APF-G1
1776620|IGL00811|19|18645147|Disrupted splicing||||||MGI:2147434|Bc016495|cDNA sequence BC016495 [Source:MGI Symbol;Acc:MGI:2147434]|Heterozygous||T|A|50|39.5|Splice|Unprocessed|APF-G1
1777129|IGL00812|8|75669491|Y->H||0.88|Possibly damaging|0.12|tolerated|MGI:1919081|1700007b14rik|RIKEN cDNA 1700007B14 gene [Source:MGI Symbol;Acc:MGI:1919081]|Heterozygous||T|C|111|41.0|Non-synonymous|Unprocessed|APF-G1
1777130|IGL00812|13|112620760|L->P||1.0|Probably damaging||deleterious|MGI:102670|Ddx4|DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 [Source:MGI Symbol;Acc:MGI:102670]|Heterozygous|Spermatogenesis is blocked in homozygous mutant mice, resulting in male infertility. Female mutant mice are fertile and do not exhibit any obvious reproductive defects.|A|G|65|39.0|Non-synonymous|Unprocessed|APF-G1
1777131|IGL00812|13|21520230|S->L||1.0|Probably damaging|0.05|deleterious|MGI:1913815|Zfp192|zinc finger protein 192 [Source:MGI Symbol;Acc:MGI:1913815]|Heterozygous||G|A|54|39.0|Non-synonymous|Unprocessed|APF-G1
1777132|IGL00812|1|135879940|R->Q||0.9|Possibly damaging|0.16|tolerated|MGI:1328359|Pkp1|plakophilin 1 [Source:MGI Symbol;Acc:MGI:1328359]|Heterozygous||C|T|51|39.0|Non-synonymous|Unprocessed|APF-G1
1777133|IGL00812|5|61809740|N->I||0.74|Possibly damaging||deleterious|MGI:105977|G6pd2|glucose-6-phosphate dehydrogenase 2 [Source:MGI Symbol;Acc:MGI:105977]|Heterozygous||A|T|45|39.0|Non-synonymous|Unprocessed|APF-G1
1777134|IGL00812|19|11760416|E->G||0.78|Possibly damaging|0.03|deleterious|MGI:1202394|Gif|gastric intrinsic factor [Source:MGI Symbol;Acc:MGI:1202394]|Heterozygous||A|G|43|40.0|Non-synonymous|Unprocessed|APF-G1
1777135|IGL00812|3|94446657|C->R||0.99|Probably damaging|0.22|tolerated|MGI:2137211|Mrpl9|mitochondrial ribosomal protein L9 [Source:MGI Symbol;Acc:MGI:2137211]|Heterozygous||T|C|42|39.5|Non-synonymous|Unprocessed|APF-G1
1777136|IGL00812|4|116692965|D->N|||Benign|0.08|tolerated|MGI:99523|Prdx1|peroxiredoxin 1 [Source:MGI Symbol;Acc:MGI:99523]|Heterozygous|Mutant mice exhibit defects in antioxidant defense that manifest as hemolytic anemia and malignancies. The phenotype is more severe in homozygous mutant mice which die prematurely.|G|A|41|41.0|Non-synonymous|Unprocessed|APF-G1
1777137|IGL00812|7|7132617|C->S||1.0|Probably damaging||deleterious|MGI:1923623|Zfp773|zinc finger protein 773 [Source:MGI Symbol;Acc:MGI:1923623]|Heterozygous||A|T|41|38.0|Non-synonymous|Unprocessed|APF-G1
1777138|IGL00812|2|122344083|F->V||0.02|Benign|0.51|tolerated|MGI:2139422|Duox1|dual oxidase 1 [Source:MGI Symbol;Acc:MGI:2139422]|Heterozygous||T|G|34|38.0|Non-synonymous|Unprocessed|APF-G1
1777139|IGL00812|4|116692950|R->C||0.12|Benign|0.08|tolerated|MGI:99523|Prdx1|peroxiredoxin 1 [Source:MGI Symbol;Acc:MGI:99523]|Heterozygous|Mutant mice exhibit defects in antioxidant defense that manifest as hemolytic anemia and malignancies. The phenotype is more severe in homozygous mutant mice which die prematurely.|C|T|34|39.0|Non-synonymous|Unprocessed|APF-G1
1777140|IGL00812|X|135799900|S->P||1.0|Probably damaging|0.12|tolerated|MGI:1917418|Gprasp1|G protein-coupled receptor associated sorting protein 1 [Source:MGI Symbol;Acc:MGI:1917418]|Heterozygous|Mice homozygous for a knock-out allele exhibit impaired behavioral response to cocaine.|T|C|34|38.0|Non-synonymous|Unprocessed|APF-G1
1777141|IGL00812|11|86502952|F->I||0.91|Possibly damaging|0.01|deleterious|MGI:1270849|Rps6kb1|ribosomal protein S6 kinase, polypeptide 1 [Source:MGI Symbol;Acc:MGI:1270849]|Heterozygous|Homozygotes for a targeted null mutation exhibit reduced prenatal growth, glucose intolerance, and hypoinsulinemia associated with diminished pancreatic beta cell size.|A|T|33|40.0|Non-synonymous|Unprocessed|APF-G1
1777142|IGL00812|8|79175906|C->Stop|||N/A|||MGI:2444807|Zfp827|zinc finger protein 827 [Source:MGI Symbol;Acc:MGI:2444807]|Heterozygous||C|A|28|37.0|Non-synonymous|Unprocessed|APF-G1
1777143|IGL00812|8|72455265|D->G||0.03|Benign|0.15|tolerated|MGI:1919504|1700030k09rik|RIKEN cDNA 1700030K09 gene [Source:MGI Symbol;Acc:MGI:1919504]|Heterozygous||A|G|27|35.0|Non-synonymous|Unprocessed|APF-G1
1777144|IGL00812|5|70794653|I->K||0.99|Probably damaging|0.02|deleterious|MGI:103156|Gabrg1|gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 [Source:MGI Symbol;Acc:MGI:103156]|Heterozygous||A|T|26|40.5|Non-synonymous|Unprocessed|APF-G1
1777145|IGL00812|9|98992165|G->R||1.0|Probably damaging|0.15|tolerated|MGI:1344387|Faim|Fas apoptotic inhibitory molecule [Source:MGI Symbol;Acc:MGI:1344387]|Heterozygous|Mice homozygous for a null allele have thymocytes with an enhanced susceptibility to FAS-induced apoptosis, and B cells that more susceptible to activation induced cell death.|G|A|26|37.5|Non-synonymous|Unprocessed|APF-G1
1777146|IGL00812|4|70281139|M->T|||Benign|0.38|tolerated|MGI:2384875|Cdk5rap2|CDK5 regulatory subunit associated protein 2 [Source:MGI Symbol;Acc:MGI:2384875]|Heterozygous|Homozygous mutant phenotype varies by strain background. Severely affected mutants exhibit small size, severe anemia, and neonatal death.  Mildly affected mutants are viable with mild macrocytic anemia, reduced fertility and radiation senstitivity.|A|G|25|36.0|Non-synonymous|Unprocessed|APF-G1
1777147|IGL00812|19|7034211|Y->C||1.0|Probably damaging|0.06|tolerated|MGI:109130|Stip1|stress-induced phosphoprotein 1 [Source:MGI Symbol;Acc:MGI:109130]|Heterozygous||T|C|23|37.0|Non-synonymous|Unprocessed|APF-G1
1777148|IGL00812|14|86829089|L->Stop|||N/A|||MGI:1927222|Diap3|diaphanous homolog 3 (Drosophila) [Source:MGI Symbol;Acc:MGI:1927222]|Heterozygous||A|T|22|38.0|Non-synonymous|Unprocessed|APF-G1
1777149|IGL00812|12|70049038|I->T|||Benign|0.35|tolerated|MGI:105108|Nin|ninein [Source:MGI Symbol;Acc:MGI:105108]|Heterozygous||A|G|20|36.0|Non-synonymous|Unprocessed|APF-G1
1777150|IGL00812|8|27025132|S->P||0.73|Possibly damaging|0.08|tolerated|MGI:2387215|Erlin2|ER lipid raft associated 2 [Source:MGI Symbol;Acc:MGI:2387215]|Heterozygous||T|C|20|39.0|Non-synonymous|Unprocessed|APF-G1
1777151|IGL00812|15|63859119|R->W||1.0|Probably damaging|0.01|deleterious|MGI:3580656|Gsdmc3|gasdermin C3 [Source:MGI Symbol;Acc:MGI:3580656]|Heterozygous||G|A|19|39.0|Non-synonymous|Unprocessed|APF-G1
1777153|IGL00812|2|156029893|R->W||0.95|Possibly damaging|0.02|deleterious|MGI:1921812|Fer1l4|fer-1-like 4 (C. elegans) [Source:MGI Symbol;Acc:MGI:1921812]|Heterozygous||T|A|17|37.0|Non-synonymous|Unprocessed|APF-G1
1777154|IGL00812|2|25966861|L->Q||0.98|Probably damaging|0.1|tolerated|MGI:3036242|Camsap1|calmodulin regulated spectrin-associated protein 1 [Source:MGI Symbol;Acc:MGI:3036242]|Heterozygous||A|T|16|37.0|Non-synonymous|Unprocessed|APF-G1
1777155|IGL00812|9|110637110|F->L|||Benign|1.0|tolerated|MGI:2448554|Nbeal2|neurobeachin-like 2 [Source:MGI Symbol;Acc:MGI:2448554]|Heterozygous||A|G|11|38.0|Non-synonymous|Unprocessed|APF-G1
1777156|IGL00812|5|47989151|E->K||1.0|Probably damaging|0.03|deleterious|MGI:1315205|Slit2|slit homolog 2 (Drosophila) [Source:MGI Symbol;Acc:MGI:1315205]|Heterozygous|Homozygous mutants display perinatal lethality, abnormal ureteric bud development, multiple fused kidneys, multiple ureters, and hydroureter.|G|A|10|37.5|Non-synonymous|Unprocessed|APF-G1
1777158|IGL00812|1|64559724|Disrupted splicing||||||MGI:88494|Creb1|cAMP responsive element binding protein 1 [Source:MGI Symbol;Acc:MGI:88494]|Heterozygous|Mice homozygous for alleles lacking some or all isotypes exhibit a range of defects involving circadian rhythms, axonal growth, sensory neuron survival, long-term memory, fear conditioning, body size, respiration, and neonatal viability.|C|T|88|39.5|Splice|Unprocessed|APF-G1
1777159|IGL00812|13|106962234|Disrupted splicing||||||MGI:108390|Kif2a|kinesin family member 2A [Source:MGI Symbol;Acc:MGI:108390]|Heterozygous|Homozygous null mice display neonatal lethality, abnormal lamination of the cerebral cortex, hippocampus and cerebellum, impaired neuronal migration, and abnormal axon outgrowth.|A|T|64|39.0|Splice|Unprocessed|APF-G1
1777160|IGL00812|11|95057267|Disrupted splicing||||||MGI:96602|Itga3|integrin alpha 3 [Source:MGI Symbol;Acc:MGI:96602]|Heterozygous|Homozygotes for a targeted null mutation exhibit defects of the kidney and submandibular gland, decreased bronchial branching of the lungs, skin blisters at the dermal-epidermal junction, abnormal layering of the cerebral cortex and perinatal lethality.|T|C|12|39.0|Splice|Unprocessed|APF-G1
1777620|IGL00813|5|145774347|Stop->R|||N/A|||MGI:2449818|Cyp3a44|cytochrome P450, family 3, subfamily a, polypeptide 44 [Source:MGI Symbol;Acc:MGI:2449818]|Heterozygous||A|T|63|39.0|Non-synonymous|Unprocessed|APF-G1
1777621|IGL00813|3|66975444|Q->H||0.98|Probably damaging|0.04|deleterious|MGI:1201673|Shox2|short stature homeobox 2 [Source:MGI Symbol;Acc:MGI:1201673]|Heterozygous|Homozygous null mice display incomplete penetrance of embryonic lethality during organogenesis and incomplete clefting of the anterior part of the palate.|C|A|62|38.0|Non-synonymous|Unprocessed|APF-G1
1777622|IGL00813|11|103614498|F->V|||Benign|0.66|tolerated|MGI:2685730|Gm884|predicted gene 884 [Source:MGI Symbol;Acc:MGI:2685730]|Heterozygous||A|C|49|39.0|Non-synonymous|Unprocessed|APF-G1
1777623|IGL00813|3|94343288|K->E||0.99|Probably damaging|0.03|deleterious|MGI:1913448|Them5|thioesterase superfamily member 5 [Source:MGI Symbol;Acc:MGI:1913448]|Heterozygous||A|G|49|38.0|Non-synonymous|Unprocessed|APF-G1
1777624|IGL00813|18|63735604|L->Q||1.0|Probably damaging|0.1|tolerated|MGI:1860197|Wdr7|WD repeat domain 7 [Source:MGI Symbol;Acc:MGI:1860197]|Heterozygous||T|A|46|40.0|Non-synonymous|Unprocessed|APF-G1
1777625|IGL00813|10|127300047|M->K||1.0|Probably damaging||deleterious|MGI:1345633|Mars|methionine-tRNA synthetase [Source:MGI Symbol;Acc:MGI:1345633]|Heterozygous||A|T|40|38.5|Non-synonymous|Unprocessed|APF-G1
1777626|IGL00813|18|43310520|V->E||0.78|Possibly damaging||deleterious|MGI:2442403|Stk32a|serine/threonine kinase 32A [Source:MGI Symbol;Acc:MGI:2442403]|Heterozygous||T|A|36|39.0|Non-synonymous|Unprocessed|APF-G1
1777627|IGL00813|1|63093303|P->L||1.0|Probably damaging|0.01|deleterious|MGI:3027003|Ino80d|INO80 complex subunit D [Source:MGI Symbol;Acc:MGI:3027003]|Heterozygous||G|A|31|39.0|Non-synonymous|Unprocessed|APF-G1
1777628|IGL00813|2|173006933|D->G||1.0|Probably damaging|0.02|deleterious|MGI:1913929|Rae1|RAE1 RNA export 1 homolog (S. pombe) [Source:MGI Symbol;Acc:MGI:1913929]|Heterozygous|Mice homozygous for a knock-out allele are embryonic lethal. Heterozygous mutant mice exhibit a mitotic checkpoint defect and chromosome missegregation as well as an increased incidence of chemically-induced lung tumors; however, no spontaneous tumor formation or signs of early aging are observed.|A|G|31|38.0|Non-synonymous|Unprocessed|APF-G1
1777629|IGL00813|13|38619182|N->S||0.88|Possibly damaging|0.12|tolerated|MGI:2178598|Muted|muted [Source:MGI Symbol;Acc:MGI:2178598]|Heterozygous|Mutations at this locus cause pigment dilution, prolonged bleeding time, and inner ear abnormalities, modeling Hermansky-Pudlak Syndrome.|T|C|27|39.0|Non-synonymous|Unprocessed|APF-G1
1777630|IGL00813|13|81665242|N->K||0.98|Probably damaging|0.04|deleterious|MGI:1915906|Lysmd3|LysM, putative peptidoglycan-binding, domain containing 3 [Source:MGI Symbol;Acc:MGI:1915906]|Heterozygous||C|A|19|38.0|Non-synonymous|Unprocessed|APF-G1
1777631|IGL00813|1|127384806|M->I||0.01|Benign|0.3|tolerated|MGI:894701|Mgat5|mannoside acetylglucosaminyltransferase 5 [Source:MGI Symbol;Acc:MGI:894701]|Heterozygous|Mice homozygous for deficiencies in this gene have immune system abnormalities and reduced cancer growth and metastasis.|G|A|18|36.0|Non-synonymous|Unprocessed|APF-G1
1777632|IGL00813|5|47989151|E->K||1.0|Probably damaging|0.03|deleterious|MGI:1315205|Slit2|slit homolog 2 (Drosophila) [Source:MGI Symbol;Acc:MGI:1315205]|Heterozygous|Homozygous mutants display perinatal lethality, abnormal ureteric bud development, multiple fused kidneys, multiple ureters, and hydroureter.|G|A|18|39.5|Non-synonymous|Unprocessed|APF-G1
1777633|IGL00813|13|54546986|F->L||0.24|Benign|0.33|tolerated|MGI:2442599|4732471d19rik|RIKEN cDNA 4732471D19 gene [Source:MGI Symbol;Acc:MGI:2442599]|Heterozygous||C|A|15|39.0|Non-synonymous|Unprocessed|APF-G1
1777634|IGL00813|3|90132418|I->V|||Benign|0.5|tolerated|MGI:1924845|Nup210l|nucleoporin 210-like [Source:MGI Symbol;Acc:MGI:1924845]|Heterozygous|Mice homozygous for a transgene insertion exhibit male infertility, asthenozoospermia, teratozoospermia, azoospermia, and seminiferous tubule degeneration.|A|G|15|37.0|Non-synonymous|Unprocessed|APF-G1
1777635|IGL00813|9|98992165|G->R||1.0|Probably damaging|0.15|tolerated|MGI:1344387|Faim|Fas apoptotic inhibitory molecule [Source:MGI Symbol;Acc:MGI:1344387]|Heterozygous|Mice homozygous for a null allele have thymocytes with an enhanced susceptibility to FAS-induced apoptosis, and B cells that more susceptible to activation induced cell death.|G|A|15|39.0|Non-synonymous|Unprocessed|APF-G1
1777636|IGL00813|1|74383480|I->V|||Benign|0.48|tolerated|MGI:1345275|Slc11a1|solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 [Source:MGI Symbol;Acc:MGI:1345275]|Heterozygous|Mutations in this gene are associated with susceptibility to infection with pathogens, including Myobacterium, Salmonella and Leishmania. Depending on the mutation, mutants may exhibit either increased or decreased susceptibility to infection.|A|G|14|39.0|Non-synonymous|Unprocessed|APF-G1
1777637|IGL00813|2|60797705|K->E||0.99|Probably damaging||deleterious|MGI:1861774|Rbms1|RNA binding motif, single stranded interacting protein 1 [Source:MGI Symbol;Acc:MGI:1861774]|Heterozygous|Only about half the expected number of mice homozygous for disruptions in this gene are produced in matings of heterozygotes.  Embryo sizes are reduced.  Females have smaller than normal uteri and decreased levels of progesterone during estrus.|T|C|14|37.0|Non-synonymous|Unprocessed|APF-G1
1777638|IGL00813|2|158756965|K->R||0.97|Probably damaging|0.06|tolerated|MGI:2151841|Ppp1r16b|protein phosphatase 1, regulatory (inhibitor) subunit 16B [Source:MGI Symbol;Acc:MGI:2151841]|Heterozygous|Mice homozygous for a knock-out allele are viable, fertile and grossly normal with no detectable defects in thymopoiesis.|A|G|13|38.0|Non-synonymous|Unprocessed|APF-G1
1777639|IGL00813|15|65941961|V->E||0.28|Benign||deleterious|MGI:3615329|Hhla1|HERV-H LTR-associating 1 [Source:MGI Symbol;Acc:MGI:3615329]|Heterozygous||A|T|12|38.5|Non-synonymous|Unprocessed|APF-G1
1777640|IGL00813|8|125671932|R->Q|||Benign|0.11|tolerated|MGI:1921643|4933403g14rik|RIKEN cDNA 4933403G14 gene [Source:MGI Symbol;Acc:MGI:1921643]|Heterozygous||G|A|12|40.0|Non-synonymous|Unprocessed|APF-G1
1777641|IGL00813|9|21960591|T->A||0.68|Possibly damaging|0.13|tolerated|MGI:95408|Epor|erythropoietin receptor [Source:MGI Symbol;Acc:MGI:95408]|Heterozygous|Mutations in this locus affect erythropoiesis. Targeted null mutants die at embryonic day 11-12.5 with severe anemia. Mutants with truncated alleles are viable with mild changes in erythropoiesis. A human mutation replacement allele produces polycythemia.|T|C|10|38.0|Non-synonymous|Unprocessed|APF-G1
1777644|IGL00813|1|71353762|Disrupted splicing||||||MGI:2676312|Abca12|ATP-binding cassette, sub-family A (ABC1), member 12 [Source:MGI Symbol;Acc:MGI:2676312]|Heterozygous|Mice homozygous for a null allele exhibit neonatal lethality associated with defective skin development and abnormal lung morphology.|C|A|32|39.0|Splice|Unprocessed|APF-G1
1777645|IGL00813|4|12058587|Disrupted splicing||||||MGI:1923928|Tmem67|transmembrane protein 67 [Source:MGI Symbol;Acc:MGI:1923928]|Heterozygous||T|C|24|40.0|Splice|Unprocessed|APF-G1
1777646|IGL00813|4|40180290|Disrupted splicing||||||MGI:87879|Aco1|aconitase 1 [Source:MGI Symbol;Acc:MGI:87879]|Heterozygous|Mice homozygous for disruptions in this gene display no obvious phenotypic abnormalities.|T|C|22|38.5|Splice|Unprocessed|APF-G1
1777647|IGL00813|13|14278376|Disrupted splicing||||||MGI:2444115|Hecw1|HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 [Source:MGI Symbol;Acc:MGI:2444115]|Heterozygous||T|A|15|36.0|Splice|Unprocessed|APF-G1
1778102|IGL00814|7|103309807|I->L|||Benign|0.23|tolerated|MGI:3030430|Olfr596|olfactory receptor 596 [Source:MGI Symbol;Acc:MGI:3030430]|Heterozygous||A|T|57|39.0|Non-synonymous|Unprocessed|APF-G1
1778103|IGL00814|7|26384750|S->N||0.02|Benign|0.18|tolerated|MGI:3028627|Nlrp9c|NLR family, pyrin domain containing 9C [Source:MGI Symbol;Acc:MGI:3028627]|Heterozygous||C|T|55|39.0|Non-synonymous|Unprocessed|APF-G1
1778104|IGL00814|7|18614683|W->Stop|||N/A|||MGI:1891355|Psg23|pregnancy-specific glycoprotein 23 [Source:MGI Symbol;Acc:MGI:1891355]|Heterozygous|Mice homozygous for this spontaneous mutation display no phenotypic abnormalities.|C|T|46|39.5|Non-synonymous|Unprocessed|APF-G1
1778105|IGL00814|6|38818549|R->W||1.0|Probably damaging||deleterious|MGI:1314872|Hipk2|homeodomain interacting protein kinase 2 [Source:MGI Symbol;Acc:MGI:1314872]|Heterozygous|Homozygous null mice display decreased apoptosis and increased neuron numbers in the trigeminal ganglion.|G|A|40|38.0|Non-synonymous|Unprocessed|APF-G1
1778106|IGL00814|13|20286724|M->K||0.89|Possibly damaging||deleterious|MGI:2153044|Elmo1|engulfment and cell motility 1, ced-12 homolog (C. elegans) [Source:MGI Symbol;Acc:MGI:2153044]|Heterozygous|Mice homozygous for a knock-out allele exhibit impaired Sertoli cell phagocytosis of apoptotic male germ cells.|T|A|33|40.0|Non-synonymous|Unprocessed|APF-G1
1778107|IGL00814|9|4472202|M->K||0.09|Benign||deleterious|MGI:95811|Gria4|glutamate receptor, ionotropic, AMPA4 (alpha 4) [Source:MGI Symbol;Acc:MGI:95811]|Heterozygous|Mice homozygous for a targeted mutation display hyperactivity, decreased thermal nociception, and abnormal sensitivity to pharmacologically induced seizures.|A|T|28|40.0|Non-synonymous|Unprocessed|APF-G1
1778108|IGL00814|9|61937107|I->K||0.99|Probably damaging||deleterious|MGI:1919069|Kif23|kinesin family member 23 [Source:MGI Symbol;Acc:MGI:1919069]|Heterozygous||A|T|22|38.0|Non-synonymous|Unprocessed|APF-G1
1778109|IGL00814|2|76807167|V->A||0.97|Probably damaging|||MGI:98864|Ttn|titin [Source:MGI Symbol;Acc:MGI:98864]|Heterozygous|Homozygous mutant mice show embryogenesis defects in frontonasal mass, first branchial arch and somites, and vascular, cardiac and skeletal muscle defects causing growth retardation, muscle weakness, abnormal posture, and premature death ranging from embryonic day 11.5 to 8 weeks of age.|A|G|21|38.0|Non-synonymous|Unprocessed|APF-G1
1778110|IGL00814|9|98992165|G->R||1.0|Probably damaging|0.15|tolerated|MGI:1344387|Faim|Fas apoptotic inhibitory molecule [Source:MGI Symbol;Acc:MGI:1344387]|Heterozygous|Mice homozygous for a null allele have thymocytes with an enhanced susceptibility to FAS-induced apoptosis, and B cells that more susceptible to activation induced cell death.|G|A|21|39.0|Non-synonymous|Unprocessed|APF-G1
1778111|IGL00814|9|113687653|Q->R||0.23|Benign|0.58|tolerated|MGI:1333753|Pdcd6ip|programmed cell death 6 interacting protein [Source:MGI Symbol;Acc:MGI:1333753]|Heterozygous||T|C|16|36.5|Non-synonymous|Unprocessed|APF-G1
1778112|IGL00814|19|46897648|D->E|||Benign|0.76|tolerated|MGI:2178563|Nt5c2|5'-nucleotidase, cytosolic II [Source:MGI Symbol;Acc:MGI:2178563]|Heterozygous||A|T|15|39.0|Non-synonymous|Unprocessed|APF-G1
1778113|IGL00814|5|138163378|R->L||1.0|Probably damaging||deleterious|MGI:1349439|Cops6|COP9 (constitutive photomorphogenic) homolog, subunit 6 (Arabidopsis thaliana) [Source:MGI Symbol;Acc:MGI:1349439]|Heterozygous|Mice homozygous for a gene trap allele exhibit embryonic lethality. Mice heterozygous for a gene trap allele exhibit increased sensitivity to irradiation and decreased incidence of ionizing radiation-induced tumors.|G|T|15|40.0|Non-synonymous|Unprocessed|APF-G1
1778114|IGL00814|8|25983596|T->A||0.43|Possibly damaging|0.1|tolerated|MGI:1921903|4930444a02rik|RIKEN cDNA 4930444A02 gene [Source:MGI Symbol;Acc:MGI:1921903]|Heterozygous||T|C|15|34.0|Non-synonymous|Unprocessed|APF-G1
1778115|IGL00814|11|104186979|G->S||1.0|Probably damaging|0.39|tolerated|MGI:3045264|4933407p14rik|RIKEN cDNA 4933407P14 gene [Source:MGI Symbol;Acc:MGI:3045264]|Heterozygous||G|A|12|40.0|Non-synonymous|Unprocessed|APF-G1
1778116|IGL00814|11|93943840|S->T||0.23|Benign|0.12|tolerated|MGI:2143977|Mbtd1|mbt domain containing 1 [Source:MGI Symbol;Acc:MGI:2143977]|Heterozygous||T|A|11|38.0|Non-synonymous|Unprocessed|APF-G1
1778117|IGL00814|6|71139883|L->R||1.0|Probably damaging||deleterious|MGI:3041254|Thnsl2|threonine synthase-like 2 (bacterial) [Source:MGI Symbol;Acc:MGI:3041254]|Heterozygous||A|C|10|40.0|Non-synonymous|Unprocessed|APF-G1
1778119|IGL00814|13|47220488|Disrupted splicing||||||MGI:2384986|Rnf144b|ring finger protein 144B [Source:MGI Symbol;Acc:MGI:2384986]|Heterozygous||T|C|47|39.0|Splice|Unprocessed|APF-G1
1778120|IGL00814|14|55548299|Disrupted splicing||||||MGI:1860456|Pck2|phosphoenolpyruvate carboxykinase 2 (mitochondrial) [Source:MGI Symbol;Acc:MGI:1860456]|Heterozygous||T|C|26|38.0|Splice|Unprocessed|APF-G1
1778587|IGL00815|7|113540689|V->I||0.13|Benign|0.32|tolerated|MGI:1914670|Far1|fatty acyl CoA reductase 1 [Source:MGI Symbol;Acc:MGI:1914670]|Heterozygous||G|A|134|40.0|Non-synonymous|Unprocessed|APF-G1
1778588|IGL00815|1|163039131|V->M||1.0|Probably damaging|0.01|deleterious|MGI:1925508|4921528o07rik|RIKEN cDNA 4921528O07 gene [Source:MGI Symbol;Acc:MGI:1925508]|Heterozygous||C|T|88|38.5|Non-synonymous|Unprocessed|APF-G1
1778589|IGL00815|1|191909079|N->S||1.0|Probably damaging|0.01|deleterious|MGI:1345281|Slc30a1|solute carrier family 30 (zinc transporter), member 1 [Source:MGI Symbol;Acc:MGI:1345281]|Heterozygous|Homozygous mutation of this gene results in embryonic lethality soon after implantation with embryonic growth arrest at the egg cylinder stage. Embryos from heterozygous females on a zinc deficient diet develop abnormally.|A|G|84|37.0|Non-synonymous|Unprocessed|APF-G1
1778590|IGL00815|10|39859153|I->V||0.79|Possibly damaging|0.07|tolerated|MGI:1337131|Rev3l|REV3-like, catalytic subunit of DNA polymerase zeta RAD54 like (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1337131]|Heterozygous|Homozygous null mice are embryonic lethal at mid-gestation.|A|G|73|39.0|Non-synonymous|Unprocessed|APF-G1
1778591|IGL00815|11|105246795|Q->Stop|||N/A|||MGI:1346023|Tlk2|tousled-like kinase 2 (Arabidopsis) [Source:MGI Symbol;Acc:MGI:1346023]|Heterozygous||C|T|72|39.0|Non-synonymous|Unprocessed|APF-G1
1778592|IGL00815|2|151667989|V->A||1.0|Probably damaging||deleterious|MGI:3652039|Rad21l|RAD21-like (S. pombe) [Source:MGI Symbol;Acc:MGI:3652039]|Heterozygous||A|G|61|39.0|Non-synonymous|Unprocessed|APF-G1
1778593|IGL00815|16|48460692|I->T||0.71|Possibly damaging||deleterious|MGI:1316740|Morc1|microrchidia 1 [Source:MGI Symbol;Acc:MGI:1316740]|Heterozygous|Inactivation of this locus results in small testes and male sterility, the latter owing to meiotic arrest. Mutant females exhibited histologically normal ovaries and were fertile.|T|C|52|39.0|Non-synonymous|Unprocessed|APF-G1
1778594|IGL00815|3|135259351|I->V|||Benign|0.99|tolerated|MGI:1098230|Cenpe|centromere protein E [Source:MGI Symbol;Acc:MGI:1098230]|Heterozygous|Mice homozygous for a knock-out allele display early embryonic lethality. Mutant embryos grown in culture exhibit inner cell mass growth defects and mitotic chromosome misalignment.|A|G|51|39.0|Non-synonymous|Unprocessed|APF-G1
1778595|IGL00815|5|150980850|E->K||0.91|Possibly damaging|0.16|tolerated|MGI:1101771|Kl|klotho [Source:MGI Symbol;Acc:MGI:1101771]|Heterozygous|Homozygous mutant mice have a short lifespan and growth retardation  with one allele homeostatic imbalances and soft tissue calcification are also seen. With a second allele abnormal cancellous bone and femur morphology are seen.|G|A|47|40.0|Non-synonymous|Unprocessed|APF-G1
1778596|IGL00815|7|28360869|Q->Stop|||N/A|||MGI:2141874|Plekhg2|pleckstrin homology domain containing, family G (with RhoGef domain) member 2 [Source:MGI Symbol;Acc:MGI:2141874]|Heterozygous||G|A|43|37.0|Non-synonymous|Unprocessed|APF-G1
1778597|IGL00815|10|88675867|N->D||0.93|Possibly damaging||deleterious|MGI:1341168|Spic|Spi-C transcription factor (Spi-1/PU.1 related) [Source:MGI Symbol;Acc:MGI:1341168]|Heterozygous|Homozygote null mice have prenatal lethality with incomplete penetrance, absent red pulp macrophages, decreased phagocytosis of senescent red blood cell, and enlargement of spleens with age due to an increase in splenic iron levels.|T|C|41|37.0|Non-synonymous|Unprocessed|APF-G1
1778598|IGL00815|1|130834430|M->K||0.81|Possibly damaging||deleterious|MGI:103080|Pigr|polymeric immunoglobulin receptor [Source:MGI Symbol;Acc:MGI:103080]|Heterozygous|Homozygotes show impaired transepithelial transport of dimeric IgA, resulting in increased serum IgA concentrations and mucosal leakiness. Studies of one allele show increased susceptibility to mycobacterial infections while another allele shows impaired clearance of the protozoan parasite Giardia.|T|A|38|37.5|Non-synonymous|Unprocessed|APF-G1
1778599|IGL00815|1|176140019|D->A||0.06|Benign|0.01|deleterious|MGI:2442056|Pld5|phospholipase D family, member 5 [Source:MGI Symbol;Acc:MGI:2442056]|Heterozygous||T|G|36|35.5|Non-synonymous|Unprocessed|APF-G1
1778600|IGL00815|2|30081200|P->T||0.42|Benign|0.11|tolerated|MGI:2388285|Pkn3|protein kinase N3 [Source:MGI Symbol;Acc:MGI:2388285]|Heterozygous||C|A|34|38.0|Non-synonymous|Unprocessed|APF-G1
1778601|IGL00815|12|58992282|C->Y||0.14|Benign|0.04|deleterious|MGI:1349635|Sec23a|SEC23A (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1349635]|Heterozygous||C|T|32|35.0|Non-synonymous|Unprocessed|APF-G1
1778602|IGL00815|17|78370091|E->G||1.0|Probably damaging|0.05|deleterious|MGI:1354756|Crim1|cysteine rich transmembrane BMP regulator 1 (chordin like) [Source:MGI Symbol;Acc:MGI:1354756]|Heterozygous|Mutations in this locus cause perinatal lethality, syndactyly, and eye and kidney abnormalities.|A|G|32|39.0|Non-synonymous|Unprocessed|APF-G1
1778603|IGL00815|19|53815517|D->G||1.0|Probably damaging||deleterious|MGI:1920963|Rbm20|RNA binding motif protein 20 [Source:MGI Symbol;Acc:MGI:1920963]|Heterozygous||A|G|31|37.0|Non-synonymous|Unprocessed|APF-G1
1778604|IGL00815|6|22318948|D->E||1.0|Probably damaging||deleterious|MGI:107892|Fam3c|family with sequence similarity 3, member C [Source:MGI Symbol;Acc:MGI:107892]|Heterozygous||A|T|30|38.0|Non-synonymous|Unprocessed|APF-G1
1778605|IGL00815|9|98992165|G->R||1.0|Probably damaging|0.15|tolerated|MGI:1344387|Faim|Fas apoptotic inhibitory molecule [Source:MGI Symbol;Acc:MGI:1344387]|Heterozygous|Mice homozygous for a null allele have thymocytes with an enhanced susceptibility to FAS-induced apoptosis, and B cells that more susceptible to activation induced cell death.|G|A|30|36.5|Non-synonymous|Unprocessed|APF-G1
1778606|IGL00815|2|35902720|C->Stop|||N/A|||MGI:1921660|Ttll11|tubulin tyrosine ligase-like family, member 11 [Source:MGI Symbol;Acc:MGI:1921660]|Heterozygous||A|T|29|39.0|Non-synonymous|Unprocessed|APF-G1
1778607|IGL00815|9|44385146|E->G||0.98|Probably damaging|0.25|tolerated|MGI:108030|Hyou1|hypoxia up-regulated 1 [Source:MGI Symbol;Acc:MGI:108030]|Heterozygous|Homozygous null mice display embryonic lethality. Heterozygous mice display increased susceptibility to induced neuronal cell death.|A|G|29|35.0|Non-synonymous|Unprocessed|APF-G1
1778608|IGL00815|15|82456375|D->E||0.13|Benign||deleterious|MGI:88606|Cyp2d9|cytochrome P450, family 2, subfamily d, polypeptide 9 [Source:MGI Symbol;Acc:MGI:88606]|Heterozygous||T|A|26|36.5|Non-synonymous|Unprocessed|APF-G1
1778609|IGL00815|19|4193144|I->V||0.03|Benign|0.08|tolerated|MGI:103016|Ppp1ca|protein phosphatase 1, catalytic subunit, alpha isoform [Source:MGI Symbol;Acc:MGI:103016]|Heterozygous||A|G|25|38.0|Non-synonymous|Unprocessed|APF-G1
1778610|IGL00815|5|47989151|E->K||1.0|Probably damaging|0.03|deleterious|MGI:1315205|Slit2|slit homolog 2 (Drosophila) [Source:MGI Symbol;Acc:MGI:1315205]|Heterozygous|Homozygous mutants display perinatal lethality, abnormal ureteric bud development, multiple fused kidneys, multiple ureters, and hydroureter.|G|A|24|40.0|Non-synonymous|Unprocessed|APF-G1
1778611|IGL00815|11|102888690|D->G||0.64|Possibly damaging|0.05|deleterious|MGI:95697|Gfap|glial fibrillary acidic protein [Source:MGI Symbol;Acc:MGI:95697]|Heterozygous|Homozygotes for targeted null mutations show reduced astrocyte-associated intermediate filaments, enhanced long-term potentiation and impaired eye-blink conditioning. Aged mutants may show hydrocephaly, reduced myelination and impaired blood-brain barrier.|T|C|23|37.0|Non-synonymous|Unprocessed|APF-G1
1778612|IGL00815|9|51849413|N->D|||Benign|0.8|tolerated|MGI:2445175|Arhgap20|Rho GTPase activating protein 20 [Source:MGI Symbol;Acc:MGI:2445175]|Heterozygous||A|G|23|35.0|Non-synonymous|Unprocessed|APF-G1
1778613|IGL00815|15|41099491|M->K||0.16|Benign|0.01|deleterious|MGI:1334444|Zfpm2|zinc finger protein, multitype 2 [Source:MGI Symbol;Acc:MGI:1334444]|Heterozygous|Homozygotes for targeted null mutations exhibit cardiac defects, including absence of coronary vasculature, resulting in lethality between E12.5 and E15.5. Conditional mutations reveal errors in ovary and testis development.|T|A|18|37.0|Non-synonymous|Unprocessed|APF-G1
1778614|IGL00815|2|181029391|I->V||0.01|Benign|0.69|tolerated|MGI:87888|Chrna4|cholinergic receptor, nicotinic, alpha polypeptide 4 [Source:MGI Symbol;Acc:MGI:87888]|Heterozygous||T|C|14|38.5|Non-synonymous|Unprocessed|APF-G1
1778615|IGL00815|10|17842963|H->L||1.0|Probably damaging||deleterious|MGI:2671945|Txlnb|taxilin beta [Source:MGI Symbol;Acc:MGI:2671945]|Heterozygous||A|T|13|38.0|Non-synonymous|Unprocessed|APF-G1
1778616|IGL00815|8|72143503|I->T||0.04|Benign|0.35|tolerated|MGI:2449202|Tpm4|tropomyosin 4 [Source:MGI Symbol;Acc:MGI:2449202]|Heterozygous||T|C|13|35.0|Non-synonymous|Unprocessed|APF-G1
1778617|IGL00815|11|102197342|F->S||1.0|Probably damaging||deleterious|MGI:1333784|Hdac5|histone deacetylase 5 [Source:MGI Symbol;Acc:MGI:1333784]|Heterozygous|Homozygous null mice are viable and display cardiac hypertrophy.|A|G|12|35.5|Non-synonymous|Unprocessed|APF-G1
1778620|IGL00815|1|54996931|Disrupted splicing||||||MGI:1932339|Sf3b1|splicing factor 3b, subunit 1 [Source:MGI Symbol;Acc:MGI:1932339]|Heterozygous|Homozygous null embryos die around the 16- to 32-cell stage.  Heterozygous mice exhibit various skeletal transformations.|A|T|65|39.0|Splice|Unprocessed|APF-G1
1778621|IGL00815|17|83450790|Disrupted splicing||||||MGI:1926048|Eml4|echinoderm microtubule associated protein like 4 [Source:MGI Symbol;Acc:MGI:1926048]|Heterozygous||A|G|51|35.0|Splice|Unprocessed|APF-G1
1778622|IGL00815|2|121151218|Disrupted splicing||||||MGI:1923144|Adal|adenosine deaminase-like [Source:MGI Symbol;Acc:MGI:1923144]|Heterozygous||A|G|27|37.0|Splice|Unprocessed|APF-G1
1779111|IGL00816|6|121882638|Y->N||0.98|Probably damaging|0.04|deleterious|MGI:99837|Mug1|murinoglobulin 1 [Source:MGI Symbol;Acc:MGI:99837]|Heterozygous|Mice homozygous for a knock-out allele are viable, fertile and phenotypically normal under standard conditions but show increased mortality in response to diet-induced acute pancreatitis along with hepatic cell necrosis and inflammatory infiltration, and increased plasma amylase and lipase levels.|T|A|131|38.0|Non-synonymous|Unprocessed|APF-G1
1779112|IGL00816|10|24101275|I->N||0.97|Probably damaging||deleterious|MGI:3527452|Taar8c|trace amine-associated receptor 8C [Source:MGI Symbol;Acc:MGI:3527452]|Heterozygous||A|T|93|39.0|Non-synonymous|Unprocessed|APF-G1
1779113|IGL00816|4|19595119|V->A|||Benign|1.0|tolerated|MGI:1913552|Fam82b|family with sequence similarity 82, member B [Source:MGI Symbol;Acc:MGI:1913552]|Heterozygous||T|C|72|38.0|Non-synonymous|Unprocessed|APF-G1
1779114|IGL00816|11|28926223|V->M||0.99|Probably damaging|0.04|deleterious|MGI:1339998|Efemp1|epidermal growth factor-containing fibulin-like extracellular matrix protein 1 [Source:MGI Symbol;Acc:MGI:1339998]|Heterozygous|Mice homozygous for disruptions in this gene display a normal phenotype.  Mice homozygous for a single amino acid substitution develop deposits below the retinal pigment epithelium.|G|A|58|39.0|Non-synonymous|Unprocessed|APF-G1
1779115|IGL00816|11|57317742|M->K||1.0|Probably damaging||deleterious|MGI:95808|Gria1|glutamate receptor, ionotropic, AMPA1 (alpha 1) [Source:MGI Symbol;Acc:MGI:95808]|Heterozygous|Mice with mutations in phosphorylation sites have LTD and LTP deficits and spatial learning memory defects. Null homozygotes also show stimulus-reward learning deficits and increases locomotor activity and context-dependent sensitization to amphetamine.|T|A|41|35.0|Non-synonymous|Unprocessed|APF-G1
1779116|IGL00816|2|120526848|I->V||||0.26|tolerated|MGI:1270153|Zfp106|zinc finger protein 106 [Source:MGI Symbol;Acc:MGI:1270153]|Heterozygous||T|C|38|38.5|Non-synonymous|Unprocessed|APF-G1
1779117|IGL00816|4|145155994|M->L|||Benign|0.72|tolerated|MGI:2448530|Vps13d|vacuolar protein sorting 13 D (yeast) [Source:MGI Symbol;Acc:MGI:2448530]|Heterozygous||T|A|36|39.0|Non-synonymous|Unprocessed|APF-G1
1779118|IGL00816|1|58399054|F->L||1.0|Probably damaging||deleterious|MGI:1914132|Bzw1|basic leucine zipper and W2 domains 1 [Source:MGI Symbol;Acc:MGI:1914132]|Heterozygous||T|C|32|36.5|Non-synonymous|Unprocessed|APF-G1
1779119|IGL00816|3|94615831|I->N||0.78|Possibly damaging||deleterious|MGI:109572|Tuft1|tuftelin 1 [Source:MGI Symbol;Acc:MGI:109572]|Heterozygous||A|T|30|37.5|Non-synonymous|Unprocessed|APF-G1
1779120|IGL00816|1|186969412|I->V||0.36|Benign|0.18|tolerated|MGI:91842|D1pas1|DNA segment, Chr 1, Pasteur Institute 1 [Source:MGI Symbol;Acc:MGI:91842]|Heterozygous||A|G|29|38.0|Non-synonymous|Unprocessed|APF-G1
1779121|IGL00816|6|87893898|A->S||0.92|Possibly damaging|0.02|deleterious|MGI:1858696|Copg|coatomer protein complex, subunit gamma [Source:MGI Symbol;Acc:MGI:1858696]|Heterozygous||G|T|29|36.0|Non-synonymous|Unprocessed|APF-G1
1779122|IGL00816|15|103564232|D->A||0.95|Possibly damaging|0.08|tolerated|MGI:95759|Glycam1|glycosylation dependent cell adhesion molecule 1 [Source:MGI Symbol;Acc:MGI:95759]|Heterozygous||T|G|28|38.5|Non-synonymous|Unprocessed|APF-G1
1779123|IGL00816|5|47989151|E->K||1.0|Probably damaging|0.03|deleterious|MGI:1315205|Slit2|slit homolog 2 (Drosophila) [Source:MGI Symbol;Acc:MGI:1315205]|Heterozygous|Homozygous mutants display perinatal lethality, abnormal ureteric bud development, multiple fused kidneys, multiple ureters, and hydroureter.|G|A|27|40.0|Non-synonymous|Unprocessed|APF-G1
1779124|IGL00816|9|98992165|G->R||1.0|Probably damaging|0.15|tolerated|MGI:1344387|Faim|Fas apoptotic inhibitory molecule [Source:MGI Symbol;Acc:MGI:1344387]|Heterozygous|Mice homozygous for a null allele have thymocytes with an enhanced susceptibility to FAS-induced apoptosis, and B cells that more susceptible to activation induced cell death.|G|A|26|36.5|Non-synonymous|Unprocessed|APF-G1
1779125|IGL00816|4|99742361|S->G||0.08|Benign|0.57|tolerated|MGI:2444031|Alg6|asparagine-linked glycosylation 6 homolog (yeast, alpha-1,3,-glucosyltransferase) [Source:MGI Symbol;Acc:MGI:2444031]|Heterozygous||A|G|25|38.0|Non-synonymous|Unprocessed|APF-G1
1779126|IGL00816|2|181807515|D->G||0.81|Possibly damaging|0.41|tolerated|MGI:1100535|Myt1|myelin transcription factor 1 [Source:MGI Symbol;Acc:MGI:1100535]|Heterozygous|Mice homozygous for a knock-out allele die shortly after birth displaying improper diaphragm innervation and a failture to initiate breathing; mutant embryonic pancreata contain abnormal islet cells that express multiple hormones.|A|G|22|36.0|Non-synonymous|Unprocessed|APF-G1
1779127|IGL00816|11|20224727|T->M||0.27|Benign|0.07|tolerated|MGI:97842|Rab1|RAB1, member RAS oncogene family [Source:MGI Symbol;Acc:MGI:97842]|Heterozygous||C|T|21|40.0|Non-synonymous|Unprocessed|APF-G1
1779128|IGL00816|13|64205403|V->A||0.01|Benign|0.09|tolerated|MGI:2441808|Cdc14b|CDC14 cell division cycle 14 homolog B (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:2441808]|Heterozygous|Mice homozygous for a knock-out allele exhibit premature aging, including premature cataracts and kyphosis; reduced fertility, particularly in female mice; and impaired contextual conditioning.|A|G|20|38.5|Non-synonymous|Unprocessed|APF-G1
1779129|IGL00816|13|81397203|D->E|||Benign|0.86|tolerated|MGI:1274784|Gpr98|G protein-coupled receptor 98 [Source:MGI Symbol;Acc:MGI:1274784]|Heterozygous|Homozygotes for a spontaneous and a targeted mutation exhibit high sensitivity to audiogenic seizures. Targeted mutant mice lack the ankle links that connect growing stereocilia in the developing cochlear hair cells.|A|T|19|39.0|Non-synonymous|Unprocessed|APF-G1
1779130|IGL00816|X|12037820|I->V||0.98|Probably damaging|0.56|tolerated|MGI:1918708|Bcor|BCL6 interacting corepressor [Source:MGI Symbol;Acc:MGI:1918708]|Heterozygous||T|C|18|38.0|Non-synonymous|Unprocessed|APF-G1
1779131|IGL00816|1|132380698|A->S|||Benign|0.38|tolerated|MGI:1916125|Tmcc2|transmembrane and coiled-coil domains 2 [Source:MGI Symbol;Acc:MGI:1916125]|Heterozygous||C|A|17|37.0|Non-synonymous|Unprocessed|APF-G1
1779132|IGL00816|5|110735490|T->S|||Unknown|0.36|tolerated|MGI:1276124|Ep400|E1A binding protein p400 [Source:MGI Symbol;Acc:MGI:1276124]|Heterozygous|Mice homozygous for a knock-out allele die at E11.5 and display severe defects in yolk sac erythropoiesis, anemia, and a slight deformity of the neural tube.|T|A|17|35.0|Non-synonymous|Unprocessed|APF-G1
1779133|IGL00816|6|113111414|L->V||1.0|Probably damaging|0.06|tolerated|MGI:1920145|Setd5|SET domain containing 5 [Source:MGI Symbol;Acc:MGI:1920145]|Heterozygous||T|G|16|38.0|Non-synonymous|Unprocessed|APF-G1
1779134|IGL00816|8|95844120|I->N||1.0|Probably damaging||deleterious|MGI:2679005|Slc38a7|solute carrier family 38, member 7 [Source:MGI Symbol;Acc:MGI:2679005]|Heterozygous||A|T|16|37.0|Non-synonymous|Unprocessed|APF-G1
1779135|IGL00816|10|51678405|K->R||1.0|Probably damaging|0.2|tolerated|MGI:2445208|Rfx6|regulatory factor X, 6 [Source:MGI Symbol;Acc:MGI:2445208]|Heterozygous|Homozygotes fail to feed normally, show small bowel obstruction and die within 2 days of birth. Mutants fail to generate any of the normal islet cell types except for pancreatic-polypeptide-producing cells. Some display a reduced pancreas size; however, primary cilia formation in islets is normal.|A|G|15|39.0|Non-synonymous|Unprocessed|APF-G1
1779136|IGL00816|14|122478559|C->Stop|||N/A|||MGI:106679|Zic2|zinc finger protein of the cerebellum 2 [Source:MGI Symbol;Acc:MGI:106679]|Heterozygous|Defects in neurulation and forebrain development have been identified in both targeted and ENU induced homozygous mutants.  Death occurs perinatally in the targeted mouse and during midgestation in the ENU mouse. Mice homozygous for a knock-down allele exhibit cognitive and social behavior defects.|T|A|15|33.0|Non-synonymous|Unprocessed|APF-G1
1779137|IGL00816|8|18632397|P->S||0.97|Probably damaging|0.3|tolerated|MGI:2443308|Mcph1|microcephaly, primary autosomal recessive 1 [Source:MGI Symbol;Acc:MGI:2443308]|Heterozygous|Homozygous null mice are born at a reduced rate and display male and female infertility and arrest of male meiosis.|C|T|15|36.0|Non-synonymous|Unprocessed|APF-G1
1779138|IGL00816|11|94238095|Q->Stop|||N/A|||MGI:2669209|Wfikkn2|WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 [Source:MGI Symbol;Acc:MGI:2669209]|Heterozygous||G|A|13|37.0|Non-synonymous|Unprocessed|APF-G1
1779139|IGL00816|X|48674170|L->P||0.94|Possibly damaging|0.01|deleterious|MGI:2668412|Gpr119|G-protein coupled receptor 119 [Source:MGI Symbol;Acc:MGI:2668412]|Heterozygous||A|G|12|39.0|Non-synonymous|Unprocessed|APF-G1
1779140|IGL00816|7|80392567|G->W||1.0|Probably damaging||deleterious|MGI:97513|Furin|furin (paired basic amino acid cleaving enzyme) [Source:MGI Symbol;Acc:MGI:97513]|Heterozygous|Homozygous null embryos die at E10.5-E11.5. Embryos homozygous for one knock-out allele show multiple tissue abnormalities including abnormal yolk sac vasculature and chorioallantoic fusion, failure of axial rotation, a kinked neural tube, exencephaly and severe ventral closure and cardiac defects.|C|A|11|38.0|Non-synonymous|Unprocessed|APF-G1
1779141|IGL00816|16|45724193|C->Stop|||N/A|||MGI:1926784|Tagln3|transgelin 3 [Source:MGI Symbol;Acc:MGI:1926784]|Heterozygous||A|T|10|34.5|Non-synonymous|Unprocessed|APF-G1
1779142|IGL00816|5|109002585|M->L||0.27|Benign|0.29|tolerated|MGI:1316730|Vmn2r10|vomeronasal 2, receptor 10 [Source:MGI Symbol;Acc:MGI:1316730]|Heterozygous||T|A|10|40.0|Non-synonymous|Unprocessed|APF-G1
1779144|IGL00816|2|164743025|Disrupted splicing||||||MGI:1923897|Wfdc3|WAP four-disulfide core domain 3 [Source:MGI Symbol;Acc:MGI:1923897]|Heterozygous||T|C|31|37.0|Splice|Unprocessed|APF-G1
1779145|IGL00816|11|120495150|Disrupted splicing||||||MGI:1353497|Slc25a10|solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter), member 10 [Source:MGI Symbol;Acc:MGI:1353497]|Heterozygous||A|T|15|33.0|Splice|Unprocessed|APF-G1
1779146|IGL00816|2|79709897|Disrupted splicing||||||MGI:1923185|Ppp1r1c|protein phosphatase 1, regulatory (inhibitor) subunit 1C [Source:MGI Symbol;Acc:MGI:1923185]|Heterozygous||A|T|15|38.0|Splice|Unprocessed|APF-G1
1779147|IGL00816|13|49264786|Disrupted splicing||||||MGI:1353657|Fgd3|FYVE, RhoGEF and PH domain containing 3 [Source:MGI Symbol;Acc:MGI:1353657]|Heterozygous||A|G|11|35.0|Splice|Unprocessed|APF-G1
1779148|IGL00816|17|28059393|Disrupted splicing||||0.02|deleterious|MGI:2446180|Anks1|ankyrin repeat and SAM domain containing 1 [Source:MGI Symbol;Acc:MGI:2446180]|Heterozygous||T|C|11|35.0|Splice|Unprocessed|APF-G1
1779641|IGL00817|11|30820129|Y->H||0.02|Benign|0.1|tolerated|MGI:2143994|Psme4|proteasome (prosome, macropain) activator subunit 4 [Source:MGI Symbol;Acc:MGI:2143994]|Heterozygous|Mice homozygous for a knock-out allele show normal repair of DNA double-strand breaks but exhibit significantly reduced male fertility due to defects in spermatogenesis observed in both meiotic spermatocytes and postmeiotic haploid spermatids.|T|C|84|37.0|Non-synonymous|Unprocessed|APF-G1
1779642|IGL00817|14|54857118|R->Stop|||N/A|||MGI:2678023|Homez|homeodomain leucine zipper-encoding gene [Source:MGI Symbol;Acc:MGI:2678023]|Heterozygous||G|A|45|39.0|Non-synonymous|Unprocessed|APF-G1
1779643|IGL00817|3|137379877|T->A||0.3|Benign|0.51|tolerated|MGI:1891716|Emcn|endomucin [Source:MGI Symbol;Acc:MGI:1891716]|Heterozygous||A|G|45|40.0|Non-synonymous|Unprocessed|APF-G1
1779644|IGL00817|15|58943632|A->V|||Benign|0.29|tolerated|MGI:2384818|Mtss1|metastasis suppressor 1 [Source:MGI Symbol;Acc:MGI:2384818]|Heterozygous|Mice homozygous for a gene trap allele exhibit polycystic kidney in 50% of mice by 5 months of age. Mouse embryonic fibroblasts from mice homozygous for a different gene trap allele exhibit altered cell morphology and physiology.|G|A|36|34.5|Non-synonymous|Unprocessed|APF-G1
1779645|IGL00817|5|47989151|E->K||1.0|Probably damaging|0.03|deleterious|MGI:1315205|Slit2|slit homolog 2 (Drosophila) [Source:MGI Symbol;Acc:MGI:1315205]|Heterozygous|Homozygous mutants display perinatal lethality, abnormal ureteric bud development, multiple fused kidneys, multiple ureters, and hydroureter.|G|A|36|40.0|Non-synonymous|Unprocessed|APF-G1
1779646|IGL00817|9|98992165|G->R||1.0|Probably damaging|0.15|tolerated|MGI:1344387|Faim|Fas apoptotic inhibitory molecule [Source:MGI Symbol;Acc:MGI:1344387]|Heterozygous|Mice homozygous for a null allele have thymocytes with an enhanced susceptibility to FAS-induced apoptosis, and B cells that more susceptible to activation induced cell death.|G|A|36|39.0|Non-synonymous|Unprocessed|APF-G1
1779647|IGL00817|2|173153432|V->A||0.24|Benign|0.05|deleterious|MGI:97501|Pck1|phosphoenolpyruvate carboxykinase 1, cytosolic [Source:MGI Symbol;Acc:MGI:97501]|Heterozygous|Mice homozygous for a null allele exhibit early postnatal lethality, decreased body fat, decreased glycogen levels in the liver, and altered blood chemistry.|T|C|34|36.5|Non-synonymous|Unprocessed|APF-G1
1779648|IGL00817|4|135704285|T->A||0.42|Benign|0.03|deleterious|MGI:2429859|Il28ra|interleukin 28 receptor alpha [Source:MGI Symbol;Acc:MGI:2429859]|Heterozygous|Homozygous null mice are viable and normal with respect to viral infection, however antiviral response evoked by TLRs are significantly reduced.|A|G|34|35.0|Non-synonymous|Unprocessed|APF-G1
1779649|IGL00817|7|25388449|D->G||1.0|Probably damaging|0.01|deleterious|MGI:96790|Lipe|lipase, hormone sensitive [Source:MGI Symbol;Acc:MGI:96790]|Heterozygous|Mutations of this locus result in abnormal lipid homeostasis and, in some lines, defects in spermatogenesis.|T|C|34|35.5|Non-synonymous|Unprocessed|APF-G1
1779650|IGL00817|3|97205144|M->V||0.44|Possibly damaging|0.53|tolerated|MGI:1924828|Bcl9|B-cell CLL/lymphoma 9 [Source:MGI Symbol;Acc:MGI:1924828]|Heterozygous|Mice double homozygous for conditional Bcl9 and Bcl9l alleles activated in muscle cells exhibit impaired muscle regeneration due to increased apoptosis.|T|C|29|37.0|Non-synonymous|Unprocessed|APF-G1
1779651|IGL00817|14|121698291|T->K||||0.57|tolerated|MGI:106321|Dock9|dedicator of cytokinesis 9 [Source:MGI Symbol;Acc:MGI:106321]|Heterozygous||G|T|27|36.0|Non-synonymous|Unprocessed|APF-G1
1779652|IGL00817|1|36185932|D->E|||Benign|1.0|tolerated|MGI:2443162|Uggt1|UDP-glucose glycoprotein glucosyltransferase 1 [Source:MGI Symbol;Acc:MGI:2443162]|Heterozygous||A|T|23|39.0|Non-synonymous|Unprocessed|APF-G1
1779653|IGL00817|18|37021933|H->Q||||0.54|tolerated|MGI:2150982|Pcdha1|protocadherin alpha 1 [Source:MGI Symbol;Acc:MGI:2150982]|Heterozygous|Mice homozygous for a null allele are viable and fertile.|C|A|23|35.0|Non-synonymous|Unprocessed|APF-G1
1779654|IGL00817|7|45123501|R->Q||0.06|Benign|0.16|tolerated|MGI:1351329|Rps11|ribosomal protein S11 [Source:MGI Symbol;Acc:MGI:1351329]|Heterozygous||C|T|23|39.0|Non-synonymous|Unprocessed|APF-G1
1779655|IGL00817|9|70342148|K->R||0.04|Benign|0.18|tolerated|MGI:106621|Myo1e|myosin IE [Source:MGI Symbol;Acc:MGI:106621]|Heterozygous|Mice homozygous for a gene trapped allele exhibit embryonic lethality, embryonic hemorrhaging and hematopoietic defects.|A|G|23|38.0|Non-synonymous|Unprocessed|APF-G1
1779656|IGL00817|11|70705253|D->G||0.97|Probably damaging||deleterious|MGI:1098260|Kif1c|kinesin family member 1C [Source:MGI Symbol;Acc:MGI:1098260]|Heterozygous|Mice homozygous for a reporter allele are viable, fertile and overtly normal and display normal motor-dependent retrograde Golgi apparatus-to-endoplasmic reticulum transport.|A|G|21|36.0|Non-synonymous|Unprocessed|APF-G1
1779657|IGL00817|2|52243195|K->E||0.02|Benign|0.15|tolerated|MGI:97292|Neb|nebulin [Source:MGI Symbol;Acc:MGI:97292]|Heterozygous||T|C|20|39.0|Non-synonymous|Unprocessed|APF-G1
1779658|IGL00817|17|78934830|Y->C||1.0|Probably damaging||deleterious|MGI:109386|Cebpz|CCAAT/enhancer binding protein zeta [Source:MGI Symbol;Acc:MGI:109386]|Heterozygous||T|C|19|38.0|Non-synonymous|Unprocessed|APF-G1
1779659|IGL00817|17|31501258|L->P||0.17|Benign|0.18|tolerated|MGI:1889002|Wdr4|WD repeat domain 4 [Source:MGI Symbol;Acc:MGI:1889002]|Heterozygous||A|G|14|35.0|Non-synonymous|Unprocessed|APF-G1
1779660|IGL00817|17|34200729|V->I||0.63|Possibly damaging|0.18|tolerated|MGI:1346527|Psmb8|proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) [Source:MGI Symbol;Acc:MGI:1346527]|Heterozygous|Mice homozygous for disruptions in this gene display an essentially normal phenotype.  However they have a reduced ability to process MHC class I restricted antigens.|G|A|13|40.0|Non-synonymous|Unprocessed|APF-G1
1779662|IGL00817|10|18011631|Disrupted splicing||||||MGI:1920362|3110003a17rik|RIKEN cDNA 3110003A17 gene [Source:MGI Symbol;Acc:MGI:1920362]|Heterozygous||A|T|41|38.0|Splice|Unprocessed|APF-G1
1779663|IGL00817|8|124815060|Disrupted splicing||||||MGI:3045323|Trim67|tripartite motif-containing 67 [Source:MGI Symbol;Acc:MGI:3045323]|Heterozygous||T|C|25|38.0|Splice|Unprocessed|APF-G1
1779664|IGL00817|16|20721905|Disrupted splicing||||||MGI:2384309|Polr2h|polymerase (RNA) II (DNA directed) polypeptide H [Source:MGI Symbol;Acc:MGI:2384309]|Heterozygous||T|C|17|35.0|Splice|Unprocessed|APF-G1
1780171|IGL00818|7|34184733|M->K||0.74|Possibly damaging|0.01|deleterious|MGI:1915329|Pdcd2l|programmed cell death 2-like [Source:MGI Symbol;Acc:MGI:1915329]|Heterozygous||A|T|68|38.0|Non-synonymous|Unprocessed|APF-G1
1780172|IGL00818|11|61487781|Q->L||0.01|Benign|0.45|tolerated|MGI:1342276|Mfap4|microfibrillar-associated protein 4 [Source:MGI Symbol;Acc:MGI:1342276]|Heterozygous||A|T|49|38.0|Non-synonymous|Unprocessed|APF-G1
1780173|IGL00818|16|15759754|T->S||0.36|Benign|0.15|tolerated|MGI:104779|Prkdc|protein kinase, DNA activated, catalytic polypeptide [Source:MGI Symbol;Acc:MGI:104779]|Heterozygous|Mutations at this locus effect genome stability, radiation sensitivity and DNA repair. Nonsense (scid) and null homozygotes have severe combined immunodeficiency. A BALB/c variant allele reduces enzyme activity and predisposes to breast cancer.|A|T|46|36.0|Non-synonymous|Unprocessed|APF-G1
1780174|IGL00818|1|107524736|D->G||1.0|Probably damaging|0.05|deleterious|MGI:97609|Serpinb2|serine (or cysteine) peptidase inhibitor, clade B, member 2 [Source:MGI Symbol;Acc:MGI:97609]|Heterozygous|Mice homozygous for a knock-out allele exhibit a slight to mild reduction in platelets, leukocytes, lymphocytes, neutrophils, and monocytes numbers.|A|G|43|37.0|Non-synonymous|Unprocessed|APF-G1
1780175|IGL00818|2|76721748|T->S|||Unknown|||MGI:98864|Ttn|titin [Source:MGI Symbol;Acc:MGI:98864]|Heterozygous|Homozygous mutant mice show embryogenesis defects in frontonasal mass, first branchial arch and somites, and vascular, cardiac and skeletal muscle defects causing growth retardation, muscle weakness, abnormal posture, and premature death ranging from embryonic day 11.5 to 8 weeks of age.|T|A|36|36.0|Non-synonymous|Unprocessed|APF-G1
1780176|IGL00818|6|55050353|G->V||1.0|Probably damaging||deleterious|MGI:2449057|Gars|glycyl-tRNA synthetase [Source:MGI Symbol;Acc:MGI:2449057]|Heterozygous|A dominant mutation results in sensory and motor axon degeneration in affected mice, with defects in synaptic transmission, nerve conduction and premature death.  A loss of function mutation results in embryonic lethality in homozygous mice, and no discernable phenotype in heterozygous mice.|G|T|34|36.5|Non-synonymous|Unprocessed|APF-G1
1780177|IGL00818|10|29317620|I->V|||Benign|0.35|tolerated|MGI:1277169|Echdc1|enoyl Coenzyme A hydratase domain containing 1 [Source:MGI Symbol;Acc:MGI:1277169]|Heterozygous||A|G|32|38.0|Non-synonymous|Unprocessed|APF-G1
1780178|IGL00818|4|68762847|D->V||0.95|Possibly damaging|0.04|deleterious|MGI:1928478|Dbc1|deleted in bladder cancer 1 (human) [Source:MGI Symbol;Acc:MGI:1928478]|Heterozygous||T|A|31|37.0|Non-synonymous|Unprocessed|APF-G1
1780179|IGL00818|7|119450127|T->A||0.4|Benign|0.41|tolerated|MGI:1914383|Gp2|glycoprotein 2 (zymogen granule membrane) [Source:MGI Symbol;Acc:MGI:1914383]|Heterozygous||T|C|30|38.0|Non-synonymous|Unprocessed|APF-G1
1780180|IGL00818|18|71955012|M->L|||Benign|0.45|tolerated|MGI:94869|Dcc|deleted in colorectal carcinoma [Source:MGI Symbol;Acc:MGI:94869]|Heterozygous|Homozygous animals show defects in axonal projections and hypothalamic development affecting both visual and neruoendocrine systems.|T|A|27|39.0|Non-synonymous|Unprocessed|APF-G1
1780181|IGL00818|1|128032867|Y->C||1.0|Probably damaging||deleterious|MGI:1918362|Zranb3|zinc finger, RAN-binding domain containing 3 [Source:MGI Symbol;Acc:MGI:1918362]|Heterozygous||T|C|25|38.0|Non-synonymous|Unprocessed|APF-G1
1780182|IGL00818|X|150648361|G->D||1.0|Probably damaging|0.01|deleterious|MGI:1928994|Tro|trophinin [Source:MGI Symbol;Acc:MGI:1928994]|Heterozygous|Homozygous female or hemizygous male mice on a mixed 129 and NIH black Swiss background are viable, fertile and elderly mice exhibit no disorders.  On an inbred 129 background, homozygous female or hemizygous male mice show partial embryonic lethality between E3.5 and E8.5.|C|T|25|36.0|Non-synonymous|Unprocessed|APF-G1
1780183|IGL00818|8|110223100|T->S||0.02|Benign|0.43|tolerated|MGI:2384580|Ftsjd1|FtsJ methyltransferase domain containing 1 [Source:MGI Symbol;Acc:MGI:2384580]|Heterozygous||A|T|23|37.0|Non-synonymous|Unprocessed|APF-G1
1780184|IGL00818|7|75609727|T->A|||Benign|1.0|tolerated|MGI:2676556|Akap13|A kinase (PRKA) anchor protein 13 [Source:MGI Symbol;Acc:MGI:2676556]|Heterozygous||A|G|19|39.0|Non-synonymous|Unprocessed|APF-G1
1780185|IGL00818|10|100471480|T->S||||0.99|tolerated|MGI:3036255|Tmtc3|transmembrane and tetratricopeptide repeat containing 3 [Source:MGI Symbol;Acc:MGI:3036255]|Heterozygous||T|A|13|37.0|Non-synonymous|Unprocessed|APF-G1
1780187|IGL00818|7|35276813|Disrupted splicing||||||MGI:1914721|Gpatch1|G patch domain containing 1 [Source:MGI Symbol;Acc:MGI:1914721]|Heterozygous||T|C|46|39.5|Splice|Unprocessed|APF-G1
1780188|IGL00818|10|121266824|Disrupted splicing||||||MGI:1921944|Tbc1d30|TBC1 domain family, member 30 [Source:MGI Symbol;Acc:MGI:1921944]|Heterozygous||G|A|28|36.5|Splice|Unprocessed|APF-G1
1780189|IGL00818|1|167627288|Disrupted splicing||||||MGI:98216|Rxrg|retinoid X receptor gamma [Source:MGI Symbol;Acc:MGI:98216]|Heterozygous||C|T|17|39.0|Splice|Unprocessed|APF-G1
1780702|IGL00819|6|106776222|Y->Stop|||N/A|||MGI:1917297|Trnt1|tRNA nucleotidyl transferase, CCA-adding, 1 [Source:MGI Symbol;Acc:MGI:1917297]|Heterozygous||T|A|231|39.0|Non-synonymous|Unprocessed|APF-G1
1780703|IGL00819|15|58054694|V->A|||Benign|0.52|tolerated|MGI:109271|Zhx1|zinc fingers and homeoboxes 1 [Source:MGI Symbol;Acc:MGI:109271]|Heterozygous||A|G|129|39.0|Non-synonymous|Unprocessed|APF-G1
1780704|IGL00819|7|101992710|G->W||0.99|Probably damaging||deleterious|MGI:2443665|Numa1|nuclear mitotic apparatus protein 1 [Source:MGI Symbol;Acc:MGI:2443665]|Heterozygous|Mice homozygous for a knock-out or hypomorphic allele exhibit embryonic lethality by E9.5.|G|T|98|39.0|Non-synonymous|Unprocessed|APF-G1
1780705|IGL00819|2|76743050|I->T|||Unknown|||MGI:98864|Ttn|titin [Source:MGI Symbol;Acc:MGI:98864]|Heterozygous|Homozygous mutant mice show embryogenesis defects in frontonasal mass, first branchial arch and somites, and vascular, cardiac and skeletal muscle defects causing growth retardation, muscle weakness, abnormal posture, and premature death ranging from embryonic day 11.5 to 8 weeks of age.|A|G|95|39.0|Non-synonymous|Unprocessed|APF-G1
1780706|IGL00819|9|53518531|S->P||1.0|Probably damaging|0.23|tolerated|MGI:107202|Atm|ataxia telangiectasia mutated homolog (human) [Source:MGI Symbol;Acc:MGI:107202]|Heterozygous|Homozygotes for null mutations may exhibit locomotor abnormalities, motor learning deficits, growth retardation, sterility due to meiotic arrest, and susceptibility to thymic lymphomas.|A|G|87|39.0|Non-synonymous|Unprocessed|APF-G1
1780707|IGL00819|13|22556947|Y->Stop|||N/A|||MGI:3651399|Vmn1r204|vomeronasal 1 receptor 204 [Source:MGI Symbol;Acc:MGI:3651399]|Heterozygous||T|A|84|39.0|Non-synonymous|Unprocessed|APF-G1
1780708|IGL00819|2|118249912|R->L||0.16|Benign|0.08|tolerated|MGI:1918563|Fsip1|fibrous sheath-interacting protein 1 [Source:MGI Symbol;Acc:MGI:1918563]|Heterozygous||C|A|81|40.0|Non-synonymous|Unprocessed|APF-G1
1780709|IGL00819|5|14858846|N->S||0.97|Probably damaging|||MGI:1349390|Pclo|piccolo (presynaptic cytomatrix protein) [Source:MGI Symbol;Acc:MGI:1349390]|Heterozygous|Mice homozygous for one deletion of Pclo are viable and fertile, and display no overt abnormal phenotype. Mice homozygous for another knock-out allele exhibit some premature lethality, decreased body size, and abnormal synaptic vesicle number.|A|G|61|39.0|Non-synonymous|Unprocessed|APF-G1
1780710|IGL00819|6|88909336|M->K||1.0|Probably damaging||deleterious|MGI:1345190|Tpra1|transmembrane protein, adipocyte asscociated 1 [Source:MGI Symbol;Acc:MGI:1345190]|Heterozygous||T|A|60|38.0|Non-synonymous|Unprocessed|APF-G1
1780711|IGL00819|5|90604071|K->E||0.01|Benign|0.53|tolerated|MGI:1920496|Rassf6|Ras association (RalGDS/AF-6) domain family member 6 [Source:MGI Symbol;Acc:MGI:1920496]|Heterozygous||T|C|58|40.0|Non-synonymous|Unprocessed|APF-G1
1780712|IGL00819|1|54263573|N->K||0.98|Probably damaging|0.02|deleterious|MGI:1925266|Ccdc150|coiled-coil domain containing 150 [Source:MGI Symbol;Acc:MGI:1925266]|Heterozygous||T|A|55|38.0|Non-synonymous|Unprocessed|APF-G1
1780713|IGL00819|5|73148108|V->D||||0.01|deleterious|MGI:1919563|Fryl|furry homolog-like (Drosophila) [Source:MGI Symbol;Acc:MGI:1919563]|Heterozygous||A|T|48|37.0|Non-synonymous|Unprocessed|APF-G1
1780714|IGL00819|11|23743029|F->I||0.02|Benign|0.25|tolerated|MGI:97897|Rel|reticuloendotheliosis oncogene [Source:MGI Symbol;Acc:MGI:97897]|Heterozygous||A|T|47|40.0|Non-synonymous|Unprocessed|APF-G1
1780715|IGL00819|1|172496636|S->P|||Benign|0.47|tolerated|MGI:2135283|Igsf9|immunoglobulin superfamily, member 9 [Source:MGI Symbol;Acc:MGI:2135283]|Heterozygous|Mice homozygous for targeted null mutations are viable and fertile.|T|C|42|37.0|Non-synonymous|Unprocessed|APF-G1
1780716|IGL00819|1|175896237|V->A|||Benign|0.93|tolerated|MGI:1349427|Exo1|exonuclease 1 [Source:MGI Symbol;Acc:MGI:1349427]|Heterozygous|Homozygous mutation of this gene results in reduced life span, lymphoma development, and male/female sterilty due to defective meiosis.|T|C|41|38.0|Non-synonymous|Unprocessed|APF-G1
1780717|IGL00819|11|98557592|H->L||0.76|Possibly damaging|0.02|deleterious|MGI:1916626|Zpbp2|zona pellucida binding protein 2 [Source:MGI Symbol;Acc:MGI:1916626]|Heterozygous|Male mice homozygous for a null mutation display reduced fecundity, mild teratozoospermia, and delayed fertilization.|A|T|41|39.0|Non-synonymous|Unprocessed|APF-G1
1780718|IGL00819|1|171384686|L->S||1.0|Probably damaging|0.72|tolerated|MGI:1918990|Pvrl4|poliovirus receptor-related 4 [Source:MGI Symbol;Acc:MGI:1918990]|Heterozygous||T|C|37|37.0|Non-synonymous|Unprocessed|APF-G1
1780719|IGL00819|10|108240821|S->P||0.81|Possibly damaging|0.05|tolerated|MGI:1309528|Ppp1r12a|protein phosphatase 1, regulatory (inhibitor) subunit 12A [Source:MGI Symbol;Acc:MGI:1309528]|Heterozygous|Homozygous null mice die before E7.5.|T|C|34|38.0|Non-synonymous|Unprocessed|APF-G1
1780720|IGL00819|1|84754272|G->S||1.0|Probably damaging|0.3|tolerated|MGI:1309481|Trip12|thyroid hormone receptor interactor 12 [Source:MGI Symbol;Acc:MGI:1309481]|Heterozygous||C|T|33|40.0|Non-synonymous|Unprocessed|APF-G1
1780721|IGL00819|13|83625380|D->V||1.0|Probably damaging||deleterious|MGI:99458|Mef2c|myocyte enhancer factor 2C [Source:MGI Symbol;Acc:MGI:99458]|Heterozygous|Mice homozygous for disruptions in this gene have cardiovascular abnormalities and die as embryos.|A|T|33|38.0|Non-synonymous|Unprocessed|APF-G1
1780722|IGL00819|11|82046575|N->S||0.37|Benign|0.02|deleterious|MGI:99512|Ccl7|chemokine (C-C motif) ligand 7 [Source:MGI Symbol;Acc:MGI:99512]|Heterozygous||A|G|32|38.5|Non-synonymous|Unprocessed|APF-G1
1780723|IGL00819|1|93346256|D->E||0.01|Benign|0.78|tolerated|MGI:1913635|Ppp1r7|protein phosphatase 1, regulatory (inhibitor) subunit 7 [Source:MGI Symbol;Acc:MGI:1913635]|Heterozygous||T|A|30|38.0|Non-synonymous|Unprocessed|APF-G1
1780724|IGL00819|7|121740437|E->G|||Benign|0.3|tolerated|MGI:104695|Scnn1g|sodium channel, nonvoltage-gated 1 gamma [Source:MGI Symbol;Acc:MGI:104695]|Heterozygous|Homozygous mutation of this gene results in partial lethality between 24-36 hours after birth. Newborns exhibit hyperkalemia, clear lung liquid more slowly, and show low urinary potassium and high urinary sodium concentrations.|A|G|28|35.0|Non-synonymous|Unprocessed|APF-G1
1780725|IGL00819|15|84018642|I->T||0.81|Possibly damaging|0.04|deleterious|MGI:1924877|Efcab6|EF-hand calcium binding domain 6 [Source:MGI Symbol;Acc:MGI:1924877]|Heterozygous||A|G|27|40.0|Non-synonymous|Unprocessed|APF-G1
1780726|IGL00819|14|20737330|G->S|||Benign|0.26|tolerated|MGI:88259|Camk2g|calcium/calmodulin-dependent protein kinase II gamma [Source:MGI Symbol;Acc:MGI:88259]|Heterozygous|Mice homozygous for a knock-out allele exhibit female infertility and decreased sensitivity of macrophages to ER stress-induced apoptosis.|C|T|26|37.5|Non-synonymous|Unprocessed|APF-G1
1780727|IGL00819|5|47989151|E->K||1.0|Probably damaging|0.03|deleterious|MGI:1315205|Slit2|slit homolog 2 (Drosophila) [Source:MGI Symbol;Acc:MGI:1315205]|Heterozygous|Homozygous mutants display perinatal lethality, abnormal ureteric bud development, multiple fused kidneys, multiple ureters, and hydroureter.|G|A|25|40.0|Non-synonymous|Unprocessed|APF-G1
1780728|IGL00819|11|70394618|P->L|||Unknown|0.06|tolerated|MGI:1922523|Pelp1|proline, glutamic acid and leucine rich protein 1 [Source:MGI Symbol;Acc:MGI:1922523]|Heterozygous||G|A|24|33.0|Non-synonymous|Unprocessed|APF-G1
1780729|IGL00819|3|89007736|V->E||0.67|Possibly damaging||deleterious|MGI:2183158|Ash1l|ash1 (absent, small, or homeotic)-like (Drosophila) [Source:MGI Symbol;Acc:MGI:2183158]|Heterozygous||T|A|24|38.0|Non-synonymous|Unprocessed|APF-G1
1780730|IGL00819|10|61092140|E->A||0.39|Benign|0.84|tolerated|MGI:94873|Pcbd1|pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 1 [Source:MGI Symbol;Acc:MGI:94873]|Heterozygous|Homozygous mutant mice display hyperphenylalaninemia, are mildly glucose intolerant, and are predisposed to cataract formation.|A|C|23|38.0|Non-synonymous|Unprocessed|APF-G1
1780731|IGL00819|4|139476282|T->I||1.0|Probably damaging||deleterious|MGI:1916366|Ubr4|ubiquitin protein ligase E3 component n-recognin 4 [Source:MGI Symbol;Acc:MGI:1916366]|Heterozygous||C|T|20|37.5|Non-synonymous|Unprocessed|APF-G1
1780732|IGL00819|1|64042317|D->G||0.28|Benign||deleterious|MGI:1935151|Klf7|Kruppel-like factor 7 (ubiquitous) [Source:MGI Symbol;Acc:MGI:1935151]|Heterozygous|Homozygous null mice die within 3 days of life, showing lack of gastic milk, hypopnea, cyanosis, olfactory bulb hypoplasia, no response to tail clamping, impaired axon projection in the olfactory and visual systems, cerebral cortex and hippocampus, and reduced dendritic branching in the hippocampus.|T|C|19|39.0|Non-synonymous|Unprocessed|APF-G1
1780733|IGL00819|6|47931322|P->S||1.0|Probably damaging|0.15|tolerated|MGI:2682609|Zfp212|Zinc finger protein 212 [Source:MGI Symbol;Acc:MGI:2682609]|Heterozygous||C|T|18|39.0|Non-synonymous|Unprocessed|APF-G1
1780734|IGL00819|4|150125656|Y->H||1.0|Probably damaging||deleterious|MGI:1928369|Slc2a5|solute carrier family 2 (facilitated glucose transporter), member 5 [Source:MGI Symbol;Acc:MGI:1928369]|Heterozygous|Mice homozygous for a knock-out allele exhibit normal cochlear morphology and physiology with no detectable alterations in outer hair cell morphology, electromotility or nonlinear capacitance.|T|C|11|35.0|Non-synonymous|Unprocessed|APF-G1
1780738|IGL00819|3|96683034|Disrupted splicing||||||MGI:2442590|Ankrd35|ankyrin repeat domain 35 [Source:MGI Symbol;Acc:MGI:2442590]|Heterozygous||A|T|63|37.0|Splice|Unprocessed|APF-G1
1780739|IGL00819|11|69473350|Disrupted splicing||||||MGI:107731|Dnahc2|dynein, axonemal, heavy chain 2 [Source:MGI Symbol;Acc:MGI:107731]|Heterozygous||A|T|31|39.0|Splice|Unprocessed|APF-G1
1780740|IGL00819|11|93931811|Disrupted splicing||||||MGI:2143977|Mbtd1|mbt domain containing 1 [Source:MGI Symbol;Acc:MGI:2143977]|Heterozygous||A|G|29|39.0|Splice|Unprocessed|APF-G1
1780741|IGL00819|9|113983979|Disrupted splicing||||||MGI:1919429|Fbxl2|F-box and leucine-rich repeat protein 2 [Source:MGI Symbol;Acc:MGI:1919429]|Heterozygous||A|G|25|39.0|Splice|Unprocessed|APF-G1
1780742|IGL00819|10|90997340|Disrupted splicing||||||MGI:1306796|Apaf1|apoptotic peptidase activating factor 1 [Source:MGI Symbol;Acc:MGI:1306796]|Heterozygous|Homozygotes for targeted null mutations have defects in apoptosis resulting in brain overgrowth, craniofacial defects, interdigit webbing and altered lens and retina. Most mutants die by embryonic day 16.5 or perinatally, and male survivors are sterile.|G|T|20|38.5|Splice|Unprocessed|APF-G1
1781245|IGL00820|18|67675792|I->R|||Benign|0.67|tolerated|MGI:97806|Ptpn2|protein tyrosine phosphatase, non-receptor type 2 [Source:MGI Symbol;Acc:MGI:97806]|Heterozygous|Mice homozygous for disruptions in this gene have a reduced life span, abnormalities of the hematopoietic system and an increased succeptibility to inflammatory disease.|A|C|82|39.0|Non-synonymous|Unprocessed|APF-G1
1781246|IGL00820|5|104936012|I->F||0.05|Benign|0.23|tolerated|MGI:1351624|Abcg3|ATP-binding cassette, sub-family G (WHITE), member 3 [Source:MGI Symbol;Acc:MGI:1351624]|Heterozygous||T|A|76|39.0|Non-synonymous|Unprocessed|APF-G1
1781247|IGL00820|1|180999821|Y->C||0.52|Possibly damaging|0.03|deleterious|MGI:95405|Ephx1|epoxide hydrolase 1, microsomal [Source:MGI Symbol;Acc:MGI:95405]|Heterozygous||T|C|63|37.0|Non-synonymous|Unprocessed|APF-G1
1781248|IGL00820|1|52708306|V->M||1.0|Probably damaging||deleterious|MGI:1922925|Mfsd6|major facilitator superfamily domain containing 6 [Source:MGI Symbol;Acc:MGI:1922925]|Heterozygous||C|T|46|36.5|Non-synonymous|Unprocessed|APF-G1
1781249|IGL00820|7|43954786|I->T||0.05|Benign|0.06|tolerated|MGI:892018|Klk1b8|kallikrein 1-related peptidase b8 [Source:MGI Symbol;Acc:MGI:892018]|Heterozygous||T|C|46|38.0|Non-synonymous|Unprocessed|APF-G1
1781250|IGL00820|4|41758570|A->V||0.53|Possibly damaging|0.01|deleterious|MGI:95638|Galt|galactose-1-phosphate uridyl transferase [Source:MGI Symbol;Acc:MGI:95638]|Heterozygous|Homozygotes for a targeted null mutation exhibit abnormal galactose metabolism, but lack symptoms of acute toxicity seen in humans with galactosemia.|C|T|35|39.0|Non-synonymous|Unprocessed|APF-G1
1781251|IGL00820|19|11774413|V->A||0.61|Possibly damaging|0.06|tolerated|MGI:2137219|Mrpl16|mitochondrial ribosomal protein L16 [Source:MGI Symbol;Acc:MGI:2137219]|Heterozygous||T|C|34|39.0|Non-synonymous|Unprocessed|APF-G1
1781252|IGL00820|11|82178088|E->G||0.42|Benign|0.07|tolerated|MGI:98258|Ccl1|chemokine (C-C motif) ligand 1 [Source:MGI Symbol;Acc:MGI:98258]|Heterozygous|Mice homozygous for a targeted null allele are refractory to the anti-inflammatory response of the statin drug lovastatin and fail to exhibit an increase in regulatory T cell recruitment to sites of inflammation in a model of delayed-type hypersensitivity.|T|C|32|39.0|Non-synonymous|Unprocessed|APF-G1
1781253|IGL00820|12|44861346|T->I||0.92|Possibly damaging|0.19|tolerated|MGI:2384963|Stxbp6|syntaxin binding protein 6 (amisyn) [Source:MGI Symbol;Acc:MGI:2384963]|Heterozygous||G|A|32|39.0|Non-synonymous|Unprocessed|APF-G1
1781254|IGL00820|5|137386364|C->S|||Unknown||deleterious|MGI:106656|Zan|zonadhesin [Source:MGI Symbol;Acc:MGI:106656]|Heterozygous|Sperm from mice homozygous for a knock-out allele exhibit decreased species-specific zona pellucida adhesion without alteration in fertility.|A|T|30|39.0|Non-synonymous|Unprocessed|APF-G1
1781255|IGL00820|9|109693369|T->I||1.0|Probably damaging|1.0|tolerated|MGI:3505704|Fbxw18|F-box and WD-40 domain protein 18 [Source:MGI Symbol;Acc:MGI:3505704]|Heterozygous||G|A|29|39.0|Non-synonymous|Unprocessed|APF-G1
1781256|IGL00820|13|23819334|H->R||0.68|Possibly damaging|0.45|tolerated|MGI:2443098|Slc17a2|solute carrier family 17 (sodium phosphate), member 2 [Source:MGI Symbol;Acc:MGI:2443098]|Heterozygous||A|G|27|39.0|Non-synonymous|Unprocessed|APF-G1
1781257|IGL00820|2|158008968|E->G||1.0|Probably damaging||deleterious|MGI:1922675|Tti1|Tel2 interacting protein 1 homolog (S. pombe) [Source:MGI Symbol;Acc:MGI:1922675]|Heterozygous||T|C|22|40.0|Non-synonymous|Unprocessed|APF-G1
1781258|IGL00820|12|76632477|L->P||1.0|Probably damaging||deleterious|MGI:98387|Spnb1|spectrin beta 1 [Source:MGI Symbol;Acc:MGI:98387]|Heterozygous|Homozygotes for a spontaneous mutation exhibit a severe microcytic anemia with erythrocyte fragility, hepatomegaly, and jaundice. Mutants die within a few days of birth. Heterozygotes are mildly anemic.|A|G|21|35.0|Non-synonymous|Unprocessed|APF-G1
1781259|IGL00820|7|103383465|T->I||1.0|Probably damaging||deleterious|MGI:3030437|Olfr603|olfactory receptor 603 [Source:MGI Symbol;Acc:MGI:3030437]|Heterozygous||G|A|21|37.0|Non-synonymous|Unprocessed|APF-G1
1781260|IGL00820|2|12232892|V->A||0.8|Possibly damaging||deleterious|MGI:109442|Itga8|integrin alpha 8 [Source:MGI Symbol;Acc:MGI:109442]|Heterozygous|Mice homozygous for disruptions in this gene usually die by the end of the second day after birth.  Those that do survive have reduced kidneys and abnormal steriocilia in the inner ear.|A|G|20|38.5|Non-synonymous|Unprocessed|APF-G1
1781261|IGL00820|8|3532358|T->A||1.0|Probably damaging||deleterious|MGI:1354723|Pnpla6|patatin-like phospholipase domain containing 6 [Source:MGI Symbol;Acc:MGI:1354723]|Heterozygous|Homozygous mutation of this gene results in embryonic lethality during early gestation. Conditional inactivation in the central nervous system leads to neurodegeneration.|A|G|20|38.0|Non-synonymous|Unprocessed|APF-G1
1781262|IGL00820|5|47989151|E->K||1.0|Probably damaging|0.03|deleterious|MGI:1315205|Slit2|slit homolog 2 (Drosophila) [Source:MGI Symbol;Acc:MGI:1315205]|Heterozygous|Homozygous mutants display perinatal lethality, abnormal ureteric bud development, multiple fused kidneys, multiple ureters, and hydroureter.|G|A|19|40.0|Non-synonymous|Unprocessed|APF-G1
1781263|IGL00820|13|42183818|I->L||1.0|Probably damaging|0.52|tolerated|MGI:96100|Hivep1|human immunodeficiency virus type I enhancer binding protein 1 [Source:MGI Symbol;Acc:MGI:96100]|Heterozygous||A|T|12|38.5|Non-synonymous|Unprocessed|APF-G1
1781264|IGL00820|17|25248690|D->G||0.2|Benign|0.09|tolerated|MGI:2685783|Baiap3|BAI1-associated protein 3 [Source:MGI Symbol;Acc:MGI:2685783]|Heterozygous||T|C|11|39.0|Non-synonymous|Unprocessed|APF-G1
1781265|IGL00820|4|41507178|L->Q||1.0|Probably damaging||deleterious|MGI:1920971|1110017d15rik|RIKEN cDNA 1110017D15 gene [Source:MGI Symbol;Acc:MGI:1920971]|Heterozygous||A|T|10|39.5|Non-synonymous|Unprocessed|APF-G1
1781267|IGL00820|8|33579006|Disrupted splicing||||||MGI:1934816|Tex15|testis expressed gene 15 [Source:MGI Symbol;Acc:MGI:1934816]|Heterozygous|Male mice are infertile due to arrest of meiosis stemming from failure to repair double-strand breaks.  However, female mice are fertile.|A|G|134|39.0|Splice|Unprocessed|APF-G1
1781268|IGL00820|4|149352921|Disrupted splicing||||||MGI:1927086|Ube4b|ubiquitination factor E4B, UFD2 homolog (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1927086]|Heterozygous|Mice homozygous for a disruption in this gene die by midgestation and exhibit cardiac development defects such as hemorrhage and cardiomyocyte apoptosis. Heterozygous mice exhibit axonal dystrophy in the nucleus gracilis, degeneration of Purkinje cells and gait abnormalities.|T|C|35|39.0|Splice|Unprocessed|APF-G1
1781269|IGL00820|19|58263905|Disrupted splicing||||||MGI:1100842|Gfra1|glial cell line derived neurotrophic factor family receptor alpha 1 [Source:MGI Symbol;Acc:MGI:1100842]|Heterozygous|Homozygotes for targeted null mutations lack kidneys and enteric neurons resulting in neonatal lethality.|T|C|22|39.0|Splice|Unprocessed|APF-G1
1781270|IGL00820|11|109583119|Disrupted splicing||||||MGI:1261864|Wipi1|WD repeat domain, phosphoinositide interacting 1 [Source:MGI Symbol;Acc:MGI:1261864]|Heterozygous||A|C|10|39.5|Splice|Unprocessed|APF-G1
1781744|IGL00821|3|145150987|S->T||1.0|Probably damaging|0.05|deleterious|MGI:1098600|Odf2l|outer dense fiber of sperm tails 2-like [Source:MGI Symbol;Acc:MGI:1098600]|Heterozygous||T|A|107|40.0|Non-synonymous|Unprocessed|APF-G1
1781745|IGL00821|16|20298208|P->S|||Benign|0.17|tolerated|MGI:1277152|Parl|presenilin associated, rhomboid-like [Source:MGI Symbol;Acc:MGI:1277152]|Heterozygous|Homozygous null mice show stunted growth, lymphocyte and neuron apoptosis, faster apoptotic cristae remodeling and cytochrome c release from mitochondria, dyspnea, cryptorchism, reduced testes and epididymi, kyphosis and premature death due to progressive cachexia sustained by multisystemic atrophy.|G|A|75|37.0|Non-synonymous|Unprocessed|APF-G1
1781746|IGL00821|7|6305397|N->D||0.15|Benign||deleterious|MGI:2442757|Zfp667|zinc finger protein 667 [Source:MGI Symbol;Acc:MGI:2442757]|Heterozygous||A|G|73|39.0|Non-synonymous|Unprocessed|APF-G1
1781747|IGL00821|5|110204933|H->N||0.48|Possibly damaging|0.86|tolerated|MGI:96958|Golga3|golgi autoantigen, golgin subfamily a, 3 [Source:MGI Symbol;Acc:MGI:96958]|Heterozygous|Males homozygous for a hypomorphic transgenic insertional mutation exhibit impaired spermatogenesis involving loss of pachytene spermatocytes and are usually sterile.|C|A|65|37.0|Non-synonymous|Unprocessed|APF-G1
1781748|IGL00821|14|99091486|I->V|||Benign|0.42|tolerated|MGI:1919912|Dis3|DIS3 mitotic control homolog (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1919912]|Heterozygous||T|C|58|40.0|Non-synonymous|Unprocessed|APF-G1
1781749|IGL00821|9|123570549|Q->L||0.52|Possibly damaging|0.08|tolerated|MGI:1933169|Sacm1l|SAC1 (suppressor of actin mutations 1, homolog)-like (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1933169]|Heterozygous||A|T|56|40.0|Non-synonymous|Unprocessed|APF-G1
1781750|IGL00821|17|71398623|T->A||0.99|Probably damaging|0.12|tolerated|MGI:1921605|Smchd1|SMC hinge domain containing 1 [Source:MGI Symbol;Acc:MGI:1921605]|Heterozygous||T|C|55|39.0|Non-synonymous|Unprocessed|APF-G1
1781751|IGL00821|15|102299813|L->P||1.0|Probably damaging|0.01|deleterious|MGI:2146156|Espl1|extra spindle poles-like 1 (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:2146156]|Heterozygous|Homozygous null mice display embryonic lethality before somite formation. Conditional null mice display abnormal mitosis during liver regeneration.|T|C|52|38.5|Non-synonymous|Unprocessed|APF-G1
1781752|IGL00821|4|150619463|K->E||0.97|Probably damaging||deleterious|MGI:2683486|Rere|arginine glutamic acid dipeptide (RE) repeats [Source:MGI Symbol;Acc:MGI:2683486]|Heterozygous||A|G|52|39.0|Non-synonymous|Unprocessed|APF-G1
1781754|IGL00821|1|155862204|V->A|||Benign|1.0|tolerated|MGI:1921331|Cep350|centrosomal protein 350 [Source:MGI Symbol;Acc:MGI:1921331]|Heterozygous||A|G|43|37.0|Non-synonymous|Unprocessed|APF-G1
1781755|IGL00821|16|32369398|D->N||0.56|Possibly damaging|0.01|deleterious|MGI:2146388|Ubxn7|UBX domain protein 7 [Source:MGI Symbol;Acc:MGI:2146388]|Heterozygous||G|A|43|39.0|Non-synonymous|Unprocessed|APF-G1
1781756|IGL00821|6|30564412|D->G||0.02|Benign|0.12|tolerated|MGI:3617840|Cpa2|carboxypeptidase A2, pancreatic [Source:MGI Symbol;Acc:MGI:3617840]|Heterozygous||A|G|34|38.0|Non-synonymous|Unprocessed|APF-G1
1781757|IGL00821|11|100260631|L->P||1.0|Probably damaging||deleterious|MGI:96691|Krt17|keratin 17 [Source:MGI Symbol;Acc:MGI:96691]|Heterozygous|Mice homozygous for a knock-out allele display age- and strain-dependent alopecia associated with frequent absence of vibrissae, increased hair fragility, abnormal hair cycling, altered hair follicle morphology, and apoptosis in matrix cells.|A|G|32|38.5|Non-synonymous|Unprocessed|APF-G1
1781758|IGL00821|5|65372149|Y->F||1.0|Probably damaging||deleterious|MGI:1932466|Klb|klotho beta [Source:MGI Symbol;Acc:MGI:1932466]|Heterozygous|Homozygous null mice display increased bile acid synthesis and excretion, resistance to gallstone formation, and slightly decreased body weight.|A|T|31|35.0|Non-synonymous|Unprocessed|APF-G1
1781759|IGL00821|9|98992165|G->R||1.0|Probably damaging|0.15|tolerated|MGI:1344387|Faim|Fas apoptotic inhibitory molecule [Source:MGI Symbol;Acc:MGI:1344387]|Heterozygous|Mice homozygous for a null allele have thymocytes with an enhanced susceptibility to FAS-induced apoptosis, and B cells that more susceptible to activation induced cell death.|G|A|31|37.0|Non-synonymous|Unprocessed|APF-G1
1781760|IGL00821|7|30570613|L->Q||1.0|Probably damaging||deleterious|MGI:109565|Wbp7|WW domain binding protein 7 [Source:MGI Symbol;Acc:MGI:109565]|Heterozygous||A|T|24|39.5|Non-synonymous|Unprocessed|APF-G1
1781761|IGL00821|11|73123148|D->E||1.0|Probably damaging|0.01|deleterious|MGI:1298377|Itgae|integrin alpha E, epithelial-associated [Source:MGI Symbol;Acc:MGI:1298377]|Heterozygous|Homozygotes for a targeted null mutation exhibit reductions in the numbers of intestinal and vaginal intraepithelial lymphocytes and of T lymphocytes of the lamina propria.|T|A|22|37.5|Non-synonymous|Unprocessed|APF-G1
1781762|IGL00821|2|69459516|N->Y||0.55|Possibly damaging||deleterious|MGI:95794|Lrp2|low density lipoprotein receptor-related protein 2 [Source:MGI Symbol;Acc:MGI:95794]|Heterozygous|Homozygotes for a targeted null mutation exhibit lung and kidney epithelial defects, impaired B12 uptake, reduced proliferation of the neuroepithelium resulting in lack of olfactory bulbs, forebrain fusions, ventricular defects, and perinatal lethality.|T|A|21|37.0|Non-synonymous|Unprocessed|APF-G1
1781763|IGL00821|5|31061484|Y->H||1.0|Probably damaging||deleterious|MGI:88242|Cad|carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase [Source:MGI Symbol;Acc:MGI:1916969]|Heterozygous||T|C|19|37.0|Non-synonymous|Unprocessed|APF-G1
1781764|IGL00821|8|13028802|T->A||0.39|Benign|0.05|deleterious|MGI:109325|F7|coagulation factor VII [Source:MGI Symbol;Acc:MGI:109325]|Heterozygous|Mice homozygous for a targeted null mutation developed normally through embryogenesis, and exhibited no vascular defects; however, 70% of homozygous neonates suffered fatal intra-abdominal haemorrhaging and died within 24 hours after birth.|A|G|18|36.5|Non-synonymous|Unprocessed|APF-G1
1781766|IGL00821|15|41103387|N->K||1.0|Probably damaging|0.01|deleterious|MGI:1334444|Zfpm2|zinc finger protein, multitype 2 [Source:MGI Symbol;Acc:MGI:1334444]|Heterozygous|Homozygotes for targeted null mutations exhibit cardiac defects, including absence of coronary vasculature, resulting in lethality between E12.5 and E15.5. Conditional mutations reveal errors in ovary and testis development.|T|A|14|38.0|Non-synonymous|Unprocessed|APF-G1
1781767|IGL00821|8|109555654|I->V|||Benign|0.99|tolerated|MGI:1927617|Dhx38|DEAH (Asp-Glu-Ala-His) box polypeptide 38 [Source:MGI Symbol;Acc:MGI:1927617]|Heterozygous||T|C|14|37.0|Non-synonymous|Unprocessed|APF-G1
1781768|IGL00821|15|99316501|E->G|||Unknown||deleterious|MGI:1925583|Prpf40b|PRP40 pre-mRNA processing factor 40 homolog B (yeast) [Source:MGI Symbol;Acc:MGI:1925583]|Heterozygous||A|G|12|35.0|Non-synonymous|Unprocessed|APF-G1
1781769|IGL00821|7|107729876|F->V||1.0|Probably damaging||deleterious|MGI:894649|Ppfibp2|PTPRF interacting protein, binding protein 2 (liprin beta 2) [Source:MGI Symbol;Acc:MGI:894649]|Heterozygous||T|G|10|37.0|Non-synonymous|Unprocessed|APF-G1
1781771|IGL00821|12|59170320|Disrupted splicing||||||MGI:1346056|Ctage5|CTAGE family, member 5 [Source:MGI Symbol;Acc:MGI:1346056]|Heterozygous||T|C|38|38.0|Splice|Unprocessed|APF-G1
1781772|IGL00821|11|67197397|Disrupted splicing||||||MGI:1339710|Myh2|myosin, heavy polypeptide 2, skeletal muscle, adult [Source:MGI Symbol;Acc:MGI:1339710]|Heterozygous||C|T|30|39.0|Splice|Unprocessed|APF-G1
1781773|IGL00821|10|83313530|Disrupted splicing||||||MGI:2442940|Slc41a2|solute carrier family 41, member 2 [Source:MGI Symbol;Acc:MGI:2442940]|Heterozygous||A|G|24|39.0|Splice|Unprocessed|APF-G1
1781774|IGL00821|13|78198114|Disrupted splicing||||||MGI:1352451|Nr2f1|nuclear receptor subfamily 2, group F, member 1 [Source:MGI Symbol;Acc:MGI:1352451]|Heterozygous|Mice homozygous for a targeted mutation die perinatally displaying abnormal morphogenesis of the glossopharyngeal ganglion and nerve, abnormal regionalization of the neocortex, as well as defective nerve projection and reduced arborization in a subset of neurons in the peripheral nervous system.|A|G|21|36.0|Splice|Unprocessed|APF-G1
1781775|IGL00821|12|110865007|Disrupted splicing||||||MGI:1920055|Zfp839|zinc finger protein 839 [Source:MGI Symbol;Acc:MGI:1920055]|Heterozygous||T|C|13|40.0|Splice|Unprocessed|APF-G1
1782278|IGL00822|17|75151321|Y->C||0.99|Probably damaging|0.17|tolerated|MGI:109151|Ltbp1|latent transforming growth factor beta binding protein 1 [Source:MGI Symbol;Acc:MGI:109151]|Heterozygous|Mice homozygous for a null allele exhibit embryonic and neonatal lethality associated with defects in the aortic arch and outflow tract.|A|G|76|34.0|Non-synonymous|Unprocessed|APF-G1
1782279|IGL00822|11|20094367|R->W||1.0|Probably damaging|0.01|deleterious|MGI:1913963|Actr2|ARP2 actin-related protein 2 homolog (yeast) [Source:MGI Symbol;Acc:MGI:1913963]|Heterozygous||G|A|67|38.0|Non-synonymous|Unprocessed|APF-G1
1782280|IGL00822|17|32470832|N->S|||Benign|0.45|tolerated|MGI:2445210|Cyp4f39|cytochrome P450, family 4, subfamily f, polypeptide 39 [Source:MGI Symbol;Acc:MGI:2445210]|Heterozygous||A|G|57|39.0|Non-synonymous|Unprocessed|APF-G1
1782281|IGL00822|19|25188409|E->Stop|||N/A|||MGI:1921396|Dock8|dedicator of cytokinesis 8 [Source:MGI Symbol;Acc:MGI:1921396]|Heterozygous|Mice homozygous for inactivating mutations of this gene exhibit loss of marginal zone B cells, decrease in peritoneal B1 cells and peripheral naive T cells, failure of sustained antibody response after immunization, failure of germinal center persistence, and failure of B cell affinity maturation.|G|T|56|38.0|Non-synonymous|Unprocessed|APF-G1
1782282|IGL00822|5|8950046|F->L||0.11|Benign|0.11|tolerated|MGI:97569|Abcb4|ATP-binding cassette, sub-family B (MDR/TAP), member 4 [Source:MGI Symbol;Acc:MGI:97569]|Heterozygous|Mice homozygous for targeted mutations that inactivate the gene are unable to secrete phospholipids into bile, leading to progressive hepatic disease, with an end stage of 3 months.|T|C|53|39.0|Non-synonymous|Unprocessed|APF-G1
1782283|IGL00822|18|7181817|L->M||0.99|Probably damaging|0.01|deleterious|MGI:1922184|Armc4|armadillo repeat containing 4 [Source:MGI Symbol;Acc:MGI:1922184]|Heterozygous||A|T|48|40.0|Non-synonymous|Unprocessed|APF-G1
1782284|IGL00822|9|45125544|V->M||1.0|Probably damaging|0.01|deleterious|MGI:106921|Scn2b|sodium channel, voltage-gated, type II, beta [Source:MGI Symbol;Acc:MGI:106921]|Heterozygous|Mice homozygous for a knock-out allele display decreased sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to pilocarpine-induced seizures but appear normal in other neurological tests.|G|A|45|38.0|Non-synonymous|Unprocessed|APF-G1
1782285|IGL00822|11|8443976|T->I||0.99|Probably damaging|0.29|tolerated|MGI:2443012|Tns3|tensin 3 [Source:MGI Symbol;Acc:MGI:2443012]|Heterozygous|Mice homozygous for a null allele exhibit one third postnatal lethality, reduced body weight, growth retardation, smaller digestive tracts with defects in villi and enterocyte differentiation, abnormal lung morphology, and thinner bones with decreased chondrocyte proliferation.|G|A|38|34.0|Non-synonymous|Unprocessed|APF-G1
1782286|IGL00822|16|17836634|M->K||1.0|Probably damaging||deleterious|MGI:1931324|Car15|carbonic anhydrase 15 [Source:MGI Symbol;Acc:MGI:1931324]|Heterozygous||A|T|38|38.5|Non-synonymous|Unprocessed|APF-G1
1782287|IGL00822|9|110766489|T->K||0.27|Benign||deleterious|MGI:97268|Myl3|myosin, light polypeptide 3 [Source:MGI Symbol;Acc:MGI:97268]|Heterozygous||C|A|31|37.0|Non-synonymous|Unprocessed|APF-G1
1782288|IGL00822|8|60535758|S->P||0.22|Benign|0.14|tolerated|MGI:1345167|Aadat|aminoadipate aminotransferase [Source:MGI Symbol;Acc:MGI:1345167]|Heterozygous|Homozygous null mice are viable and display earlier eye opening and development of air righting and open field crossing responses, and transient hyperactivity and neuronal abnormalities.|T|C|29|40.0|Non-synonymous|Unprocessed|APF-G1
1782289|IGL00822|6|131301662|K->E||0.45|Possibly damaging|0.04|deleterious|MGI:2141396|Styk1|serine/threonine/tyrosine kinase 1 [Source:MGI Symbol;Acc:MGI:2141396]|Heterozygous||T|C|25|40.0|Non-synonymous|Unprocessed|APF-G1
1782290|IGL00822|1|157564555|A->S|||Benign|0.53|tolerated|MGI:2148802|Sec16b|SEC16 homolog B (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:2148802]|Heterozygous||G|T|23|40.0|Non-synonymous|Unprocessed|APF-G1
1782291|IGL00822|19|5111513|V->E||1.0|Probably damaging||deleterious|MGI:107953|Klc2|kinesin light chain 2 [Source:MGI Symbol;Acc:MGI:107953]|Heterozygous||A|T|21|38.0|Non-synonymous|Unprocessed|APF-G1
1782292|IGL00822|6|54944946|Y->C||1.0|Probably damaging||deleterious|MGI:1341839|Nod1|nucleotide-binding oligomerization domain containing 1 [Source:MGI Symbol;Acc:MGI:1341839]|Heterozygous|Homozygous mutant mice were viable, fertile, and appeared normal in a specific-pathogen free environment.|T|C|19|37.0|Non-synonymous|Unprocessed|APF-G1
1782293|IGL00822|11|67361328|T->A||1.0|Probably damaging|0.31|tolerated|MGI:1339967|Myh13|myosin, heavy polypeptide 13, skeletal muscle [Source:MGI Symbol;Acc:MGI:1339967]|Heterozygous||A|G|18|36.5|Non-synonymous|Unprocessed|APF-G1
1782294|IGL00822|12|88455516|I->T||0.85|Possibly damaging||deleterious|MGI:1919363|Adck1|aarF domain containing kinase 1 [Source:MGI Symbol;Acc:MGI:1919363]|Heterozygous||T|C|17|40.0|Non-synonymous|Unprocessed|APF-G1
1782295|IGL00822|5|47989151|E->K||1.0|Probably damaging|0.03|deleterious|MGI:1315205|Slit2|slit homolog 2 (Drosophila) [Source:MGI Symbol;Acc:MGI:1315205]|Heterozygous|Homozygous mutants display perinatal lethality, abnormal ureteric bud development, multiple fused kidneys, multiple ureters, and hydroureter.|G|A|17|36.0|Non-synonymous|Unprocessed|APF-G1
1782296|IGL00822|5|105608308|A->S|||Benign|0.6|tolerated|MGI:2140839|Lrrc8c|leucine rich repeat containing 8 family, member C [Source:MGI Symbol;Acc:MGI:2140839]|Heterozygous||G|T|16|40.0|Non-synonymous|Unprocessed|APF-G1
1782297|IGL00822|2|120514160|R->C|||||deleterious|MGI:1270153|Zfp106|zinc finger protein 106 [Source:MGI Symbol;Acc:MGI:1270153]|Heterozygous||G|A|14|40.0|Non-synonymous|Unprocessed|APF-G1
1782298|IGL00822|4|154980602|R->H||0.79|Possibly damaging|0.03|deleterious|MGI:2387466|Pank4|pantothenate kinase 4 [Source:MGI Symbol;Acc:MGI:2387466]|Heterozygous||G|A|13|37.0|Non-synonymous|Unprocessed|APF-G1
1782299|IGL00822|7|102084368|I->V||0.99|Probably damaging|0.1|tolerated|MGI:109527|Trpc2|transient receptor potential cation channel, subfamily C, member 2 [Source:MGI Symbol;Acc:MGI:109527]|Heterozygous|Homozygous null mice exhibit altered sexual and social behavior, including intermale mounting and a lack of aggressive behavior in the presence of invading males. Homozygotes for another allele show increased triglyceride levels in both males and females and increased cholesterol in males.|A|G|13|37.0|Non-synonymous|Unprocessed|APF-G1
1782300|IGL00822|14|20737330|G->S|||Benign|0.26|tolerated|MGI:88259|Camk2g|calcium/calmodulin-dependent protein kinase II gamma [Source:MGI Symbol;Acc:MGI:88259]|Heterozygous|Mice homozygous for a knock-out allele exhibit female infertility and decreased sensitivity of macrophages to ER stress-induced apoptosis.|C|T|12|35.0|Non-synonymous|Unprocessed|APF-G1
1782301|IGL00822|3|158185474|V->A||0.97|Probably damaging|0.2|tolerated|MGI:2676665|Lrrc7|leucine rich repeat containing 7 [Source:MGI Symbol;Acc:MGI:2676665]|Heterozygous||A|G|10|38.5|Non-synonymous|Unprocessed|APF-G1
1782302|IGL00822|7|46295880|S->N||0.44|Possibly damaging|0.06|tolerated|MGI:1202064|Otog|otogelin [Source:MGI Symbol;Acc:MGI:1202064]|Heterozygous|Homozygotes for a number of different spontaneous and targeted mutations exhibit vestibular dysfunction, including circling, head tilt, impaired balance, coordination, and placing response. Mutants have impaired hearing, decreased brain stem auditory evoked potential, and ear abnormalities.|G|A|10|36.0|Non-synonymous|Unprocessed|APF-G1
1782307|IGL00822|15|98528853|Disrupted splicing||||||MGI:1916862|2310037i24rik|RIKEN cDNA 2310037I24 gene [Source:MGI Symbol;Acc:MGI:1916862]|Heterozygous||T|C|56|40.0|Splice|Unprocessed|APF-G1
1782308|IGL00822|1|87845026|Disrupted splicing||||||MGI:98227|Sag|retinal S-antigen [Source:MGI Symbol;Acc:MGI:98227]|Heterozygous||A|G|15|40.0|Splice|Unprocessed|APF-G1
1782309|IGL00822|11|72499353|Disrupted splicing||||||MGI:1924827|Spns3|spinster homolog 3 (Drosophila) [Source:MGI Symbol;Acc:MGI:1924827]|Heterozygous||A|T|10|33.0|Splice|Unprocessed|APF-G1
1782807|IGL00823|8|92864970|W->G||1.0|Probably damaging||deleterious|MGI:3606214|Lpcat2|lysophosphatidylcholine acyltransferase 2 [Source:MGI Symbol;Acc:MGI:3606214]|Heterozygous||T|G|302|39.0|Non-synonymous|Unprocessed|APF-G1
1782808|IGL00823|11|21659995|D->G||1.0|Probably damaging|0.01|deleterious|MGI:2144467|Wdpcp|WD repeat containing planar cell polarity effector [Source:MGI Symbol;Acc:MGI:2144467]|Heterozygous||A|G|115|39.0|Non-synonymous|Unprocessed|APF-G1
1782809|IGL00823|2|76709713|T->A|||Unknown|||MGI:98864|Ttn|titin [Source:MGI Symbol;Acc:MGI:98864]|Heterozygous|Homozygous mutant mice show embryogenesis defects in frontonasal mass, first branchial arch and somites, and vascular, cardiac and skeletal muscle defects causing growth retardation, muscle weakness, abnormal posture, and premature death ranging from embryonic day 11.5 to 8 weeks of age.|T|C|106|39.0|Non-synonymous|Unprocessed|APF-G1
1782810|IGL00823|7|131058158|W->R|||Unknown|0.55|tolerated|MGI:106210|Dmbt1|deleted in malignant brain tumors 1 [Source:MGI Symbol;Acc:MGI:106210]|Heterozygous|Mice homozygous for one null allele display embryonic lethality and an abnormal inner cell mass.  Mice homozygous for a different null allele are viable and fertile with an increased susceptibility to induced colitis.|T|C|103|38.0|Non-synonymous|Unprocessed|APF-G1
1782811|IGL00823|2|31918521|D->V||1.0|Probably damaging||deleterious|MGI:1344394|Lamc3|laminin gamma 3 [Source:MGI Symbol;Acc:MGI:1344394]|Heterozygous||A|T|99|38.0|Non-synonymous|Unprocessed|APF-G1
1782812|IGL00823|10|87570331|Y->C||1.0|Probably damaging||deleterious|MGI:97473|Pah|phenylalanine hydroxylase [Source:MGI Symbol;Acc:MGI:97473]|Heterozygous||A|G|95|36.0|Non-synonymous|Unprocessed|APF-G1
1782813|IGL00823|2|144255565|I->V|||Benign|1.0|tolerated|MGI:1916428|Snx5|sorting nexin 5 [Source:MGI Symbol;Acc:MGI:1916428]|Heterozygous||T|C|83|39.0|Non-synonymous|Unprocessed|APF-G1
1782814|IGL00823|10|63537543|P->L||0.96|Probably damaging|0.29|tolerated|MGI:2661445|Ctnna3|catenin (cadherin associated protein), alpha 3 [Source:MGI Symbol;Acc:MGI:2661445]|Heterozygous||C|T|81|38.0|Non-synonymous|Unprocessed|APF-G1
1782815|IGL00823|X|157568211|D->E|||Benign|1.0|tolerated|MGI:2444506, MGI:3837947|Yy2,mbtps2|Yy2 transcription factor [Source:MGI Symbol;Acc:MGI:3837947],membrane-bound transcription factor peptidase, site 2 [Source:MGI Symbol;Acc:MGI:2444506]|Heterozygous||A|C|78|39.0|Non-synonymous|Unprocessed|APF-G1
1782816|IGL00823|12|70014793|N->S||0.16|Benign|0.2|tolerated|MGI:105108|Nin|ninein [Source:MGI Symbol;Acc:MGI:105108]|Heterozygous||T|C|75|37.0|Non-synonymous|Unprocessed|APF-G1
1782817|IGL00823|8|24818742|E->G||0.01|Benign|0.29|tolerated|MGI:104730|Adam5|a disintegrin and metallopeptidase domain 5 [Source:MGI Symbol;Acc:MGI:104730]|Heterozygous||T|C|70|40.0|Non-synonymous|Unprocessed|APF-G1
1782818|IGL00823|12|52518742|T->I||1.0|Probably damaging|0.8|tolerated|MGI:1332637|Arhgap5|Rho GTPase activating protein 5 [Source:MGI Symbol;Acc:MGI:1332637]|Heterozygous|Homozygotes die at birth, are 30% smaller, do not inflate their lungs, and show a small thymus, abnormal adipocyte differentiation and brain defects in the corpus callosum, anterior commissure and lateral ventricles. Mutant MEFs show impaired adipogenesis but undergo myogenesis in response to IGF-1.|C|T|65|38.0|Non-synonymous|Unprocessed|APF-G1
1782819|IGL00823|1|188911443|C->Y|||Benign|0.03|deleterious|MGI:1341292|Ush2a|Usher syndrome 2A (autosomal recessive, mild) homolog (human) [Source:MGI Symbol;Acc:MGI:1341292]|Heterozygous|Mice homozygous for a knock-out allele display progressive retinal photoreceptor degeneration along with significantly reduced a- and b-wave amplitudes, and a moderate but nonprogressive high-frequency hearing loss associated with widespread loss of outer hair cells in the basal turn of the cochlea.|G|A|63|37.0|Non-synonymous|Unprocessed|APF-G1
1782820|IGL00823|1|132489706|V->I||0.28|Benign|0.17|tolerated|MGI:1918367|Rbbp5|retinoblastoma binding protein 5 [Source:MGI Symbol;Acc:MGI:1918367]|Heterozygous||G|A|59|38.0|Non-synonymous|Unprocessed|APF-G1
1782821|IGL00823|17|74447990|D->G|||Benign|0.12|tolerated|MGI:3036243|Nlrc4|NLR family, CARD domain containing 4 [Source:MGI Symbol;Acc:MGI:3036243]|Heterozygous||T|C|59|39.0|Non-synonymous|Unprocessed|APF-G1
1782822|IGL00823|4|151084601|I->R||0.03|Benign|0.54|tolerated|MGI:2140230|Camta1|calmodulin binding transcription activator 1 [Source:MGI Symbol;Acc:MGI:2140230]|Heterozygous||A|C|51|35.0|Non-synonymous|Unprocessed|APF-G1
1782823|IGL00823|X|53245331|C->S|||||deleterious|MGI:1926005|Fam122b|family with sequence similarity 122, member B [Source:MGI Symbol;Acc:MGI:1926005]|Heterozygous||A|T|50|38.5|Non-synonymous|Unprocessed|APF-G1
1782824|IGL00823|10|44363044|T->A|||Benign|0.27|tolerated|MGI:1277186|Atg5|autophagy-related 5 (yeast) [Source:MGI Symbol;Acc:MGI:1277186]|Heterozygous|Mutation of this gene results in impaired autophagy due to absence of autolysosomes. Homozygotes die within 1 day of birth, have shorter survival times and reduced amino acid levels under fasting conditions. Homozygotes for a gene trap insertion mutation in this gene show no abnormal phenotype.|A|G|48|39.0|Non-synonymous|Unprocessed|APF-G1
1782825|IGL00823|6|91988459|S->T||0.27|Benign|0.53|tolerated|MGI:2443369|Fgd5|FYVE, RhoGEF and PH domain containing 5 [Source:MGI Symbol;Acc:MGI:2443369]|Heterozygous||T|A|45|39.0|Non-synonymous|Unprocessed|APF-G1
1782826|IGL00823|5|121665227|M->K||0.98|Probably damaging|0.01|deleterious|MGI:1919649|Brap|BRCA1 associated protein [Source:MGI Symbol;Acc:MGI:1919649]|Heterozygous||T|A|44|39.0|Non-synonymous|Unprocessed|APF-G1
1782827|IGL00823|8|13457054|M->T|||Benign|0.58|tolerated|MGI:2685533|Fam70b|family with sequence similarity 70, member B [Source:MGI Symbol;Acc:MGI:2685533]|Heterozygous||T|C|39|38.0|Non-synonymous|Unprocessed|APF-G1
1782828|IGL00823|9|37320413|G->D|||Benign|0.12|tolerated|MGI:2444488|Ccdc15|coiled-coil domain containing 15 [Source:MGI Symbol;Acc:MGI:2444488]|Heterozygous||C|T|29|38.0|Non-synonymous|Unprocessed|APF-G1
1782829|IGL00823|11|118047161|V->I||0.07|Benign|0.61|tolerated|MGI:1917176|Dnahc17|dynein, axonemal, heavy chain 17 [Source:MGI Symbol;Acc:MGI:1917176]|Heterozygous||C|T|28|37.0|Non-synonymous|Unprocessed|APF-G1
1782830|IGL00823|4|11783412|S->R||0.85|Possibly damaging|0.04|deleterious|MGI:1095414|Cdh17|cadherin 17 [Source:MGI Symbol;Acc:MGI:1095414]|Heterozygous|Homozygous mutant mice exhibit impaired B lymphocyte development and impaired IgG1 and IgG3 antibody response to T-independent antigen.|T|G|28|35.0|Non-synonymous|Unprocessed|APF-G1
1782831|IGL00823|11|79565517|D->G||0.99|Probably damaging|0.03|deleterious|MGI:97306|Nf1|neurofibromatosis 1 [Source:MGI Symbol;Acc:MGI:97306]|Heterozygous|Homozygous embryos die by day 14.5 with enlarged head and chest, pale liver, microphthalmia, cardiac defects and delayed organ development. Heterozygotes have elevated astrocyte number, predisposition to multiple tumor types and learning/memory deficits.|A|G|27|37.0|Non-synonymous|Unprocessed|APF-G1
1782832|IGL00823|2|66324935|R->H||0.32|Benign|0.35|tolerated|MGI:98246|Scn1a|sodium channel, voltage-gated, type I, alpha [Source:MGI Symbol;Acc:MGI:98246]|Heterozygous|Mice homozygous for a knock-out allele exhibit postnatal lethality, seizures, and abnormal behavior. Mice heterozygous for a knock-out allele exhibit premature death and seizures associated with abnormal nervous system electrophysiology.|C|T|26|37.0|Non-synonymous|Unprocessed|APF-G1
1782833|IGL00823|13|93186397|T->A|||Benign|0.23|tolerated|MGI:2140950|Papd4|PAP associated domain containing 4 [Source:MGI Symbol;Acc:MGI:2140950]|Heterozygous|Mice homozygous for a null allele reuslts in disruption in polyadenylation in oocytes and somatic cells.|T|C|25|39.0|Non-synonymous|Unprocessed|APF-G1
1782834|IGL00823|12|75989242|S->P||0.95|Possibly damaging|0.01|deleterious|MGI:2449316|Syne2|synaptic nuclear envelope 2 [Source:MGI Symbol;Acc:MGI:2449316]|Heterozygous|Homozygotes for one knock-out allele show normal myonuclear positioning of both synaptic and non-synaptic nuclei in skeletal muscle cells. Homozygotes for another knock-out allele exhibit a thickened epidermis and altered nuclear envelope architecture in primary dermal fibroblasts and keratinocytes.|T|C|22|38.0|Non-synonymous|Unprocessed|APF-G1
1782835|IGL00823|5|122433477|W->Stop|||N/A|||MGI:1929711|Anapc7|anaphase promoting complex subunit 7 [Source:MGI Symbol;Acc:MGI:1929711]|Heterozygous||G|A|20|37.5|Non-synonymous|Unprocessed|APF-G1
1782836|IGL00823|11|67355947|I->V|||Benign|0.17|tolerated|MGI:1339967|Myh13|myosin, heavy polypeptide 13, skeletal muscle [Source:MGI Symbol;Acc:MGI:1339967]|Heterozygous||A|G|19|37.0|Non-synonymous|Unprocessed|APF-G1
1782837|IGL00823|16|16887622|I->T||0.98|Probably damaging||deleterious|MGI:1333803|Top3b|topoisomerase (DNA) III beta [Source:MGI Symbol;Acc:MGI:1333803]|Heterozygous|Homozygous null mice develop to maturity but die prematurely showing enlargement of lymphatic organs and glomerulonephritis. Intercrossing of mutant mice progressively results in infertility that is correlated to increased aneuploidy in germ cells.|T|C|17|38.0|Non-synonymous|Unprocessed|APF-G1
1782838|IGL00823|3|94767209|R->W||1.0|Probably damaging||deleterious|MGI:1927237|Cgn|cingulin [Source:MGI Symbol;Acc:MGI:1927237]|Heterozygous||G|A|11|40.0|Non-synonymous|Unprocessed|APF-G1
1782839|IGL00823|6|113321886|S->P|||Benign|0.31|tolerated|MGI:1926033|Brpf1|bromodomain and PHD finger containing, 1 [Source:MGI Symbol;Acc:MGI:1926033]|Heterozygous||T|C|10|37.0|Non-synonymous|Unprocessed|APF-G1
1782841|IGL00823|3|102758233|Disrupted splicing||||||MGI:1917997|Tspan2|tetraspanin 2 [Source:MGI Symbol;Acc:MGI:1917997]|Heterozygous||T|C|157|38.0|Splice|Unprocessed|APF-G1
1782842|IGL00823|12|102398176|Disrupted splicing||||||MGI:1330838|Lgmn|legumain [Source:MGI Symbol;Acc:MGI:1330838]|Heterozygous|While homozygous mutant mice appear normal at birth, they exhibit reduced weight gain later in life.|T|C|48|37.0|Splice|Unprocessed|APF-G1
1782843|IGL00823|8|14940378|Disrupted splicing||||||MGI:2444453|Arhgef10|Rho guanine nucleotide exchange factor (GEF) 10 [Source:MGI Symbol;Acc:MGI:2444453]|Heterozygous||T|A|42|38.0|Splice|Unprocessed|APF-G1
1782844|IGL00823|5|76878534|Disrupted splicing||||||MGI:2442517|Aasdh|aminoadipate-semialdehyde dehydrogenase [Source:MGI Symbol;Acc:MGI:2442517]|Heterozygous||T|C|41|38.0|Splice|Unprocessed|APF-G1
1782845|IGL00823|10|100087344|Disrupted splicing||||||MGI:96974|Kitl|kit ligand [Source:MGI Symbol;Acc:MGI:96974]|Heterozygous|Mutations in this gene affect migration of embryonic stem cells and cause similar phenotypes to mutations in its receptor gene (Kit). Mutants show mild to severe defects in pigmentation, hemopoiesis and reproduction.|C|A|40|39.5|Splice|Unprocessed|APF-G1
1782846|IGL00823|X|84425813|Disrupted splicing||||||MGI:94909|Dmd|dystrophin, muscular dystrophy [Source:MGI Symbol;Acc:MGI:94909]|Heterozygous|Hemizygous males and homozygous mutant females show progressive muscle atrophy, increased K+ and Ca+ in muscle with age, increased blood pyruvate kinase and other symptoms of Duchenne and Becker muscular dystrophy. Alleles vary in severity and may include cardiovascular and digestive system defects.|A|G|26|39.0|Splice|Unprocessed|APF-G1
1782847|IGL00823|19|10796394|Disrupted splicing||||||MGI:103566|Cd6|CD6 antigen [Source:MGI Symbol;Acc:MGI:103566]|Heterozygous||G|T|19|41.0|Splice|Unprocessed|APF-G1
1782848|IGL00823|19|7204051|Disrupted splicing||||||MGI:2147616|Otub1|OTU domain, ubiquitin aldehyde binding 1 [Source:MGI Symbol;Acc:MGI:2147616]|Heterozygous||A|G|18|35.0|Splice|Unprocessed|APF-G1
1782849|IGL00823|15|79284565|Disrupted splicing||||||MGI:2652819|Baiap2l2|BAI1-associated protein 2-like 2 [Source:MGI Symbol;Acc:MGI:2652819]|Heterozygous||G|T|16|36.5|Splice|Unprocessed|APF-G1
1783365|IGL00824|6|85817297|L->R||1.0|Probably damaging||deleterious|MGI:1916299|Cml5|camello-like 5 [Source:MGI Symbol;Acc:MGI:1916299]|Heterozygous||A|C|100|40.0|Non-synonymous|Unprocessed|APF-G1
1783366|IGL00824|1|26683589|I->V||0.79|Possibly damaging|0.51|tolerated|MGI:3588222|4931408c20rik|RIKEN cDNA 4931408C20 gene [Source:MGI Symbol;Acc:MGI:3588222]|Heterozygous||T|C|83|38.0|Non-synonymous|Unprocessed|APF-G1
1783367|IGL00824|3|83068335|T->I||1.0|Probably damaging||deleterious|MGI:1858197|Plrg1|pleiotropic regulator 1, PRL1 homolog (Arabidopsis) [Source:MGI Symbol;Acc:MGI:1858197]|Heterozygous|Mice homozygous for a knock-out allele exhibit embryonic lethality by E1.5.|C|T|75|39.0|Non-synonymous|Unprocessed|APF-G1
1783368|IGL00824|3|95009185|L->P||1.0|Probably damaging||deleterious|MGI:1925516|Zfp687|zinc finger protein 687 [Source:MGI Symbol;Acc:MGI:1925516]|Heterozygous||A|G|64|38.0|Non-synonymous|Unprocessed|APF-G1
1783369|IGL00824|3|51682578|P->S||0.02|Benign|0.41|tolerated|MGI:2448481|Mgst2|microsomal glutathione S-transferase 2 [Source:MGI Symbol;Acc:MGI:2448481]|Heterozygous||C|T|61|38.0|Non-synonymous|Unprocessed|APF-G1
1783370|IGL00824|4|96663923|F->L|||Benign|1.0|tolerated|MGI:1270149|Cyp2j5|cytochrome P450, family 2, subfamily j, polypeptide 5 [Source:MGI Symbol;Acc:MGI:1270149]|Heterozygous|Female mice homozygous for a null mutation display increased systolic blood pressure, increased left ventricular weight, decreased litter sizes, decreased serum estrogen levels, and increased induced vasoconstriction responses.|A|G|61|36.0|Non-synonymous|Unprocessed|APF-G1
1783371|IGL00824|2|11683099|V->A||0.76|Possibly damaging|0.01|deleterious|MGI:96549|Il2ra|interleukin 2 receptor, alpha chain [Source:MGI Symbol;Acc:MGI:96549]|Heterozygous|Homozygotes for a targeted null mutation exhibit massive proliferation of polyclonal T and B cells as adults and develop autoimmune disorders including inflammatory bowel disease and hemolytic anemia with age.|T|C|54|38.0|Non-synonymous|Unprocessed|APF-G1
1783372|IGL00824|4|134506967|Y->C||1.0|Probably damaging||deleterious|MGI:1919154|Paqr7|progestin and adipoQ receptor family member VII [Source:MGI Symbol;Acc:MGI:1919154]|Heterozygous||A|G|38|37.0|Non-synonymous|Unprocessed|APF-G1
1783373|IGL00824|2|180150267|V->M||0.98|Probably damaging|0.64|tolerated|MGI:2442832|Osbpl2|oxysterol binding protein-like 2 [Source:MGI Symbol;Acc:MGI:2442832]|Heterozygous||G|A|37|39.0|Non-synonymous|Unprocessed|APF-G1
1783374|IGL00824|12|69932238|T->A||1.0|Probably damaging|0.01|deleterious|MGI:1921241|Atl1|atlastin GTPase 1 [Source:MGI Symbol;Acc:MGI:1921241]|Heterozygous||A|G|33|39.0|Non-synonymous|Unprocessed|APF-G1
1783375|IGL00824|8|13292825|V->E||1.0|Probably damaging||deleterious|MGI:2444946|Tmco3|transmembrane and coiled-coil domains 3 [Source:MGI Symbol;Acc:MGI:2444946]|Heterozygous||T|A|28|35.0|Non-synonymous|Unprocessed|APF-G1
1783376|IGL00824|X|134267405|I->M||0.42|Benign|0.08|tolerated|MGI:2442530|Trmt2b|TRM2 tRNA methyltransferase 2 homolog B (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:2442530]|Heterozygous||T|C|22|37.5|Non-synonymous|Unprocessed|APF-G1
1783377|IGL00824|1|150656734|V->E|||Benign|0.03|deleterious|MGI:2685047|Hmcn1|hemicentin 1 [Source:MGI Symbol;Acc:MGI:2685047]|Heterozygous||A|T|21|39.0|Non-synonymous|Unprocessed|APF-G1
1783378|IGL00824|7|42267014|N->K||0.02|Benign|0.45|tolerated|MGI:1351347|Vmn2r61|vomeronasal 2, receptor 61 [Source:MGI Symbol;Acc:MGI:1351347]|Heterozygous||T|A|21|38.0|Non-synonymous|Unprocessed|APF-G1
1783379|IGL00824|4|11784675|K->R||0.02|Benign|0.97|tolerated|MGI:1095414|Cdh17|cadherin 17 [Source:MGI Symbol;Acc:MGI:1095414]|Heterozygous|Homozygous mutant mice exhibit impaired B lymphocyte development and impaired IgG1 and IgG3 antibody response to T-independent antigen.|A|G|15|37.0|Non-synonymous|Unprocessed|APF-G1
1783380|IGL00824|12|83770436|S->G||0.43|Benign|0.1|tolerated|MGI:2386139|Papln|papilin, proteoglycan-like sulfated glycoprotein [Source:MGI Symbol;Acc:MGI:2386139]|Heterozygous||A|G|13|36.0|Non-synonymous|Unprocessed|APF-G1
1783381|IGL00824|10|116849359|Disrupted splicing||||||MGI:2685085|Gm239|predicted gene 239 [Source:MGI Symbol;Acc:MGI:2685085]|Heterozygous||T|C|129|39.0|Splice|Unprocessed|APF-G1
1783382|IGL00824|12|32965506|Disrupted splicing||||||MGI:108081|Sypl|synaptophysin-like protein [Source:MGI Symbol;Acc:MGI:108081]|Heterozygous||T|A|123|39.0|Splice|Unprocessed|APF-G1
1783383|IGL00824|1|20081184|Disrupted splicing||||||MGI:2155808|Pkhd1|polycystic kidney and hepatic disease 1 [Source:MGI Symbol;Acc:MGI:2155808]|Heterozygous|Mice homozygous for a mutation in this gene display variable progressive liver cysts and fibrosis, but do not display kidney cysts and are fertile.  Mice homozygous for a hypomorphic and null allele display renal, pancreatic, billiary and liver cysts.|A|G|31|37.0|Splice|Unprocessed|APF-G1
1783855|IGL00825|16|48928415|K->E||0.87|Possibly damaging|0.07|tolerated|MGI:1917433|Dzip3|DAZ interacting protein 3, zinc finger [Source:MGI Symbol;Acc:MGI:1917433]|Heterozygous||T|C|62|39.0|Non-synonymous|Unprocessed|APF-G1
1783856|IGL00825|1|58829006|S->N||0.11|Benign|0.51|tolerated|MGI:1261423|Casp8|caspase 8 [Source:MGI Symbol;Acc:MGI:1261423]|Heterozygous|Homozygotes for a targeted null mutation exhibit impaired cardiac muscle development, cardiac erythrocyte congestion, low numbers of colony-forming cells, and prenatal lethality. T-cell restricted knockout mice are viable, but immunodeficient.|G|A|50|38.0|Non-synonymous|Unprocessed|APF-G1
1783857|IGL00825|6|141542142|N->Y||1.0|Probably damaging||deleterious|MGI:1889679|Slco1c1|solute carrier organic anion transporter family, member 1c1 [Source:MGI Symbol;Acc:MGI:1889679]|Heterozygous||A|T|37|39.0|Non-synonymous|Unprocessed|APF-G1
1783858|IGL00825|19|46071406|R->S|||Unknown|||MGI:2385096|Pprc1|peroxisome proliferative activated receptor, gamma, coactivator-related 1 [Source:MGI Symbol;Acc:MGI:2385096]|Heterozygous||G|T|33|35.0|Non-synonymous|Unprocessed|APF-G1
1783859|IGL00825|3|138983827|I->F||0.92|Possibly damaging|0.68|tolerated|MGI:2385189|Rap1gds1|RAP1, GTP-GDP dissociation stimulator 1 [Source:MGI Symbol;Acc:MGI:2385189]|Heterozygous||T|A|32|37.5|Non-synonymous|Unprocessed|APF-G1
1783860|IGL00825|18|11722607|T->A|||Benign|1.0|tolerated|MGI:2442995|Rbbp8|retinoblastoma binding protein 8 [Source:MGI Symbol;Acc:MGI:2442995]|Heterozygous|Embryos homozygous for a knock-out allele die at E4.0 as blastocysts fail to enter S phase and arrest at G1, leading to elevated cell death. Heterozygous mutant mice display a shortened lifespan due to formation of multiple tumors, mostly large lymphomas of both B and T cells.|A|G|30|39.0|Non-synonymous|Unprocessed|APF-G1
1783861|IGL00825|18|10704657|V->M|||Benign|0.25|tolerated|MGI:2147183|Abhd3|abhydrolase domain containing 3 [Source:MGI Symbol;Acc:MGI:2147183]|Heterozygous||C|T|29|40.0|Non-synonymous|Unprocessed|APF-G1
1783862|IGL00825|7|128767609|L->I||1.0|Probably damaging|0.01|deleterious|MGI:2450915|Sec23ip|Sec23 interacting protein [Source:MGI Symbol;Acc:MGI:2450915]|Heterozygous|Male mice homozygous for a null allele display reduced fertility with globozoospermia and impaired fertilization.|C|A|29|40.0|Non-synonymous|Unprocessed|APF-G1
1783863|IGL00825|1|66801512|T->A|||Benign|0.57|tolerated|MGI:1915941|1110028c15rik|RIKEN cDNA 1110028C15 gene [Source:MGI Symbol;Acc:MGI:1915941]|Heterozygous||T|C|26|39.0|Non-synonymous|Unprocessed|APF-G1
1783864|IGL00825|1|46224651|Y->H||1.0|Probably damaging||deleterious|MGI:2684953|Dnahc7b|dynein, axonemal, heavy chain 7B [Source:MGI Symbol;Acc:MGI:2684953]|Heterozygous||T|C|24|39.0|Non-synonymous|Unprocessed|APF-G1
1783865|IGL00825|3|22189786|G->C||0.96|Probably damaging|0.21|tolerated|MGI:2441730|Tbl1xr1|transducin (beta)-like 1X-linked receptor 1 [Source:MGI Symbol;Acc:MGI:2441730]|Heterozygous||G|T|22|39.0|Non-synonymous|Unprocessed|APF-G1
1783866|IGL00825|8|71968044|C->S|||Benign|0.39|tolerated|MGI:3583954|Zfp961|zinc finger protein 961 [Source:MGI Symbol;Acc:MGI:3583954]|Heterozygous||T|A|22|39.0|Non-synonymous|Unprocessed|APF-G1
1783867|IGL00825|18|42645775|V->M||0.84|Possibly damaging|0.01|deleterious|MGI:1920180|Ppp2r2b|protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform [Source:MGI Symbol;Acc:MGI:1920180]|Heterozygous||C|T|20|39.0|Non-synonymous|Unprocessed|APF-G1
1783868|IGL00825|9|96570719|N->K||0.07|Benign|0.15|tolerated|MGI:2149960|Rasa2|RAS p21 protein activator 2 [Source:MGI Symbol;Acc:MGI:2149960]|Heterozygous||A|T|20|39.0|Non-synonymous|Unprocessed|APF-G1
1783869|IGL00825|11|70551180|W->Stop|||N/A|||MGI:892877|Pld2|phospholipase D2 [Source:MGI Symbol;Acc:MGI:892877]|Heterozygous|Mice homozygous for a targeted allele fail to exhibit Abeta42 suppression of LTP and altered brain phosphatidic acid levels.|G|A|19|33.0|Non-synonymous|Unprocessed|APF-G1
1783870|IGL00825|16|25992798|I->T||0.94|Possibly damaging|0.15|tolerated|MGI:2146663|Leprel1|leprecan-like 1 [Source:MGI Symbol;Acc:MGI:2146663]|Heterozygous||A|G|15|40.0|Non-synonymous|Unprocessed|APF-G1
1783871|IGL00825|9|56851691|I->T|||Benign|0.16|tolerated|MGI:2681875|Odf3l1|outer dense fiber of sperm tails 3-like 1 [Source:MGI Symbol;Acc:MGI:2681875]|Heterozygous||A|G|15|34.0|Non-synonymous|Unprocessed|APF-G1
1783872|IGL00825|10|81118218|V->I||0.13|Benign|1.0|tolerated|MGI:1346867|Map2k2|mitogen-activated protein kinase kinase 2 [Source:MGI Symbol;Acc:MGI:1346867]|Heterozygous|Homozygotes for a targeted null mutation are viable, fertile, and apparently normal.|G|A|14|33.5|Non-synonymous|Unprocessed|APF-G1
1783873|IGL00825|18|4673516|Y->F||0.18|Benign|0.05|tolerated|MGI:2685174|9430020k01rik|RIKEN cDNA 9430020K01 gene [Source:MGI Symbol;Acc:MGI:2685174]|Heterozygous||A|T|13|36.0|Non-synonymous|Unprocessed|APF-G1
1783874|IGL00825|11|106421967|K->R||0.83|Possibly damaging|0.31|tolerated|MGI:1930134|Ern1|endoplasmic reticulum (ER) to nucleus signalling 1 [Source:MGI Symbol;Acc:MGI:1930134]|Heterozygous|Mice homozygous for null mutations display embryonic lethality during organogenesis. Homozygous mice may also display decreased embryo size, impaired hematopoiesis, and/or placental abnormalities.|T|C|11|36.0|Non-synonymous|Unprocessed|APF-G1
1783875|IGL00825|19|8618357|V->A||0.58|Possibly damaging|0.01|deleterious|MGI:892001|Slc22a6|solute carrier family 22 (organic anion transporter), member 6 [Source:MGI Symbol;Acc:MGI:892001]|Heterozygous|Homozygous mutation of this gene may result in increased thymus weight or impaired renal organic anion excretion for a subset of organic anions.|T|C|10|39.0|Non-synonymous|Unprocessed|APF-G1
1783878|IGL00825|6|128980181|Disrupted splicing||||||MGI:1918059|Clec2g|C-type lectin domain family 2, member g [Source:MGI Symbol;Acc:MGI:1918059]|Heterozygous||C|A|68|39.0|Splice|Unprocessed|APF-G1
1783879|IGL00825|1|119659925|Disrupted splicing||||||MGI:1099792|Ptpn4|protein tyrosine phosphatase, non-receptor type 4 [Source:MGI Symbol;Acc:MGI:1099792]|Heterozygous|Mice homozygous for a null allele exhibit impaired coordination, abnormal eye blink conditioning behavior, and reduced long term depression.|A|G|44|38.0|Splice|Unprocessed|APF-G1
1783880|IGL00825|17|56571208|Disrupted splicing||||||MGI:2146808|Safb2|scaffold attachment factor B2 [Source:MGI Symbol;Acc:MGI:2146808]|Heterozygous||A|G|38|36.0|Splice|Unprocessed|APF-G1
1784345|IGL00826|11|83035259|Y->C||1.0|Probably damaging|||MGI:3512288|Slfn10-ps|schlafen 10, pseudogene [Source:MGI Symbol;Acc:MGI:3512288]|Heterozygous||T|C|67|39.0|Non-synonymous|Unprocessed|APF-G1
1784346|IGL00826|4|96585930|I->K||0.53|Possibly damaging||deleterious|MGI:1921769|Cyp2j9|cytochrome P450, family 2, subfamily j, polypeptide 9 [Source:MGI Symbol;Acc:MGI:1921769]|Heterozygous||A|T|64|40.0|Non-synonymous|Unprocessed|APF-G1
1784347|IGL00826|8|111040300|S->A||0.99|Probably damaging||deleterious|MGI:2384560|Aars|alanyl-tRNA synthetase [Source:MGI Symbol;Acc:MGI:2384560]|Heterozygous|Mice homozygous for a spontaneous point mutation have a rough, unkempt and sticky fur, display follicular dystrophy and patchy hair loss, develop tremors that progress to ataxia, and exhibit extensive loss of cerebellar Purkinje cells by 6 weeks of age.|T|G|51|35.0|Non-synonymous|Unprocessed|APF-G1
1784348|IGL00826|19|39739505|Y->H||0.83|Possibly damaging|0.32|tolerated|MGI:3612287|Cyp2c68|cytochrome P450, family 2, subfamily c, polypeptide 68 [Source:MGI Symbol;Acc:MGI:3612287]|Heterozygous||A|G|47|39.0|Non-synonymous|Unprocessed|APF-G1
1784349|IGL00826|8|19141407|V->G|||Benign|0.27|tolerated|MGI:3647173|Spag11b|sperm associated antigen 11B [Source:MGI Symbol;Acc:MGI:3647173]|Heterozygous||T|G|42|39.0|Non-synonymous|Unprocessed|APF-G1
1784350|IGL00826|18|20035315|A->T||1.0|Probably damaging||deleterious|MGI:103221|Dsc2|desmocollin 2 [Source:MGI Symbol;Acc:MGI:103221]|Heterozygous||C|T|37|37.0|Non-synonymous|Unprocessed|APF-G1
1784351|IGL00826|11|65989942|V->M||0.2|Benign|0.05|deleterious|MGI:1289279|Dnahc9|dynein, axonemal, heavy chain 9 [Source:MGI Symbol;Acc:MGI:1289279]|Heterozygous||C|T|30|39.5|Non-synonymous|Unprocessed|APF-G1
1784352|IGL00826|16|36800676|M->K||0.01|Benign|0.14|tolerated|MGI:2146616|Eaf2|ELL associated factor 2 [Source:MGI Symbol;Acc:MGI:2146616]|Heterozygous|Mice homozygous for a null allele exhibit premature death, enlarged heart and prostate associate with hypertrophy, and increased incidence of tumors.|A|T|30|39.0|Non-synonymous|Unprocessed|APF-G1
1784353|IGL00826|4|86156804|P->L||1.0|Probably damaging||deleterious|MGI:1924989|Adamtsl1|ADAMTS-like 1 [Source:MGI Symbol;Acc:MGI:1924989]|Heterozygous||C|T|30|38.0|Non-synonymous|Unprocessed|APF-G1
1784354|IGL00826|10|81118218|V->I||0.13|Benign|1.0|tolerated|MGI:1346867|Map2k2|mitogen-activated protein kinase kinase 2 [Source:MGI Symbol;Acc:MGI:1346867]|Heterozygous|Homozygotes for a targeted null mutation are viable, fertile, and apparently normal.|G|A|29|40.0|Non-synonymous|Unprocessed|APF-G1
1784355|IGL00826|7|104260933|I->T|||Benign|0.11|tolerated|MGI:2137359|Trim34a|tripartite motif-containing 34A [Source:MGI Symbol;Acc:MGI:2137359]|Heterozygous||T|C|29|37.0|Non-synonymous|Unprocessed|APF-G1
1784356|IGL00826|10|25441722|S->P||||0.34|tolerated|MGI:103009|Epb4.1l2|erythrocyte protein band 4.1-like 2 [Source:MGI Symbol;Acc:MGI:103009]|Heterozygous|Mice homozygous for a knock-out allele exhibit normal glutamatergic synapse formation, AMPAR responses and long-term potentiation. Male mice homozygous for a knock-out allele exhibit normal fertility. Male mice homozygous for a gene trap allele on a mixed background are infertile.|T|C|22|38.0|Non-synonymous|Unprocessed|APF-G1
1784357|IGL00826|8|57540071|Y->Stop|||N/A|||MGI:1349449|Galnt7|UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 7 [Source:MGI Symbol;Acc:MGI:1349449]|Heterozygous||A|T|22|37.5|Non-synonymous|Unprocessed|APF-G1
1784358|IGL00826|11|78015506|R->L||1.0|Probably damaging||deleterious|MGI:1924057|Phf12|PHD finger protein 12 [Source:MGI Symbol;Acc:MGI:1924057]|Heterozygous||G|T|20|35.5|Non-synonymous|Unprocessed|APF-G1
1784359|IGL00826|5|123512688|I->M|||Benign|0.06|tolerated|MGI:1913843|Diablo|diablo homolog (Drosophila) [Source:MGI Symbol;Acc:MGI:1913843]|Heterozygous|Homozygotes are viable and fertile with no gross morphological or histological abnormalities. Normal induction of apoptosis in UV-irradiated or Fas-antibody treated cells was noted, and these mice also exhibit normal T and B cell proliferative responses.|T|C|20|39.0|Non-synonymous|Unprocessed|APF-G1
1784360|IGL00826|2|121302276|Q->R||0.46|Possibly damaging|0.12|tolerated|MGI:1306776|Mtap1a|microtubule-associated protein 1 A [Source:MGI Symbol;Acc:MGI:1306776]|Heterozygous||A|G|17|37.0|Non-synonymous|Unprocessed|APF-G1
1784361|IGL00826|4|34721562|S->N||1.0|Probably damaging|0.01|deleterious|MGI:1916579|1700003m02rik|RIKEN cDNA 1700003M02 gene [Source:MGI Symbol;Acc:MGI:1916579]|Heterozygous||C|T|17|39.0|Non-synonymous|Unprocessed|APF-G1
1784362|IGL00826|4|86664446|N->D||0.96|Probably damaging|0.11|tolerated|MGI:87920|Plin2|perilipin 2 [Source:MGI Symbol;Acc:MGI:87920]|Heterozygous|Male mice homozygous for one disruption in this gene are infertile while no comment is made regarding fertility for another such allele.|T|C|17|36.0|Non-synonymous|Unprocessed|APF-G1
1784363|IGL00826|13|27640795|V->A||0.79|Possibly damaging|0.35|tolerated|MGI:1206572|Prl7a1|prolactin family 7, subfamily a, member 1 [Source:MGI Symbol;Acc:MGI:1206572]|Heterozygous||A|G|14|38.0|Non-synonymous|Unprocessed|APF-G1
1784364|IGL00826|14|55584920|L->I||0.89|Possibly damaging|0.02|deleterious|MGI:1934682|Fam158a|family with sequence similarity 158, member A [Source:MGI Symbol;Acc:MGI:1934682]|Heterozygous||G|T|13|35.0|Non-synonymous|Unprocessed|APF-G1
1784365|IGL00826|6|42269285|Y->Stop|||N/A|||MGI:97295|Casp2|caspase 2 [Source:MGI Symbol;Acc:MGI:97295]|Heterozygous|Homozygous mutation of this gene results in abnormal apoptosis. Apoptosis is reduced in the female germline, but is increased in sympathetic neurons during development.|T|A|12|39.5|Non-synonymous|Unprocessed|APF-G1
1784366|IGL00826|9|110626903|V->A|||Benign|0.09|tolerated|MGI:2448554|Nbeal2|neurobeachin-like 2 [Source:MGI Symbol;Acc:MGI:2448554]|Heterozygous||A|G|12|36.5|Non-synonymous|Unprocessed|APF-G1
1784367|IGL00826|7|75677447|N->K||0.99|Probably damaging||deleterious|MGI:2676556|Akap13|A kinase (PRKA) anchor protein 13 [Source:MGI Symbol;Acc:MGI:2676556]|Heterozygous||C|A|11|38.0|Non-synonymous|Unprocessed|APF-G1
1784368|IGL00826|13|104144508|S->T|||Benign|0.28|tolerated|MGI:1914225|2410002o22rik|RIKEN cDNA 2410002O22 gene [Source:MGI Symbol;Acc:MGI:1914225]|Heterozygous||A|T|10|36.0|Non-synonymous|Unprocessed|APF-G1
1784372|IGL00826|2|92344536|Disrupted splicing||||||MGI:2384756|Phf21a|PHD finger protein 21A [Source:MGI Symbol;Acc:MGI:2384756]|Heterozygous|Mice homozygous for a knock-out allele exhibit neonatal lethality and insufficient milk-sucking behavior.|T|G|94|38.0|Splice|Unprocessed|APF-G1
1784373|IGL00826|14|31012796|Disrupted splicing||||||MGI:1353651|Gnl3|guanine nucleotide binding protein-like 3 (nucleolar) [Source:MGI Symbol;Acc:MGI:1353651]|Heterozygous|Homozygous disruption of this gene leads to early embryonic loss as blastocysts fail to enter the S phase. MEFs heterozygous for a gene trap allele have reduced proliferative capacity while MEFs heterozygous for a null allele show reduced doubling rates, increased apoptosis and premature senescence.|A|G|22|37.5|Splice|Unprocessed|APF-G1
1784374|IGL00826|10|111272320|Disrupted splicing||||||MGI:2443807|Osbpl8|oxysterol binding protein-like 8 [Source:MGI Symbol;Acc:MGI:2443807]|Heterozygous||A|T|12|36.5|Splice|Unprocessed|APF-G1
1784375|IGL00826|11|97236058|Disrupted splicing||||||MGI:1101358|Npepps|aminopeptidase puromycin sensitive [Source:MGI Symbol;Acc:MGI:1101358]|Heterozygous|Homozygotes for a gene-trapped mutation exhibit dwarfism, increased anxiety, decreased pain sensitivity, and infertility in both sexes. Females fail to produce the corpus luteum of pregnancy, while males fail to copulate and have impaired spermatogenesis.|T|C|12|34.0|Splice|Unprocessed|APF-G1
1784846|IGL00827|15|39472359|G->D||0.83|Possibly damaging||deleterious|MGI:2152972|Rims2|regulating synaptic membrane exocytosis 2 [Source:MGI Symbol;Acc:MGI:2152972]|Heterozygous|Mice homozygous for a knock-out allele show reduced body size, aberrant insulin granule exocytosis, and impaired secretion of hormones associated with glucose homeostasis. Mice homozygous for another knock-out allele show a slightly reduced body size, abnormal maternal behavior and premature death.|G|A|144|38.0|Non-synonymous|Unprocessed|APF-G1
1784847|IGL00827|5|7976712|Y->C||1.0|Probably damaging|0.01|deleterious|MGI:1923560|Steap4|STEAP family member 4 [Source:MGI Symbol;Acc:MGI:1923560]|Heterozygous||A|G|138|31.0|Non-synonymous|Unprocessed|APF-G1
1784848|IGL00827|10|78053996|L->P||1.0|Probably damaging||deleterious|MGI:1859287|Dnmt3l|DNA (cytosine-5-)-methyltransferase 3-like [Source:MGI Symbol;Acc:MGI:1859287]|Heterozygous|Mutants in this imprinted gene lack appropriate methylation of the maternal allele and this, in turn, causes azoospermia in homozygous males; and heterozygous progeny of homozygous females die by midgestation.|T|C|112|39.0|Non-synonymous|Unprocessed|APF-G1
1784849|IGL00827|12|103579076|T->A|||Benign|1.0|tolerated|MGI:1921771|Ppp4r4|protein phosphatase 4, regulatory subunit 4 [Source:MGI Symbol;Acc:MGI:1921771]|Heterozygous||A|G|85|37.0|Non-synonymous|Unprocessed|APF-G1
1784850|IGL00827|3|98630098|A->V|||Benign|0.86|tolerated|MGI:104645|Hsd3b5|hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5 [Source:MGI Symbol;Acc:MGI:104645]|Heterozygous||G|A|69|37.0|Non-synonymous|Unprocessed|APF-G1
1784851|IGL00827|13|59689476|V->A||0.01|Benign|0.05|tolerated|MGI:1918150|4921517d22rik|RIKEN cDNA 4921517D22 gene [Source:MGI Symbol;Acc:MGI:1918150]|Heterozygous||A|G|39|39.0|Non-synonymous|Unprocessed|APF-G1
1784852|IGL00827|5|89179686|S->A|||Benign|0.04|deleterious|MGI:1927555|Slc4a4|solute carrier family 4 (anion exchanger), member 4 [Source:MGI Symbol;Acc:MGI:1927555]|Heterozygous|Mice homozygous for a null allele exhibit smaller birth size, growth retardation, postnatal lethality, bowel obstructions, altered blood chemistry, acidosis, spleen defects and defects in ion homeostasis.  Heterozygotes have decreased levels of circulating bicarbonate.|T|G|38|38.0|Non-synonymous|Unprocessed|APF-G1
1784853|IGL00827|11|69448457|K->E||0.21|Benign|0.03|deleterious|MGI:107731|Dnahc2|dynein, axonemal, heavy chain 2 [Source:MGI Symbol;Acc:MGI:107731]|Heterozygous||T|C|30|38.0|Non-synonymous|Unprocessed|APF-G1
1784855|IGL00827|10|80713559|D->E||0.56|Possibly damaging|0.18|tolerated|MGI:107734|Ap3d1|adaptor-related protein complex 3, delta 1 subunit [Source:MGI Symbol;Acc:MGI:107734]|Heterozygous|Mutations show coat and eye color dilution, platelet defects, lysosomal abnormalities, inner ear degeneration and neurological defects.  They model Hermansky-Pudlak storage pool deficiency syndrome.|A|T|25|35.0|Non-synonymous|Unprocessed|APF-G1
1784856|IGL00827|5|123864502|K->E||0.31|Benign|0.03|deleterious|MGI:1933383|Niacr1|niacin receptor 1 [Source:MGI Symbol;Acc:MGI:1933383]|Heterozygous|Mice homozygous for targeted mutations that inactivate the gene showed impaired reductions of free fatty acid (FFA) and triglyceride plasma levels in response to nicotinic acid.|T|C|23|37.0|Non-synonymous|Unprocessed|APF-G1
1784857|IGL00827|10|36997114|C->S|||Benign|0.69|tolerated|MGI:1097691|Hdac2|histone deacetylase 2 [Source:MGI Symbol;Acc:MGI:1097691]|Heterozygous|Mice homozygous for a null allele exhibit embryonic and postnatal lethality accompanied with a transient decrease in body size and increase in heart size and cardiomyocyte proliferation that is overcome by 2 months of age in surviving mice.|T|A|22|39.5|Non-synonymous|Unprocessed|APF-G1
1784858|IGL00827|15|91755790|I->F||0.89|Possibly damaging||deleterious|MGI:1913975|Lrrk2|leucine-rich repeat kinase 2 [Source:MGI Symbol;Acc:MGI:1913975]|Heterozygous|Mice homozygous for a knock-in allele exhibit impaired response to dopamine, amphetamine, and quinpirole.  Mice homozygous for one knock-out allele exhibit increased neurite growth. Mice homozygous for different knock-out alleles exhibit alopecia due to excessive grooming or kdiney atrophy.|A|T|16|36.5|Non-synonymous|Unprocessed|APF-G1
1784859|IGL00827|13|19594509|I->T||1.0|Probably damaging||deleterious|MGI:2145369|Epdr1|ependymin related protein 1 (zebrafish) [Source:MGI Symbol;Acc:MGI:2145369]|Heterozygous||A|G|15|38.0|Non-synonymous|Unprocessed|APF-G1
1784860|IGL00827|9|106474406|M->L||0.95|Possibly damaging|0.26|tolerated|MGI:1891258|Parp3|poly (ADP-ribose) polymerase family, member 3 [Source:MGI Symbol;Acc:MGI:1891258]|Heterozygous|Mice homozygous for a knock-out allele exhibit normal survival.|T|A|14|39.5|Non-synonymous|Unprocessed|APF-G1
1784861|IGL00827|19|41039823|G->D|||Benign|0.09|tolerated|MGI:98659|Dntt|deoxynucleotidyltransferase, terminal [Source:MGI Symbol;Acc:MGI:98659]|Heterozygous||G|A|12|38.5|Non-synonymous|Unprocessed|APF-G1
1784864|IGL00827|2|5311073|Disrupted splicing||||||MGI:2442190|Camk1d|calcium/calmodulin-dependent protein kinase ID [Source:MGI Symbol;Acc:MGI:2442190]|Heterozygous||G|A|26|38.0|Splice|Unprocessed|APF-G1
1784865|IGL00827|11|109677762|Disrupted splicing||||||MGI:2388266|Fam20a|family with sequence similarity 20, member A [Source:MGI Symbol;Acc:MGI:2388266]|Heterozygous||A|T|16|36.5|Splice|Unprocessed|APF-G1
1785314|IGL00828|9|44820776|N->S|||Unknown|0.32|tolerated|MGI:96995|Mll1|myeloid/lymphoid or mixed-lineage leukemia 1 [Source:MGI Symbol;Acc:MGI:96995]|Heterozygous|Homozygotes for targeted null mutations die at embryonic day 11.5-14.5 with edematous bodies, petechiae, and hematopoietic insufficiency. Heterozygotes show reduced growth, hematopoietic abnormalities, and homeotic transformations of the axial skeleton.|T|C|48|39.0|Non-synonymous|Unprocessed|APF-G1
1785315|IGL00828|9|78578551|A->V||0.12|Benign|0.27|tolerated|MGI:1924105|Slc17a5|solute carrier family 17 (anion/sugar transporter), member 5 [Source:MGI Symbol;Acc:MGI:1924105]|Heterozygous|Homozygous mutant mice exhibit numerous neurological abnormalities, including impaired exploratory and locomotor activity, hearing deficits, and an increased depressive-like response.|G|A|39|37.0|Non-synonymous|Unprocessed|APF-G1
1785316|IGL00828|7|104230743|T->A|||Benign|0.11|tolerated|MGI:2137352|Trim6|tripartite motif-containing 6 [Source:MGI Symbol;Acc:MGI:2137352]|Heterozygous||A|G|37|36.0|Non-synonymous|Unprocessed|APF-G1
1785317|IGL00828|1|105554120|Y->N||0.86|Possibly damaging|0.01|deleterious|MGI:1351629|Pign|phosphatidylinositol glycan anchor biosynthesis, class N [Source:MGI Symbol;Acc:MGI:1351629]|Heterozygous||A|T|28|38.0|Non-synonymous|Unprocessed|APF-G1
1785318|IGL00828|4|121074520|R->C||0.87|Possibly damaging|0.05|tolerated|MGI:1890508|Zmpste24|zinc metallopeptidase, STE24 homolog (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1890508]|Heterozygous|Mutants are deficient in proteolytic processing of prelamin A and display many abnormalities including retarded growth, bone fragility, hair loss, cardiomyopathy, muscular dystrophy and lipodystrophy. Most die prematurely, but some survive and reproduce.|G|A|26|39.0|Non-synonymous|Unprocessed|APF-G1
1785319|IGL00828|2|24971643|Q->L|||Benign|0.32|tolerated|MGI:1914478|Wdr85|WD repeat domain 85 [Source:MGI Symbol;Acc:MGI:1914478]|Heterozygous||A|T|17|40.0|Non-synonymous|Unprocessed|APF-G1
1785320|IGL00828|4|145701991|H->L|||Benign|0.59|tolerated|MGI:3712454|Gm13242|predicted gene 13242 [Source:MGI Symbol;Acc:MGI:3712454]|Heterozygous||A|T|17|39.0|Non-synonymous|Unprocessed|APF-G1
1785321|IGL00828|1|25488119|I->F||0.52|Possibly damaging|0.05|deleterious|MGI:2441837|Bai3|brain-specific angiogenesis inhibitor 3 [Source:MGI Symbol;Acc:MGI:2441837]|Heterozygous||T|A|15|38.0|Non-synonymous|Unprocessed|APF-G1
1785324|IGL00828|1|87978306|Disrupted splicing||||||MGI:2443184|Usp40|ubiquitin specific peptidase 40 [Source:MGI Symbol;Acc:MGI:2443184]|Heterozygous||G|A|48|39.0|Splice|Unprocessed|APF-G1
1785325|IGL00828|1|165338347|Disrupted splicing||||||MGI:1921356|Dcaf6|DDB1 and CUL4 associated factor 6 [Source:MGI Symbol;Acc:MGI:1921356]|Heterozygous||G|A|30|38.0|Splice|Unprocessed|APF-G1
1785326|IGL00828|2|31177783|Disrupted splicing||||||MGI:2139054|Gpr107|G protein-coupled receptor 107 [Source:MGI Symbol;Acc:MGI:2139054]|Heterozygous||A|T|15|38.0|Splice|Unprocessed|APF-G1
1785767|IGL00832|7|4341288|T->N||0.43|Benign|0.12|tolerated|MGI:1336212|Ncr1|natural cytotoxicity triggering receptor 1 [Source:MGI Symbol;Acc:MGI:1336212]|Heterozygous||C|A|75|40.0|Non-synonymous|Unprocessed|APF-G1
1785768|IGL00832|16|5088975|L->H||1.0|Probably damaging||deleterious|MGI:1194898|Ppl|periplakin [Source:MGI Symbol;Acc:MGI:1194898]|Heterozygous|Homozygous null mice are fertile and grossly normal with no apparent skin abnormalities.|A|T|72|38.0|Non-synonymous|Unprocessed|APF-G1
1785769|IGL00832|9|7387023|Q->L||0.89|Possibly damaging||deleterious|MGI:1933847|Mmp1b|matrix metallopeptidase 1b (interstitial collagenase) [Source:MGI Symbol;Acc:MGI:1933847]|Heterozygous||T|A|63|39.0|Non-synonymous|Unprocessed|APF-G1
1785770|IGL00832|16|92077631|M->T||1.0|Probably damaging||deleterious|MGI:1858226, MGI:2153111|Slc5a3,mrps6|mitochondrial ribosomal protein S6 [Source:MGI Symbol;Acc:MGI:2153111],solute carrier family 5 (inositol transporters), member 3 [Source:MGI Symbol;Acc:MGI:1858226]|Heterozygous|NO_PHENOTYPE,Homozygous mutation of this gene results in lethality shortly after birth due to respiratory failure and abnormal development of peripheral nerves.|T|C|60|39.0|Non-synonymous|Unprocessed|APF-G1
1785771|IGL00832|5|150066428|M->L|||Benign|0.18|tolerated|MGI:2153463|Rxfp2|relaxin/insulin-like family peptide receptor 2 [Source:MGI Symbol;Acc:MGI:2153463]|Heterozygous|Male homozygotes for a targeted null mutation exhibit bilateral intraabdominal cryptorchidism and sterility associated with a failure in the differentiation of the gubernaculae, ligaments that control testicular movement during development.|A|T|60|40.0|Non-synonymous|Unprocessed|APF-G1
1785772|IGL00832|2|132546850|T->M||0.97|Probably damaging|0.04|deleterious|MGI:104898|Gpcpd1|glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:104898]|Heterozygous||G|A|55|40.0|Non-synonymous|Unprocessed|APF-G1
1785773|IGL00832|2|172249028|I->F||0.15|Benign|0.05|deleterious|MGI:96929|Mc3r|melanocortin 3 receptor [Source:MGI Symbol;Acc:MGI:96929]|Heterozygous||A|T|50|39.5|Non-synonymous|Unprocessed|APF-G1
1785774|IGL00832|9|78434317|C->S||1.0|Probably damaging|0.09|tolerated|MGI:2442261|E330016a19rik|RIKEN cDNA E330016A19 gene [Source:MGI Symbol;Acc:MGI:2442261]|Heterozygous||A|T|47|39.0|Non-synonymous|Unprocessed|APF-G1
1785775|IGL00832|4|48468864|T->A|||Benign|1.0|tolerated|MGI:1344413|Tex10|testis expressed gene 10 [Source:MGI Symbol;Acc:MGI:1344413]|Heterozygous||T|C|45|40.0|Non-synonymous|Unprocessed|APF-G1
1785776|IGL00832|5|31173005|P->L|||Unknown|0.08|tolerated|MGI:1919002|Gtf3c2|general transcription factor IIIC, polypeptide 2, beta [Source:MGI Symbol;Acc:MGI:1919002]|Heterozygous||G|A|42|39.5|Non-synonymous|Unprocessed|APF-G1
1785777|IGL00832|8|24584559|T->I||0.6|Possibly damaging||deleterious|MGI:96416|Ido1|indoleamine 2,3-dioxygenase 1 [Source:MGI Symbol;Acc:MGI:96416]|Heterozygous||G|A|38|40.0|Non-synonymous|Unprocessed|APF-G1
1785778|IGL00832|9|35478116|I->N||1.0|Probably damaging||deleterious|MGI:1926387|Cdon|cell adhesion molecule-related/down-regulated by oncogenes [Source:MGI Symbol;Acc:MGI:1926387]|Heterozygous|Homozygous null mice display facial defects characteristic of microform holoprosencephaly, are runted, and are prone to death prior to weaning.|T|A|34|38.0|Non-synonymous|Unprocessed|APF-G1
1785779|IGL00832|8|72455349|Y->C||1.0|Probably damaging||deleterious|MGI:1919504|1700030k09rik|RIKEN cDNA 1700030K09 gene [Source:MGI Symbol;Acc:MGI:1919504]|Heterozygous||A|G|33|39.0|Non-synonymous|Unprocessed|APF-G1
1785780|IGL00832|5|88385049|H->Q||0.01|Benign|0.38|tolerated|MGI:1918671|Amtn|amelotin [Source:MGI Symbol;Acc:MGI:1918671]|Heterozygous||T|G|31|39.0|Non-synonymous|Unprocessed|APF-G1
1785781|IGL00832|11|94303942|D->G||0.83|Possibly damaging|0.04|deleterious|MGI:1914934|Luc7l3|LUC7-like 3 (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1914934]|Heterozygous||T|C|28|39.0|Non-synonymous|Unprocessed|APF-G1
1785782|IGL00832|8|91085445|D->G||1.0|Probably damaging|0.13|tolerated|MGI:105085|Rbl2|retinoblastoma-like 2 [Source:MGI Symbol;Acc:MGI:105085]|Heterozygous|Homozygotes for targeted null mutations exhibit arrested embryonic growth and varying disorganization in neural and dermamyotome structures, with death by embryonic day 11-13. On a different background mutants were viable and fertile.|A|G|25|38.0|Non-synonymous|Unprocessed|APF-G1
1785783|IGL00832|11|4791123|K->E|||Benign|0.38|tolerated|MGI:97307|Nf2|neurofibromatosis 2 [Source:MGI Symbol;Acc:MGI:97307]|Heterozygous|Homozygous targeted null mutants lack extraembryonic ectoderm, do not initiate gastrulation and die by embryonic day 7. Heterozygotes develop malignant tumors, especially osteosarcomas. Conditional Schwann cell knockouts resemble neurofibromatosis type 2.|T|C|24|38.5|Non-synonymous|Unprocessed|APF-G1
1785784|IGL00832|8|46581597|V->A||0.95|Possibly damaging|0.3|tolerated|MGI:3603756|Ccdc111|coiled-coil domain containing 111 [Source:MGI Symbol;Acc:MGI:3603756]|Heterozygous||A|G|24|37.5|Non-synonymous|Unprocessed|APF-G1
1785785|IGL00832|9|87705661|S->C||1.0|Probably damaging|0.08|tolerated|MGI:1923615|Tbx18|T-box18 [Source:MGI Symbol;Acc:MGI:1923615]|Heterozygous|Homozygous null mice fail to maintain anterior-posterior polarity of the lateral sclerotome and display neonatal lethality and abnormal vertebral, rib, and spinal nerve morphology.|T|A|23|38.0|Non-synonymous|Unprocessed|APF-G1
1785786|IGL00832|3|3641276|C->Y||1.0|Probably damaging||deleterious|MGI:1353604|Hnf4g|hepatocyte nuclear factor 4, gamma [Source:MGI Symbol;Acc:MGI:1353604]|Heterozygous|Mice homozygous for a knock-out allele are less inclined to build nests, spend more time in a passive state during the forced swim test, and display a reduction in energy expenditure and night time activity that results in increased body weight despite a decreased intake of food and water.|G|A|21|40.0|Non-synonymous|Unprocessed|APF-G1
1785787|IGL00832|16|93763401|V->A||0.01|Benign|0.5|tolerated|MGI:1917278|Dopey2|dopey family member 2 [Source:MGI Symbol;Acc:MGI:1917278]|Heterozygous||T|C|18|37.5|Non-synonymous|Unprocessed|APF-G1
1785788|IGL00832|7|48868203|G->D||0.98|Probably damaging|0.08|tolerated|MGI:1922038|E2f8|E2F transcription factor 8 [Source:MGI Symbol;Acc:MGI:1922038]|Heterozygous|Mice homozygous for a knock-out allele develop normally through puberty and live to old age.|C|T|16|36.5|Non-synonymous|Unprocessed|APF-G1
1785789|IGL00832|3|80707251|D->G||0.99|Probably damaging|0.01|deleterious|MGI:95809|Gria2|glutamate receptor, ionotropic, AMPA2 (alpha 2) [Source:MGI Symbol;Acc:MGI:95809]|Heterozygous|Homozygotes for targeted null mutations exhibit epilepsy, deficient dendritic architecture, altered exploratory behavior, impaired motor and learning performance, and increased mortality.|T|C|15|40.0|Non-synonymous|Unprocessed|APF-G1
1785790|IGL00832|4|43258921|V->G||1.0|Probably damaging||deleterious|MGI:1342278|Unc13b|unc-13 homolog B (C. elegans) [Source:MGI Symbol;Acc:MGI:1342278]|Heterozygous|Homozygous mutant mice are grossly phenotypically normal. Mice older than 12 months will exhibit sporadic seizures.|T|G|13|36.0|Non-synonymous|Unprocessed|APF-G1
1785791|IGL00832|13|22088181|T->A||0.91|Possibly damaging|0.05|tolerated|MGI:2182259|Vmn1r188|vomeronasal 1 receptor 188 [Source:MGI Symbol;Acc:MGI:2182259]|Heterozygous||A|G|12|37.0|Non-synonymous|Unprocessed|APF-G1
1785792|IGL00832|14|31528346|C->Stop|||N/A|||MGI:1338761|Colq|collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase [Source:MGI Symbol;Acc:MGI:1338761]|Heterozygous|Homozygotes for targeted null mutations exhibit tremors, reduced body weight, lack of asymmetric forms of acetylcholinesterase and butyrylcholinesterase, and lethality prior to maturation.|G|T|11|37.0|Non-synonymous|Unprocessed|APF-G1
1785797|IGL00832|7|125654460|Disrupted splicing||||||MGI:107887|Gtf3c1|general transcription factor III C 1 [Source:MGI Symbol;Acc:MGI:107887]|Heterozygous||T|C|69|37.0|Splice|Unprocessed|APF-G1
1785798|IGL00832|2|62645470|Disrupted splicing||||||MGI:1918836|Ifih1|interferon induced with helicase C domain 1 [Source:MGI Symbol;Acc:MGI:1918836]|Heterozygous|Mice homozygous for a null allele have increased virus-associated morbidity and mortality, and decreased cytokine response to  several viral infection.|A|G|37|37.0|Splice|Unprocessed|APF-G1
1785799|IGL00832|5|114368936|Disrupted splicing||||||MGI:2141207|Kctd10|potassium channel tetramerisation domain containing 10 [Source:MGI Symbol;Acc:MGI:2141207]|Heterozygous||C|A|32|36.5|Splice|Unprocessed|APF-G1
1785800|IGL00832|2|71838262|Disrupted splicing||||||MGI:96605|Itga6|integrin alpha 6 [Source:MGI Symbol;Acc:MGI:96605]|Heterozygous|Homozygotes for a targeted null mutation exhibit severe blistering of the skin and other epithelia, absence of hemidesmosomes, altered laminin deposition in brain, and ectopic neuroblastic outgrowths on the brain and in the eye. Mutants die at birth.|A|G|30|39.0|Splice|Unprocessed|APF-G1
1785801|IGL00832|8|104967839|Disrupted splicing||||||MGI:1919611|Ces2g|carboxylesterase 2G [Source:MGI Symbol;Acc:MGI:1919611]|Heterozygous||A|G|29|39.0|Splice|Unprocessed|APF-G1
1785802|IGL00832|2|119755605|Disrupted splicing||||||MGI:96840|Ltk|leukocyte tyrosine kinase [Source:MGI Symbol;Acc:MGI:96840]|Heterozygous||A|T|20|37.0|Splice|Unprocessed|APF-G1
1786258|IGL00833|2|150472729|E->G||1.0|Probably damaging|0.01|deleterious|MGI:3652219|Zfp345|zinc finger protein 345 [Source:MGI Symbol;Acc:MGI:3652219]|Heterozygous||T|C|77|41.0|Non-synonymous|Unprocessed|APF-G1
1786259|IGL00833|1|138078492|K->R||0.32|Benign|0.18|tolerated|MGI:97810|Ptprc|protein tyrosine phosphatase, receptor type, C [Source:MGI Symbol;Acc:MGI:97810]|Heterozygous|Homozygous null mutants have defective T cell, B cell, and NK cell morphology and physiology. Mice carrying an engineered point mutation exhibit lymphoproliferation and autoimmunity that leads to premature death.|T|C|55|41.0|Non-synonymous|Unprocessed|APF-G1
1786260|IGL00833|3|96578560|D->A||0.99|Probably damaging|0.01|deleterious|MGI:1917120|Polr3gl|polymerase (RNA) III (DNA directed) polypeptide G like [Source:MGI Symbol;Acc:MGI:1917120]|Heterozygous||T|G|46|40.0|Non-synonymous|Unprocessed|APF-G1
1786261|IGL00833|11|106231178|V->D||0.01|Benign|0.63|tolerated|MGI:1919297|Ddx42|DEAD (Asp-Glu-Ala-Asp) box polypeptide 42 [Source:MGI Symbol;Acc:MGI:1919297]|Heterozygous||T|A|41|37.0|Non-synonymous|Unprocessed|APF-G1
1786262|IGL00833|4|116602736|V->A||0.99|Probably damaging|0.01|deleterious|MGI:1355328|Nasp|nuclear autoantigenic sperm protein (histone-binding) [Source:MGI Symbol;Acc:MGI:1355328]|Heterozygous|Mice homozygous for a null mutation display embryonic lethality before implantation.|A|G|40|40.0|Non-synonymous|Unprocessed|APF-G1
1786263|IGL00833|9|70338778|I->T||0.07|Benign|0.01|deleterious|MGI:106621|Myo1e|myosin IE [Source:MGI Symbol;Acc:MGI:106621]|Heterozygous|Mice homozygous for a gene trapped allele exhibit embryonic lethality, embryonic hemorrhaging and hematopoietic defects.|T|C|36|39.0|Non-synonymous|Unprocessed|APF-G1
1786264|IGL00833|1|126027152|K->N||1.0|Probably damaging||deleterious|MGI:2686394|Nckap5|NCK-associated protein 5 [Source:MGI Symbol;Acc:MGI:2686394]|Heterozygous||C|A|32|39.5|Non-synonymous|Unprocessed|APF-G1
1786265|IGL00833|2|154528875|Y->N||1.0|Probably damaging|0.01|deleterious|MGI:1333833|Cbfa2t2|core-binding factor, runt domain, alpha subunit 2, translocated to, 2 (human) [Source:MGI Symbol;Acc:MGI:1333833]|Heterozygous|Mice homozygous for a targeted null allele display reduced body size, decreased numbers of intestinal goblet, Paneth, and enteroendocrine cells, small intestinal inflammation, and strain background dependent partial postnatal lethality.|T|A|31|40.0|Non-synonymous|Unprocessed|APF-G1
1786266|IGL00833|12|118179580|F->L||1.0|Probably damaging|0.04|deleterious|MGI:1100864|Dnahc11|dynein, axonemal, heavy chain 11 [Source:MGI Symbol;Acc:MGI:1100864]|Heterozygous|Approximately half of live-born homozygous mutants show situs inversus indicating that this gene is no longer properly controlling left-right asymmetry.|A|G|30|39.0|Non-synonymous|Unprocessed|APF-G1
1786267|IGL00833|2|113296849|I->N||0.72|Possibly damaging||deleterious|MGI:1922525|Tmco5b|transmembrane and coiled-coil domains 5B [Source:MGI Symbol;Acc:MGI:1922525]|Heterozygous||T|A|30|39.0|Non-synonymous|Unprocessed|APF-G1
1786268|IGL00833|6|33971924|E->K||1.0|Probably damaging||deleterious|MGI:1096376|Exoc4|exocyst complex component 4 [Source:MGI Symbol;Acc:MGI:1096376]|Heterozygous|Mice homozygous for disruptions in this gene display embryonic abnormatlities.  Gastrulation is not completed and mesoderm formation is abnormal.  Death occurs before E10.5.|G|A|24|39.0|Non-synonymous|Unprocessed|APF-G1
1786269|IGL00833|4|15964320|I->V|||Benign|0.56|tolerated|MGI:1351625|Nbn|nibrin [Source:MGI Symbol;Acc:MGI:1351625]|Heterozygous|Homozygous targeted mutations exhibit phenotypes ranging from impaired extraembryonic tissue growth and early embryonic death to growth retardation, lymphoid defects, lymphoma susceptibility, and failure of oogenesis. Null heterozygotes are cancer prone.|A|G|22|38.5|Non-synonymous|Unprocessed|APF-G1
1786270|IGL00833|18|5767774|T->A|||Benign|0.79|tolerated|MGI:1344313|Zeb1|zinc finger E-box binding homeobox 1 [Source:MGI Symbol;Acc:MGI:1344313]|Heterozygous|Mutations at this locus affect thymus organization and homozygotes exhibit severe thymic T cell deficiency. Some mutations also exhibit extensive skeletal abnormalities. Homozygotes generally die at birth.|A|G|21|39.0|Non-synonymous|Unprocessed|APF-G1
1786271|IGL00833|16|30309466|D->G||0.51|Possibly damaging|0.18|tolerated|MGI:1096363|Gp5|glycoprotein 5 (platelet) [Source:MGI Symbol;Acc:MGI:1096363]|Heterozygous|Homozygotes for one null allele develop normally with no spontaneous bleeding while their platelets show normal thrombin responsiveness and lack a Bernard-Soulier phenotype. In contrast, homozygotes for a second null allele show a shorter bleeding time and platelet hyperresponsiveness to thrombin.|T|C|17|38.0|Non-synonymous|Unprocessed|APF-G1
1786272|IGL00833|2|154264275|Q->Stop|||N/A|||MGI:3582466, MGI:104739, MGI:3767993, MGI:3526919, MGI:2149372, MGI:3762229, MGI:3582467, MGI:3624657, MGI:3759761|4833413d08rik|RIKEN cDNA 4833413D08 gene [Source:MGI Symbol;Acc:MGI:3767993]|Heterozygous||C|T|17|41.0|Non-synonymous|Unprocessed|APF-G1
1786273|IGL00833|11|61217180|E->G||0.99|Probably damaging||deleterious|MGI:1353451|Aldh3a1|aldehyde dehydrogenase family 3, subfamily A1 [Source:MGI Symbol;Acc:MGI:1353451]|Heterozygous|Homozygous mutation of this gene does not result in a phenotype.|A|G|15|36.0|Non-synonymous|Unprocessed|APF-G1
1786274|IGL00833|17|36187041|S->R|||Benign|0.01|deleterious|MGI:95959|H2-t3|histocompatibility 2, T region locus 3 [Source:MGI Symbol;Acc:MGI:95959]|Heterozygous|This locus contains the sole gene encoding the thymic leukemia antigen or TL antigen in b haplotype mice such as C57BL/6.  Mice homozygous for a targeted knock-out are viable with normal reproduction.|T|G|15|40.0|Non-synonymous|Unprocessed|APF-G1
1786275|IGL00833|7|23340471|V->I|||Benign|0.1|tolerated|MGI:3056600|Nlrp4e|NLR family, pyrin domain containing 4E [Source:MGI Symbol;Acc:MGI:3056600]|Heterozygous||G|A|15|39.0|Non-synonymous|Unprocessed|APF-G1
1786276|IGL00833|8|3852800|M->R|||Benign|0.11|tolerated|MGI:2157948|Cd209e|CD209e antigen [Source:MGI Symbol;Acc:MGI:2157948]|Heterozygous||A|C|14|39.0|Non-synonymous|Unprocessed|APF-G1
1786277|IGL00833|12|8010101|V->A||0.02|Benign|1.0|tolerated|MGI:88052|Apob|apolipoprotein B [Source:MGI Symbol;Acc:MGI:88052]|Heterozygous|Homozygous null mutants usually die by midgestation and longer survivors exhibit exencephaly. Heterozygotes show reduced plasma cholesterol and apolipoprotein levels. Single isoform B100 and B48 null mutants are viable.|T|C|13|36.0|Non-synonymous|Unprocessed|APF-G1
1786278|IGL00833|15|66688801|T->I||0.72|Possibly damaging|0.14|tolerated|MGI:98733|Tg|thyroglobulin [Source:MGI Symbol;Acc:MGI:98733]|Heterozygous|Mice homozygous for a spontaneous mutation exhibit enlarged thyroid gland, hypothyroidism, abnormal thyroid gland morphology, and decreased body weight.|C|T|12|37.5|Non-synonymous|Unprocessed|APF-G1
1786281|IGL00833|3|102876301|Disrupted splicing||||||MGI:105931|Sycp1|synaptonemal complex protein 1 [Source:MGI Symbol;Acc:MGI:105931]|Heterozygous|Homozygous null mice display male and female infertility, azoospermia, small ovary, small testis and seminiferous tubules, absent ovarian follicles, and failure of synapse formation during meiosis.|A|G|74|40.0|Splice|Unprocessed|APF-G1
1786282|IGL00833|4|139393159|Disrupted splicing||||||MGI:1916366|Ubr4|ubiquitin protein ligase E3 component n-recognin 4 [Source:MGI Symbol;Acc:MGI:1916366]|Heterozygous||G|A|20|40.0|Splice|Unprocessed|APF-G1
1786732|IGL00834|10|58453323|T->K||0.6|Possibly damaging|0.6|tolerated|MGI:894323|Ranbp2|RAN binding protein 2 [Source:MGI Symbol;Acc:MGI:894323]|Heterozygous|Mice homozygous for a gene trap allele display embryonic lethality. Heterozygous mice on some backgrounds display reduced ATP levels in the CNS, decreased glucose clearance, decreased weight gain on a high fat diet, and reduced scotopic responses.|C|A|230|41.0|Non-synonymous|Unprocessed|APF-G1
1786733|IGL00834|9|20786389|Q->Stop|||N/A|||MGI:1858212|Col5a3|collagen, type V, alpha 3 [Source:MGI Symbol;Acc:MGI:1858212]|Heterozygous|Mice homozygous for a null mutation show decreased pancreatic beta cell mass, hyperglycemia, hypoinsulinemia, impaired glucose tolerance, insulin resistance and impaired glucose uptake. Homozygous females show decreased susceptibility to diet-induced obesity and a thin hypodermal fat layer.|G|A|110|38.0|Non-synonymous|Unprocessed|APF-G1
1786734|IGL00834|12|65043263|D->G||0.99|Probably damaging|0.02|deleterious|MGI:104602|Prpf39|PRP39 pre-mRNA processing factor 39 homolog (yeast) [Source:MGI Symbol;Acc:MGI:104602]|Heterozygous||A|G|93|40.0|Non-synonymous|Unprocessed|APF-G1
1786735|IGL00834|13|74736974|T->S||1.0|Probably damaging|0.09|tolerated|MGI:1098236|Cast|calpastatin [Source:MGI Symbol;Acc:MGI:1098236]|Heterozygous|Mice homozygous for a knockout allele exhibit augmented DNA fragmentation in CA1 pyramidal neurons following excitotoxic kainate treatment.|T|A|76|40.0|Non-synonymous|Unprocessed|APF-G1
1786736|IGL00834|11|36024258|I->F||1.0|Probably damaging||deleterious|MGI:1345184|Odz2|odd Oz/ten-m homolog 2 (Drosophila) [Source:MGI Symbol;Acc:MGI:1345184]|Heterozygous||T|A|72|38.0|Non-synonymous|Unprocessed|APF-G1
1786737|IGL00834|8|21861936|C->S||0.99|Probably damaging|||MGI:2179205|Defb10|defensin beta 10 [Source:MGI Symbol;Acc:MGI:2179205]|Heterozygous||T|A|65|38.0|Non-synonymous|Unprocessed|APF-G1
1786738|IGL00834|1|150630340|V->I|||Benign|1.0|tolerated|MGI:2685047|Hmcn1|hemicentin 1 [Source:MGI Symbol;Acc:MGI:2685047]|Heterozygous||C|T|63|41.0|Non-synonymous|Unprocessed|APF-G1
1786739|IGL00834|19|32698568|C->F||0.01|Benign|0.22|tolerated|MGI:1915229|Atad1|ATPase family, AAA domain containing 1 [Source:MGI Symbol;Acc:MGI:1915229]|Heterozygous|Mice homozygous for a knock-out allele exhibit decreased body size, seizure, absent LTD, enhanced LTP, enhanced AMPA-mediated currents, and premature death.|C|A|61|38.0|Non-synonymous|Unprocessed|APF-G1
1786740|IGL00834|11|106818217|I->F||0.7|Possibly damaging|0.03|deleterious|MGI:2443502|Ccdc45|coiled-coil domain containing 45 [Source:MGI Symbol;Acc:MGI:2443502]|Heterozygous||A|T|57|39.0|Non-synonymous|Unprocessed|APF-G1
1786741|IGL00834|11|107073928|V->A||0.12|Benign|||MGI:2444008|Bptf|bromodomain PHD finger transcription factor [Source:MGI Symbol;Acc:MGI:2444008]|Heterozygous|Mice homozygous for a null mutation display embryonic lethality during organogenesis with embryonic growth arrest around early gastrulation and a greatly reduced ectoplacental cone.|A|G|57|39.0|Non-synonymous|Unprocessed|APF-G1
1786742|IGL00834|5|75645959|N->T||1.0|Probably damaging||deleterious|MGI:96677|Kit|kit oncogene [Source:MGI Symbol;Acc:MGI:96677]|Heterozygous|Mutations at this locus affect migration of embryonic stem cell populations, resulting in mild to severe impairments in hemopoiesis, and pigmentation. Some alleles are homozygous lethal, sterile, or result in the formation of gastrointestinal tumors.|A|C|49|38.0|Non-synonymous|Unprocessed|APF-G1
1786743|IGL00834|2|130275995|H->Q||0.29|Benign|0.36|tolerated|MGI:1914384|Nop56|NOP56 ribonucleoprotein homolog (yeast) [Source:MGI Symbol;Acc:MGI:1914384]|Heterozygous||T|A|46|40.0|Non-synonymous|Unprocessed|APF-G1
1786744|IGL00834|11|91576380|I->N||1.0|Probably damaging||deleterious|MGI:1920720|Kif2b|kinesin family member 2B [Source:MGI Symbol;Acc:MGI:1920720]|Heterozygous||A|T|42|39.0|Non-synonymous|Unprocessed|APF-G1
1786745|IGL00834|7|3650855|A->V||1.0|Probably damaging||deleterious|MGI:2385261|Cnot3|CCR4-NOT transcription complex, subunit 3 [Source:MGI Symbol;Acc:MGI:2385261]|Heterozygous||C|T|41|37.0|Non-synonymous|Unprocessed|APF-G1
1786746|IGL00834|11|94949378|D->G|||Unknown|0.02|deleterious|MGI:88467|Col1a1|collagen, type I, alpha 1 [Source:MGI Symbol;Acc:MGI:88467]|Heterozygous|Mutations in this locus cause variable phenotype, from embryonic lethal to viable/fertile with altered fibrillogenesis. Homozygotes can show impaired bone formation and fragility, osteoporosis, dermal fibrosis, impaired uterine postpartum involution, and aortic dissection.|A|G|39|38.0|Non-synonymous|Unprocessed|APF-G1
1786747|IGL00834|16|84965711|F->I||0.95|Possibly damaging|0.46|tolerated|MGI:88059|App|amyloid beta (A4) precursor protein [Source:MGI Symbol;Acc:MGI:88059]|Heterozygous|Mice homozygous for disruptions in this gene exhibit reduced body weight, brain weight, size of forebrain commissures, locomotor activity, forelimb grip strength, and spatial learning scores. Many mice also exhibit agenesis of the corpus callosum, and extensive reactive gliosis.|A|T|39|40.0|Non-synonymous|Unprocessed|APF-G1
1786748|IGL00834|2|68118706|S->L||1.0|Probably damaging||deleterious|MGI:1349403|B3galt1|UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 [Source:MGI Symbol;Acc:MGI:1349403]|Heterozygous||C|T|35|40.0|Non-synonymous|Unprocessed|APF-G1
1786749|IGL00834|7|90382636|K->E|||||deleterious|MGI:1933366|Sytl2|synaptotagmin-like 2 [Source:MGI Symbol;Acc:MGI:1933366]|Heterozygous|Mice homozygous for a null allele display abnormal gastric surface mucus cell morphology and reduced basal mucin secretion from gastric cells|A|G|35|40.0|Non-synonymous|Unprocessed|APF-G1
1786750|IGL00834|17|12411493|L->Q||1.0|Probably damaging||deleterious|MGI:97620|Plg|plasminogen [Source:MGI Symbol;Acc:MGI:97620]|Heterozygous|Homozygous null mutants exhibit retarded growth, variable rectal prolapse, impaired fertility and lactation in females, early mortality, and widespread fibrin deposition and thrombotic lesions in liver, lung, stomach and other tissues.|T|A|34|39.0|Non-synonymous|Unprocessed|APF-G1
1786751|IGL00834|2|180689526|T->M||0.95|Possibly damaging|0.13|tolerated|MGI:1344352|Dido1|death inducer-obliterator 1 [Source:MGI Symbol;Acc:MGI:1344352]|Heterozygous|Mice homozygous for a knock-out allele exhibit severely reduced fertility; about one-half develop a transplantable disease characterized by anomalies in spleen, bone marrow, and peripheral blood and including anemia and various symptoms typical of myeloid dysplasia or myeloid proliferation.|G|A|34|37.0|Non-synonymous|Unprocessed|APF-G1
1786752|IGL00834|5|129716765|V->I||0.04|Benign|0.17|tolerated|MGI:1913508|Mrps17|mitochondrial ribosomal protein S17 [Source:MGI Symbol;Acc:MGI:1913508]|Heterozygous||G|A|32|37.0|Non-synonymous|Unprocessed|APF-G1
1786753|IGL00834|19|3649404|F->I|||Benign|0.45|tolerated|MGI:1278315|Lrp5|low density lipoprotein receptor-related protein 5 [Source:MGI Symbol;Acc:MGI:1278315]|Heterozygous|Homozygous mutants show variable bone loss, decreased osteoblast proliferation, impaired glucose tolerance, increased plasma cholesterol on high-fat diet and persistent embryonic eye vascularization, depending on allelic combination and strain background.|A|T|27|39.0|Non-synonymous|Unprocessed|APF-G1
1786754|IGL00834|11|72982787|I->L||0.46|Possibly damaging|0.03|deleterious|MGI:1194503|Atp2a3|ATPase, Ca++ transporting, ubiquitous [Source:MGI Symbol;Acc:MGI:1194503]|Heterozygous|Homozygous mutation of this gene results in reduced endothelial-dependent relaxation in the aorta.|A|C|25|39.0|Non-synonymous|Unprocessed|APF-G1
1786755|IGL00834|19|4194520|T->A||0.83|Possibly damaging|0.06|tolerated|MGI:103016|Ppp1ca|protein phosphatase 1, catalytic subunit, alpha isoform [Source:MGI Symbol;Acc:MGI:103016]|Heterozygous||A|G|24|38.0|Non-synonymous|Unprocessed|APF-G1
1786756|IGL00834|9|58199786|T->A||0.01|Benign|0.17|tolerated|MGI:2444277|Islr2|immunoglobulin superfamily containing leucine-rich repeat 2 [Source:MGI Symbol;Acc:MGI:2444277]|Heterozygous|Mice homozygous for a knock-out allele exhibit perinatal lethality, absent tail pinch response, and defective peroneal and tibial nerve morphology and branch extension.|T|C|24|36.5|Non-synonymous|Unprocessed|APF-G1
1786757|IGL00834|6|107568308|T->A|||Benign|0.12|tolerated|MGI:106038|Lrrn1|leucine rich repeat protein 1, neuronal [Source:MGI Symbol;Acc:MGI:106038]|Heterozygous||A|G|20|36.5|Non-synonymous|Unprocessed|APF-G1
1786758|IGL00834|2|13381927|G->D||1.0|Probably damaging|0.18|tolerated|MGI:1931256|Cubn|cubilin (intrinsic factor-cobalamin receptor) [Source:MGI Symbol;Acc:MGI:1931256]|Heterozygous|Mice homozygous for a null mutation display embryonic lethality during organogenesis, yolk sac and allantoic vasculature defects, embryonic and visceral endoderm defects, and lack somites.  Heterozygotes display incomplete penetrance of premature death.|C|T|15|39.0|Non-synonymous|Unprocessed|APF-G1
1786759|IGL00834|11|79027517|F->L||1.0|Probably damaging||deleterious|MGI:105051|Ksr1|kinase suppressor of ras 1 [Source:MGI Symbol;Acc:MGI:105051]|Heterozygous|Homozygous mutant mice exhibit disorganized hair follicles and a decreased susceptibility to papilloma formation.|A|G|13|34.0|Non-synonymous|Unprocessed|APF-G1
1786760|IGL00834|9|57415140|F->L|||Benign|1.0|tolerated|MGI:1914062|Ppcdc|phosphopantothenoylcysteine decarboxylase [Source:MGI Symbol;Acc:MGI:1914062]|Heterozygous||A|G|12|37.0|Non-synonymous|Unprocessed|APF-G1
1786763|IGL00834|7|129593093|Disrupted splicing||||||MGI:1932404|Wdr11|WD repeat domain 11 [Source:MGI Symbol;Acc:MGI:1920230]|Heterozygous||T|G|52|40.0|Splice|Unprocessed|APF-G1
1786764|IGL00834|3|90279686|Disrupted splicing||||||MGI:2446201|Dennd4b|DENN/MADD domain containing 4B [Source:MGI Symbol;Acc:MGI:2446201]|Heterozygous||T|C|44|37.0|Splice|Unprocessed|APF-G1
1786765|IGL00834|13|4512665|Disrupted splicing||||0.17|tolerated|MGI:2151104|Akr1c20|aldo-keto reductase family 1, member C20 [Source:MGI Symbol;Acc:MGI:2151104]|Heterozygous||A|G|42|40.0|Splice|Unprocessed|APF-G1
1786766|IGL00834|3|54744719|Disrupted splicing||||||MGI:1913498|Alg5|asparagine-linked glycosylation 5 homolog (yeast, dolichyl-phosphate beta-glucosyltransferase) [Source:MGI Symbol;Acc:MGI:1913498]|Heterozygous|Embryos homozygous for an ENU-induced mutation arrest unturned at E9.5 and display no left-right asymmetry.|T|C|37|40.0|Splice|Unprocessed|APF-G1
1787237|IGL00835|7|13909789|E->D||0.01|Benign|0.46|tolerated|MGI:3645854|Sult2a4|sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 4 [Source:MGI Symbol;Acc:MGI:3645854]|Heterozygous||T|A|149|40.0|Non-synonymous|Unprocessed|APF-G1
1787238|IGL00835|10|18661358|F->L||0.15|Benign|0.83|tolerated|MGI:106387|D10bwg1379e|DNA segment, Chr 10, Brigham & Women's Genetics 1379 expressed [Source:MGI Symbol;Acc:MGI:106387]|Heterozygous||A|G|84|39.5|Non-synonymous|Unprocessed|APF-G1
1787239|IGL00835|14|63135650|D->E||0.99|Probably damaging||deleterious|MGI:88561|Ctsb|cathepsin B [Source:MGI Symbol;Acc:MGI:88561]|Heterozygous|Homozygotes for targeted null mutations are born normal without gross abnormalities.  Homozygous mutant has resistance to induced pancreatitis.  In combination with Ctsl<sup>tm1Cptr</sup>, double homozygous mutant shows postnatal lethality due to wide neuronal degeneration in brain.|T|A|71|39.0|Non-synonymous|Unprocessed|APF-G1
1787240|IGL00835|6|12554934|V->G||1.0|Probably damaging||deleterious|MGI:2685683|Thsd7a|thrombospondin, type I, domain containing 7A [Source:MGI Symbol;Acc:MGI:2685683]|Heterozygous||A|C|70|37.5|Non-synonymous|Unprocessed|APF-G1
1787241|IGL00835|17|80216526|C->G||0.99|Probably damaging|0.02|deleterious|MGI:1914987|Ttc39d|tetratricopeptide repeat domain 39D [Source:MGI Symbol;Acc:MGI:1914987]|Heterozygous||T|G|57|40.0|Non-synonymous|Unprocessed|APF-G1
1787242|IGL00835|6|85622134|Y->C|||Unknown|0.12|tolerated|MGI:1934606|Alms1|Alstrom syndrome 1 homolog (human) [Source:MGI Symbol;Acc:MGI:1934606]|Heterozygous|Homozygous null mice display obesity starting after puberty, hypogonadism, hyperinsulinemia, male-specific hyperglycemia, retinal dysfunction, and late-onset hearing loss.|A|G|54|37.5|Non-synonymous|Unprocessed|APF-G1
1787243|IGL00835|16|45751456|T->I||1.0|Probably damaging||deleterious|MGI:2444981|Phldb2|pleckstrin homology-like domain, family B, member 2 [Source:MGI Symbol;Acc:MGI:2444981]|Heterozygous||G|A|50|41.0|Non-synonymous|Unprocessed|APF-G1
1787244|IGL00835|7|35776038|H->N||0.95|Possibly damaging||deleterious|MGI:1916378|Zfp507|zinc finger protein 507 [Source:MGI Symbol;Acc:MGI:1916378]|Heterozygous||G|T|49|38.0|Non-synonymous|Unprocessed|APF-G1
1787245|IGL00835|3|95490340|D->G||0.99|Probably damaging|0.01|deleterious|MGI:88071|Arnt|aryl hydrocarbon receptor nuclear translocator [Source:MGI Symbol;Acc:MGI:88071]|Heterozygous|Homozygotes for targeted null mutations exhibit loss of aryl hydrocarbon receptor and hypoxia-inducible factor 1 alpha gene induction, defective angiogenesis of the yolk sac and branchial arches, placental defects, and lethality by embryonic day 10.5.|A|G|45|39.0|Non-synonymous|Unprocessed|APF-G1
1787246|IGL00835|2|129609183|C->Y||1.0|Probably damaging||deleterious|MGI:108563|Sirpa|signal-regulatory protein alpha [Source:MGI Symbol;Acc:MGI:108563]|Heterozygous|Homozygous null mice display mild thrombocytopenia, fatty livers, decreased body weight, decreased proportion of single positive T cells, enhanced peritoneal macrophage phagocytosis and impaired Langerhans cell migration.|G|A|42|39.5|Non-synonymous|Unprocessed|APF-G1
1787247|IGL00835|6|135733570|S->C||1.0|Probably damaging|0.01|deleterious|MGI:95821|Grin2b|glutamate receptor, ionotropic, NMDA2B (epsilon 2) [Source:MGI Symbol;Acc:MGI:95821]|Heterozygous|Homozygotes for targeted null mutations exhibit impairments in suckling, in hippocampal long term depression, and in pattern formation of trigeminal nucleus sensory afferent terminals. Mutants die shortly after birth.|T|A|41|37.0|Non-synonymous|Unprocessed|APF-G1
1787248|IGL00835|9|15007844|S->P||0.88|Possibly damaging|0.11|tolerated|MGI:1860055|Panx1|pannexin 1 [Source:MGI Symbol;Acc:MGI:1860055]|Heterozygous|Mice homozygous for a knock-out allele exhibit impaired macrophage recruitment, YO-PRO-1 dye uptake, and ATP release by apoptotic thymocytes.|A|G|41|40.0|Non-synonymous|Unprocessed|APF-G1
1787249|IGL00835|11|80047675|T->A|||Benign|0.84|tolerated|MGI:1860086|Crlf3|cytokine receptor-like factor 3 [Source:MGI Symbol;Acc:MGI:1860086]|Heterozygous||T|C|40|39.5|Non-synonymous|Unprocessed|APF-G1
1787250|IGL00835|13|74160302|H->N||0.05|Benign|0.11|tolerated|MGI:105064|Slc9a3|solute carrier family 9 (sodium/hydrogen exchanger), member 3 [Source:MGI Symbol;Acc:MGI:105064]|Heterozygous|Homozygous mutant mice have diarrhea associated with defects of renal and intestinal absorption. Males are infertile.|C|A|40|40.0|Non-synonymous|Unprocessed|APF-G1
1787251|IGL00835|3|90241987|H->L||0.34|Benign|0.61|tolerated|MGI:1916603|Creb3l4|cAMP responsive element binding protein 3-like 4 [Source:MGI Symbol;Acc:MGI:1916603]|Heterozygous|Homozygous null mice display oligozoospermia but have normal fertility and sperm morphology and motility.|T|A|39|39.0|Non-synonymous|Unprocessed|APF-G1
1787252|IGL00835|5|32364172|E->K|||Unknown||deleterious|MGI:1922406|Plb1|phospholipase B1 [Source:MGI Symbol;Acc:MGI:1922406]|Heterozygous||G|A|38|38.5|Non-synonymous|Unprocessed|APF-G1
1787253|IGL00835|7|127920504|D->G||0.25|Benign||deleterious|MGI:1915023|Myst1|MYST histone acetyltransferase 1 [Source:MGI Symbol;Acc:MGI:1915023]|Heterozygous|Mice homozygous for a null allele die prior to gastrulation.|A|G|36|40.0|Non-synonymous|Unprocessed|APF-G1
1787254|IGL00835|8|120010648|R->H||1.0|Probably damaging|0.02|deleterious|MGI:1926142|Crispld2|cysteine-rich secretory protein LCCL domain containing 2 [Source:MGI Symbol;Acc:MGI:1926142]|Heterozygous||G|A|30|35.0|Non-synonymous|Unprocessed|APF-G1
1787255|IGL00835|1|71302733|D->G||1.0|Probably damaging||deleterious|MGI:2676312|Abca12|ATP-binding cassette, sub-family A (ABC1), member 12 [Source:MGI Symbol;Acc:MGI:2676312]|Heterozygous|Mice homozygous for a null allele exhibit neonatal lethality associated with defective skin development and abnormal lung morphology.|T|C|29|40.0|Non-synonymous|Unprocessed|APF-G1
1787256|IGL00835|6|67360567|V->D||1.0|Probably damaging|0.02|deleterious|MGI:1270861|Il12rb2|interleukin 12 receptor, beta 2 [Source:MGI Symbol;Acc:MGI:1270861]|Heterozygous|Mice homozygous for a knock-out allele have defects in IFN-gamma production and cytotoxic T lymphocyte and NK cytotoxicity, develop an autoimmune/lymphoproliferative disorder associated with higher susceptibility to spontaneous tumor formation, but show reduced in vivo growth of B16 melanoma tumors.|A|T|27|39.0|Non-synonymous|Unprocessed|APF-G1
1787257|IGL00835|10|79881052|T->A||0.86|Possibly damaging|0.57|tolerated|MGI:893580|Prtn3|proteinase 3 [Source:MGI Symbol;Acc:MGI:893580]|Heterozygous||A|G|26|39.0|Non-synonymous|Unprocessed|APF-G1
1787258|IGL00835|10|100563380|R->Stop|||N/A|||MGI:2384917|Cep290|centrosomal protein 290 [Source:MGI Symbol;Acc:MGI:2384917]|Heterozygous|Mice homozygous for a spontaneous in-frame deletion display mislocalization of ciliary and phototransduction proteins resulting in early-onset retinal degeneration.|A|T|26|38.5|Non-synonymous|Unprocessed|APF-G1
1787259|IGL00835|6|135244092|M->K||0.02|Benign|0.05|tolerated|MGI:1194499|Gsg1|germ cell-specific gene 1 [Source:MGI Symbol;Acc:MGI:1194499]|Heterozygous||A|T|25|40.0|Non-synonymous|Unprocessed|APF-G1
1787260|IGL00835|1|91115418|T->I||0.99|Probably damaging|0.01|deleterious|MGI:1342770|Lrrfip1|leucine rich repeat (in FLII) interacting protein 1 [Source:MGI Symbol;Acc:MGI:1342770]|Heterozygous||C|T|23|39.0|Non-synonymous|Unprocessed|APF-G1
1787261|IGL00835|13|95362477|V->F||1.0|Probably damaging||deleterious|MGI:1913799|Aggf1|angiogenic factor with G patch and FHA domains 1 [Source:MGI Symbol;Acc:MGI:1913799]|Heterozygous||C|A|23|39.0|Non-synonymous|Unprocessed|APF-G1
1787262|IGL00835|6|34799732|D->G||0.21|Benign|0.05|tolerated|MGI:1923473|Agbl3|ATP/GTP binding protein-like 3 [Source:MGI Symbol;Acc:MGI:1923473]|Heterozygous||A|G|23|40.0|Non-synonymous|Unprocessed|APF-G1
1787263|IGL00835|11|102478549|A->S||0.99|Probably damaging|0.05|deleterious|MGI:1918667|Gpatch8|G patch domain containing 8 [Source:MGI Symbol;Acc:MGI:1918667]|Heterozygous||C|A|21|37.0|Non-synonymous|Unprocessed|APF-G1
1787264|IGL00835|15|91844420|D->V|||Unknown|||MGI:1859618|Smgc|submandibular gland protein C [Source:MGI Symbol;Acc:MGI:1859618]|Heterozygous||A|T|21|38.0|Non-synonymous|Unprocessed|APF-G1
1787265|IGL00835|4|95837628|I->N||0.76|Possibly damaging||deleterious|MGI:1922828|Fggy|FGGY carbohydrate kinase domain containing [Source:MGI Symbol;Acc:MGI:1922828]|Heterozygous||T|A|20|36.0|Non-synonymous|Unprocessed|APF-G1
1787266|IGL00835|6|92242789|E->G||0.9|Possibly damaging|0.2|tolerated|MGI:98823|Trh|thyrotropin releasing hormone [Source:MGI Symbol;Acc:MGI:98823]|Heterozygous|Homozygous null mice exhibit teritary hypothyroidism, elevated TSH levels and hyperglycemia.|T|C|19|39.0|Non-synonymous|Unprocessed|APF-G1
1787267|IGL00835|15|101543378|I->N||0.82|Possibly damaging||deleterious|MGI:2149248|Krt82|keratin 82 [Source:MGI Symbol;Acc:MGI:2149248]|Heterozygous||A|T|18|36.5|Non-synonymous|Unprocessed|APF-G1
1787268|IGL00835|3|26924262|E->V||1.0|Probably damaging||deleterious|MGI:1918112|Spata16|spermatogenesis associated 16 [Source:MGI Symbol;Acc:MGI:1918112]|Heterozygous||A|T|15|38.0|Non-synonymous|Unprocessed|APF-G1
1787269|IGL00835|2|28672466|D->G||0.3|Benign|0.17|tolerated|MGI:1929183|Tsc1|tuberous sclerosis 1 [Source:MGI Symbol;Acc:MGI:1929183]|Heterozygous|Homozygous null mutants show liver hypoplasia, open neural tube and die by embryonic day 10.5-11.5. Heterozygotes develop kidney cystadenomas and liver hemangiomas. Conditional astrocyte-specific nulls show increased astrocyte numbers and seizures.|A|G|14|39.0|Non-synonymous|Unprocessed|APF-G1
1787270|IGL00835|12|4833726|G->S||0.99|Probably damaging|0.08|tolerated|MGI:1336205|Fkbp1b|FK506 binding protein 1b [Source:MGI Symbol;Acc:MGI:1336205]|Heterozygous|Homozygotes for a null allele display exercise-induced sudden cardiac death. Homozygotes for a second null allele show impaired glucose tolerance and glucose-driven insulin secretion. Homozygotes for a third null allele show Ca2+ dysregulation and male-specific cardiac hypertrophy and hypertension.|C|T|13|37.0|Non-synonymous|Unprocessed|APF-G1
1787271|IGL00835|4|134564532|Q->L||1.0|Probably damaging||deleterious|MGI:2446214|Man1c1|mannosidase, alpha, class 1C, member 1 [Source:MGI Symbol;Acc:MGI:2446214]|Heterozygous||T|A|13|39.0|Non-synonymous|Unprocessed|APF-G1
1787272|IGL00835|4|145160652|D->E||0.53|Possibly damaging|0.04|deleterious|MGI:2448530|Vps13d|vacuolar protein sorting 13 D (yeast) [Source:MGI Symbol;Acc:MGI:2448530]|Heterozygous||A|T|12|39.0|Non-synonymous|Unprocessed|APF-G1
1787273|IGL00835|7|30633667|D->E||0.22|Benign|0.21|tolerated|MGI:99253|Etv2|ets variant gene 2 [Source:MGI Symbol;Acc:MGI:99253]|Heterozygous|Mice homozygous for null alleles die during organogenesis and lack blood vessels. In addition mice homozygous for one allele lack endocardial cells, while mice homozygous for another allele lack blood cells.|A|T|12|35.5|Non-synonymous|Unprocessed|APF-G1
1787274|IGL00835|18|35214239|L->F||0.1|Benign|0.37|tolerated|MGI:88274, MGI:2389174|Ctnna1,lrrtm2|leucine rich repeat transmembrane neuronal 2 [Source:MGI Symbol;Acc:MGI:2389174],catenin (cadherin associated protein), alpha 1 [Source:MGI Symbol;Acc:MGI:88274]|Heterozygous|NO_PHENOTYPE,Homozygous mutation of this gene results in embryonic lethality at the blastocyst stage. A conditional knockout in surface epithelium results in defects in hair follicle development and epidermal morphogenesis.|T|A|10|39.0|Non-synonymous|Unprocessed|APF-G1
1787279|IGL00835|12|98747524|Disrupted splicing||||||MGI:1919824|Zc3h14|zinc finger CCCH type containing 14 [Source:MGI Symbol;Acc:MGI:1919824]|Heterozygous||T|A|45|38.0|Splice|Unprocessed|APF-G1
1787280|IGL00835|10|56089846|Disrupted splicing||||||MGI:2442827|D630037f22rik|RIKEN cDNA D630037F22 gene [Source:MGI Symbol;Acc:MGI:2442827]|Heterozygous|Mice homozygous for a gene trap allele or ENU induced mutation exhibit exencephaly and poor eye development.|A|G|31|40.0|Splice|Unprocessed|APF-G1
1787281|IGL00835|4|126757071|Disrupted splicing||||||MGI:2140475|Au040320|expressed sequence AU040320 [Source:MGI Symbol;Acc:MGI:2140475]|Heterozygous||A|G|26|37.0|Splice|Unprocessed|APF-G1
1787282|IGL00835|12|103141890|Disrupted splicing||||||MGI:2684729|Unc79|unc-79 homolog (C. elegans) [Source:MGI Symbol;Acc:MGI:2684729]|Heterozygous||T|G|24|35.0|Splice|Unprocessed|APF-G1
1787283|IGL00835|1|128235632|Disrupted splicing||||||MGI:2448514|R3hdm1|R3H domain 1 (binds single-stranded nucleic acids) [Source:MGI Symbol;Acc:MGI:2448514]|Heterozygous||T|C|23|39.0|Splice|Unprocessed|APF-G1
1787284|IGL00835|8|55940977|Disrupted splicing||||||MGI:95749|Glra3|glycine receptor, alpha 3 subunit [Source:MGI Symbol;Acc:MGI:95749]|Heterozygous|Homozygous null mice are fertile and display decreased inflammatory pain sensitization without any gross abnormalities in the brain or spinal cord.|A|G|23|40.0|Splice|Unprocessed|APF-G1
1787759|IGL00836|7|27910890|E->G|||Benign|0.31|tolerated|MGI:1920680|1700049g17rik|RIKEN cDNA 1700049G17 gene [Source:MGI Symbol;Acc:MGI:1920680]|Heterozygous||T|C|72|39.0|Non-synonymous|Unprocessed|APF-G1
1787761|IGL00836|6|57619549|M->I||0.98|Probably damaging|0.04|deleterious|MGI:1914388|Herc6|hect domain and RLD 6 [Source:MGI Symbol;Acc:MGI:1914388]|Heterozygous||G|A|67|40.0|Non-synonymous|Unprocessed|APF-G1
1787762|IGL00836|6|130327144|I->N||0.99|Probably damaging|0.29|tolerated|MGI:101905|Klra3|killer cell lectin-like receptor, subfamily A, member 3 [Source:MGI Symbol;Acc:MGI:101905]|Heterozygous||A|T|66|39.0|Non-synonymous|Unprocessed|APF-G1
1787763|IGL00836|9|95761422|V->A||0.73|Possibly damaging||deleterious|MGI:104809|Pls1|plastin 1 (I-isoform) [Source:MGI Symbol;Acc:MGI:104809]|Heterozygous||A|G|63|38.0|Non-synonymous|Unprocessed|APF-G1
1787764|IGL00836|18|53216400|M->K||0.13|Benign|0.01|deleterious|MGI:1915054|Snx2|sorting nexin 2 [Source:MGI Symbol;Acc:MGI:1915054]|Heterozygous|Homozygous mutant mice are viable and fertile and do not exhibit any apparent abnormalities.|T|A|57|40.0|Non-synonymous|Unprocessed|APF-G1
1787765|IGL00836|4|129182108|N->K||0.06|Benign|0.28|tolerated|MGI:1921898|S100pbp|S100P binding protein [Source:MGI Symbol;Acc:MGI:1921898]|Heterozygous||A|T|55|39.0|Non-synonymous|Unprocessed|APF-G1
1787766|IGL00836|14|51145546|Y->F||0.23|Benign|0.09|tolerated|MGI:97919|Rnase1|ribonuclease, RNase A family, 1 (pancreatic) [Source:MGI Symbol;Acc:MGI:97919]|Heterozygous||T|A|49|38.0|Non-synonymous|Unprocessed|APF-G1
1787767|IGL00836|11|106852636|Y->H|||Benign|0.56|tolerated|MGI:1913563|Smurf2|SMAD specific E3 ubiquitin protein ligase 2 [Source:MGI Symbol;Acc:MGI:1913563]|Heterozygous|Mice homozygous for a null allele are viable and only display gastrulation defects in combination with a Smurf1 knock-out allele.|A|G|45|39.0|Non-synonymous|Unprocessed|APF-G1
1787768|IGL00836|9|50604994|D->G||0.76|Possibly damaging|0.15|tolerated|MGI:1353424|Timm8b|translocase of inner mitochondrial membrane 8 homolog b (yeast) [Source:MGI Symbol;Acc:MGI:1353424]|Heterozygous||A|G|37|37.0|Non-synonymous|Unprocessed|APF-G1
1787769|IGL00836|16|37208100|S->T||0.77|Possibly damaging|0.06|tolerated|MGI:2443815|Stxbp5l|syntaxin binding protein 5-like [Source:MGI Symbol;Acc:MGI:2443815]|Heterozygous||A|T|32|39.0|Non-synonymous|Unprocessed|APF-G1
1787770|IGL00836|8|116514833|T->A||0.3|Benign|0.24|tolerated|MGI:1922715|Dynlrb2|dynein light chain roadblock-type 2 [Source:MGI Symbol;Acc:MGI:1922715]|Heterozygous||A|G|32|38.0|Non-synonymous|Unprocessed|APF-G1
1787771|IGL00836|18|23597488|S->P|||Benign|0.56|tolerated|MGI:106039|Dtna|dystrobrevin alpha [Source:MGI Symbol;Acc:MGI:106039]|Heterozygous|Homozygous targeted mutants exhibit skeletal and cardiac myopathies.  Neuromuscular junctions appear to form normally, but their postnatal maturation is compromised. Dtna mutations do not increase the severity of Dmd or Utrn mutants whose products are also part of the dystrophin-glycoprotein complex.|T|C|28|31.5|Non-synonymous|Unprocessed|APF-G1
1787772|IGL00836|5|108180525|S->N||0.04|Benign|0.56|tolerated|MGI:1922974|Ccdc18|coiled-coil domain containing 18 [Source:MGI Symbol;Acc:MGI:1922974]|Heterozygous||G|A|26|40.0|Non-synonymous|Unprocessed|APF-G1
1787773|IGL00836|19|39324990|D->G||1.0|Probably damaging||deleterious|MGI:103238|Cyp2c29|cytochrome P450, family 2, subfamily c, polypeptide 29 [Source:MGI Symbol;Acc:MGI:103238]|Heterozygous||A|G|19|37.0|Non-synonymous|Unprocessed|APF-G1
1787774|IGL00836|4|48158955|S->P||0.02|Benign|0.3|tolerated|MGI:1914977|Stx17|syntaxin 17 [Source:MGI Symbol;Acc:MGI:1914977]|Heterozygous||T|C|18|38.0|Non-synonymous|Unprocessed|APF-G1
1787775|IGL00836|3|28718741|A->T||1.0|Probably damaging|0.07|tolerated|MGI:1095438|Slc2a2|solute carrier family 2 (facilitated glucose transporter), member 2 [Source:MGI Symbol;Acc:MGI:1095438]|Heterozygous|Homozygous null mice are hyperglycemic with hypoinsulinemia and die within 2-3 weeks of life displaying increased plasma levels of glucagon, free fatty acids and beta-hydroxybutyrate, abnormal glucose tolerance, and altered postnatal development of pancreatic islets.|G|A|15|39.0|Non-synonymous|Unprocessed|APF-G1
1787776|IGL00836|18|12472228|I->V|||Benign|1.0|tolerated|MGI:99909|Lama3|laminin, alpha 3 [Source:MGI Symbol;Acc:MGI:99909]|Heterozygous|Mice homozygous for a targeted null mutation develop a lethal blistering phenotype similar to human junctional epidermolysis bullosa, and die 2-3 days after birth from a failure to thrive.|A|G|14|39.0|Non-synonymous|Unprocessed|APF-G1
1787777|IGL00836|17|32941164|H->Y|||Benign|0.02|deleterious|MGI:2158641|Cyp4f13|cytochrome P450, family 4, subfamily f, polypeptide 13 [Source:MGI Symbol;Acc:MGI:2158641]|Heterozygous||G|A|13|39.0|Non-synonymous|Unprocessed|APF-G1
1787778|IGL00836|14|28040521|I->T||1.0|Probably damaging|0.03|deleterious|MGI:1098749|Erc2|ELKS/RAB6-interacting/CAST family member 2 [Source:MGI Symbol;Acc:MGI:1098749]|Heterozygous|Mice homozygous for a targeted disruption of this gene are viable and fertile. However, evoked inhibitory postsynaptic currents (IPSCs), evoked charge transfer, and the readily releasable pool measured by sucrose are moderately increased relative to wild-type controls.|T|C|11|38.0|Non-synonymous|Unprocessed|APF-G1
1787779|IGL00836|7|130759168|D->G||0.07|Benign|0.06|tolerated|MGI:1928899|Tacc2|transforming, acidic coiled-coil containing protein 2 [Source:MGI Symbol;Acc:MGI:1928899]|Heterozygous|Homozygous null mice are healthy and fertile and do not display any increase in tumorigenesis.|A|G|10|38.5|Non-synonymous|Unprocessed|APF-G1
1787780|IGL00836|16|18827718|Disrupted splicing||||||MGI:109353|Ufd1l|ubiquitin fusion degradation 1 like [Source:MGI Symbol;Acc:MGI:109353]|Heterozygous|Mice heterozygous for a knock-out allele are viable with no obvious heart defects.|G|T|38|40.0|Splice|Unprocessed|APF-G1
1787781|IGL00836|9|31329869|Disrupted splicing||||||MGI:2682952|Prdm10|PR domain containing 10 [Source:MGI Symbol;Acc:MGI:2682952]|Heterozygous||C|A|24|38.0|Splice|Unprocessed|APF-G1
1787782|IGL00836|9|57107345|Disrupted splicing||||||MGI:107157|Sin3a|transcriptional regulator, SIN3A (yeast) [Source:MGI Symbol;Acc:MGI:107157]|Heterozygous|Targeted disruption of this gene results in early embryonic lethality. Homozygous null MEFs display poor cell proliferation, reduced S-phase and increased G2/M fractions, a block in DNA replication, and enhanced apoptosis; however, no increase in chromosomal instability is observed.|T|A|24|38.0|Splice|Unprocessed|APF-G1
1788237|IGL00837|1|155953391|S->T||0.9|Possibly damaging|0.19|tolerated|MGI:1921331|Cep350|centrosomal protein 350 [Source:MGI Symbol;Acc:MGI:1921331]|Heterozygous||A|T|92|38.0|Non-synonymous|Unprocessed|APF-G1
1788238|IGL00837|11|70321054|T->A|||Benign|0.79|tolerated|MGI:1274790|Alox12e|arachidonate lipoxygenase, epidermal [Source:MGI Symbol;Acc:MGI:1274790]|Heterozygous||T|C|92|39.0|Non-synonymous|Unprocessed|APF-G1
1788239|IGL00837|9|114330492|T->S||0.1|Benign|0.55|tolerated|MGI:1278327|Bcl2a1c|B-cell leukemia/lymphoma 2 related protein A1c [Source:MGI Symbol;Acc:MGI:1278327]|Heterozygous||A|T|79|38.0|Non-synonymous|Unprocessed|APF-G1
1788240|IGL00837|3|19144420|N->K||0.02|Benign|0.94|tolerated|MGI:1921502|Armc1|armadillo repeat containing 1 [Source:MGI Symbol;Acc:MGI:1921502]|Heterozygous||A|C|74|39.0|Non-synonymous|Unprocessed|APF-G1
1788241|IGL00837|19|59284384|I->F||0.9|Possibly damaging|0.16|tolerated|MGI:106677|Slc18a2|solute carrier family 18 (vesicular monoamine), member 2 [Source:MGI Symbol;Acc:MGI:106677]|Heterozygous||A|T|70|38.0|Non-synonymous|Unprocessed|APF-G1
1788242|IGL00837|10|121296845|I->V||0.39|Benign|0.27|tolerated|MGI:1921944|Tbc1d30|TBC1 domain family, member 30 [Source:MGI Symbol;Acc:MGI:1921944]|Heterozygous||T|C|65|38.0|Non-synonymous|Unprocessed|APF-G1
1788243|IGL00837|14|60280217|Y->Stop|||N/A|||MGI:2145637|Mtmr6|myotubularin related protein 6 [Source:MGI Symbol;Acc:MGI:2145637]|Heterozygous||T|A|65|38.0|Non-synonymous|Unprocessed|APF-G1
1788244|IGL00837|12|75633051|L->Stop|||N/A|||MGI:1919588|Wdr89|WD repeat domain 89 [Source:MGI Symbol;Acc:MGI:1919588]|Heterozygous||A|T|48|39.0|Non-synonymous|Unprocessed|APF-G1
1788245|IGL00837|12|87077197|S->N|||Benign|0.11|tolerated|MGI:2444386|Tmem63c|transmembrane protein 63c [Source:MGI Symbol;Acc:MGI:2444386]|Heterozygous||G|A|44|40.0|Non-synonymous|Unprocessed|APF-G1
1788246|IGL00837|2|161042079|N->S|||Benign|0.78|tolerated|MGI:1918639|Chd6|chromodomain helicase DNA binding protein 6 [Source:MGI Symbol;Acc:MGI:1918639]|Heterozygous|Homozygous null mice display impaired coordination that is not due to muscle weakness or bradykinesia.|T|C|43|38.0|Non-synonymous|Unprocessed|APF-G1
1788247|IGL00837|15|19013404|I->L|||Benign|1.0|tolerated|MGI:107436|Cdh10|cadherin 10 [Source:MGI Symbol;Acc:MGI:107436]|Heterozygous||A|T|40|34.0|Non-synonymous|Unprocessed|APF-G1
1788248|IGL00837|1|19119206|D->V||0.81|Possibly damaging|0.03|deleterious|MGI:2153466|Tcfap2d|transcription factor AP-2, delta [Source:MGI Symbol;Acc:MGI:2153466]|Heterozygous||A|T|33|38.0|Non-synonymous|Unprocessed|APF-G1
1788249|IGL00837|2|158502789|F->Y||0.05|Benign||deleterious|MGI:2675492|Adig|adipogenin [Source:MGI Symbol;Acc:MGI:2675492]|Heterozygous||T|A|32|37.0|Non-synonymous|Unprocessed|APF-G1
1788250|IGL00837|10|31503774|L->P||0.98|Probably damaging||deleterious|MGI:3610311|Rnf217|ring finger protein 217 [Source:MGI Symbol;Acc:MGI:3610311]|Heterozygous||A|G|30|39.5|Non-synonymous|Unprocessed|APF-G1
1788251|IGL00837|5|110302009|V->E||0.99|Probably damaging|0.84|tolerated|MGI:1196391|Pole|polymerase (DNA directed), epsilon [Source:MGI Symbol;Acc:MGI:1196391]|Heterozygous|Mice homozygous for a null allele exhibit increased incidence of tumors and premature death.|T|A|26|37.0|Non-synonymous|Unprocessed|APF-G1
1788252|IGL00837|16|33807959|K->Stop|||N/A|||MGI:103190|Muc13|mucin 13, epithelial transmembrane [Source:MGI Symbol;Acc:MGI:103190]|Heterozygous||A|T|21|41.0|Non-synonymous|Unprocessed|APF-G1
1788253|IGL00837|6|48908664|I->N||0.06|Benign||deleterious|MGI:1923757|Abp1|amiloride binding protein 1 (amine oxidase, copper-containing) [Source:MGI Symbol;Acc:MGI:1923757]|Heterozygous||T|A|14|36.0|Non-synonymous|Unprocessed|APF-G1
1788257|IGL00837|16|91638720|Disrupted splicing||||||MGI:95654|Gart|phosphoribosylglycinamide formyltransferase [Source:MGI Symbol;Acc:MGI:95654]|Heterozygous||T|C|104|38.0|Splice|Unprocessed|APF-G1
1788258|IGL00837|4|120781547|Disrupted splicing||||||MGI:107901|Nfyc|nuclear transcription factor-Y gamma [Source:MGI Symbol;Acc:MGI:107901]|Heterozygous||A|G|86|40.0|Splice|Unprocessed|APF-G1
1788259|IGL00837|1|156006916|Disrupted splicing||||||MGI:3582693|Tor1aip1|torsin A interacting protein 1 [Source:MGI Symbol;Acc:MGI:3582693]|Heterozygous||T|A|78|37.0|Splice|Unprocessed|APF-G1
1788260|IGL00837|10|40254474|Disrupted splicing||||||MGI:1914621|Gtf3c6|general transcription factor IIIC, polypeptide 6, alpha [Source:MGI Symbol;Acc:MGI:1914621]|Heterozygous||A|G|43|37.0|Splice|Unprocessed|APF-G1
1788261|IGL00837|7|68201352|Disrupted splicing||||||MGI:96433|Igf1r|insulin-like growth factor I receptor [Source:MGI Symbol;Acc:MGI:96433]|Heterozygous|Targeted null mutants die at birth of respiratory failure; fetuses exhibit retarded growth, organ hypoplasia, ossification delay and nervous system and epidermal abnormalities. hyft homozygous fetuses are growth retarded and exhibit hydrops fetalis and focal hepatic ischemia.|T|C|32|36.0|Splice|Unprocessed|APF-G1
1788262|IGL00837|1|37801911|Disrupted splicing||||||MGI:2685063|Tsga10|testis specific 10 [Source:MGI Symbol;Acc:MGI:2685063]|Heterozygous||A|C|29|40.0|Splice|Unprocessed|APF-G1
1788263|IGL00837|2|66235571|Disrupted splicing||||||MGI:1920918|Ttc21b|tetratricopeptide repeat domain 21B [Source:MGI Symbol;Acc:MGI:1920918]|Heterozygous|Homozygous mutation of this gene is embryonic lethal. Mutant embryos exhibit several deformities including polydactyly, microphthalmia, irregular shape of the long bones, rib fusion and truncation, neural tube defects, and abnormal brain structure.|A|T|20|38.5|Splice|Unprocessed|APF-G1
1788264|IGL00837|11|72755898|Disrupted splicing||||||MGI:1337008|Ankfy1|ankyrin repeat and FYVE domain containing 1 [Source:MGI Symbol;Acc:MGI:1337008]|Heterozygous||T|A|17|35.0|Splice|Unprocessed|APF-G1
1788265|IGL00837|4|111893690|Disrupted splicing||||||MGI:2140201|Slc5a9|solute carrier family 5 (sodium/glucose cotransporter), member 9 [Source:MGI Symbol;Acc:MGI:2140201]|Heterozygous||A|G|17|40.0|Splice|Unprocessed|APF-G1
1788266|IGL00837|6|55461620|Disrupted splicing||||||MGI:108449|Adcyap1r1|adenylate cyclase activating polypeptide 1 receptor 1 [Source:MGI Symbol;Acc:MGI:108449]|Heterozygous|Homozygotes for targeted mutations affect contextual fear conditioning, elevated locomotor activity, anxiety-like behavior, susceptibility to endotoxic shock, circadian responses to a photic stimulus, and glucose tolerance. Some alleles affect female fertility.|T|C|15|39.0|Splice|Unprocessed|APF-G1
1788730|IGL00838|6|129911359|G->C||0.89|Possibly damaging|0.07|tolerated|MGI:101903|Klra5|killer cell lectin-like receptor, subfamily A, member 5 [Source:MGI Symbol;Acc:MGI:101903]|Heterozygous|Mice homozygous for a knock-out allele exhibit normal NK and T cell morphology and function.|C|A|188|40.0|Non-synonymous|Unprocessed|APF-G1
1788731|IGL00838|6|129054316|V->I||0.83|Possibly damaging|0.01|deleterious|MGI:2442965|Klrb1f|killer cell lectin-like receptor subfamily B member 1F [Source:MGI Symbol;Acc:MGI:2442965]|Heterozygous||G|A|174|40.0|Non-synonymous|Unprocessed|APF-G1
1788732|IGL00838|X|100972118|I->N||0.91|Possibly damaging|0.02|deleterious|MGI:1933237|Tex11|testis expressed gene 11 [Source:MGI Symbol;Acc:MGI:1933237]|Heterozygous|Miche homozygous for a knockout allele exhibit abnormal male meiosis.  Mice homozygous for a conditional knockout exhibit male infertility and reduced female fecundity due to abnormal meiosis following cre recombination.|A|T|165|40.0|Non-synonymous|Unprocessed|APF-G1
1788733|IGL00838|13|11568503|I->N||1.0|Probably damaging||deleterious|MGI:99685|Ryr2|ryanodine receptor 2, cardiac [Source:MGI Symbol;Acc:MGI:99685]|Heterozygous|Mice homozygous for a null mutation display embryonic lethality during organogenesis and abnormal cardiomyocyte morphology. Mice homozygous for a phosphorylation defective allele display decreased susceptibility to myocardial infarction-induced heart failure.|A|T|68|39.0|Non-synonymous|Unprocessed|APF-G1
1788734|IGL00838|4|49490352|M->K||1.0|Probably damaging||deleterious|MGI:106642|Baat|bile acid-Coenzyme A: amino acid N-acyltransferase [Source:MGI Symbol;Acc:MGI:106642]|Heterozygous||A|T|60|40.0|Non-synonymous|Unprocessed|APF-G1
1788735|IGL00838|3|154618475|C->S||0.92|Possibly damaging|0.01|deleterious|MGI:88527|Cryz|crystallin, zeta [Source:MGI Symbol;Acc:MGI:88527]|Heterozygous||T|A|56|39.0|Non-synonymous|Unprocessed|APF-G1
1788736|IGL00838|5|21661581|V->E||1.0|Probably damaging||deleterious|MGI:1914461|Armc10|armadillo repeat containing 10 [Source:MGI Symbol;Acc:MGI:1914461]|Heterozygous||T|A|54|38.5|Non-synonymous|Unprocessed|APF-G1
1788737|IGL00838|1|93402757|N->K||0.98|Probably damaging|0.03|deleterious|MGI:3052714|Ano7|anoctamin 7 [Source:MGI Symbol;Acc:MGI:3052714]|Heterozygous||C|A|50|37.5|Non-synonymous|Unprocessed|APF-G1
1788738|IGL00838|3|103625626|M->K||0.6|Possibly damaging||deleterious|MGI:1859544|Syt6|synaptotagmin VI [Source:MGI Symbol;Acc:MGI:1859544]|Heterozygous||T|A|42|37.0|Non-synonymous|Unprocessed|APF-G1
1788739|IGL00838|13|76134791|L->P||||0.08|tolerated|MGI:2679923|Ttc37|tetratricopeptide repeat domain 37 [Source:MGI Symbol;Acc:MGI:2679923]|Heterozygous||T|C|38|39.0|Non-synonymous|Unprocessed|APF-G1
1788740|IGL00838|14|24475863|N->K||0.69|Possibly damaging|0.13|tolerated|MGI:2681836|Polr3a|polymerase (RNA) III (DNA directed) polypeptide A [Source:MGI Symbol;Acc:MGI:2681836]|Heterozygous||A|T|35|38.0|Non-synonymous|Unprocessed|APF-G1
1788741|IGL00838|19|25175459|R->Stop|||N/A|||MGI:1921396|Dock8|dedicator of cytokinesis 8 [Source:MGI Symbol;Acc:MGI:1921396]|Heterozygous|Mice homozygous for inactivating mutations of this gene exhibit loss of marginal zone B cells, decrease in peritoneal B1 cells and peripheral naive T cells, failure of sustained antibody response after immunization, failure of germinal center persistence, and failure of B cell affinity maturation.|A|T|35|39.0|Non-synonymous|Unprocessed|APF-G1
1788742|IGL00838|4|100333743|V->G||0.96|Probably damaging|0.39|tolerated|MGI:1347520|Ror1|receptor tyrosine kinase-like orphan receptor 1 [Source:MGI Symbol;Acc:MGI:1347520]|Heterozygous|Mice homozygous for disruptions in this gene die within the first day after birth from respiratory defects.|T|G|33|37.0|Non-synonymous|Unprocessed|APF-G1
1788743|IGL00838|2|104201303|K->N||1.0|Probably damaging||deleterious|MGI:2181743|D430041d05rik|RIKEN cDNA D430041D05 gene [Source:MGI Symbol;Acc:MGI:2181743]|Heterozygous||T|A|30|39.5|Non-synonymous|Unprocessed|APF-G1
1788744|IGL00838|9|74155129|E->V||1.0|Probably damaging|0.01|deleterious|MGI:3583957|Wdr72|WD repeat domain 72 [Source:MGI Symbol;Acc:MGI:3583957]|Heterozygous||A|T|27|39.0|Non-synonymous|Unprocessed|APF-G1
1788745|IGL00838|11|70134212|M->L|||Benign|1.0|tolerated|MGI:2385729|Mgl2|macrophage galactose N-acetyl-galactosamine specific lectin 2 [Source:MGI Symbol;Acc:MGI:2385729]|Heterozygous||A|T|24|38.5|Non-synonymous|Unprocessed|APF-G1
1788746|IGL00838|6|87588693|T->A||0.05|Benign|0.52|tolerated|MGI:1929676|Prokr1|prokineticin receptor 1 [Source:MGI Symbol;Acc:MGI:1929676]|Heterozygous|Mice homozygous for one null allele exhibit abnormal nociceptions and hypoalgesia.  Mice homozygous for another null allele exhibit decreased capillary density in the heart.|T|C|21|37.0|Non-synonymous|Unprocessed|APF-G1
1788747|IGL00838|3|107897558|N->S|||Benign|0.01|deleterious|MGI:1309466|Gstm5|glutathione S-transferase, mu 5 [Source:MGI Symbol;Acc:MGI:1309466]|Heterozygous||A|G|19|38.0|Non-synonymous|Unprocessed|APF-G1
1788748|IGL00838|4|43021767|A->T||0.83|Possibly damaging|0.6|tolerated|MGI:1861452|Pigo|phosphatidylinositol glycan anchor biosynthesis, class O [Source:MGI Symbol;Acc:MGI:1861452]|Heterozygous||C|T|15|37.0|Non-synonymous|Unprocessed|APF-G1
1788749|IGL00838|10|23900779|F->L||1.0|Probably damaging||deleterious|MGI:108395|Vnn1|vanin 1 [Source:MGI Symbol;Acc:MGI:108395]|Heterozygous|Mice homozygous for disruptions of this gene develop normally and so no abnormalities in the maturation of lymphoid organs.  However, membrane bound pantetheinase is absent in livers and kidneys resuulting in an absence of cysteamine in these organs.|T|C|14|37.5|Non-synonymous|Unprocessed|APF-G1
1788750|IGL00838|16|31989173|D->G||0.62|Possibly damaging||deleterious|MGI:2443596|Senp5|SUMO/sentrin specific peptidase 5 [Source:MGI Symbol;Acc:MGI:2443596]|Heterozygous||T|C|13|37.0|Non-synonymous|Unprocessed|APF-G1
1788751|IGL00838|6|83338331|R->C||1.0|Probably damaging||deleterious|MGI:2442631|Mobkl1b|MOB1, Mps One Binder kinase activator-like 1B (yeast) [Source:MGI Symbol;Acc:MGI:2442631]|Heterozygous||C|T|11|39.0|Non-synonymous|Unprocessed|APF-G1
1788752|IGL00838|1|75410390|I->V||0.99|Probably damaging|0.04|deleterious|MGI:109282|Speg|SPEG complex locus [Source:MGI Symbol;Acc:MGI:109282]|Heterozygous|Mice homozygous for a knock-out allele die during the early postnatal period with enlarged, dilated hearts, and decreased cardiac function.|A|G|10|36.5|Non-synonymous|Unprocessed|APF-G1
1788757|IGL00838|6|149005363|Disrupted splicing||||||MGI:2444273|Dennd5b|DENN/MADD domain containing 5B [Source:MGI Symbol;Acc:MGI:2444273]|Heterozygous||T|C|13|40.0|Splice|Unprocessed|APF-G1
1789228|IGL00839|5|3850017|D->E|||Benign|1.0|tolerated|MGI:3045299|4932412h11rik|RIKEN cDNA 4932412H11 gene [Source:MGI Symbol;Acc:MGI:3045299]|Heterozygous||T|A|106|40.0|Non-synonymous|Unprocessed|APF-G1
1789229|IGL00839|X|163926955|Y->C|||||deleterious|MGI:1889383|Ap1s2|adaptor-related protein complex 1, sigma 2 subunit [Source:MGI Symbol;Acc:MGI:1889383]|Heterozygous||A|G|106|39.0|Non-synonymous|Unprocessed|APF-G1
1789230|IGL00839|X|76397349|C->S||1.0|Probably damaging||deleterious|MGI:3588232|4930428d18rik|RIKEN cDNA 4930428D18 gene [Source:MGI Symbol;Acc:MGI:3588232]|Heterozygous||T|A|83|38.0|Non-synonymous|Unprocessed|APF-G1
1789231|IGL00839|16|56000602|Y->Stop|||N/A|||MGI:1915443|Rpl24|ribosomal protein L24 [Source:MGI Symbol;Acc:MGI:1915443]|Heterozygous|Heterozygous mutants have short kinked tail, ventral spotting, malocclusion, white feet, and anomalies of the spine and eyes; homozygotes die in utero.|T|A|81|39.0|Non-synonymous|Unprocessed|APF-G1
1789232|IGL00839|4|143812723|T->A||0.99|Probably damaging|0.07|tolerated|MGI:3650237|Gm13084|predicted gene 13084 [Source:MGI Symbol;Acc:MGI:3650237]|Heterozygous||T|C|78|38.0|Non-synonymous|Unprocessed|APF-G1
1789233|IGL00839|X|142339952|N->K||0.77|Possibly damaging|0.01|deleterious|MGI:1354713|Acsl4|acyl-CoA synthetase long-chain family member 4 [Source:MGI Symbol;Acc:MGI:1354713]|Heterozygous|Female heterozygotes for a targeted null mutation exhibit accumulation of prostaglandins in the uterus, reduced fertility with few and small litters, and very low transmission of the mutant allele.|A|T|65|39.0|Non-synonymous|Unprocessed|APF-G1
1789234|IGL00839|10|111291510|S->R||0.02|Benign|0.55|tolerated|MGI:2443807|Osbpl8|oxysterol binding protein-like 8 [Source:MGI Symbol;Acc:MGI:2443807]|Heterozygous||T|A|64|39.0|Non-synonymous|Unprocessed|APF-G1
1789235|IGL00839|2|132251420|V->I|||Benign|0.28|tolerated|MGI:97503|Pcna|proliferating cell nuclear antigen [Source:MGI Symbol;Acc:MGI:97503]|Heterozygous||C|T|62|38.0|Non-synonymous|Unprocessed|APF-G1
1789236|IGL00839|7|18722968|I->V|||Benign|0.21|tolerated|MGI:1891354|Psg22|pregnancy-specific glycoprotein 22 [Source:MGI Symbol;Acc:MGI:1891354]|Heterozygous||A|G|61|38.0|Non-synonymous|Unprocessed|APF-G1
1789237|IGL00839|3|116546114|G->S||0.02|Benign|0.14|tolerated|MGI:105386|Dbt|dihydrolipoamide branched chain transacylase E2 [Source:MGI Symbol;Acc:MGI:105386]|Heterozygous|Homozygous mutation of this gene results in postnatal lethality, pallor, respiratory distress, and an increase in branched-chain amino acids in the blood and urine. Homozygotes model Maple Syrup Urine Disease.|G|A|60|40.0|Non-synonymous|Unprocessed|APF-G1
1789238|IGL00839|19|29301647|P->S||1.0|Probably damaging||deleterious|MGI:96629|Jak2|Janus kinase 2 [Source:MGI Symbol;Acc:MGI:96629]|Heterozygous|Homozygotes for null mutations die during midgestation due to a failure of erythropoieses.  Mice expressing a conditional allele activated in mammary tissue exhibit lactation deficiency due to impaired alveologenesis. Mice homozygous for a knock-in allele exhibit myeloproliferative neoplasm.|C|T|56|39.5|Non-synonymous|Unprocessed|APF-G1
1789239|IGL00839|3|103099694|E->G||0.69|Possibly damaging||deleterious|MGI:88015|Ampd1|adenosine monophosphate deaminase 1 [Source:MGI Symbol;Acc:MGI:88015]|Heterozygous||A|G|51|40.0|Non-synonymous|Unprocessed|APF-G1
1789240|IGL00839|5|124010751|T->A||1.0|Probably damaging|0.02|deleterious|MGI:1916724|Vps37b|vacuolar protein sorting 37B (yeast) [Source:MGI Symbol;Acc:MGI:1916724]|Heterozygous||T|C|50|38.0|Non-synonymous|Unprocessed|APF-G1
1789241|IGL00839|4|136011359|R->C||1.0|Probably damaging||deleterious|MGI:1351315|Tceb3|transcription elongation factor B (SIII), polypeptide 3 [Source:MGI Symbol;Acc:MGI:1351315]|Heterozygous|Embryos homozygous for a knock-out allele are severely growth retarded, exhibit a wide range of developmental anomalies and die between E10.5 and E12.5, most likely due to massive apoptosis while mutant MEFs show increased apoptosis and senescence-like growth defects.|G|A|38|37.0|Non-synonymous|Unprocessed|APF-G1
1789242|IGL00839|8|21734697|L->H||1.0|Probably damaging||deleterious|MGI:3630383|Defa24|defensin, alpha, 24 [Source:MGI Symbol;Acc:MGI:3630383]|Heterozygous||T|A|36|39.0|Non-synonymous|Unprocessed|APF-G1
1789243|IGL00839|5|149618454|A->D||0.91|Possibly damaging|0.29|tolerated|MGI:105053|Hsph1|heat shock 105kDa/110kDa protein 1 [Source:MGI Symbol;Acc:MGI:105053]|Heterozygous||G|T|33|40.0|Non-synonymous|Unprocessed|APF-G1
1789244|IGL00839|1|17621523|H->R||1.0|Probably damaging||deleterious|MGI:1934659|Pi15|peptidase inhibitor 15 [Source:MGI Symbol;Acc:MGI:1934659]|Heterozygous||A|G|27|37.0|Non-synonymous|Unprocessed|APF-G1
1789245|IGL00839|14|32660916|S->T||0.91|Possibly damaging|0.08|tolerated|MGI:3588196|3425401b19rik|RIKEN cDNA 3425401B19 gene [Source:MGI Symbol;Acc:MGI:3588196]|Heterozygous||A|T|27|39.0|Non-synonymous|Unprocessed|APF-G1
1789246|IGL00839|3|83043291|R->S||0.28|Benign|0.03|deleterious|MGI:99501|Fgb|fibrinogen beta chain [Source:MGI Symbol;Acc:MGI:99501]|Heterozygous||T|A|27|35.0|Non-synonymous|Unprocessed|APF-G1
1789247|IGL00839|6|114480322|T->I||0.99|Probably damaging|0.01|deleterious|MGI:107619|Hrh1|histamine receptor H1 [Source:MGI Symbol;Acc:MGI:107619]|Heterozygous|Homozygous null mutants show decrease in exploratory behavior, diurnal activity, aggression, anxiety, serotonin release, respiratory reaction to temperature and leptin response. Natural variants affect B. pertussis induced vasoactive amine sensitization.|C|T|26|39.0|Non-synonymous|Unprocessed|APF-G1
1789248|IGL00839|6|118405291|V->M|||Benign|0.21|tolerated|MGI:2446132|Bms1|BMS1 homolog, ribosome assembly protein (yeast) [Source:MGI Symbol;Acc:MGI:2446132]|Heterozygous||C|T|26|37.0|Non-synonymous|Unprocessed|APF-G1
1789249|IGL00839|8|3542299|D->G||0.58|Possibly damaging|0.06|tolerated|MGI:1354723|Pnpla6|patatin-like phospholipase domain containing 6 [Source:MGI Symbol;Acc:MGI:1354723]|Heterozygous|Homozygous mutation of this gene results in embryonic lethality during early gestation. Conditional inactivation in the central nervous system leads to neurodegeneration.|A|G|23|38.0|Non-synonymous|Unprocessed|APF-G1
1789250|IGL00839|11|76233278|H->L||0.01|Benign|0.49|tolerated|MGI:1914451|Glod4|glyoxalase domain containing 4 [Source:MGI Symbol;Acc:MGI:1914451]|Heterozygous||T|A|21|39.0|Non-synonymous|Unprocessed|APF-G1
1789251|IGL00839|1|54667435|N->D||0.01|Benign|0.62|tolerated|MGI:3045243|Ankrd44|ankyrin repeat domain 44 [Source:MGI Symbol;Acc:MGI:3045243]|Heterozygous||T|C|20|37.0|Non-synonymous|Unprocessed|APF-G1
1789252|IGL00839|2|9952917|D->E||0.99|Probably damaging|||MGI:2388097|Taf3|TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor [Source:MGI Symbol;Acc:MGI:2388097]|Heterozygous||A|T|20|35.5|Non-synonymous|Unprocessed|APF-G1
1789253|IGL00839|2|76215385|F->S||0.99|Probably damaging||deleterious|MGI:3036251|Pde11a|phosphodiesterase 11A [Source:MGI Symbol;Acc:MGI:3036251]|Heterozygous||A|G|20|39.5|Non-synonymous|Unprocessed|APF-G1
1789254|IGL00839|2|37816982|V->A||0.6|Possibly damaging|0.12|tolerated|MGI:2442794|Dennd1a|DENN/MADD domain containing 1A [Source:MGI Symbol;Acc:MGI:2442794]|Heterozygous||A|G|19|38.0|Non-synonymous|Unprocessed|APF-G1
1789255|IGL00839|8|78333756|T->I||0.71|Possibly damaging|0.06|tolerated|MGI:1920551|Ttc29|tetratricopeptide repeat domain 29 [Source:MGI Symbol;Acc:MGI:1920551]|Heterozygous||C|T|18|38.5|Non-synonymous|Unprocessed|APF-G1
1789256|IGL00839|19|38698562|Y->C||1.0|Probably damaging||deleterious|MGI:1921305|Plce1|phospholipase C, epsilon 1 [Source:MGI Symbol;Acc:MGI:1921305]|Heterozygous|Homozygous mutation of this gene results in a congenital semilunar valvulogenesis defect which causes regurgitation and stenosis, and decreased incidence of induced skin tumors. Another mutant exhibits decreased cardiac contraction and increased hypertrophy in response to chronic stress.|A|G|17|36.0|Non-synonymous|Unprocessed|APF-G1
1789257|IGL00839|11|74437448|Y->N||1.0|Probably damaging|0.01|deleterious|MGI:3028623|Rap1gap2|RAP1 GTPase activating protein 2 [Source:MGI Symbol;Acc:MGI:3028623]|Heterozygous||A|T|16|38.0|Non-synonymous|Unprocessed|APF-G1
1789258|IGL00839|15|55045778|C->Stop|||N/A|||MGI:2443028|Taf2|TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor [Source:MGI Symbol;Acc:MGI:2443028]|Heterozygous||A|T|16|38.5|Non-synonymous|Unprocessed|APF-G1
1789259|IGL00839|10|41731093|E->G||0.96|Probably damaging|0.15|tolerated|MGI:1915511|Cep57l1|centrosomal protein 57-like 1 [Source:MGI Symbol;Acc:MGI:1915511]|Heterozygous||T|C|14|37.5|Non-synonymous|Unprocessed|APF-G1
1789260|IGL00839|2|155045673|F->I|||Benign|0.11|tolerated|MGI:87853|A|nonagouti [Source:MGI Symbol;Acc:MGI:87853]|Heterozygous|Agouti acts in the hair follicles, primarily affecting the relative amount and distribution of yellow pigment (phaeomelanin) and black pigment (eumelanin) in hairs of the coat. Some alleles show lethal effects or are associated with obesity.|T|A|12|39.0|Non-synonymous|Unprocessed|APF-G1
1789261|IGL00839|11|117714185|T->A||0.1|Benign|0.28|tolerated|MGI:2443265|Tnrc6c|trinucleotide repeat containing 6C [Source:MGI Symbol;Acc:MGI:2443265]|Heterozygous||A|G|10|38.0|Non-synonymous|Unprocessed|APF-G1
1789266|IGL00839|10|33471606|Disrupted splicing||||||MGI:1924007|Trdn|triadin [Source:MGI Symbol;Acc:MGI:1924007]|Heterozygous|Mice homozygous for a null allele exhibit a loss of transverse orientation of triads within skeletal muscle cells.|T|C|84|40.0|Splice|Unprocessed|APF-G1
1789267|IGL00839|17|40239256|Disrupted splicing||||||MGI:102552|Crisp3|cysteine-rich secretory protein 3 [Source:MGI Symbol;Acc:MGI:102552]|Heterozygous||T|G|28|38.0|Splice|Unprocessed|APF-G1
1789268|IGL00839|6|4531095|Disrupted splicing||||||MGI:88468|Col1a2|collagen, type I, alpha 2 [Source:MGI Symbol;Acc:MGI:88468]|Heterozygous|Animals homozygous for a mutation in this gene exhibit reduced body size, reduced bone density and cortical bone thickness, fractured and deformed long bones, dorsal kyphosis, and droopy wrists. Older mutants develop an abnormal gait.|C|T|28|38.5|Splice|Unprocessed|APF-G1
1789269|IGL00839|15|102320547|Disrupted splicing||||||MGI:2146156|Espl1|extra spindle poles-like 1 (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:2146156]|Heterozygous|Homozygous null mice display embryonic lethality before somite formation. Conditional null mice display abnormal mitosis during liver regeneration.|T|C|25|38.0|Splice|Unprocessed|APF-G1
1789728|IGL00840|3|40724877|S->P|||Benign|0.18|tolerated|MGI:1920583|Slc25a31|solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 [Source:MGI Symbol;Acc:MGI:1920583]|Heterozygous|Male mice homozygous for a null allele exhibit infertility, arrested meiosis and increased apoptosis of the spermatocytes.|T|C|94|40.0|Non-synonymous|Unprocessed|APF-G1
1789729|IGL00840|4|46161307|W->R||1.0|Probably damaging|0.01|deleterious|MGI:1891840|Ncbp1|nuclear cap binding protein subunit 1 [Source:MGI Symbol;Acc:MGI:1891840]|Heterozygous||T|A|91|39.0|Non-synonymous|Unprocessed|APF-G1
1789730|IGL00840|17|85458123|L->Stop|||N/A|||MGI:1920832|1700106n22rik|RIKEN cDNA 1700106N22 gene [Source:MGI Symbol;Acc:MGI:1920832]|Heterozygous||T|G|63|39.0|Non-synonymous|Unprocessed|APF-G1
1789731|IGL00840|2|142176658|N->I||0.67|Possibly damaging|0.02|deleterious|MGI:1920149|Macrod2|MACRO domain containing 2 [Source:MGI Symbol;Acc:MGI:1920149]|Heterozygous||A|T|60|39.0|Non-synonymous|Unprocessed|APF-G1
1789732|IGL00840|18|63927327|E->G||0.99|Probably damaging||deleterious|MGI:1860197|Wdr7|WD repeat domain 7 [Source:MGI Symbol;Acc:MGI:1860197]|Heterozygous||A|G|58|39.0|Non-synonymous|Unprocessed|APF-G1
1789733|IGL00840|3|116546114|G->S||0.02|Benign|0.14|tolerated|MGI:105386|Dbt|dihydrolipoamide branched chain transacylase E2 [Source:MGI Symbol;Acc:MGI:105386]|Heterozygous|Homozygous mutation of this gene results in postnatal lethality, pallor, respiratory distress, and an increase in branched-chain amino acids in the blood and urine. Homozygotes model Maple Syrup Urine Disease.|G|A|54|39.0|Non-synonymous|Unprocessed|APF-G1
1789734|IGL00840|1|6833594|E->V||1.0|Probably damaging||deleterious|MGI:2446700|St18|suppression of tumorigenicity 18 [Source:MGI Symbol;Acc:MGI:2446700]|Heterozygous||A|T|51|39.0|Non-synonymous|Unprocessed|APF-G1
1789735|IGL00840|15|82404490|T->S|||Benign|0.19|tolerated|MGI:88602|Cyp2d10|cytochrome P450, family 2, subfamily d, polypeptide 10 [Source:MGI Symbol;Acc:MGI:88602]|Heterozygous||T|A|48|37.5|Non-synonymous|Unprocessed|APF-G1
1789736|IGL00840|5|150980787|I->F||0.98|Probably damaging|0.72|tolerated|MGI:1101771|Kl|klotho [Source:MGI Symbol;Acc:MGI:1101771]|Heterozygous|Homozygous mutant mice have a short lifespan and growth retardation  with one allele homeostatic imbalances and soft tissue calcification are also seen. With a second allele abnormal cancellous bone and femur morphology are seen.|A|T|45|38.0|Non-synonymous|Unprocessed|APF-G1
1789737|IGL00840|6|34394106|S->P||1.0|Probably damaging||deleterious|MGI:1915111|Akr1b10|aldo-keto reductase family 1, member B10 (aldose reductase) [Source:MGI Symbol;Acc:MGI:1915111]|Heterozygous||T|C|44|38.0|Non-synonymous|Unprocessed|APF-G1
1789738|IGL00840|1|164179524|M->T||0.07|Benign|0.01|deleterious|MGI:88382|F5|coagulation factor V [Source:MGI Symbol;Acc:MGI:88382]|Heterozygous||T|C|43|40.0|Non-synonymous|Unprocessed|APF-G1
1789739|IGL00840|13|61251578|Y->C||1.0|Probably damaging||deleterious|MGI:1860275|Cts8|cathepsin 8 [Source:MGI Symbol;Acc:MGI:1860275]|Heterozygous||T|C|40|38.0|Non-synonymous|Unprocessed|APF-G1
1789740|IGL00840|7|24723506|L->H||0.96|Probably damaging|0.29|tolerated|MGI:3643098|Gm4763|predicted gene 4763 [Source:MGI Symbol;Acc:MGI:3643098]|Heterozygous||A|T|38|39.0|Non-synonymous|Unprocessed|APF-G1
1789741|IGL00840|8|85957587|S->R||0.45|Possibly damaging|0.12|tolerated|MGI:97578|Phkb|phosphorylase kinase beta [Source:MGI Symbol;Acc:MGI:97578]|Heterozygous||T|A|38|37.5|Non-synonymous|Unprocessed|APF-G1
1789742|IGL00840|4|41379562|T->A|||Benign|0.53|tolerated|MGI:2149543|Ubap1|ubiquitin-associated protein 1 [Source:MGI Symbol;Acc:MGI:2149543]|Heterozygous||A|G|36|38.0|Non-synonymous|Unprocessed|APF-G1
1789743|IGL00840|1|5070015|V->I||||0.36|tolerated|MGI:1929866|Rgs20|regulator of G-protein signaling 20 [Source:MGI Symbol;Acc:MGI:1929866]|Heterozygous||C|T|33|38.0|Non-synonymous|Unprocessed|APF-G1
1789744|IGL00840|13|54720152|W->R||0.01|Benign|0.38|tolerated|MGI:2687323|Cdhr2|cadherin-related family member 2 [Source:MGI Symbol;Acc:MGI:2687323]|Heterozygous||T|C|33|38.0|Non-synonymous|Unprocessed|APF-G1
1789745|IGL00840|15|77961869|N->K||0.05|Benign|0.47|tolerated|MGI:1933181|Eif3d|eukaryotic translation initiation factor 3, subunit D [Source:MGI Symbol;Acc:MGI:1933181]|Heterozygous||A|T|33|38.0|Non-synonymous|Unprocessed|APF-G1
1789746|IGL00840|X|10208709|I->V||0.04|Benign|0.65|tolerated|MGI:1344037|Rpgr|retinitis pigmentosa GTPase regulator [Source:MGI Symbol;Acc:MGI:1344037]|Heterozygous|Homo- and hemizygotes for an X-linked, targeted, null mutation exhibit ectopic placement of cone opsins, reduced levels of rhodopsin in rod cells, and partial degeneration of both cone and rod photoreceptors by 2-6 months of age.|T|C|31|40.0|Non-synonymous|Unprocessed|APF-G1
1789747|IGL00840|15|94282482|Y->C||1.0|Probably damaging||deleterious|MGI:2660628|Adamts20|a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 20 [Source:MGI Symbol;Acc:MGI:2660628]|Heterozygous|Homozygous mutants have a white belt across the back in the midtrunk region and a white belly patch that coalesces to form a white belt.|T|C|29|38.0|Non-synonymous|Unprocessed|APF-G1
1789749|IGL00840|6|34799159|V->A||0.62|Possibly damaging|0.01|deleterious|MGI:1923473|Agbl3|ATP/GTP binding protein-like 3 [Source:MGI Symbol;Acc:MGI:1923473]|Heterozygous||T|C|21|38.0|Non-synonymous|Unprocessed|APF-G1
1789750|IGL00840|17|30790941|V->M||1.0|Probably damaging||deleterious|MGI:107714|Dnahc8|dynein, axonemal, heavy chain 8 [Source:MGI Symbol;Acc:MGI:107714]|Heterozygous||G|A|20|39.0|Non-synonymous|Unprocessed|APF-G1
1789751|IGL00840|1|156434196|V->G||1.0|Probably damaging||deleterious|MGI:104665|Soat1|sterol O-acyltransferase 1 [Source:MGI Symbol;Acc:MGI:104665]|Heterozygous|Mutants producing no protein or a truncated protein show depletion of cholesterol esters in adrenal cortex and peritoneal macrophages. Additionally, null mutants have reduced eye openings due to atrophy of meibomian glands.|A|C|19|37.0|Non-synonymous|Unprocessed|APF-G1
1789752|IGL00840|10|19005126|V->L||1.0|Probably damaging|0.07|tolerated|MGI:1196377|Tnfaip3|tumor necrosis factor, alpha-induced protein 3 [Source:MGI Symbol;Acc:MGI:1196377]|Heterozygous|Homozygous null mice display partial postnatal lethality, runting, and severe inflammation in the liver, kidneys, joints, intestines, and bone marrow.|C|A|19|39.0|Non-synonymous|Unprocessed|APF-G1
1789753|IGL00840|17|78765437|L->P||1.0|Probably damaging||deleterious|MGI:2444098|Heatr5b|HEAT repeat containing 5B [Source:MGI Symbol;Acc:MGI:2444098]|Heterozygous||A|G|17|36.0|Non-synonymous|Unprocessed|APF-G1
1789754|IGL00840|18|5063555|V->A|||Benign|0.82|tolerated|MGI:2147319|Svil|supervillin [Source:MGI Symbol;Acc:MGI:2147319]|Heterozygous||T|C|17|36.0|Non-synonymous|Unprocessed|APF-G1
1789755|IGL00840|16|55844232|I->V||1.0|Probably damaging|0.14|tolerated|MGI:2686598|Fam55c|family with sequence similarity 55, member C [Source:MGI Symbol;Acc:MGI:2686598]|Heterozygous||T|C|16|39.0|Non-synonymous|Unprocessed|APF-G1
1789756|IGL00840|7|98051659|S->G||||0.03|deleterious|MGI:104510|Myo7a|myosin VIIA [Source:MGI Symbol;Acc:MGI:104510]|Heterozygous|Homozygotes for spontaneous and chemically induced mutations exhibit deafness, hyperactivity, head-shaking, and circling, with degeneration of the organ of Corti, spiral ganglion, stria vascularis in the cochlea, and vestibular ganglion in the labyrinth.|T|C|16|40.0|Non-synonymous|Unprocessed|APF-G1
1789757|IGL00840|7|118852798|Y->H||0.03|Benign|0.54|tolerated|MGI:1913606|2310008h09rik|RIKEN cDNA 2310008H09 gene [Source:MGI Symbol;Acc:MGI:1913606]|Heterozygous||A|G|16|37.5|Non-synonymous|Unprocessed|APF-G1
1789758|IGL00840|3|88057983|I->V|||Benign|0.72|tolerated|MGI:2180167|Apoa1bp|apolipoprotein A-I binding protein [Source:MGI Symbol;Acc:MGI:2180167]|Heterozygous||T|C|15|39.0|Non-synonymous|Unprocessed|APF-G1
1789759|IGL00840|4|141768003|G->V||1.0|Probably damaging|0.07|tolerated|MGI:2442146|Dnajc16|DnaJ (Hsp40) homolog, subfamily C, member 16 [Source:MGI Symbol;Acc:MGI:2442146]|Heterozygous||C|A|15|37.0|Non-synonymous|Unprocessed|APF-G1
1789760|IGL00840|1|130813214|V->M|||Benign|0.21|tolerated|MGI:1927803|Fcamr|Fc receptor, IgA, IgM, high affinity [Source:MGI Symbol;Acc:MGI:1927803]|Heterozygous|Homozygous null mice have enhanced germinal center formation, affinity maturation and memory induction of IgG3 producing B cells after immunization with T cell-independent antigens.|G|A|13|35.0|Non-synonymous|Unprocessed|APF-G1
1789761|IGL00840|10|52144873|T->P||0.15|Benign|0.06|tolerated|MGI:97999|Ros1|Ros1 proto-oncogene [Source:MGI Symbol;Acc:MGI:97999]|Heterozygous|Homozygotes for targeted null mutations exhibit male infertility due to impaired sperm maturation in the epididymis. Mutant sperm are capable of fertilization in vitro but not in vivo.|T|G|11|39.0|Non-synonymous|Unprocessed|APF-G1
1789763|IGL00840|17|88753736|Disrupted splicing||||||MGI:96783|Lhcgr|luteinizing hormone/choriogonadotropin receptor [Source:MGI Symbol;Acc:MGI:96783]|Heterozygous|Homozygous null mutants are infertile and have abnormal hormone levels. Males have undescended testes, immature external and accessory sex organs and blocked spermatogenesis. Females have small ovaries and uteri, immature follicles and do not cycle.|T|C|18|37.0|Splice|Unprocessed|APF-G1
1791242|IGL00843|1|164211791|R->Q||0.05|Benign|0.7|tolerated|MGI:88382|F5|coagulation factor V [Source:MGI Symbol;Acc:MGI:88382]|Heterozygous||G|A|114|39.0|Non-synonymous|Unprocessed|APF-G1
1791243|IGL00843|11|51995375|D->E|||Benign|0.02|deleterious|MGI:102944|Ube2b|ubiquitin-conjugating enzyme E2B, RAD6 homology (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:102944]|Heterozygous|Homozygous null mutants exhibit male sterility with failure at the stage of postmeiotic condensation of chromatin in spermatids. However, in 10-20% of males there is a nearly complete absence of all germ cell types.|A|T|73|40.0|Non-synonymous|Unprocessed|APF-G1
1791244|IGL00843|3|109112860|T->S||0.2|Benign|0.05|tolerated|MGI:1921936|4930443g12rik|RIKEN cDNA 4930443G12 gene [Source:MGI Symbol;Acc:MGI:1921936]|Heterozygous||A|T|45|38.0|Non-synonymous|Unprocessed|APF-G1
1791245|IGL00843|4|144195172|L->F||1.0|Probably damaging|0.01|deleterious|MGI:2684035|Oog2|oogenesin 2 [Source:MGI Symbol;Acc:MGI:2684035]|Heterozygous||G|T|38|39.0|Non-synonymous|Unprocessed|APF-G1
1791246|IGL00843|19|10853263|M->K||0.27|Benign|0.44|tolerated|MGI:1929691|Slc15a3|solute carrier family 15, member 3 [Source:MGI Symbol;Acc:MGI:1929691]|Heterozygous||T|A|35|36.0|Non-synonymous|Unprocessed|APF-G1
1791247|IGL00843|10|94847549|H->R||0.16|Benign|0.64|tolerated|MGI:1890127|Plxnc1|plexin C1 [Source:MGI Symbol;Acc:MGI:1890127]|Heterozygous|Mice homozygous for a knock-out allele exhibit abnormal neuron morphology and migration.|T|C|33|40.0|Non-synonymous|Unprocessed|APF-G1
1791248|IGL00843|4|46396240|M->T|||Benign|1.0|tolerated|MGI:2136910|Hemgn|hemogen [Source:MGI Symbol;Acc:MGI:2136910]|Heterozygous||A|G|29|37.0|Non-synonymous|Unprocessed|APF-G1
1791250|IGL00843|14|63495764|T->A||1.0|Probably damaging||deleterious|MGI:1926231|Tdh|L-threonine dehydrogenase [Source:MGI Symbol;Acc:MGI:1926231]|Heterozygous||T|C|23|39.0|Non-synonymous|Unprocessed|APF-G1
1791251|IGL00843|15|91757058|V->A||0.15|Benign|0.04|deleterious|MGI:1913975|Lrrk2|leucine-rich repeat kinase 2 [Source:MGI Symbol;Acc:MGI:1913975]|Heterozygous|Mice homozygous for a knock-in allele exhibit impaired response to dopamine, amphetamine, and quinpirole.  Mice homozygous for one knock-out allele exhibit increased neurite growth. Mice homozygous for different knock-out alleles exhibit alopecia due to excessive grooming or kdiney atrophy.|T|C|19|39.0|Non-synonymous|Unprocessed|APF-G1
1791252|IGL00843|16|21762629|S->P||0.04|Benign|0.27|tolerated|MGI:1277964|Ehhadh|enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase [Source:MGI Symbol;Acc:MGI:1277964]|Heterozygous|Mice homozygous for disruption of this gene display a normal phenotype.|A|G|19|37.0|Non-synonymous|Unprocessed|APF-G1
1791253|IGL00843|4|143134314|S->L||0.68|Possibly damaging|0.04|deleterious|MGI:107628|Prdm2|PR domain containing 2, with ZNF domain [Source:MGI Symbol;Acc:MGI:107628]|Heterozygous|Homozygous null mice have shortened life spans, becoming moribund due to increased incidence of tumors. Mice had a broad spectrum of unusual tumors in multiple organs, with a high incidence of diffuse large B cell lymphomas.|G|A|19|37.0|Non-synonymous|Unprocessed|APF-G1
1791254|IGL00843|1|58994409|D->E|||Benign|1.0|tolerated|MGI:2144047|Stradb|STE20-related kinase adaptor beta [Source:MGI Symbol;Acc:MGI:2144047]|Heterozygous||T|A|18|39.0|Non-synonymous|Unprocessed|APF-G1
1791255|IGL00843|9|99698821|F->I||0.31|Benign|0.1|tolerated|MGI:1929209|Cldn18|claudin 18 [Source:MGI Symbol;Acc:MGI:1929209]|Heterozygous||A|T|16|33.5|Non-synonymous|Unprocessed|APF-G1
1791256|IGL00843|17|23857362|L->Q||1.0|Probably damaging||deleterious|MGI:1917064|Prss32|protease, serine, 32 [Source:MGI Symbol;Acc:MGI:1917064]|Heterozygous||T|A|15|39.0|Non-synonymous|Unprocessed|APF-G1
1791257|IGL00843|7|132949893|H->P|||Benign|0.29|tolerated|MGI:106441|Zranb1|zinc finger, RAN-binding domain containing 1 [Source:MGI Symbol;Acc:MGI:106441]|Heterozygous||A|C|15|39.0|Non-synonymous|Unprocessed|APF-G1
1791258|IGL00843|12|72463417|I->T|||Benign|0.24|tolerated|MGI:1925507|Lrrc9|leucine rich repeat containing 9 [Source:MGI Symbol;Acc:MGI:1925507]|Heterozygous||T|C|14|34.5|Non-synonymous|Unprocessed|APF-G1
1791259|IGL00843|13|14247573|E->K||1.0|Probably damaging|0.02|deleterious|MGI:2444115|Hecw1|HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 [Source:MGI Symbol;Acc:MGI:2444115]|Heterozygous||C|T|14|40.0|Non-synonymous|Unprocessed|APF-G1
1791260|IGL00843|11|54691273|V->E||0.01|Benign|0.09|tolerated|MGI:2384761|Rapgef6|Rap guanine nucleotide exchange factor (GEF) 6 [Source:MGI Symbol;Acc:MGI:2384761]|Heterozygous|Mice homozygous for a null allele exhibit an inlarged spleen, increased IgE and IgG levels and altered cytokine production.|T|A|13|38.0|Non-synonymous|Unprocessed|APF-G1
1791261|IGL00843|11|83213431|T->M||1.0|Probably damaging|0.02|deleterious|MGI:1329005|Slfn3|schlafen 3 [Source:MGI Symbol;Acc:MGI:1329005]|Heterozygous|Mice homozygous for a targeted allele exhibit normal immune cell populations.|C|T|13|40.0|Non-synonymous|Unprocessed|APF-G1
1791262|IGL00843|1|150610713|I->T||0.65|Possibly damaging|0.01|deleterious|MGI:2685047|Hmcn1|hemicentin 1 [Source:MGI Symbol;Acc:MGI:2685047]|Heterozygous||A|G|12|39.0|Non-synonymous|Unprocessed|APF-G1
1791263|IGL00843|16|95709793|F->V||0.07|Benign|0.4|tolerated|MGI:95456|Ets2|E26 avian leukemia oncogene 2, 3' domain [Source:MGI Symbol;Acc:MGI:95456]|Heterozygous|Homozygotes for targeted null mutations exhibit defective trophoblast formation and die by embryonic day 8.5, but tetraploid chimeric rescue results in viable and fertile mutants with wavy hair. Mammary tumors induced in carriers are reduced in size.|T|G|11|37.0|Non-synonymous|Unprocessed|APF-G1
1791264|IGL00843|16|20703641|T->A||0.31|Benign|0.13|tolerated|MGI:105061|Clcn2|chloride channel 2 [Source:MGI Symbol;Acc:MGI:105061]|Heterozygous|Mice homozygous for a null allele exhibit abnormal brain morphology, male infertility, and abnormal eye morphology.|T|C|10|40.0|Non-synonymous|Unprocessed|APF-G1
1791267|IGL00843|16|22929629|Disrupted splicing||||||MGI:1890221|Fetub|fetuin beta [Source:MGI Symbol;Acc:MGI:1890221]|Heterozygous||A|G|31|38.0|Splice|Unprocessed|APF-G1
1791268|IGL00843|3|88384350|Disrupted splicing||||||MGI:88156|Bglap|bone gamma carboxyglutamate protein [Source:MGI Symbol;Acc:MGI:88156]|Heterozygous|Mice homozygous for a knock-out allele of both Bglap1 and Bglap2 exhibit decreased circulating insulin, impaired glucose tolerance, increased adipose tissue, increased bone density, and decreased male fertility.|A|G|31|37.0|Splice|Unprocessed|APF-G1
1791269|IGL00843|4|4776308|Disrupted splicing||||||MGI:1915720|Impad1|inositol monophosphatase domain containing 1 [Source:MGI Symbol;Acc:MGI:1915720]|Heterozygous|Homozygous null mutants are neonatal lethal with growth retardation.  Mutant embryo shows craniofacial abnormalities and shortened limbs.|T|C|18|40.0|Splice|Unprocessed|APF-G1
1791270|IGL00843|1|38812535|Disrupted splicing||||||MGI:1920209|Lonrf2|LON peptidase N-terminal domain and ring finger 2 [Source:MGI Symbol;Acc:MGI:1920209]|Heterozygous||C|A|15|39.0|Splice|Unprocessed|APF-G1
1791271|IGL00843|6|21851082|Disrupted splicing||||||MGI:1889818|Tspan12|tetraspanin 12 [Source:MGI Symbol;Acc:MGI:1889818]|Heterozygous|Mice homozygous for a knock-out allele exhibit abnormal retinal vasculature with pericapillary occlusions, lack of vertical sprouts, gliosis, fenestration, microanurysms, hemorrhage, and delayed regression of hyaloid capillaries.|T|A|11|37.0|Splice|Unprocessed|APF-G1
1791676|IGL00844|4|136339205|I->M||0.08|Benign|0.08|tolerated|MGI:1891692|Hnrnpr|heterogeneous nuclear ribonucleoprotein R [Source:MGI Symbol;Acc:MGI:1891692]|Heterozygous||A|G|87|39.0|Non-synonymous|Unprocessed|APF-G1
1791677|IGL00844|14|20531686|M->K|||Benign|0.01|deleterious|MGI:107163|Ppp3cb|protein phosphatase 3, catalytic subunit, beta isoform [Source:MGI Symbol;Acc:MGI:107163]|Heterozygous|Homozygous null mice have small hearts and thymi, and reduced body weight. Cardiac function is normal, but mice lack a cardiac hypertrophic response to pressure overload, angiotensin II, or isopreteronol. Thymi are hypoplastic, with abnormal T cell development and reduced numbers of T cells.|A|T|74|39.0|Non-synonymous|Unprocessed|APF-G1
1791678|IGL00844|5|32007307|F->L||0.99|Probably damaging|0.41|tolerated|MGI:1333875|Bre|brain and reproductive organ-expressed protein [Source:MGI Symbol;Acc:MGI:1333875]|Heterozygous||T|A|73|38.0|Non-synonymous|Unprocessed|APF-G1
1791679|IGL00844|12|85843826|V->A||1.0|Probably damaging||deleterious|MGI:2443657|Ttll5|tubulin tyrosine ligase-like family, member 5 [Source:MGI Symbol;Acc:MGI:2443657]|Heterozygous||T|C|56|38.0|Non-synonymous|Unprocessed|APF-G1
1791680|IGL00844|7|17973670|D->E||0.23|Benign|0.04|deleterious|MGI:1914246|Ceacam11|carcinoembryonic antigen-related cell adhesion molecule 11 [Source:MGI Symbol;Acc:MGI:1914246]|Heterozygous||T|G|50|40.0|Non-synonymous|Unprocessed|APF-G1
1791681|IGL00844|2|83923771|N->D|||Benign|0.72|tolerated|MGI:1919111|Zswim2|zinc finger, SWIM domain containing 2 [Source:MGI Symbol;Acc:MGI:1919111]|Heterozygous||T|C|37|38.0|Non-synonymous|Unprocessed|APF-G1
1791682|IGL00844|X|49497754|Q->H||1.0|Probably damaging|0.17|tolerated|MGI:1922654|Arhgap36|Rho GTPase activating protein 36 [Source:MGI Symbol;Acc:MGI:1922654]|Heterozygous||G|T|35|37.0|Non-synonymous|Unprocessed|APF-G1
1791683|IGL00844|17|43617196|M->T|||Benign|0.96|tolerated|MGI:2679727|Tdrd6|tudor domain containing 6 [Source:MGI Symbol;Acc:MGI:2679727]|Heterozygous||A|G|34|39.5|Non-synonymous|Unprocessed|APF-G1
1791684|IGL00844|6|3532177|Q->Stop|||N/A|||MGI:1920538|Ccdc132|coiled-coil domain containing 132 [Source:MGI Symbol;Acc:MGI:1920538]|Heterozygous||C|T|33|40.0|Non-synonymous|Unprocessed|APF-G1
1791685|IGL00844|6|137414239|H->N||0.98|Probably damaging|0.04|deleterious|MGI:1097152|Ptpro|protein tyrosine phosphatase, receptor type, O [Source:MGI Symbol;Acc:MGI:1097152]|Heterozygous|Mice homozygous for one allele display impaired glomerular filtration due to podocyte structural anomalies and a predisposition for hypertension. Mice homozygous for a second allele exhibit susceptibility to pharmacologically induced seizures.|C|A|32|38.5|Non-synonymous|Unprocessed|APF-G1
1791686|IGL00844|17|37009622|Q->K||0.4|Benign|1.0|tolerated|MGI:99204|Zfp57|zinc finger protein 57 [Source:MGI Symbol;Acc:MGI:99204]|Heterozygous|Mice homozygous for a knock-out allele exhibit some postnatal lethality with abnormal imprinting and fetal lethality observed in the homozygous offspring of homozygous females.|C|A|30|39.0|Non-synonymous|Unprocessed|APF-G1
1791687|IGL00844|14|51049756|I->V||0.03|Benign|0.26|tolerated|MGI:3528583|Rnase11|ribonuclease, RNase A family, 11 (non-active) [Source:MGI Symbol;Acc:MGI:3528583]|Heterozygous||T|C|27|38.0|Non-synonymous|Unprocessed|APF-G1
1791688|IGL00844|X|13128446|S->A||0.18|Benign|0.27|tolerated|MGI:894681|Usp9x|ubiquitin specific peptidase 9, X chromosome [Source:MGI Symbol;Acc:MGI:894681]|Heterozygous||T|G|27|38.0|Non-synonymous|Unprocessed|APF-G1
1791689|IGL00844|6|129538635|F->L||0.26|Benign|0.03|deleterious|MGI:1914980|Gabarapl1|gamma-aminobutyric acid (GABA) A receptor-associated protein-like 1 [Source:MGI Symbol;Acc:MGI:1914980]|Heterozygous||T|C|26|39.0|Non-synonymous|Unprocessed|APF-G1
1791690|IGL00844|5|115479626|F->L|||Unknown|||MGI:1922637|Sirt4|sirtuin 4 (silent mating type information regulation 2 homolog) 4 (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1922637]|Heterozygous||A|G|25|40.0|Non-synonymous|Unprocessed|APF-G1
1791691|IGL00844|X|100806593|H->Q||1.0|Probably damaging|0.02|deleterious|MGI:1888986|Dlg3|discs, large homolog 3 (Drosophila) [Source:MGI Symbol;Acc:MGI:1888986]|Heterozygous|Male mice hemizygous for a knock-out allele show alterations in spatial learning, locomotor activation, LTP, and spike-timing-dependent plasticity. A portion of chimeras hemizygous for a gene trapped allele display forebrain deletion, posterior truncation, and failure to initiate embryo turning.|C|A|22|39.0|Non-synonymous|Unprocessed|APF-G1
1791692|IGL00844|2|164317587|K->T||0.62|Possibly damaging||deleterious|MGI:106178|Svs6|seminal vesicle secretory protein 6 [Source:MGI Symbol;Acc:MGI:106178]|Heterozygous||A|C|21|40.0|Non-synonymous|Unprocessed|APF-G1
1791693|IGL00844|7|100929449|V->A|||Benign|0.83|tolerated|MGI:2673002|Arhgef17|Rho guanine nucleotide exchange factor (GEF) 17 [Source:MGI Symbol;Acc:MGI:2673002]|Heterozygous||A|G|21|36.0|Non-synonymous|Unprocessed|APF-G1
1791694|IGL00844|14|32662999|C->Stop|||N/A|||MGI:3588196|3425401b19rik|RIKEN cDNA 3425401B19 gene [Source:MGI Symbol;Acc:MGI:3588196]|Heterozygous||A|T|19|37.0|Non-synonymous|Unprocessed|APF-G1
1791695|IGL00844|14|31147066|D->G|||||deleterious|MGI:2178742|Stab1|stabilin 1 [Source:MGI Symbol;Acc:MGI:2178742]|Heterozygous|Mice homozygous for a knock-out allele exhibit no physical or behavioral abnormalities.|T|C|18|39.0|Non-synonymous|Unprocessed|APF-G1
1791696|IGL00844|6|136560681|V->A|||Benign|0.53|tolerated|MGI:1858965|Atf7ip|activating transcription factor 7 interacting protein [Source:MGI Symbol;Acc:MGI:1858965]|Heterozygous||T|C|18|35.5|Non-synonymous|Unprocessed|APF-G1
1791697|IGL00844|13|81540119|D->G||0.99|Probably damaging|0.08|tolerated|MGI:1274784|Gpr98|G protein-coupled receptor 98 [Source:MGI Symbol;Acc:MGI:1274784]|Heterozygous|Homozygotes for a spontaneous and a targeted mutation exhibit high sensitivity to audiogenic seizures. Targeted mutant mice lack the ankle links that connect growing stereocilia in the developing cochlear hair cells.|T|C|17|39.0|Non-synonymous|Unprocessed|APF-G1
1791698|IGL00844|12|3905622|L->Q||0.88|Possibly damaging||deleterious|MGI:1261827|Dnmt3a|DNA methyltransferase 3A [Source:MGI Symbol;Acc:MGI:1261827]|Heterozygous|Homozygotes for a targeted null mutation become runted and die around four weeks of age.|T|A|14|39.0|Non-synonymous|Unprocessed|APF-G1
1791699|IGL00844|2|91167868|S->A||1.0|Probably damaging|0.01|deleterious|MGI:2444672|Madd|MAP-kinase activating death domain [Source:MGI Symbol;Acc:MGI:2444672]|Heterozygous||A|C|14|40.0|Non-synonymous|Unprocessed|APF-G1
1791700|IGL00844|2|166094492|S->P||0.16|Benign|0.26|tolerated|MGI:1919293|Sulf2|sulfatase 2 [Source:MGI Symbol;Acc:MGI:1919293]|Heterozygous||A|G|12|34.5|Non-synonymous|Unprocessed|APF-G1
1791701|IGL00844|4|46875711|V->A||1.0|Probably damaging||deleterious|MGI:2386030|Gabbr2|gamma-aminobutyric acid (GABA) B receptor, 2 [Source:MGI Symbol;Acc:MGI:2386030]|Heterozygous|Homozygous mutation of this gene results in clonic seizures, hyperactivity, hyperalgesia in response to thermal or mechanical stimuli, increased anxiety, and decreased depression-related behavior.|A|G|11|37.0|Non-synonymous|Unprocessed|APF-G1
1791706|IGL00844|12|78664568|Disrupted splicing||||||MGI:109602|Gphn|gephyrin [Source:MGI Symbol;Acc:MGI:109602]|Heterozygous|Mice homozygous for disruption of this gene die within one day of birth, apparently due to an inability to suckle.  Apnea also develops within 12 hours of birth.|T|C|126|39.0|Splice|Unprocessed|APF-G1
1791707|IGL00844|1|17621540|Disrupted splicing||||||MGI:1934659|Pi15|peptidase inhibitor 15 [Source:MGI Symbol;Acc:MGI:1934659]|Heterozygous||T|C|29|39.0|Splice|Unprocessed|APF-G1
1791708|IGL00844|5|96534853|Disrupted splicing||||||MGI:2385368|Fras1|Fraser syndrome 1 homolog (human) [Source:MGI Symbol;Acc:MGI:2385368]|Heterozygous|Mice homozygous for mutations at this locus display a significant amount of embryonic lethality due to hemorrhaging of embryonic blisters.  Survival is variable on genetic backgrounds.  Kidney development is severely affected and syndactyly is common.|A|G|17|35.0|Splice|Unprocessed|APF-G1
1792189|IGL00845|19|53817949|Y->H||0.96|Probably damaging|0.14|tolerated|MGI:1920963|Rbm20|RNA binding motif protein 20 [Source:MGI Symbol;Acc:MGI:1920963]|Heterozygous||T|C|92|38.0|Non-synonymous|Unprocessed|APF-G1
1792190|IGL00845|17|43626716|D->G||0.02|Benign|0.26|tolerated|MGI:2679727|Tdrd6|tudor domain containing 6 [Source:MGI Symbol;Acc:MGI:2679727]|Heterozygous||T|C|70|37.0|Non-synonymous|Unprocessed|APF-G1
1792192|IGL00845|1|12796967|T->I||1.0|Probably damaging||deleterious|MGI:2138563|Sulf1|sulfatase 1 [Source:MGI Symbol;Acc:MGI:2138563]|Heterozygous|Mice homozygous for a null allele display a slight increase in mortality early in life.|C|T|35|37.0|Non-synonymous|Unprocessed|APF-G1
1792193|IGL00845|6|3532177|Q->Stop|||N/A|||MGI:1920538|Ccdc132|coiled-coil domain containing 132 [Source:MGI Symbol;Acc:MGI:1920538]|Heterozygous||C|T|30|38.5|Non-synonymous|Unprocessed|APF-G1
1792194|IGL00845|X|60127086|D->V|||Benign|0.13|tolerated|MGI:96932|Mcf2|mcf.2 transforming sequence [Source:MGI Symbol;Acc:MGI:96932]|Heterozygous|Homozygous and hemizygous null mice are viable, fertile and behaviorally normal, exhibit normal gonad and brain development and neuronal migration, but show a significant reduction of basal dendritic length in distinct subpopulations of cortical pyramidal neurons.|T|A|30|38.5|Non-synonymous|Unprocessed|APF-G1
1792195|IGL00845|10|84604983|V->A||0.88|Possibly damaging|0.57|tolerated|MGI:2444679|Tcp11l2|t-complex 11 (mouse) like 2 [Source:MGI Symbol;Acc:MGI:2444679]|Heterozygous||T|C|29|39.0|Non-synonymous|Unprocessed|APF-G1
1792196|IGL00845|17|71084429|Y->H||1.0|Probably damaging||deleterious|MGI:1341430|Myom1|myomesin 1 [Source:MGI Symbol;Acc:MGI:1341430]|Heterozygous||T|C|27|37.0|Non-synonymous|Unprocessed|APF-G1
1792197|IGL00845|4|126900613|V->A||0.31|Benign|0.56|tolerated|MGI:1915035|Zmym4|zinc finger, MYM-type 4 [Source:MGI Symbol;Acc:MGI:1915035]|Heterozygous||A|G|24|39.5|Non-synonymous|Unprocessed|APF-G1
1792198|IGL00845|1|150605006|S->F||0.01|Benign|0.07|tolerated|MGI:2685047|Hmcn1|hemicentin 1 [Source:MGI Symbol;Acc:MGI:2685047]|Heterozygous||G|A|19|38.0|Non-synonymous|Unprocessed|APF-G1
1792199|IGL00845|2|125188238|C->S||0.09|Benign||deleterious|MGI:103150|Slc12a1|solute carrier family 12, member 1 [Source:MGI Symbol;Acc:MGI:103150]|Heterozygous|Mice homozygous for disruptions in this gene do not survive to weaning and suffer from various metabolic abnormalities related to kidney function. Mice homozygous for an ENU-induced allele exhibit kidney disease, impaired urinary excretion of metabolism products, polyuria, and kidney alterations.|T|A|19|39.0|Non-synonymous|Unprocessed|APF-G1
1792200|IGL00845|11|60477779|D->G||1.0|Probably damaging|0.01|deleterious|MGI:1261811|Myo15|myosin XV [Source:MGI Symbol;Acc:MGI:1261811]|Heterozygous|Mutations in this gene result in profound deafness and neurological behavior.|A|G|17|34.0|Non-synonymous|Unprocessed|APF-G1
1792201|IGL00845|11|101076952|E->G||0.63|Possibly damaging|0.04|deleterious|MGI:1351641|Naglu|alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB) [Source:MGI Symbol;Acc:MGI:1351641]|Heterozygous|Homozygotes for a targeted null mutation exhibit reduced open field activity, massive accumulation of heparan sulfate in kidney and liver, elevated gangliosides in brain, and presence of vacuoles in macrophages, epithelial cells, and neurons.|A|G|15|38.0|Non-synonymous|Unprocessed|APF-G1
1792202|IGL00845|9|58362462|V->I||0.28|Benign|0.6|tolerated|MGI:1921536|Tbc1d21|TBC1 domain family, member 21 [Source:MGI Symbol;Acc:MGI:1921536]|Heterozygous||C|T|14|38.0|Non-synonymous|Unprocessed|APF-G1
1792203|IGL00845|9|22251518|Disrupted splicing||||||MGI:2679006|Zfp599|zinc finger protein 599 [Source:MGI Symbol;Acc:MGI:2679006]|Heterozygous||T|A|105|39.0|Splice|Unprocessed|APF-G1
1792204|IGL00845|X|70462317|Disrupted splicing||||||MGI:2448555|Bc023829|cDNA sequence BC023829 [Source:MGI Symbol;Acc:MGI:2448555]|Heterozygous||A|T|24|40.0|Splice|Unprocessed|APF-G1
1792205|IGL00845|17|30819276|Disrupted splicing||||||MGI:107714|Dnahc8|dynein, axonemal, heavy chain 8 [Source:MGI Symbol;Acc:MGI:107714]|Heterozygous||T|A|18|37.0|Splice|Unprocessed|APF-G1
1792206|IGL00845|5|53058354|Disrupted splicing||||||MGI:1342284|Slc34a2|solute carrier family 34 (sodium phosphate), member 2 [Source:MGI Symbol;Acc:MGI:1342284]|Heterozygous|Homozygous null mice display embryonic lethality, embryonic growth arrest, failure of embryo turning and somitogenesis, impaired placental development and impaired yolk sac vascular remodeling.|T|C|18|36.5|Splice|Unprocessed|APF-G1
1792207|IGL00845|7|120223951|Disrupted splicing||||||MGI:2388708|Abca14|ATP-binding cassette, sub-family A (ABC1), member 14 [Source:MGI Symbol;Acc:MGI:2388708]|Heterozygous||A|G|15|39.0|Splice|Unprocessed|APF-G1
1792693|IGL00846|3|123371363|K->N||1.0|Probably damaging||deleterious|MGI:2442926|Mettl14|methyltransferase like 14 [Source:MGI Symbol;Acc:MGI:2442926]|Heterozygous||T|A|153|39.0|Non-synonymous|Unprocessed|APF-G1
1792694|IGL00846|3|152193481|N->S||1.0|Probably damaging|0.07|tolerated|MGI:1914285|Dnajb4|DnaJ (Hsp40) homolog, subfamily B, member 4 [Source:MGI Symbol;Acc:MGI:1914285]|Heterozygous||T|C|88|39.0|Non-synonymous|Unprocessed|APF-G1
1792695|IGL00846|1|100164223|C->G||1.0|Probably damaging||deleterious|MGI:3664583|Cntnap5b|contactin associated protein-like 5B [Source:MGI Symbol;Acc:MGI:3664583]|Heterozygous||T|G|76|39.0|Non-synonymous|Unprocessed|APF-G1
1792696|IGL00846|15|75891788|Y->F||0.97|Probably damaging|0.25|tolerated|MGI:2442664|Naprt1|nicotinate phosphoribosyltransferase domain containing 1 [Source:MGI Symbol;Acc:MGI:2442664]|Heterozygous||T|A|57|38.0|Non-synonymous|Unprocessed|APF-G1
1792697|IGL00846|1|107155849|N->I||1.0|Probably damaging||deleterious|MGI:2683293|Serpinb3b|serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3B [Source:MGI Symbol;Acc:MGI:2683293]|Heterozygous||T|A|42|39.0|Non-synonymous|Unprocessed|APF-G1
1792698|IGL00846|8|25720558|I->F||0.11|Benign|0.01|deleterious|MGI:1919160|Ppapdc1b|phosphatidic acid phosphatase type 2 domain containing 1B [Source:MGI Symbol;Acc:MGI:1919160]|Heterozygous||A|T|39|35.0|Non-synonymous|Unprocessed|APF-G1
1792699|IGL00846|4|46396171|T->K||0.87|Possibly damaging|0.06|tolerated|MGI:2136910|Hemgn|hemogen [Source:MGI Symbol;Acc:MGI:2136910]|Heterozygous||G|T|38|39.0|Non-synonymous|Unprocessed|APF-G1
1792700|IGL00846|10|86736933|E->G||1.0|Probably damaging||deleterious|MGI:2387653|Bc030307|cDNA sequence BC030307 [Source:MGI Symbol;Acc:MGI:2387653]|Heterozygous||A|G|37|39.0|Non-synonymous|Unprocessed|APF-G1
1792701|IGL00846|7|126499178|T->A||1.0|Probably damaging||deleterious|MGI:2446242|Atxn2l|ataxin 2-like [Source:MGI Symbol;Acc:MGI:2446242]|Heterozygous||T|C|37|35.0|Non-synonymous|Unprocessed|APF-G1
1792702|IGL00846|2|150472618|G->D||0.66|Possibly damaging|0.05|tolerated|MGI:3652219|Zfp345|zinc finger protein 345 [Source:MGI Symbol;Acc:MGI:3652219]|Heterozygous||C|T|36|39.0|Non-synonymous|Unprocessed|APF-G1
1792703|IGL00846|13|42167616|L->Stop|||N/A|||MGI:96100|Hivep1|human immunodeficiency virus type I enhancer binding protein 1 [Source:MGI Symbol;Acc:MGI:96100]|Heterozygous||T|A|33|39.0|Non-synonymous|Unprocessed|APF-G1
1792704|IGL00846|16|77062405|S->G||0.96|Probably damaging||deleterious|MGI:1353655|Usp25|ubiquitin specific peptidase 25 [Source:MGI Symbol;Acc:MGI:1353655]|Heterozygous||A|G|33|39.0|Non-synonymous|Unprocessed|APF-G1
1792705|IGL00846|6|47193038|L->P||0.32|Benign|0.01|deleterious|MGI:1914047|Cntnap2|contactin associated protein-like 2 [Source:MGI Symbol;Acc:MGI:1914047]|Heterozygous|Inactivation of this gene results in molecular abnormalities within the central nervous system, but homozygous mutant mice show no overt phenotype.|T|C|28|37.0|Non-synonymous|Unprocessed|APF-G1
1792706|IGL00846|5|75640811|N->I||1.0|Probably damaging|0.02|deleterious|MGI:96677|Kit|kit oncogene [Source:MGI Symbol;Acc:MGI:96677]|Heterozygous|Mutations at this locus affect migration of embryonic stem cell populations, resulting in mild to severe impairments in hemopoiesis, and pigmentation. Some alleles are homozygous lethal, sterile, or result in the formation of gastrointestinal tumors.|A|T|26|39.0|Non-synonymous|Unprocessed|APF-G1
1792707|IGL00846|2|105166957|R->L||1.0|Probably damaging||deleterious|MGI:98968|Wt1|Wilms tumor 1 homolog [Source:MGI Symbol;Acc:MGI:98968]|Heterozygous|Homozygous mutants fail to develop normal kidneys or gonads, and on some genetic backgrounds, a spleen. Mutants have abnormalities of the heart, mesothelium and lungs and die between embryonic day 13.5 and birth.|G|T|21|39.0|Non-synonymous|Unprocessed|APF-G1
1792708|IGL00846|17|36871692|L->H||1.0|Probably damaging||deleterious|MGI:1338757|Trim10|tripartite motif-containing 10 [Source:MGI Symbol;Acc:MGI:1338757]|Heterozygous||T|A|20|37.0|Non-synonymous|Unprocessed|APF-G1
1792709|IGL00846|2|178481624|Y->F||0.71|Possibly damaging|0.49|tolerated|MGI:2685856|Cdh26|cadherin-like 26 [Source:MGI Symbol;Acc:MGI:2685856]|Heterozygous||A|T|20|39.0|Non-synonymous|Unprocessed|APF-G1
1792710|IGL00846|13|63340456|T->S||0.97|Probably damaging|0.19|tolerated|MGI:95480|Fancc|Fanconi anemia, complementation group C [Source:MGI Symbol;Acc:MGI:95480]|Heterozygous|Homozygous null mutants are grossly normal, but chromosome aberrations and sensitivity to DNA crosslinkers are seen. Both sexes have fewer germ cell numbers and impaired fertility. Marrow progenitors show decrease in colony forming ability.|T|A|19|33.0|Non-synonymous|Unprocessed|APF-G1
1792711|IGL00846|3|20025792|W->R||0.91|Possibly damaging|0.66|tolerated|MGI:2153839|Hps3|Hermansky-Pudlak syndrome 3 homolog (human) [Source:MGI Symbol;Acc:MGI:2153839]|Heterozygous|Homozygotes for spontaneous null mutations exhibit hypopigmentation and prolonged bleeding associated with a platelet defect.|A|G|19|39.0|Non-synonymous|Unprocessed|APF-G1
1792712|IGL00846|5|114433317|M->K|||Benign|0.18|tolerated|MGI:1924947|Mmab|methylmalonic aciduria (cobalamin deficiency) type B homolog (human) [Source:MGI Symbol;Acc:MGI:1924947]|Heterozygous||A|T|17|39.0|Non-synonymous|Unprocessed|APF-G1
1792713|IGL00846|11|106328118|V->D||0.4|Benign|0.21|tolerated|MGI:98250|Scn4a|sodium channel, voltage-gated, type IV, alpha [Source:MGI Symbol;Acc:MGI:98250]|Heterozygous|Mice heterozygous or homozygous for a knock-in allele develop myotonia, increased myofiber damage, K+-sensitive paralysis and susceptibility to delayed weakness during recovery from fatigue. Homozygotes show perinatal lethality, low survival rate, unusual hind-limb clasping and reduced body weight.|A|T|16|35.0|Non-synonymous|Unprocessed|APF-G1
1792714|IGL00846|3|101860820|Q->L|||Benign|0.02|deleterious|MGI:3607704|Slc22a15|solute carrier family 22 (organic anion/cation transporter), member 15 [Source:MGI Symbol;Acc:MGI:3607704]|Heterozygous||T|A|16|39.0|Non-synonymous|Unprocessed|APF-G1
1792715|IGL00846|6|83120041|F->S||1.0|Probably damaging||deleterious|MGI:104710|Wbp1|WW domain binding protein 1 [Source:MGI Symbol;Acc:MGI:104710]|Heterozygous||A|G|13|38.0|Non-synonymous|Unprocessed|APF-G1
1792716|IGL00846|5|136326796|I->T||0.18|Benign||deleterious|MGI:88568|Cux1|cut-like homeobox 1 [Source:MGI Symbol;Acc:MGI:88568]|Heterozygous|Homozygotes for a targeted null mutation exhibit delayed lung development and neonatal mortality. Survivors show growth retardation and hair defects. Homozygotes for a partially deleted protein have curly hair, and females tend to lose their litters.|A|G|12|36.5|Non-synonymous|Unprocessed|APF-G1
1792717|IGL00846|6|97173316|Y->N||0.39|Benign|0.31|tolerated|MGI:2684999|Tmf1|TATA element modulatory factor 1 [Source:MGI Symbol;Acc:MGI:2684999]|Heterozygous||A|T|10|35.0|Non-synonymous|Unprocessed|APF-G1
1792720|IGL00846|10|100540333|Disrupted splicing||||||MGI:2384917|Cep290|centrosomal protein 290 [Source:MGI Symbol;Acc:MGI:2384917]|Heterozygous|Mice homozygous for a spontaneous in-frame deletion display mislocalization of ciliary and phototransduction proteins resulting in early-onset retinal degeneration.|T|A|111|40.0|Splice|Unprocessed|APF-G1
1792721|IGL00846|13|9720772|Disrupted splicing||||||MGI:1913755|Zmynd11|zinc finger, MYND domain containing 11 [Source:MGI Symbol;Acc:MGI:1913755]|Heterozygous||C|A|70|40.0|Splice|Unprocessed|APF-G1
1792722|IGL00846|5|74587065|Disrupted splicing||||||MGI:1914149|Fip1l1|FIP1 like 1 (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1914149]|Heterozygous||A|G|39|40.0|Splice|Unprocessed|APF-G1
1792723|IGL00846|2|84622010|Disrupted splicing||||||MGI:105100|Ctnnd1|catenin (cadherin associated protein), delta 1 [Source:MGI Symbol;Acc:MGI:105100]|Heterozygous|Mice homozygous for disruptions of this gene die shortly after birth and have morphological abnormalities of the salivary glands and lacrimal gland.|C|T|33|40.0|Splice|Unprocessed|APF-G1
1792724|IGL00846|2|69185555|Disrupted splicing||||||MGI:3606242|Nostrin|nitric oxide synthase trafficker [Source:MGI Symbol;Acc:MGI:3606242]|Heterozygous||C|T|29|39.0|Splice|Unprocessed|APF-G1
1792725|IGL00846|6|57754480|Disrupted splicing||||||MGI:2141658|Vopp1|vesicular, overexpressed in cancer, prosurvival protein 1 [Source:MGI Symbol;Acc:MGI:2141658]|Heterozygous||A|G|28|37.0|Splice|Unprocessed|APF-G1
1792726|IGL00846|2|32199097|Disrupted splicing||||||MGI:1923304|Prrc2b|proline-rich coiled-coil 2B [Source:MGI Symbol;Acc:MGI:1923304]|Heterozygous||T|C|26|36.5|Splice|Unprocessed|APF-G1
1792727|IGL00846|17|24499349|Disrupted splicing||||||MGI:2442952|Caskin1|CASK interacting protein 1 [Source:MGI Symbol;Acc:MGI:2442952]|Heterozygous||T|C|22|37.0|Splice|Unprocessed|APF-G1
1792728|IGL00846|2|172429723|Disrupted splicing||||||MGI:2444482|Cass4|Cas scaffolding protein family member 4 [Source:MGI Symbol;Acc:MGI:2444482]|Heterozygous||A|C|22|36.0|Splice|Unprocessed|APF-G1
1792729|IGL00846|1|54492021|Disrupted splicing||||||MGI:2443342|Pgap1|post-GPI attachment to proteins 1 [Source:MGI Symbol;Acc:MGI:2443342]|Heterozygous|Mutations in this gene result in a variety of forebrain, eye, jaw, craniofacial, ear, and vertebra defects that are background sensitive.|G|T|14|38.0|Splice|Unprocessed|APF-G1
1792730|IGL00846|14|34692744|Disrupted splicing||||||MGI:2675859|Wapal|wings apart-like homolog (Drosophila) [Source:MGI Symbol;Acc:MGI:2675859]|Heterozygous||G|T|13|39.0|Splice|Unprocessed|APF-G1
1793191|IGL00847|2|65670734|D->G||1.0|Probably damaging||deleterious|MGI:98248|Scn2a1|sodium channel, voltage-gated, type II, alpha 1 [Source:MGI Symbol;Acc:MGI:98248]|Heterozygous|Homozygotes for a targeted mutation exhibit excess neuronal apoptosis (especially in the brainstem), reduced neuronal sodium channel currents in vitro, and severe hypoxia resulting in neonatal lethality.|A|G|208|38.0|Non-synonymous|Unprocessed|APF-G1
1793192|IGL00847|2|151660715|A->S|||Benign|0.91|tolerated|MGI:3652039|Rad21l|RAD21-like (S. pombe) [Source:MGI Symbol;Acc:MGI:3652039]|Heterozygous||C|A|151|40.0|Non-synonymous|Unprocessed|APF-G1
1793193|IGL00847|11|78180088|Y->N||1.0|Probably damaging||deleterious|MGI:1915572|Tlcd1|TLC domain containing 1 [Source:MGI Symbol;Acc:MGI:1915572]|Heterozygous||T|A|109|40.0|Non-synonymous|Unprocessed|APF-G1
1793194|IGL00847|8|69742992|C->Stop|||N/A|||MGI:3584369|Zfp866|zinc finger protein 866 [Source:MGI Symbol;Acc:MGI:3584369]|Heterozygous||A|T|87|38.0|Non-synonymous|Unprocessed|APF-G1
1793195|IGL00847|9|88420329|R->S||1.0|Probably damaging||deleterious|MGI:2155664|Snx14|sorting nexin 14 [Source:MGI Symbol;Acc:MGI:2155664]|Heterozygous||C|A|77|39.0|Non-synonymous|Unprocessed|APF-G1
1793196|IGL00847|10|45672357|Y->Stop|||N/A|||MGI:2446110|Hace1|HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1 [Source:MGI Symbol;Acc:MGI:2446110]|Heterozygous|Mice homozygous for a null allele exhibit increased spontaneous and induced tumors.|T|A|68|38.5|Non-synonymous|Unprocessed|APF-G1
1793197|IGL00847|4|145085408|I->T||0.15|Benign|0.05|tolerated|MGI:2448530|Vps13d|vacuolar protein sorting 13 D (yeast) [Source:MGI Symbol;Acc:MGI:2448530]|Heterozygous||A|G|66|37.5|Non-synonymous|Unprocessed|APF-G1
1793198|IGL00847|5|129657914|V->A||0.11|Benign|0.03|deleterious|MGI:99156|Zfp11|zinc finger protein 11 [Source:MGI Symbol;Acc:MGI:99156]|Heterozygous||A|G|63|38.0|Non-synonymous|Unprocessed|APF-G1
1793199|IGL00847|19|57152290|E->G||0.01|Benign|0.32|tolerated|MGI:1194500|Ablim1|actin-binding LIM protein 1 [Source:MGI Symbol;Acc:MGI:1194500]|Heterozygous|Mutant mice lacking the retina-specific isoform are healthy, fertile, and show no defects in retinal development or retinofugal projections.|T|C|52|39.0|Non-synonymous|Unprocessed|APF-G1
1793200|IGL00847|7|24714248|T->A||0.18|Benign|0.94|tolerated|MGI:2681843|Bc049730|cDNA sequence BC049730 [Source:MGI Symbol;Acc:MGI:2681843]|Heterozygous||A|G|52|38.0|Non-synonymous|Unprocessed|APF-G1
1793201|IGL00847|1|82717869|L->F||1.0|Probably damaging||deleterious|MGI:104688|Col4a3|collagen, type IV, alpha 3 [Source:MGI Symbol;Acc:MGI:104688]|Heterozygous|Homozygotes for targeted null mutations exhibit renal pathology including reduced glomerular filtration, impaired glomerular integrity, and glomerulonephrosis, resulting in uremia, proteinuria, and high mortality in young adults.  Auditory thresholds are mildly increased across all test frequencies.|C|T|43|37.0|Non-synonymous|Unprocessed|APF-G1
1793202|IGL00847|2|164317587|K->T||0.62|Possibly damaging||deleterious|MGI:106178|Svs6|seminal vesicle secretory protein 6 [Source:MGI Symbol;Acc:MGI:106178]|Heterozygous||A|C|37|39.0|Non-synonymous|Unprocessed|APF-G1
1793203|IGL00847|2|132819674|L->V||0.06|Benign|0.24|tolerated|MGI:1913884|Mcm8|minichromosome maintenance deficient 8 (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1913884]|Heterozygous||T|G|26|40.0|Non-synonymous|Unprocessed|APF-G1
1793204|IGL00847|12|71075718|P->S||||0.01|deleterious|MGI:2444354|Arid4a|AT rich interactive domain 4A (RBP1-like) [Source:MGI Symbol;Acc:MGI:2444354]|Heterozygous|Mice homozygous for a knock-out allelle exhibit altered DNA methylation patterns, disrupted hematopoeisis and a portion develop acute myeloid leukemia.|C|T|24|37.0|Non-synonymous|Unprocessed|APF-G1
1793205|IGL00847|X|134595198|V->L|||Benign|1.0|tolerated|MGI:1347344|Gla|galactosidase, alpha [Source:MGI Symbol;Acc:MGI:1347344]|Heterozygous|Hemizygous male mutant mice exhibit lamellar inclusions within lysosomes in the kidneys and an accumulation of ceramidetrihexoside in the liver and kidneys, making these mutants a model of Fary disease.|C|A|13|37.0|Non-synonymous|Unprocessed|APF-G1
1793206|IGL00847|14|12215265|N->I|||||deleterious|MGI:97814|Ptprg|protein tyrosine phosphatase, receptor type, G [Source:MGI Symbol;Acc:MGI:97814]|Heterozygous||A|T|12|39.5|Non-synonymous|Unprocessed|APF-G1
1793207|IGL00847|2|181232245|D->G||0.66|Possibly damaging|0.05|tolerated|MGI:2385169|Bc006779|cDNA sequence BC006779 [Source:MGI Symbol;Acc:MGI:2385169]|Heterozygous||T|C|11|38.0|Non-synonymous|Unprocessed|APF-G1
1793211|IGL00847|15|31590927|Disrupted splicing||||||MGI:107185|Cct5|chaperonin containing Tcp1, subunit 5 (epsilon) [Source:MGI Symbol;Acc:MGI:107185]|Heterozygous||T|C|90|39.0|Splice|Unprocessed|APF-G1
1793212|IGL00847|10|82741278|Disrupted splicing||1.0|Probably damaging|||MGI:1915183|Hcfc2|host cell factor C2 [Source:MGI Symbol;Acc:MGI:1915183]|Heterozygous||T|A|85|40.0|Splice|Unprocessed|APF-G1
1793213|IGL00847|8|112767619|Disrupted splicing||||||MGI:2183572|Cntnap4|contactin associated protein-like 4 [Source:MGI Symbol;Acc:MGI:2183572]|Heterozygous||C|T|76|39.0|Splice|Unprocessed|APF-G1
1793214|IGL00847|1|107276260|Disrupted splicing||||||MGI:1277952|Serpinb3c|serine (or cysteine) peptidase inhibitor, clade B, member 3C [Source:MGI Symbol;Acc:MGI:1277952]|Heterozygous||A|G|65|39.0|Splice|Unprocessed|APF-G1
1793215|IGL00847|4|102928921|Disrupted splicing||||||MGI:1920344|Sgip1|SH3-domain GRB2-like (endophilin) interacting protein 1 [Source:MGI Symbol;Acc:MGI:1920344]|Heterozygous||A|G|43|38.0|Splice|Unprocessed|APF-G1
1793216|IGL00847|17|57034957|Disrupted splicing||||||MGI:2144215|Slc25a41|solute carrier family 25, member 41 [Source:MGI Symbol;Acc:MGI:2144215]|Heterozygous||G|T|13|40.0|Splice|Unprocessed|APF-G1
1793217|IGL00847|5|112830389|Disrupted splicing||||||MGI:1921626|Myo18b|myosin XVIIIb [Source:MGI Symbol;Acc:MGI:1921626]|Heterozygous|Mice homozygous for a null mutation display embryonic lethality during organogenesis with internal hemorrhage, pericaridal effusion, enlargement of the right atrium, and cardiac myofibril abnormalities.|A|G|12|37.0|Splice|Unprocessed|APF-G1
1793729|IGL00848|7|65303194|Q->R|||Benign|0.42|tolerated|MGI:98759|Tjp1|tight junction protein 1 [Source:MGI Symbol;Acc:MGI:98759]|Heterozygous||T|C|183|39.0|Non-synonymous|Unprocessed|APF-G1
1793730|IGL00848|5|145862465|I->N||1.0|Probably damaging||deleterious|MGI:88609|Cyp3a11|cytochrome P450, family 3, subfamily a, polypeptide 11 [Source:MGI Symbol;Acc:MGI:88609]|Heterozygous||A|T|111|39.0|Non-synonymous|Unprocessed|APF-G1
1793731|IGL00848|2|164256101|E->G||0.61|Possibly damaging|||MGI:3583778|Svs3b|seminal vesicle secretory protein 3B [Source:MGI Symbol;Acc:MGI:3583778]|Heterozygous||T|C|103|37.0|Non-synonymous|Unprocessed|APF-G1
1793732|IGL00848|5|21683193|M->K||0.02|Benign|0.31|tolerated|MGI:2140885|Napepld|N-acyl phosphatidylethanolamine phospholipase D [Source:MGI Symbol;Acc:MGI:2140885]|Heterozygous|Mice homozygous for a null mutation are viable and healthy, but have abnormal brain levels of N-acyl ethanolamines and N-acyl phosphatidylethanolamines.|A|T|100|38.0|Non-synonymous|Unprocessed|APF-G1
1793733|IGL00848|10|84680377|D->G||0.97|Probably damaging||deleterious|MGI:1917678|Polr3b|polymerase (RNA) III (DNA directed) polypeptide B [Source:MGI Symbol;Acc:MGI:1917678]|Heterozygous||A|G|96|40.0|Non-synonymous|Unprocessed|APF-G1
1793734|IGL00848|9|4331184|S->R||1.0|Probably damaging|0.07|tolerated|MGI:1916399|Kbtbd3|kelch repeat and BTB (POZ) domain containing 3 [Source:MGI Symbol;Acc:MGI:1916399]|Heterozygous||T|A|83|38.0|Non-synonymous|Unprocessed|APF-G1
1793735|IGL00848|5|50001949|G->R||1.0|Probably damaging||deleterious|MGI:1917943|Gpr125|G protein-coupled receptor 125 [Source:MGI Symbol;Acc:MGI:1917943]|Heterozygous|Homozygous mutant mice are fertile and grossly normal.|C|T|80|37.0|Non-synonymous|Unprocessed|APF-G1
1793736|IGL00848|1|131164436|Q->Stop|||N/A|||MGI:109342|Eif2d|eukaryotic translation initiation factor 2D [Source:MGI Symbol;Acc:MGI:109342]|Heterozygous||C|T|76|35.0|Non-synonymous|Unprocessed|APF-G1
1793737|IGL00848|11|108472060|D->G||0.5|Possibly damaging|0.02|deleterious|MGI:1923673|Ccdc46|coiled-coil domain containing 46 [Source:MGI Symbol;Acc:MGI:1923673]|Heterozygous||A|G|71|38.0|Non-synonymous|Unprocessed|APF-G1
1793738|IGL00848|1|104934256|H->Y||0.06|Benign|1.0|tolerated|MGI:1346069|Cdh20|cadherin 20 [Source:MGI Symbol;Acc:MGI:1346069]|Heterozygous||C|T|68|39.0|Non-synonymous|Unprocessed|APF-G1
1793739|IGL00848|5|99222378|F->L||0.99|Probably damaging|0.01|deleterious|MGI:2443755|Rasgef1b|RasGEF domain family, member 1B [Source:MGI Symbol;Acc:MGI:2443755]|Heterozygous||A|G|68|38.0|Non-synonymous|Unprocessed|APF-G1
1793740|IGL00848|7|131246724|E->G||1.0|Probably damaging||deleterious|MGI:1918645|5430419d17rik|RIKEN cDNA 5430419D17 gene [Source:MGI Symbol;Acc:MGI:1918645]|Heterozygous||A|G|63|39.0|Non-synonymous|Unprocessed|APF-G1
1793741|IGL00848|1|181105125|D->V||1.0|Probably damaging||deleterious|MGI:1914709|Nvl|nuclear VCP-like [Source:MGI Symbol;Acc:MGI:1914709]|Heterozygous||T|A|61|37.0|Non-synonymous|Unprocessed|APF-G1
1793742|IGL00848|1|106339448|T->M||1.0|Probably damaging|0.05|deleterious|MGI:2138327|Phlpp1|PH domain and leucine rich repeat protein phosphatase 1 [Source:MGI Symbol;Acc:MGI:2138327]|Heterozygous|Mice homozygous for a null mutation display impairment in the ability to stabilize the circadian period after light induced resetting.|C|T|59|39.0|Non-synonymous|Unprocessed|APF-G1
1793743|IGL00848|15|45113228|I->T|||Benign|0.4|tolerated|MGI:1914748|Kcnv1|potassium channel, subfamily V, member 1 [Source:MGI Symbol;Acc:MGI:1914748]|Heterozygous|At weaning, homozygous mutant mice exhibit tetany, tremors and ataxia.|A|G|59|38.0|Non-synonymous|Unprocessed|APF-G1
1793744|IGL00848|15|34508729|T->A||0.02|Benign|0.75|tolerated|MGI:1914974|Pop1|processing of precursor 1, ribonuclease P/MRP family, (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1914974]|Heterozygous||A|G|57|37.0|Non-synonymous|Unprocessed|APF-G1
1793745|IGL00848|3|9565239|S->T||0.03|Benign|0.03|deleterious|MGI:2180715|Zfp704|zinc finger protein 704 [Source:MGI Symbol;Acc:MGI:2180715]|Heterozygous|Mice homozygous for a reporter (null) allele are viable and fertile with no obvious developmental defects.|A|T|55|37.0|Non-synonymous|Unprocessed|APF-G1
1793746|IGL00848|13|55159170|E->G||0.9|Possibly damaging|0.04|deleterious|MGI:95525|Fgfr4|fibroblast growth factor receptor 4 [Source:MGI Symbol;Acc:MGI:95525]|Heterozygous|Homozygotes for a targeted mutation are viable, healthy and overtly normal, except for a 10% weight reduction at weaning. Mice doubly homozygous for disruptions of Fgfr3 and Fgfr4 show novel phenotypes not seen in either single mutant, including dwarfism and defective respiratory alveogenesis.|A|G|51|37.0|Non-synonymous|Unprocessed|APF-G1
1793747|IGL00848|9|78435488|P->L||1.0|Probably damaging|0.02|deleterious|MGI:2442261|E330016a19rik|RIKEN cDNA E330016A19 gene [Source:MGI Symbol;Acc:MGI:2442261]|Heterozygous||G|A|50|38.5|Non-synonymous|Unprocessed|APF-G1
1793748|IGL00848|17|74696393|Q->Stop|||N/A|||MGI:1276108|Birc6|baculoviral IAP repeat-containing 6 [Source:MGI Symbol;Acc:MGI:1276108]|Heterozygous|Homozygous mice exhibit perinatal lethality and exhibit placental defects.|C|T|49|39.0|Non-synonymous|Unprocessed|APF-G1
1793749|IGL00848|4|3871459|N->S||0.48|Possibly damaging|0.03|deleterious|MGI:97052|Mos|Moloney sarcoma oncogene [Source:MGI Symbol;Acc:MGI:97052]|Heterozygous|Mutations that inactivate the gene result in female infertility and an increased susceptibility to tumors. Oocytes progress through meiosis II without arrest and undergo spontaneous parthenogenetic activation. Male mice are fertile and show no spermatogenic defects.|T|C|46|35.0|Non-synonymous|Unprocessed|APF-G1
1793750|IGL00848|13|41012623|E->D||0.03|Benign|0.27|tolerated|MGI:1915333|Pak1ip1|PAK1 interacting protein 1 [Source:MGI Symbol;Acc:MGI:1915333]|Heterozygous||A|T|41|37.0|Non-synonymous|Unprocessed|APF-G1
1793751|IGL00848|1|139831232|T->S||0.16|Benign|0.23|tolerated|MGI:3611575|Cfhr2|complement factor H-related 2 [Source:MGI Symbol;Acc:MGI:3611575]|Heterozygous||T|A|38|38.0|Non-synonymous|Unprocessed|APF-G1
1793752|IGL00848|5|100893144|M->L||0.09|Benign|0.11|tolerated|MGI:3603816|Agpat9|1-acylglycerol-3-phosphate O-acyltransferase 9 [Source:MGI Symbol;Acc:MGI:3603816]|Heterozygous||A|T|37|37.0|Non-synonymous|Unprocessed|APF-G1
1793753|IGL00848|1|82340444|L->P||0.92|Possibly damaging|0.14|tolerated|MGI:1924117|Rhbdd1|rhomboid domain containing 1 [Source:MGI Symbol;Acc:MGI:1924117]|Heterozygous||T|C|36|38.0|Non-synonymous|Unprocessed|APF-G1
1793754|IGL00848|1|172110688|C->S||0.12|Benign|0.01|deleterious|MGI:1334462|Copa|coatomer protein complex subunit alpha [Source:MGI Symbol;Acc:MGI:1334462]|Heterozygous||T|A|35|38.0|Non-synonymous|Unprocessed|APF-G1
1793755|IGL00848|9|14727411|T->P||0.78|Possibly damaging|0.19|tolerated|MGI:3041167|Piwil4|piwi-like homolog 4 (Drosophila) [Source:MGI Symbol;Acc:MGI:3041167]|Heterozygous||T|G|33|39.0|Non-synonymous|Unprocessed|APF-G1
1793756|IGL00848|19|46590157|I->F||0.99|Probably damaging||deleterious|MGI:2137678|Sfxn2|sideroflexin 2 [Source:MGI Symbol;Acc:MGI:2137678]|Heterozygous||A|T|32|38.0|Non-synonymous|Unprocessed|APF-G1
1793757|IGL00848|15|35114622|E->V||0.01|Benign||deleterious|MGI:1928487|Stk3|serine/threonine kinase 3 (Ste20, yeast homolog) [Source:MGI Symbol;Acc:MGI:1928487]|Heterozygous|Mice homozygous for a null allele are viable and fertile with no morphological abnormalities.|T|A|30|39.5|Non-synonymous|Unprocessed|APF-G1
1793758|IGL00848|3|27451509|L->Q||1.0|Probably damaging|0.01|deleterious|MGI:1919257|Fndc3b|fibronectin type III domain containing 3B [Source:MGI Symbol;Acc:MGI:1919257]|Heterozygous|Mice homozygous for a knock-out allele die shortly after birth despite normal energy homeostasis. Mouse embryonic fibroblasts homozygous for a knock-out allele exhibit impaired adipogenesis and enhanced osteogenesis.|A|T|29|38.0|Non-synonymous|Unprocessed|APF-G1
1793759|IGL00848|18|4380717|H->Y||0.03|Benign|1.0|tolerated|MGI:1914690|Mtpap|mitochondrial poly(A) polymerase [Source:MGI Symbol;Acc:MGI:1914690]|Heterozygous||C|T|28|39.0|Non-synonymous|Unprocessed|APF-G1
1793760|IGL00848|3|93322897|K->N|||Unknown|||MGI:3046938|Hrnr|hornerin [Source:MGI Symbol;Acc:MGI:3046938]|Heterozygous||A|T|28|40.0|Non-synonymous|Unprocessed|APF-G1
1793761|IGL00848|2|120512727|N->K|||||deleterious|MGI:1270153|Zfp106|zinc finger protein 106 [Source:MGI Symbol;Acc:MGI:1270153]|Heterozygous||A|T|26|39.0|Non-synonymous|Unprocessed|APF-G1
1793762|IGL00848|1|106376255|R->H||1.0|Probably damaging|0.01|deleterious|MGI:2138327|Phlpp1|PH domain and leucine rich repeat protein phosphatase 1 [Source:MGI Symbol;Acc:MGI:2138327]|Heterozygous|Mice homozygous for a null mutation display impairment in the ability to stabilize the circadian period after light induced resetting.|G|A|25|37.0|Non-synonymous|Unprocessed|APF-G1
1793763|IGL00848|1|131757528|S->F||0.45|Possibly damaging|0.01|deleterious|MGI:2444594|Slc26a9|solute carrier family 26, member 9 [Source:MGI Symbol;Acc:MGI:2444594]|Heterozygous|Mice homozygous for a null allele exhibit reduced gastric secretory membranes and loss of gastric acid secretion.|C|T|25|37.0|Non-synonymous|Unprocessed|APF-G1
1793764|IGL00848|19|17119118|K->I||1.0|Probably damaging||deleterious|MGI:1925004|Prune2|prune homolog 2 (Drosophila) [Source:MGI Symbol;Acc:MGI:1925004]|Heterozygous||A|T|24|37.5|Non-synonymous|Unprocessed|APF-G1
1793765|IGL00848|14|51987427|V->M||1.0|Probably damaging|0.01|deleterious|MGI:2685515|Arhgef40|Rho guanine nucleotide exchange factor (GEF) 40 [Source:MGI Symbol;Acc:MGI:2685515]|Heterozygous||G|A|23|37.0|Non-synonymous|Unprocessed|APF-G1
1793766|IGL00848|7|45123501|R->Q||0.06|Benign|0.16|tolerated|MGI:1351329|Rps11|ribosomal protein S11 [Source:MGI Symbol;Acc:MGI:1351329]|Heterozygous||C|T|23|39.0|Non-synonymous|Unprocessed|APF-G1
1793767|IGL00848|9|75289181|E->G||0.6|Possibly damaging|0.06|tolerated|MGI:2442485|Myo5c|myosin VC [Source:MGI Symbol;Acc:MGI:2442485]|Heterozygous||A|G|23|38.0|Non-synonymous|Unprocessed|APF-G1
1793768|IGL00848|15|5235108|I->V||0.02|Benign|0.68|tolerated|MGI:104311|Ptger4|prostaglandin E receptor 4 (subtype EP4) [Source:MGI Symbol;Acc:MGI:104311]|Heterozygous|Most homozygous targeted null mutants die shortly after birth due to failed closure of the ductus arteriosis. Survivors show decreased migration of Langerhans cells to lymph nodes, contact hypersensitivity and decreased incidence of induced arthritis.|T|C|18|38.0|Non-synonymous|Unprocessed|APF-G1
1793769|IGL00848|7|126371242|E->G||0.3|Benign|0.13|tolerated|MGI:1920908|Spns1|spinster homolog 1 (Drosophila) [Source:MGI Symbol;Acc:MGI:1920908]|Heterozygous|Homozygous mutation results in lethality before weaning.|T|C|17|37.0|Non-synonymous|Unprocessed|APF-G1
1793770|IGL00848|11|61302233|V->M||0.61|Possibly damaging|0.1|tolerated|MGI:3588190|Slc47a2|solute carrier family 47, member 2 [Source:MGI Symbol;Acc:MGI:3588190]|Heterozygous||C|T|16|37.5|Non-synonymous|Unprocessed|APF-G1
1793771|IGL00848|11|120444270|S->P|||Benign|0.34|tolerated|MGI:2384781|Tspan10|tetraspanin 10 [Source:MGI Symbol;Acc:MGI:2384781]|Heterozygous||T|C|13|39.0|Non-synonymous|Unprocessed|APF-G1
1793772|IGL00848|5|144176398|E->G|||Benign|0.19|tolerated|MGI:3036247|Lmtk2|lemur tyrosine kinase 2 [Source:MGI Symbol;Acc:MGI:3036247]|Heterozygous||A|G|13|37.0|Non-synonymous|Unprocessed|APF-G1
1793774|IGL00848|1|32472752|A->V|||Benign|0.13|tolerated|MGI:2159649|Khdrbs2|KH domain containing, RNA binding, signal transduction associated 2 [Source:MGI Symbol;Acc:MGI:2159649]|Heterozygous||C|T|11|38.0|Non-synonymous|Unprocessed|APF-G1
1793775|IGL00848|5|112871485|T->I||1.0|Probably damaging||deleterious|MGI:1921626|Myo18b|myosin XVIIIb [Source:MGI Symbol;Acc:MGI:1921626]|Heterozygous|Mice homozygous for a null mutation display embryonic lethality during organogenesis with internal hemorrhage, pericaridal effusion, enlargement of the right atrium, and cardiac myofibril abnormalities.|G|A|10|39.5|Non-synonymous|Unprocessed|APF-G1
1793776|IGL00848|7|140942404|G->D||1.0|Probably damaging||deleterious|MGI:2444047|Athl1|ATH1, acid trehalase-like 1 (yeast) [Source:MGI Symbol;Acc:MGI:2444047]|Heterozygous||G|A|10|38.0|Non-synonymous|Unprocessed|APF-G1
1793781|IGL00848|3|96056973|Disrupted splicing||||||MGI:891965|Vps45|vacuolar protein sorting 45 (yeast) [Source:MGI Symbol;Acc:MGI:891965]|Heterozygous||G|T|96|38.0|Splice|Unprocessed|APF-G1
1793782|IGL00848|15|103298749|Disrupted splicing||||||MGI:1929063|Copz1|coatomer protein complex, subunit zeta 1 [Source:MGI Symbol;Acc:MGI:1929063]|Heterozygous||T|A|42|37.0|Splice|Unprocessed|APF-G1
1793783|IGL00848|10|82662165|Disrupted splicing||||||MGI:1922032|Glt8d2|glycosyltransferase 8 domain containing 2 [Source:MGI Symbol;Acc:MGI:1922032]|Heterozygous||C|T|38|38.0|Splice|Unprocessed|APF-G1
1793784|IGL00848|19|44192279|Disrupted splicing||||||MGI:1352448|Pkd2l1|polycystic kidney disease 2-like 1 [Source:MGI Symbol;Acc:MGI:1352448]|Heterozygous|Mice homozygous for a knock-out allele exhibit decreased chorda tympani nerve response to sour tastants.|A|T|32|35.5|Splice|Unprocessed|APF-G1
1793785|IGL00848|11|85051181|Disrupted splicing||||||MGI:2144475|Usp32|ubiquitin specific peptidase 32 [Source:MGI Symbol;Acc:MGI:2144475]|Heterozygous||T|C|29|40.0|Splice|Unprocessed|APF-G1
1793786|IGL00848|10|43967818|Disrupted splicing||||||MGI:109544|Aim1|absent in melanoma 1 [Source:MGI Symbol;Acc:MGI:109544]|Heterozygous||A|C|24|38.0|Splice|Unprocessed|APF-G1
1794272|IGL00849|16|60425111|I->L||||0.02|deleterious|MGI:108034|Epha6|Eph receptor A6 [Source:MGI Symbol;Acc:MGI:108034]|Heterozygous|Mice homozygous for a knock-out allele display discrete learning and memory deficits.|T|G|93|39.0|Non-synonymous|Unprocessed|APF-G1
1794273|IGL00849|13|96420733|E->D||1.0|Probably damaging|0.01|deleterious|MGI:2444730|Ankdd1b|ankyrin repeat and death domain containing 1B [Source:MGI Symbol;Acc:MGI:2444730]|Heterozygous||C|A|67|38.0|Non-synonymous|Unprocessed|APF-G1
1794274|IGL00849|11|70706127|L->F||1.0|Probably damaging||deleterious|MGI:1098260|Kif1c|kinesin family member 1C [Source:MGI Symbol;Acc:MGI:1098260]|Heterozygous|Mice homozygous for a reporter allele are viable, fertile and overtly normal and display normal motor-dependent retrograde Golgi apparatus-to-endoplasmic reticulum transport.|G|T|66|39.0|Non-synonymous|Unprocessed|APF-G1
1794275|IGL00849|11|120580239|D->Y||1.0|Probably damaging||deleterious|MGI:2178103|Arhgdia|Rho GDP dissociation inhibitor (GDI) alpha [Source:MGI Symbol;Acc:MGI:2178103]|Heterozygous||C|A|65|38.0|Non-synonymous|Unprocessed|APF-G1
1794276|IGL00849|6|136765614|K->R|||Benign|0.42|tolerated|MGI:106903|Gucy2c|guanylate cyclase 2c [Source:MGI Symbol;Acc:MGI:106903]|Heterozygous|Homozygous null mice are viable and have an increased resistance to heat-stable enterotoxins.|T|C|64|38.0|Non-synonymous|Unprocessed|APF-G1
1794277|IGL00849|17|32775899|Y->H|||Benign|0.15|tolerated|MGI:1921793|Zfp871|zinc finger protein 871 [Source:MGI Symbol;Acc:MGI:1921793]|Heterozygous||A|G|59|38.0|Non-synonymous|Unprocessed|APF-G1
1794278|IGL00849|9|78435488|P->L||1.0|Probably damaging|0.02|deleterious|MGI:2442261|E330016a19rik|RIKEN cDNA E330016A19 gene [Source:MGI Symbol;Acc:MGI:2442261]|Heterozygous||G|A|45|39.0|Non-synonymous|Unprocessed|APF-G1
1794279|IGL00849|4|28870662|E->G||0.82|Possibly damaging|0.03|deleterious|MGI:95276|Epha7|Eph receptor A7 [Source:MGI Symbol;Acc:MGI:95276]|Heterozygous|Some homozygous mutants display anencephaly. Mutants also exhibit increased proliferation of neural progenitor cells in the lateral ventricle wall of the adult brain.|A|G|44|39.0|Non-synonymous|Unprocessed|APF-G1
1794280|IGL00849|13|11585478|L->I||0.99|Probably damaging|0.01|deleterious|MGI:99685|Ryr2|ryanodine receptor 2, cardiac [Source:MGI Symbol;Acc:MGI:99685]|Heterozygous|Mice homozygous for a null mutation display embryonic lethality during organogenesis and abnormal cardiomyocyte morphology. Mice homozygous for a phosphorylation defective allele display decreased susceptibility to myocardial infarction-induced heart failure.|G|T|34|38.0|Non-synonymous|Unprocessed|APF-G1
1794281|IGL00849|15|66636832|P->T||0.62|Possibly damaging|0.22|tolerated|MGI:2444412|Phf20l1|PHD finger protein 20-like 1 [Source:MGI Symbol;Acc:MGI:2444412]|Heterozygous||C|A|34|39.0|Non-synonymous|Unprocessed|APF-G1
1794282|IGL00849|8|105842168|D->Y||0.91|Possibly damaging||deleterious|MGI:1919486|Tsnaxip1|translin-associated factor X (Tsnax) interacting protein 1 [Source:MGI Symbol;Acc:MGI:1919486]|Heterozygous||G|T|31|38.0|Non-synonymous|Unprocessed|APF-G1
1794283|IGL00849|2|155421688|Q->H||0.83|Possibly damaging|0.31|tolerated|MGI:1929915|Ncoa6|nuclear receptor coactivator 6 [Source:MGI Symbol;Acc:MGI:1929915]|Heterozygous|Homozygotes for targeted null mutations exhibit retarded embryonic growth and defects of the placenta, heart, liver, and nervous system. Mutants die around midgestation.|T|A|30|35.0|Non-synonymous|Unprocessed|APF-G1
1794284|IGL00849|6|97308060|I->F||1.0|Probably damaging|0.01|deleterious|MGI:2141794|Frmd4b|FERM domain containing 4B [Source:MGI Symbol;Acc:MGI:2141794]|Heterozygous||T|A|29|38.0|Non-synonymous|Unprocessed|APF-G1
1794285|IGL00849|1|165152040|T->S||0.42|Benign|0.03|deleterious|MGI:1891158|Tbx19|T-box 19 [Source:MGI Symbol;Acc:MGI:1891158]|Heterozygous|The phenotype of homozygous null mice is similar to that of patients with early onset pituitary ACTH deficiency. They are characterized by fasting-induced hypoglycemia due to an impaired pituitary-adrenal axis.|T|A|24|37.0|Non-synonymous|Unprocessed|APF-G1
1794286|IGL00849|13|20582323|K->Stop|||N/A|||MGI:2153044|Elmo1|engulfment and cell motility 1, ced-12 homolog (C. elegans) [Source:MGI Symbol;Acc:MGI:2153044]|Heterozygous|Mice homozygous for a knock-out allele exhibit impaired Sertoli cell phagocytosis of apoptotic male germ cells.|A|T|22|40.0|Non-synonymous|Unprocessed|APF-G1
1794287|IGL00849|13|55482189|R->S||1.0|Probably damaging|0.16|tolerated|MGI:1931838|Dbn1|drebrin 1 [Source:MGI Symbol;Acc:MGI:1931838]|Heterozygous|Homozygous null mice have defects in cued conditioning behavior.|G|T|22|37.0|Non-synonymous|Unprocessed|APF-G1
1794288|IGL00849|10|76292318|I->N||0.9|Possibly damaging||deleterious|MGI:2385920|Dip2a|DIP2 disco-interacting protein 2 homolog A (Drosophila) [Source:MGI Symbol;Acc:MGI:2385920]|Heterozygous||A|T|16|39.0|Non-synonymous|Unprocessed|APF-G1
1794289|IGL00849|16|73973777|T->A||0.02|Benign|0.06|tolerated|MGI:1890110|Robo2|roundabout homolog 2 (Drosophila) [Source:MGI Symbol;Acc:MGI:1890110]|Heterozygous|Homozygous mutants display postnatal lethality, abnormal ureteric bud development, multiple fused kidneys, multiple ureters, and abnormal commissural axon growth.|T|C|16|39.0|Non-synonymous|Unprocessed|APF-G1
1794290|IGL00849|5|33408848|G->V|||Benign|0.3|tolerated|MGI:1918351|4933407h18rik|RIKEN cDNA 4933407H18 gene [Source:MGI Symbol;Acc:MGI:1918351]|Heterozygous||G|T|15|36.0|Non-synonymous|Unprocessed|APF-G1
1794291|IGL00849|7|4920806|L->I||0.99|Probably damaging|0.01|deleterious|MGI:2665174|Zfp628|zinc finger protein 628 [Source:MGI Symbol;Acc:MGI:2665174]|Heterozygous||C|A|10|39.5|Non-synonymous|Unprocessed|APF-G1
1794296|IGL00849|16|57149810|Disrupted splicing||||||MGI:106295|Tomm70a|translocase of outer mitochondrial membrane 70 homolog A (yeast) [Source:MGI Symbol;Acc:MGI:106295]|Heterozygous||T|C|28|37.0|Splice|Unprocessed|APF-G1
1794793|IGL00850|10|58258248|D->E|||Benign|1.0|tolerated|MGI:1917547|Gcc2|GRIP and coiled-coil domain containing 2 [Source:MGI Symbol;Acc:MGI:1917547]|Heterozygous||C|A|310|40.0|Non-synonymous|Unprocessed|APF-G1
1794794|IGL00850|9|15322852|L->S||0.98|Probably damaging||deleterious|MGI:2442521|5830418k08rik|RIKEN cDNA 5830418K08 gene [Source:MGI Symbol;Acc:MGI:2442521]|Heterozygous||A|G|155|38.0|Non-synonymous|Unprocessed|APF-G1
1794795|IGL00850|8|13767575|Y->Stop|||N/A|||MGI:1917207|Cdc16|CDC16 cell division cycle 16 homolog (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1917207]|Heterozygous||T|G|134|40.0|Non-synonymous|Unprocessed|APF-G1
1794796|IGL00850|5|137464113|T->A|||Unknown|0.04|deleterious|MGI:106656|Zan|zonadhesin [Source:MGI Symbol;Acc:MGI:106656]|Heterozygous|Sperm from mice homozygous for a knock-out allele exhibit decreased species-specific zona pellucida adhesion without alteration in fertility.|T|C|81|38.0|Non-synonymous|Unprocessed|APF-G1
1794797|IGL00850|7|100034641|T->A||0.9|Possibly damaging|0.03|deleterious|MGI:1916371|Chrdl2|chordin-like 2 [Source:MGI Symbol;Acc:MGI:1916371]|Heterozygous||A|G|70|38.5|Non-synonymous|Unprocessed|APF-G1
1794798|IGL00850|19|44235808|H->R||1.0|Probably damaging||deleterious|MGI:1353437|Scd3|stearoyl-coenzyme A desaturase 3 [Source:MGI Symbol;Acc:MGI:1353437]|Heterozygous||A|G|63|33.0|Non-synonymous|Unprocessed|APF-G1
1794799|IGL00850|5|52760950|Y->Stop|||N/A|||MGI:1914323|Pi4k2b|phosphatidylinositol 4-kinase type 2 beta [Source:MGI Symbol;Acc:MGI:1914323]|Heterozygous||T|A|59|40.0|Non-synonymous|Unprocessed|APF-G1
1794800|IGL00850|11|79502714|N->S||||0.19|tolerated|MGI:97306, MGI:106586|Omg,nf1|neurofibromatosis 1 [Source:MGI Symbol;Acc:MGI:97306],oligodendrocyte myelin glycoprotein [Source:MGI Symbol;Acc:MGI:106586]|Heterozygous|Homozygous embryos die by day 14.5 with enlarged head and chest, pale liver, microphthalmia, cardiac defects and delayed organ development. Heterozygotes have elevated astrocyte number, predisposition to multiple tumor types and learning/memory deficits.,Mice homozygous for a null allele exhibit improved recovery from spinal cord injuries when on a mixed 129S4/SvJae C57BL/6 background.|T|C|57|38.0|Non-synonymous|Unprocessed|APF-G1
1794801|IGL00850|13|24867174|D->E||1.0|Probably damaging||deleterious|MGI:3036268|D130043k22rik|RIKEN cDNA D130043K22 gene [Source:MGI Symbol;Acc:MGI:3036268]|Heterozygous||T|G|48|37.5|Non-synonymous|Unprocessed|APF-G1
1794802|IGL00850|4|124682457|K->R||0.65|Possibly damaging|0.27|tolerated|MGI:1914455|Utp11l|UTP11-like, U3 small nucleolar ribonucleoprotein, (yeast) [Source:MGI Symbol;Acc:MGI:1914455]|Heterozygous||T|C|40|38.0|Non-synonymous|Unprocessed|APF-G1
1794803|IGL00850|14|20306350|S->R||0.94|Possibly damaging|0.08|tolerated|MGI:1914975|Nudt13|nudix (nucleoside diphosphate linked moiety X)-type motif 13 [Source:MGI Symbol;Acc:MGI:1914975]|Heterozygous||T|A|37|35.0|Non-synonymous|Unprocessed|APF-G1
1794804|IGL00850|6|3532177|Q->Stop|||N/A|||MGI:1920538|Ccdc132|coiled-coil domain containing 132 [Source:MGI Symbol;Acc:MGI:1920538]|Heterozygous||C|T|34|38.0|Non-synonymous|Unprocessed|APF-G1
1794805|IGL00850|10|119211135|V->L|||Benign|0.4|tolerated|MGI:1261820|Cand1|cullin associated and neddylation disassociated 1 [Source:MGI Symbol;Acc:MGI:1261820]|Heterozygous||C|A|32|38.5|Non-synonymous|Unprocessed|APF-G1
1794806|IGL00850|11|67090855|Y->H||0.97|Probably damaging|0.03|deleterious|MGI:1339709|Myh3|myosin, heavy polypeptide 3, skeletal muscle, embryonic [Source:MGI Symbol;Acc:MGI:1339709]|Heterozygous||T|C|26|37.0|Non-synonymous|Unprocessed|APF-G1
1794807|IGL00850|14|31087619|V->A||1.0|Probably damaging|0.01|deleterious|MGI:1923998|Pbrm1|polybromo 1 [Source:MGI Symbol;Acc:MGI:1923998]|Heterozygous|Homozygous null mice display embryonic lethality with hypoplastic cardiac ventricular chambers and malformation of the placenta.|T|C|26|35.0|Non-synonymous|Unprocessed|APF-G1
1794808|IGL00850|3|80861781|S->P||0.99|Probably damaging||deleterious|MGI:95751|Glrb|glycine receptor, beta subunit [Source:MGI Symbol;Acc:MGI:95751]|Heterozygous|Mutations in this gene result in a neurological disorder and premature death.|A|G|24|39.0|Non-synonymous|Unprocessed|APF-G1
1794809|IGL00850|9|51948649|I->N||1.0|Probably damaging|0.1|tolerated|MGI:103224|Fdx1|ferredoxin 1 [Source:MGI Symbol;Acc:MGI:103224]|Heterozygous||A|T|23|38.0|Non-synonymous|Unprocessed|APF-G1
1794810|IGL00850|2|24394286|A->V||0.01|Benign|0.17|tolerated|MGI:2674093|Psd4|pleckstrin and Sec7 domain containing 4 [Source:MGI Symbol;Acc:MGI:2674093]|Heterozygous||C|T|22|37.5|Non-synonymous|Unprocessed|APF-G1
1794811|IGL00850|8|81856750|Q->R||0.99|Probably damaging|0.12|tolerated|MGI:2158925|Inpp4b|inositol polyphosphate-4-phosphatase, type II [Source:MGI Symbol;Acc:MGI:2158925]|Heterozygous||A|G|22|38.0|Non-synonymous|Unprocessed|APF-G1
1794812|IGL00850|11|106375207|T->K||0.68|Possibly damaging|0.01|deleterious|MGI:1922823|2310007l24rik|RIKEN cDNA 2310007L24 gene [Source:MGI Symbol;Acc:MGI:1922823]|Heterozygous||C|A|20|37.5|Non-synonymous|Unprocessed|APF-G1
1794813|IGL00850|5|92951065|L->P||1.0|Probably damaging|0.01|deleterious|MGI:1351655|Shroom3|shroom family member 3 [Source:MGI Symbol;Acc:MGI:1351655]|Heterozygous|Homozygous mutation of this locus results in failed neural tube closure leading to exencephaly, acrania, facial clefting, and spina bifida. Homozygotes develop to term but die either at birth or shortly thereafter.|T|C|20|33.0|Non-synonymous|Unprocessed|APF-G1
1794814|IGL00850|1|130165077|S->N||0.05|Benign|1.0|tolerated|MGI:2443925|Thsd7b|thrombospondin, type I, domain containing 7B [Source:MGI Symbol;Acc:MGI:2443925]|Heterozygous||G|A|19|39.0|Non-synonymous|Unprocessed|APF-G1
1794815|IGL00850|2|129801992|T->A||0.94|Possibly damaging|0.03|deleterious|MGI:1914583|Stk35|serine/threonine kinase 35 [Source:MGI Symbol;Acc:MGI:1914583]|Heterozygous||A|G|19|37.0|Non-synonymous|Unprocessed|APF-G1
1794816|IGL00850|11|98222665|N->K||0.96|Probably damaging||deleterious|MGI:1098802|Cdk12|cyclin-dependent kinase 12 [Source:MGI Symbol;Acc:MGI:1098802]|Heterozygous||T|A|15|37.0|Non-synonymous|Unprocessed|APF-G1
1794817|IGL00850|17|56258355|I->V||0.36|Benign|0.16|tolerated|MGI:1335089|Fem1a|feminization 1 homolog a (C. elegans) [Source:MGI Symbol;Acc:MGI:1335089]|Heterozygous||A|G|14|34.0|Non-synonymous|Unprocessed|APF-G1
1794818|IGL00850|1|34306624|A->S||0.27|Benign|||MGI:104627|Dst|dystonin [Source:MGI Symbol;Acc:MGI:104627]|Heterozygous|Mutations in this gene produce peripheral nervous system demyelination resulting in impaired muscle function and shorter lifespan.|G|T|13|33.0|Non-synonymous|Unprocessed|APF-G1
1794819|IGL00850|5|24592261|E->G||0.46|Possibly damaging|0.08|tolerated|MGI:1917522|Chpf2|chondroitin polymerizing factor 2 [Source:MGI Symbol;Acc:MGI:1917522]|Heterozygous||A|G|12|37.0|Non-synonymous|Unprocessed|APF-G1
1794824|IGL00850|11|120720610|Disrupted splicing||||||MGI:2387183|Lrrc45|leucine rich repeat containing 45 [Source:MGI Symbol;Acc:MGI:2387183]|Heterozygous||T|C|34|39.0|Splice|Unprocessed|APF-G1
1794825|IGL00850|4|115438049|Disrupted splicing||||||MGI:3611747|Cyp4a12b|cytochrome P450, family 4, subfamily a, polypeptide 12B [Source:MGI Symbol;Acc:MGI:3611747]|Heterozygous||T|A|26|40.0|Splice|Unprocessed|APF-G1
1794826|IGL00850|5|114315071|Disrupted splicing||||||MGI:1914674|Myo1h|myosin 1H [Source:MGI Symbol;Acc:MGI:1914674]|Heterozygous||A|C|19|35.0|Splice|Unprocessed|APF-G1
1795297|IGL00851|7|120340007|F->S||1.0|Probably damaging||deleterious|MGI:2388709|Abca15|ATP-binding cassette, sub-family A (ABC1), member 15 [Source:MGI Symbol;Acc:MGI:2388709]|Heterozygous||T|C|71|38.0|Non-synonymous|Unprocessed|APF-G1
1795298|IGL00851|12|55709575|D->G||0.67|Possibly damaging|0.22|tolerated|MGI:1931050|Ralgapa1|Ral GTPase activating protein, alpha subunit 1 [Source:MGI Symbol;Acc:MGI:1931050]|Heterozygous||T|C|60|39.0|Non-synonymous|Unprocessed|APF-G1
1795299|IGL00851|16|37631695|S->F||1.0|Probably damaging|0.26|tolerated|MGI:96078|Hgd|homogentisate 1, 2-dioxygenase [Source:MGI Symbol;Acc:MGI:96078]|Heterozygous|Mutations in this gene result in high levels of urinary homogentisic acid.|C|T|54|39.0|Non-synonymous|Unprocessed|APF-G1
1795300|IGL00851|5|3591739|T->A||0.45|Possibly damaging|0.01|deleterious|MGI:2442653|C030048b08rik|RIKEN cDNA C030048B08 gene [Source:MGI Symbol;Acc:MGI:2442653]|Heterozygous||T|C|45|39.0|Non-synonymous|Unprocessed|APF-G1
1795301|IGL00851|8|93123117|I->F|||Benign|0.7|tolerated|MGI:95420|Ces1c|carboxylesterase 1C [Source:MGI Symbol;Acc:MGI:95420]|Heterozygous|Mice homozygous for a knock-out allele exhibit protection against nerve agents such as chlorpyrifos and chlorpyrifos oxon but increased sensitivity to soman coumarin.|T|A|45|38.0|Non-synonymous|Unprocessed|APF-G1
1795302|IGL00851|11|101423790|E->G||||0.01|deleterious|MGI:1916934|Aarsd1|alanyl-tRNA synthetase domain containing 1 [Source:MGI Symbol;Acc:MGI:1916934]|Heterozygous||T|C|37|39.0|Non-synonymous|Unprocessed|APF-G1
1795303|IGL00851|X|135843751|T->A||0.99|Probably damaging|0.14|tolerated|MGI:2442071|Gprasp2|G protein-coupled receptor associated sorting protein 2 [Source:MGI Symbol;Acc:MGI:2442071]|Heterozygous||A|G|37|39.0|Non-synonymous|Unprocessed|APF-G1
1795304|IGL00851|1|107159705|N->Y||1.0|Probably damaging||deleterious|MGI:2683293|Serpinb3b|serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3B [Source:MGI Symbol;Acc:MGI:2683293]|Heterozygous||T|A|32|37.0|Non-synonymous|Unprocessed|APF-G1
1795305|IGL00851|6|46484072|Y->H|||Benign|1.0|tolerated|MGI:1914047|Cntnap2|contactin associated protein-like 2 [Source:MGI Symbol;Acc:MGI:1914047]|Heterozygous|Inactivation of this gene results in molecular abnormalities within the central nervous system, but homozygous mutant mice show no overt phenotype.|T|C|32|35.0|Non-synonymous|Unprocessed|APF-G1
1795306|IGL00851|2|118728251|I->T||0.12|Benign|0.12|tolerated|MGI:107465|Plcb2|phospholipase C, beta 2 [Source:MGI Symbol;Acc:MGI:107465]|Heterozygous|Homozygous mutant mice showed an increased sensitivity to both bacterial and viral infections and exhibited abnormal taste perception in which sweet, umami, and bitter stimuli could not be sensed.|A|G|29|35.0|Non-synonymous|Unprocessed|APF-G1
1795307|IGL00851|4|116692950|R->C||0.12|Benign|0.08|tolerated|MGI:99523|Prdx1|peroxiredoxin 1 [Source:MGI Symbol;Acc:MGI:99523]|Heterozygous|Mutant mice exhibit defects in antioxidant defense that manifest as hemolytic anemia and malignancies. The phenotype is more severe in homozygous mutant mice which die prematurely.|C|T|25|38.0|Non-synonymous|Unprocessed|APF-G1
1795308|IGL00851|3|95125580|E->V||1.0|Probably damaging|0.05|deleterious|MGI:1355285|Tmod4|tropomodulin 4 [Source:MGI Symbol;Acc:MGI:1355285]|Heterozygous||A|T|22|33.0|Non-synonymous|Unprocessed|APF-G1
1795309|IGL00851|X|129971547|K->R|||Unknown|0.02|deleterious|MGI:1858500|Diap2|diaphanous homolog 2 (Drosophila) [Source:MGI Symbol;Acc:MGI:1858500]|Heterozygous||A|G|20|39.0|Non-synonymous|Unprocessed|APF-G1
1795310|IGL00851|11|67217910|T->M||1.0|Probably damaging|0.04|deleterious|MGI:1339711|Myh1|myosin, heavy polypeptide 1, skeletal muscle, adult [Source:MGI Symbol;Acc:MGI:1339711]|Heterozygous|Homozygotes for a targeted null mutation exhibit reduced growth, muscular weakness, kyphosis, and abnormal kinetics of muscle contraction and relaxation.|C|T|19|39.0|Non-synonymous|Unprocessed|APF-G1
1795311|IGL00851|17|33581964|M->L||1.0|Probably damaging|0.09|tolerated|MGI:107711|Myo1f|myosin IF [Source:MGI Symbol;Acc:MGI:107711]|Heterozygous|Mice homozygous for a knock-out allele exhibit impaired neutrophil migration and adhesion.|A|T|19|36.0|Non-synonymous|Unprocessed|APF-G1
1795312|IGL00851|11|63070400|Y->H|||Benign|0.05|deleterious|MGI:1918312|Tekt3|tektin 3 [Source:MGI Symbol;Acc:MGI:1918312]|Heterozygous|Mice homozygous for a null allele exhibit defective sperm motility.|T|C|18|34.5|Non-synonymous|Unprocessed|APF-G1
1795313|IGL00851|18|80765910|E->A||0.96|Probably damaging|0.07|tolerated|MGI:1354757|Atp9b|ATPase, class II, type 9B [Source:MGI Symbol;Acc:MGI:1354757]|Heterozygous||T|G|18|38.0|Non-synonymous|Unprocessed|APF-G1
1795314|IGL00851|10|69874833|I->T||0.33|Benign|0.03|deleterious|MGI:88026|Ank3|ankyrin 3, epithelial [Source:MGI Symbol;Acc:MGI:88026]|Heterozygous|Homozygotes for a mutation that selectively ablates gene expression in brain exhibit progressive ataxia, tremors, uncoordination, and a substantially reduced cerebellum deficient in Purkinje cells. Mutants are poor breeders and die by 4-6 months.|T|C|17|38.0|Non-synonymous|Unprocessed|APF-G1
1795315|IGL00851|1|150582301|K->E|||Benign|0.33|tolerated|MGI:2685047|Hmcn1|hemicentin 1 [Source:MGI Symbol;Acc:MGI:2685047]|Heterozygous||T|C|16|36.0|Non-synonymous|Unprocessed|APF-G1
1795316|IGL00851|16|23028830|D->G||0.99|Probably damaging|0.02|deleterious|MGI:3027157|Kng2|kininogen 2 [Source:MGI Symbol;Acc:MGI:3027157]|Heterozygous||T|C|13|40.0|Non-synonymous|Unprocessed|APF-G1
1795802|IGL00852|9|54423313|L->Stop|||N/A|||MGI:2444630|Dmxl2|Dmx-like 2 [Source:MGI Symbol;Acc:MGI:2444630]|Heterozygous||A|T|120|40.0|Non-synonymous|Unprocessed|APF-G1
1795803|IGL00852|7|48805601|S->R||0.1|Benign|0.54|tolerated|MGI:1919227|Zdhhc13|zinc finger, DHHC domain containing 13 [Source:MGI Symbol;Acc:MGI:1919227]|Heterozygous|Mice homozygous for an ENU mutation display wasting, weight loss, hair loss (alopecia), reduced bone mineral density (osteoporosis), and generalized amyloid deposition, which resulted in early death.|T|A|93|39.0|Non-synonymous|Unprocessed|APF-G1
1795804|IGL00852|3|155054569|Q->L|||Benign|0.24|tolerated|MGI:2443276|Tnni3k|TNNI3 interacting kinase [Source:MGI Symbol;Acc:MGI:2443276]|Heterozygous||T|A|81|41.0|Non-synonymous|Unprocessed|APF-G1
1795805|IGL00852|9|85713601|Y->D||0.02|Benign|0.2|tolerated|MGI:1918677|Ibtk|inhibitor of Bruton agammaglobulinemia tyrosine kinase [Source:MGI Symbol;Acc:MGI:1918677]|Heterozygous||A|C|70|37.0|Non-synonymous|Unprocessed|APF-G1
1795806|IGL00852|18|20034683|V->I||0.02|Benign|0.82|tolerated|MGI:103221|Dsc2|desmocollin 2 [Source:MGI Symbol;Acc:MGI:103221]|Heterozygous||C|T|66|39.0|Non-synonymous|Unprocessed|APF-G1
1795807|IGL00852|3|116546114|G->S||0.02|Benign|0.14|tolerated|MGI:105386|Dbt|dihydrolipoamide branched chain transacylase E2 [Source:MGI Symbol;Acc:MGI:105386]|Heterozygous|Homozygous mutation of this gene results in postnatal lethality, pallor, respiratory distress, and an increase in branched-chain amino acids in the blood and urine. Homozygotes model Maple Syrup Urine Disease.|G|A|66|40.0|Non-synonymous|Unprocessed|APF-G1
1795809|IGL00852|2|32779815|Q->L||0.56|Possibly damaging|0.03|deleterious|MGI:2447809|1700019l03rik|RIKEN cDNA 1700019L03 gene [Source:MGI Symbol;Acc:MGI:2447809]|Heterozygous||T|A|43|38.0|Non-synonymous|Unprocessed|APF-G1
1795810|IGL00852|1|65062091|R->Q||0.94|Possibly damaging|0.15|tolerated|MGI:88524|Crygd|crystallin, gamma D [Source:MGI Symbol;Acc:MGI:88524]|Heterozygous|Heterozygotes for a spontaneous mutation exhibit a dense nuclear cataract and mild microphthalmia by 2-months of age, followed by posterior capsular rupture into the posterior vitreous by 3-months. In homozygotes, the microphthalmia is more pronounced.|C|T|42|38.0|Non-synonymous|Unprocessed|APF-G1
1795811|IGL00852|X|39346630|R->Stop|||N/A|||MGI:3616461|Cypt15|cysteine-rich perinuclear theca 15 [Source:MGI Symbol;Acc:MGI:3616461]|Heterozygous||A|T|41|40.0|Non-synonymous|Unprocessed|APF-G1
1795812|IGL00852|8|90973207|Q->K|||Unknown|0.73|tolerated|MGI:1924001|Chd9|chromodomain helicase DNA binding protein 9 [Source:MGI Symbol;Acc:MGI:1924001]|Heterozygous||C|A|27|39.0|Non-synonymous|Unprocessed|APF-G1
1795813|IGL00852|10|58477901|R->Q||0.02|Benign|0.71|tolerated|MGI:894323|Ranbp2|RAN binding protein 2 [Source:MGI Symbol;Acc:MGI:894323]|Heterozygous|Mice homozygous for a gene trap allele display embryonic lethality. Heterozygous mice on some backgrounds display reduced ATP levels in the CNS, decreased glucose clearance, decreased weight gain on a high fat diet, and reduced scotopic responses.|G|A|25|39.0|Non-synonymous|Unprocessed|APF-G1
1795814|IGL00852|9|119537682|N->S||||0.08|tolerated|MGI:98251|Scn5a|sodium channel, voltage-gated, type V, alpha [Source:MGI Symbol;Acc:MGI:98251]|Heterozygous|Mice homozygous for mutations in this gene die prenatally usually during organogenesis. Heterozygous mice typically display abnormal heartbeats and defects in the function of the impulse conduction system.|T|C|23|39.0|Non-synonymous|Unprocessed|APF-G1
1795815|IGL00852|19|7682958|M->I|||Benign|1.0|tolerated|MGI:2442751|Slc22a19|solute carrier family 22 (organic anion transporter), member 19 [Source:MGI Symbol;Acc:MGI:2442751]|Heterozygous||C|T|19|40.0|Non-synonymous|Unprocessed|APF-G1
1795816|IGL00852|8|41287821|W->R||1.0|Probably damaging||deleterious|MGI:1277958|Pcm1|pericentriolar material 1 [Source:MGI Symbol;Acc:MGI:1277958]|Heterozygous||T|C|19|37.0|Non-synonymous|Unprocessed|APF-G1
1795817|IGL00852|1|63178506|G->R||0.68|Possibly damaging|0.15|tolerated|MGI:1929520|Eef1b2|eukaryotic translation elongation factor 1 beta 2 [Source:MGI Symbol;Acc:MGI:1929520]|Heterozygous||G|A|16|37.5|Non-synonymous|Unprocessed|APF-G1
1795818|IGL00852|1|67004837|L->F||1.0|Probably damaging||deleterious|MGI:1336997|Lancl1|LanC (bacterial lantibiotic synthetase component C)-like 1 [Source:MGI Symbol;Acc:MGI:1336997]|Heterozygous||G|A|14|36.5|Non-synonymous|Unprocessed|APF-G1
1795819|IGL00852|2|156503718|L->F||1.0|Probably damaging||deleterious|MGI:103010|Epb4.1l1|erythrocyte protein band 4.1-like 1 [Source:MGI Symbol;Acc:MGI:103010]|Heterozygous|Mice homozygous for a knock-out allele exhibit normal glutamatergic synapse formation, AMPAR responses and long-term potentiation.|C|T|12|38.5|Non-synonymous|Unprocessed|APF-G1
1795820|IGL00852|19|22987071|V->D||0.32|Benign|0.01|deleterious|MGI:2443101|Trpm3|transient receptor potential cation channel, subfamily M, member 3 [Source:MGI Symbol;Acc:MGI:2443101]|Heterozygous||T|A|11|39.0|Non-synonymous|Unprocessed|APF-G1
1795825|IGL00852|10|59192820|Disrupted splicing||||||MGI:1918110|Sept10|septin 10 [Source:MGI Symbol;Acc:MGI:1918110]|Heterozygous||A|G|43|39.0|Splice|Unprocessed|APF-G1
1795826|IGL00852|3|142809816|Disrupted splicing||||||MGI:109211|Pkn2|protein kinase N2 [Source:MGI Symbol;Acc:MGI:109211]|Heterozygous||T|A|24|34.5|Splice|Unprocessed|APF-G1
1795827|IGL00852|13|33897338|Disrupted splicing||||||MGI:2145481|Serpinb6c|serine (or cysteine) peptidase inhibitor, clade B, member 6c [Source:MGI Symbol;Acc:MGI:2145481]|Heterozygous||A|T|16|37.5|Splice|Unprocessed|APF-G1
1795828|IGL00852|6|50589184|Disrupted splicing||||||MGI:1918071|4921507p07rik|RIKEN cDNA 4921507P07 gene [Source:MGI Symbol;Acc:MGI:1918071]|Heterozygous||T|A|16|41.0|Splice|Unprocessed|APF-G1
1796315|IGL00857|2|3502759|Y->C||0.99|Probably damaging|0.01|deleterious|MGI:1354164|Hspa14|heat shock protein 14 [Source:MGI Symbol;Acc:MGI:1354164]|Heterozygous||T|C|115|40.0|Non-synonymous|Unprocessed|APF-G1
1796316|IGL00857|2|24003783|D->G||0.06|Benign|0.07|tolerated|MGI:2153181|Hnmt|histamine N-methyltransferase [Source:MGI Symbol;Acc:MGI:2153181]|Heterozygous||T|C|76|40.0|Non-synonymous|Unprocessed|APF-G1
1796317|IGL00857|4|59617735|N->K|||Unknown|0.58|tolerated|MGI:1919729|Hsdl2|hydroxysteroid dehydrogenase like 2 [Source:MGI Symbol;Acc:MGI:1919729]|Heterozygous||T|A|61|40.0|Non-synonymous|Unprocessed|APF-G1
1796318|IGL00857|14|73364616|N->S|||Benign|0.09|tolerated|MGI:1309517|Itm2b|integral membrane protein 2B [Source:MGI Symbol;Acc:MGI:1309517]|Heterozygous|Mice homozygous for a null mutation display increased levels of soluble APP fragments in the brain. Mice homozygous for a knock-in allele exhibit impaired oject recognition, impaired contextual conditioning, and impaired spatial working memory.|T|C|41|36.0|Non-synonymous|Unprocessed|APF-G1
1796319|IGL00857|3|98711543|E->V||0.27|Benign|0.03|deleterious|MGI:96234|Hsd3b2|hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 [Source:MGI Symbol;Acc:MGI:96234]|Heterozygous||T|A|41|39.0|Non-synonymous|Unprocessed|APF-G1
1796320|IGL00857|17|81647879|T->S|||Benign|0.23|tolerated|MGI:107956|Slc8a1|solute carrier family 8 (sodium/calcium exchanger), member 1 [Source:MGI Symbol;Acc:MGI:107956]|Heterozygous|Homozygotes for targeted null mutations have underdeveloped, nonbeating hearts with massive apoptosis of myocytes, a dilated pericardium and die around embryonic day 9.5. Heterozygotes exhibit altered responses to experimental cardiac pressure overload.|T|A|37|37.0|Non-synonymous|Unprocessed|APF-G1
1796321|IGL00857|2|76752755|T->I|||Unknown|||MGI:98864|Ttn|titin [Source:MGI Symbol;Acc:MGI:98864]|Heterozygous|Homozygous mutant mice show embryogenesis defects in frontonasal mass, first branchial arch and somites, and vascular, cardiac and skeletal muscle defects causing growth retardation, muscle weakness, abnormal posture, and premature death ranging from embryonic day 11.5 to 8 weeks of age.|G|A|35|39.0|Non-synonymous|Unprocessed|APF-G1
1796322|IGL00857|6|87056163|N->K||1.0|Probably damaging||deleterious|MGI:95698|Gfpt1|glutamine fructose-6-phosphate transaminase 1 [Source:MGI Symbol;Acc:MGI:95698]|Heterozygous||T|A|32|40.0|Non-synonymous|Unprocessed|APF-G1
1796323|IGL00857|9|85324753|V->L||0.46|Possibly damaging|0.62|tolerated|MGI:2670964|Fam46a|family with sequence similarity 46, member A [Source:MGI Symbol;Acc:MGI:2670964]|Heterozygous||C|A|31|40.0|Non-synonymous|Unprocessed|APF-G1
1796324|IGL00857|2|148782250|D->G||0.43|Possibly damaging|0.28|tolerated|MGI:1925859|8030411f24rik|RIKEN cDNA 8030411F24 gene [Source:MGI Symbol;Acc:MGI:1925859]|Heterozygous||A|G|30|39.5|Non-synonymous|Unprocessed|APF-G1
1796325|IGL00857|10|41528695|T->A||0.52|Possibly damaging|0.13|tolerated|MGI:1859568|Cd164|CD164 antigen [Source:MGI Symbol;Acc:MGI:1859568]|Heterozygous||A|G|28|39.0|Non-synonymous|Unprocessed|APF-G1
1796326|IGL00857|14|30350681|N->K||1.0|Probably damaging|1.0|tolerated|MGI:88293|Cacna1d|calcium channel, voltage-dependent, L type, alpha 1D subunit [Source:MGI Symbol;Acc:MGI:88293]|Heterozygous|Homozygotes for targeted mutations exhibit small size, hypoinsulinemia, glucose intolerance, decreased number and size of pancreatic islets, deafness with degeneration of hair cells, bradycardia, and arrhythmia.|A|T|27|37.0|Non-synonymous|Unprocessed|APF-G1
1796327|IGL00857|9|54376320|Y->C||0.26|Benign|0.17|tolerated|MGI:2444630|Dmxl2|Dmx-like 2 [Source:MGI Symbol;Acc:MGI:2444630]|Heterozygous||T|C|27|37.0|Non-synonymous|Unprocessed|APF-G1
1796328|IGL00857|3|97662343|A->V||0.01|Benign|0.28|tolerated|MGI:1336185|Prkab2|protein kinase, AMP-activated, beta 2 non-catalytic subunit [Source:MGI Symbol;Acc:MGI:1336185]|Heterozygous|Mice homozygous for a knock-out allele exhibit decreased exercise endurance, muscle force, muscle and liver glycogen, and skeletal muscle fiber size and increased susceptibility to diet induced obesity and hyperinsulinemia.|C|T|26|35.5|Non-synonymous|Unprocessed|APF-G1
1796329|IGL00857|4|48610435|V->A||1.0|Probably damaging||deleterious|MGI:1926810|Tmeff1|transmembrane protein with EGF-like and two follistatin-like domains 1 [Source:MGI Symbol;Acc:MGI:1926810]|Heterozygous||T|C|25|40.0|Non-synonymous|Unprocessed|APF-G1
1796330|IGL00857|4|109054002|I->F||0.98|Probably damaging|0.01|deleterious|MGI:1201386|Nrd1|nardilysin, N-arginine dibasic convertase, NRD convertase 1 [Source:MGI Symbol;Acc:MGI:1201386]|Heterozygous|Mice homozygous for a knock-out allele mostly die within 48 hours of birth with surviving mice exhibiting cortical thinning, enlarged lateral ventricles, hypomyelination, reduced grip strength, impaired coordination, and impaired spatial working memory.|A|T|24|37.0|Non-synonymous|Unprocessed|APF-G1
1796331|IGL00857|9|44932386|G->W||1.0|Probably damaging||deleterious|MGI:2154580|Ube4a|ubiquitination factor E4A, UFD2 homolog (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:2154580]|Heterozygous||C|A|23|39.0|Non-synonymous|Unprocessed|APF-G1
1796332|IGL00857|8|19497578|R->Q||1.0|Probably damaging|||MGI:2179200|Defb7|defensin beta 7 [Source:MGI Symbol;Acc:MGI:2179200]|Heterozygous||G|A|21|39.0|Non-synonymous|Unprocessed|APF-G1
1796333|IGL00857|10|125230934|Y->D||0.5|Possibly damaging|0.61|tolerated|MGI:1330284|Slc16a7|solute carrier family 16 (monocarboxylic acid transporters), member 7 [Source:MGI Symbol;Acc:MGI:1330284]|Heterozygous||A|C|19|40.0|Non-synonymous|Unprocessed|APF-G1
1796334|IGL00857|6|25744628|I->V|||Benign|0.53|tolerated|MGI:2141503|Pot1a|protection of telomeres 1A [Source:MGI Symbol;Acc:MGI:2141503]|Heterozygous|Mice homozygous for a gene trap allele exhibit embryonic lethality and lack inner cell mass. Mice homozygous for a knock-out allele exhibit prenatal lethality.|T|C|19|39.0|Non-synonymous|Unprocessed|APF-G1
1796335|IGL00857|6|47049424|N->K|||Benign|1.0|tolerated|MGI:1914047|Cntnap2|contactin associated protein-like 2 [Source:MGI Symbol;Acc:MGI:1914047]|Heterozygous|Inactivation of this gene results in molecular abnormalities within the central nervous system, but homozygous mutant mice show no overt phenotype.|C|A|19|40.0|Non-synonymous|Unprocessed|APF-G1
1796336|IGL00857|15|89570002|T->A||0.01|Benign|1.0|tolerated|MGI:87884|Acr|acrosin prepropeptide [Source:MGI Symbol;Acc:MGI:87884]|Heterozygous|Males homozygous for a targeted null mutation produce sperm that shows delayed fertilization in vitro. Sperm from mutant gonial cells are ineffective at fertilization in competition with normal sperm both in vitro and in vivo.|A|G|18|39.5|Non-synonymous|Unprocessed|APF-G1
1796337|IGL00857|15|101473860|H->Y|||Benign|0.11|tolerated|MGI:109362|Krt86|keratin 86 [Source:MGI Symbol;Acc:MGI:109362]|Heterozygous||C|T|18|39.0|Non-synonymous|Unprocessed|APF-G1
1796338|IGL00857|16|4953929|H->L||0.85|Possibly damaging|0.22|tolerated|MGI:1919865|Anks3|ankyrin repeat and sterile alpha motif domain containing 3 [Source:MGI Symbol;Acc:MGI:1919865]|Heterozygous||T|A|17|39.0|Non-synonymous|Unprocessed|APF-G1
1796339|IGL00857|3|73049841|L->F||1.0|Probably damaging||deleterious|MGI:2679447|Slitrk3|SLIT and NTRK-like family, member 3 [Source:MGI Symbol;Acc:MGI:2679447]|Heterozygous||G|A|16|37.5|Non-synonymous|Unprocessed|APF-G1
1796340|IGL00857|11|65178836|V->D||0.99|Probably damaging|0.01|deleterious|MGI:2137495|Myocd|myocardin [Source:MGI Symbol;Acc:MGI:2137495]|Heterozygous|Mice homozygous for a null mutation exhibit embryonic lethality and fail to form vascular smooth muscle.|A|T|12|36.0|Non-synonymous|Unprocessed|APF-G1
1796341|IGL00857|10|127898859|Q->R|||Benign|1.0|tolerated|MGI:1917311|Sdr9c7|4short chain dehydrogenase/reductase family 9C, member 7 [Source:MGI Symbol;Acc:MGI:1917311]|Heterozygous||A|G|11|40.0|Non-synonymous|Unprocessed|APF-G1
1796342|IGL00857|15|71463616|E->D||0.99|Probably damaging|0.36|tolerated|MGI:1917613|Fam135b|family with sequence similarity 135, member B [Source:MGI Symbol;Acc:MGI:1917613]|Heterozygous||T|A|10|39.5|Non-synonymous|Unprocessed|APF-G1
1796343|IGL00857|17|32489657|I->V||0.02|Benign|0.05|deleterious|MGI:2445210|Cyp4f39|cytochrome P450, family 4, subfamily f, polypeptide 39 [Source:MGI Symbol;Acc:MGI:2445210]|Heterozygous||A|G|10|38.5|Non-synonymous|Unprocessed|APF-G1
1796347|IGL00857|5|45676585|Disrupted splicing||||||MGI:1930197|Ncapg|non-SMC condensin I complex, subunit G [Source:MGI Symbol;Acc:MGI:1930197]|Heterozygous||T|A|33|40.0|Splice|Unprocessed|APF-G1
1796348|IGL00857|15|54875650|Disrupted splicing||||||MGI:1321390|Enpp2|ectonucleotide pyrophosphatase/phosphodiesterase 2 [Source:MGI Symbol;Acc:MGI:1321390]|Heterozygous|Mice homozygous for a null mutation display embryonic lethality during organogenesis, absent yolk sac vasculature, abnormal vasculature, and variable penetrance of impaired embryo turning, edema, failure of chorioallantoic fusion, neural tube malformations, and abnormal forebrain development.|A|G|25|39.0|Splice|Unprocessed|APF-G1
1796349|IGL00857|14|55561285|Disrupted splicing||||||MGI:90168|Dcaf11|DDB1 and CUL4 associated factor 11 [Source:MGI Symbol;Acc:MGI:90168]|Heterozygous||A|T|23|37.0|Splice|Unprocessed|APF-G1
1796350|IGL00857|4|118612923|Disrupted splicing||||||MGI:2686209|Wdr65|WD repeat domain 65 [Source:MGI Symbol;Acc:MGI:2686209]|Heterozygous||C|T|20|37.0|Splice|Unprocessed|APF-G1
1796821|IGL00858|1|10483994|R->S||1.0|Probably damaging|0.21|tolerated|MGI:3045348|Cpa6|carboxypeptidase A6 [Source:MGI Symbol;Acc:MGI:3045348]|Heterozygous||T|A|70|38.5|Non-synonymous|Unprocessed|APF-G1
1796822|IGL00858|6|132893152|R->S||0.01|Benign||deleterious|MGI:2681217|Tas2r113|taste receptor, type 2, member 113 [Source:MGI Symbol;Acc:MGI:2681217]|Heterozygous||C|A|55|39.0|Non-synonymous|Unprocessed|APF-G1
1796823|IGL00858|6|61810665|S->Stop|||N/A|||MGI:3045354|Fam190a|family with sequence similarity 190, member A [Source:MGI Symbol;Acc:MGI:3045354]|Heterozygous||C|A|41|40.0|Non-synonymous|Unprocessed|APF-G1
1796824|IGL00858|1|135851702|V->I||0.86|Possibly damaging|0.04|deleterious|MGI:104597|Tnnt2|troponin T2, cardiac [Source:MGI Symbol;Acc:MGI:104597]|Heterozygous|Mice homozygous for a null allele exhibit embryonic lethality during and prior to organogenesis and abnormal heart development.  Mice homozygous for an allele that lacks the lysine residue at position 210 exhibit dilated cardiomyopathy.|G|A|32|37.0|Non-synonymous|Unprocessed|APF-G1
1796825|IGL00858|19|39307656|V->D||1.0|Probably damaging||deleterious|MGI:103238|Cyp2c29|cytochrome P450, family 2, subfamily c, polypeptide 29 [Source:MGI Symbol;Acc:MGI:103238]|Heterozygous||T|A|26|39.0|Non-synonymous|Unprocessed|APF-G1
1796826|IGL00858|3|151749580|M->L||0.01|Benign|0.03|deleterious|MGI:2443016|Ifi44|interferon-induced protein 44 [Source:MGI Symbol;Acc:MGI:2443016]|Heterozygous||T|A|25|40.0|Non-synonymous|Unprocessed|APF-G1
1796827|IGL00858|8|31235705|V->F||0.78|Possibly damaging|0.2|tolerated|MGI:2384748|Fut10|fucosyltransferase 10 [Source:MGI Symbol;Acc:MGI:2384748]|Heterozygous||G|T|22|39.5|Non-synonymous|Unprocessed|APF-G1
1796828|IGL00858|2|25609771|M->L|||Benign|0.54|tolerated|MGI:1924308|4921530d09rik|RIKEN cDNA 4921530D09 gene [Source:MGI Symbol;Acc:MGI:1924308]|Heterozygous||T|A|21|38.0|Non-synonymous|Unprocessed|APF-G1
1796829|IGL00858|18|49728385|I->N||1.0|Probably damaging||deleterious|MGI:1916107|Dtwd2|DTW domain containing 2 [Source:MGI Symbol;Acc:MGI:1916107]|Heterozygous||A|T|17|36.0|Non-synonymous|Unprocessed|APF-G1
1796830|IGL00858|10|88809138|E->D|||Benign|0.59|tolerated|MGI:1917933|Utp20|UTP20, small subunit (SSU) processome component, homolog (yeast) [Source:MGI Symbol;Acc:MGI:1917933]|Heterozygous||T|A|16|38.5|Non-synonymous|Unprocessed|APF-G1
1796831|IGL00858|10|109742632|V->A||0.99|Probably damaging||deleterious|MGI:2183703|Nav3|neuron navigator 3 [Source:MGI Symbol;Acc:MGI:2183703]|Heterozygous||A|G|16|39.5|Non-synonymous|Unprocessed|APF-G1
1796832|IGL00858|1|80568003|N->S||0.02|Benign|0.12|tolerated|MGI:2146320|Dock10|dedicator of cytokinesis 10 [Source:MGI Symbol;Acc:MGI:2146320]|Heterozygous||T|C|15|38.0|Non-synonymous|Unprocessed|APF-G1
1796833|IGL00858|10|88809125|L->F||0.71|Possibly damaging|0.09|tolerated|MGI:1917933|Utp20|UTP20, small subunit (SSU) processome component, homolog (yeast) [Source:MGI Symbol;Acc:MGI:1917933]|Heterozygous||G|A|15|39.0|Non-synonymous|Unprocessed|APF-G1
1796834|IGL00858|19|45007626|W->L||0.03|Benign|0.65|tolerated|MGI:2137410|Peo1|progressive external ophthalmoplegia 1 (human) [Source:MGI Symbol;Acc:MGI:2137410]|Heterozygous||G|T|15|36.0|Non-synonymous|Unprocessed|APF-G1
1796835|IGL00858|18|61736854|T->M||0.66|Possibly damaging|0.09|tolerated|MGI:2147199|Afap1l1|actin filament associated protein 1-like 1 [Source:MGI Symbol;Acc:MGI:2147199]|Heterozygous||G|A|14|33.5|Non-synonymous|Unprocessed|APF-G1
1796836|IGL00858|10|78750569|D->G||0.08|Benign|0.17|tolerated|MGI:1918226|Ccdc105|coiled-coil domain containing 105 [Source:MGI Symbol;Acc:MGI:1918226]|Heterozygous||T|C|13|34.0|Non-synonymous|Unprocessed|APF-G1
1796837|IGL00858|10|127167764|T->A||0.01|Benign|0.48|tolerated|MGI:1342057|B4galnt1|beta-1,4-N-acetyl-galactosaminyl transferase 1 [Source:MGI Symbol;Acc:MGI:1342057]|Heterozygous|Mice homozygous for one knock-out allele lack all complex gangliosides but show normal brain histology and gross behavior with only subtle defects in neural conduction velocities. Mice homozygous for another knock-out allele exhibit male infertility due to degeneration of the seminiferous tubules.|A|G|11|37.0|Non-synonymous|Unprocessed|APF-G1
1796838|IGL00858|11|74659605|K->E||0.31|Benign|0.01|deleterious|MGI:1921398|1300001i01rik|RIKEN cDNA 1300001I01 gene [Source:MGI Symbol;Acc:MGI:1921398]|Heterozygous||A|G|11|35.0|Non-synonymous|Unprocessed|APF-G1
1796839|IGL00858|2|72198897|I->F||1.0|Probably damaging||deleterious|MGI:1917723|Rapgef4|Rap guanine nucleotide exchange factor (GEF) 4 [Source:MGI Symbol;Acc:MGI:1917723]|Heterozygous|Mice homozygous for a null allele exhibit decreased insulin granule fusion in pancreatic islet cells during the first phase of cAMP-dependent insulin granule exocytosis.|A|T|11|40.0|Non-synonymous|Unprocessed|APF-G1
1796840|IGL00858|17|29340456|D->N||1.0|Probably damaging|0.03|deleterious|MGI:1929261|Mtch1|mitochondrial carrier homolog 1 (C. elegans) [Source:MGI Symbol;Acc:MGI:1929261]|Heterozygous||C|T|10|39.5|Non-synonymous|Unprocessed|APF-G1
1796841|IGL00858|3|122173888|V->M||0.92|Possibly damaging|0.05|deleterious|MGI:109424|Abca4|ATP-binding cassette, sub-family A (ABC1), member 4 [Source:MGI Symbol;Acc:MGI:109424]|Heterozygous|Mice homozygous for targeted mutations that inactivate the gene display delayed rod dark adaptation and are a model for juvenile macular degeneration.|G|A|10|39.5|Non-synonymous|Unprocessed|APF-G1
1796846|IGL00858|14|65811924|Disrupted splicing||||||MGI:1289156|Pbk|PDZ binding kinase [Source:MGI Symbol;Acc:MGI:1289156]|Heterozygous||T|C|29|39.0|Splice|Unprocessed|APF-G1
1796847|IGL00858|5|145151282|Disrupted splicing||||||MGI:1919049|Ptcd1|pentatricopeptide repeat domain 1 [Source:MGI Symbol;Acc:MGI:1919049]|Heterozygous||A|T|21|39.0|Splice|Unprocessed|APF-G1
1796848|IGL00858|1|160088392|Disrupted splicing||||||MGI:2665790|Tnn|tenascin N [Source:MGI Symbol;Acc:MGI:2665790]|Heterozygous||C|T|12|35.5|Splice|Unprocessed|APF-G1
1796849|IGL00858|17|32911718|Disrupted splicing||||||MGI:1927669|Cyp4f14|cytochrome P450, family 4, subfamily f, polypeptide 14 [Source:MGI Symbol;Acc:MGI:1927669]|Heterozygous||A|G|12|38.5|Splice|Unprocessed|APF-G1
1797283|IGL00859|9|54423313|L->Stop|||N/A|||MGI:2444630|Dmxl2|Dmx-like 2 [Source:MGI Symbol;Acc:MGI:2444630]|Heterozygous||A|T|109|40.0|Non-synonymous|Unprocessed|APF-G1
1797284|IGL00859|7|48805601|S->R||0.1|Benign|0.54|tolerated|MGI:1919227|Zdhhc13|zinc finger, DHHC domain containing 13 [Source:MGI Symbol;Acc:MGI:1919227]|Heterozygous|Mice homozygous for an ENU mutation display wasting, weight loss, hair loss (alopecia), reduced bone mineral density (osteoporosis), and generalized amyloid deposition, which resulted in early death.|T|A|89|38.0|Non-synonymous|Unprocessed|APF-G1
1797285|IGL00859|3|116546114|G->S||0.02|Benign|0.14|tolerated|MGI:105386|Dbt|dihydrolipoamide branched chain transacylase E2 [Source:MGI Symbol;Acc:MGI:105386]|Heterozygous|Homozygous mutation of this gene results in postnatal lethality, pallor, respiratory distress, and an increase in branched-chain amino acids in the blood and urine. Homozygotes model Maple Syrup Urine Disease.|G|A|69|40.0|Non-synonymous|Unprocessed|APF-G1
1797286|IGL00859|3|155054569|Q->L|||Benign|0.24|tolerated|MGI:2443276|Tnni3k|TNNI3 interacting kinase [Source:MGI Symbol;Acc:MGI:2443276]|Heterozygous||T|A|66|40.5|Non-synonymous|Unprocessed|APF-G1
1797288|IGL00859|9|85713601|Y->D||0.02|Benign|0.2|tolerated|MGI:1918677|Ibtk|inhibitor of Bruton agammaglobulinemia tyrosine kinase [Source:MGI Symbol;Acc:MGI:1918677]|Heterozygous||A|C|64|35.5|Non-synonymous|Unprocessed|APF-G1
1797289|IGL00859|18|20034683|V->I||0.02|Benign|0.82|tolerated|MGI:103221|Dsc2|desmocollin 2 [Source:MGI Symbol;Acc:MGI:103221]|Heterozygous||C|T|62|39.0|Non-synonymous|Unprocessed|APF-G1
1797290|IGL00859|1|65062091|R->Q||0.94|Possibly damaging|0.15|tolerated|MGI:88524|Crygd|crystallin, gamma D [Source:MGI Symbol;Acc:MGI:88524]|Heterozygous|Heterozygotes for a spontaneous mutation exhibit a dense nuclear cataract and mild microphthalmia by 2-months of age, followed by posterior capsular rupture into the posterior vitreous by 3-months. In homozygotes, the microphthalmia is more pronounced.|C|T|39|39.0|Non-synonymous|Unprocessed|APF-G1
1797291|IGL00859|X|39346630|R->Stop|||N/A|||MGI:3616461|Cypt15|cysteine-rich perinuclear theca 15 [Source:MGI Symbol;Acc:MGI:3616461]|Heterozygous||A|T|39|40.0|Non-synonymous|Unprocessed|APF-G1
1797292|IGL00859|2|32779815|Q->L||0.56|Possibly damaging|0.03|deleterious|MGI:2447809|1700019l03rik|RIKEN cDNA 1700019L03 gene [Source:MGI Symbol;Acc:MGI:2447809]|Heterozygous||T|A|35|39.0|Non-synonymous|Unprocessed|APF-G1
1797293|IGL00859|10|58477901|R->Q||0.02|Benign|0.71|tolerated|MGI:894323|Ranbp2|RAN binding protein 2 [Source:MGI Symbol;Acc:MGI:894323]|Heterozygous|Mice homozygous for a gene trap allele display embryonic lethality. Heterozygous mice on some backgrounds display reduced ATP levels in the CNS, decreased glucose clearance, decreased weight gain on a high fat diet, and reduced scotopic responses.|G|A|24|39.5|Non-synonymous|Unprocessed|APF-G1
1797294|IGL00859|8|90973207|Q->K|||Unknown|0.73|tolerated|MGI:1924001|Chd9|chromodomain helicase DNA binding protein 9 [Source:MGI Symbol;Acc:MGI:1924001]|Heterozygous||C|A|22|40.0|Non-synonymous|Unprocessed|APF-G1
1797295|IGL00859|1|63178506|G->R||0.68|Possibly damaging|0.15|tolerated|MGI:1929520|Eef1b2|eukaryotic translation elongation factor 1 beta 2 [Source:MGI Symbol;Acc:MGI:1929520]|Heterozygous||G|A|21|39.0|Non-synonymous|Unprocessed|APF-G1
1797296|IGL00859|9|119537682|N->S||||0.08|tolerated|MGI:98251|Scn5a|sodium channel, voltage-gated, type V, alpha [Source:MGI Symbol;Acc:MGI:98251]|Heterozygous|Mice homozygous for mutations in this gene die prenatally usually during organogenesis. Heterozygous mice typically display abnormal heartbeats and defects in the function of the impulse conduction system.|T|C|18|39.5|Non-synonymous|Unprocessed|APF-G1
1797297|IGL00859|X|37470015|Y->N|||Unknown|0.88|tolerated|MGI:3770268|Rhox3c|reproductive homeobox 3C [Source:MGI Symbol;Acc:MGI:3770268]|Heterozygous||T|A|18|39.0|Non-synonymous|Unprocessed|APF-G1
1797298|IGL00859|19|7682958|M->I|||Benign|1.0|tolerated|MGI:2442751|Slc22a19|solute carrier family 22 (organic anion transporter), member 19 [Source:MGI Symbol;Acc:MGI:2442751]|Heterozygous||C|T|15|40.0|Non-synonymous|Unprocessed|APF-G1
1797299|IGL00859|8|41287821|W->R||1.0|Probably damaging||deleterious|MGI:1277958|Pcm1|pericentriolar material 1 [Source:MGI Symbol;Acc:MGI:1277958]|Heterozygous||T|C|12|39.5|Non-synonymous|Unprocessed|APF-G1
1797300|IGL00859|1|82289262|V->A||0.32|Benign|0.37|tolerated|MGI:99454|Irs1|insulin receptor substrate 1 [Source:MGI Symbol;Acc:MGI:99454]|Heterozygous|Homozygotes for targeted null mutations exhibit 50 percent reductions in body weights at birth and at 4 months of age, impaired glucose tolerance, and mild insulin and IGF-1 resistance.|A|G|11|38.0|Non-synonymous|Unprocessed|APF-G1
1797301|IGL00859|19|5748734|Y->Stop|||N/A|||MGI:1101355|Ltbp3|latent transforming growth factor beta binding protein 3 [Source:MGI Symbol;Acc:MGI:1101355]|Heterozygous|Homozygotes for a targeted null mutation exhibit craniofacial malformations including an overshot mandible and ossification of synchondroses. Mutants develop osteosclerosis of long bones and osteoarthritis, and, in some cases, high corticosterone levels.|C|A|10|34.0|Non-synonymous|Unprocessed|APF-G1
1797306|IGL00859|10|59192820|Disrupted splicing||||||MGI:1918110|Sept10|septin 10 [Source:MGI Symbol;Acc:MGI:1918110]|Heterozygous||A|G|48|38.5|Splice|Unprocessed|APF-G1
1797307|IGL00859|13|33897338|Disrupted splicing||||||MGI:2145481|Serpinb6c|serine (or cysteine) peptidase inhibitor, clade B, member 6c [Source:MGI Symbol;Acc:MGI:2145481]|Heterozygous||A|T|20|38.0|Splice|Unprocessed|APF-G1
1797308|IGL00859|3|142809816|Disrupted splicing||||||MGI:109211|Pkn2|protein kinase N2 [Source:MGI Symbol;Acc:MGI:109211]|Heterozygous||T|A|18|34.0|Splice|Unprocessed|APF-G1
1797309|IGL00859|1|86196314|Disrupted splicing||||||MGI:1926045|Armc9|armadillo repeat containing 9 [Source:MGI Symbol;Acc:MGI:1926045]|Heterozygous||A|G|14|38.0|Splice|Unprocessed|APF-G1
1797310|IGL00859|6|50589184|Disrupted splicing||||||MGI:1918071|4921507p07rik|RIKEN cDNA 4921507P07 gene [Source:MGI Symbol;Acc:MGI:1918071]|Heterozygous||T|A|11|40.0|Splice|Unprocessed|APF-G1
1797778|IGL00861|19|11711640|D->G|||Unknown|0.42|tolerated|MGI:2684943|Gm97|predicted gene 97 [Source:MGI Symbol;Acc:MGI:2684943]|Heterozygous||A|G|82|35.0|Non-synonymous|Unprocessed|APF-G1
1797779|IGL00861|1|87774838|G->S||0.47|Possibly damaging|0.26|tolerated|MGI:1924290|Atg16l1|autophagy-related 16-like 1 (yeast) [Source:MGI Symbol;Acc:MGI:1924290]|Heterozygous|Null homozygotes have a cellular defect in autophagy that results in lethality during the neonatal starvation period.  Mice homozygous for hypomorph alleles have Paneth cells with aberrant, disorganized granules similar to those found in patients with Crohn's disease.|G|A|60|38.0|Non-synonymous|Unprocessed|APF-G1
1797780|IGL00861|5|52538121|K->E|||Benign|1.0|tolerated|MGI:2180196|Lgi2|leucine-rich repeat LGI family, member 2 [Source:MGI Symbol;Acc:MGI:2180196]|Heterozygous||T|C|49|39.0|Non-synonymous|Unprocessed|APF-G1
1797781|IGL00861|5|107570139|M->K||0.16|Benign|0.18|tolerated|MGI:2141180|Glmn|glomulin, FKBP associated protein [Source:MGI Symbol;Acc:MGI:2141180]|Heterozygous||A|T|42|40.0|Non-synonymous|Unprocessed|APF-G1
1797782|IGL00861|2|91770926|D->E||1.0|Probably damaging|0.01|deleterious|MGI:2443564|Ambra1|autophagy/beclin 1 regulator 1 [Source:MGI Symbol;Acc:MGI:2443564]|Heterozygous|Most mice homozygous for a gene trap mutation die at E10-E14.5 with severe neural tube defects manifest as midbrain/hindbrain exencephaly and/or spina bifida and associated with impaired autophagy, accumulation of ubiquitinated proteins, abnormal cell proliferation and excessive apoptosis.|T|A|33|39.0|Non-synonymous|Unprocessed|APF-G1
1797783|IGL00861|6|83299471|I->V|||Benign|0.79|tolerated|MGI:2443220|Slc4a5|solute carrier family 4, sodium bicarbonate cotransporter, member 5 [Source:MGI Symbol;Acc:MGI:2443220]|Heterozygous||A|G|33|37.0|Non-synonymous|Unprocessed|APF-G1
1797784|IGL00861|3|116546114|G->S||0.02|Benign|0.14|tolerated|MGI:105386|Dbt|dihydrolipoamide branched chain transacylase E2 [Source:MGI Symbol;Acc:MGI:105386]|Heterozygous|Homozygous mutation of this gene results in postnatal lethality, pallor, respiratory distress, and an increase in branched-chain amino acids in the blood and urine. Homozygotes model Maple Syrup Urine Disease.|G|A|28|39.0|Non-synonymous|Unprocessed|APF-G1
1797785|IGL00861|8|31235705|V->F||0.78|Possibly damaging|0.2|tolerated|MGI:2384748|Fut10|fucosyltransferase 10 [Source:MGI Symbol;Acc:MGI:2384748]|Heterozygous||G|T|28|40.0|Non-synonymous|Unprocessed|APF-G1
1797786|IGL00861|6|130023700|V->A||1.0|Probably damaging|0.58|tolerated|MGI:101902|Klra6|killer cell lectin-like receptor, subfamily A, member 6 [Source:MGI Symbol;Acc:MGI:101902]|Heterozygous||A|G|23|39.0|Non-synonymous|Unprocessed|APF-G1
1797787|IGL00861|15|73262547|S->P||1.0|Probably damaging||deleterious|MGI:95481|Ptk2|PTK2 protein tyrosine kinase 2 [Source:MGI Symbol;Acc:MGI:95481]|Heterozygous|Mice homozygous for a null allele die before or during organogenesis with growth retardation, abnormal embryonic and extra embryonic tissue development, and abnormal vascular development.|A|G|22|39.5|Non-synonymous|Unprocessed|APF-G1
1797788|IGL00861|1|65062091|R->Q||0.94|Possibly damaging|0.15|tolerated|MGI:88524|Crygd|crystallin, gamma D [Source:MGI Symbol;Acc:MGI:88524]|Heterozygous|Heterozygotes for a spontaneous mutation exhibit a dense nuclear cataract and mild microphthalmia by 2-months of age, followed by posterior capsular rupture into the posterior vitreous by 3-months. In homozygotes, the microphthalmia is more pronounced.|C|T|20|39.0|Non-synonymous|Unprocessed|APF-G1
1797789|IGL00861|2|23399962|F->I||1.0|Probably damaging||deleterious|MGI:107491|Nxph2|neurexophilin 2 [Source:MGI Symbol;Acc:MGI:107491]|Heterozygous||T|A|20|36.0|Non-synonymous|Unprocessed|APF-G1
1797790|IGL00861|1|63178506|G->R||0.68|Possibly damaging|0.15|tolerated|MGI:1929520|Eef1b2|eukaryotic translation elongation factor 1 beta 2 [Source:MGI Symbol;Acc:MGI:1929520]|Heterozygous||G|A|15|37.0|Non-synonymous|Unprocessed|APF-G1
1797791|IGL00861|9|44249636|L->P||0.78|Possibly damaging|0.16|tolerated|MGI:2429554|Pdzd3|PDZ domain containing 3 [Source:MGI Symbol;Acc:MGI:2429554]|Heterozygous||A|G|15|38.0|Non-synonymous|Unprocessed|APF-G1
1797792|IGL00861|12|36221508|Q->L|||Benign|0.45|tolerated|MGI:1920830|1700108m19rik|RIKEN cDNA 1700108M19 gene [Source:MGI Symbol;Acc:MGI:1920830]|Heterozygous||T|A|12|38.0|Non-synonymous|Unprocessed|APF-G1
1797793|IGL00861|2|84603752|D->G|||Benign|0.62|tolerated|MGI:105100|Ctnnd1|catenin (cadherin associated protein), delta 1 [Source:MGI Symbol;Acc:MGI:105100]|Heterozygous|Mice homozygous for disruptions of this gene die shortly after birth and have morphological abnormalities of the salivary glands and lacrimal gland.|T|C|12|39.0|Non-synonymous|Unprocessed|APF-G1
1797794|IGL00861|14|32449023|Y->C||1.0|Probably damaging|0.24|tolerated|MGI:88392|Chat|choline acetyltransferase [Source:MGI Symbol;Acc:MGI:88392]|Heterozygous|Homozygous mutation of this gene results in hyperinnervation of motor neurons, abnormal morphology and patterning of neuromuscular synapses, and perinatal lethality. Mutant fetuses at E18.5 exhibit a hunched position, reduced body length, and carpoptosis (drop wrist).|T|C|11|37.0|Non-synonymous|Unprocessed|APF-G1
1797795|IGL00861|10|99129652|R->C||0.71|Possibly damaging|0.06|tolerated|MGI:1918511|Poc1b|POC1 centriolar protein homolog B (Chlamydomonas) [Source:MGI Symbol;Acc:MGI:1918511]|Heterozygous||C|T|10|39.0|Non-synonymous|Unprocessed|APF-G1
1797796|IGL00861|15|59337276|T->K||0.96|Probably damaging|0.02|deleterious|MGI:2146110|E430025e21rik|RIKEN cDNA E430025E21 gene [Source:MGI Symbol;Acc:MGI:2146110]|Heterozygous||G|T|10|36.0|Non-synonymous|Unprocessed|APF-G1
1797798|IGL00861|18|53210797|Disrupted splicing||||||MGI:1915054|Snx2|sorting nexin 2 [Source:MGI Symbol;Acc:MGI:1915054]|Heterozygous|Homozygous mutant mice are viable and fertile and do not exhibit any apparent abnormalities.|G|A|39|40.0|Splice|Unprocessed|APF-G1
1797799|IGL00861|1|110060988|Disrupted splicing||||||MGI:2442792|Cdh7|cadherin 7, type 2 [Source:MGI Symbol;Acc:MGI:2442792]|Heterozygous||C|A|30|40.0|Splice|Unprocessed|APF-G1
1797800|IGL00861|5|32967814|Disrupted splicing||||||MGI:2141101|Depdc5|DEP domain containing 5 [Source:MGI Symbol;Acc:MGI:2141101]|Heterozygous||T|C|13|37.0|Splice|Unprocessed|APF-G1
1797801|IGL00861|15|89323285|Disrupted splicing||||||MGI:2675256|Adm2|adrenomedullin 2 [Source:MGI Symbol;Acc:MGI:2675256]|Heterozygous||G|A|11|40.0|Splice|Unprocessed|APF-G1
1798259|IGL00862|17|21509098|H->Q||0.03|Benign|0.43|tolerated|MGI:99200|Zfp53|zinc finger protein 53 [Source:MGI Symbol;Acc:MGI:99200]|Heterozygous|Homozygous disruption of this locus results in pigmentation abnormalities.|T|A|37|39.0|Non-synonymous|Unprocessed|APF-G1
1798260|IGL00862|3|145024571|N->I||0.95|Possibly damaging|0.25|tolerated|MGI:1346342|Clca3|chloride channel calcium activated 3 [Source:MGI Symbol;Acc:MGI:1346342]|Heterozygous|Mice homozygous for a null allele exhibit an exacerbated mucin response.|T|A|23|38.0|Non-synonymous|Unprocessed|APF-G1
1798261|IGL00862|19|17119349|H->P||0.29|Benign|0.02|deleterious|MGI:1925004|Prune2|prune homolog 2 (Drosophila) [Source:MGI Symbol;Acc:MGI:1925004]|Heterozygous||A|C|18|38.0|Non-synonymous|Unprocessed|APF-G1
1798262|IGL00862|3|153883735|D->V||0.76|Possibly damaging|0.04|deleterious|MGI:1860077|Msh4|mutS homolog 4 (E. coli) [Source:MGI Symbol;Acc:MGI:1860077]|Heterozygous|Homozygotes for a targeted null mutation exhibit male and female sterility associated with failure to undergo pairing during meiosis.|T|A|17|39.0|Non-synonymous|Unprocessed|APF-G1
1798263|IGL00862|2|67516903|I->V|||Benign|1.0|tolerated|MGI:2685198|Xirp2|xin actin-binding repeat containing 2 [Source:MGI Symbol;Acc:MGI:2685198]|Heterozygous||A|G|15|36.0|Non-synonymous|Unprocessed|APF-G1
1798264|IGL00862|1|63178506|G->R||0.68|Possibly damaging|0.15|tolerated|MGI:1929520|Eef1b2|eukaryotic translation elongation factor 1 beta 2 [Source:MGI Symbol;Acc:MGI:1929520]|Heterozygous||G|A|14|40.0|Non-synonymous|Unprocessed|APF-G1
1798265|IGL00862|11|109953548|T->A||0.41|Benign|0.15|tolerated|MGI:1351668|Abca8b|ATP-binding cassette, sub-family A (ABC1), member 8b [Source:MGI Symbol;Acc:MGI:1351668]|Heterozygous||T|C|14|38.5|Non-synonymous|Unprocessed|APF-G1
1798266|IGL00862|13|105118684|F->L||1.0|Probably damaging||deleterious|MGI:1914013|4933425l06rik|RIKEN cDNA 4933425L06 gene [Source:MGI Symbol;Acc:MGI:1914013]|Heterozygous||T|A|14|40.0|Non-synonymous|Unprocessed|APF-G1
1798267|IGL00862|6|34938063|N->K|||Benign|0.21|tolerated|MGI:107917|Stra8|stimulated by retinoic acid gene 8 [Source:MGI Symbol;Acc:MGI:107917]|Heterozygous|Homozygous null mice display impaired meiosis.|T|A|14|37.0|Non-synonymous|Unprocessed|APF-G1
1798268|IGL00862|19|18827528|Y->C||1.0|Probably damaging||deleterious|MGI:2675603|Trpm6|transient receptor potential cation channel, subfamily M, member 6 [Source:MGI Symbol;Acc:MGI:2675603]|Heterozygous||A|G|13|39.0|Non-synonymous|Unprocessed|APF-G1
1798269|IGL00862|17|21722284|Q->K||0.25|Benign|0.08|tolerated|MGI:2679257|Zfp760|zinc finger protein 760 [Source:MGI Symbol;Acc:MGI:2679257]|Heterozygous||C|A|11|40.0|Non-synonymous|Unprocessed|APF-G1
1798270|IGL00862|7|78247177|V->D||0.99|Probably damaging||deleterious|MGI:97385|Ntrk3|neurotrophic tyrosine kinase, receptor, type 3 [Source:MGI Symbol;Acc:MGI:97385]|Heterozygous|Homozygotes for targeted mutations show a range of phenotypes including postnatal death at 2-21 days, cardiac defects, reduced numbers of dorsal root ganglia neurons and germ cells, abnormal motor coordination and posture and abnormal sensory innervation.|A|T|11|35.0|Non-synonymous|Unprocessed|APF-G1
1798271|IGL00862|8|31235705|V->F||0.78|Possibly damaging|0.2|tolerated|MGI:2384748|Fut10|fucosyltransferase 10 [Source:MGI Symbol;Acc:MGI:2384748]|Heterozygous||G|T|10|39.5|Non-synonymous|Unprocessed|APF-G1
1798272|IGL00862|9|36784478|W->Stop|||N/A|||MGI:108090|Ei24|etoposide induced 2.4 mRNA [Source:MGI Symbol;Acc:MGI:108090]|Heterozygous||C|T|10|40.5|Non-synonymous|Unprocessed|APF-G1
1798275|IGL00862|15|68258663|Disrupted splicing||||||MGI:2681865|Zfat|zinc finger and AT hook domain containing [Source:MGI Symbol;Acc:MGI:2681865]|Heterozygous||C|T|20|39.0|Splice|Unprocessed|APF-G1
1798690|IGL00863|12|78809821|D->G||0.49|Possibly damaging|0.07|tolerated|MGI:1927339|Mpp5|membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) [Source:MGI Symbol;Acc:MGI:1927339]|Heterozygous|Mice homozygous for a floxed allele activated in cortical neuron exhibit loss of cortex neurons due to premature differentiation and increased apoptosis. These mice also exhibit behavioral defects but are otherwise viable and fertile. Heterozygous mice exhibit an intermediate phenotype.|A|G|80|40.0|Non-synonymous|Unprocessed|APF-G1
1798691|IGL00863|13|12435128|V->A|||Benign|0.04|deleterious|MGI:2442524|Heatr1|HEAT repeat containing 1 [Source:MGI Symbol;Acc:MGI:2442524]|Heterozygous||T|C|55|39.0|Non-synonymous|Unprocessed|APF-G1
1798692|IGL00863|1|110949144|V->A||1.0|Probably damaging||deleterious|MGI:3588198|Cdh19|cadherin 19, type 2 [Source:MGI Symbol;Acc:MGI:3588198]|Heterozygous||A|G|49|39.0|Non-synonymous|Unprocessed|APF-G1
1798693|IGL00863|8|40985534|E->G||0.03|Benign||deleterious|MGI:1916047|Pdgfrl|platelet-derived growth factor receptor-like [Source:MGI Symbol;Acc:MGI:1916047]|Heterozygous||A|G|43|38.0|Non-synonymous|Unprocessed|APF-G1
1798694|IGL00863|18|57594086|E->V||0.98|Probably damaging|0.01|deleterious|MGI:1922694|1700011i03rik|RIKEN cDNA 1700011I03 gene [Source:MGI Symbol;Acc:MGI:1922694]|Heterozygous||A|T|40|39.0|Non-synonymous|Unprocessed|APF-G1
1798695|IGL00863|6|42141121|S->R||1.0|Probably damaging||deleterious|MGI:2681308|Tas2r139|taste receptor, type 2, member 139 [Source:MGI Symbol;Acc:MGI:2681308]|Heterozygous||T|G|39|38.0|Non-synonymous|Unprocessed|APF-G1
1798696|IGL00863|3|93797073|T->S||0.66|Possibly damaging|0.61|tolerated|MGI:3027904|Tdpoz4|TD and POZ domain containing 4 [Source:MGI Symbol;Acc:MGI:3027904]|Heterozygous||A|T|38|39.0|Non-synonymous|Unprocessed|APF-G1
1798697|IGL00863|1|65062091|R->Q||0.94|Possibly damaging|0.15|tolerated|MGI:88524|Crygd|crystallin, gamma D [Source:MGI Symbol;Acc:MGI:88524]|Heterozygous|Heterozygotes for a spontaneous mutation exhibit a dense nuclear cataract and mild microphthalmia by 2-months of age, followed by posterior capsular rupture into the posterior vitreous by 3-months. In homozygotes, the microphthalmia is more pronounced.|C|T|37|39.0|Non-synonymous|Unprocessed|APF-G1
1798698|IGL00863|18|9345444|D->E||0.48|Possibly damaging|0.27|tolerated|MGI:1915224|Ccny|cyclin Y [Source:MGI Symbol;Acc:MGI:1915224]|Heterozygous||A|T|36|38.0|Non-synonymous|Unprocessed|APF-G1
1798699|IGL00863|12|12359234|I->F|||Benign|0.07|tolerated|MGI:1261783|Fam49a|family with sequence similarity 49, member A [Source:MGI Symbol;Acc:MGI:1261783]|Heterozygous||A|T|35|38.0|Non-synonymous|Unprocessed|APF-G1
1798700|IGL00863|11|62883638|A->E||1.0|Probably damaging||deleterious|MGI:1914760|Fam18b|family with sequence similarity 18, member B [Source:MGI Symbol;Acc:MGI:1914760]|Heterozygous||C|A|34|37.5|Non-synonymous|Unprocessed|APF-G1
1798701|IGL00863|17|87027723|I->N||0.98|Probably damaging|0.04|deleterious|MGI:1929655|Cript|cysteine-rich PDZ-binding protein [Source:MGI Symbol;Acc:MGI:1929655]|Heterozygous||T|A|33|38.0|Non-synonymous|Unprocessed|APF-G1
1798702|IGL00863|10|49355928|V->A||0.98|Probably damaging||deleterious|MGI:95815|Grik2|glutamate receptor, ionotropic, kainate 2 (beta 2) [Source:MGI Symbol;Acc:MGI:95815]|Heterozygous|Homozygotes for a targeted null mutation exhibit hippocampal neurons with reduced sensitivity to kainate and reduced susceptibility to the seizure-inducing effects of kainate administration.|A|G|25|38.0|Non-synonymous|Unprocessed|APF-G1
1798703|IGL00863|13|85288429|V->A||0.02|Benign|1.0|tolerated|MGI:97860|Rasa1|RAS p21 protein activator 1 [Source:MGI Symbol;Acc:MGI:97860]|Heterozygous|Homozygotes for a targeted null mutation exhibit reduced embryonic growth associated with defects of both yolk sac and embryonic vascular systems resulting in lethality by embryonic day 10.5.|A|G|24|33.5|Non-synonymous|Unprocessed|APF-G1
1798704|IGL00863|12|101809916|V->A||0.99|Probably damaging|0.02|deleterious|MGI:1346091|Fbln5|fibulin 5 [Source:MGI Symbol;Acc:MGI:1346091]|Heterozygous|Homozygous inactivation of this locus impairs elastic fiber development. Mutant mice exhibit loose skin, lung abnormalities leading to emphysema, and cardiovascular defects affecting the aorta.|A|G|23|35.0|Non-synonymous|Unprocessed|APF-G1
1798705|IGL00863|2|58790064|E->K|||Benign|0.78|tolerated|MGI:1923904|Upp2|uridine phosphorylase 2 [Source:MGI Symbol;Acc:MGI:1923904]|Heterozygous||G|A|22|39.5|Non-synonymous|Unprocessed|APF-G1
1798706|IGL00863|2|125403219|E->D||0.04|Benign|0.03|deleterious|MGI:95489|Fbn1|fibrillin 1 [Source:MGI Symbol;Acc:MGI:95489]|Heterozygous|Lethality among homozygotes for spontaneous and targeted mutations ranges from embryonic death to death around 4 months. Abnormalities include vascular defects, excess bone growth, connective tissue hyperplasia, and lung emphysema.|T|A|21|39.0|Non-synonymous|Unprocessed|APF-G1
1798707|IGL00863|14|108911837|N->Y||1.0|Probably damaging||deleterious|MGI:2679446|Slitrk1|SLIT and NTRK-like family, member 1 [Source:MGI Symbol;Acc:MGI:2679446]|Heterozygous||T|A|18|37.0|Non-synonymous|Unprocessed|APF-G1
1798708|IGL00863|1|63178506|G->R||0.68|Possibly damaging|0.15|tolerated|MGI:1929520|Eef1b2|eukaryotic translation elongation factor 1 beta 2 [Source:MGI Symbol;Acc:MGI:1929520]|Heterozygous||G|A|16|40.0|Non-synonymous|Unprocessed|APF-G1
1798709|IGL00863|11|101370723|R->L||1.0|Probably damaging||deleterious|MGI:95607|G6pc|glucose-6-phosphatase, catalytic [Source:MGI Symbol;Acc:MGI:95607]|Heterozygous|Mice homozygous for disruptions in this gene tend to die within a couple of weeks of weaning.  Blood chemistry and glucose metabolism are abnormal as isglycogen storage.|G|T|14|37.5|Non-synonymous|Unprocessed|APF-G1
1798710|IGL00863|11|59450743|S->P|||Benign|1.0|tolerated|MGI:2144404|Jmjd4|jumonji domain containing 4 [Source:MGI Symbol;Acc:MGI:2144404]|Heterozygous||T|C|13|37.0|Non-synonymous|Unprocessed|APF-G1
1798711|IGL00863|3|27241313|P->L||1.0|Probably damaging|0.02|deleterious|MGI:2443191|Nceh1|arylacetamide deacetylase-like 1 [Source:MGI Symbol;Acc:MGI:2443191]|Heterozygous|Mice homozygous for a knock-out allele exhibit abnormal organophosphorus metabolism and cholesterol homeostasis.|C|T|13|38.0|Non-synonymous|Unprocessed|APF-G1
1798712|IGL00863|3|45380302|D->E||1.0|Probably damaging||deleterious|MGI:1338042|Pcdh10|protocadherin 10 [Source:MGI Symbol;Acc:MGI:1338042]|Heterozygous|Mice homozygous for a reporter allele die within several weeks of birth and exhibit decreased body size and defective striatal axon growth and thalamocortical projections in the ventral telencephalon.|T|A|13|38.0|Non-synonymous|Unprocessed|APF-G1
1798713|IGL00863|3|69317950|D->E||0.99|Probably damaging||deleterious|MGI:2139740|Ppm1l|protein phosphatase 1 (formerly 2C)-like [Source:MGI Symbol;Acc:MGI:2139740]|Heterozygous|Mice homozygous for a null allele display a significant increase in body weight, total fat mass and blood pressure, higher baseline plasma glucose levels, decreased free fatty acid levels, and improved glucose tolerance in male, but not female, mutant mice.|T|A|12|37.5|Non-synonymous|Unprocessed|APF-G1
1798714|IGL00863|7|44838046|Y->Stop|||N/A|||MGI:109552|Il4i1|interleukin 4 induced 1 [Source:MGI Symbol;Acc:MGI:109552]|Heterozygous|Homozygous mutation of this gene results in no obvious phenotype.|T|A|11|37.0|Non-synonymous|Unprocessed|APF-G1
1798715|IGL00863|9|108115322|I->T||0.96|Probably damaging|||MGI:1277955|Bsn|bassoon [Source:MGI Symbol;Acc:MGI:1277955]|Heterozygous|Mutants lacking functional protein exhibit impaired hippocampal and photoreceptor synaptic transmission, aberrant photoreceptor ribbon synapse formation, and spontaneous epileptic seizures.|A|G|10|38.5|Non-synonymous|Unprocessed|APF-G1
1798716|IGL00863|2|121457703|Disrupted splicing||||||MGI:1914943|2310003f16rik|RIKEN cDNA 2310003F16 gene [Source:MGI Symbol;Acc:MGI:1914943]|Heterozygous||T|C|48|37.0|Splice|Unprocessed|APF-G1
1798717|IGL00863|4|8183251|Disrupted splicing||||||MGI:88253|Car8|carbonic anhydrase 8 [Source:MGI Symbol;Acc:MGI:88253]|Heterozygous|Mice homozygous for a spontaneous deletion exhibit a wobbly side-to-side gait which is first noted at two weeks of age and persists throughout life.|A|G|20|39.5|Splice|Unprocessed|APF-G1
1799182|IGL00864|14|73363135|K->E||1.0|Probably damaging||deleterious|MGI:1309517|Itm2b|integral membrane protein 2B [Source:MGI Symbol;Acc:MGI:1309517]|Heterozygous|Mice homozygous for a null mutation display increased levels of soluble APP fragments in the brain. Mice homozygous for a knock-in allele exhibit impaired oject recognition, impaired contextual conditioning, and impaired spatial working memory.|T|C|71|40.0|Non-synonymous|Unprocessed|APF-G1
1799183|IGL00864|9|53533933|S->G||0.98|Probably damaging|0.02|deleterious|MGI:107202|Atm|ataxia telangiectasia mutated homolog (human) [Source:MGI Symbol;Acc:MGI:107202]|Heterozygous|Homozygotes for null mutations may exhibit locomotor abnormalities, motor learning deficits, growth retardation, sterility due to meiotic arrest, and susceptibility to thymic lymphomas.|T|C|70|40.0|Non-synonymous|Unprocessed|APF-G1
1799184|IGL00864|4|103235698|D->G||0.86|Possibly damaging||deleterious|MGI:1918191|4921539e11rik|RIKEN cDNA 4921539E11 gene [Source:MGI Symbol;Acc:MGI:1918191]|Heterozygous||T|C|42|39.0|Non-synonymous|Unprocessed|APF-G1
1799185|IGL00864|14|101444566|D->V||||0.02|deleterious|MGI:2429660|Tbc1d4|TBC1 domain family, member 4 [Source:MGI Symbol;Acc:MGI:2429660]|Heterozygous|Mice homozygous for a knock-in allele show a slightly reduced body size, glucose intolerance, impaired insulin sensitivity, deregulated GLUT4 trafficking, abnormal glucose uptake in muscle and adipose cells, increased testis and heart weight in male mice, and reduced spleen weight in female mice.|T|A|34|39.0|Non-synonymous|Unprocessed|APF-G1
1799186|IGL00864|1|65062091|R->Q||0.94|Possibly damaging|0.15|tolerated|MGI:88524|Crygd|crystallin, gamma D [Source:MGI Symbol;Acc:MGI:88524]|Heterozygous|Heterozygotes for a spontaneous mutation exhibit a dense nuclear cataract and mild microphthalmia by 2-months of age, followed by posterior capsular rupture into the posterior vitreous by 3-months. In homozygotes, the microphthalmia is more pronounced.|C|T|29|40.0|Non-synonymous|Unprocessed|APF-G1
1799187|IGL00864|15|9175210|S->P||1.0|Probably damaging||deleterious|MGI:2444173|Lmbrd2|LMBR1 domain containing 2 [Source:MGI Symbol;Acc:MGI:2444173]|Heterozygous||T|C|27|39.0|Non-synonymous|Unprocessed|APF-G1
1799188|IGL00864|2|73156897|D->E|||Benign|0.89|tolerated|MGI:1914309|Ola1|Obg-like ATPase 1 [Source:MGI Symbol;Acc:MGI:1914309]|Heterozygous||A|T|26|38.5|Non-synonymous|Unprocessed|APF-G1
1799189|IGL00864|6|67336754|I->T|||Benign|0.43|tolerated|MGI:1270861|Il12rb2|interleukin 12 receptor, beta 2 [Source:MGI Symbol;Acc:MGI:1270861]|Heterozygous|Mice homozygous for a knock-out allele have defects in IFN-gamma production and cytotoxic T lymphocyte and NK cytotoxicity, develop an autoimmune/lymphoproliferative disorder associated with higher susceptibility to spontaneous tumor formation, but show reduced in vivo growth of B16 melanoma tumors.|A|G|26|40.0|Non-synonymous|Unprocessed|APF-G1
1799190|IGL00864|2|76713834|S->F|||Unknown|||MGI:98864|Ttn|titin [Source:MGI Symbol;Acc:MGI:98864]|Heterozygous|Homozygous mutant mice show embryogenesis defects in frontonasal mass, first branchial arch and somites, and vascular, cardiac and skeletal muscle defects causing growth retardation, muscle weakness, abnormal posture, and premature death ranging from embryonic day 11.5 to 8 weeks of age.|G|A|24|39.5|Non-synonymous|Unprocessed|APF-G1
1799191|IGL00864|9|28901590|E->K||1.0|Probably damaging||deleterious|MGI:97397|Opcml|opioid binding protein/cell adhesion molecule-like [Source:MGI Symbol;Acc:MGI:97397]|Heterozygous||G|A|22|39.0|Non-synonymous|Unprocessed|APF-G1
1799192|IGL00864|9|28901591|E->A||1.0|Probably damaging||deleterious|MGI:97397|Opcml|opioid binding protein/cell adhesion molecule-like [Source:MGI Symbol;Acc:MGI:97397]|Heterozygous||A|C|22|39.0|Non-synonymous|Unprocessed|APF-G1
1799193|IGL00864|8|92995994|F->L|||Benign|0.29|tolerated|MGI:1270850|Slc6a2|solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 [Source:MGI Symbol;Acc:MGI:1270850]|Heterozygous|Norepinephrine homeostasis is abnormal in homozygous mutant mice. In addition to displaying altered behavior, mutant mice are hypersensitive to psychostimulants.|T|C|18|39.0|Non-synonymous|Unprocessed|APF-G1
1799194|IGL00864|11|83333158|D->A||0.58|Possibly damaging||deleterious|MGI:1919020|Ap2b1|adaptor-related protein complex 2, beta 1 subunit [Source:MGI Symbol;Acc:MGI:1919020]|Heterozygous||A|C|16|37.0|Non-synonymous|Unprocessed|APF-G1
1799195|IGL00864|4|58068533|Y->Stop|||N/A|||MGI:1928849|Svep1|sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 [Source:MGI Symbol;Acc:MGI:1928849]|Heterozygous||G|T|16|39.5|Non-synonymous|Unprocessed|APF-G1
1799196|IGL00864|9|106225007|L->P||1.0|Probably damaging|0.06|tolerated|MGI:1932389|Tlr9|toll-like receptor 9 [Source:MGI Symbol;Acc:MGI:1932389]|Heterozygous|Mice homozygous for a knock-out allele exhibit impaired immune system response to LPS, CpG, and Leishmania bazillensis infection.|T|C|16|36.0|Non-synonymous|Unprocessed|APF-G1
1799197|IGL00864|16|16780733|V->A||0.1|Benign|0.01|deleterious|MGI:1354388|Spag6|sperm associated antigen 6 [Source:MGI Symbol;Acc:MGI:1354388]|Heterozygous|Many homozygotes for a targeted null mutation exhibit reduced growth,  hydrocephaly, and lethality by 8 weeks of age. Surviving males have sperm defects and are infertile, while females show reduced fertility.|A|G|15|31.0|Non-synonymous|Unprocessed|APF-G1
1799198|IGL00864|17|29139737|S->P|||Benign|0.66|tolerated|MGI:3045302|Rab44|RAB44, member RAS oncogene family [Source:MGI Symbol;Acc:MGI:3045302]|Heterozygous||T|C|15|37.0|Non-synonymous|Unprocessed|APF-G1
1799199|IGL00864|6|115948626|K->R||0.98|Probably damaging|0.2|tolerated|MGI:2176207|H1foo|H1 histone family, member O, oocyte-specific [Source:MGI Symbol;Acc:MGI:2176207]|Heterozygous|Mice homozygous for a targeted mutation exhibit no detectable abnormalities.  Oocytes develop normally and no defects in fertility or litter sizes are observed.|A|G|15|38.0|Non-synonymous|Unprocessed|APF-G1
1799200|IGL00864|18|22522446|I->K||0.03|Benign|||MGI:2685175|Asxl3|additional sex combs like 3 (Drosophila) [Source:MGI Symbol;Acc:MGI:2685175]|Heterozygous||T|A|13|41.0|Non-synonymous|Unprocessed|APF-G1
1799201|IGL00864|1|180990451|S->P||1.0|Probably damaging||deleterious|MGI:95405|Ephx1|epoxide hydrolase 1, microsomal [Source:MGI Symbol;Acc:MGI:95405]|Heterozygous||A|G|11|39.0|Non-synonymous|Unprocessed|APF-G1
1799202|IGL00864|1|21505763|Q->L||0.99|Probably damaging||deleterious|MGI:1924937|Kcnq5|potassium voltage-gated channel, subfamily Q, member 5 [Source:MGI Symbol;Acc:MGI:1924937]|Heterozygous||T|A|10|37.5|Non-synonymous|Unprocessed|APF-G1
1799207|IGL00864|7|46515663|Disrupted splicing||||||MGI:1351630|Sergef|secretion regulating guanine nucleotide exchange factor [Source:MGI Symbol;Acc:MGI:1351630]|Heterozygous||C|A|31|30.0|Splice|Unprocessed|APF-G1
1861304|IGL00869|5|27498718|K->R||0.97|Probably damaging|0.01|deleterious|MGI:1920776, MGI:94921|Speer4b,dpp6|spermatogenesis associated glutamate (E)-rich protein 4b [Source:MGI Symbol;Acc:MGI:1920776],dipeptidylpeptidase 6 [Source:MGI Symbol;Acc:MGI:94921]|Heterozygous||T|C|255|36.0|Non-synonymous|Unprocessed|APF-G1
1861305|IGL00869|17|33649902|R->L||0.97|Probably damaging|0.04|deleterious|MGI:1926465|Hnrnpm|heterogeneous nuclear ribonucleoprotein M [Source:MGI Symbol;Acc:MGI:1926465]|Heterozygous||C|A|110|34.5|Non-synonymous|Unprocessed|APF-G1
1861306|IGL00869|5|127563242|H->Y||0.63|Possibly damaging|0.04|deleterious|MGI:2443061|Tmem132c|transmembrane protein 132C [Source:MGI Symbol;Acc:MGI:2443061]|Heterozygous||C|T|59|37.0|Non-synonymous|Unprocessed|APF-G1
1861307|IGL00869|2|24216580|T->A||0.04|Benign|0.13|tolerated|MGI:1859324|Il1f6|interleukin 1 family, member 6 [Source:MGI Symbol;Acc:MGI:1859324]|Heterozygous||A|G|53|36.0|Non-synonymous|Unprocessed|APF-G1
1861308|IGL00869|17|35864755|H->R||0.45|Possibly damaging|0.29|tolerated|MGI:2146855|Nrm|nurim (nuclear envelope membrane protein) [Source:MGI Symbol;Acc:MGI:2146855]|Heterozygous||A|G|32|35.0|Non-synonymous|Unprocessed|APF-G1
1861309|IGL00869|2|113834826|T->A||0.76|Possibly damaging|0.14|tolerated|MGI:2444300|Arhgap11a|Rho GTPase activating protein 11A [Source:MGI Symbol;Acc:MGI:2444300]|Heterozygous||T|C|26|38.5|Non-synonymous|Unprocessed|APF-G1
1861311|IGL00869|15|102358651|A->E|||Benign|0.15|tolerated|MGI:2153568|Sp7|Sp7 transcription factor 7 [Source:MGI Symbol;Acc:MGI:2153568]|Heterozygous|Mice homozygous for a reporter allele die within minutes of birth displaying cyanosis, respiratory distress, arrested osteoblast differentiation, and failure of endochondral and intramembranous bone formation.|G|T|12|35.0|Non-synonymous|Unprocessed|APF-G1
1861313|IGL00869|9|39593434|Disrupted splicing||||||MGI:2143322|Aw551984|expressed sequence AW551984 [Source:MGI Symbol;Acc:MGI:2143322]|Heterozygous||A|G|54|37.0|Splice|Unprocessed|APF-G1
1861314|IGL00869|5|115588143|Disrupted splicing||||||MGI:2444248|Gcn1l1|GCN1 general control of amino-acid synthesis 1-like 1 (yeast) [Source:MGI Symbol;Acc:MGI:2444248]|Heterozygous||T|A|48|35.0|Splice|Unprocessed|APF-G1
1861779|IGL00870|9|38047740|I->F||0.95|Possibly damaging||deleterious|MGI:3030718|Olfr884|olfactory receptor 884 [Source:MGI Symbol;Acc:MGI:3030718]|Heterozygous||A|T|235|39.0|Non-synonymous|Unprocessed|APF-G1
1861780|IGL00870|6|57210113|M->L||0.07|Benign|0.03|deleterious|MGI:2148526|Vmn1r13|vomeronasal 1 receptor 13 [Source:MGI Symbol;Acc:MGI:2148526]|Heterozygous||A|T|220|36.0|Non-synonymous|Unprocessed|APF-G1
1861781|IGL00870|13|23184477|M->I|||Benign|0.39|tolerated|MGI:2159675|Vmn1r220|vomeronasal 1 receptor 220 [Source:MGI Symbol;Acc:MGI:2159675]|Heterozygous||C|T|180|39.0|Non-synonymous|Unprocessed|APF-G1
1861782|IGL00870|17|33649902|R->L||0.97|Probably damaging|0.04|deleterious|MGI:1926465|Hnrnpm|heterogeneous nuclear ribonucleoprotein M [Source:MGI Symbol;Acc:MGI:1926465]|Heterozygous||C|A|149|35.0|Non-synonymous|Unprocessed|APF-G1
1861783|IGL00870|19|10539650|L->P||0.99|Probably damaging|0.02|deleterious|MGI:1917826|Cpsf7|cleavage and polyadenylation specific factor 7 [Source:MGI Symbol;Acc:MGI:1917826]|Heterozygous||T|C|141|36.0|Non-synonymous|Unprocessed|APF-G1
1861784|IGL00870|8|48417132|T->A||||0.6|tolerated|MGI:1345183|Odz3|odd Oz/ten-m homolog 3 (Drosophila) [Source:MGI Symbol;Acc:MGI:1345183]|Heterozygous|Mice homozygous for a null mutation display abnormal ipsilateral retinal ganglion cell projections and impaired performance in visually mediated behavioral tasks.|T|C|135|35.0|Non-synonymous|Unprocessed|APF-G1
1861785|IGL00870|9|50650869|L->P||0.99|Probably damaging||deleterious|MGI:2385311|Dlat|dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) [Source:MGI Symbol;Acc:MGI:2385311]|Heterozygous||A|G|127|37.0|Non-synonymous|Unprocessed|APF-G1
1861786|IGL00870|2|22629971|V->A||0.96|Probably damaging||deleterious|MGI:95634|Gad2|glutamic acid decarboxylase 2 [Source:MGI Symbol;Acc:MGI:95634]|Heterozygous|Homozygotes for targeted null mutations exhibit spontaneous (frequently fatal) seizures, increased anxiety-like behavior, and reduced intermale aggression. Heterozygotes show reduced aggressiveness.|T|C|98|38.0|Non-synonymous|Unprocessed|APF-G1
1861787|IGL00870|3|102189440|D->G||0.27|Benign|0.04|deleterious|MGI:2159344|Vangl1|vang-like 1 (van gogh, Drosophila) [Source:MGI Symbol;Acc:MGI:2159344]|Heterozygous|Mice homozygous for a gene trapped allele display abnormal orientation of cochlear hair cell stereociliary bundles but do not develop neural tube or cardiac outflow tract abnormalities.|T|C|98|35.0|Non-synonymous|Unprocessed|APF-G1
1861788|IGL00870|1|20571390|I->F||1.0|Probably damaging|0.03|deleterious|MGI:2155808|Pkhd1|polycystic kidney and hepatic disease 1 [Source:MGI Symbol;Acc:MGI:2155808]|Heterozygous|Mice homozygous for a mutation in this gene display variable progressive liver cysts and fibrosis, but do not display kidney cysts and are fertile.  Mice homozygous for a hypomorphic and null allele display renal, pancreatic, billiary and liver cysts.|T|A|91|35.0|Non-synonymous|Unprocessed|APF-G1
1861791|IGL00870|15|4101818|L->Q||1.0|Probably damaging||deleterious|MGI:1914291|Oxct1|3-oxoacid CoA transferase 1 [Source:MGI Symbol;Acc:MGI:1914291]|Heterozygous|Mice homozygous for a knock-out allele exhibit hyperketonemia, ketoacidosis, increased glucose oxidation in the brain, increased autophagy in the brain, and neonatal lethality.|T|A|83|38.0|Non-synonymous|Unprocessed|APF-G1
1861792|IGL00870|19|9013698|D->E||0.66|Possibly damaging|0.01|deleterious|MGI:1316648|Ahnak|AHNAK nucleoprotein (desmoyokin) [Source:MGI Symbol;Acc:MGI:1316648]|Heterozygous|Mice homozygous for one knock-out allele exhibit decreaed T cell proliferation and increased susceptibility to parasitic infection.|T|A|82|38.0|Non-synonymous|Unprocessed|APF-G1
1861793|IGL00870|5|14539983|R->W||1.0|Probably damaging|||MGI:1349390|Pclo|piccolo (presynaptic cytomatrix protein) [Source:MGI Symbol;Acc:MGI:1349390]|Heterozygous|Mice homozygous for one deletion of Pclo are viable and fertile, and display no overt abnormal phenotype. Mice homozygous for another knock-out allele exhibit some premature lethality, decreased body size, and abnormal synaptic vesicle number.|A|T|61|36.0|Non-synonymous|Unprocessed|APF-G1
1861794|IGL00870|4|52610172|S->P||0.01|Benign|0.17|tolerated|MGI:1915524|4930547c10rik|RIKEN cDNA 4930547C10 gene [Source:MGI Symbol;Acc:MGI:1915524]|Heterozygous||T|C|59|34.0|Non-synonymous|Unprocessed|APF-G1
1861795|IGL00870|4|94873081|Y->Stop|||N/A|||MGI:98664|Tek|endothelial-specific receptor tyrosine kinase [Source:MGI Symbol;Acc:MGI:98664]|Heterozygous|Homozygous mutation of this gene results in embryonic lethality during organogenesis, impaired vascular branching in the embryo and yolk sac, abnormal cardiac development, and in some cases hemorrhages.|T|A|54|39.0|Non-synonymous|Unprocessed|APF-G1
1861796|IGL00870|16|89205987|G->D|||Unknown|||MGI:1916148|Krtap20-2|keratin associated protein 20-2 [Source:MGI Symbol;Acc:MGI:1916148]|Heterozygous||G|A|53|35.0|Non-synonymous|Unprocessed|APF-G1
1861797|IGL00870|11|106171257|L->P||1.0|Probably damaging||deleterious|MGI:1919399|Strada|STE20-related kinase adaptor alpha [Source:MGI Symbol;Acc:MGI:1919399]|Heterozygous||A|G|52|35.0|Non-synonymous|Unprocessed|APF-G1
1861798|IGL00870|3|88857185|Y->H||1.0|Probably damaging|0.03|deleterious|MGI:1917579|Gon4l|gon-4-like (C.elegans) [Source:MGI Symbol;Acc:MGI:1917579]|Heterozygous|Mice homozygous for an ENU-induced allele exhibit arrested B cell development at the early pro-B cell stage.|T|C|45|35.0|Non-synonymous|Unprocessed|APF-G1
1861799|IGL00870|19|37054295|I->N||1.0|Probably damaging|||MGI:2443075|Cpeb3|cytoplasmic polyadenylation element binding protein 3 [Source:MGI Symbol;Acc:MGI:2443075]|Heterozygous||A|T|44|35.0|Non-synonymous|Unprocessed|APF-G1
1861801|IGL00870|13|56723667|D->G||0.52|Possibly damaging|0.28|tolerated|MGI:1328787|Smad5|MAD homolog 5 (Drosophila) [Source:MGI Symbol;Acc:MGI:1328787]|Heterozygous|Homozygotes for targeted null mutations exhibit vascular, craniofacial, and neural tube defects, improper turning, edema, and a deficiency of primordial germ cells. Mutants die between embryonic days 10.5 and 11.5.|A|G|41|34.0|Non-synonymous|Unprocessed|APF-G1
1861802|IGL00870|2|85062236|Q->Stop|||N/A|||MGI:2446193|Tnks1bp1|tankyrase 1 binding protein 1 [Source:MGI Symbol;Acc:MGI:2446193]|Heterozygous||C|T|40|35.0|Non-synonymous|Unprocessed|APF-G1
1861803|IGL00870|7|122055676|L->Q||1.0|Probably damaging||deleterious|MGI:1914667|Ears2|glutamyl-tRNA synthetase 2 (mitochondrial)(putative) [Source:MGI Symbol;Acc:MGI:1914667]|Heterozygous||A|T|37|32.0|Non-synonymous|Unprocessed|APF-G1
1861804|IGL00870|1|107523070|I->V||1.0|Probably damaging|0.01|deleterious|MGI:97609|Serpinb2|serine (or cysteine) peptidase inhibitor, clade B, member 2 [Source:MGI Symbol;Acc:MGI:97609]|Heterozygous|Mice homozygous for a knock-out allele exhibit a slight to mild reduction in platelets, leukocytes, lymphocytes, neutrophils, and monocytes numbers.|A|G|34|37.5|Non-synonymous|Unprocessed|APF-G1
1861805|IGL00870|15|11036215|F->S||1.0|Probably damaging||deleterious|MGI:2441827|Rxfp3|relaxin family peptide receptor 3 [Source:MGI Symbol;Acc:MGI:2441827]|Heterozygous||A|G|23|35.0|Non-synonymous|Unprocessed|APF-G1
1861806|IGL00870|15|11036305|V->A||0.98|Probably damaging||deleterious|MGI:2441827|Rxfp3|relaxin family peptide receptor 3 [Source:MGI Symbol;Acc:MGI:2441827]|Heterozygous||A|G|13|33.0|Non-synonymous|Unprocessed|APF-G1
1861807|IGL00870|7|45448013|Disrupted splicing||||||MGI:101805|Gys1|glycogen synthase 1, muscle [Source:MGI Symbol;Acc:MGI:101805]|Heterozygous|Homozygous null mice display neonatal lethality with reduced heart ventricles, dilated atria, vascular congestion, and liver hemorrhage. mice homozygous for a knock-in allele exhibit altered glycogen homeostasis.|T|C|205|35.0|Splice|Unprocessed|APF-G1
1861808|IGL00870|4|109442345|Disrupted splicing||||||MGI:2444350|Ttc39a|tetratricopeptide repeat domain 39A [Source:MGI Symbol;Acc:MGI:2444350]|Heterozygous||A|G|115|34.0|Splice|Unprocessed|APF-G1
1861809|IGL00870|2|94371733|Disrupted splicing||||||MGI:1921819|Ttc17|tetratricopeptide repeat domain 17 [Source:MGI Symbol;Acc:MGI:1921819]|Heterozygous||T|C|74|35.0|Splice|Unprocessed|APF-G1
1861810|IGL00870|8|54583660|Disrupted splicing||||||MGI:1923544|Asb5|ankyrin repeat and SOCs box-containing 5 [Source:MGI Symbol;Acc:MGI:1923544]|Heterozygous||T|C|37|40.0|Splice|Unprocessed|APF-G1
1861811|IGL00870|3|106734641|Disrupted splicing||||||MGI:2445214|4933421e11rik|RIKEN cDNA 4933421E11 gene [Source:MGI Symbol;Acc:MGI:2445214]|Heterozygous||T|C|36|35.0|Splice|Unprocessed|APF-G1
1861812|IGL00870|13|100152060|Disrupted splicing||||||MGI:1298226|Naip2|NLR family, apoptosis inhibitory protein 2 [Source:MGI Symbol;Acc:MGI:1298226]|Heterozygous||A|G|28|38.5|Splice|Unprocessed|APF-G1
1861813|IGL00870|1|63677113|Disrupted splicing||||||MGI:2685061|Dytn|dystrotelin [Source:MGI Symbol;Acc:MGI:2685061]|Heterozygous||T|C|13|37.0|Splice|Unprocessed|APF-G1
1862277|IGL00753|14|56957060|C->Stop|||N/A|||MGI:1923257|Zmym2|zinc finger, MYM-type 2 [Source:MGI Symbol;Acc:MGI:1923257]|Heterozygous||T|A|98|37.0|Non-synonymous|Unprocessed|APF-G1
1862278|IGL00753|15|47644235|Y->H||0.98|Probably damaging||deleterious|MGI:2386403|Csmd3|CUB and Sushi multiple domains 3 [Source:MGI Symbol;Acc:MGI:2386403]|Heterozygous||A|G|79|37.0|Non-synonymous|Unprocessed|APF-G1
1862279|IGL00753|6|136634470|Y->D|||Benign|0.24|tolerated|MGI:1914107|Plbd1|phospholipase B domain containing 1 [Source:MGI Symbol;Acc:MGI:1914107]|Heterozygous||A|C|59|37.0|Non-synonymous|Unprocessed|APF-G1
1862280|IGL00753|2|65683863|N->S||0.28|Benign|0.16|tolerated|MGI:98248|Scn2a1|sodium channel, voltage-gated, type II, alpha 1 [Source:MGI Symbol;Acc:MGI:98248]|Heterozygous|Homozygotes for a targeted mutation exhibit excess neuronal apoptosis (especially in the brainstem), reduced neuronal sodium channel currents in vitro, and severe hypoxia resulting in neonatal lethality.|A|G|48|39.5|Non-synonymous|Unprocessed|APF-G1
1862281|IGL00753|11|80132858|Q->K|||Benign|0.99|tolerated|MGI:2442925|Atad5|ATPase family, AAA domain containing 5 [Source:MGI Symbol;Acc:MGI:2442925]|Heterozygous||C|A|45|39.0|Non-synonymous|Unprocessed|APF-G1
1862282|IGL00753|9|78435488|P->L||1.0|Probably damaging|0.02|deleterious|MGI:2442261|E330016a19rik|RIKEN cDNA E330016A19 gene [Source:MGI Symbol;Acc:MGI:2442261]|Heterozygous||G|A|40|39.0|Non-synonymous|Unprocessed|APF-G1
1862283|IGL00753|1|55696738|S->P||0.99|Probably damaging||deleterious|MGI:3036262|Plcl1|phospholipase C-like 1 [Source:MGI Symbol;Acc:MGI:3036262]|Heterozygous||T|C|39|38.0|Non-synonymous|Unprocessed|APF-G1
1862284|IGL00753|6|29565787|I->F||0.95|Probably damaging|0.01|deleterious|MGI:1196412|Tnpo3|transportin 3 [Source:MGI Symbol;Acc:MGI:1196412]|Heterozygous||T|A|35|38.0|Non-synonymous|Unprocessed|APF-G1
1862285|IGL00753|4|116985736|W->R||0.98|Probably damaging|0.02|deleterious|MGI:1921714|Zswim5|zinc finger, SWIM domain containing 5 [Source:MGI Symbol;Acc:MGI:1921714]|Heterozygous||T|C|30|35.0|Non-synonymous|Unprocessed|APF-G1
1862286|IGL00753|11|77825151|S->P||1.0|Probably damaging|0.07|tolerated|MGI:2667185|Myo18a|myosin XVIIIA [Source:MGI Symbol;Acc:MGI:2667185]|Heterozygous||T|C|28|37.5|Non-synonymous|Unprocessed|APF-G1
1862287|IGL00753|13|8861174|R->C||1.0|Probably damaging|0.04|deleterious|MGI:1920393|Wdr37|WD repeat domain 37 [Source:MGI Symbol;Acc:MGI:1920393]|Heterozygous||G|A|28|36.5|Non-synonymous|Unprocessed|APF-G1
1862288|IGL00753|15|35372031|S->L||0.99|Probably damaging|0.03|deleterious|MGI:1916380|Vps13b|vacuolar protein sorting 13B (yeast) [Source:MGI Symbol;Acc:MGI:1916380]|Heterozygous||C|T|26|40.0|Non-synonymous|Unprocessed|APF-G1
1862289|IGL00753|7|44843085|T->A||0.02|Benign|0.07|tolerated|MGI:2449973|Tbc1d17|TBC1 domain family, member 17 [Source:MGI Symbol;Acc:MGI:2449973]|Heterozygous||T|C|25|35.0|Non-synonymous|Unprocessed|APF-G1
1862290|IGL00753|7|126767426|Y->Stop|||N/A|||MGI:1915866|Gdpd3|glycerophosphodiester phosphodiesterase domain containing 3 [Source:MGI Symbol;Acc:MGI:1915866]|Heterozygous||C|A|25|40.0|Non-synonymous|Unprocessed|APF-G1
1862291|IGL00753|9|44505627|T->K||0.13|Benign|0.57|tolerated|MGI:1933114|Bcl9l|B-cell CLL/lymphoma 9-like [Source:MGI Symbol;Acc:MGI:1933114]|Heterozygous|Mice double homozygous for conditional Bcl9 and Bcl9l alleles activated in muscle cells exhibit impaired muscle regeneration due to increased apoptosis.|C|A|24|37.0|Non-synonymous|Unprocessed|APF-G1
1862292|IGL00753|16|93769624|T->A|||Benign|0.85|tolerated|MGI:1917278|Dopey2|dopey family member 2 [Source:MGI Symbol;Acc:MGI:1917278]|Heterozygous||A|G|23|35.0|Non-synonymous|Unprocessed|APF-G1
1862293|IGL00753|6|12327529|C->Y||0.99|Probably damaging||deleterious|MGI:2685683|Thsd7a|thrombospondin, type I, domain containing 7A [Source:MGI Symbol;Acc:MGI:2685683]|Heterozygous||C|T|21|40.0|Non-synonymous|Unprocessed|APF-G1
1862294|IGL00753|13|92521118|K->Stop|||N/A|||MGI:2145181|Zfyve16|zinc finger, FYVE domain containing 16 [Source:MGI Symbol;Acc:MGI:2145181]|Heterozygous||T|A|20|40.0|Non-synonymous|Unprocessed|APF-G1
1862295|IGL00753|17|25055644|F->L||1.0|Probably damaging||deleterious|MGI:2146906|Ift140|intraflagellar transport 140 homolog (Chlamydomonas) [Source:MGI Symbol;Acc:MGI:2146906]|Heterozygous||T|A|13|38.0|Non-synonymous|Unprocessed|APF-G1
1862296|IGL00753|1|135966726|P->H||0.99|Probably damaging|0.11|tolerated|MGI:3045352|Igfn1|immunoglobulin-like and fibronectin type III domain containing 1 [Source:MGI Symbol;Acc:MGI:3045352]|Heterozygous||G|T|10|38.0|Non-synonymous|Unprocessed|APF-G1
1862297|IGL00753|9|37523549|Disrupted splicing||||||MGI:2384579|Bc024479|cDNA sequence BC024479 [Source:MGI Symbol;Acc:MGI:2384579]|Heterozygous||T|C|103|37.0|Splice|Unprocessed|APF-G1
1862763|IGL00754|10|26244527|T->A||1.0|Probably damaging|0.52|tolerated|MGI:2685469|Samd3|sterile alpha motif domain containing 3 [Source:MGI Symbol;Acc:MGI:2685469]|Heterozygous||A|G|159|38.0|Non-synonymous|Unprocessed|APF-G1
1862764|IGL00754|18|70483488|S->T|||Benign|0.41|tolerated|MGI:2156774|Stard6|StAR-related lipid transfer (START) domain containing 6 [Source:MGI Symbol;Acc:MGI:2156774]|Heterozygous||T|A|150|38.0|Non-synonymous|Unprocessed|APF-G1
1862765|IGL00754|10|20972141|G->R||0.36|Benign|0.12|tolerated|MGI:87971|Ahi1|Abelson helper integration site 1 [Source:MGI Symbol;Acc:MGI:87971]|Heterozygous|Mouse embryonic fibroblasts homozygous for one knock-out allele exhibit reduced and abnormal cilia.  Mice homozygous for another knock-out allele exhibit premature death and abnormal kidney morphology and physiology.|G|A|85|40.0|Non-synonymous|Unprocessed|APF-G1
1862766|IGL00754|17|22851957|R->G||0.01|Benign|0.04|deleterious|MGI:2445132|Zfp945|zinc finger protein 945 [Source:MGI Symbol;Acc:MGI:2445132]|Heterozygous||T|C|84|40.0|Non-synonymous|Unprocessed|APF-G1
1862767|IGL00754|12|38438568|N->K||0.69|Possibly damaging|0.07|tolerated|MGI:2442474|Dgkb|diacylglycerol kinase, beta [Source:MGI Symbol;Acc:MGI:2442474]|Heterozygous|Mice homozygous for a transposon distruption have defects in long term potentiation, synapase morphology, and in spatial reference and working memory.|C|A|80|39.0|Non-synonymous|Unprocessed|APF-G1
1862768|IGL00754|15|99322670|T->I||0.4|Benign|0.4|tolerated|MGI:109569|Fmnl3|formin-like 3 [Source:MGI Symbol;Acc:MGI:109569]|Heterozygous||G|A|78|38.0|Non-synonymous|Unprocessed|APF-G1
1862769|IGL00754|19|47103782|F->I||0.62|Possibly damaging|0.35|tolerated|MGI:1341788|Pdcd11|programmed cell death 11 [Source:MGI Symbol;Acc:MGI:1341788]|Heterozygous||T|A|73|38.0|Non-synonymous|Unprocessed|APF-G1
1862770|IGL00754|9|78435488|P->L||1.0|Probably damaging|0.02|deleterious|MGI:2442261|E330016a19rik|RIKEN cDNA E330016A19 gene [Source:MGI Symbol;Acc:MGI:2442261]|Heterozygous||G|A|72|38.0|Non-synonymous|Unprocessed|APF-G1
1862771|IGL00754|6|129641426|S->R||0.99|Probably damaging|0.01|deleterious|MGI:1929720|Klrc3|killer cell lectin-like receptor subfamily C, member 3 [Source:MGI Symbol;Acc:MGI:1929720]|Heterozygous||A|T|56|37.0|Non-synonymous|Unprocessed|APF-G1
1862772|IGL00754|19|11667705|H->Q|||Benign|||MGI:2149290|Oosp1|oocyte secreted protein 1 [Source:MGI Symbol;Acc:MGI:2149290]|Heterozygous||A|T|46|39.0|Non-synonymous|Unprocessed|APF-G1
1862773|IGL00754|8|34124554|T->A||0.15|Benign|0.06|tolerated|MGI:2685017|Mboat4|membrane bound O-acyltransferase domain containing 4 [Source:MGI Symbol;Acc:MGI:2685017]|Heterozygous||A|G|46|35.0|Non-synonymous|Unprocessed|APF-G1
1862774|IGL00754|9|120494620|C->F||0.03|Benign|0.72|tolerated|MGI:1916219|Eif1b|eukaryotic translation initiation factor 1B [Source:MGI Symbol;Acc:MGI:1916219]|Heterozygous||G|T|45|37.0|Non-synonymous|Unprocessed|APF-G1
1862775|IGL00754|5|34499299|I->V|||Benign|1.0|tolerated|MGI:2386643|Tnip2|TNFAIP3 interacting protein 2 [Source:MGI Symbol;Acc:MGI:2386643]|Heterozygous|Mice homozygous for a null allele have impaired IL-1 response and macrophage physiology.|T|C|43|37.0|Non-synonymous|Unprocessed|APF-G1
1862776|IGL00754|5|114415287|S->P||1.0|Probably damaging|0.01|deleterious|MGI:1891295|Ube3b|ubiquitin protein ligase E3B [Source:MGI Symbol;Acc:MGI:1891295]|Heterozygous||T|C|43|36.0|Non-synonymous|Unprocessed|APF-G1
1862777|IGL00754|9|104174498|L->Stop|||N/A|||MGI:2676368|Dnajc13|DnaJ (Hsp40) homolog, subfamily C, member 13 [Source:MGI Symbol;Acc:MGI:2676368]|Heterozygous||A|T|37|39.0|Non-synonymous|Unprocessed|APF-G1
1862778|IGL00754|2|76782085|I->T||0.79|Possibly damaging|||MGI:98864|Ttn|titin [Source:MGI Symbol;Acc:MGI:98864]|Heterozygous|Homozygous mutant mice show embryogenesis defects in frontonasal mass, first branchial arch and somites, and vascular, cardiac and skeletal muscle defects causing growth retardation, muscle weakness, abnormal posture, and premature death ranging from embryonic day 11.5 to 8 weeks of age.|A|G|32|40.5|Non-synonymous|Unprocessed|APF-G1
1862779|IGL00754|4|32641036|M->V|||Benign|1.0|tolerated|MGI:1349399|Casp8ap2|caspase 8 associated protein 2 [Source:MGI Symbol;Acc:MGI:1349399]|Heterozygous||A|G|31|36.0|Non-synonymous|Unprocessed|APF-G1
1862780|IGL00754|7|144597231|I->V||1.0|Probably damaging|0.23|tolerated|MGI:2142149|Ano1|anoctamin 1, calcium activated chloride channel [Source:MGI Symbol;Acc:MGI:2142149]|Heterozygous|Mice homozygous for a knockout allele exhibit postnatal death associated with aerophagia, slow postnatal weight gain, cyanosis, and abnormal tracheal morphology.|T|C|29|39.0|Non-synonymous|Unprocessed|APF-G1
1862781|IGL00754|8|122575493|Q->R||0.14|Benign|0.55|tolerated|MGI:88061|Aprt|adenine phosphoribosyl transferase [Source:MGI Symbol;Acc:MGI:88061]|Heterozygous|Most homozygous null mutants may die by 6 months of age with highly abnormal kidney morphology and kidney tubule obstructions depending on the genetic background. Mice have elevated urinary 2,8-hydroxyadenine and crystalline deposits in kidney. Severity varies by genetic background.|T|C|27|35.0|Non-synonymous|Unprocessed|APF-G1
1862782|IGL00754|10|12663492|V->A||0.08|Benign|0.12|tolerated|MGI:104631|Utrn|utrophin [Source:MGI Symbol;Acc:MGI:104631]|Heterozygous|Homozygous null mutants have reduced density of acetylcholine receptors and reduced number of junctional folds at neuromuscular junctions. Mice homozygous for utrophin and dystrophin knockouts die prematurely with severe, progressive muscular dystrophy.|A|G|25|38.0|Non-synonymous|Unprocessed|APF-G1
1862783|IGL00754|2|120030356|G->R||0.61|Possibly damaging|0.48|tolerated|MGI:2384819|Pla2g4b|phospholipase A2, group IVB (cytosolic) [Source:MGI Symbol;Acc:MGI:2384819]|Heterozygous||G|A|24|35.0|Non-synonymous|Unprocessed|APF-G1
1862784|IGL00754|1|54987486|F->L||0.99|Probably damaging||deleterious|MGI:1932339|Sf3b1|splicing factor 3b, subunit 1 [Source:MGI Symbol;Acc:MGI:1932339]|Heterozygous|Homozygous null embryos die around the 16- to 32-cell stage.  Heterozygous mice exhibit various skeletal transformations.|A|G|22|39.5|Non-synonymous|Unprocessed|APF-G1
1862785|IGL00754|15|85777642|L->S||0.92|Possibly damaging||deleterious|MGI:104740|Ppara|peroxisome proliferator activated receptor alpha [Source:MGI Symbol;Acc:MGI:104740]|Heterozygous|Homozygotes for a targeted null mutation exhibit loss of diurnal variation in hepatic fatty acid and cholesterol synthesis, increased hepatic lipid and gonadal adipose stores, impaired skin wound healing, and altered metabolic responses to starvation.|T|C|21|39.0|Non-synonymous|Unprocessed|APF-G1
1862786|IGL00754|16|35839371|D->G||0.19|Benign|0.04|deleterious|MGI:1919489|Parp14|poly (ADP-ribose) polymerase family, member 14 [Source:MGI Symbol;Acc:MGI:1919489]|Heterozygous||T|C|20|37.5|Non-synonymous|Unprocessed|APF-G1
1862787|IGL00754|1|193115001|N->K||1.0|Probably damaging|0.02|deleterious|MGI:2138080|Diexf|digestive organ expansion factor homolog (zebrafish) [Source:MGI Symbol;Acc:MGI:2138080]|Heterozygous||G|T|18|37.5|Non-synonymous|Unprocessed|APF-G1
1862788|IGL00754|1|87195784|E->A||0.02|Benign|0.38|tolerated|MGI:87893|Chrnd|cholinergic receptor, nicotinic, delta polypeptide [Source:MGI Symbol;Acc:MGI:87893]|Heterozygous||A|C|17|37.0|Non-synonymous|Unprocessed|APF-G1
1862789|IGL00754|2|157819541|S->C||0.41|Benign|0.04|deleterious|MGI:1913892|Ctnnbl1|catenin, beta like 1 [Source:MGI Symbol;Acc:MGI:1913892]|Heterozygous||A|T|17|35.0|Non-synonymous|Unprocessed|APF-G1
1862790|IGL00754|4|130137233|V->A||1.0|Probably damaging|0.01|deleterious|MGI:2385650|Hcrtr1|hypocretin (orexin) receptor 1 [Source:MGI Symbol;Acc:MGI:2385650]|Heterozygous|Mice homozygous for one null allele display increased susceptibility to pharmacologically induced seizures. Mice homozygous for a second null allele display a decrease in depression like behavior.|A|G|13|36.0|Non-synonymous|Unprocessed|APF-G1
1862791|IGL00754|11|22247967|Disrupted splicing||||||MGI:2667252|Ehbp1|EH domain binding protein 1 [Source:MGI Symbol;Acc:MGI:2667252]|Heterozygous||A|G|274|37.0|Splice|Unprocessed|APF-G1
1862792|IGL00754|11|85495823|Disrupted splicing||||||MGI:2385848|Bcas3|breast carcinoma amplified sequence 3 [Source:MGI Symbol;Acc:MGI:2385848]|Heterozygous||T|A|110|38.0|Splice|Unprocessed|APF-G1
1863258|IGL00755|4|19580401|N->K|||Benign|0.32|tolerated|MGI:1913552|Fam82b|family with sequence similarity 82, member B [Source:MGI Symbol;Acc:MGI:1913552]|Heterozygous||T|A|289|39.0|Non-synonymous|Unprocessed|APF-G1
1863259|IGL00755|15|5098941|T->I||0.87|Possibly damaging|0.04|deleterious|MGI:3032959|Card6|caspase recruitment domain family, member 6 [Source:MGI Symbol;Acc:MGI:3032959]|Heterozygous||G|A|103|37.0|Non-synonymous|Unprocessed|APF-G1
1863260|IGL00755|11|9542102|Y->C||1.0|Probably damaging|||MGI:2388707|Abca13|ATP-binding cassette, sub-family A (ABC1), member 13 [Source:MGI Symbol;Acc:MGI:2388707]|Heterozygous||A|G|71|35.0|Non-synonymous|Unprocessed|APF-G1
1863261|IGL00755|12|24957646|V->E||0.26|Benign|0.25|tolerated|MGI:1914466|Mboat2|membrane bound O-acyltransferase domain containing 2 [Source:MGI Symbol;Acc:MGI:1914466]|Heterozygous||T|A|71|37.0|Non-synonymous|Unprocessed|APF-G1
1863262|IGL00755|7|20023522|D->V||1.0|Probably damaging||deleterious|MGI:2675377|Nlrp9b|NLR family, pyrin domain containing 9B [Source:MGI Symbol;Acc:MGI:2675377]|Heterozygous||A|T|52|37.5|Non-synonymous|Unprocessed|APF-G1
1863263|IGL00755|11|26470916|V->I|||Benign|1.0|tolerated|MGI:1914280|Fancl|Fanconi anemia, complementation group L [Source:MGI Symbol;Acc:MGI:1914280]|Heterozygous|Homozygosity for mutations that inactivate the allele results in male and female infertility due to a defects in primordial germ cell proliferation. Homozygosity is embryonic lethal on some backgrounds.|G|A|47|37.0|Non-synonymous|Unprocessed|APF-G1
1863264|IGL00755|19|25051509|K->E||0.89|Possibly damaging|0.01|deleterious|MGI:1921396|Dock8|dedicator of cytokinesis 8 [Source:MGI Symbol;Acc:MGI:1921396]|Heterozygous|Mice homozygous for inactivating mutations of this gene exhibit loss of marginal zone B cells, decrease in peritoneal B1 cells and peripheral naive T cells, failure of sustained antibody response after immunization, failure of germinal center persistence, and failure of B cell affinity maturation.|A|G|45|36.0|Non-synonymous|Unprocessed|APF-G1
1863265|IGL00755|19|47609010|C->S||1.0|Probably damaging||deleterious|MGI:103241|Slk|STE20-like kinase (yeast) [Source:MGI Symbol;Acc:MGI:103241]|Heterozygous||T|A|39|39.0|Non-synonymous|Unprocessed|APF-G1
1863266|IGL00755|6|65703258|P->S||1.0|Probably damaging||deleterious|MGI:1915419|A930038c07rik|RIKEN cDNA A930038C07 gene [Source:MGI Symbol;Acc:MGI:1915419]|Heterozygous||C|T|38|40.0|Non-synonymous|Unprocessed|APF-G1
1863267|IGL00755|X|167374142|I->N||0.74|Possibly damaging||deleterious|MGI:97776|Prps2|phosphoribosyl pyrophosphate synthetase 2 [Source:MGI Symbol;Acc:MGI:97776]|Heterozygous||A|T|35|37.0|Non-synonymous|Unprocessed|APF-G1
1863268|IGL00755|6|54520709|D->V||0.12|Benign|0.08|tolerated|MGI:1917188|Scrn1|secernin 1 [Source:MGI Symbol;Acc:MGI:1917188]|Heterozygous||T|A|31|34.0|Non-synonymous|Unprocessed|APF-G1
1863269|IGL00755|3|66255010|E->K||1.0|Probably damaging||deleterious|MGI:1920039|Veph1|ventricular zone expressed PH domain homolog 1 (zebrafish) [Source:MGI Symbol;Acc:MGI:1920039]|Heterozygous|Mice homozygous for a disruption in this gene appear normal.|C|T|30|36.5|Non-synonymous|Unprocessed|APF-G1
1863270|IGL00755|1|65062091|R->Q||0.94|Possibly damaging|0.15|tolerated|MGI:88524|Crygd|crystallin, gamma D [Source:MGI Symbol;Acc:MGI:88524]|Heterozygous|Heterozygotes for a spontaneous mutation exhibit a dense nuclear cataract and mild microphthalmia by 2-months of age, followed by posterior capsular rupture into the posterior vitreous by 3-months. In homozygotes, the microphthalmia is more pronounced.|C|T|26|38.0|Non-synonymous|Unprocessed|APF-G1
1863271|IGL00755|6|124318657|N->S||0.1|Benign|0.32|tolerated|MGI:2135946|Cd163|CD163 antigen [Source:MGI Symbol;Acc:MGI:2135946]|Heterozygous||A|G|26|38.0|Non-synonymous|Unprocessed|APF-G1
1863272|IGL00755|5|22060380|V->A||||0.41|tolerated|MGI:103022|Reln|reelin [Source:MGI Symbol;Acc:MGI:103022]|Heterozygous|Homozygotes for most spontaneous or ENU-induced mutations show impaired righting responses, ataxia, tremors, and cerebellum and hippocampus abnormalities. Some mutants show postnatal or premature death and decreased body size while others have abnormal retinas or olfactory bulbs or infertility.|A|G|20|38.0|Non-synonymous|Unprocessed|APF-G1
1863273|IGL00755|3|116618328|E->K||0.98|Probably damaging|0.01|deleterious|MGI:1920026|Sass6|spindle assembly 6 homolog (C. elegans) [Source:MGI Symbol;Acc:MGI:1920026]|Heterozygous||G|A|16|35.0|Non-synonymous|Unprocessed|APF-G1
1863274|IGL00755|6|47880390|P->S||1.0|Probably damaging||deleterious|MGI:2141413|Zfp282|zinc finger protein 282 [Source:MGI Symbol;Acc:MGI:2141413]|Heterozygous||C|T|15|38.0|Non-synonymous|Unprocessed|APF-G1
1863275|IGL00755|10|100531104|T->A||0.78|Possibly damaging|0.14|tolerated|MGI:2384917|Cep290|centrosomal protein 290 [Source:MGI Symbol;Acc:MGI:2384917]|Heterozygous|Mice homozygous for a spontaneous in-frame deletion display mislocalization of ciliary and phototransduction proteins resulting in early-onset retinal degeneration.|A|G|14|39.0|Non-synonymous|Unprocessed|APF-G1
1863276|IGL00755|14|103194621|V->A||0.18|Benign|0.6|tolerated|MGI:2179432|Mycbp2|MYC binding protein 2 [Source:MGI Symbol;Acc:MGI:2179432]|Heterozygous|Mice homozygous for a targeted allele exhibit neonatal lethality, defective diaphragm innervation, abnormal brain morphology and defective axonal guidance.|A|G|13|38.0|Non-synonymous|Unprocessed|APF-G1
1863277|IGL00755|7|125923426|F->S||1.0|Probably damaging|0.03|deleterious|MGI:2685483|Gsg1l|GSG1-like [Source:MGI Symbol;Acc:MGI:2685483]|Heterozygous||A|G|12|39.0|Non-synonymous|Unprocessed|APF-G1
1863278|IGL00755|6|73212434|Disrupted splicing||||||MGI:107744|Dnahc6|dynein, axonemal, heavy chain 6 [Source:MGI Symbol;Acc:MGI:107744]|Heterozygous||A|T|36|34.5|Splice|Unprocessed|APF-G1
1863279|IGL00755|18|65957095|Disrupted splicing||||||MGI:2685803|Cplx4|complexin 4 [Source:MGI Symbol;Acc:MGI:2685803]|Heterozygous||T|A|29|35.0|Splice|Unprocessed|APF-G1
1863716|IGL00756|2|21212612|H->Q||0.04|Benign|0.04|deleterious|MGI:2139347|Thnsl1|threonine synthase-like 1 (bacterial) [Source:MGI Symbol;Acc:MGI:2139347]|Heterozygous||T|A|79|39.0|Non-synonymous|Unprocessed|APF-G1
1863717|IGL00756|7|135698731|S->T||0.18|Benign|0.05|deleterious|MGI:106035|Mki67|antigen identified by monoclonal antibody Ki 67 [Source:MGI Symbol;Acc:MGI:106035]|Heterozygous||A|T|76|38.0|Non-synonymous|Unprocessed|APF-G1
1863718|IGL00756|X|95642201|Q->L||0.99|Probably damaging|0.29|tolerated|MGI:2679294|Zc4h2|zinc finger, C4H2 domain containing [Source:MGI Symbol;Acc:MGI:2679294]|Heterozygous||T|A|57|37.0|Non-synonymous|Unprocessed|APF-G1
1863719|IGL00756|14|16443791|E->Stop|||N/A|||MGI:97857|Rarb|retinoic acid receptor, beta [Source:MGI Symbol;Acc:MGI:97857]|Heterozygous|Homozygotes for a targeted null mutation exhibit reduced growth, but are otherwise normal. Rarb/Rara double knockouts exhibit impaired vitamin A signaling and develop urogenital malformations, including renal hypoplasia and hydronephrosis.|C|A|41|38.0|Non-synonymous|Unprocessed|APF-G1
1863720|IGL00756|6|73123771|F->L||0.13|Benign|0.42|tolerated|MGI:107744|Dnahc6|dynein, axonemal, heavy chain 6 [Source:MGI Symbol;Acc:MGI:107744]|Heterozygous||A|C|33|41.0|Non-synonymous|Unprocessed|APF-G1
1863721|IGL00756|14|62403209|H->R|||Benign|0.07|tolerated|MGI:2660873|Gucy1b2|guanylate cyclase 1, soluble, beta 2 [Source:MGI Symbol;Acc:MGI:2660873]|Heterozygous||T|C|30|35.0|Non-synonymous|Unprocessed|APF-G1
1863722|IGL00756|13|98686426|R->S|||Benign|0.42|tolerated|MGI:2685751|Tmem171|transmembrane protein 171 [Source:MGI Symbol;Acc:MGI:2685751]|Heterozygous||T|A|26|33.0|Non-synonymous|Unprocessed|APF-G1
1863723|IGL00756|1|24322942|K->N||0.41|Benign|0.42|tolerated|MGI:1095415|Col19a1|collagen, type XIX, alpha 1 [Source:MGI Symbol;Acc:MGI:1095415]|Heterozygous|Homozygous null mice display postnatal lethality resulting from impaired swallowing, abnormal esophageal muscle development, and impaired muscle relaxation.|T|A|24|37.5|Non-synonymous|Unprocessed|APF-G1
1863724|IGL00756|4|56829544|N->K||0.89|Possibly damaging|0.02|deleterious|MGI:1859649|Ctnnal1|catenin (cadherin associated protein), alpha-like 1 [Source:MGI Symbol;Acc:MGI:1859649]|Heterozygous||A|T|23|39.0|Non-synonymous|Unprocessed|APF-G1
1863725|IGL00756|2|104787671|M->T||0.12|Benign|0.11|tolerated|MGI:2138986|Qser1|glutamine and serine rich 1 [Source:MGI Symbol;Acc:MGI:2138986]|Heterozygous||A|G|20|37.0|Non-synonymous|Unprocessed|APF-G1
1863726|IGL00756|3|36908218|H->Q||0.98|Probably damaging|0.07|tolerated|MGI:2444631|4932438a13rik|RIKEN cDNA 4932438A13 gene [Source:MGI Symbol;Acc:MGI:2444631]|Heterozygous||C|A|20|36.0|Non-synonymous|Unprocessed|APF-G1
1863727|IGL00756|5|108705953|K->E||0.34|Benign|0.34|tolerated|MGI:2150920|Fgfrl1|fibroblast growth factor receptor-like 1 [Source:MGI Symbol;Acc:MGI:2150920]|Heterozygous|Mice homozygous for a null allele exhibit neonatal lethality associated with irregular breathing, cyanosis, a thin diaphragm and lack of spontaneous movement.|A|G|20|34.5|Non-synonymous|Unprocessed|APF-G1
1863728|IGL00756|4|104727878|K->R|||Benign|0.74|tolerated|MGI:108554|Dab1|disabled homolog 1 (Drosophila) [Source:MGI Symbol;Acc:MGI:108554]|Heterozygous|Homozygous null display unstable gait and whole-body tremor with a hypoplastic cerebellum devoid of folia, a probable consequence of defective neuronal migration.|A|G|14|38.5|Non-synonymous|Unprocessed|APF-G1
1863729|IGL00756|5|8976072|R->L||1.0|Probably damaging|0.02|deleterious|MGI:1921364|Crot|carnitine O-octanoyltransferase [Source:MGI Symbol;Acc:MGI:1921364]|Heterozygous||C|A|12|36.5|Non-synonymous|Unprocessed|APF-G1
1863730|IGL00756|6|83332486|Y->N||1.0|Probably damaging||deleterious|MGI:2442631|Mobkl1b|MOB1, Mps One Binder kinase activator-like 1B (yeast) [Source:MGI Symbol;Acc:MGI:2442631]|Heterozygous||T|A|12|36.0|Non-synonymous|Unprocessed|APF-G1
1863731|IGL00756|3|87783697|E->K||0.08|Benign|0.42|tolerated|MGI:97383|Ntrk1|neurotrophic tyrosine kinase, receptor, type 1 [Source:MGI Symbol;Acc:MGI:97383]|Heterozygous|Homozygous null mutations result in premature death due to severe sensory and sympathetic neuropathies. A conditional mutant mouse exhibits defects in mast cell and B cell physiology. Homozygotes for a point mutation are normal, but are subject to pharmacological control of signalling.|C|T|11|39.0|Non-synonymous|Unprocessed|APF-G1
1863732|IGL00756|2|48873052|Disrupted splicing||||||MGI:102806|Acvr2a|activin receptor IIA [Source:MGI Symbol;Acc:MGI:102806]|Heterozygous|While most mice homozygous for targeted mutations that inactivate this gene appear normal, a few display skeletal and facial abnormalities. As adults, follicle-stimulating hormone is suppressed, affecting reproduction.|A|T|77|37.0|Splice|Unprocessed|APF-G1
1863733|IGL00756|15|8264447|Disrupted splicing||||||MGI:1920942|2410089e03rik|RIKEN cDNA 2410089E03 gene [Source:MGI Symbol;Acc:MGI:1920942]|Heterozygous||A|G|37|35.0|Splice|Unprocessed|APF-G1
1864162|IGL00757|9|3460054|A->S||1.0|Probably damaging||deleterious|MGI:1918023|Cwf19l2|CWF19-like 2, cell cycle control (S. pombe) [Source:MGI Symbol;Acc:MGI:1918023]|Heterozygous||G|T|183|40.0|Non-synonymous|Unprocessed|APF-G1
1864163|IGL00757|16|26963939|D->A||0.04|Benign|0.05|tolerated|MGI:2685452|Gm606|predicted gene 606 [Source:MGI Symbol;Acc:MGI:2685452]|Heterozygous||T|G|98|39.0|Non-synonymous|Unprocessed|APF-G1
1864164|IGL00757|1|60195143|I->N||0.82|Possibly damaging|0.01|deleterious|MGI:2444343|Nbeal1|neurobeachin like 1 [Source:MGI Symbol;Acc:MGI:2444343]|Heterozygous||T|A|87|40.0|Non-synonymous|Unprocessed|APF-G1
1864165|IGL00757|X|76267372|I->T||0.92|Possibly damaging|0.01|deleterious|MGI:3648293|Gm4937|predicted gene 4937 [Source:MGI Symbol;Acc:MGI:3648293]|Heterozygous||T|C|68|39.0|Non-synonymous|Unprocessed|APF-G1
1864166|IGL00757|1|179769131|P->S||1.0|Probably damaging|0.04|deleterious|MGI:1915033|Ahctf1|AT hook containing transcription factor 1 [Source:MGI Symbol;Acc:MGI:1915033]|Heterozygous|Homozygous null mice die between E3.5 and E5.5.  The inner cell mass cells exhibit impaired proliferation and apoptosis when grown in culture.|G|A|60|37.0|Non-synonymous|Unprocessed|APF-G1
1864167|IGL00757|4|47405581|S->T||0.99|Probably damaging|0.01|deleterious|MGI:98728|Tgfbr1|transforming growth factor, beta receptor I [Source:MGI Symbol;Acc:MGI:98728]|Heterozygous|Homozygotes for some targeted null mutations exhibit defects of the yolk sac and placenta, lack circulating erythrocytes, and die at midgestation. Mutant endothelial cells show enhanced proliferation, improper migration, and reduced fibronectin production.|T|A|45|37.0|Non-synonymous|Unprocessed|APF-G1
1864168|IGL00757|8|45320615|I->M||0.76|Possibly damaging|0.01|deleterious|MGI:2142763|Cyp4v3|cytochrome P450, family 4, subfamily v, polypeptide 3 [Source:MGI Symbol;Acc:MGI:2142763]|Heterozygous||T|C|44|37.0|Non-synonymous|Unprocessed|APF-G1
1864169|IGL00757|11|70135150|I->F||0.97|Probably damaging||deleterious|MGI:2385729|Mgl2|macrophage galactose N-acetyl-galactosamine specific lectin 2 [Source:MGI Symbol;Acc:MGI:2385729]|Heterozygous||A|T|42|38.5|Non-synonymous|Unprocessed|APF-G1
1864170|IGL00757|17|70846240|Y->H||0.16|Benign|0.02|deleterious|MGI:1194497|Tgif1|TGFB-induced factor homeobox 1 [Source:MGI Symbol;Acc:MGI:1194497]|Heterozygous|Homozygous null mice display normal growth, behavior and fertility.|A|G|40|37.5|Non-synonymous|Unprocessed|APF-G1
1864171|IGL00757|12|87369068|E->K||1.0|Probably damaging|0.01|deleterious|MGI:108074|Sptlc2|serine palmitoyltransferase, long chain base subunit 2 [Source:MGI Symbol;Acc:MGI:108074]|Heterozygous|Mice homozygous for a knock-out allele exhibit embryonic lethality.  Mice heterozygous for this allele exhibit abnormal liver and circulating shingolipid levels.|C|T|36|37.5|Non-synonymous|Unprocessed|APF-G1
1864172|IGL00757|12|103693462|I->T||1.0|Probably damaging|0.01|deleterious|MGI:1915598|Serpina1f|serine (or cysteine) peptidase inhibitor, clade A, member 1F [Source:MGI Symbol;Acc:MGI:1915598]|Heterozygous||A|G|35|35.0|Non-synonymous|Unprocessed|APF-G1
1864173|IGL00757|9|31318546|V->A||0.24|Benign|0.1|tolerated|MGI:2682952|Prdm10|PR domain containing 10 [Source:MGI Symbol;Acc:MGI:2682952]|Heterozygous||T|C|35|39.0|Non-synonymous|Unprocessed|APF-G1
1864174|IGL00757|7|28154445|C->W||1.0|Probably damaging||deleterious|MGI:2442118|9530053a07rik|RIKEN cDNA 9530053A07 gene [Source:MGI Symbol;Acc:MGI:2442118]|Heterozygous||T|G|32|34.5|Non-synonymous|Unprocessed|APF-G1
1864175|IGL00757|11|84519652|F->S||0.28|Benign|0.13|tolerated|MGI:99783|Lhx1|LIM homeobox protein 1 [Source:MGI Symbol;Acc:MGI:99783]|Heterozygous|Homozygotes for targeted null mutations are small, fail to develop head structures anterior to rhombomere 3 in the hindbrain, lack kidneys and gonads, and show aberrant trajectories of limb motor axons. Most mutants die around embryonic day 10.|A|G|28|35.0|Non-synonymous|Unprocessed|APF-G1
1864176|IGL00757|9|54622719|I->R||0.05|Benign|0.01|deleterious|MGI:2385656|Acsbg1|acyl-CoA synthetase bubblegum family member 1 [Source:MGI Symbol;Acc:MGI:2385656]|Heterozygous|Mice homozygous for a null mutation display abnormalities in gonadotropin induced changes in testosterone production, Leydig cell morphology and long chain and very long chain fatty acid levels.|A|C|28|37.5|Non-synonymous|Unprocessed|APF-G1
1864177|IGL00757|3|96871534|T->S|||Benign|0.86|tolerated|MGI:1914799|Gpr89|G protein-coupled receptor 89 [Source:MGI Symbol;Acc:MGI:1914799]|Heterozygous||T|A|22|36.5|Non-synonymous|Unprocessed|APF-G1
1864178|IGL00757|1|188972196|S->P||1.0|Probably damaging|0.12|tolerated|MGI:2444629|Kctd3|potassium channel tetramerisation domain containing 3 [Source:MGI Symbol;Acc:MGI:2444629]|Heterozygous||A|G|16|35.0|Non-synonymous|Unprocessed|APF-G1
1864179|IGL00757|1|128236439|I->R||1.0|Probably damaging||deleterious|MGI:2448514|R3hdm1|R3H domain 1 (binds single-stranded nucleic acids) [Source:MGI Symbol;Acc:MGI:2448514]|Heterozygous||T|G|13|38.0|Non-synonymous|Unprocessed|APF-G1
1864180|IGL00757|10|40581327|T->M||1.0|Probably damaging||deleterious|MGI:1918090|Slc22a16|solute carrier family 22 (organic cation transporter), member 16 [Source:MGI Symbol;Acc:MGI:1918090]|Heterozygous||C|T|13|39.0|Non-synonymous|Unprocessed|APF-G1
1864181|IGL00757|19|7614559|E->D||0.99|Probably damaging|0.12|tolerated|MGI:1913977|Hrasls5|HRAS-like suppressor family, member 5 [Source:MGI Symbol;Acc:MGI:1913977]|Heterozygous||G|T|12|36.0|Non-synonymous|Unprocessed|APF-G1
1864182|IGL00757|2|122070959|H->R|||Benign|0.39|tolerated|MGI:2444989|Spg11|spastic paraplegia 11 [Source:MGI Symbol;Acc:MGI:2444989]|Heterozygous||T|C|12|36.5|Non-synonymous|Unprocessed|APF-G1
1864183|IGL00757|17|31443172|E->G||0.21|Benign|0.06|tolerated|MGI:1277179|Pde9a|phosphodiesterase 9A [Source:MGI Symbol;Acc:MGI:1277179]|Heterozygous||A|G|11|35.0|Non-synonymous|Unprocessed|APF-G1
1864184|IGL00757|7|46290128|D->E||0.99|Probably damaging||deleterious|MGI:1202064|Otog|otogelin [Source:MGI Symbol;Acc:MGI:1202064]|Heterozygous|Homozygotes for a number of different spontaneous and targeted mutations exhibit vestibular dysfunction, including circling, head tilt, impaired balance, coordination, and placing response. Mutants have impaired hearing, decreased brain stem auditory evoked potential, and ear abnormalities.|T|A|10|35.5|Non-synonymous|Unprocessed|APF-G1
1864185|IGL00757|13|11618604|Disrupted splicing||||||MGI:99685|Ryr2|ryanodine receptor 2, cardiac [Source:MGI Symbol;Acc:MGI:99685]|Heterozygous|Mice homozygous for a null mutation display embryonic lethality during organogenesis and abnormal cardiomyocyte morphology. Mice homozygous for a phosphorylation defective allele display decreased susceptibility to myocardial infarction-induced heart failure.|T|A|13|36.0|Splice|Unprocessed|APF-G1
1864186|IGL00757|19|4289311|Disrupted splicing||||||MGI:87940|Adrbk1|adrenergic receptor kinase, beta 1 [Source:MGI Symbol;Acc:MGI:87940]|Heterozygous|Homozygous mutation of this gene results in embryonic lethality likely due to heart failure. Homozygous mutant embryos are pale in appearance and exhibit ventricular hypoplasia.|A|G|12|34.0|Splice|Unprocessed|APF-G1
1864187|IGL00757|1|67152380|Disrupted splicing||||||MGI:891996|Cps1|carbamoyl-phosphate synthetase 1 [Source:MGI Symbol;Acc:MGI:891996]|Heterozygous|Homozygous mutation of this gene results in death by 36 hours after birth and hyperammonemia.|T|A|10|39.5|Splice|Unprocessed|APF-G1
1864630|IGL00742|3|64491413|I->T||0.31|Benign|0.19|tolerated|MGI:3649074|Vmn2r5|vomeronasal 2, receptor 5 [Source:MGI Symbol;Acc:MGI:3649074]|Heterozygous||A|G|478|39.0|Non-synonymous|Unprocessed|APF-G1
1864631|IGL00742|5|87127814|G->S||1.0|Probably damaging|0.02|deleterious|MGI:98900|Ugt2b5|UDP glucuronosyltransferase 2 family, polypeptide B5 [Source:MGI Symbol;Acc:MGI:98900]|Heterozygous||C|T|399|37.0|Non-synonymous|Unprocessed|APF-G1
1864632|IGL00742|2|25588687|E->G||0.99|Probably damaging||deleterious|MGI:2442633|B230208h17rik|RIKEN cDNA B230208H17 gene [Source:MGI Symbol;Acc:MGI:2442633]|Heterozygous||T|C|288|37.0|Non-synonymous|Unprocessed|APF-G1
1864633|IGL00742|7|103561356|Y->F||1.0|Probably damaging||deleterious|MGI:3030449|Olfr615|olfactory receptor 615 [Source:MGI Symbol;Acc:MGI:3030449]|Heterozygous||A|T|159|39.0|Non-synonymous|Unprocessed|APF-G1
1864634|IGL00742|5|33661234|H->Q||0.95|Possibly damaging|1.0|tolerated|MGI:1341163|Tacc3|transforming, acidic coiled-coil containing protein 3 [Source:MGI Symbol;Acc:MGI:1341163]|Heterozygous||T|A|157|38.0|Non-synonymous|Unprocessed|APF-G1
1864635|IGL00742|X|7931329|D->G||0.02|Benign|0.15|tolerated|MGI:1333752|Hdac6|histone deacetylase 6 [Source:MGI Symbol;Acc:MGI:1333752]|Heterozygous|Although mice homozygous for a knock-out allele exhibit global tubulin hyperacetylation, they are viable and fertile and display only a moderately impaired immune response and a minor increase in cancellous bone mineral density.|T|C|141|35.0|Non-synonymous|Unprocessed|APF-G1
1864636|IGL00742|X|160488719|T->M||1.0|Probably damaging||deleterious|MGI:2446854|Gpr64|G protein-coupled receptor 64 [Source:MGI Symbol;Acc:MGI:2446854]|Heterozygous|Hemizygous null male mice display reduced fertility, oligozoospermia, teratozoospermia, asthenozoospermia, abnormal epididymis morphology, and abnormal fluid accumulation resulting in enlarged testes and dilated seminiferous tubules.|C|T|115|37.0|Non-synonymous|Unprocessed|APF-G1
1864637|IGL00742|3|54372894|N->K||0.22|Benign|0.63|tolerated|MGI:1926321|Postn|periostin, osteoblast specific factor [Source:MGI Symbol;Acc:MGI:1926321]|Heterozygous|Homozygous null mice display abnormalities of the enamel, periodontal ligament, ameloblasts, and incisors. For one allele changing the hardness of the food alters the severity of the abnormalities.|T|A|114|35.0|Non-synonymous|Unprocessed|APF-G1
1864638|IGL00742|6|60958120|H->L||1.0|Probably damaging|0.01|deleterious|MGI:1918195|Mmrn1|multimerin 1 [Source:MGI Symbol;Acc:MGI:1918195]|Heterozygous||A|T|105|37.0|Non-synonymous|Unprocessed|APF-G1
1864639|IGL00742|13|52838102|E->G||0.36|Benign|0.32|tolerated|MGI:1338011|Auh|AU RNA binding protein/enoyl-coenzyme A hydratase [Source:MGI Symbol;Acc:MGI:1338011]|Heterozygous||T|C|96|39.0|Non-synonymous|Unprocessed|APF-G1
1864640|IGL00742|3|123113876|P->Q||1.0|Probably damaging||deleterious|MGI:2153070|Synpo2|synaptopodin 2 [Source:MGI Symbol;Acc:MGI:2153070]|Heterozygous||G|T|96|35.0|Non-synonymous|Unprocessed|APF-G1
1864641|IGL00742|3|82363420|V->A||0.14|Benign|0.16|tolerated|MGI:2442208|Mtap9|microtubule-associated protein 9 [Source:MGI Symbol;Acc:MGI:2442208]|Heterozygous||T|C|89|35.0|Non-synonymous|Unprocessed|APF-G1
1864642|IGL00742|1|40480991|S->T|||Benign|1.0|tolerated|MGI:105383|Il18r1|interleukin 18 receptor 1 [Source:MGI Symbol;Acc:MGI:105383]|Heterozygous|Mice homozygous for disruptions in this gene exhibit impaire Th1 cell development and defective NK cell physiology.|T|A|80|35.0|Non-synonymous|Unprocessed|APF-G1
1864643|IGL00742|6|88376279|L->Q||0.88|Possibly damaging|0.23|tolerated|MGI:2137092|Eefsec|eukaryotic elongation factor, selenocysteine-tRNA-specific [Source:MGI Symbol;Acc:MGI:2137092]|Heterozygous||A|T|73|38.0|Non-synonymous|Unprocessed|APF-G1
1864644|IGL00742|7|68190023|C->S|||Benign|0.72|tolerated|MGI:96433|Igf1r|insulin-like growth factor I receptor [Source:MGI Symbol;Acc:MGI:96433]|Heterozygous|Targeted null mutants die at birth of respiratory failure; fetuses exhibit retarded growth, organ hypoplasia, ossification delay and nervous system and epidermal abnormalities. hyft homozygous fetuses are growth retarded and exhibit hydrops fetalis and focal hepatic ischemia.|T|A|71|35.0|Non-synonymous|Unprocessed|APF-G1
1864645|IGL00742|1|56831541|N->K||0.11|Benign|0.02|deleterious|MGI:2679336|Satb2|special AT-rich sequence binding protein 2 [Source:MGI Symbol;Acc:MGI:2679336]|Heterozygous||A|T|70|35.5|Non-synonymous|Unprocessed|APF-G1
1864646|IGL00742|7|19914859|P->S||1.0|Probably damaging|0.01|deleterious|MGI:97822|Pvr|poliovirus receptor [Source:MGI Symbol;Acc:MGI:107741]|Heterozygous|Mice homozygous for one null allele have a reduced antibody response to oral immunization.  Mice homozygous for a